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3. Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy

Author

Park, B.-y., Larivière, S., Rodríguez-Cruces, R., Royer, J., Tavakol, S., Wang, Y., Caciagli, L., Caligiuri, M.E., Gambardella, A., Concha, L., Keller, S.S., Cendes, F., Alvim, M.K.M., Yasuda, C., Bonilha, L., Gleichgerrcht, E., Focke, N.K., Kreilkamp, B.A.K., Domin, M., Podewils, F. von, Langner, S., Rummel, C., Rebsamen, M., Wiest, R., Martin, P., Kotikalapudi, R., Bender, B., O’Brien, T.J., Law, M., Sinclair, B., Vivash, L., Kwan, P., Desmond, P.M., Malpas, C.B., Lui, E., Alhusaini, S., Doherty, C.P., Cavalleri, G.L., Delanty, N., Kälviäinen, R., Jackson, G.D., Kowalczyk, M., Mascalchi, M., Semmelroch, M., Thomas, R.H., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Lenge, M., Guerrini, R., Bartolini, E., Hamandi, K., Foley, S., Weber, B., Depondt, C., Absil, J., Carr, S.J.A., Abela, E., Richardson, M.P., Devinsky, O., Severino, M., Striano, P., Parodi, C., Tortora, D., Hatton, S.N., Vos, S.B., Duncan, J.S., Galovic, M., Whelan, C.D., Bargalló, N., Pariente, J., Conde-Blanco, E., Vaudano, A.E., Tondelli, M., Meletti, S., Kong, X.Z., Francks, C., Fisher, S.E., Caldairou, B., Ryten, M., Labate, A., Sisodiya, S.M., Thompson, P.M., McDonald, C.R., Bernasconi, A., Bernasconi, N., Bernhardt, B.C., Park, B.-y., Larivière, S., Rodríguez-Cruces, R., Royer, J., Tavakol, S., Wang, Y., Caciagli, L., Caligiuri, M.E., Gambardella, A., Concha, L., Keller, S.S., Cendes, F., Alvim, M.K.M., Yasuda, C., Bonilha, L., Gleichgerrcht, E., Focke, N.K., Kreilkamp, B.A.K., Domin, M., Podewils, F. von, Langner, S., Rummel, C., Rebsamen, M., Wiest, R., Martin, P., Kotikalapudi, R., Bender, B., O’Brien, T.J., Law, M., Sinclair, B., Vivash, L., Kwan, P., Desmond, P.M., Malpas, C.B., Lui, E., Alhusaini, S., Doherty, C.P., Cavalleri, G.L., Delanty, N., Kälviäinen, R., Jackson, G.D., Kowalczyk, M., Mascalchi, M., Semmelroch, M., Thomas, R.H., Soltanian-Zadeh, H., Davoodi-Bojd, E., Zhang, J., Lenge, M., Guerrini, R., Bartolini, E., Hamandi, K., Foley, S., Weber, B., Depondt, C., Absil, J., Carr, S.J.A., Abela, E., Richardson, M.P., Devinsky, O., Severino, M., Striano, P., Parodi, C., Tortora, D., Hatton, S.N., Vos, S.B., Duncan, J.S., Galovic, M., Whelan, C.D., Bargalló, N., Pariente, J., Conde-Blanco, E., Vaudano, A.E., Tondelli, M., Meletti, S., Kong, X.Z., Francks, C., Fisher, S.E., Caldairou, B., Ryten, M., Labate, A., Sisodiya, S.M., Thompson, P.M., McDonald, C.R., Bernasconi, A., Bernasconi, N., and Bernhardt, B.C.

