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1. The Italian SurveY on carDiac rEhabilitation - 2008 (ISYDE-2008): a snapshot of current cardiac rehabilitation programmes and provides in Italy Part 2: ISYDE-2008 investigators and directory of italian cardiac rehabilitation centers

Author

Tramarin R., De Feo S., Ambrosetti M., Griffo R., Maslowsky F., Vaghi P., Riccio C., Carlon R., Castello A., Ferratini M., Schweiger C., Chieffo C., Diaco T., Ciglia C., Lapolla A., Pietropaolo F., Furgi G., Martin G., Semprini P., Avallone A., Bertoli D., Belardinelli R., Soffiantino F., Scrutinio D., Maxia P., Coco R., Giustarini C., Anniboletti P., Favretto G., Calisi P., Chiavetta C., Guarracini L., Marcellini G., Iannopollo M., Borrello G., Matta M., Peccerillo N., Boncompagni F., Amici A., Feraco E., Pulitano G., Tripodi E., Capomolla S., Golino P., Parrilli G., Di Patria A., Di Gioia C., Miceli D., Perrotta S., Rubino A., Aulitto V., Riccio G., Codec L., Coruzzi P., Violi E., Nardini M., Urbinati S., Dcruz S., Piepoli M., Fucili A., Cerulli M., Roberto B., Balestra G., Tuniz D., Gori P., Marini R., Morgera T., Di Mario F., Volterrani M., Galati A., Salustri A., Jesi A.P., Lacch A., Loperfido F., Corsiglia L., Pantaleo P., Gigli G., Marchesi D., Febo O., Cobelli F., Malinverni C., Jones N., Anzà C., Frizzelli R., Gei P., Acquistapace F., Carugo S., Malfatto G., Meloni C., Giordano A., Schizzarotto A., Zanettini R., Bosco R., Aglieri S., Caprioli G., Cuocina N., Salvetti S., Savonelli C., Corda G., Meinecke C., Castiglioni, Pierfranco R., Giani P., Robustelli F., Gullace G., Passoni F., Barelli M.V., Richichi I., Rossi A., Politi, Persico M., Alessandrini F., Giannuzzi P., Mazzucco G., Bosimini E., Riva G., Massobrio N., Gondoni L., Aina F., Ingignoli B., Cal M.V., Carpagnano A., Costante A., Villella M., La Rosa C., Sannia L., Barbanto P., Rametta R., Albanese D., Circo A., Raciti R., Scarnato L., Dispensa F., La Spina L., Stuto A., Vasco C., Gibiino S., Gabriele M., Dispensieri C., Carini V., Provvidenza M., Scalzini A., Macchi C., Vannucci M., Iacopetti L., Cordoni M., Gabriele F., Pitscheider W., Bettini R., Girardini D., Mandorla S., Anniboletti F., Patriarchi F., Baroni P.L., Bordin F., Biondi P., Bellotto F., Zanocco A., Ponchia A., Mantovani E., Li Greci E., Celegon L., Baracchi S., Pizzolato G., Peroni L., Apolloni E., Guarniero M., Roncon L., VIGORITO, CARLO, Tramarin, R., De Feo, S., Ambrosetti, M., Griffo, R., Maslowsky, F., Vaghi, P., Riccio, C., Carlon, R., Castello, A., Ferratini, M., Schweiger, C., Chieffo, C., Vigorito, Carlo, Diaco, T., Ciglia, C., Lapolla, A., Pietropaolo, F., Furgi, G., Martin, G., Semprini, P., Avallone, A., Bertoli, D., Belardinelli, R., Soffiantino, F., Scrutinio, D., Maxia, P., Coco, R., Giustarini, C., Anniboletti, P., Favretto, G., Calisi, P., Chiavetta, C., Guarracini, L., Marcellini, G., Iannopollo, M., Borrello, G., Matta, M., Peccerillo, N., Boncompagni, F., Amici, A., Feraco, E., Pulitano, G., Tripodi, E., Capomolla, S., Golino, P., Parrilli, G., Di Patria, A., Di Gioia, C., Miceli, D., Perrotta, S., Rubino, A., Aulitto, V., Riccio, G., Codec, L., Coruzzi, P., Violi, E., Nardini, M., Urbinati, S., Dcruz, S., Piepoli, M., Fucili, A., Cerulli, M., Roberto, B., Balestra, G., Tuniz, D., Gori, P., Marini, R., Morgera, T., Di Mario, F., Volterrani, M., Galati, A., Salustri, A., Jesi, A. P., Lacch, A., Loperfido, F., Corsiglia, L., Pantaleo, P., Gigli, G., Marchesi, D., Febo, O., Cobelli, F., Malinverni, C., Jones, N., Anzà, C., Frizzelli, R., Gei, P., Acquistapace, F., Carugo, S., Malfatto, G., Meloni, C., Giordano, A., Schizzarotto, A., Zanettini, R., Bosco, R., Aglieri, S., Caprioli, G., Cuocina, N., Salvetti, S., Savonelli, C., Corda, G., Meinecke, C., Castiglioni, Pierfranco, R., Giani, P., Robustelli, F., Gullace, G., Passoni, F., Barelli, M. V., Richichi, I., Rossi, A., Politi, Persico, M., Alessandrini, F., Giannuzzi, P., Mazzucco, G., Bosimini, E., Riva, G., Massobrio, N., Gondoni, L., Aina, F., Ingignoli, B., Cal, M. V., Carpagnano, A., Costante, A., Villella, M., La Rosa, C., Sannia, L., Barbanto, P., Rametta, R., Albanese, D., Circo, A., Raciti, R., Scarnato, L., Dispensa, F., La Spina, L., Stuto, A., Vasco, C., Gibiino, S., Gabriele, M., Dispensieri, C., Carini, V., Provvidenza, M., Scalzini, A., Macchi, C., Vannucci, M., Iacopetti, L., Cordoni, M., Gabriele, F., Pitscheider, W., Bettini, R., Girardini, D., Mandorla, S., Anniboletti, F., Patriarchi, F., Baroni, P. L., Bordin, F., Biondi, P., Bellotto, F., Zanocco, A., Ponchia, A., Mantovani, E., Li Greci, E., Celegon, L., Baracchi, S., Pizzolato, G., Peroni, L., Apolloni, E., Guarniero, M., and Roncon, L.

Subjects
Pulmonary and Respiratory Medicine, Studio ISYDE, medicine.medical_specialty, Time Factors, Cardiologia Riabilitativa, medicine.medical_treatment, lcsh:Medicine, Directory, Rehabilitation Centers, Risk profile, medicine, Directories as Topic, Internet, Cardiac Rehabilitation, Rehabilitation, business.industry, Core component, Prevenzione Secondaria, lcsh:R, Health Surveys, Government Programs, Italy, Cardiovascular Diseases, Physical therapy, Snapshot (computer storage), Cardiology and Cardiovascular Medicine, business
Abstract

From January 28th to February 10th, 2008 the Italian Society of Cardiac Rehabilitation and Prevention (GICR) conducted a national web-based survey aimed to provide specific and updated information on organization and core components of cardiac rehabilitation (CR) in Italy, and to describe, both in residential and out-patient settings, indications for CR, clinical characteristics of referred patients, risk profile, performed diagnostic procedures, exercise and educational programme, treatments and arrangements for the follow-up [1, 2]. The ISYDE-2008 is a multicenter, longitudinal, prospective observation study whose design was previously described [1, 2].

