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19,430 results on '"Conservatoire national des arts et métiers (Cnam)"'

1. Une mise en perspective du sujet.

Author: Les entretiens d'Eva: Une seule terre, que deviennent les projets d'habitat? (Conservatoire National des Arts et Métiers (CNAM), Paris, France), Debaise, Didier, Les entretiens d'Eva: Une seule terre, que deviennent les projets d'habitat? (Conservatoire National des Arts et Métiers (CNAM), Paris, France), and Debaise, Didier
Abstract: info:eu-repo/semantics/nonPublished
Published: 2023

2. Patrimoine contemporain des sciences et techniques

Author: Conservatoire national des arts et métiers (CNAM)
Published: 2016

3. Guide d'échantillonnage de plantes potagères dans le cadre de diagnostics environnementaux

Author: Denys, S., Marot, F., Elreedy, S., Gobron, V., Dinant, S., Pinet, C., Dumat, C., Schwartz, Christophe, Jeannée, N., PROST, René, Pascal, M., Lemaitre, N., Leprieur, F., Mercat-Rommens, C., Tack, K., Cardenas, G., Douay, F., Barbaste, Mireille, Institut National de la Recherche Agronomique US 1118 Unité de Service Analyses Végétales et Environnementales, Institut National de la Recherche Agronomique UR 0251 Physico-chimie et Ecotoxicologie des Sols d'agrosystèmes contaminés, Institut National de la Recherche Agronomique UMR 1120 Sols et Environnement, Institut National de l'Environnement Industriel et des Risques, Agence de l'Environnement et de la Maîtrise de l'Energie, Agence Française de Sécurité Sanitaire de l'Environnement et du Travail, Agence Nationale pour la Gestion des Déchets Radioactifs, Conservatoire National des Arts et Métiers [CNAM], Ecole Nationale Supérieure Agronomique de Toulouse, Géovariances, Institut de Veille Sanitaire, Institut de Radioprotection et de Sureté Nucléaire, Institut Supérieur d'Agriculture de Lille (Groupe ISA), Institut National de l'Environnement Industriel et des Risques (INERIS), Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), Agence Française de Sécurité Sanitaire de l'Environnement et du Travail, Agence Nationale pour la Gestion des Déchets Radioactifs (ANDRA), Conservatoire National des Arts et Métiers [CNAM] (CNAM), École nationale supérieure agronomique de Toulouse [ENSAT], Laboratoire Sols et Environnement (LSE), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Geovariances, Unité de recherche Science du Sol (USS), Institut National de la Recherche Agronomique (INRA), Institut de Veille Sanitaire (INVS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut Supérieur d'Agriculture de Lille (ISA), and Unité de service et de recherches en analyses végétales et environnementales (USRAVE)
Subjects: stratégie, [SDV]Life Sciences [q-bio], plante potagère, industrie, relation so-lplante-atmosphère, échantillonnage, état sanitaire, environnement, contamination, interprétation, [SDE]Environmental Sciences, pollution, ComputingMilieux_MISCELLANEOUS
Abstract: National audience
Published: 2007

4. What is expected from universities by policies for excellence?

Author: Musselin, Christine and Conservatoire National des Arts et Métiers (CNAM)
Published: 2013

5. Steady-state and stability analysis of a population balance based nonlinear ice cream crystallization model

Author: Centre for systems engineering and applied mechanics [Louvain] (CESAME) ; Université Catholique de Louvain (UCL), CESAME ; Centre for systems engineering and applied mechanics [Louvain] (CESAME) ; Université Catholique de Louvain (UCL) - Université Catholique de Louvain (UCL), Génie des procédés frigorifiques (UR GPAN) ; Irstea, SP2 ; Ingénierie Procédés Aliments (GENIAL) ; Institut national de la recherche agronomique (INRA) - Conservatoire National des Arts et Métiers [CNAM] - AgroParisTech - Institut national de la recherche agronomique (INRA) - Conservatoire National des Arts et Métiers [CNAM] - AgroParisTech, Génie des procédés frigorifiques (UR GPAN) ; CEMAGREF, European Project : 212754, KBBE, FP7-KBBE-2007-1, CAFE(2008), Casenave, Céline, Dochain, Denis, Alvarez, Graciela, Benkhelifa, Hayat, Flick, Denis, Leducq, Denis, Centre for systems engineering and applied mechanics [Louvain] (CESAME) ; Université Catholique de Louvain (UCL), CESAME ; Centre for systems engineering and applied mechanics [Louvain] (CESAME) ; Université Catholique de Louvain (UCL) - Université Catholique de Louvain (UCL), Génie des procédés frigorifiques (UR GPAN) ; Irstea, SP2 ; Ingénierie Procédés Aliments (GENIAL) ; Institut national de la recherche agronomique (INRA) - Conservatoire National des Arts et Métiers [CNAM] - AgroParisTech - Institut national de la recherche agronomique (INRA) - Conservatoire National des Arts et Métiers [CNAM] - AgroParisTech, Génie des procédés frigorifiques (UR GPAN) ; CEMAGREF, European Project : 212754, KBBE, FP7-KBBE-2007-1, CAFE(2008), Casenave, Céline, Dochain, Denis, Alvarez, Graciela, Benkhelifa, Hayat, Flick, Denis, and Leducq, Denis
Abstract: International audience, The process of crystallization can be modelled by a population balance equation coupled with an energy balance equation. Such models are highly complex to study due to the infinite dimensional and nonlinear characteristics, especially when all the phenomena of nucleation, growth and breakage are considered. In the present paper, we have performed the stability analysis on a reduced order model obtained by the method of moments, which remains still highly complex. The considered model has been developed by the Cemagref and validated on experimental data. After computation, we get a scalar equation whose solutions correspond to the equilibrium points of the system. This equation is finally solved numerically for a concrete physical configuration of the crystallizer. We show that in most instances, there is only one steady state. The possibility of multiple steady-states is discussed.

6. La Voiture à vapeur de Cugnot - 1770

Author: Conservatoire National des Arts et Métiers (CNAM) and Conservatoire National des Arts et Métiers (CNAM)
Abstract: 1 vol. (12 p.) : ill.; 21 cm
Published: 1956

7. Structures nouvelles en architecture : [Exposition, musée des techniques, Paris, avril 1965]

Author: Institut Technique et Plastique de Recherches sur les Voiles Prétendues, Conservatoire National des Arts et Métiers (CNAM), Institut Technique et Plastique de Recherches sur les Voiles Prétendues, and Conservatoire National des Arts et Métiers (CNAM)
Abstract: 1 vol. (112 p.) : ill. ; 21 cm
Published: 1965

8. Antenne RFID UHF pour applications en champ proche et champ lointain

Author: Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC) ; Université de Savoie - Université Joseph Fourier - Grenoble I - Institut National Polytechnique de Grenoble (INPG) - CNRS, Laboratoire National de Métrologie et d'Essais - Institut National de Métrologie (LNE- INM) ; Conservatoire National des Arts et Métiers [CNAM] : EA2367, Laboratoire de Conception et d'Intégration des Systèmes (LCIS) ; Université Pierre-Mendès-France - Grenoble II - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Coehlo De Souza, Aline, Duroc, Yvan, Vuong, Tan-Phu, Luce, Alexandre, Perdereau, Jacques, Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC) ; Université de Savoie - Université Joseph Fourier - Grenoble I - Institut National Polytechnique de Grenoble (INPG) - CNRS, Laboratoire National de Métrologie et d'Essais - Institut National de Métrologie (LNE- INM) ; Conservatoire National des Arts et Métiers [CNAM] : EA2367, Laboratoire de Conception et d'Intégration des Systèmes (LCIS) ; Université Pierre-Mendès-France - Grenoble II - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Coehlo De Souza, Aline, Duroc, Yvan, Vuong, Tan-Phu, Luce, Alexandre, and Perdereau, Jacques
Abstract: National audience

9. A Near-Field and Far-Field Antenna for UHF RFID Applications

Author: Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC) ; Université de Savoie - Université Joseph Fourier - Grenoble I - Institut National Polytechnique de Grenoble (INPG) - CNRS, Laboratoire National de Métrologie et d'Essais - Institut National de Métrologie (LNE- INM) ; Conservatoire National des Arts et Métiers [CNAM] : EA2367, Laboratoire de Conception et d'Intégration des Systèmes (LCIS) ; Université Pierre-Mendès-France - Grenoble II - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Coehlo De Souza, Aline, Duroc, Yvan, Vuong, Tan-Phu, Luce, Alexandre, Perdereau, Jacques, Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC) ; Université de Savoie - Université Joseph Fourier - Grenoble I - Institut National Polytechnique de Grenoble (INPG) - CNRS, Laboratoire National de Métrologie et d'Essais - Institut National de Métrologie (LNE- INM) ; Conservatoire National des Arts et Métiers [CNAM] : EA2367, Laboratoire de Conception et d'Intégration des Systèmes (LCIS) ; Université Pierre-Mendès-France - Grenoble II - Institut Polytechnique de Grenoble - Grenoble Institute of Technology, Coehlo De Souza, Aline, Duroc, Yvan, Vuong, Tan-Phu, Luce, Alexandre, and Perdereau, Jacques
Abstract: International audience

10. Introduction à la première conférence de Document numérique et Société

Author: Institut national des techniques de la documentation (INTD-CNAM) ; Conservatoire National des Arts et Métiers [CNAM], Laboratoire Paragraphe ; Université Paris VIII - Vincennes Saint-Denis, Centre d'histoire culturelle des sociétés contemporaines (CHCSC) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Chartron, Ghislaine, Broudoux, Evelyne, Institut national des techniques de la documentation (INTD-CNAM) ; Conservatoire National des Arts et Métiers [CNAM], Laboratoire Paragraphe ; Université Paris VIII - Vincennes Saint-Denis, Centre d'histoire culturelle des sociétés contemporaines (CHCSC) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Chartron, Ghislaine, and Broudoux, Evelyne
Abstract: International audience, La première édition de la conférence « Document numérique et Société » (DocSoc) a été lancée dans le cadre de la Semaine du Document Numérique 2006 (SDN 06). Cette conférence s'inscrit dans le prolongement de l'action spécifique «Modèles de publication sur le web » et de l'Atelier « Auteurs » du RTP-DOC/CNRS (2002-2005). Les actes de cette conférence ont été publiés aux éditions de l'ADBS. http://www.adbs.fr/document-numerique-et-societe-19210.htm?RH=ACCUEIL

11. Radio sur fibre pour un réseau local domestique millimétrique

Author: Orange Labs [Lannion] ; France Télécom, Systèmes Rayonnants Complexes (SRC) ; Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Electronique, Systèmes de communication et Microsystèmes (ESYCOM) ; Conservatoire National des Arts et Métiers [CNAM] - Université Paris-Est Marne-la-Vallée (UPEMLV) - ESIEE, Systèmes Rayonnants Complexes (SRC) ; Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Université de Nantes, Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest, Lab-STICC_TB_MOM_PIM ; Laboratoire d'Electronique et Systèmes de Télécommunications (LEST) ; CNRS - Université de Bretagne Occidentale (UBO) - Ecole Nationale Supérieure des Télécommunications de Bretagne - CNRS - Université de Bretagne Occidentale (UBO) - Ecole Nationale Supérieure des Télécommunications de Bretagne - Traitement Algorithmique et Matériel de la Communication, de l'Information et de la Connaissance (TAMCIC) ; CNRS - Ecole Nationale Supérieure des Télécommunications de Bretagne - CNRS - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - CNRS - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, ACOME ; ACOME, SIRADEL ; siradel, NIJI ; NIJI, DGE FUI, Projet ORIGIN, Guillory, Joffray, Tanguy, Eric, Pizzinat, Anna, Charbonnier, Benoit, Meyer, Sylvain, Li, Hong Wu, Algani, Catherine, Bouffant, O., Delas, G., Chousseaud, Anne, Brunet, Marc, Lirzin, Guillaume, Polleux, Jean-Luc, Ney, Michel, BOURREAU, Daniel, Kernfelt, C., Canepa, C., Gougeon, G., Gouin, V., Orange Labs [Lannion] ; France Télécom, Systèmes Rayonnants Complexes (SRC) ; Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Electronique, Systèmes de communication et Microsystèmes (ESYCOM) ; Conservatoire National des Arts et Métiers [CNAM] - Université Paris-Est Marne-la-Vallée (UPEMLV) - ESIEE, Systèmes Rayonnants Complexes (SRC) ; Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Université de Nantes, Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest, Lab-STICC_TB_MOM_PIM ; Laboratoire d'Electronique et Systèmes de Télécommunications (LEST) ; CNRS - Université de Bretagne Occidentale (UBO) - Ecole Nationale Supérieure des Télécommunications de Bretagne - CNRS - Université de Bretagne Occidentale (UBO) - Ecole Nationale Supérieure des Télécommunications de Bretagne - Traitement Algorithmique et Matériel de la Communication, de l'Information et de la Connaissance (TAMCIC) ; CNRS - Ecole Nationale Supérieure des Télécommunications de Bretagne - CNRS - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - CNRS - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, ACOME ; ACOME, SIRADEL ; siradel, NIJI ; NIJI, DGE FUI, Projet ORIGIN, Guillory, Joffray, Tanguy, Eric, Pizzinat, Anna, Charbonnier, Benoit, Meyer, Sylvain, Li, Hong Wu, Algani, Catherine, Bouffant, O., Delas, G., Chousseaud, Anne, Brunet, Marc, Lirzin, Guillaume, Polleux, Jean-Luc, Ney, Michel, BOURREAU, Daniel, Kernfelt, C., Canepa, C., Gougeon, G., and Gouin, V.
Abstract: National audience, Le projet FUI ORIGIN (Optical-Radio Infrastructure for Gigabit/s Indoor Networks) adresse le marché du Réseau Local Domestique pour lequel il propose une nouvelle infrastructure à très haut débit associant un câblage à fibre optique avec une diffusion radio 60GHz. Les premiers tests de cette infrastructure ont donné des résultats probants : un lien Radio sur Fibre en fréquence intermédiaire étendant la portée d'une transmission radio millimétrique est ici proposé et caractérisé complètement en termes d'EVM. Ce concept est validé par l'utilisation de produits commerciaux Wireless HD. Les études se poursuivent pour intégrer les systèmes optique-microondes en utilisant des composants bas coûts et innovants, comme les phototransistors SiGe/Si et des VCSEL analogiques.

12. Liaison sans fils à 60 GHz et réseau domestique multi-gigabit/s basé sur une infrastructure radio sur fibre bas coût

Author: Orange Labs [Lannion] ; France Télécom, Electronique, Systèmes de communication et Microsystèmes (ESYCOM) ; Conservatoire National des Arts et Métiers [CNAM] - Université Paris-Est Marne-la-Vallée (UPEMLV) - ESIEE, Lab-STICC_TB_MOM_PIM ; Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest, Lab-STICC_TB_MOM_DIM ; Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, Systèmes Rayonnants Complexes (SRC) ; Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Systèmes Rayonnants Complexes (SRC) ; Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Université de Nantes, ACOME ; ACOME, SIRADEL ; siradel, NIJI ; NIJI, INNOPTICS ; Innoptics, Pizzinat, Anna, Charbonnier, Benoit, Bouffant, O., Le Coq, D., Evanno, N., Polleux, Jean-Luc, Rosales, Marc, Viana, C., Algani, Catherine, Billabert, Anne-Laure, Faci, Salim, Bourreau, Daniel, Paugam, Y., Karnfelt, Camilla, Ney, Michel, Brunet, Marc, Lirzin, Guillaume, Tanguy, Eric, Chousseaud, Anne, Li, Hong Wu, Canepa, C., Gougeon, G., Poinen, J., Sun, C., Lecocq, V., Denet, S., Orange Labs [Lannion] ; France Télécom, Electronique, Systèmes de communication et Microsystèmes (ESYCOM) ; Conservatoire National des Arts et Métiers [CNAM] - Université Paris-Est Marne-la-Vallée (UPEMLV) - ESIEE, Lab-STICC_TB_MOM_PIM ; Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest, Lab-STICC_TB_MOM_DIM ; Département Micro-Ondes (MO) ; Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Télécom Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC) ; CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Télécom Bretagne - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Institut Mines-Télécom - PRES Université Européenne de Bretagne (UEB) - Ecole Nationale d'Ingénieurs de Brest - CNRS - Université de Bretagne Occidentale (UBO) - Université de Bretagne Sud (UBS) - Institut Supérieur des Sciences et Technologies de Brest (ISSTB) - ENSTA Bretagne - Ecole Nationale d'Ingénieurs de Brest, Systèmes Rayonnants Complexes (SRC) ; Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes, Systèmes Rayonnants Complexes (SRC) ; Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - CNRS - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Institut de Recherche en Electrotechnique et Electronique de Nantes Atlantique (IREENA) ; Université de Nantes - Université de Nantes - Institut d'Electronique et de Télécommunications de Rennes (IETR) ; CNRS - Université de Nantes - SUPELEC - Université de Rennes 1 - Institut National des Sciences Appliquées (INSA) - Rennes - Université de Nantes, ACOME ; ACOME, SIRADEL ; siradel, NIJI ; NIJI, INNOPTICS ; Innoptics, Pizzinat, Anna, Charbonnier, Benoit, Bouffant, O., Le Coq, D., Evanno, N., Polleux, Jean-Luc, Rosales, Marc, Viana, C., Algani, Catherine, Billabert, Anne-Laure, Faci, Salim, Bourreau, Daniel, Paugam, Y., Karnfelt, Camilla, Ney, Michel, Brunet, Marc, Lirzin, Guillaume, Tanguy, Eric, Chousseaud, Anne, Li, Hong Wu, Canepa, C., Gougeon, G., Poinen, J., Sun, C., Lecocq, V., and Denet, S.
Abstract: National audience, Le projet FUI8 ORIGIN (Optical Radio Infrastructure for Gigabit/s Indoor Network) s'adresse au marché du Réseau Local Domestique (RLD) en proposant une infrastructure bas coût qui combine l'efficacité de la fibre optique pour la diffusion radio avec les avantages d'une transmission sans fils. Les premières réalisations et les tests réussis sont présentés dans ce papier.

13. Validation of the IMPACT-III Questionnaire in French Children With Inflammatory Bowel Disease

Author: Jérémy Vanhelst, Laurent Béghin, Elodie Drumez, Djamal Djeddi-Dine, Dominique Tuck, Stéphanie Coopman, Frédéric Gottrand, Delphine Ley, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Pediatrics, Perinatology and Child Health, Gastroenterology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Objectives: This study assessed the reliability and validity of the IMPACT-III questionnaire, a health-related quality of life (HRQoL) instrument, in French children with inflammatory bowel disease (IBD).Methods: Eighty-four children and adolescents (45 boys, aged 14.3 ± 2.7 years) were included in a validation study of the IMPACT-III questionnaire. Patients completed 2 questionnaires for measuring HRQoL: the IMPACT-III and the Pediatric Quality of Life Inventory 4.0 Generic Core Scale (PedsQL). Internal consistency was assessed using Cronbach α. Factor analysis was performed on data from the IMPACT-III to help construct domains. Concurrent validity was assessed by calculating Spearman correlation coefficients.Results: Cronbach α for the PedsQL total score was good (0.89). The most robust factor solution was a 3-domain structure: (a) Concerns, (b) Body Image and Physical Condition, and (c) Symptoms and Socializing. All domains had good reliability (0.674-0.863). Only 2 items had to be removed. Discriminant validity was demonstrated by significant differences ( P < 0.001) in median IMPACT-III scores between inactive and active disease for the total score (83.3 vs 72.0), and for Concerns ( P < 0.002) and Symptoms and Socializing ( P < 0.001).Conclusions: These results suggest that IMPACT-III appears to be a useful instrument for measuring HRQoL in French children with IBD.
Published: 2023
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14. Associations of childhood adiposity with adult intima–media thickness and inflammation: a 20-year longitudinal population-based cohort

Author: Fujikawa, Tomona, Kobayashi, Masatake, Wagner, Sandra, Duarte, Kevin, Scherdel, Pauline, Heude, Barbara, Dupont, Vincent, Bozec, Erwan, Bresso, Emmanuel, Zannad, Faiez, Rossignol, Patrick, Girerd, Nicolas, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 6 : ORCHAD - Origines précoces de la santé du développement de l'enfant (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Centre Hospitalier Universitaire de Reims (CHU Reims), ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), European Project, European Project: 305507,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,HOMAGE(2013), and European Project: ERA-CVD/0001/2016,MINOTAUR
Subjects: inflammation, Physiology, [SDV]Life Sciences [q-bio], childhood adiposity, Internal Medicine, biomarkers, Cardiology and Cardiovascular Medicine, carotid intima–media thickness
Abstract: International audience; Background: The associations between childhood adiposity and adult increased carotid intima-media thickness (cIMT) have been well established, which might be corroborated by the association between adiposity in children and inflammation in adults. However, longitudinal data regarding biological pathways associated with childhood adiposity are lacking.Methods: The current study included participants from the STANISLAS cohort who had adiposity measurements at age 5-18 years [ N = 519, mean (SD) age, 13.0 (2.9) years; 46.4% male], and who were measured with cIMT, vascular-related and metabolic-related proteins at a median follow-up of 19 ± 2 years. BMI, waist-to-height ratio and waist circumference were converted to age-specific and sex-specific z -scores.Results: A minority of children were overweight/obese (16.2% overweight-BMI z -score >1; 1.3% obesity- z -score >2). Higher BMI, waist-height ratio and waist circumference in children were significantly associated with greater adult cIMT in univariable analysis, although not after adjusting for C-reactive protein. These associations were more pronounced in those with consistently high adiposity status from childhood to middle adulthood. Participants with higher adiposity during childhood (BMI or waist-height ratio) had higher levels of insulin-like growth factor-binding protein-1, protein-2, matrix metalloproteinase-3, osteopontin, hemoglobin and C-reactive protein in adulthood. Network analysis showed that IL-6, insulin-like growth factor-1 and fibronectin were the key proteins associated with childhood adiposity.Conclusion: In a population-based cohort followed for 20 years, higher BMI or waist-to-height ratio in childhood was significantly associated with greater cIMT and enhanced levels of proteins reflective of inflammation, supporting the importance of inflammation as progressive atherosclerosis in childhood adiposity.
Published: 2022
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15. An AI-Empowered Framework for Cross-Layer Softwarized Infrastructure State Assessment

Author: Alessio Diamanti, Jose Manuel Sanchez Vilchez, Stefano Secci, Orange Labs, CEDRIC. Réseaux et Objets Connectés (CEDRIC - ROC), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Orange Labs [Chatillon], ANR-18-CE25-0011,CANCAN,Adaptation basée sur le contenu et le contexte dans les réseaux mobiles(2018), and European Project: 101015922,H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT),AI@EDGE(2021)
Subjects: [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Computer Networks and Communications, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2022
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16. Ellipsoid-Based Interval Estimation for Lipschitz Nonlinear Systems

Author: Wenhan Zhang, Zhenhua Wang, Tarek Raissi, Yi Shen, Harbin Institute of Technology (HIT), CEDRIC. Traitement du signal et architectures électroniques (CEDRIC - LAETITIA), Centre d'études et de recherche en informatique et communications (CEDRIC), and Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)
Subjects: 0209 industrial biotechnology, 020901 industrial engineering & automation, Control and Systems Engineering, 02 engineering and technology, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science Applications
Abstract: International audience
Published: 2022
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17. Wasserstein Loss for Semantic Editing in the Latent Space of GANs

Author: Doubinsky, Perla, Audebert, Nicolas, Crucianu, Michel, Le Borgne, Hervé, CEDRIC. Données complexes, apprentissage et représentations (CEDRIC - VERTIGO), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), ANR-20-THIA-0002,AHEAD,Intelligence artificielle pour la santé, la physqiue, les transports et la sécurité(2020), and European Project: H2020-951911,H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT),AI4Media(2020)
Subjects: FOS: Computer and information sciences, image edition, Artificial Intelligence (cs.AI), Computer Science - Artificial Intelligence, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition, Wasserstein distance, GAN Wasserstein distance image edition, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], GAN
Abstract: The latent space of GANs contains rich semantics reflecting the training data. Different methods propose to learn edits in latent space corresponding to semantic attributes, thus allowing to modify generated images. Most supervised methods rely on the guidance of classifiers to produce such edits. However, classifiers can lead to out-of-distribution regions and be fooled by adversarial samples. We propose an alternative formulation based on the Wasserstein loss that avoids such problems, while maintaining performance on-par with classifier-based approaches. We demonstrate the effectiveness of our method on two datasets (digits and faces) using StyleGAN2.
Published: 2023
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18. Centenarians consistently present a younger epigenetic age than their chronological age with four epigenetic clocks based on a small number of CpG sites

Author: Antoine Daunay, Lise M. Hardy, Yosra Bouyacoub, Mourad Sahbatou, Mathilde Touvier, Hélène Blanché, Jean-François Deleuze, Alexandre How-Kit, Fondation Jean Dausset CEPH, Laboratory of Excellence GENMED [Paris] (Medical Genomics), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de Recherche en Génomique Humaine (CNRGH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Bertram, Marie-Liesse
Subjects: Aged, 80 and over, Epigenomics, Aging, [SDV]Life Sciences [q-bio], Cell Biology, DNA Methylation, Epigenesis, Genetic, [SDV] Life Sciences [q-bio], pyrosequencing, longevity, Centenarians, Humans, CpG Islands, DNAmage, epigenetic clock
Abstract: International audience; Aging is a progressive time-dependent biological process affecting differentially individuals, who can sometimes present exceptional longevity. Epigenetic alterations are one of the hallmarks of aging, which comprise the epigenetic drift and clock at DNA methylation level. In the present study, we estimated the DNA methylation-based age (DNAmage) using four epigenetic clocks based on a small number of CpGs in French centenarians and semi-supercentenarians (CSSC, n=214) as well as nonagenarians' and centenarians' offspring (NCO, n=143) compared to individuals from the French general population (CG, n=149). DNA methylation analysis of the nine CpGs included in the epigenetic clocks showed high correlation with chronological age (-0.66>R>0.54) and also the presence of an epigenetic drift for four CpGs that was only visible in CSSC. DNAmage analysis showed that CSSC and to a lesser extend NCO present a younger DNAmage than their chronological age (15-28.5 years for CSSC, 4.4-11.5 years for NCO and 4.2-8.2 years for CG), which were strongly significant in CSSC compared to CG (p-values
Published: 2022
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19. Impact of immune checkpoint inhibitors on the management of locally advanced or metastatic non-small cell lung cancer in real-life practice in patients initiating treatment between 2015 and 2018 in France and Germany

Author: Griesinger, Frank, Pérol, Maurice, Girard, Nicolas, Durand-Zaleski, Isabelle S., Zacharias, Stefan, Bosquet, Lise, Jänicke, Martina, Quantin, Xavier, Groth, Annika, Fleitz, Annette, Calleja, Alan, Patel, Sonya, Lacoin, Laure, Daumont, Melinda Manley, Penrod, John R., Carroll, Robert, Waldenberger, Daniela, Reynaud, Dorothée, Thomas, Michael J., Chouaid, Christos, University of Oldenburg, Centre Léon Bérard [Lyon], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Curie [Paris], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), UNICANCER, Institut du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), German Center for Lung Research, Centre Hospitalier Intercommunal de Créteil (CHIC), Amgen, Bristol-Myers Squibb, BMS, Eli Lilly and Company, Pfizer, AstraZeneca, Novartis, Roche, Celgene, AbbVie, Boehringer Ingelheim, Takeda Pharmaceutical Company, TPC, Merck Sharp and Dohme, MSD, Cilag, LATITUDE (AXON Communications) provided medical writing services on behalf of the authors and Bristol Myers Squibb Pharmaceuticals Ltd. The authors thank the centres involved in the ESME-AMLC programme for providing the data and each ESME local coordinator for managing the project at the local level. Moreover, the authors also thank the central coordination team of Unicancer and the ESME-AMLC Scientific Committee members for their ongoing support. The authors thank all patients, physicians and study teams participating in the CRISP registry, and the CRISP Executive Committee for their medical leadership., CRISP is an AIO study (no. AIO-TRK-0315) conducted by AIO-Studien-gGmbH (sponsor) in cooperation with iOMEDICO (conception, project management and analysis) and supported by grants from Amgen Ltd., AstraZeneca GmbH, Boehringer Ingelheim Pharma GmbH & Co. KG, Bristol Myers Squibb GmbH & Co. KGaA, Celgene GmbH, Janssen-Cilag GmbH, Lilly Deutschland GmbH, Merck Sharp & Dohme GmbH, Novartis Pharma GmbH, Pfizer Pharma GmbH, Roche Pharma AG, and Takeda Pharma Vertriebs GmbH & Co. KG., Michael Thomas reports honoraria for scientific meetings from Abbvie, Amgen, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Chugai, Daichi Sankyo, GlaxoSmithKline, Janssen, Lilly, Merck, MSD, Novartis, Pfizer, Roche, Sanofi and Takeda, travel support from AbbVie, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Chugai, Lilly, MSD, Novartis, Pfizer, Roche and Takeda, honoraria for advisory boards from AbbVie, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Chugai, Janssen, Lilly, MSD, Novartis, Pfizer, Roche and Takeda, and institutional research grants from AstraZeneca, Bristol Myers Squibb, Roche and Takeda., The ESME-AMLC database received financial support from an industrial consortium (AstraZeneca, Merck Sharp & Dohme, Bristol Myers Squibb, Amgen and Roche). Unicancer manages the ESME database (i.e. data collection and analysis) independently., Christos Chouaid reports grants, personal fees and non-financial support from Amgen, AstraZeneca, Aventis, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, GlaxoSmithKline, Lilly, Merck Sharp & Dohme, Novartis, Pfizer, Roche, Sanofi and Takeda outside the submitted work., Annika Groth reports grants from Amgen, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Janssen-Cilag, Lilly, Merck Sharp & Dohme, Novartis, Pfizer, Roche, and Takeda to her employer AIO-Studien-gGmbH., and HAL UVSQ, Équipe
Subjects: Real-world evidence, Pulmonary and Respiratory Medicine, Cancer Research, Lung Neoplasms, [SDV]Life Sciences [q-bio], Receptor Protein-Tyrosine Kinases, I-O Optimise, [SDV] Life Sciences [q-bio], ErbB Receptors, Oncology, Carcinoma, Non-Small-Cell Lung, Humans, Prospective Studies, Advanced non-small cell lung cancer, Immune Checkpoint Inhibitors, Retrospective Studies
Abstract: International audience; Objectives: To describe the impact of immune checkpoint inhibitors (ICIs) on treatment patterns and survival outcomes in patients with locally advanced or metastatic non-small cell lung cancer (aNSCLC) in France and Germany. Materials and Methods: Patients with aNSCLC without known ALK or EGFR mutations receiving first-line (1L) therapy were included from (i) the retrospective Epidemiological-Strategy and Medical Economics Advanced and Metastatic Lung Cancer cohort (ESME-AMLC, France; 2015–2018) and (ii) the prospective Clinical Research platform Into molecular testing, treatment and outcome of non-Small cell lung carcinoma Patients platform (CRISP, Germany; 2016–2018). Analyses were stratified according to histology. Survival outcomes were estimated using Kaplan–Meier methodology and stratified by year of 1L therapy. Data sources were analysed separately. Results: In ESME-AMLC and CRISP, 8,046 and 2,359 patients were included in the study, respectively. In both countries, approximately 20 % of all patients received pembrolizumab monotherapy as 1L treatment in 2018. In ESME-AMLC, the proportion receiving an ICI over the course of treatment (any line) increased from 42.2 % (2015) to 56.1 % (2018) in patients with squamous histology, and 28.9 % to 51.9 % with non-squamous/other; in CRISP, it increased from 50.6 % (2016) to 65.2 % (2018) with squamous histology, and 40.8 % to 62.7 % with non-squamous/other. Two-year overall survival from 1L initiation was 36.8 % and 25.6 % in the squamous cohorts and 36.5 % and 30.8 % in the non-squamous/other cohorts in ESME-AMLC and CRISP, respectively. No significant change in overall survival was observed over time; however, the follow-up time available was limited in the later years of the analysis. Conclusion: The results of this joint research from two large clinical databases in France and Germany demonstrate the growing use of ICIs in the management of aNSCLC. Future analyses will allow for the evaluation of the impact of ICIs on long-term survival of patients with aNSCLC.
Published: 2022
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20. Multi-attribute balanced sampling for disentangled GAN controls

Author: Doubinski, Perla, Audebert, Nicolas, Crucianu, Michel, Le Borgne, Hervé, CEDRIC. Données complexes, apprentissage et représentations (CEDRIC - VERTIGO), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Département Intelligence Ambiante et Systèmes Interactifs (DIASI), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, ANR-20-THIA-0002,AHEAD,Intelligence artificielle pour la santé, la physqiue, les transports et la sécurité(2020), European Project: H2020-951911,H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT),AI4Media(2020), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Vision and Pattern Recognition (cs.CV), GAN, generative models, latent space, face editing, Computer Science - Computer Vision and Pattern Recognition, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Latent space, Machine Learning (cs.LG), [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], Artificial Intelligence (cs.AI), Artificial Intelligence, Signal Processing, GANs, Image editing, Latent space, [INFO]Computer Science [cs], Image editing, Computer Vision and Pattern Recognition, GANs, Software
Abstract: International audience; Various controls over the generated data can be extracted from the latent space of a pre-trained GAN, as it implicitly encodes the semantics of the training data. The discovered controls allow to vary semantic attributes in the generated images but usually lead to entangled edits that affect multiple attributes at the same time. Supervised approaches typically sample and annotate a collection of latent codes, then train classifiers in the latent space to identify the controls. Since the data generated by GANs reflects the biases of the original dataset, so do the resulting semantic controls. We propose to address disentanglement by subsampling the generated data to remove over-represented co-occuring attributes thus balancing the semantics of the dataset before training the classifiers. We demonstrate the effectiveness of this approach by extracting disentangled linear directions for face manipulation on two popular GAN architectures, PGGAN and StyleGAN, and two datasets, CelebAHQ and FFHQ. We show that this approach outperforms state-of-the-art classifier-based methods while avoiding the need for disentanglement-enforcing post-processing.
Published: 2022
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21. Robust Access Point Clustering in Edge Computing Resource Optimization

Author: Nour-El-Houda Yellas, Selma Boumerdassi, Alberto Ceselli, Bilal Maaz, Stefano Secci, CEDRIC. Réseaux et Objets Connectés (CEDRIC - ROC), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Università degli Studi di Milano = University of Milan (UNIMI), AMI-5G ENE5AI (plan de relance), ANR-18-CE25-0011,CANCAN,Adaptation basée sur le contenu et le contexte dans les réseaux mobiles(2018), and European Project: 101015922,H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT),AI@EDGE(2021)
Subjects: RAN virtualization, MEC Resource Allocation, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Access Point Clustering, Multi-access Edge Computing, Computer Networks and Communications, [INFO]Computer Science [cs], Electrical and Electronic Engineering
Abstract: International audience; Multi-access Edge Computing (MEC) technology has emerged to overcome traditional cloud computing limitations, challenged by the new 5G services with heavy and heterogeneous requirements on both latency and bandwidth. In this work, we tackle the problem of clustering access points in MEC environments, introducing a set of clustering models to be deployed at the pre-provisioning phase. We go through extensive simulations on real-world traffic demands to evaluate the performance of the proposed solutions. In addition, we show how MEC hosts capacity violation can be decreased when integrating access points clustering into the orchestration model, by investigating on solution accuracy when applied on heldout users traffic demands. The obtained results show that our approach outperforms two state-of-the-art algorithms, reducing both memory usage and execution time, by 46% and 50%, respectively, in comparison to a baseline algorithm. It surpasses the two methods in gaining control over MEC hosts capacity usage for different maximum achieved occupancy levels on MEC hosts.
Published: 2022
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22. Monitoring sick leave data for early detection of influenza outbreaks

Author: David R M Smith, Jonathan Bastard, Pearl Anne Ante-Testard, Oumou Salama Daouda, Laura Temime, Tom Duchemin, Helene Neynaud, Kévin Jean, Audrey Duval, Mounia N. Hocine, Rania Assab, Narimane Nekkab, William Dab, Radowan Lounissi, Jérôme-Philippe Garsi, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Malakoff Humanis, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur [Paris] (IP), Malaria : parasites et hôtes - Malaria : parasites and hosts, TD PhD is funded by Association Nationale de la Recherche et de la Technologie and Malakoff Humanis. JB PhD is funded by the INCEPTION project (PIA/ANR-16-CONV-0005). PAAT PhD is funded by INSERM-ANRS (France Recherche Nord & Sud Sida-HIV Hépatites), grant number ANRS-12377 B104. DS PhD is funded by a Canadian Institutes of Health Research Doctoral Foreign Study Award (Funding Reference Number 164263) as well as the French government through its National Research Agency project SPHINX-17-CE36–0008-01., ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), ANR-17-CE36-0008,SPHINx,Diffusion de pathogènes au sein des réseaux de soins : une étude de modélisation(2017), TD is supported by Association Nationale de la Recherche et de la Technologie and Malakoff Humanis. JB is supported by the INCEPTION project (PIA/ANR-16-CONV-0005) PAA is supported by INSERM-ANRS (France Recherche Nord & Sud Sida-HIV Hepatites), grant number ANRS-12377 B104 DS is supported by a Canadian Institutes of Health Research Doctoral Foreign Study Award (Funding Reference Number 164263) as well as the French government through its National Research Agency project SPHINX-17-CE36-0008-01., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut Pasteur [Paris], Hocine, Mounia N., Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs - - INCEPTION2016 - ANR-16-CONV-0005 - CONV - VALID, and Diffusion de pathogènes au sein des réseaux de soins : une étude de modélisation - - SPHINx2017 - ANR-17-CE36-0008 - AAPG2017 - VALID
Subjects: Sick-leave, MESH: Influenza, Human / epidemiology, MESH: Public Health Surveillance / methods, 010501 environmental sciences, 01 natural sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Absenteeism, MESH: Sick Leave, Medicine, Public Health Surveillance, MESH: Epidemics, 030212 general & internal medicine, MESH: Incidence, Workplace, MESH: Sentinel Surveillance, MESH: Workplace, MESH: France / epidemiology, [STAT.ME] Statistics [stat]/Methodology [stat.ME], Surveillance, MESH: Middle Aged, Incidence, Middle Aged, Infectious Diseases, Sick leave, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, France, Sick Leave, 0305 other medical science, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Research Article, MESH: Absenteeism, Surveillance Methods, Early detection, Influenza epidemics, Primary care, MESH: Insurance, Health, Sensitivity and Specificity, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Environmental health, Outbreak detection, Influenza, Human, Health insurance, Humans, lcsh:RC109-216, Epidemics, MESH: Influenza, Human / virology, 0105 earth and related environmental sciences, Retrospective Studies, 030505 public health, Insurance, Health, Models, Statistical, MESH: Humans, business.industry, Outbreak, MESH: Retrospective Studies, Influenza, MESH: Sensitivity and Specificity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Sentinel Surveillance, MESH: Models, Statistical
Abstract: Background Workplace absenteeism increases significantly during influenza epidemics. Sick leave records may facilitate more timely detection of influenza outbreaks, as trends in increased sick leave may precede alerts issued by sentinel surveillance systems by days or weeks. Sick leave data have not been comprehensively evaluated in comparison to traditional surveillance methods. The aim of this paper is to study the performance and the feasibility of using a detection system based on sick leave data to detect influenza outbreaks. Methods Sick leave records were extracted from private French health insurance data, covering on average 209,932 companies per year across a wide range of sizes and sectors. We used linear regression to estimate the weekly number of new sick leave spells between 2016 and 2017 in 12 French regions, adjusting for trend, seasonality and worker leaves on historical data from 2010 to 2015. Outbreaks were detected using a 95%-prediction interval. This method was compared to results from the French Sentinelles network, a gold-standard primary care surveillance system currently in place. Results Using sick leave data, we detected 92% of reported influenza outbreaks between 2016 and 2017, on average 5.88 weeks prior to outbreak peaks. Compared to the existing Sentinelles model, our method had high sensitivity (89%) and positive predictive value (86%), and detected outbreaks on average 2.5 weeks earlier. Conclusion Sick leave surveillance could be a sensitive, specific and timely tool for detection of influenza outbreaks.
Published: 2023
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23. De l’histoire numérique à l’histoire données ?

Author: Mouza, Cédric Du, Lamassé, Stéphane, Rygiel, Philippe, CEDRIC. Ingénierie des Systèmes d'Information et de Décision (CEDRIC - ISID), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), PIREH, Université Paris 1 Panthéon-Sorbonne (UP1), LAboratoire de Recherche Historique Rhône-Alpes - UMR5190 (LARHRA), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Subjects: sources, numérique, histoire, [SHS.HIST]Humanities and Social Sciences/History, données, documentation
Abstract: International audience; Les historiens ont produit et analysé rigoureusement l’information bien avant l’émergence du big data et l’ère numérique. Cependant, les transformations actuelles, qui voient l’accumulation d’importants gisements de données historiques, créent de nouveaux défis et de nouvelles opportunités sur lesquelles nous revenons ici. En effet, le domaine des sciences historiques manque d’une formalisation stricte des caractéristiques des données, et aucune taxonomie ou réflexion systématique sur la nature des données n’a été établie ou publiée. À partir de travaux en cours, s’inscrivant dans la continuité d’entreprises précédentes, les auteurs montrent qu’une formalisation des données qui intègre les conditions de leur production et un lien aux appareils documentaires, qui n’est possible que grâce à une collaboration effective avec des praticiens d’autres disciplines, enrichit l’interprétation des données historiques tout en produisant des effets de connaissances quant à leur nature et en donnant naissance à des questions fécondes pour les informaticiens, relatives à la prise en compte de la qualité des données.
Published: 2023
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24. Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021

Author: Woudenberg, Tom, Pinaud, Laurie, Garcia, Laura, Tondeur, Laura, Pelleau, Stephane, de Thoisy, Alix, Donnadieu, Françoise, Backovic, Marija, Attia, Mikaël, Hozé, Nathanaël, Duru, Cécile, Koffi, Aymar Davy, Castelain, Sandrine, Ungeheuer, Marie-Noelle, Fernandes Pellerin, Sandrine, Planas, Delphine, Bruel, Timothée, Cauchemez, Simon, Schwartz, Olivier, Fontanet, Arnaud, White, Michael, Epidémiologie et Analyse des Maladies Infectieuses - Infectious Disease Epidemiology and Analytics, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Hôpital de Crépy-en-Valois, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Institut Pasteur [Paris] (IP), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Virus et Immunité - Virus and immunity (CNRS-UMR3569), This work was supported by the Fondation pour la Recherche Médicale (CorPopImm to MW), and the French Government's Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' (Investissement d'Avenir grant n°ANR-10-LABX-62-IBEID), and INCEPTION programs (Investissement d’Avenir grant ANR-16-CONV-0005), and 'URGENCE COVID-19' fundraising campaign of Institut Pasteur (TooLab project awarded to M.B.). The COVID-Oise cohort is funded by 'Alliance Tous Unis contre le virus' Institut Pasteur, AP-HP and Fondation de France., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), and ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016)
Subjects: seroprevalence, SARS-CoV-2, humoral immunity, sero-epidemiology, viral immunity, COVID-19, antibodies, protection, neutralising antibodies, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; BackgroundThe risk of SARS-CoV-2 (re-)infection remains present given waning of vaccine-induced and infection-acquired immunity, and ongoing circulation of new variants.AimTo develop a method that predicts virus neutralisation and disease protection based on variant-specific antibody measurements to SARS-CoV-2 antigens.MethodsTo correlate antibody and neutralisation titres, we collected 304 serum samples from individuals with either vaccine-induced or infection-acquired SARS-CoV-2 immunity. Using the association between antibody and neutralisation titres, we developed a prediction model for SARS-CoV-2-specific neutralisation titres. From predicted neutralising titres, we inferred protection estimates to symptomatic and severe COVID-19 using previously described relationships between neutralisation titres and protection estimates. We estimated population immunity in a French longitudinal cohort of 905 individuals followed from April 2020 to November 2021.ResultsWe demonstrated a strong correlation between anti-SARS-CoV-2 antibodies measured using a low cost high-throughput assay and antibody response capacity to neutralise live virus. Participants with a single vaccination or immunity caused by infection were especially vulnerable to symptomatic or severe COVID-19. While the median reduced risk of COVID-19 from Delta variant infection in participants with three vaccinations was 96% (IQR: 94–98), median reduced risk among participants with infection-acquired immunity was only 42% (IQR: 22–66).ConclusionOur results are consistent with data from vaccine effectiveness studies, indicating the robustness of our approach. Our multiplex serological assay can be readily adapted to study new variants and provides a framework for development of an assay that would include protection estimates.
Published: 2023
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25. Excessive workload and insufficient night-shift remuneration are key elements of dissatisfaction at work for French neonatologists

Author: Zana-Taïeb, Elodie, Kermorvant-Duchemin, Elsa, Beuchée, Alain, Patkai, Juliana, Rozé, Jean-Christophe, Torchin, Heloise, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Necker - Enfants Malades [AP-HP], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)
Subjects: burnout, quality of life, well-being, [SDV.IB]Life Sciences [q-bio]/Bioengineering, neonatologists, workload
Abstract: International audience; AIM: Neonatologists are exposed to ethical issues and unplanned emergencies that require 24-h in-house coverage. These elements may affect quality of life at work, which we surveyed. METHODS: This was a self-administered, voluntary and anonymous cross-sectional survey of French neonatologists. An online questionnaire was sent to members of the French Society of Neonatology from June to October 2022. RESULTS: Of approximately 1500 possible responses, 721 were analysed, with a response rate of 48%. Respondents were mostly women (77%), aged 35-50 years (50%), and hospital practitioners (63%). Reported weekly working time was over 50 h for 80%. Among the 650 neonatologists with on-call duty, 47% worked ≥5 shifts per month. For 80% of practitioners, on-call duty was perceived to have a negative impact on personal life; 49% indicated having sleep disorders. The mean satisfaction score at work was 5.7 ± 1.7 on a scale of 0-10. The main reasons for dissatisfaction were excessive working hours and insufficient remuneration for on-call duty. CONCLUSION: This first evaluation of the quality of life at work of French neonatologists showed high workload. The working conditions and specificities of NICU activity may have significant consequences for their mental health.
Published: 2023
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26. Collateral impacts of pandemic COVID-19 drive the nosocomial spread of antibiotic resistance: A modelling study

Author: Smith, David, Shirreff, George, Temime, Laura, Opatowski, Lulla, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), University of Oxford, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité), Canadian Institutes of Health Research (Doctoral Foreign Study Award #164263 to D.R.M.S.)MODCOV project from the Fondation de France as part of the alliance framework 'Tous unis contre le virus' (#106059)Université Paris-Saclay (AAP Covid-19 2020), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), and ANR-17-CE36-0008,SPHINx,Diffusion de pathogènes au sein des réseaux de soins : une étude de modélisation(2017)
Subjects: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract: International audience; Background: Circulation of multidrug-resistant bacteria (MRB) in healthcare facilities is a major public health problem. These settings have been greatly impacted by the Coronavirus Disease 2019 (COVID-19) pandemic, notably due to surges in COVID-19 caseloads and the implementation of infection control measures. We sought to evaluate how such collateral impacts of COVID-19 impacted the nosocomial spread of MRB in an early pandemic context.Methods and findings: We developed a mathematical model in which Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and MRB cocirculate among patients and staff in a theoretical hospital population. Responses to COVID-19 were captured mechanistically via a range of parameters that reflect impacts of SARS-CoV-2 outbreaks on factors relevant for pathogen transmission. COVID-19 responses include both "policy responses" willingly enacted to limit SARS-CoV-2 transmission (e.g., universal masking, patient lockdown, and reinforced hand hygiene) and "caseload responses" unwillingly resulting from surges in COVID-19 caseloads (e.g., abandonment of antibiotic stewardship, disorganization of infection control programmes, and extended length of stay for COVID-19 patients). We conducted 2 main sets of model simulations, in which we quantified impacts of SARS-CoV-2 outbreaks on MRB colonization incidence and antibiotic resistance rates (the share of colonization due to antibiotic-resistant versus antibiotic-sensitive strains). The first set of simulations represents diverse MRB and nosocomial environments, accounting for high levels of heterogeneity across bacterial parameters (e.g., rates of transmission, antibiotic sensitivity, and colonization prevalence among newly admitted patients) and hospital parameters (e.g., rates of interindividual contact, antibiotic exposure, and patient admission/discharge). On average, COVID-19 control policies coincided with MRB prevention, including 28.2% [95% uncertainty interval: 2.5%, 60.2%] fewer incident cases of patient MRB colonization. Conversely, surges in COVID-19 caseloads favoured MRB transmission, resulting in a 13.8% [-3.5%, 77.0%] increase in colonization incidence and a 10.4% [0.2%, 46.9%] increase in antibiotic resistance rates in the absence of concomitant COVID-19 control policies. When COVID-19 policy responses and caseload responses were combined, MRB colonization incidence decreased by 24.2% [-7.8%, 59.3%], while resistance rates increased by 2.9% [-5.4%, 23.2%]. Impacts of COVID-19 responses varied across patients and staff and their respective routes of pathogen acquisition. The second set of simulations was tailored to specific hospital wards and nosocomial bacteria (methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase producing Escherichia coli). Consequences of nosocomial SARS-CoV-2 outbreaks were found to be highly context specific, with impacts depending on the specific ward and bacteria evaluated. In particular, SARS-CoV-2 outbreaks significantly impacted patient MRB colonization only in settings with high underlying risk of bacterial transmission. Yet across settings and species, antibiotic resistance burden was reduced in facilities with timelier implementation of effective COVID-19 control policies.Conclusions: Our model suggests that surges in nosocomial SARS-CoV-2 transmission generate selection for the spread of antibiotic-resistant bacteria. Timely implementation of efficient COVID-19 control measures thus has 2-fold benefits, preventing the transmission of both SARS-CoV-2 and MRB, and highlighting antibiotic resistance control as a collateral benefit of pandemic preparedness.
Published: 2023
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27. Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Author: Thomas Schmitz, Muriel Doret-Dion, Loic Sentilhes, Olivier Parant, Olivier Claris, Laurent Renesme, Julie Abbal, Aude Girault, Héloïse Torchin, Marie Houllier, Nolwenn Le Saché, Alexandre J Vivanti, Daniele De Luca, Norbert Winer, Cyril Flamant, Claire Thuillier, Pascal Boileau, Julie Blanc, Véronique Brevaut, Pierre-Emmanuel Bouet, Géraldine Gascoin, Gaël Beucher, Valérie Datin-Dorriere, Stéphane Bounan, Pascal Bolot, Christophe Poncelet, Corinne Alberti, Moreno Ursino, Camille Aupiais, Olivier Baud, Philippe Boize, Charles Garabédian, Florence Flamein, Maela Le Lous, Alain Beuchée, Jean Gondry, Pierre Tourneux, Perrine Coste-Mazeau, Antoine Bedu, Denis Gallot, Karen Coste, Céline Chauleur, Hugues Patural, Gilles Kayem, Delphine Mitanchez, Hélène Heckenroth, Farid Boubred, Jeanne Sibiude, Luc Desfrère, Caroline Bohec, Thierry Mansir, Antoine Koch, Pierre Kuhn, Nadia Tillouche, Fabrice Lapeyre, Franck Perrotin, Géraldine Favrais, Edouard Lecarpentier, Xaxier Durrmeyer, Véronique Equy, Thierry Debillon, Luc Rigonnot, Stéphanie Lefoulgoc, Claudia Brie, Anne-Sophie Pagès, Romy Rayssiguier, Gilles Cambonie, Corinne Cudeville, Doriane Madeleneau, Olivier Morel, Jean-Michel Hascoet, Vincent Letouzey, Massimo Di Maio, Laurent J. Salomon, Alexandre Lapillonne, Hôpital Robert Debré, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), AP-HP - Hôpital Antoine Béclère [Clamart], Service de Pédiatrie et Réanimations néonatales [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), CHI Poissy-Saint-Germain, Physiologie et physiopathologie endocriniennes (PHYSENDO), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier René Dubos [Pontoise], Hôpital Robert Debré Paris, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Centre d'Investigation Clinique 1426 (CIC 1426), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Subjects: Respiratory Distress Syndrome, Newborn, Double-Blind Method, Pregnancy, [SDV]Life Sciences [q-bio], Infant, Newborn, Humans, Premature Birth, Female, Infant, Premature, Diseases, General Medicine, Betamethasone
Abstract: International audience; BackgroundAntenatal betamethasone is recommended before preterm delivery to accelerate fetal lung maturation. However, reports of growth and neurodevelopmental dose-related side-effects suggest that the current dose (12 mg plus 12 mg, 24 h apart) might be too high. We therefore investigated whether a half dose would be non-inferior to the current full dose for preventing respiratory distress syndrome.MethodsWe designed a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial in 37 level 3 referral perinatal centres in France. Eligible participants were pregnant women aged 18 years or older with a singleton fetus at risk of preterm delivery and already treated with the first injection of antenatal betamethasone (11·4 mg) before 32 weeks’ gestation. We used a computer-generated code producing permuted blocks of varying sizes to randomly assign (1:1) women to receive either a placebo (half-dose group) or a second 11·4 mg betamethasone injection (full-dose group) 24 h later. Randomisation was stratified by gestational age (before or after 28 weeks). Participants, clinicians, and study staff were masked to the treatment allocation. The primary outcome was the need for exogenous intratracheal surfactant within 48 h after birth. Non-inferiority would be shown if the higher limit of the 95% CI for the between-group difference between the half-dose and full-dose groups in the primary endpoint was less than 4 percentage points (corresponding to a maximum relative risk of 1·20). Four interim analyses monitoring the primary and the secondary safety outcomes were done during the study period, using a sequential data analysis method that provided futility and non-inferiority stopping rules and checked for type I and II errors. Interim analyses were done in the intention-to-treat population. This trial was registered with ClinicalTrials.gov, NCT02897076.FindingsBetween Jan 2, 2017, and Oct 9, 2019, 3244 women were randomly assigned to the half-dose (n=1620 [49·9%]) or the full-dose group (n=1624 [50·1%]); 48 women withdrew consent, 30 fetuses were stillborn, 16 neonates were lost to follow-up, and 9 neonates died before evaluation, so that 3141 neonates remained for analysis. In the intention-to-treat analysis, the primary outcome occurred in 313 (20·0%) of 1567 neonates in the half-dose group and 276 (17·5%) of 1574 neonates in the full-dose group (risk difference 2·4%, 95% CI –0·3 to 5·2); thus non-inferiority was not shown. The per-protocol analysis also did not show non-inferiority (risk difference 2·2%, 95% CI –0·6 to 5·1). No between-group differences appeared in the rates of neonatal death, grade 3–4 intraventricular haemorrhage, stage ≥2 necrotising enterocolitis, severe retinopathy of prematurity, or bronchopulmonary dysplasia.InterpretationBecause non-inferiority of the half-dose compared with the full-dose regimen was not shown, our results do not support practice changes towards antenatal betamethasone dose reduction.
Published: 2022
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28. Epidemiological Evidence of Nosocomial and Zoonotic Transmission of Human T-Cell Leukemia Virus-1 in a Large Survey in a Rural Population of Central Africa

Author: Jill-Léa Ramassamy, Chanceline Bilounga Ndongo, Patrick Nnuka, Maëlle Antunes, Margot Le Mener, Edouard Betsem a Betsem, Richard Njouom, Olivier Cassar, Arnaud Fontanet, Antoine Gessain, Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Ministère de la Santé Publique [Yaoundé, Cameroun], Université de Douala, Université de Yaoundé I, Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), This work was supported by the European Union as part of the EboSursy project (grant number FOOD/2016/379-660 to J. L. R.), and the Institut Pasteur, France and the Centre National de la Recherche Scientifique, UMR 3569, through the Investissement d’Avenir as part of a Laboratoire d’Excellence French research program, Integrative Biology of Emerging Infectious Diseases (grant number ANR10-LBX- 62 IBEID to A. G.). Funding to pay the Open Access publication charges for this article was provided by the European Union., and ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)
Subjects: Infectious Diseases, HTLV-1, [SDV]Life Sciences [q-bio], Immunology and Allergy, Cameroon HTLV-1 central Africa cross-sectional survey epidemiology nosocomial zoonoses, epidemiology, nosocomial, Cameroon, central Africa, cross-sectional survey, zoonoses
Abstract: Background Central Africa is one of the largest areas of high endemicity for human T-cell leukemia virus-1 (HTLV-1). However, no preventive measures are yet implemented to reduce its transmission, which can be sexual, from mother-to-child, or through contaminated blood products. Rare zoonotic transmissions from nonhuman primates (NHPs) have also been reported in this region. Here we investigated the HTLV-1 prevalence and associated risk factors in a rural population in Cameroon. Methods From 2019 to 2021, we performed a cross-sectional survey in the eastern region of Cameroon. HTLV-1 infection was first screened by ELISA, then tested by western blot and envelope gene targeted polymerase chain reaction. Risk factors associated with HTLV-1 infection were identified by logistic regression in univariable and multivariable analyses. Results Among 3400 participants, HTLV-1 prevalence was 1.1% (95% confidence interval [CI], .7–1.5). Factors independently associated with HTLV-1 infection were Pygmy ethnicity (adjusted odd ratio [aOR], 2.9; 95% CI, 1.3–6.2), history of surgery (aOR, 6.3; 95% CI, 2.2–17.8), and NHP bite (aOR, 6.6; 95% CI, 2.2–19.8). Conclusions These results suggest both iatrogenic and zoonotic transmission of HTLV-1 in Cameroon. Further studies are needed to assess the risk of nosocomial transmission of HTLV-1, to guide public health authorities in implementing preventive measures to control HTLV-1 transmission.
Published: 2022
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29. Meta‐analysis: risk of hepatitis C virus infection associated with hospital‐based invasive procedures

Author: Paul Henriot, Mathieu Castry, Liem Binh Luong Nguyen, Yusuke Shimakawa, Kévin Jean, Laura Temime, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Agence Nationale de Recherches sur le Sida et les Hepatites Virales, Grant/Award Number: 12320 B115
Subjects: MESH: Humans, Hepatology, [SDV]Life Sciences [q-bio], Gastroenterology, Hepacivirus, MESH: Hospitals, Hepatitis C, Hospitals, MESH: Odds Ratio, Risk Factors, MESH: Risk Factors, Odds Ratio, Prevalence, Humans, MESH: Hepacivirus, Pharmacology (medical), MESH: Prevalence
Abstract: International audience; BackgroundHealthcare settings, where invasive procedures are frequently performed, may play an important role in the transmission dynamics of blood-borne pathogens when compliance with infection control precautions is suboptimal.AimsTo understand and quantify the role of hospital-based invasive procedures on hepatitis C virus (HCV) transmission.MethodsWe conducted a systematic review and meta-analysis to identify recent studies reporting association measures of HCV infection risk that are linked to iatrogenic procedures. Based on expert opinion, invasive procedures were categorised into 10 groups for which pooled measures were calculated. Finally, the relationship between pooled measures and the country-level HCV prevalence or the Healthcare Access and Quality (HAQ) index was assessed by meta-regression.ResultsWe included 71 studies in the analysis. The most frequently evaluated procedures were blood transfusion (66 measures) and surgery (43 measures). The pooled odds ratio (OR) of HCV infection varied widely, ranging from 1.46 (95% confidence interval: 1.14–1.88) for dental procedures to 3.22 (1.7–6.11) for transplantation. The OR for blood transfusion was higher for transfusions performed before 1998 (3.77, 2.42–5.88) than for those without a specified/recent date (2.20, 1.77–2.75). In procedure-specific analyses, the HCV infection risk was significantly negatively associated with the HAQ for endoscopy and positively associated with HCV prevalence for endoscopy and surgery.ConclusionsVarious invasive procedures were significantly associated with HCV infection. Our results provide a ranking of procedures in terms of HCV risk that may be used for prioritisation of infection control interventions, especially in high HCV prevalence settings.
Published: 2022
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30. Electrical Railway Dynamical Versus Static Models for Infrastructure Planning and Operation

Author: Alain Bouscayrol, Islam El-Sayed, Clement Mayet, Philippe Delarue, Pablo Arboleya, Bassam Mohamed, University of Oviedo, Systèmes et Applications des Technologies de l'Information et de l'Energie (SATIE), École normale supérieure - Rennes (ENS Rennes)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Gustave Eiffel-CY Cergy Paris Université (CY), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), University of Lille, Laboratoire d’Électrotechnique et d’Électronique de Puissance - ULR 2697 (L2EP), Centrale Lille-Université de Lille-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-JUNIA (JUNIA), and Université catholique de Lille (UCL)-Université catholique de Lille (UCL)
Subjects: Computer science, Mechanical Engineering, [SPI.NRJ]Engineering Sciences [physics]/Electric power, Control engineering, Energy consumption, Computer Science Applications, law.invention, Power (physics), [SPI]Engineering Sciences [physics], Traction power network, law, Electrical network, Automotive Engineering, Cartesian coordinate system, Train, Energy supply, Power-flow study, ComputingMilieux_MISCELLANEOUS
Abstract: Simulation tools are essential to design the infrastructure and plan the trains operations of electrical railway systems. Traditionally, the train model (that estimates the electrical, mechanical and kinematical behaviors of the vehicles) and electrical network model (that estimates the electrical behavior of the energy supply network) are developed separately. Then, they are simulated together to estimate the interactions between both subsystems. The paper objective is to compare different models to highlight the impacts on the interactions between the vehicles and the railway electrical network, which are crucial to have accurate estimations of the system behavior. For this purpose, a new dynamical model, which is based on a systemic approach and a causality analysis, is compared to a conventional static model, which is based on a cartesian approach and a power flow analysis. The dynamical model is accurate and has been experimentally validated but requires a long computational time. The static model is fast to compute and give a good estimation of the energy consumption for conventional railway systems. However, it is not always able to estimate the power flows within the DC network, and especially when all traction power substations are blocked.
Published: 2022
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31. Adaptive Deadlock Control for a Class of Petri Nets With Unreliable Resources

Author: Zhiwu Li, Kamel Barkaoui, Gaiyun Liu, Ziliang Zhang, Xidian University, CEDRIC. Systèmes sûrs (CEDRIC - SYS), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and Macau University of Science and Technology (MUST)
Subjects: Class (computer programming), Theoretical computer science, Computer science, Deadlock, Petri net, Computer Science Applications, Human-Computer Interaction, [SPI]Engineering Sciences [physics], Control and Systems Engineering, [INFO]Computer Science [cs], Electrical and Electronic Engineering, Control (linguistics), ComputingMilieux_MISCELLANEOUS, Software
Abstract: International audience
Published: 2022
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32. Risk perceptions and health care use in the era of the COVID-19 pandemic in adults treated for childhood cancer

Author: Asmaa Janah, Charlotte Demoor-Goldschmidt, Florent De Vathaire, Nicolas Bougas, Jacqueline Clavel, Claire Poulalhon, Brigitte Lacour, Vincent Souchard, Angela Jackson, Leonie Casagranda, Claire Berger, Rodrigue Allodji, Nadia Haddy, Chiraz El Fayech, Brice Fresneau, Agnès Dumas, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Institut Gustave Roussy (IGR), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Subjects: Adult, Risk perception, Pandemic, Chronic health conditions, [SDV]Life Sciences [q-bio], COVID-19, Health care use, Childhood cancer survivors, Teleconsultation use, Forgoing care, Cancer Survivors, Oncology, Neoplasms, Humans, Child, Delivery of Health Care, Pandemics
Abstract: International audience; Purpose: During the COVID-19 pandemic, childhood cancer survivors (CCS) may have felt more at risk of having severe consequences of COVID-19 and therefore may have been more likely to defer their health care use. We aimed to assess the risk perceptions of CCS related to COVID-19 (perceived infection risk, perceived risk of experiencing a severe illness in the event of infection), and their forgoing of health care during the year 2020.Methods: In December 2020, we interviewed through an online self-report questionnaire 580 5-year CCS participating in the French Childhood Cancer Survivor Study (FCCSS) cohort. Combining clinical and patient-reported outcomes, we studied predictors of perceived risks related to COVID-19 and forgoing health care.Results: Overall, 60% of respondents stated that COVID-19 could have severe consequences for their health if infected. Survivors with a cardiovascular disease and those who felt more at risk of being infected were more likely to think that COVID-19 could have severe health consequences for them. Moreover, 30% of respondents seeking care declared they had forgone at least one medical appointment in 2020. Forgoing medical appointments was more common among CCS who reported a deterioration in their financial situation in 2020 and those who felt more at risk of being infected.Conclusions: This study shows that a considerable proportion of survivors had forgone medical appointments because of the pandemic; forgoing care was more frequent among the most socioeconomically disadvantaged survivors.Implications for cancer survivors: This study presents data hitherto absent in the literature and suggests the need to develop telehealth to ensure appropriate long-term follow-up of CCS.
Published: 2022
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33. Antenna Radiation Efficiency Estimation From Backscattering Measurement Performed Within Reverberation Chambers

Author: Wafa Krouka, Francois Sarrazin, Julien de Rosny, Adnane Labdouni, Elodie Richalot, Electronique, Systèmes de communication et Microsystèmes (ESYCOM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: contactless measurement, backscattering measurement, FOS: Physical sciences, quality factor, 020206 networking & telecommunications, Applied Physics (physics.app-ph), Physics - Applied Physics, 02 engineering and technology, Condensed Matter Physics, reverberation chamber, Atomic and Molecular Physics, and Optics, [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, Antenna radiation efficiency, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering
Abstract: This paper presents a contactless measurement method for antenna radiation efficiency estimation within reverberation chambers (RCs). This method does not require to connect any analyzer to the antenna under test (AUT). The AUT radiation efficiency is obtained from the differential measurement of the RC composite $Q$-factor estimated for two AUT load conditions, namely an open circuit and a \SI[detect-weight]{50}{\ohm} load. Remotely-controlled RF switches are used in order to keep the setup identical for both measurements. The method is experimentally validated in two RCs of different volumes (1~m$^3$ and 19~m$^3$) with a wideband patch antenna in the 1.8~GHz to 2.8~GHz frequency range. The estimated efficiency is found to be in very good agreement with the one obtained through a conventional invasive RC measurement technique. This new method is suitable for miniature and buried antenna characterization without access to its port.
Published: 2022
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34. How do prosocial motivation and performance‐related pay interact in the workplace context? Evidence from the non‐profit sector

Author: Lanfranchi, Joseph, Narcy, Mathieu, Centre d'études de l'emploi et du travail (CEET), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)-Ministère du Travail, de l'Emploi et de la Santé, Laboratoire d'économie et de management de Nantes Atlantique (LEMNA), Nantes Université - Institut d'Administration des Entreprises - Nantes (Nantes Univ - IAE Nantes), Nantes Université - pôle Sociétés, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sociétés, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-FR 3473 Institut universitaire Mer et Littoral (IUML), Le Mans Université (UM)-Université d'Angers (UA)-Université de Bretagne Sud (UBS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Le Mans Université (UM)-Université d'Angers (UA)-Université de Bretagne Sud (UBS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université - École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ), Travail, Emploi et Politiques Publiques (TEPP), Université Paris-Est Marne-la-Vallée (UPEM)-Centre National de la Recherche Scientifique (CNRS), LIRSA. Centre de recherche en comptabilité (LIRSA-CRC), Laboratoire interdisciplinaire de recherche en sciences de l'action (LIRSA), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Equipe de Recherche sur l’Utilisation des Données Individuelles en lien avec la Théorie Economique (ERUDITE), and Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Gustave Eiffel
Subjects: Economics and Econometrics, [QFIN]Quantitative Finance [q-fin], Arts and Humanities (miscellaneous)
Abstract: International audience
Published: 2022
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35. Extended Reality Guidelines for Supporting Autism Interventions Based on Stakeholders’ Needs

Author: Valentin Bauer, Tifanie Bouchara, Patrick Bourdot, Virtual & augmented ENvIronments for Simulation & Experiments (VENISE ), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Interaction avec l'Humain (IaH), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), CEDRIC - Interactivité pour Lire et Jouer (CEDRIC - ILJ), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)
Subjects: Extended reality, Autism spectrum disorder, Interviews, Design guidelines, Mediation, Multi-sensorimotor, Developmental and Educational Psychology, [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR]
Abstract: International audience; While Extended Reality (XR) autism research, ranging from Augmented to Virtual Reality, focuses on socioemotional abilities and autistic children requiring low support, common interventions address the entire spectrum and focus on other abilities, including perceptual abilities. Based on these observations, this paper first addresses common practitioners' interventions, and then suggests XR use cases and guidelines to better support them. To do so, 34 interviews were conducted with stakeholders, mainly including practitioners, and then analyzed. Emerging XR use cases were compared with the findings from two former systematic literature reviews, and emerging design guidelines were compared with the findings from a literature survey that we conducted. Findings suggest that collaborative XR sensory-based and mediation approaches could benefit the entire spectrum.
Published: 2022
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36. A [K, KL] Sector-Based Hands-Off Control With Quantization Parameter Mismatch

Author: Shyam Kamal, Sharat Chandra Mahto, Ankit Sachan, Vijay Kumar Singh, Thach Ngoc Dinh, Hiroshima University, Indian Institute of Technology [BHU Varanasi] (IIT BHU), CEDRIC. Traitement du signal et architectures électroniques (CEDRIC - LAETITIA), Centre d'études et de recherche en informatique et communications (CEDRIC), and Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)
Subjects: Quantization (signal processing), 020208 electrical & electronic engineering, 0202 electrical engineering, electronic engineering, information engineering, 02 engineering and technology, Electrical and Electronic Engineering, Control (linguistics), Algorithm, ComputingMilieux_MISCELLANEOUS, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Mathematics
Abstract: International audience
Published: 2022
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37. Housing conditions and changes in professional activity during lockdown and the risk of prevalent and incident depression: Findings from the CONSTANCES cohort

Author: Clément Gouraud, Emmanuel Wiernik, Joane Matta, Maria Melchior, Guillaume Airagnes, Charles Ouazana-Vedrines, Olivier Robineau, Fabrice Carrat, Gianluca Severi, Alexis Descatha, Mathilde Touvier, Marcel Goldberg, Marie Zins, Cédric Lemogne, Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Sorbonne Université (SU), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Santé Publique : épidémiologie et qualité des soins (EA 2694), Faculté de Médecine Henri Warembourg - Université de Lille-Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University [Hempstead], Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de recherche et d'études en sciences sociales (CRESS) (EA 1334 - UMB), The CONSTANCES cohort is supported by the Caisse Nationale d'Assurance Maladie des travailleurs salaries-CNAMTS. CONSTANCES is accredited as a 'National Infrastructure for Biology and health' by the governmental Investissements d'avenir program and was funded by the Agence Nationale de la Recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. The funders did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.CL and CG are supported by a grant from 'la Fondation de l'Assistance Publique - Hôpitaux de Paris'., and ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011)
Subjects: Psychiatry and Mental health, Clinical Psychology, Distance working, Depression, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Lockdown, Cohort study, COVID
Abstract: Background: Material conditions of lockdown and changes in regular functioning may have played a role on depressive manifestations. We aimed to examine the association between housing conditions and changes in professional activity and depression during the first COVID-19 outbreak in France.Method: Participants of the CONSTANCES cohort were followed online. A first questionnaire covered the lockdown period (assessing housing conditions and changes in professional activity), and a second the post-lockdown period (assessing depression using the Center of Epidemiologic Studies Depression-Scale (CES-D)). Incident depression was also estimated (with a previous CES-D measure). Logistic regression models were applied.Results: 22,042 participants (median age 46 years, 53.2 % women) were included and 20,534 had a previous CES-D measure. Depression was associated with female gender, lower household income and past history of depression. A negative gradient between the number of rooms and the likelihood of depression was consistently observed (OR = 1.55 95 % [1.19-2.00] for one room, OR = 0.76 [0.65-0.88] for seven rooms), while a U-shape relationship was observed with the number of people living together (OR = 1.62 [1.42-1.84] for living alone, OR = 1.44 [1.07-1.92] for six persons). These associations were also observed with incident depression. Changes in professional activity were associated with depression (Started distance working (OR = 1.33 [1.17-1.50]). Starting distance working was also associated with incident depression (OR = 1.27 [1.08-1.48]).Limitation: A cross-sectional design was used.Conclusion: The consequences of lockdown on depression may vary depending on living conditions and changes in professional activity, including distance working. These results could help to better identify vulnerable people to promote mental health.
Published: 2023
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38. Climate change and vector-borne diseases: a multi-omics approach of temperature-induced changes in the mosquito

Author: Bellone, Rachel, Lechat, Pierre, Mousson, Laurence, Gilbart, Valentine, Piorkowski, Géraldine, Bohers, Chloé, Merits, Andres, Kornobis, Etienne, Reveillaud, Julie, Paupy, Christophe, Vazeille, Marie, Martinet, Jean-Philippe, Madec, Yoann, de Lamballerie, Xavier, Dauga, Catherine, Failloux, Anna-Bella, Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Collège Doctoral, Sorbonne Université (SU), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Tartu, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), This work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731060 (Infravec2, Research Infrastructures for the control of vector-borne diseases), the Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant n°ANR-10-LABX-62-IBEID) and the European Union’s Horizon 2020 research and innovation programme under ZIKAlliance grant agreement No 734548., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), and European Project: 734548,ZIKAlliance(2016)
Subjects: chikungunya, [SDV]Life Sciences [q-bio], Temperature, General Medicine, Aedes albopictus
Abstract: Background Climate change and globalization contribute to the expansion of mosquito vectors and their associated pathogens. Long spared, temperate regions have had to deal with the emergence of arboviruses traditionally confined to tropical regions. Chikungunya virus (CHIKV) was reported for the first time in Europe in 2007, causing a localized outbreak in Italy, which then recurred repeatedly over the years in other European localities. This raises the question of climate effects, particularly temperature, on the dynamics of vector-borne viruses. The objective of this study is to improve the understanding of the molecular mechanisms set up in the vector in response to temperature. Methods We combine three complementary approaches by examining Aedes albopictus mosquito gene expression (transcriptomics), bacterial flora (metagenomics) and CHIKV evolutionary dynamics (genomics) induced by viral infection and temperature changes. Results We show that temperature alters profoundly mosquito gene expression, bacterial microbiome and viral population diversity. We observe that (i) CHIKV infection upregulated most genes (mainly in immune and stress-related pathways) at 20°C but not at 28°C, (ii) CHIKV infection significantly increased the abundance of Enterobacteriaceae Serratia marcescens at 28°C and (iii) CHIKV evolutionary dynamics were different according to temperature. Conclusion The substantial changes detected in the vectorial system (the vector and its bacterial microbiota, and the arbovirus) lead to temperature-specific adjustments to reach the ultimate goal of arbovirus transmission; at 20°C and 28°C, the Asian tiger mosquito Ae. albopictus was able to transmit CHIKV at the same efficiency. Therefore, CHIKV is likely to continue its expansion in the northern regions and could become a public health problem in more countries than those already affected in Europe.
Published: 2023
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39. Changes in physical activity patterns from adolescence to young adulthood: the BELINDA study

Author: Vanhelst, Jérémy, Béghin, Laurent, Drumez, Elodie, Labreuche, Julien, Polito, Angela, de Ruyter, Thaïs, Censi, Laura, Ferrari, Marika, Miguel-Berges, Maria Luisa, Michels, Nathalie, de Henauw, Stefaan, Moreno, Luis, Gottrand, Frédéric, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301 (CIC Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Department of Public Health and Primary Care, Universiteit Gent = Ghent University (UGENT), Growth, Exercise, Nutrition and Development, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Instituto Agroalimentario de Aragón (IA2), University of Zaragoza - Universidad de Zaragoza [Zaragoza]-Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), and Instituto de Investigación Sanitaria de Aragón [Zaragoza] (IIS Aragón)
Subjects: [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Physical activity, Health, Tracking, [SDV]Life Sciences [q-bio], Pediatrics, Perinatology and Child Health
Abstract: International audience; Physical activity (PA) is recognized as a marker of health. The aim was to investigate PA differences from adolescence to young adulthood. European adolescents included in the HELENA study were invited to participate in a follow-up study, 10 years later. The present study included 141 adults (25.0 ± 1.4 years) for whom valid accelerometer data were available in adolescence and adulthood. Changes in PA by sex, weight and maternal education level were explored with interactions. Time spent in sedentary activity, light PA (LPA) and moderate PA (MPA) increased by 39.1, 59.6 and 6.6 min/day, respectively, whereas the time spent in vigorous PA (VPA) decreased by 11.3 min/day compared with adolescent VPA (p
Published: 2023
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40. Thyroid dysfunction during gestation and gestational diabetes mellitus: a complex relationship

Author: S. Pinto, L. Croce, L. Carlier, E. Cosson, M. Rotondi, Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'endocrinologie, diabétologie, nutrition, Università degli Studi di Pavia = University of Pavia (UNIPV), Laboratory for Endocrine Disruptors, Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), National Biodiversity Future Center (NBFC), Service d'endocrinologie diabétologie, nutrition (Hôpital Jean Verdier), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Nord, Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF), Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Department of Internal Medicine and Therapeutics
Subjects: Thyroid, Thyroid Pregnancy Hypothyroidism Gestational diabetes mellitus, Endocrinology, Hypothyroidism, Pregnancy, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Gestational diabetes mellitus, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Purpose Gestational diabetes mellitus (GDM) and thyroid dysfunction during gestation (GTD) are the two most prevalent endocrinopathies during pregnancy. The aim of the present review is to provide an overview of the peculiar aspects of GDM and GTD, to highlight the potential interactions and clinical consequences of these two frequent clinical conditions. Methods A literature review regarding GDM and GTD was carried out with particular interest on meta-analyses and human studies dealing with the (i) shared risk factors between GDM and GTD, (ii) the epidemiological link between GTD and GDM, (iii) physiopathologic link between GTD and GDM, (iv) clinical consequences of GDM and GTD, and (v) post-partum implications of GDM and GTD. Results The association between GDM and GTD is common and may be explained by the insulin-resistance state due to maternal GTD, to alterations in the placentation process or to the many shared risk factors. Discrepant results of epidemiologic studies can be explained, at least in part, by the changes in diagnostic criteria and screening strategies throughout the years for both conditions. GDM and GTD impact pregnancy outcome and have post-partum long-term consequences, but more studies are needed to prove an additional adverse effect. Conclusions Based on the epidemiological and physio-pathological link between GDM and GTD, it could be suggested that a diagnosis of GTD could lead to screen GDM and the other way round.
Published: 2023
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41. Same-sex sexual behaviour and psychological health: CONSTANCES, a population survey in France

Author: Marie-Josèphe Saurel-Cubizolles, Brigitte Lhomond, Mireille Coeuret-Pellicer, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lyon, Triangle : action, discours, pensée politique et économique (TRIANGLE), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Cohortes épidémiologiques en population (CONSTANCES), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité)
Subjects: Health (social science), Health Policy, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Public Health, Environmental and Occupational Health, Sex, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Regular Article, Psychological health, Same-sex partner, Social inequalities
Abstract: International audience; Rationale: Having same-sex partners is linked to poor psychological health and increased risk of suicide attempt. This link seems to be stronger for men than women. However, in France, there have been few studies of population samples, and the size of these studies does not always allow an in-depth analysis of these associations.Methods and results: This study explored these associations by analysing data from a large epidemiological survey conducted in France from 2012 to 2019 that included 84,791 women and 75,530 men. The frequencies and risk ratios of depression, suicide attempts, alcohol dependence and regular cannabis use were calculated regarding two groups: those with only the other sex partners and those with any same sex partners. Risk of alcohol addiction and cannabis use was greatly increased for women who had homosexual relations, even after adjustment for social, demographic and sexual life factors, which was not the case for men. However, risk of depression and suicide attempts was increased for men who had homosexual relations; this was also true for women but to a lesser extent. The estimates remained unchanged after stratifying the population by three distinct social groups defined by education level.Conclusions: The analysis of these differences was possible because of the large sample size of the CONSTANCES survey and its recruitment in the general population. This study helps increase knowledge of the health of sexual minorities. It can help clinicians pay more attention to the potential distress of their patients and can continue to inform policymakers of the effects of discrimination and stigmatisation linked to homosexual behaviour.
Published: 2023
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42. A deep learning model for the diagnosis of sacroiliitis according to Assessment of SpondyloArthritis International Society classification criteria with magnetic resonance imaging

Author: Adrien Bordner, Théodore Aouad, Clementina Lopez Medina, Sisi Yang, Anna Molto, Hugues Talbot, Maxime Dougados, Antoine Feydy, Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Dèpartement de Radiologie, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de vision numérique (CVN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay, Department of Rheumatology, Universidad de Córdoba = University of Córdoba [Córdoba], Université Paris Cité (UPCité), Equipe 4 : ECaMO - Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Dèpartement de Rheumatologie
Subjects: Artificial intelligence, Magnetic resonance imaging, Radiological and Ultrasound Technology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV]Life Sciences [q-bio], Spondyloarthritis, Radiology, Nuclear Medicine and imaging, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Sacroiliac joint, Deep-learning, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: International audience; PurposeThe purpose of this study was to develop and evaluate a deep learning model to detect bone marrow edema (BME) in sacroiliac joints and predict the MRI Assessment of SpondyloArthritis International Society (ASAS) definition of active sacroiliitis in patients with chronic inflammatory back pain.Materials and methodsMRI examinations of patients from the French prospective multicenter DESIR cohort (DEvenir des Spondyloarthropathies Indifférenciées Récentes) were used for training, validation and testing. Patients with inflammatory back pain lasting three months to three years were recruited. Test datasets were from MRI follow-ups at five years and ten years. The model was evaluated using an external test dataset from the ASAS cohort. A neuronal network classifier (mask-RCNN) was trained and evaluated for sacroiliac joints detection and BME classification. Diagnostic capabilities of the model to predict ASAS MRI active sacroiliitis (BME in at least two half-slices) were assessed using Matthews correlation coefficient (MCC), sensitivity, specificity, accuracy and AUC. The gold standard was experts' majority decision.ResultsA total of 256 patients with 362 MRI examinations from the DESIR cohort were included, with 27% meeting the ASAS definition for experts. A total of 178 MRI examinations were used for the training set, 25 for the validation set and 159 for the evaluation set. MCCs for DESIR baseline, 5-years, and 10-years follow-up were 0.90 (n = 53), 0.64 (n = 70), and 0.61 (n = 36), respectively. AUCs for predicting ASAS MRI were 0.98 (95% CI: 0.93–1), 0.90 (95% CI: 0.79–1), and 0.80 (95% CI: 0.62–1), respectively. The ASAS external validation cohort included 47 patients (mean age 36 ± 10 [SD] years; women, 51%) with 19% meeting the ASAS definition. MCC was 0.62, sensitivity 56% (95% CI: 42–70), specificity 100% (95% CI: 100–100) and AUC 0.76 (95% CI: 0.57–0.95).ConclusionThe deep learning model achieves performance close to those of experts for BME detection in sacroiliac joints and determination of active sacroiliitis according to the ASAS definition.
Published: 2023
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43. Peripartum severe acute maternal morbidity in low-risk women: A population-based study

Author: Chantry AA, Peretout P, Chiesa-Dubruille C, Crenn-Hébert C, Vendittelli F, Le Ray C, Deneux-Tharaux C, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Low-risk pregnancy Severe maternal morbidity Postpartum haemorrhage Gestational anaemia Primiparity, Maternity and Midwifery, Obstetrics and Gynecology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Abstract: International audience; Background: Knowledge of severe acute maternal morbidity (SAMM) and its risk factors is constantly growing, but studies have rarely focused on the specific population of low-risk women. Aim: To estimate the prevalence and to identify subgroups at risk of peripartum SAMM in low-risk women Methods: From a population-based cohort-nested case-control study conducted in six French regions, i.e., 182 309 women who gave birth at ≥22 weeks in 119 maternity units, we selected women considered at low risk up to the end of pregnancy before labour according to the NICE guidelines and compared those experiencing peripartum SAMM (during birth and up to 7 days postpartum; n = 489) to a 2% random sample of women without peripartum SAMM from the same units (n = 1800). Risk factors for peripartum SAMM were identified by multivariable logistic regression. Findings: amongst low-risk women, the estimated rate of SAMM was 0.548/100 deliveries (95%CI 0.501-0.599). Severe obstetric haemorrhage was the main cause (83.6% of SAMM cases). Main risk factors for peripartum SAMM were primiparity (aOR 2.4, 95%CI 1.9-3.0), IVF pregnancy (aOR 1.8, 1.0-3.4), thirdtrimester anaemia (aOR 1.7, 1.3-2.3), being born out of Europe or Africa (aOR 1.9, 1.2-3.0). Conclusion: amongst women considered at low risk up to the end of pregnancy before labour, peripartum SAMM is rare but still exists. Knowledge of risk factors of SAMM in this population will inform the discussion on peripartum risks and the most appropriate place of birth for each woman.
Published: 2023
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44. Higher adherence to the EAT-Lancet reference diet is associated with higher nutrient adequacy in the NutriNet-Santé cohort: a cross-sectional study

Author: Florine Berthy, Joséphine Brunin, Benjamin Allès, Anouk Reuzé, Mathilde Touvier, Serge Hercberg, Denis Lairon, Philippe Pointereau, François Mariotti, Julia Baudry, Emmanuelle Kesse-Guyot, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agence de l'Environnement et de la Maîtrise de l'Energie (ADEME), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Association Solagro (Solagro), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), and AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Nutrition and Dietetics, Medicine (miscellaneous), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, food system, sustainable diet, nutritional quality assessment, healthy eating
Abstract: International audience; In 2019, the EAT-Lancet Commission proposed a planetary and healthy reference diet; however, its nutritional quality has been rarely evaluated.Across different adherence levels to the EAT-Lancet reference diet, the following were our objectives:1) describe the food and nutritional intakes of the French population, 2) evaluate the nutrient quality, and 3) investigate the consistency between the French national recommendations and the EAT-Lancet reference diet.This cross-sectional study was conducted among participants of the NutriNet-Santé cohort, and the sample was weighted on the characteristics of the general French population. Adherence to the EAT-Lancet reference diet was estimated using the EAT-Lancet Diet Index (ELD-I). Usual nutrient intakes were obtained using the variance reduction method. We used the estimated average requirements cut-point method to estimate the proportion of participants who meet their respective nutritional requirements. Furthermore, the adequacy of the French food-based dietary recommendations [Programme National Nutrition Santé (PNNS)] according to adherence to the EAT-Lancet reference diet was studied.The weighted sample was composed of 98,465 participants. Except for bioavailable zinc and vitamin B12, we observed a decrease in the nutrient inadequacy prevalence when the adherence to the EAT-Lancet reference diet increased, particularly for vitamin B9 (Q1 = 37.8% compared with Q5 = 5.5%, P < 0.0001) and vitamin C (Q1 = 59.0% compared with Q5 = 10.8 %, P < 0.0001). However, inadequacy prevalence remained high in all ELD-I quintiles, particularly for fiber (95.9%), vitamin B1 (70.8%), iodine (48.4%), and magnesium (76.8%). Higher ELD-I score was associated with higher adherence for most components of the PNNS, except for food groups that are not specifically included in the EAT-Lancet reference diet and are typical of the French diet, including alcohol, processed meat, and salt.In the French context, although issues with the intake of certain nutrients may occur, a diet that remains within the planetary limits as the EAT-Lancet reference diet allows a favorable nutritional quality.
Published: 2023
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45. ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample: the SAPRIS-SERO multi-cohort study

Author: Deschasaux-Tanguy, Mélanie, Szabo de Edelenyi, Fabien, Druesne-Pecollo, Nathalie, Esseddik, Younes, Allègre, Julien, Srour, Bernard, Galan, Pilar, Hercberg, Serge, Severi, Gianluca, Zins, Marie, Wiernik, Emmanuel, de Lamballerie, Xavier, Carrat, Fabrice, Touvier, Mathilde, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Firenze = University of Florence (UniFI), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and SAPRIS-SERO study group: Fabrice Carrat, Pierre-Yves Ancel, Nathalie Bajos, Marie-Aline Charles, Gianluca Severi, Mathilde Touvier, Marie Zins, Sofiane Kab, Adeline Renuy, Stéphane Le Got, Céline Ribet, Mireille Pellicer, Emmanuel Wiernik, Marcel Goldberg, Marie Zins, Fanny Artaud, Pascale Gerbouin-Rérolle, Mélody Enguix, Camille Laplanche, Roselyn Gomes-Rimav, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Gianluca Severi, Fabien Szabo de Edelenyi, Julien Allègre, Nathalie Druesne-Pecollo, Younes Esseddik, Serge Hercberg, Mathilde Touvier, Marie-Aline Charles, Pierre-Yves Ancel, Valérie Benhammou, Anass Ritmi, Laetitia Marchand, Cecile Zaros, Elodie Lordmi, Adriana Candea, Sophie de Visme, Thierry Simeon, Xavier Thierry, Bertrand Geay, Marie-Noelle Dufourg, Karen Milcent, Clovis Lusivika-Nzinga, Gregory Pannetier, Nathanael Lapidus, Isabelle Goderel, Céline Dorival, Jérôme Nicol, Olivier Robineau, Fabrice Carrat, Cindy Lai, Liza Belhadji, Hélène Esperou, Sandrine Couffin-Cadiergues, Jean-Marie Gagliolo, Hélène Blanché, Jean-Marc Sébaoun, Jean-Christophe Beaudoin, Laetitia Gressin, Valérie Morel, Ouissam Ouili, Jean-François Deleuze, Stéphane Priet, Paola Mariela Saba Villarroel, Toscane Fourié, Souand Mohamed Ali, Abdenour Amroun, Morgan Seston, Nazli Ayhan, Boris Pastorino, Xavier de Lamballerie
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience; Abstract ABO blood type has been reported as a potential factor influencing SARS-CoV-2 infection, but so far mostly in studies that involved small samples, selected population and/or used PCR test results. In contrast our study aimed to assess the association between ABO blood types and SARS-CoV-2 infection using seroprevalence data (independent of whether or not individuals had symptoms or sought for testing) in a large population-based sample. Our study included 67,340 French participants to the SAPRIS-SERO multi-cohort project. Anti-SARS-CoV-2 antibodies were detected using ELISA (targeting the proteins spike (S) and nucleocapsid (NP)) and seroneutralisation (SN) tests on dried blood spots collected in May–November 2020. Non-O individuals (and especially types A and AB) were more likely to bear anti SARS-CoV-2 antibodies (ELISA-S, 2964 positive cases: OR non-Ovs.O = 1.09[1.01–1.17], OR Avs.O = 1.08[1.00–1.17]; ELISA-S/ELISA-NP/SN, 678 triple positive cases: OR non-Ovs.O = 1.19 [1.02–1.39], OR Avs.O = 1.19[1.01–1.41], OR ABvs.O = 1.43[1.01–2.03]). Hence, our results provided additional insights into the dynamic of SARS-CoV-2 infection, highlighting a higher susceptibility of infection for individuals of blood types A and AB and a lesser risk for blood type O.
Published: 2023
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46. Sick leave due to COVID-19 during the first pandemic wave in France, 2020

Author: David R M Smith, Sofía Jijón, Ajmal Oodally, George Shirreff, Karim Aït Bouziad, Pearl Anne Ante-Testard, Jonathan Bastard, Hanifa Bouziri, Oumou Salama Daouda, Tom Duchemin, Anne-Sophie Godon-Rensonnet, Paul Henriot, Yasmine Houri, Hélène Neynaud, Anne Perozziello, Frédérique Thonon, Pascal Crépey, William Dab, Kévin Jean, Laura Temime, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris-Saclay, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité), Centre de Recherches sur l'Action Politique en Europe (ARENES), Université de Rennes (UR)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS), Recherche sur les services et le management en santé (RSMS), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Imperial College London, None, and Internationale
Subjects: Theoretical, Epidemiology, Models, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, COVID-19, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Sick Leave, Disease Outbreaks
Abstract: ObjectivesTo quantify the burden of COVID-19-related sick leave during the first pandemic wave in France, accounting for sick leaves due to symptomatic COVID-19 (‘symptomatic sick leaves’) and those due to close contact with COVID-19 cases (‘contact sick leaves’).MethodsWe combined data from a national demographic database, an occupational health survey, a social behaviour survey and a dynamic SARS-CoV-2 transmission model. Sick leave incidence from 1 March 2020 to 31 May 2020 was estimated by summing daily probabilities of symptomatic and contact sick leaves, stratified by age and administrative region.ResultsThere were an estimated 1.70M COVID-19-related sick leaves among France’s 40M working-age adults during the first pandemic wave, including 0.42M due to COVID-19 symptoms and 1.28M due to COVID-19 contacts. There was great geographical variation, with peak daily sick leave incidence ranging from 230 in Corse (Corsica) to 33 000 in Île-de-France (the greater Paris region), and greatest overall burden in regions of north-eastern France. Regional sick leave burden was generally proportional to local COVID-19 prevalence, but age-adjusted employment rates and contact behaviours also contributed. For instance, 37% of symptomatic infections occurred in Île-de-France, but 45% of sick leaves. Middle-aged workers bore disproportionately high sick leave burden, owing predominantly to greater incidence of contact sick leaves.ConclusionsFrance was heavily impacted by sick leave during the first pandemic wave, with COVID-19 contacts accounting for approximately three-quarters of COVID-19-related sick leaves. In the absence of representative sick leave registry data, local demography, employment patterns, epidemiological trends and contact behaviours can be synthesised to quantify sick leave burden and, in turn, predict economic consequences of infectious disease epidemics.
Published: 2023
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47. Identifying the Most Probable Mammal Reservoir Hosts for Monkeypox Virus Based on Ecological Niche Comparisons

Author: Manon Curaudeau, Camille Besombes, Emmanuel Nakouné, Arnaud Fontanet, Antoine Gessain, Alexandre Hassanin, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP), and This project was supported by the French Agence Nationale de Recherche (ANR 2019 CE-35) and SCOR Corporate Foundation for Science.
Subjects: Monkeypox, animal reservoir, ecological niche model, tropical Africa, evergreen forests, Sciuridae, Infectious Diseases, [SDV]Life Sciences [q-bio], Virology
Abstract: BackgroundPrevious human cases or epidemics have suggested that Monkeypox virus (MPXV) can be transmitted through contacts with animals of African rainforests. Although MPXV has been identified in many mammal species, most are likely secondary hosts and the reservoir host has yet to be discovered.Methodology/Principal FindingsIn this study, we provide the full list of African mammal genera (and species) in which MPXV was previously detected and predict the geographic distributions of all species of these genera based on museum specimens and an ecological niche modelling (ENM) method. Then, we reconstruct the ecological niche of MPXV using georeferenced data on animal MPXV sequences and human index cases, and conduct overlap analyses with the ecological niches inferred for 99 mammal species in order to identify the most probable animal reservoir.Conclusions/SignificanceOur results show that the MPXV niche covers three African rainforests, the Congo Basin and Upper and Lower Guinean forests. The four mammal species showing the best niche overlap with MPXV are all arboreal rodents, including three squirrels,Funisciurus anerythrus, Funisciurus pyrropus, andHeliosciurus rufobrachium, andGraphiurus lorraineus. We conclude that the most probable MPXV reservoir isF. anerythrusbased on two niche overlap metrics, the areas of higher probabilities of occurrence, and available data on MPXV detection.SummaryMonkeypox (MPX) is an emerging zoonotic disease, endemic to rainforests of West and Central Africa, which manifests as a fever, swollen lymph nodes, and fatigue, followed by a rash with macular lesions progressing from papules to vesicles, pustules and scabs, usually on the face, hands, and feet for two to four weeks. The case fatality rate ranges from 1-3% in West Africa to 5-10% in Central Africa. The disease has been reported in 10 African countries between 1970 and today, with an increasing number of cases over the last decades and several exportations outside the continent, the last one in 2022 resulting in an epidemic involving mostly men who have sex with men, with more than 80,000 cases detected worldwide.Although MPX virus has been identified in many mammal species, most are likely secondary hosts and the reservoir host has yet to be discovered. In this study, we compare the predicted geographic distribution (ecological niche) of the MPX virus with that of 99 mammal species, and conclude that the most probable MPX reservoir is Thomas’s rope squirrel (Funisciurus anerythrus), followed by three other arboreal rodents, including two squirrels (Funisciurus pyrropusandHeliosciurus rufobrachium) and the Lorrain dormouse (Graphiurus lorraineus).
Published: 2023
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48. Heterogeneity of design features in studies included in systematic reviews with meta‐analysis of cognitive outcomes in children born very preterm

Author: Mariane Sentenac, Sabrina Twilhaar, Valérie Benhammou, Andrei S. Morgan, Samantha Johnson, Anna Chaimani, Jennifer Zeitlin, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Neonatal Medicine of Port-Royal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Health Sciences [Leicester], University of Leicester, Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), and European Project: 733280,RECAP preterm
Subjects: cognition, meta-analysis, [STAT]Statistics [stat], very low birthweight, Epidemiology, Pediatrics, Perinatology and Child Health, preterm infants, heterogeneity
Abstract: International audience; BackgroundMeta-analyses of the voluminous scientific literature on the impact of very preterm (VPT
Published: 2023
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49. IPR-based distributed interval observers design for uncertain LTI systems

Author: Danxia Li, Weisheng Chen, Jing Chang, Tarek Raïssi, Xidian University, CEDRIC. Traitement du signal et architectures électroniques (CEDRIC - LAETITIA), Centre d'études et de recherche en informatique et communications (CEDRIC), and Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)
Subjects: 0209 industrial biotechnology, Observer (quantum physics), Applied Mathematics, 020208 electrical & electronic engineering, Synchronizing, 02 engineering and technology, Interval (mathematics), Upper and lower bounds, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Computer Science Applications, LTI system theory, 020901 industrial engineering & automation, Control and Systems Engineering, Control theory, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Instrumentation, ComputingMilieux_MISCELLANEOUS, Mathematics
Abstract: This paper designs a novel distributed interval observer for Linear Time Invariant (LTI) systems with additive disturbances. The technique of observer construction relies on the Internal Positive Representations (IPRs) of systems and synchronizing region approach, which ensures that the error system is stably and positive. Each observer estimates the upper and lower bounds (ULBs) of the system states by only using part of the output information and the information interaction with their neighbors. Numerical examples are simulated to demonstrate the effectiveness of the proposed approach.
Published: 2022
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50. The potential effects of meat substitution on diet quality could be high if meat substitutes are optimized for nutritional composition—a modeling study in French adults (INCA3)

Author: Marion Salomé, François Mariotti, Marie-Charlotte Nicaud, Alison Dussiot, Emmanuelle Kesse-Guyot, Marie-Noëlle Maillard, Jean-François Huneau, Hélène Fouillet, Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-AgroParisTech, Paris-Saclay Food and Bioproduct Engineering (SayFood), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), and Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Dietary Fiber, Meat, Nutrition and Dietetics, [SDV]Life Sciences [q-bio], Mathematical optimization, food and beverages, Medicine (miscellaneous), Plant-based substitutes, Nutrients, Diet, Nonlinear programming, Nutrient composition, Nutritive Value, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Diet quality
Abstract: International audience; Purpose. While consumer demand for meat substitutes is growing, their varied composition raises questions regarding their nutritional value. We aimed to identify and characterize the optimal composition of a meat substitute that would best improve diet quality after complete meat replacement.Methods. From an average individual representing the dietary intake of French adults (INCA3, n=1125), meat was replaced with an equivalent amount of a mostly pulse-based substitute, whose composition was based on a list of 159 possible plant ingredients and optimized non-linearly to maximize diet quality assessed with the PANDiet score (considering adequacy for 32 nutrients), while taking account of technological constraints and applying nutritional constraints to limit the risk of overt deficiency in 12 key nutrients.Results. The optimized meat substitute contained 13 minimally processed ingredients. When used to substitute meat, the PANDiet score increased by 5.7 points above its initial value before substitution (versus -3.1 to +1.5 points when using other substitutes on the market), mainly because of higher intakes of nutrients that are currently insufficiently consumed (e.g. alpha-linolenic acid, fiber, linoleic acid) and a lower SFA intake. The meat substitute also mostly compensated for the lower provision of some indispensable nutrients to which meat greatly contributed (e.g. vitamin B6, potassium, bioavailable iron), but it could not compensate for bioavailable zinc and vitamin B12. Conclusion. Choosing the correct ingredients can result in a nutritionally highly effective meat substitute that could compensate for reductions in many nutrients supplied by meat while providing key nutrients that are currently insufficiently consumed.
Published: 2022
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