Abstract

Contains fulltext : 252489.pdf (Publisher’s version ) (Open Access)

Published
2022

4. Imaging characteristics of temporopolar blurring in the context of hippocampal sclerosis

Author

Prado, CAC, Federico, P, Bernasconi, A, Bernhardt, B, Caciagli, L, Concha, L, Chinvarun, Y, Jackson, G, Morgan, V, Rampp, S, Vaudano, AE, Wang, I, Wang, S, Zaidan, BC, Rogerio, F, Cendes, F, Prado, CAC, Federico, P, Bernasconi, A, Bernhardt, B, Caciagli, L, Concha, L, Chinvarun, Y, Jackson, G, Morgan, V, Rampp, S, Vaudano, AE, Wang, I, Wang, S, Zaidan, BC, Rogerio, F, and Cendes, F

Abstract

We present an illustrative case to address anterior temporal lobe atrophy with poor delineation of the temporopolar gray-white matter interface based on T2-weighted and fluid-attenuated inversion recovery (FLAIR) images in patients with temporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS). A 52-year-old woman with pharmacoresistant seizures since the age of six months underwent a previous MRI scan using a suboptimal protocol which was reported as unremarkable. MRI performed according to an epilepsy protocol showed classic signs of left HS and ipsilateral temporal polar atrophy with blurring of the gray-white matter boundary on FLAIR images. She underwent a left amygdalohippocampectomy and anterior temporal resection and remains seizure-free after 24 months. Histopathological analyses showed HS and no signs of focal cortical dysplasia (FCD). Blurring and atrophy of the ipsilateral temporal pole are common in TLE-HS and often misinterpreted as FCD. This relates to delayed myelination in patients with seizures before the age of two, is more pronounced on FLAIR sequences, and gives a false impression of cortical thickening. However, the T1-weighted images show a relatively well-demarcated cortical-subcortical transition and normal cortical thickness. By contrast, the cortical thickening in FCD is observed on both T1-weighted and FLAIR images. Since FCD also occurs in temporal lobe regions, it is important to differentiate the extra-hippocampal MRI abnormalities in TLE-HS from those likely to be FCD. This case highlights the importance of evaluation based on detailed imaging, which should always be conducted considering the EEG, seizure semiology, and other clinical information.

Published
2022

5. Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy

Author

Park, B-Y, Lariviere, S, Rodriguez-Cruces, R, Royer, J, Tavakol, S, Wang, Y, Caciagli, L, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Alvim, MKM, Yasuda, C, Bonilha, L, Gleichgerrcht, E, Focke, NK, Kreilkamp, BAK, Domin, M, von Podewils, F, Langner, S, Rummel, C, Rebsamen, M, Wiest, R, Martin, P, Kotikalapudi, R, Bender, B, O'Brien, TJ, Law, M, Sinclair, B, Vivash, L, Kwan, P, Desmond, PM, Malpas, CB, Lui, E, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Lenge, M, Guerrini, R, Bartolini, E, Hamandi, K, Foley, S, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Parodi, C, Tortora, D, Hatton, SN, Vos, SB, Duncan, JS, Galovic, M, Whelan, CD, Bargallo, N, Pariente, J, Conde-Blanco, E, Vaudano, AE, Tondelli, M, Meletti, S, Kong, X-Z, Francks, C, Fisher, SE, Caldairou, B, Ryten, M, Labate, A, Sisodiya, SM, Thompson, PM, McDonald, CR, Bernasconi, A, Bernasconi, N, Bernhardt, BC, Park, B-Y, Lariviere, S, Rodriguez-Cruces, R, Royer, J, Tavakol, S, Wang, Y, Caciagli, L, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Alvim, MKM, Yasuda, C, Bonilha, L, Gleichgerrcht, E, Focke, NK, Kreilkamp, BAK, Domin, M, von Podewils, F, Langner, S, Rummel, C, Rebsamen, M, Wiest, R, Martin, P, Kotikalapudi, R, Bender, B, O'Brien, TJ, Law, M, Sinclair, B, Vivash, L, Kwan, P, Desmond, PM, Malpas, CB, Lui, E, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Lenge, M, Guerrini, R, Bartolini, E, Hamandi, K, Foley, S, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Parodi, C, Tortora, D, Hatton, SN, Vos, SB, Duncan, JS, Galovic, M, Whelan, CD, Bargallo, N, Pariente, J, Conde-Blanco, E, Vaudano, AE, Tondelli, M, Meletti, S, Kong, X-Z, Francks, C, Fisher, SE, Caldairou, B, Ryten, M, Labate, A, Sisodiya, SM, Thompson, PM, McDonald, CR, Bernasconi, A, Bernasconi, N, and Bernhardt, BC

Abstract

Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an in vivo window into whole-brain grey matter structural alterations in temporal lobe epilepsy relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both atypical asymmetry and regional atrophy measures have not been systematically investigated. Here, we addressed this gap using the multisite ENIGMA-Epilepsy dataset comprising MRI brain morphological measures in 732 temporal lobe epilepsy patients and 1418 healthy controls. We compared spatial distributions of grey matter asymmetry and atrophy in temporal lobe epilepsy, contextualized their topographies relative to spatial gradients in cortical microstructure and functional connectivity calculated using 207 healthy controls obtained from Human Connectome Project and an independent dataset containing 23 temporal lobe epilepsy patients and 53 healthy controls and examined clinical associations using machine learning. We identified a marked divergence in the spatial distribution of atypical inter-hemispheric asymmetry and regional atrophy mapping. The former revealed a temporo-limbic disease signature while the latter showed diffuse and bilateral patterns. Our findings were robust across individual sites and patients. Cortical atrophy was significantly correlated with disease duration and age at seizure onset, while degrees of asymmetry did not show a significant relationship to these clinical variables. Our findings highlight that the mapping of atypical inter-hemispheric asymmetry and regional atrophy tap into two complementary aspects of temporal lobe epilepsy-related pathology, with the former revealing primary substrates in ipsilateral limbic circuits and the latter capturing bilateral disease effects. These findings refine ou

Published
2022

6. A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies

Author

Altmann, A, Ryten, M, Di Nunzio, M, Ravizza, T, Tolomeo, D, Reynolds, RH, Somani, A, Bacigaluppi, M, Iori, V, Micotti, E, Di Sapia, R, Cerovic, M, Palma, E, Ruffolo, G, Botia, JA, Absil, J, Alhusaini, S, Alvim, MKM, Auvinen, P, Bargallo, N, Bartolini, E, Bender, B, Bergo, FPG, Bernardes, T, Bernasconi, A, Bernasconi, N, Bernhardt, BC, Blackmon, K, Braga, B, Caligiuri, ME, Calvo, A, Carlson, C, Carr, SJA, Cavalleri, GL, Cendes, F, Chen, J, Chen, S, Cherubini, A, Concha, L, David, P, Delanty, N, Depondt, C, Devinsky, O, Doherty, CP, Domin, M, Focke, NK, Foley, S, Franca, W, Gambardella, A, Guerrini, R, Hamandi, K, Hibar, DP, Isaev, D, Jackson, GD, Jahanshad, N, Kalviainen, R, Keller, SS, Kochunov, P, Kotikalapudi, R, Kowalczyk, MA, Kuzniecky, R, Kwan, P, Labate, A, Langner, S, Lenge, M, Liu, M, Martin, P, Mascalchi, M, Meletti, S, Morita-Sherman, ME, O'Brien, TJ, Pariente, JC, Richardson, MP, Rodriguez-Cruces, R, Rummel, C, Saavalainen, T, Semmelroch, MK, Severino, M, Striano, P, Thesen, T, Thomas, RH, Tondelli, M, Tortora, D, Vaudano, AE, Vivash, L, Podewils, F, Wagner, J, Weber, B, Wiest, R, Yasuda, CL, Zhang, G, Zhang, J, Leu, C, Avbersek, A, Thom, M, Whelan, CD, Thompson, P, McDonald, CR, Vezzani, A, Sisodiya, SM, Altmann, A, Ryten, M, Di Nunzio, M, Ravizza, T, Tolomeo, D, Reynolds, RH, Somani, A, Bacigaluppi, M, Iori, V, Micotti, E, Di Sapia, R, Cerovic, M, Palma, E, Ruffolo, G, Botia, JA, Absil, J, Alhusaini, S, Alvim, MKM, Auvinen, P, Bargallo, N, Bartolini, E, Bender, B, Bergo, FPG, Bernardes, T, Bernasconi, A, Bernasconi, N, Bernhardt, BC, Blackmon, K, Braga, B, Caligiuri, ME, Calvo, A, Carlson, C, Carr, SJA, Cavalleri, GL, Cendes, F, Chen, J, Chen, S, Cherubini, A, Concha, L, David, P, Delanty, N, Depondt, C, Devinsky, O, Doherty, CP, Domin, M, Focke, NK, Foley, S, Franca, W, Gambardella, A, Guerrini, R, Hamandi, K, Hibar, DP, Isaev, D, Jackson, GD, Jahanshad, N, Kalviainen, R, Keller, SS, Kochunov, P, Kotikalapudi, R, Kowalczyk, MA, Kuzniecky, R, Kwan, P, Labate, A, Langner, S, Lenge, M, Liu, M, Martin, P, Mascalchi, M, Meletti, S, Morita-Sherman, ME, O'Brien, TJ, Pariente, JC, Richardson, MP, Rodriguez-Cruces, R, Rummel, C, Saavalainen, T, Semmelroch, MK, Severino, M, Striano, P, Thesen, T, Thomas, RH, Tondelli, M, Tortora, D, Vaudano, AE, Vivash, L, Podewils, F, Wagner, J, Weber, B, Wiest, R, Yasuda, CL, Zhang, G, Zhang, J, Leu, C, Avbersek, A, Thom, M, Whelan, CD, Thompson, P, McDonald, CR, Vezzani, A, and Sisodiya, SM

Abstract

AIMS: The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems-level analysis. METHODS: Imaging-based cortical structural maps from a large-scale epilepsy neuroimaging study were overlaid with highly spatially resolved human brain gene expression data from the Allen Human Brain Atlas. Cell-type deconvolution, differential expression analysis and cell-type enrichment analyses were used to identify differences in cell-type distribution. These differences were followed up in post-mortem brain tissue from humans with epilepsy using Iba1 immunolabelling. Furthermore, to investigate a causal effect in cortical thinning, cell-type-specific depletion was used in a murine model of acquired epilepsy. RESULTS: We identified elevated fractions of microglia and endothelial cells in regions of reduced cortical thickness. Differentially expressed genes showed enrichment for microglial markers and, in particular, activated microglial states. Analysis of post-mortem brain tissue from humans with epilepsy confirmed excess activated microglia. In the murine model, transient depletion of activated microglia during the early phase of the disease development prevented cortical thinning and neuronal cell loss in the temporal cortex. Although the development of chronic seizures was unaffected, the epileptic mice with early depletion of activated microglia did not develop deficits in a non-spatial memory test seen in epileptic mice not depleted of microglia. CONCLUSIONS: These convergent data strongly implicate activated microglia in cortical thinning, representing a new dimension for concern and disease modification in the epilepsies, potentially distinct from seizure control.

Published
2022

7. The ENIGMA-Epilepsy working group: Mapping disease from large data sets

Author

Sisodiya, SM, Whelan, CD, Hatton, SN, Huynh, K, Altmann, A, Ryten, M, Vezzani, A, Caligiuri, ME, Labate, A, Gambardella, A, Ives-Deliperi, V, Meletti, S, Munsell, BC, Bonilha, L, Tondelli, M, Rebsamen, M, Rummel, C, Vaudano, AE, Wiest, R, Balachandra, AR, Bargallo, N, Bartolini, E, Bernasconi, A, Bernasconi, N, Bernhardt, B, Caldairou, B, Carr, SJA, Cavalleri, GL, Cendes, F, Concha, L, Desmond, PM, Domin, M, Duncan, JS, Focke, NK, Guerrini, R, Hamandi, K, Jackson, GD, Jahanshad, N, Kalviainen, R, Keller, SS, Kochunov, P, Kowalczyk, MA, Kreilkamp, BAK, Kwan, P, Lariviere, S, Lenge, M, Lopez, SM, Martin, P, Mascalchi, M, Moreira, JCV, Morita-Sherman, ME, Pardoe, HR, Pariente, JC, Raviteja, K, Rocha, CS, Rodriguez-Cruces, R, Seeck, M, Semmelroch, MKHG, Sinclair, B, Soltanian-Zadeh, H, Stein, DJ, Striano, P, Taylor, PN, Thomas, RH, Thomopoulos, SI, Velakoulis, D, Vivash, L, Weber, B, Yasuda, CL, Zhang, J, Thompson, PM, McDonald, CR, Sisodiya, SM, Whelan, CD, Hatton, SN, Huynh, K, Altmann, A, Ryten, M, Vezzani, A, Caligiuri, ME, Labate, A, Gambardella, A, Ives-Deliperi, V, Meletti, S, Munsell, BC, Bonilha, L, Tondelli, M, Rebsamen, M, Rummel, C, Vaudano, AE, Wiest, R, Balachandra, AR, Bargallo, N, Bartolini, E, Bernasconi, A, Bernasconi, N, Bernhardt, B, Caldairou, B, Carr, SJA, Cavalleri, GL, Cendes, F, Concha, L, Desmond, PM, Domin, M, Duncan, JS, Focke, NK, Guerrini, R, Hamandi, K, Jackson, GD, Jahanshad, N, Kalviainen, R, Keller, SS, Kochunov, P, Kowalczyk, MA, Kreilkamp, BAK, Kwan, P, Lariviere, S, Lenge, M, Lopez, SM, Martin, P, Mascalchi, M, Moreira, JCV, Morita-Sherman, ME, Pardoe, HR, Pariente, JC, Raviteja, K, Rocha, CS, Rodriguez-Cruces, R, Seeck, M, Semmelroch, MKHG, Sinclair, B, Soltanian-Zadeh, H, Stein, DJ, Striano, P, Taylor, PN, Thomas, RH, Thomopoulos, SI, Velakoulis, D, Vivash, L, Weber, B, Yasuda, CL, Zhang, J, Thompson, PM, and McDonald, CR

Abstract

Epilepsy is a common and serious neurological disorder, with many different constituent conditions characterized by their electro clinical, imaging, and genetic features. MRI has been fundamental in advancing our understanding of brain processes in the epilepsies. Smaller-scale studies have identified many interesting imaging phenomena, with implications both for understanding pathophysiology and improving clinical care. Through the infrastructure and concepts now well-established by the ENIGMA Consortium, ENIGMA-Epilepsy was established to strengthen epilepsy neuroscience by greatly increasing sample sizes, leveraging ideas and methods established in other ENIGMA projects, and generating a body of collaborating scientists and clinicians to drive forward robust research. Here we review published, current, and future projects, that include structural MRI, diffusion tensor imaging (DTI), and resting state functional MRI (rsfMRI), and that employ advanced methods including structural covariance, and event-based modeling analysis. We explore age of onset- and duration-related features, as well as phenomena-specific work focusing on particular epilepsy syndromes or phenotypes, multimodal analyses focused on understanding the biology of disease progression, and deep learning approaches. We encourage groups who may be interested in participating to make contact to further grow and develop ENIGMA-Epilepsy.

Published
2022

8. Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Author

Lariviere, S, Royer, J, Rodriguez-Cruces, R, Paquola, C, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Yasuda, CL, Bonilha, L, Gleichgerrcht, E, Focke, NK, Domin, M, von Podewills, F, Langner, S, Rummel, C, Wiest, R, Martin, P, Kotikalapudi, R, O'Brien, TJ, Sinclair, B, Vivash, L, Desmond, PM, Lui, E, Vaudano, AE, Meletti, S, Tondelli, M, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Winston, GP, Griffin, A, Singh, A, Tiwari, VK, Kreilkamp, BAK, Lenge, M, Guerrini, R, Hamandi, K, Foley, S, Ruber, T, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Tortora, D, Kaestner, E, Hatton, SN, Vos, SB, Caciagli, L, Duncan, JS, Whelan, CD, Thompson, PM, Sisodiya, SM, Bernasconi, A, Labate, A, McDonald, CR, Bernasconi, N, Bernhardt, BC, Lariviere, S, Royer, J, Rodriguez-Cruces, R, Paquola, C, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Yasuda, CL, Bonilha, L, Gleichgerrcht, E, Focke, NK, Domin, M, von Podewills, F, Langner, S, Rummel, C, Wiest, R, Martin, P, Kotikalapudi, R, O'Brien, TJ, Sinclair, B, Vivash, L, Desmond, PM, Lui, E, Vaudano, AE, Meletti, S, Tondelli, M, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Winston, GP, Griffin, A, Singh, A, Tiwari, VK, Kreilkamp, BAK, Lenge, M, Guerrini, R, Hamandi, K, Foley, S, Ruber, T, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Tortora, D, Kaestner, E, Hatton, SN, Vos, SB, Caciagli, L, Duncan, JS, Whelan, CD, Thompson, PM, Sisodiya, SM, Bernasconi, A, Labate, A, McDonald, CR, Bernasconi, N, and Bernhardt, BC

Abstract

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.

Published
2022

10. Reorientación comunitaria de la atención primaria en un área de salud: proyecto ROCAP

Author

Marivi Verdeguer Gómez, Concha Llopis Tortosa, Miguel Murcia Soler, Joan Paredes Carbonell, José Manuel Soler Torro, and Carlos Herrero Gil

Subjects
Primary care, Reorientation, Community health, Health promotion, Medicine (General), R5-920
Abstract

Resumen: Objetivo: Evaluar la efectividad de una intervención para incorporar actividades grupales y comunitarias de forma sostenida en todas las Zonas Básicas de Salud (ZBS) de un área de salud. Diseño: Durante enero y febrero de 2019 dos miembros del equipo investigador se desplazaron a cada ZBS para entrevistarse con los coordinadores médicos y de enfermería que habían recibido previamente por correo electrónico un cuestionario de evaluación inicial (QAI) elaborado ad hoc. Sitio: El ámbito son las 11 ZBS de un área de salud. Participantes: La población de estudio son las ZBS y los respectivos equipos representados por las coordinaciones médicas y de enfermería. Intervenciones: Impulsar una comisión de salud comunitaria, realizar acciones formativas, registro de actividades en historia clínica e incorporar objetivos de gestión. Mediciones principales: Se realizó análisis cuantitativo y cualitativo pre y post tras el primer año de intervención. Resultados: En la evaluación pre: 6 equipos de atención primaria (EAP) refirieron tener actividades grupales, 4 estaban participando en proyectos de acción local, 4 tenían un profesional referente de las actividades comunitarias, 3 participaban en proyectos con población en situación de vulnerabilidad y 4 manifestaron tener reuniones específicas sobre salud comunitaria. Tras la intervención: 11 EAP tenían actividades grupales, 8 un profesional referente, 6 estaban participando en proyectos de acción local, 4 colaboraban en proyectos con población vulnerable y 5 mantenían reuniones sobre salud comunitaria. Conclusiones: La intervención se mostró efectiva tras su primer año de implementación, ya que todos los EAP realizaban actividades grupales y colaboraban con los ayuntamientos de la zona; la mayoría tenían profesionales referentes en atención comunitaria y, en menor medida, se incrementó la participación en proyectos de acción local y en población en situación de vulnerabilidad. Abstract: Aim: Evaluate the effectiveness of an intervention to incorporate group and community activities on a sustained basis in all the Basic Health Zones (ZBS) of a health area. Design: During January and February 2019, two members of the research team traveled to each ZBS to interview the medical and nursing coordinators who had previously received an ad hoc initial assessment questionnaire (QAI) by email. Place: The scope is the 11 ZBS of a health area. Participants: The study population is the ZBS and the respective teams represented by the medical and nursing coordinations. Interventions: Promote a community health commission, carry out training actions, record activities in clinical history and incorporate management objectives. Main measurements: Quantitative and qualitative analysis was carried out pre and post after the first year of intervention. Results: In the pre-evaluation: 6 primary care teams (EAP) reported having group activities, 4 were participating in local action projects, 4 had a professional referent for community activities, 3 participated in projects with populations in vulnerable situations and 4 stated have specific meetings on community health. After the intervention: 11 EAPs had group activities, 8 had a reference professional, 6 were participating in local action projects, 4 collaborated in projects with vulnerable populations and 5 held meetings on community health. Conclusions: The intervention proved effective after its first year of implementation, since all the EAPs carried out group activities and collaborated with the local councils in the area; the majority had leading professionals in community care and, to a lesser extent, participation in local action projects and in vulnerable populations increased.

Published
2024
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11. Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?

Author

Schilling, KG, Rheault, F, Petit, L, Hansen, CB, Nath, V, Yeh, F-C, Girard, G, Barakovic, M, Rafael-Patino, J, Yu, T, