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1. Brief report: High incidence of peridiagnosis thromboembolic events in patients with BRAF-mutant lung cancer

Author

Aparicio, Inmaculada, Iranzo, Patricia, Reyes, Roxana, Bote, Helena, Saigi, María, Bringas, Marianela, Bosch-Barrera, Joaquim, Corral, Jesús, Aparisi, Francisco, Ruffinelli, Jose C., Jiménez, Beatriz, Lage, Yolanda, López-Castro, Rafael, Majem, Margarita, Vázquez, Sergio, Artal, Ángel, Rodríguez-Pérez, Ángel, Lázaro-Quintela, Martín, Torres, José Miguel Sánchez, Reguart, Noemí, Cucurull, Marc, Gil-Bazo, Ignacio, Camps, Carlos, Nadal, Ernest, del Barrio, Anabel, Garrido, Pilar, Dómine, Manuel, Álvarez, Rosa, Muñoz, Andrés J., and Calles, Antonio

Published
2023
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3. Updated Overall Survival in a Randomized Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations

Author

Mok, Tony S., Cheng, Ying, Zhou, Xiangdong, Lee, Ki Hyeong, Nakagawa, Kazuhiko, Niho, Seiji, Chawla, Alka, Rosell, Rafael, Corral, Jesus, Migliorino, Maria Rita, Pluzanski, Adam, Noonan, Kay, Tang, Yiyun, Pastel, Malaika, Wilner, Keith D., and Wu, Yi-Long

Published
2021
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4. Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

Author

de Bono, Johann, Lin, Chia-Chi, Chen, Li-Tzong, Corral, Jesus, Michalarea, Vasiliki, Rihawi, Karim, Ong, Michael, Lee, Jih-Hsiang, Hsu, Chih-Hung, Yang, James Chih-Hsin, Shiah, Her-Shyong, Yen, Chia-Jui, Anthoney, Alan, Jove, Maria, Buschke, Susanne, Fuertig, René, Schmid, Ulrike, Goeldner, Rainer-Georg, Strelkowa, Natalja, Huang, Dennis Chin-Lun, Bogenrieder, Thomas, Twelves, Chris, and Cheng, Ann-Lii

Published
2020
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5. Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial

Author

Michels, Sebastian, Massutí, Bartomeu, Schildhaus, Hans-Ulrich, Franklin, Jeremy, Sebastian, Martin, Felip, Enriqueta, Grohé, Christian, Rodriguez-Abreu, Delvys, Abdulla, Diana S.Y., Bischoff, Helge, Brandts, Christian, Carcereny, Enric, Corral, Jesús, Dingemans, Anne-Marie C., Pereira, Eva, Fassunke, Jana, Fischer, Rieke N., Gardizi, Masyar, Heukamp, Lukas, Insa, Amelia, Kron, Anna, Menon, Roopika, Persigehl, Thorsten, Reck, Martin, Riedel, Richard, Rothschild, Sacha I., Scheel, Andreas H., Scheffler, Matthias, Schmalz, Petra, Smit, Egbert F., Limburg, Meike, Provencio, Mariano, Karachaliou, Niki, Merkelbach-Bruse, Sabine, Hellmich, Martin, Nogova, Lucia, Büttner, Reinhard, Rosell, Rafael, and Wolf, Jürgen

Published
2019
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8. Career opportunities and benefits for young oncologists in the European Society for Medical Oncology (ESMO)

Author

Morgan, Gilberto, Lambertini, Matteo, Kourie, Hampig Raphael, Amaral, Teresa, Argiles, Guillem, Banerjee, Susana, Cardone, Claudia, Corral, Jesus, De Mattos-Arruda, Letticia, öztürk, Akif, Petrova, Mila, Poulsen, Laurids, Strijbos, Michiel, Tyulyandina, Alexandra, Vidra, Radu, Califano, Raffaele, de Azambuja, Evandro, Garrido Lopez, Pilar, Guarneri, Valentina, Reck, Martin, Moiseyenko, Vladimir, Martinelli, Erika, Douillard, Jean-Yves, Stahel, Rolf, Voest, Emile, Arnold, Dirk, Cardoso, Fatima, Casali, Paolo, Cervantes, Andrés, Eggermont, Alexander M.M., Eniu, Alexandru, Jassem, Jacek, Pentheroudakis, George, Peters, Solange, McGregor, Keith, Rauh, Stefan, Zielinski, Christoph C., Ciardiello, Fortunato, Tabernero, Josep, and Preusser, Matthias

Published
2016
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9. Description of the Factors Associated with Trigger Finger in Patients Treated at Petroleos Mexicanos “Pemex”

Author

Barbosa-Villarreal, Fernando, primary, Márquez-Espriella, Cuahutémoc, additional, Dávila-Díaz, Rodrigo, additional, Cuervo-Vergara, Marco A., additional, Arambula-Sánchez, Blanca Y., additional, Cahuana-Quispe, Alberto I., additional, Esquivel-Chávez, Victor A., additional, García-Córdova, Carlos E., additional, Campollo-López, Ana P., additional, Gutierrez-Alvarez, Mauricio, additional, García-Corral, Jesus R., additional, Chama-Naranjo, Alfredo, additional, de Luna-Gallardo, Daniel, additional, Pulido-López, Ricardo A., additional, Recio-España, Isaac F., additional, Campos-Serna, Esteban I., additional, Navarro-Delgadillo, Carlos I., additional, Martínez-López, José C., additional, Avalos-Gómez, Victor H., additional, and Cruz-Zarate, Alejandro, additional

Published
2023
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12. Long-Term and Low-Grade Safety Results of a Phase III Study (PARAMOUNT): Maintenance Pemetrexed Plus Best Supportive Care Versus Placebo Plus Best Supportive Care Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung Cancer

Author

Pujol, Jean-Louis, Paz-Ares, Luis, de Marinis, Filippo, Dediu, Mircea, Thomas, Michael, Bidoli, Paolo, Corral, Jesus, San Antonio, Belen, Chouaki, Nadia, John, William, Zimmermann, Annamaria, Visseren-Grul, Carla, and Gridelli, Cesare

Published
2014
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15. Maintenance therapy with pemetrexed plus best supportive care versus placebo plus best supportive care after induction therapy with pemetrexed plus cisplatin for advanced non-squamous non-small-cell lung cancer (PARAMOUNT): a double-blind, phase 3, randomised controlled trial

Author

Paz-Ares, Luis, de Marinis, Filippo, Dediu, Mircea, Thomas, Michael, Pujol, Jean-Louis, Bidoli, Paolo, Molinier, Olivier, Sahoo, Tarini Prasad, Laack, Eckart, Reck, Martin, Corral, Jesús, Melemed, Symantha, John, William, Chouaki, Nadia, Zimmermann, Annamaria H, Visseren-Grul, Carla, and Gridelli, Cesare

Published
2012
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16. rmd202h.pdf

Author

Garcia-Corral, Jesus Ricardo

Abstract

BACKGROUND: Pemphigus vulgaris is a bullous autoimmune disease due to the production of IgG type autoantibodies against desmogleins 1 and 3. Mucosal affec tion is the initial presentation in over the half of the patients, with subsequent skin dissemination. CLINICAL CASES: This paper reports the case of a 39 year-old man, who initially showed a localized skin disease in the nasal ala and a superficial case in an adolescent of 16 years old, with exulcerations and crusts in the face, trunk and extremities. Histo pathology examination and direct immunofluorescence assay confirmed diagnosis of pemphigus vulgaris and in the second case histopathology showed a subcorneal form. Patient with pemphigus vulgaris was treated with high-potency topical steroids with resolution of lesions and superficial case showed a very mild response to the treatment with systemic corticosteroids. CONCLUSIONS: Treatment is based on the administration of oral glucocorticoids. The evolution of the disease is chronic. The prognosis of foliar pemphigus is usually considered favorable, due to the good response to treatment.

Published
2022
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19. Updated Overall Survival in a Randomized Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations

Author

Mok, Tony S., primary, Cheng, Ying, additional, Zhou, Xiangdong, additional, Lee, Ki Hyeong, additional, Nakagawa, Kazuhiko, additional, Niho, Seiji, additional, Chawla, Alka, additional, Rosell, Rafael, additional, Corral, Jesus, additional, Migliorino, Maria Rita, additional, Pluzanski, Adam, additional, Noonan, Kay, additional, Tang, Yiyun, additional, Pastel, Malaika, additional, Wilner, Keith D., additional, and Wu, Yi-Long, additional

Published
2020
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20. Safety, Resource Use, and Quality of Life in Paramount: A Phase III Study of Maintenance Pemetrexed Versus Placebo after Induction Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung Cancer

Author

Gridelli, Cesare, de Marinis, Filippo, Pujol, Jean-Louis, Reck, Martin, Ramlau, Rodryg, Parente, Barbara, Pieters, Thierry, Middleton, Gary, Corral, Jesus, Winfree, Katherine, Melemed, Symantha, Zimmermann, Anna, John, William, Beyrer, Julie, Chouaki, Nadia, Visseren-Grul, Carla, and Paz-Ares, Luis G.

Published
2012
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23. Change in grass population in an open grassland under continuous grazing in Northern Mexico/Cambio en la poblacion de gramineas en un pastizal abierto bajo sistema de pastoreo continuo en el Norte de Mexico/Alterar na populacao de gramineas em um pasto aberto baixo sistema de pastoreio continuo no Norte do Mexico

Author

Corral, Jesus Herrera, Arrieta, Yolanda Herrera, Carreon, Francisco O. Carrete, Abarca, Norma Almaraz, Jimenez, Nestor Naranjo, and Gonzalez, Francisco J. Gonzalez

Published
2011

25. Características epidemiológicas de las nuevas infecciones causadas por el VIH comparadas con los casos de sida. La epidemia de VIH/sida en el País Vasco

Author

Javier Rodríguez, Francisco, Zulaika, Daniel, Agirrebengoa, Koldo, Andía, Ander, Arrizabalaga, Julio, María Bustillo, José, Mar Cámara, Mari, Corral, Jesús, Carmen Orive, Mari, Goikoetxea, Julio, Antonio Iribarren, José, López de Munain, Josefina, Manuel Lorenzo, José, José Martín Gudino, María, Martínez, Eduardo, Mayo, José, Portu, Joseba, Silvariño, Rafael, and Zubero, Zuriña

Published
2004
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26. Management of common adverse events related to first-line dacomitinib use in EGFR mutation-positive non-small-cell lung cancer: a pooled safety analysis

Author

Zhou, Qing, primary, Wu, Yi-Long, additional, Corral, Jesus, additional, Nakagawa, Kazuhiko, additional, Garon, Edward B, additional, Sbar, Eric I, additional, Wang, Tao, additional, Sandin, Rickard, additional, Noonan, Kay, additional, Gernhardt, Diana, additional, and Mok, Tony S, additional

Published
2019
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27. Human immunodeficiency virus-induced immunosuppression: a risk factor for human papillomavirus infection

Author

Matorras, Roberto, Ariceta, Jose M., Rementeria, Angel, Corral, Jesus, Gutierrez de Teran, Gloria, Diez, Javier, Montoya, Francisco, and Rodriguez-Escudero, J.

Subjects
Papillomavirus infections -- Risk factors, Immunosuppression -- Health aspects, Papillomavirus infections -- Prognosis, HIV infection -- Complications, Papillomavirus infections -- Physiological aspects, Health
Abstract

Infection by human papillomavirus (HPV) is associated with venereal warts (genital condylomata); it is also associated with increased risk of cervical cancer in women. Since immunosuppression is thought to increase the risk of HPV infection, it is possible that women infected with the human immunodeficiency virus (HIV, which causes AIDS) have a higher risk of HPV infection. This was tested by comparing the proportion of HIV-infected women in two groups: 92 with genital condylomata due to HPV, and 100 randomly selected controls without condylomata due to HPV. Results showed that 15 of the 92 HPV-infected women (16.3 percent) tested positive for HIV infection, compared with no members of the control group. Thirteen of the 15 HIV-infected women were intravenous drug abusers. They were also younger and had delivered fewer children than control women or women with HPV but without HIV infection; comparisons of these latter two groups showed that condylomatous (HPV-infected), non-HIV-infected women were younger and had fewer deliveries than controls. Women infected with both viral agents had undergone more induced abortions, on average, than those infected with HPV only. Women with HPV, regardless of HIV status, had a higher rate of sexually transmitted diseases than controls. HPV-associated lesions were more persistent in HIV-infected than in non-HIV-infected patients. Although the greater proportion of HIV-positive women in the HPV-infected group suggests that the risk of HPV infection may be elevated in such a population, the other differences noted between the groups (age, parity) do not allow firm conclusions about immunosuppression and HPV to be drawn. It seems advisable to test patients who are intravenous drug users and who have HPV infections for HIV infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

29. Improvement in Overall Survival in a Randomized Study That Compared Dacomitinib With Gefitinib in Patients With Advanced Non–Small-Cell Lung Cancer and EGFR-Activating Mutations

Author

Mok, Tony S., primary, Cheng, Ying, additional, Zhou, Xiangdong, additional, Lee, Ki Hyeong, additional, Nakagawa, Kazuhiko, additional, Niho, Seiji, additional, Lee, Min, additional, Linke, Rolf, additional, Rosell, Rafael, additional, Corral, Jesus, additional, Migliorino, Maria Rita, additional, Pluzanski, Adam, additional, Sbar, Eric I., additional, Wang, Tao, additional, White, Jane Liang, additional, and Wu, Yi-Long, additional

Published
2018
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30. EUCROSS: A European Phase II Trial of Crizotinib in Advanced Adenocarcinoma of the Lung Harboring ROS1 Rearrangements - Preliminary Results

Author

Michels, Sebastian, Gardizi, Masyar, Schmalz, Petra, Thurat, Meike, Pereira, Eva, Sebastian, Martin, Carcereny, Enric, Corral, Jesus, Paz-Ares, Luis, Felip, Enriqueta, Grohe, Christian, Rodriguez Abreu, Delvys, Insa Molla, Amelia, Bischoff, Helge, Reck, Martin, Karachaliou, Niki, Scheel, Andreas, Brandes, Vanessa, Rieke, Fischer, Nogova, Lucia, Scheffler, Matthias, Franklin, Jeremy, Hellmich, Martin, Massuti, Bartomeu, Buettner, Reinhard, Rosell, Rafael, Wolf, Juergen, Michels, Sebastian, Gardizi, Masyar, Schmalz, Petra, Thurat, Meike, Pereira, Eva, Sebastian, Martin, Carcereny, Enric, Corral, Jesus, Paz-Ares, Luis, Felip, Enriqueta, Grohe, Christian, Rodriguez Abreu, Delvys, Insa Molla, Amelia, Bischoff, Helge, Reck, Martin, Karachaliou, Niki, Scheel, Andreas, Brandes, Vanessa, Rieke, Fischer, Nogova, Lucia, Scheffler, Matthias, Franklin, Jeremy, Hellmich, Martin, Massuti, Bartomeu, Buettner, Reinhard, Rosell, Rafael, and Wolf, Juergen

Published
2017

31. Assessment of the state of degradation of various types of steel bars used as reinforcement in concrete carbonated or contaminated by chlorides

Author

Rivera-Corral, Jesus Octavio, Laboratoire Matériaux et Durabilité des constructions (LMDC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Paul Sabatier - Toulouse III, Ginette Arliguié, Gerardo del Jesus Fajardo San Miguel, Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Corrosion, Reinforced concrete, Chlorides, Chlorures, Carbonation, Traitement de barres d'acier, Types steel bars, Carbonatation, Béton armé, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

Corrosion of reinforcing bars in concrete is considered as the most important problem that affects the integrity of the civil structures. In order to obtain a better resistance to corrosion, various superficial processes as coatings with zinc (AG) or such as the dual covering metallic-polymeric (AD) are applicate to ordinary steel bars (AC). On the other hand, steel bars with thermal treatments (ATT), principally developed as an alternative to improve the mechanical properties without the use of ferroalloys, are not used in concrete. The behavior of these kinds of bars in front of mechanisms of deterioration as the corrosion induced by chlorides or carbonation has not yet been studied. In this work, all these various steel bars (AG, AD, AC and ATT) were embedded in prismatic specimens of concrete made with two ratio water/cement: 0.45 and 0.65. Previously, steels bars were characterized by mechanical tests and metallographic identifications. Then, specimens were placed in several sites of exposition: urban/industrial environment, or coastal environment, or controlled atmosphere in laboratory. During these expositions, measurements of corrosion potential, linear polarization resistance, and electrochemical impedance spectroscopy were regularly carried out. For each type of steel bar, chloride threshold level and progress of the carbonation depth were determined. Furthermore, by means of the induction of a galvanic couple during design of new samples, the electrochemical behavior of the steels bars AC, ATT and AG was followed up experimentally and then analyzed with finite element model. It was founded that the different steels bars exposed in controlled atmosphere of laboratory followed a same sequence in depassivation for both ratios water/cement: ATT, AC, AG and AD. The chloride thresholds were higher for steels bars AG and AD. However, visual inspection showed that the morphology of damages caused on AG bars was most important compared with the other steel bars. In the propagation phase, the corrosion current density of the ATT bars was lower, even to that obtained by the AG bars.; Le béton armé est sans conteste le matériau le plus utilisé dans la construction, et permet de réaliser la plupart des infrastructures dans tous les pays du monde. Cependant, sa durabilité peut être compromise de façon prématurée par la corrosion des aciers, qui est la pathologie considérée comme la plus dangereuse vis-à-vis du maintien de l'intégrité des ouvrages de Génie Civil. Afin d'obtenir une meilleure résistance face au risque de corrosion, l'acier conventionnel (AC) peut être soumis à divers traitements, dont les plus connus sont le recouvrement superficiel par d'autres matériaux métalliques à base de zinc (AG), ou par des revêtements doubles métal-polymères (AD). Cependant, il existe aussi des barres d'acier thermiquement traitées (ATT) qui ne sont actuellement quasiment pas utilisées en tant qu'armatures. De ce fait, leur comportement face aux mécanismes de détérioration comme la corrosion en milieu cimentaire causée par les chlorures ou la carbonatation est encore très peu connu. Dans ce travail, le comportement des différentes barres d'acier mentionnées ci-dessus a été étudié. Des éprouvettes prismatiques de béton, incluant ces types d'armatures, ont été fabriquées avec deux rapports E/C : 0,45 et 0,65. Avant leur utilisation, les barres ont été caractérisées mécaniquement et métallographiquement. Ensuite, les éprouvettes ont été placées dans différentes conditions d'exposition : un environnement urbain/industriel ou côtier, et un environnement contrôlé en laboratoire. Des mesures du potentiel de corrosion, de résistance de polarisation linéaire, et de spectroscopie d'impédance électrochimique ont été mises en œuvre durant la période d'exposition. Pour chaque série, la teneur critique en chlorures a été déterminée, et la progression de la profondeur de carbonatation a été suivie. En outre, en induisant un couple galvanique par effet de la carbonatation, des mesures originales du comportement électrochimique de ces barres ont été effectuées puis une analyse, en s'appuyant sur une modélisation en éléments finis, en a été faite. Dans l'environnement contrôlé en laboratoire, l'ordre de dépassivation des différentes barres exposées a été observé de façon similaire pour les deux rapports E/C, à savoir : ATT, AC, AG et enfin AD. Une teneur critique en chlorures plus élevée a été obtenue pour les barres AG et AD. Cependant, lors de l'inspection visuelle, les dommages causés sur les armatures AG étaient plus élevés que sur les autres types de barres. Enfin, durant l'étape de propagation, la densité de courant de corrosion des barres ATT et des barres AG s'est révélée inférieure.

Published
2016

32. Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial

Author

Wu, Yi-Long, primary, Cheng, Ying, additional, Zhou, Xiangdong, additional, Lee, Ki Hyeong, additional, Nakagawa, Kazuhiko, additional, Niho, Seiji, additional, Tsuji, Fumito, additional, Linke, Rolf, additional, Rosell, Rafael, additional, Corral, Jesus, additional, Migliorino, Maria Rita, additional, Pluzanski, Adam, additional, Sbar, Eric I, additional, Wang, Tao, additional, White, Jane Liang, additional, Nadanaciva, Sashi, additional, Sandin, Rickard, additional, and Mok, Tony S, additional

Published
2017
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34. MA07.05 EUCROSS: A European Phase II Trial of Crizotinib in Advanced Adenocarcinoma of the Lung Harboring ROS1 Rearrangements - Preliminary Results

Author

Michels, Sebastian, primary, Gardizi, Masyar, additional, Schmalz, Petra, additional, Thurat, Meike, additional, Pereira, Eva, additional, Sebastian, Martin, additional, Carcereny, Enric, additional, Corral, Jesus, additional, Paz-Ares, Luis, additional, Felip, Enriqueta, additional, Grohé, Christian, additional, Abreu, Delvys Rodriguez, additional, Molla, Amelia Insa, additional, Bischoff, Helge, additional, Reck, Martin, additional, Karachaliou, Niki, additional, Scheel, Andreas, additional, Brandes, Vanessa, additional, Rieke, Fischer, additional, Nogova, Lucia, additional, Scheffler, Matthias, additional, Franklin, Jeremy, additional, Hellmich, Martin, additional, Massuti, Bartomeu, additional, Buettner, Reinhard, additional, Rosell, Rafael, additional, and Wolf, Jürgen, additional

Published
2017
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35. OA11.02 Randomized Phase 1b/3 Study of Erlotinib plus Ramucirumab in First-Line EGFR Mut + Stage IV NSCLC: Phase 1b Safety Results

Author

Nakagawa, Kazuhiko, primary, Paz-Ares, Luis, additional, Ponce, Santiago, additional, Corral, Jesus, additional, Vidal, Oscar, additional, Nadal, Ernest, additional, Kiura, Katsuyuki, additional, Liu, Jingyi, additional, He, Shuang, additional, Treat, Joseph, additional, Dalal, Rita, additional, Lee, Pablo, additional, and Reck, Martin, additional

Published
2017
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36. Management of common adverse events related to first-line dacomitinib use in mutation-positive non-small-cell lung cancer: a pooled safety analysis.

Author

Zhou, Qing, Wu, Yi-Long, Corral, Jesus, Nakagawa, Kazuhiko, Garon, Edward B, Sbar, Eric I, Wang, Tao, Sandin, Rickard, Noonan, Kay, Gernhardt, Diana, and Mok, Tony S

Abstract

Aim: This pooled safety analysis was conducted to analyze incidence and management of key dacomitinib-associated adverse drug reactions (ADRs). Patients & methods: Patients with EGFR mutation-positive advanced non-small-cell lung cancer who received first-line dacomitinib at the 45 mg/day recommended starting dose were included. ADRs were identified based on reasonable association with EGFR tyrosine kinase inhibitors. Results: Overall, 251/255 patients (98%) experienced ADRs. The most common were diarrhea, rash, stomatitis, nail disorder and dry skin. Dose interruptions and dose reductions were reported in 47 and 52% of patients, respectively. Fewer grade 3 key ADRs were observed following dose reductions. Conclusion: Dacomitinib was generally tolerable. Most reported ADRs were known to be associated with EGFR tyrosine kinase inhibitors and were managed with standard medical management and dose modifications. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Contribution à l'évaluation de l'état de dégradation de divers types de barres d'acier utilisées comme armatures dans des bétons carbonatés ou pollués par des chlorures

Author

Rivera-Corral, Jesus Octavio and Rivera-Corral, Jesus Octavio

Abstract

Le béton armé est sans conteste le matériau le plus utilisé dans la construction, et permet de réaliser la plupart des infrastructures dans tous les pays du monde. Cependant, sa durabilité peut être compromise de façon prématurée par la corrosion des aciers, qui est la pathologie considérée comme la plus dangereuse vis-à-vis du maintien de l'intégrité des ouvrages de Génie Civil. Afin d'obtenir une meilleure résistance face au risque de corrosion, l'acier conventionnel (AC) peut être soumis à divers traitements, dont les plus connus sont le recouvrement superficiel par d'autres matériaux métalliques à base de zinc (AG), ou par des revêtements doubles métal-polymères (AD). Cependant, il existe aussi des barres d'acier thermiquement traitées (ATT) qui ne sont actuellement quasiment pas utilisées en tant qu'armatures. De ce fait, leur comportement face aux mécanismes de détérioration comme la corrosion en milieu cimentaire causée par les chlorures ou la carbonatation est encore très peu connu. Dans ce travail, le comportement des différentes barres d'acier mentionnées ci-dessus a été étudié. Des éprouvettes prismatiques de béton, incluant ces types d'armatures, ont été fabriquées avec deux rapports E/C : 0,45 et 0,65. Avant leur utilisation, les barres ont été caractérisées mécaniquement et métallographiquement. Ensuite, les éprouvettes ont été placées dans différentes conditions d'exposition : un environnement urbain/industriel ou côtier, et un environnement contrôlé en laboratoire. Des mesures du potentiel de corrosion, de résistance de polarisation linéaire, et de spectroscopie d'impédance électrochimique ont été mises en œuvre durant la période d'exposition. Pour chaque série, la teneur critique en chlorures a été déterminée, et la progression de la profondeur de carbonatation a été suivie. En outre, en induisant un couple galvanique par effet de la carbonatation, des mesures originales du comportement électrochimique de ces barres ont été effectuées puis une analy, Corrosion of reinforcing bars in concrete is considered as the most important problem that affects the integrity of the civil structures. In order to obtain a better resistance to corrosion, various superficial processes as coatings with zinc (AG) or such as the dual covering metallic-polymeric (AD) are applicate to ordinary steel bars (AC). On the other hand, steel bars with thermal treatments (ATT), principally developed as an alternative to improve the mechanical properties without the use of ferroalloys, are not used in concrete. The behavior of these kinds of bars in front of mechanisms of deterioration as the corrosion induced by chlorides or carbonation has not yet been studied. In this work, all these various steel bars (AG, AD, AC and ATT) were embedded in prismatic specimens of concrete made with two ratio water/cement: 0.45 and 0.65. Previously, steels bars were characterized by mechanical tests and metallographic identifications. Then, specimens were placed in several sites of exposition: urban/industrial environment, or coastal environment, or controlled atmosphere in laboratory. During these expositions, measurements of corrosion potential, linear polarization resistance, and electrochemical impedance spectroscopy were regularly carried out. For each type of steel bar, chloride threshold level and progress of the carbonation depth were determined. Furthermore, by means of the induction of a galvanic couple during design of new samples, the electrochemical behavior of the steels bars AC, ATT and AG was followed up experimentally and then analyzed with finite element model. It was founded that the different steels bars exposed in controlled atmosphere of laboratory followed a same sequence in depassivation for both ratios water/cement: ATT, AC, AG and AD. The chloride thresholds were higher for steels bars AG and AD. However, visual inspection showed that the morphology of damages caused on AG bars was most important compared with the other steel bars. I

Published
2016

39. The current state of truancy reduction programs and opportunities for enhancement in Los Angeles County

Author

Gase, Lauren N., primary, Butler, Katherine, additional, Kuo, Tony, additional, Bodin, Lydia, additional, Byrdsong, Kristen, additional, Carter, Hellen, additional, Cochrane, William, additional, Cormier, Muriel, additional, Corral, Jesus, additional, Fitzgerald, Elizabeth, additional, Gomeztrejo, Jennifer, additional, Gutierrez, John, additional, and Holmes, Vincent, additional

Published
2015
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40. Abstract OT1-1-06: A phase I study of LDE225 in combination with docetaxel in patients with triple negative (TN) advanced breast cancer (ABC): GEICAM/2012-12 (EDALINE study)

Author

Martin, Miguel, primary, Ruiz-Borrego, Manuel, additional, Trigo, José M, additional, Antolin, Silvia, additional, Garcia-Saenz, Jose A, additional, Hernando, Andres, additional, Ocaña, Alberto, additional, Rojo, Federico, additional, Lopez-Tarruella, Sara, additional, Corral, Jesus, additional, Ribelles, Nuria, additional, Calvo, Lourdes, additional, Moreno, Fernando, additional, Caballero, Rosalia, additional, and Carrasco, Eva, additional

Published
2015
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41. Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors

Author

Sequist, Lecia V., Cassier, Phillippe, Varga, Andrea, Tabernero, Josep, Schellens, Jan H., Delord, Jean-Pierre, LoRusso, Patricia, Camidge, D. Ross, Hidalgo Medina, Manuel, Schuler, Martin, Campone, Mario, Tian, G. Gary, Wong, Steven, Corral, Jesus, Isaacs, Randi, Sen, Suman K., Porta, Diana Graus, Kulkarni, Swarupa G., Lefebvre, Caroline, Wolf, Juergen, Sequist, Lecia V., Cassier, Phillippe, Varga, Andrea, Tabernero, Josep, Schellens, Jan H., Delord, Jean-Pierre, LoRusso, Patricia, Camidge, D. Ross, Hidalgo Medina, Manuel, Schuler, Martin, Campone, Mario, Tian, G. Gary, Wong, Steven, Corral, Jesus, Isaacs, Randi, Sen, Suman K., Porta, Diana Graus, Kulkarni, Swarupa G., Lefebvre, Caroline, and Wolf, Juergen

Published
2014

42. Abstract CT326: Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors

Author

Sequist, Lecia V., primary, Cassier, Phillippe, additional, Varga, Andrea, additional, Tabernero, Josep, additional, Schellens, Jan H., additional, Delord, Jean-Pierre, additional, LoRusso, Patricia, additional, Camidge, D. Ross, additional, Medina, Manuel Hidalgo, additional, Schuler, Martin, additional, Campone, Mario, additional, Tian, G. Gary, additional, Wong, Steven, additional, Corral, Jesus, additional, Isaacs, Randi, additional, Sen, Suman K., additional, Porta, Diana Graus, additional, Kulkarni, Swarupa G., additional, Lefebvre, Caroline, additional, and Wolf, Jürgen, additional

Published
2014
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44. Phase I Pharmacokinetic and Pharmacodynamic Dose-Escalation Study of RG7160 (GA201), the First Glycoengineered Monoclonal Antibody Against the Epidermal Growth Factor Receptor, in Patients With Advanced Solid Tumors

Author

Paz-Ares, Luis G., primary, Gomez-Roca, Carlos, additional, Delord, Jean-Pierre, additional, Cervantes, Andres, additional, Markman, Ben, additional, Corral, Jesus, additional, Soria, Jean-Charles, additional, Bergé, Yann, additional, Roda, Desamparados, additional, Russell-Yarde, Fiona, additional, Hollingsworth, Simon, additional, Baselga, José, additional, Umana, Pablo, additional, Manenti, Luigi, additional, and Tabernero, Josep, additional

Published
2011
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47. Efficacy in patients with EGFR -positive non-small-cell lung cancer treated with dacomitinib who had skin adverse events: post hoc analyses from ARCHER 1050.

Author

Pu X, Li J, Zhang B, Zhang J, K Mok TS, Nakagawa K, Rosell R, Cheng Y, Zhou X, Miglorino MR, Niho S, Lee KH, Corral J, Pluzanski A, Li J, Linke R, Pan F, Tang Y, Tan W, and Wu L

Subjects
Humans, Female, Male, Aged, Middle Aged, Aged, 80 and over, Adult, Protein Kinase Inhibitors therapeutic use, Protein Kinase Inhibitors adverse effects, Progression-Free Survival, Treatment Outcome, Mutation, Antineoplastic Agents therapeutic use, Antineoplastic Agents adverse effects, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Quinazolinones adverse effects, Quinazolinones therapeutic use, Quinazolinones administration & dosage, ErbB Receptors antagonists & inhibitors, Lung Neoplasms drug therapy, Lung Neoplasms mortality, Lung Neoplasms pathology
Abstract

Aim: We investigated association between skin adverse events (AEs) and efficacy with dacomitinib in patients with EGFR -positive non-small-cell lung cancer (NSCLC). Methods: Post hoc analyses from ARCHER 1050 evaluated efficacy in patients who did and did not experience grade ≥2 skin AEs with dacomitinib. Landmark analyses were performed at 3 and 6 months. Results: In patients who had skin AEs (72.2%) vs. those who did not (27.7%), median progression-free survival was 16.0 vs. 9.2 months, median overall survival (OS) was 37.7 vs. 21.6 months, and objective response rate was 80.2 vs. 61.5%; OS was improved at 3 and 6 months landmark analyses. Conclusion: Presence of grade ≥2 skin AEs was associated with numerically improved efficacy and represents a valuable biomarker of treatment outcome with dacomitinib in patients with advanced NSCLC. Clinical Trial Registration: NCT01774721 (ClinicalTrials.gov).

Published
2024
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