Published
2016

2. Quality of work experience after angioplasty or heart surgery: a monocentric cohort study

Author

Miglioretti, M, Gragnano, A, Baiardo, G, Savioli, G, Corsiglia, L, Griffo, R, Miglioretti, M, Gragnano, A, Baiardo, G, Savioli, G, Corsiglia, L, and Griffo, R

Abstract

Purpose: The study evaluated work experience changes and its determinants after return to work (RTW) in angioplasty or heart surgery patients. Methods: During a 1-year period (2014) in a Rehabilitation Hospital in northwestern Italy, we approached 253 patients (19.3% of inpatients). 199 patients consented to complete a survey on job characteristics, job satisfaction, job involvement, illness perception, depression, anxiety, adherence to therapy, and sociodemographic characteristics. The data were analysed with paired sample t tests and random intercept regression models. Results: 156 patients completed both the baseline and the 6-month follow-up assessments. After 6 months, 137 (88%) patients return to work (86% male, M age = 51.9 ± 8.1). The patients predominantly underwent angioplasty/bypass (46%) or valve replacement/repair (38%). Work hours (WO), job satisfaction (JS), and job involvement (JI) significantly decreased after RTW (WO: t(132)= 2.07, p < 0.05; JS: t(134)= 2.56, p < 0.05; JI: t(129)= 4.14, p < 0.001). The decrease in work hours over time was associated with a within-subjects decrease in psychological job demands (Î2 = 5.107, t(112.1) = 2.21, p < 0.05) and job satisfaction (Î2 = 2.498, t(112.92)= 2.265, p < 0.05) and an increase in physical job demands (Î2 = − 1.314, t(112.07)= − 2.416, p < 0.05). The decrease in job satisfaction over time was related to a within-subjects decrease in decision latitude (Î2 = 0.505, t(116.43)= 2.825, p < 0.01) and an increase in psychological job demand (Î2 = − 0.586, t(116.78)= − 3.141, p < 0.01). The decrease in job involvement over time was associated with a decrease in physical job demands (Î2 = 0.063, t(117.19) = 2.157, p < 0.05) within-subjects. Conclusions: The study showed that many patients who RTW after angioplasty or heart surgery have poorer work experiences relative to changes in psychological and physical demands and more passive roles.

Published
2018

3. Qualità del rientro lavorativo in pazienti cardiovascolari: uno studio longitudinale

Author

Gragnano, A, Baiardo, G, Savioli, G, Conti, M, Corsiglia, L, GRAGNANO, ANDREA, Corsiglia, L., Gragnano, A, Baiardo, G, Savioli, G, Conti, M, Corsiglia, L, GRAGNANO, ANDREA, and Corsiglia, L.

Abstract

Diversi studi hanno analizzato i fattori clinici e psicosociali che influenzano il rientro lavorativo dopo un evento cardiovascolare[1]. Diversamente poca attenzione è stata posta alla qualità del rientro e su quei fattori psicosociali che possono differenziare un reintegro lavorativo pieno e attivo da un reinserimento formale e passivo [2]. Lo studio indaga questi aspetti attraverso una ricerca longitudinale condotta presso l’Istituto Cardiovascolare di Camogli. 74 pazienti sono stati valutati in tre momenti: all’inizio del percorso riabilitativo (t0) alle dimissioni dall’istituto (t1) sei mesi dopo (t2), quando il paziente aveva ripreso l’attività lavorativa. Le analisi effettuate mostrano un sostanziale peggioramento delle condizioni lavorative percepite e di benessere. Nonostante tra t0 e t2 vi sia una diminuzione delle ore lavorative e del carico di lavoro percepito, la Discrezionalità Decisionale e il Supporto Sociale percepiti sul posto di lavoro subiscono un calo significativo, così come il Job Involvement. Il percorso riabilitativo (t0 – t1) determina un generale miglioramento, con una flessione degli indici di Depressione, Ansia e Percezione d’intrusività della malattia. Il trend cambia al t2, dopo il rientro lavorativo (t1 – t2) con un forte incremento degli indici di Depressione e Ansia e un calo della Self-Efficacy sia di adesione alla terapia che di gestione dello stress. I risultati mostrano una sostanziale efficacia del percorso riabilitativo mentre rilevano una condizione di forte disagio psicosociale che il paziente affronta tra le dimissioni dall’istituto riabilitativo e il rientro lavorativo.

Published
2013

4. Qualità del rientro lavorativo in pazienti cardiovascolari: uno studio longitudinale

Author

GRAGNANO, ANDREA, Baiardo, G, Savioli, G, Conti, M, Corsiglia, L., Gragnano, A, Baiardo, G, Savioli, G, Conti, M, and Corsiglia, L

Subjects
return to work, quality of work, cardiovascular diseases, M-PSI/06 - PSICOLOGIA DEL LAVORO E DELLE ORGANIZZAZIONI
Abstract

Diversi studi hanno analizzato i fattori clinici e psicosociali che influenzano il rientro lavorativo dopo un evento cardiovascolare[1]. Diversamente poca attenzione è stata posta alla qualità del rientro e su quei fattori psicosociali che possono differenziare un reintegro lavorativo pieno e attivo da un reinserimento formale e passivo [2]. Lo studio indaga questi aspetti attraverso una ricerca longitudinale condotta presso l’Istituto Cardiovascolare di Camogli. 74 pazienti sono stati valutati in tre momenti: all’inizio del percorso riabilitativo (t0) alle dimissioni dall’istituto (t1) sei mesi dopo (t2), quando il paziente aveva ripreso l’attività lavorativa. Le analisi effettuate mostrano un sostanziale peggioramento delle condizioni lavorative percepite e di benessere. Nonostante tra t0 e t2 vi sia una diminuzione delle ore lavorative e del carico di lavoro percepito, la Discrezionalità Decisionale e il Supporto Sociale percepiti sul posto di lavoro subiscono un calo significativo, così come il Job Involvement. Il percorso riabilitativo (t0 – t1) determina un generale miglioramento, con una flessione degli indici di Depressione, Ansia e Percezione d’intrusività della malattia. Il trend cambia al t2, dopo il rientro lavorativo (t1 – t2) con un forte incremento degli indici di Depressione e Ansia e un calo della Self-Efficacy sia di adesione alla terapia che di gestione dello stress. I risultati mostrano una sostanziale efficacia del percorso riabilitativo mentre rilevano una condizione di forte disagio psicosociale che il paziente affronta tra le dimissioni dall’istituto riabilitativo e il rientro lavorativo.

Published
2013

6. Cardiac rehabilitation in very old patients: data from the Italian Survey onCardiac Rehabilitation-2008 (ISYDE-2008)--official report of the ItalianAssociation for Cardiovascular Prevention, Rehabilitation, and Epidemiology

Author

GIALLAURIA, FRANCESCO, VIGORITO, CARLO, Tramarin R, Fattirolli F, Ambrosetti M, De Feo S, Griffo R, Riccio C, Piepoli M, Guarracini L, Ciglia C, Marcellini G, Iannopollo M, Borrello G, Matta M, Peccerillo N, Boncompagni F, Amici A, Pietropaolo F, Feraco E, Pulitano G, Tripodi E, Furgi G, Chieffo C, Capomolla S, Golino P, Parrilli G, Di Patria A, Di Gioia C, Micieli D, Vigorito C, Perrotta S, Rubino A, Aulitto V, Riccio G, Codec L, Coruzzi P, Violi E, Nardini M, Urbinati S, Dcruz S, Semprini P, Fucili A, Cerulli M, Roberto B, Balestra G, Tuniz D, Martin G, Gori P, Marini R, Morgera T, Di Mario F, Volterrani M, Galati A, Salustri A, Jesi AP, Lacch A, Loperfido F, Corsiglia L, Pantaleo P, Gigli G, Bertoli D, Marchesi D, Febo O, Cobelli F, Malinverni C, Ferratini M, Jones N, Anzà C, Frizzelli R, Gei P, Acquistapace F, Pedretti R, Carugo S, Malfatto G, Diaco T, Meloni C, Giordano A, Schizzarotto A, Zanettini R, Bosco R, Aglieri S, Caprioli G, Cuocina N, Lazzaroni L, Lorenzi A, Savonelli C, Veniani M, Corda G, Meinecke C, Castiglioni G, Pierfranco R, Giani P, Robustelli della Cuna F, Gullace G, Passoni F, Barelli MV, Richichi I, Rossi A, Politi A, Belardinelli R, Persico M, Giannuzzi P, Mazzucco G, Bosimini E, Riva G, Soffiantino F, Massobrio N, Gondoni L, Aina F, Ingignoli B, Cal MV, Costante A, Scrutinio D, Villella M, La Rosa C, Sannia L, Barbanto P, Castello A, Coco R, Rametta R, Albanese D, Circo A, Raciti R, Scarnato L, Dispensa F, La Spina L, Stuto A, Vasco C, Gibiino S, Gabriele M, Dispensieri C, Carini V, Provvidenza M, Scalzini A, Giustarini C, Macchi C, Vannucci M, Iacopetti L, Cordoni M, Gabriele F, Santoni R, Pitscheider W, Bettini R, Girardini D, Mandorla S, Anniboletti F, Patriarchi F, Favretto G, Baroni PL, Bordin F, Biondi P, Bellotto F, Zanocco A, Ponchia A, Mantovani E, Li Greci E, Carlon R, Celegon L, Baracchi S, Pizzolato G, Peroni L, Apolloni E, Mosele G, Guarnerio M., Giallauria, Francesco, Vigorito, Carlo, Tramarin, R, Fattirolli, F, Ambrosetti, M, De Feo, S, Griffo, R, Riccio, C, Piepoli, M, Guarracini, L, Ciglia, C, Marcellini, G, Iannopollo, M, Borrello, G, Matta, M, Peccerillo, N, Boncompagni, F, Amici, A, Pietropaolo, F, Feraco, E, Pulitano, G, Tripodi, E, Furgi, G, Chieffo, C, Capomolla, S, Golino, P, Parrilli, G, Di Patria, A, Di Gioia, C, Micieli, D, Vigorito, C, Perrotta, S, Rubino, A, Aulitto, V, Riccio, G, Codec, L, Coruzzi, P, Violi, E, Nardini, M, Urbinati, S, Dcruz, S, Semprini, P, Fucili, A, Cerulli, M, Roberto, B, Balestra, G, Tuniz, D, Martin, G, Gori, P, Marini, R, Morgera, T, Di Mario, F, Volterrani, M, Galati, A, Salustri, A, Jesi, Ap, Lacch, A, Loperfido, F, Corsiglia, L, Pantaleo, P, Gigli, G, Bertoli, D, Marchesi, D, Febo, O, Cobelli, F, Malinverni, C, Ferratini, M, Jones, N, Anzà, C, Frizzelli, R, Gei, P, Acquistapace, F, Pedretti, R, Carugo, S, Malfatto, G, Diaco, T, Meloni, C, Giordano, A, Schizzarotto, A, Zanettini, R, Bosco, R, Aglieri, S, Caprioli, G, Cuocina, N, Lazzaroni, L, Lorenzi, A, Savonelli, C, Veniani, M, Corda, G, Meinecke, C, Castiglioni, G, Pierfranco, R, Giani, P, Robustelli della Cuna, F, Gullace, G, Passoni, F, Barelli, Mv, Richichi, I, Rossi, A, Politi, A, Belardinelli, R, Persico, M, Giannuzzi, P, Mazzucco, G, Bosimini, E, Riva, G, Soffiantino, F, Massobrio, N, Gondoni, L, Aina, F, Ingignoli, B, Cal, Mv, Costante, A, Scrutinio, D, Villella, M, La Rosa, C, Sannia, L, Barbanto, P, Castello, A, Coco, R, Rametta, R, Albanese, D, Circo, A, Raciti, R, Scarnato, L, Dispensa, F, La Spina, L, Stuto, A, Vasco, C, Gibiino, S, Gabriele, M, Dispensieri, C, Carini, V, Provvidenza, M, Scalzini, A, Giustarini, C, Macchi, C, Vannucci, M, Iacopetti, L, Cordoni, M, Gabriele, F, Santoni, R, Pitscheider, W, Bettini, R, Girardini, D, Mandorla, S, Anniboletti, F, Patriarchi, F, Favretto, G, Baroni, Pl, Bordin, F, Biondi, P, Bellotto, F, Zanocco, A, Ponchia, A, Mantovani, E, Li Greci, E, Carlon, R, Celegon, L, Baracchi, S, Pizzolato, G, Peroni, L, Apolloni, E, Mosele, G, and Guarnerio, M.

Subjects
cardiac rehabilitation, trial, ISYDE
Abstract

BACKGROUND: Using data from the Italian SurveY on carDiac rEhabilitation-2008 (ISYDE-2008), this study provides insight into the level of implementation of cardiac rehabilitation (CR) in very old cardiac patients. METHODS: Data from 165 CR units were collected online from January 28 to February 10, 2008. RESULTS: The study cohort consisted of 2,281 patients (66.9 ± 11.8 years): 1,714 (62.4 ± 9.6 years, 78% male) aged

Published
2010

8. The Italian SurveY on carDiac rEhabilitation 2008 (ISYDE 2008): study presentation

Author

Tramarin R., Ambrosetti M., De Feo S., Griffo R., Maslowsky F., Diaco T., Riccio C., Carlon R., Castello A., Ferratini M., Schweiger C., Chieffo C., Ciglia C., Lapolla A., Pietropaolo F., Furgi G., Martin G., Semprini P., Avallone A., Bertoli D., Belardinelli R., Soffiantino F., Scrutinio D., Maxia P., Coco R., Giustarini C., Anniboletti P., Favretto G., Vaghi P., Calisi P., Chiavetta C., Guarracini L., Marcellini G., Iannopollo M., Borello G., Matta M., Peccerillo N., Boncompagni . F, Amici A., Feraco E., Pulitanò G., Tripodi E., Capomolla S., Golino P., Parrilli G., Di Patria A., Di Gioia C., Micieli D., Perrotta S., Rubino A., Aulitto V., Riccio G., Codec L., Coruzzi P., Violi E., Nardini M., Urbinati S., Dcruz S., Piepoli M., Fucili A., Cerulli M., Roberto B., Balestra G., Tuniz D., Gori P., Marini R., Morgera T., Di Mario F., Volterrani M., Galati A., Salustri A., Jesi A.P., Lacch A., Loperfido F., Corsiglia L., Pantaleo P., Gigli G., Marchesi D., Febo O., Cobelli F., Malinverni C., Jones N., Anzà C., Frizelli R., Gei P., Acquistapace F., Pedretti R., Carugo S., Malfatto G., Meloni C., Giordano A., Schizzarotto A., Zanettini R., Bosco R., Occhi G., Aglieri S., Caprioli G., Cuocina N., Lazzaroni L., Laurenzi A., Savonelli C., Veniani M., Corda G., Meinecke C., Castiglioni G., Ravizza P., Giani P., Robustelli F., Gullace G., Passoni F., Barelli M.V., Richichi I., Rossi A., Politi A., Persico M., Giannuzzi P., Mazzucco G., Bosimini E., Riva G., Massobrio N., Gondoni L., Aina F., Ingignoli B., Cal M.V., Costante A., Villella M., La Rosa C., Sannia L., Barbanto P., Rametta R., Albanese D., Circo A., Raciti R., Scarnato L., Dispensa F., La Spina L., Stuto A., Vasco C., Gibiino S., Gabriele M., Dispensieri C., Carini V., Provvidenza M., Scalzini A., Macchi C., Fattirolli F., Vannucci M., Iacopetti L., Cordoni M., Gabriele F., Santoni R., Pitscheider W., Bettini R., Mandorla S., Anniboletti F., Patriarchi F., Baroni P.L., Bordin F., Biondi P., Bellotto F., Zanocco A., Ponchia A., Mantovani E., Li Greci E., Celegon L., Baracchi S., Pizzolato G., Peroni L., Apolloni E., Mosele G., Guarniero M., Roncon L., VIGORITO, CARLO, Tramarin, R., Ambrosetti, M., De Feo, S., Griffo, R., Maslowsky, F., Diaco, T., Riccio, C., Carlon, R., Castello, A., Ferratini, M., Schweiger, C., Chieffo, C., Vigorito, Carlo, Ciglia, C., Lapolla, A., Pietropaolo, F., Furgi, G., Martin, G., Semprini, P., Avallone, A., Bertoli, D., Belardinelli, R., Soffiantino, F., Scrutinio, D., Maxia, P., Coco, R., Giustarini, C., Anniboletti, P., Favretto, G., Vaghi, P., Calisi, P., Chiavetta, C., Guarracini, L., Marcellini, G., Iannopollo, M., Borello, G., Matta, M., Peccerillo, N., Boncompagni., F, Amici, A., Feraco, E., Pulitanò, G., Tripodi, E., Capomolla, S., Golino, P., Parrilli, G., Di Patria, A., Di Gioia, C., Micieli, D., Perrotta, S., Rubino, A., Aulitto, V., Riccio, G., Codec, L., Coruzzi, P., Violi, E., Nardini, M., Urbinati, S., Dcruz, S., Piepoli, M., Fucili, A., Cerulli, M., Roberto, B., Balestra, G., Tuniz, D., Gori, P., Marini, R., Morgera, T., Di Mario, F., Volterrani, M., Galati, A., Salustri, A., Jesi, A. P., Lacch, A., Loperfido, F., Corsiglia, L., Pantaleo, P., Gigli, G., Marchesi, D., Febo, O., Cobelli, F., Malinverni, C., Jones, N., Anzà, C., Frizelli, R., Gei, P., Acquistapace, F., Pedretti, R., Carugo, S., Malfatto, G., Meloni, C., Giordano, A., Schizzarotto, A., Zanettini, R., Bosco, R., Occhi, G., Aglieri, S., Caprioli, G., Cuocina, N., Lazzaroni, L., Laurenzi, A., Savonelli, C., Veniani, M., Corda, G., Meinecke, C., Castiglioni, G., Ravizza, P., Giani, P., Robustelli, F., Gullace, G., Passoni, F., Barelli, M. V., Richichi, I., Rossi, A., Politi, A., Persico, M., Giannuzzi, P., Mazzucco, G., Bosimini, E., Riva, G., Massobrio, N., Gondoni, L., Aina, F., Ingignoli, B., Cal, M. V., Costante, A., Villella, M., La Rosa, C., Sannia, L., Barbanto, P., Rametta, R., Albanese, D., Circo, A., Raciti, R., Scarnato, L., Dispensa, F., La Spina, L., Stuto, A., Vasco, C., Gibiino, S., Gabriele, M., Dispensieri, C., Carini, V., Provvidenza, M., Scalzini, A., Macchi, C., Fattirolli, F., Vannucci, M., Iacopetti, L., Cordoni, M., Gabriele, F., Santoni, R., Pitscheider, W., Bettini, R., Mandorla, S., Anniboletti, F., Patriarchi, F., Baroni, P. L., Bordin, F., Biondi, P., Bellotto, F., Zanocco, A., Ponchia, A., Mantovani, E., Li Greci, E., Celegon, L., Baracchi, S., Pizzolato, G., Peroni, L., Apolloni, E., Mosele, G., Guarniero, M., and Roncon, L.

Subjects
Heart Failure, Male, Internet, Time Factors, Heart Diseases, Cardiologia Riabilitativa, Data Collection, Myocardial Infarction, Rehabilitation Centers, Factor IX, Prevenzione secondaria, Italy, Risk Factors, Health Care Surveys, Practice Guidelines as Topic, Humans, Female, Longitudinal Studies, Public Health, ISYDE 2008, Coronary Artery Bypass, Follow-Up Studies
Abstract

In this paper, the Italian Society of Cardiac Rehabilitation and Prevention (GICR) presents the third survey on the status of cardiac rehabilitation (CR) in Italy. The Italian SurveY on carDiac rEhabilitation 2008 (ISYDE 2008) is a multicenter, observational study aimed at identifying the number and characteristics of Italian CR facilities, both in terms of health operators and interventions. Clinical records of all patients consecutively discharged within the whole network--composed of up to 200 CR units--from January 28 to February 10, 2008 will also be reviewed for diagnosis of admission, comorbidities, rehabilitation programs, and drug therapy, in order to obtain a snapshot of current implementation strategies in daily clinical practice. The survey will adopt a web-based methodology for data provision and transmission. Preliminary results of the survey are expected in the late summer 2008.

Published
2008

11. ICAROS (Italian survey on CardiAc RehabilitatiOn and Secondary prevention after cardiac revascularization): Temporary report of the first prospective, longitudinal registry of the cardiac rehabilitation network GICR/IACPR

Author

Griffo, Raffaele, Temporelli, Pier Luigi, Fattirolli, Francesco, Ambrosetti, M., Tramarin, Roberto, Vestri, Anna Rita, De Feo, Stefania, Tavazzi, Luigi, Giannuzzi, P., Tavazzi, L., Riccio, C., Ferratini, M., Belardinelli, R., Favretto, G., Scrutinio, D., Castello, A., Urbinati, Stefano, Piepoli, M., Carlon, R., Schweiger, C., Volterrani, Michele, Vigorito, C., Chieffo, C., Majani, G., Ciglia, C., Mantini, L., Borrello, G., Mazza, M. L., Scaglione, A., Furgi, G., Nicolino, A., Golino, P., Parrilli, G., Giallauria, F., Coruzzi, P., Gualerzi, M., D'Cruz, S., Violi, Daniele, Fattirolli, F., Burgisser, C., Giustarini, C., Macchi, C., Zipoli, R., Provvidenza, M., Scalzini, A., Ferrario, G., Eleas, Amado, Sarno, Claudia, Anniboletti, F., Filippucci, L., Mandorla, S., Baroni, P. L., Bellotto, F., Setzu, T., Bordin, F., Mantovani, Eugenia, Mosele, G. M., Semprini, P., Di Mario, F., Galati, A., Rossetti, A., Salustri, A., Cerquetani, E., Tassoni, G., Corsiglia, L., Acquistapace, F., Reggiani, R., Passera, M., Anzà, C., Baravelli, M., Cobelli, F., Diaco, T., Febo, O., Riccardi, Gabriele, Frizzelli, R., Gei, P., Proto, A., Giordano, A., Zanelli, E., Jones, N., Malfatto, G., Malinverni, C., Rocca, P., Pedretti, R., Vanitetti, R., Palvarini, M., Tramarin, R., Schizzarotto, A., Abello, P., Calisi, P., Pianese, M., Bosimini, E., Tidu, M., Temporelli, P. L., Mazzucco, G., Delpero, P., Soffiantino, F., Ingignoli, B., Polimeni, Gilda, Sannia, L., and Sarullo, F.

Subjects
Cardiac rehabilitation, Lifestyle intervention, Revascularization, Treatment adherence, Pulmonary and Respiratory Medicine
Published
2012

14. Gruppo chiuso o gruppo aperto semistrutturato? Confronto tra due modalità di gestione del gruppo educativo in cardiologia riabilitativa

Author

Baiardo, G, Savioli, G, Conti, M, Corsiglia, L, Miglioretti, M, MIGLIORETTI, MASSIMO, Baiardo, G, Savioli, G, Conti, M, Corsiglia, L, Miglioretti, M, and MIGLIORETTI, MASSIMO

Abstract

The objectives of this research are to present two different educational interventions in CR and to assess their effectiveness in improving the psychological state of patients. In Cardiovascular Institute of Camogli 153 patients were enrolled: 113 participated in a closed structured group intervention (control group) consisting of three meetings with a fixed number of patients in which the fundamental themes of CR were treated. The other 40 patients participated in the open semi-structured group (experimental group) develop to better meet the needs of patients in CR: providing a minimum of three meetings for each patient. All patients were evaluated at entrance and discharge with a set of questionnaires related to different psychological characteristics. The results show that the two interventions lead to positive outcomes, which are substantially overlappable in the short term. If these findings were confirmed on a larger group, this could give important organizational alternatives to the operator, without reducing the effectiveness of intervention.

Published
2011

25. ICAROS (Italian survey on CardiAc RehabilitatiOn and Secondary prevention after cardiac revascularization): Temporary report of the first prospective, longitudinal registry of the cardiac rehabilitation network GICR/IACPR,ICAROS (Italian survey on CardiAc RehabilitatiOn and Secondary prevention after cardiac revascularization): Primo bilancio di una grande esperienza scientifica del network riabilitativo GICR/IACPR

Author

Griffo, R., Temporelli, P. L., Fattirolli, F., Ambrosetti, M., Tramarin, R., Vestri, A. R., Feo, S., Tavazzi, L., Giannuzzi, P., Riccio, C., Ferratini, M., Belardinelli, R., Favretto, G., Scrutinio, D., Castello, A., Urbinati, S., Piepoli, M., Carlon, R., Schweiger, C., Volterrani, M., Vigorito, C., Chieffo, C., Majani, G., Ciglia, C., Mantini, L., Borrello, G., Mazza, M. L., Scaglione, A., Furgi, G., Nicolino, A., Golino, P., Parrilli, G., Giallauria, F., Coruzzi, P., Gualerzi, M., D Cruz, S., Violi, D., Burgisser, C., Giustarini, C., Macchi, C., Zipoli, R., Provvidenza, M., Scalzini, A., Ferrario, G., Eleas, A., Sarno, C., Anniboletti, F., Filippucci, L., Mandorla, S., Baroni, P. L., Bellotto, F., Setzu, T., Bordin, F., Mantovani, E., Mosele, G. M., Semprini, P., Di Mario, F., Galati, A., Rossetti, A., Salustri, A., Cerquetani, E., Tassoni, G., Corsiglia, L., Acquistapace, F., Reggiani, R., Passera, M., Anzà, C., Baravelli, M., Cobelli, F., Diaco, T., Febo, O., Riccardi, G., Frizzelli, R., Gei, P., Proto, A., Giordano, A., Zanelli, E., Jones, N., Malfatto, G., Malinverni, C., Rocca, P., Roberto Pedretti, Vanitetti, R., Palvarini, M., Schizzarotto, A., Abello, P., Calisi, P., Pianese, M., Bosimini, E., Tidu, M., Mazzucco, G., Delpero, P., Soffiantino, F., Ingignoli, B., Polimeni, G., Sannia, L., and Sarullo, F.

26. The Italian SurveY on carDiac rEhabilitation 2008 (ISYDE 2008): Study presentation,Il progetto ISYDE 2008 (Italian SurveY on carDiac rEhabilitation): Strutture, rete, organizzazione e programmi di cardiologia riabilitativa in Italia

Author

Tramarin, R., Ambrosetti, M., Feo, S., Griffo, R., Maslowsky, F., Diaco, T., Riccio, C., Carlon, R., Castello, A., Ferratini, M., Schweiger, C., Chieffo, C., Vigorito, C., Piepoli, M., Ciglia, C., Lapolla, A., Pietropaolo, F., Furgi, G., Martin, G., Semprini, P., Avallone, A., Bertoli, D., Belardinelli, R., Soffiantino, F., Scrutinio, D., Maxia, P., Coco, R., Giustarini, C., Anniboletti, P., Favretto, G., Vaghi, P., Calisi, P., Chiavetta, C., Guarracini, L., Marcellini, G., Iannopollo, M., Borrello, G., Matta, M., Peccerillo, N., Boncompagni, F., Amici, A., Feraco, E., Pulitanò, G., Tripodi, E., Capomolla, S., Golino, P., Parrilli, G., Di Patria, A., Di Gioia, C., Micieli, D., Perrotta, S., Rubino, A., Aulitto, V., Riccio, G., Codec, L., Coruzzi, P., Violi, E., Nardini, M., Urbinati, S., Dcruz, S., Fucili, A., Cerulli, M., Roberto, B., Balestra, G., Tuniz, D., Gori, P., Marini, R., Morgera, T., Di Mario, F., Volterrani, M., Galati, A., Salustri, A., Jesi, A. P., Lacch, A., Loperfido, F., Corsiglia, L., Pantaleo, P., Gigli, G., Marchesi, D., Febo, O., Cobelli, F., Malinverni, C., Jones, N., Anzà, C., Frizzelli, R., Gei, P., Acquistapace, F., Pedretti, R., STEFANO CARUGO, Malfatto, G., Meloni, C., Giordano, A., Schizzarotto, A., Zanettini, R., Bosco, R., Occhi, G., Aglieri, S., Caprioli, G., Cuocina, N., Lazzaroni, L., Lorenzi, A., Savonelli, C., Veniani, M., Corda, G., Meinecke, C., Castiglioni, G., Ravizza, P., Giani, P., Robustelli, F., Gullace, G., Passoni, F., Barelli, M. V., Richichi, I., Rossi, A., Politi, A., Persico, M., Giannuzzi, P., Mazzucco, G., Bosimini, E., Riva, G., Massobrio, N., Gondoni, L., Aina, F., Ingignoli, B., Cal, M. V., Costante, A., Villella, M., La Rosa, C., Sannia, L., Barbanto, P., Rametta, R., Albanese, D., Circo, A., Raciti, R., Scarnato, L., Dispensa, F., La Spina, L., Stuto, A., Vasco, C., Gibiino, S., Gabriele, M., Dispensieri, C., Carini, V., Provvidenza, M., Scalzini, A., Macchi, C., Fattirolli, F., Vannucci, M., Iacopetti, L., Cordoni, M., Gabriele, F., Santoni, R., Pitscheider, W., Bettini, R., Girardini, D., Mandorla, S., Anniboletti, F., Patriarchi, F., Baroni, P. L., Bordin, F., Biondi, P., Bellotto, F., Zanocco, A., Ponchia, A., Mantovani, E., Li Greci, E., Celegon, L., Baracchi, S., Pizzolato, G., Peroni, L., Apolloni, E., Mosele, G., Guarniero, M., and Roncon, L.

29. Adaptation and validation of the cardiovascular version of the Return-to-Work Obstacles and Self-Efficacy Scale (ROSES-CVD) to the Italian context

Author

Andrea Gragnano, Marc Corbière, Eleonora Picco, Alessia Negrini, Gaia Savioli, Massimo Conti, Luca Corsiglia, Massimo Miglioretti, Gragnano, A, Corbière, M, Picco, E, Negrini, A, Savioli, G, Conti, M, Corsiglia, L, and Miglioretti, M

Subjects
Return to work, cardiovascular disease, questionnaire, Rehabilitation, cardiovascular rehabilitation, psychosocial factor, self-efficacy
Abstract

Purpose: Effective cardiac rehabilitation interventions must provide adequate support to overcome psychosocial return-to-work (RTW) barriers. No validated instrument is available for this aim for cardiovascular patients. The Return-to-work Obstacles and Self-Efficacy Scale (ROSES) measures RTW obstacles workers perceive and the self-efficacy for overcoming them through 46 items and ten dimensions. This study aimed to adapt and validate ROSES for cardiovascular disease (CVD) in the Italian context. Methods: This prospective study involved 183 CVD working patients at baseline and 121 six months later. ROSES-CVD internal consistency, construct, and predictive validity was evaluated with Cronbach’s α, Confirmatory factor analyses (CFA), and ANCOVAs. Results: CFAs adequately replicated the original ROSES model (CFI =.92–.96; TLI =.91–.94; RMSEA =.042–.057; SRMR =.046–.071) with α close or higher than.70 for all dimensions. Four ROSES-CVD dimensions significantly predicted the number of days to RTW controlling for age, gender, educational level, and surgery type. Workers who perceived salient RTW obstacles and low self-efficacy in any of these dimensions in mean returned to work from 38 to 53 days later. Conclusions: The study supported the validity and reliability of ROSES-CVD. This tool can be used in rehabilitation to detect CVD patients at risk of a longer RTW process and define appropriate cardiac rehabilitation intervention.IMPLICATIONS FOR REHABILITATION Vocational rehabilitation interventions should provide tailor-made support to overcome RTW barriers based on individual risk assessment The Italian translation of ROSES-CVD is a valid and reliable tool to measure psychosocial barriers to RTW among CVD working patients The use of ROSES-CVD would allow detection of CVD patients at risk of longer RTW process Administering ROSES-CVD can help focus traditional vocational intervention on individually relevant obstacles to RTW.

Published
2022

30. Quality of work experience after angioplasty or heart surgery: a monocentric cohort study

Author

Gaia Savioli, Massimo Miglioretti, Andrea Gragnano, Giacomo Baiardo, Luca Corsiglia, Raffaele Griffo, Miglioretti, M, Gragnano, A, Baiardo, G, Savioli, G, Corsiglia, L, and Griffo, R

Subjects
Adult, Male, Rehabilitation hospital, medicine.medical_specialty, Job involvement, Return to work, medicine.medical_treatment, Workload, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Angioplasty, medicine, Humans, Prospective Studies, Cardiac Surgical Procedures, Depression (differential diagnoses), Quality of work life, Rehabilitation, business.industry, Public Health, Environmental and Occupational Health, Middle Aged, Cardiovascular disease, 030210 environmental & occupational health, Surgery, Italy, Job satisfaction, Anxiety, Female, medicine.symptom, business, Cohort study
Abstract

The study evaluated work experience changes and its determinants after return to work (RTW) in angioplasty or heart surgery patients. During a 1-year period (2014) in a Rehabilitation Hospital in northwestern Italy, we approached 253 patients (19.3% of inpatients). 199 patients consented to complete a survey on job characteristics, job satisfaction, job involvement, illness perception, depression, anxiety, adherence to therapy, and sociodemographic characteristics. The data were analysed with paired sample t tests and random intercept regression models. 156 patients completed both the baseline and the 6-month follow-up assessments. After 6 months, 137 (88%) patients return to work (86% male, M age = 51.9 ± 8.1). The patients predominantly underwent angioplasty/bypass (46%) or valve replacement/repair (38%). Work hours (WO), job satisfaction (JS), and job involvement (JI) significantly decreased after RTW (WO: t (132) = 2.07, p

Published
2017

31. Gruppo chiuso o gruppo aperto semistrutturato? Confronto tra due modalità di gestione del gruppo educativo in cardiologia riabilitativa

Author

Massimo Miglioretti, Gaia Savioli, Luca Corsiglia, Giacomo Baiardo, Massimo Conti, Baiardo, G, Savioli, G, Conti, M, Corsiglia, L, and Miglioretti, M

Subjects
gruppo chiuso, Health (social science), gruppo aperto, M-PSI/06 - PSICOLOGIA DEL LAVORO E DELLE ORGANIZZAZIONI, self-efficacy, Applied Psychology, rappresentazione di malattia
Abstract

Obiettivi di questa ricerca sono presentare due diverse modalitŕ di intervento educativo in cardiologia riabilitativa (CR) e valutarne l'efficacia in termini di miglioramento dello stato psicologico dei pazienti. Presso l'Istituto Cardiovascolare di Camogli sono stati reclutati 153 pazienti: 113 hanno partecipato ad un intervento di gruppo chiuso strutturato (gruppo di controllo) costituito da tre incontri con numero fisso di pazienti in cui si trattavano tematiche fondamentali in CR; gli altri 40 pazienti hanno partecipato al gruppo aperto semistrutturato (gruppo sperimentale) nato per meglio venire incontro alle esigenze dei pazienti ricoverati, che ha previsto almeno tre incontri per ciascun paziente. Tutti i pazienti sono stati valutati, all'ingresso e alle dimissioni, con una batteria di questionari indaganti diverse caratteristiche psicologiche. I risultati mostrano come le due modalitŕ portino a esiti positivi sostanzialmente sovrapponibili nel breve termine. Se tali riscontri fossero confermati su gruppi piů ampi, si potrebbero configurare per l'operatore importanti alternative organizzative, senza che l'intervento ne risenta in efficacia.

Published
2011

34. Adaptation and validation of the cardiovascular version of the Return-to-Work Obstacles and Self-Efficacy Scale (ROSES-CVD) to the Italian context.

Author

Gragnano A, Corbière M, Picco E, Negrini A, Savioli G, Conti M, Corsiglia L, and Miglioretti M

Subjects
Humans, Prospective Studies, Self Efficacy, Reproducibility of Results, Return to Work psychology, Cardiovascular Diseases
Abstract

Purpose: Effective cardiac rehabilitation interventions must provide adequate support to overcome psychosocial return-to-work (RTW) barriers. No validated instrument is available for this aim for cardiovascular patients. The Return-to-work Obstacles and Self-Efficacy Scale (ROSES) measures RTW obstacles workers perceive and the self-efficacy for overcoming them through 46 items and ten dimensions. This study aimed to adapt and validate ROSES for cardiovascular disease (CVD) in the Italian context., Methods: This prospective study involved 183 CVD working patients at baseline and 121 six months later. ROSES-CVD internal consistency, construct, and predictive validity was evaluated with Cronbach's α, Confirmatory factor analyses (CFA), and ANCOVAs., Results: CFAs adequately replicated the original ROSES model (CFI = .92-.96; TLI = .91-.94; RMSEA = .042-.057; SRMR = .046-.071) with α close or higher than .70 for all dimensions. Four ROSES-CVD dimensions significantly predicted the number of days to RTW controlling for age, gender, educational level, and surgery type. Workers who perceived salient RTW obstacles and low self-efficacy in any of these dimensions in mean returned to work from 38 to 53 days later., Conclusions: The study supported the validity and reliability of ROSES-CVD. This tool can be used in rehabilitation to detect CVD patients at risk of a longer RTW process and define appropriate cardiac rehabilitation intervention.IMPLICATIONS FOR REHABILITATIONVocational rehabilitation interventions should provide tailor-made support to overcome RTW barriers based on individual risk assessmentThe Italian translation of ROSES-CVD is a valid and reliable tool to measure psychosocial barriers to RTW among CVD working patientsThe use of ROSES-CVD would allow detection of CVD patients at risk of longer RTW processAdministering ROSES-CVD can help focus traditional vocational intervention on individually relevant obstacles to RTW.

Published
2023
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35. Quality of work experience after angioplasty or heart surgery: a monocentric cohort study.

Author

Miglioretti M, Gragnano A, Baiardo G, Savioli G, Corsiglia L, and Griffo R

Subjects
Adult, Angioplasty rehabilitation, Cardiac Surgical Procedures rehabilitation, Cohort Studies, Female, Humans, Italy, Job Satisfaction, Male, Middle Aged, Prospective Studies, Return to Work psychology, Surveys and Questionnaires, Workload, Angioplasty psychology, Cardiac Surgical Procedures psychology, Return to Work statistics & numerical data
Abstract

Purpose: The study evaluated work experience changes and its determinants after return to work (RTW) in angioplasty or heart surgery patients., Methods: During a 1-year period (2014) in a Rehabilitation Hospital in northwestern Italy, we approached 253 patients (19.3% of inpatients). 199 patients consented to complete a survey on job characteristics, job satisfaction, job involvement, illness perception, depression, anxiety, adherence to therapy, and sociodemographic characteristics. The data were analysed with paired sample t tests and random intercept regression models., Results: 156 patients completed both the baseline and the 6-month follow-up assessments. After 6 months, 137 (88%) patients return to work (86% male, M age = 51.9 ± 8.1). The patients predominantly underwent angioplasty/bypass (46%) or valve replacement/repair (38%). Work hours (WO), job satisfaction (JS), and job involvement (JI) significantly decreased after RTW (WO: t (132)  = 2.07, p < 0.05; JS: t (134)  = 2.56, p < 0.05; JI: t (129)  = 4.14, p < 0.001). The decrease in work hours over time was associated with a within-subjects decrease in psychological job demands (β = 5.107, t (112.1 ) = 2.21, p < 0.05) and job satisfaction (β = 2.498, t (112.92)  = 2.265, p < 0.05) and an increase in physical job demands (β = - 1.314, t (112.07)  = - 2.416, p < 0.05). The decrease in job satisfaction over time was related to a within-subjects decrease in decision latitude (β = 0.505, t (116.43)  = 2.825, p < 0.01) and an increase in psychological job demand (β = - 0.586, t (116.78)  = - 3.141, p < 0.01). The decrease in job involvement over time was associated with a decrease in physical job demands (β = 0.063, t (117.19 ) = 2.157, p < 0.05) within-subjects., Conclusions: The study showed that many patients who RTW after angioplasty or heart surgery have poorer work experiences relative to changes in psychological and physical demands and more passive roles.

Published
2018
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36. Soluble form of the endothelial adhesion molecule CD146 binds preferentially CD16+ monocytes.

Author

Garibaldi S, Barisione C, Ghigliotti G, Spallarossa P, Barsotti A, Fabbi P, Corsiglia L, Palmieri D, Palombo D, and Brunelli C

Subjects
Aged, Aged, 80 and over, CD146 Antigen blood, CD146 Antigen metabolism, Cell Adhesion, Cell Movement, Cells, Cultured, GPI-Linked Proteins metabolism, Humans, Inflammation metabolism, Lipopolysaccharide Receptors metabolism, Middle Aged, Protein Binding, Recombinant Proteins metabolism, Endothelial Cells metabolism, Monocytes metabolism, Receptors, IgG metabolism
Abstract

The cell adhesion molecule CD146 is normally located at the endothelial cell-to-cell junction and colocalizes with actin cytoskeleton. The soluble form of CD146 (sCD146) has been identified in the endothelial cell supernatant and in normal human plasma, and is increased in pathologic conditions with altered endothelial function. Soluble CD146 binding to monocytes promotes their transendothelial migration, which represents a central step in the development of atherosclerotic plaque. Since peripheral blood monocytes are characterized by a phenotypic and functional heterogeneity, with different transendothelial migration capacity, we hypothesized that monocyte subsets differently bind sCD146. Based on surface CD14 and CD16 expression monocytes were distinguished by flow cytometry (FACS) into three subsets: CD14++/CD16-, CD14++/CD16+ and CD14+/CD16+. CD16+ monocytes have been found to possess higher transendothelial migration ability. FACS analysis on blood monocytes from 30 healthy subjects revealed that higher percentages of CD14++/CD16+ (median, first and third quartile: 2.26, 1.62-3.87) and of CD14+/CD16+ (2.59, 1.28-4.80) were positive for CD146 (both p < 0.01), in comparison to CD14++/CD16- (0.66, 0.47-1.01). Moreover, in vitro treatment of ficoll separated monocytes with recombinant CD146 showed that both CD16+ subsets increased their percentage of CD146-positive events compared to CD16- monocytes (p < 0.01). Soluble CD146 levels were evaluated by ELISA in plasma samples of subjects from our study group and showed a correlation with percentage of CD146-positive CD14+/CD16+ monocyte subset. In this work we have demonstrated that monocyte subsets behave differently with regard to their sCD146 binding activity; because binding of CD146 influences transendothelial migration of monocytes, modulation of monocyte-CD146 interaction may represent a potential target to limit atherosclerotic plaque development.

Published
2012
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37. CD14CD16 monocyte subset levels in heart failure patients.

Author

Barisione C, Garibaldi S, Ghigliotti G, Fabbi P, Altieri P, Casale MC, Spallarossa P, Bertero G, Balbi M, Corsiglia L, and Brunelli C

Subjects
Aged, Biomarkers blood, C-Reactive Protein metabolism, Case-Control Studies, Cohort Studies, Disease Progression, GPI-Linked Proteins, Heart Failure physiopathology, Humans, Inflammation Mediators blood, Kidney physiopathology, Leukocyte Count, Male, Monocytes enzymology, Neutrophils, Peptidyl-Dipeptidase A blood, Heart Failure blood, Lipopolysaccharide Receptors blood, Monocytes classification, Monocytes immunology, Receptors, IgG blood
Abstract

Our aim was to define the distribution of monocyte subsets in a cohort of congestive heart failure (CHF) patients, to verify whether increased severity of CHF is linked to the expansion of specific monocyte subsets, and finally to investigate the relationship between monocyte subset relative frequencies, laboratory parameters of inflammation, and monocyte ACE expression. Thirty consecutive CHF patients and 26 healthy control subjects were evaluated for peripheral blood monocyte expression of CD14, CD16 and CD143 (ACE) by flow-cytometry, and for endothelial-derived soluble CD146 levels by ELISA. CD14++ CD16+ frequency was significantly higher in CHF patients than in Controls (%, median value and IQ) (12.3, 8.7-14.8 vs 5.9, 4.7-6.9, p< 0.05, CHF vs Controls), and it increased depending on how high NYHA class was, on worsening LV ejection fraction and on circulating pro-BNP values. Furthermore, it was associated with increasing creatinine and with decreasing GFR and albumin levels. Monocyte CD143 expression was significantly elevated in CHF patients as compared to Controls, and positively associated with CD14++ CD16+ levels. Frequencies of CD14+ CD16+ monocytes were significantly lower in CHF patients as compared to Controls, and negatively correlated with levels of soluble CD146 (r=-0.529; p 0.048). In conclusion, monocytic CD14++ CD16+ frequency and CD143 levels are increased and reflect disease status and progressive cardiac deterioration in CHF patients. The CD14+ CD16+ subset is depleted in CHF and is linked to endothelial damage in this group of patients. Although the question of whether differences in monocyte CD14CD16 expansion are causal or whether they represent a marker of HF progression which is potentially relevant for risk prediction remains unanswered, we believe that our data represent an important tool for exploring the role of selective inflammatory pathways in CHF progression.

Published
2010
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38. [Clinical and organizational evidence of the efficacy and effectiveness from cardiac rehabilitation: an update].

Author

Griffo R, Gigli G, Bertoli D, Corsiglia L, Emanuelli F, Colotto P, Andreoli G, and Flego G

Subjects
Cardiovascular Diseases economics, Cost-Benefit Analysis, Guidelines as Topic, Humans, Italy, Models, Organizational, Regional Health Planning, Cardiac Rehabilitation, Evidence-Based Medicine, Outcome Assessment, Health Care economics, Outcome Assessment, Health Care organization & administration, Program Evaluation
Abstract

The increasing evidence on the favourable cost/effectiveness impact of the comprehensive cardiac rehabilitation program for the treatment of a wide spectrum of cardiovascular conditions have imposed to healthcare services a major attention on a critical analysis of the results in different clinical indications and delivery organisations. The Regional Health Agency of Liguria, in the occasion of drawing up regional guidelines directed to define the clinical indications and the effectiveness of the cardiac rehabilitation delivery model (in-patients, out-patients and home-based) and its requisites, indications and procedures, has updated the reference guidelines (PLNG and SIGN) with the evidence provided by the more recent literature, focusing its attention on the clinical and, in particular, organizational effectiveness. The document, on the base of these evidences, provides some effective proposals and some organizational advices.

Published
2009
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39. Increased neutrophil lifespan in patients with congestive heart failure.

Author

Tracchi I, Ghigliotti G, Mura M, Garibaldi S, Spallarossa P, Barisione C, Boasi V, Brunelli M, Corsiglia L, Barsotti A, and Brunelli C

Subjects
Aged, C-Reactive Protein metabolism, Cells, Cultured, Disease Progression, Endothelium, Vascular pathology, Enzyme-Linked Immunosorbent Assay, Follow-Up Studies, Heart Failure blood, Heart Failure physiopathology, Humans, Leukocyte Count, Prognosis, Prospective Studies, Stroke Volume, Apoptosis physiology, Heart Failure pathology, Neutrophils pathology
Abstract

Aims: Congestive heart failure (CHF) can be thought of as a state of chronic immune activation. Polymorphonuclear neutrophil (PMN) apoptosis is one of the mechanisms responsible for the resolution of inflammation. A reduced PMN apoptotic rate in CHF patients may generate a persistent inflammatory response and hence mediate tissue damage in this group of patients. We aimed to measure levels of spontaneous apoptosis of circulating PMNs in CHF patients and in controls, and to examine whether NYHA class, left ventricular ejection fraction (LV-EF), and laboratory parameters of inflammation, endothelial damage, and of liver and renal function, could predict the rate of PMN apoptosis in CHF patients., Methods and Results: A total of 29 CHF patients and 26 controls were studied. Propidium iodide and flow cytometry were used to assess PMN apoptosis. Delay in PMN apoptosis was expressed as percentage (expressed as median, first and third quartiles) of surviving PMNs in the study subjects. We found an increased percentage of surviving PMNs [38(27.1-47.1)] in CHF patients compared with controls [19.4 (15.8-25.2)] (P < 0.05). The PMN survival rate in the CHF group was correlated to NYHA class, and plasma levels of C-reactive protein and alkaline phosphatase, while it was inversely correlated to LV-EF and protein levels. A positive relationship between PMN survival and increased ex vivo endothelial apoptosis was found., Conclusion: Increased PMN lifespan in patients with worsening CHF could be used as a novel measurement of tissue and endothelial damage in this group of patients.

Published
2009
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40. Perfusion-contraction mismatch during inotropic stimulation in hibernating myocardium.

Author

Sambuceti G, Giorgetti A, Corsiglia L, Marini C, Schneider-Eicke J, Brunelli C, Marzullo P, L'Abbate A, Capponnetto S, and Parodi O

Subjects
Coronary Angiography, Coronary Circulation drug effects, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Myocardial Stunning diagnostic imaging, Radiopharmaceuticals, Tomography, Emission-Computed, Cardiotonic Agents pharmacology, Dobutamine pharmacology, Echocardiography methods, Myocardial Contraction drug effects, Myocardial Stunning physiopathology
Abstract

Unlabelled: The aims of this study were to assess the value of dobutamine echocardiography in identifying myocardial hibernation versus stunning and to elucidate the underlying pathophysiological mechanism of the contractile impairment., Methods: Twenty-one patients with isolated stenosis of the left anterior descending artery were evaluated 1 mo after thrombolysed acute anterior infarction. Regional function and blood flow were measured using echocardiography and PET at rest and during dobutamine administration (10 microg/kg/min)., Results: Defined by [18F]fluorodeoxyglucose uptake, 36 of 102 dyssynergic segments were necrotic, and 66 were viable. The latter segments were subdivided according to their [13N]ammonia flow distribution: 30 hibernating regions with perfusion defects (flow of <80% of maximum) and 36 stunned areas with preserved resting perfusion (flow of > or =80% of maximum). Resting flows were similar in necrosis and hibernation (0.43 +/- 0.18 versus 0.47 +/- 0.16 ml x min(-1) x g(-1); not significant), and both resting values were lower than those seen in stunning (0.79 +/- 0.24; p < 0.05). Flow response to dobutamine was markedly reduced in necrosis (dobutamine/resting flow = 1.16 +/- 0.27), whereas it was maintained in hibernation (1.65 +/- 0.54) and stunning (1.42 +/- 0.57). Dobutamine improved function in a higher number of stunned (55%) than hibernating (16%) or necrotic (11%) segments., Conclusion: Dobutamine improves function mainly in stunned myocardium and does not reliably identify hibernation. The lack of functional response in hibernation is not related to an exhausted vasodilating capacity.

Published
1998

41. Improvement of hibernation in the clinical setting.

Author

Brunelli C, Parodi O, Sambuceti G, Corsiglia L, Spallarossa P, Rosa GM, Giorgetti A, Bezante GP, Nista N, and Caponnetto S

Subjects
Hemodynamics, Humans, Myocardial Stunning drug therapy, Perfusion, Cardiotonic Agents pharmacology, Dobutamine pharmacology, Heart physiopathology, Myocardial Stunning physiopathology, Nisoldipine pharmacology, Vasodilator Agents pharmacology
Published
1996
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42. [Hypercholesterolemia and coronary disease: intervention strategies].

Author

Brunelli C, Spallarossa P, Saccani A, Corsiglia L, Ghigliotti G, and Caponnetto S

Subjects
Anticholesteremic Agents therapeutic use, Cholesterol blood, Coronary Disease etiology, Coronary Disease mortality, Humans, Hypercholesterolemia complications, Hypercholesterolemia mortality, Myocardial Ischemia drug therapy, Myocardial Ischemia etiology, Myocardial Ischemia mortality, Prognosis, Quality of Life, Remission Induction, Coronary Disease drug therapy, Hypercholesterolemia drug therapy
Abstract

The decision to treat hypercholesterolemia must take into account both the risk of death and myocardial infarction and the risk/benefit ratio of treatment. Nowadays there is convincing evidence that hypercholesterolemia in patients with previous myocardial infarction is an important prognostic factor: furthermore, the excess of risk due to cholesterol is consistently higher than that in the general population. Prospective studies demonstrated that cholesterol lowering treatment obtained either with diet or drugs can improve survival and quality of life in postinfarction patients. Experimental, clinical and angiographic studies suggested that cholesterol lowering therapy can produce both stabilization and regression of the atherosclerotic plaque. In view of this, the evaluation of cholesterol level must be part of the general work-up of patients with previous myocardial infarction. The satisfactory results obtained with diet suggest to try a dietary treatment in post-infarction patients with high cholesterol level before using drugs. Since there are no clear-cut upper values, the end point of treatment should be to lower cholesterol levels to the values recommended for the general population, although we believe that threshold values to be obtained in these subjects should be lower than those requested in primary prevention.

Published
1991

43. Should we treat silent myocardial ischaemia?

Author

Brunelli C, Spallarossa P, Corsiglia L, Iannetti M, and Caponnetto S

Subjects
Age Factors, Angina, Unstable diagnosis, Angina, Unstable therapy, Coronary Disease diagnosis, Coronary Disease epidemiology, Coronary Disease etiology, Electrocardiography, Exercise Test, Female, Follow-Up Studies, Humans, Male, Myocardial Infarction complications, Myocardial Infarction rehabilitation, Prognosis, Risk Factors, Sex Factors, Coronary Disease therapy
Abstract

Silent myocardial ischaemia has been documented in various clinical entities. Exercise testing and ambulatory ECG monitoring are the most widely used tests for documenting silent ischaemia, and both exercise-induced and daily life ischaemia have the potential to trigger prolonged functional and structural changes. Numerous clinical investigations in apparently healthy subjects, in stable and unstable angina, in patients with a previous myocardial infarction indicate that ischaemia has an adverse prognostic influence, independent of whether the ischaemia is silent or symptomatic. Methods for documenting silent ischaemia lead to different considerations according to each clinical syndrome of coronary artery disease. This review deals with the different intervention strategies derived from the unique prognostic profiles offered by silent ischaemia in a variety of clinical entities.

Published
1991

44. [Not Available].

Author

Corsiglia L

Subjects
History, Ancient, History, Early Modern 1451-1600, History, Medieval, History, Modern 1601-, India, Biochemistry history, Chemistry history
Published
1973

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