1. Selenium Vacancy Engineering Using Bi 2 Se 3 Nanodots for Boosting Highly Efficient Photonic Hyperthermia.
- Author
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Wen D, Dong L, Li K, Du Y, Deng R, Feng J, Zhang H, and Wang D
- Subjects
- Animals, Antineoplastic Agents chemistry, Antineoplastic Agents radiation effects, Bismuth chemistry, Cattle, Cell Line, Tumor, Contrast Media chemistry, Contrast Media radiation effects, Density Functional Theory, Female, Folic Acid chemistry, Infrared Rays, Mice, Inbred BALB C, Models, Chemical, Neoplasms diagnostic imaging, Photoacoustic Techniques, Photothermal Therapy, Quantum Dots chemistry, Quantum Dots radiation effects, Selenium Compounds chemistry, Selenium Compounds radiation effects, Serum Albumin, Bovine chemistry, Mice, Antineoplastic Agents therapeutic use, Bismuth therapeutic use, Contrast Media therapeutic use, Neoplasms drug therapy, Quantum Dots therapeutic use, Selenium Compounds therapeutic use
- Abstract
Despite bismuth-based energy conversion nanomaterials having attracted extensive attention for nanomedicine, the nanomaterials suffer from major shortcomings including low tumor accumulation, long internal retention time, and undesirable photothermal conversion efficiency (PCE). To combat these challenges, bovine serum albumin and folic acid co-modified Bi
2 Se3 nanomedicine with rich selenium vacancies (abbreviated as VSe -BS) was fabricated for the second near-infrared (NIR-II) light-triggered photonic hyperthermia. More importantly, selenium vacancies on the crystal planes (0 1 5) and (0 1 11) of VSe -BS with similar formation energies could be distinctively observed via aberration-corrected scanning transmission electron microscopy images. The defect engineering endows VSe -BS with enhanced conductivity, making VSe -BS possess outstanding PCE (54.1%) in the NIR-II biowindow and desirable photoacoustic imaging performance. Tumor ablation studies indicate that VSe -BS possesses satisfactory therapeutic outcomes triggered by NIR-II light. These findings give rise to inspiration for further broadening the biological applications of defect engineering bismuth-based nanomaterials.- Published
- 2021
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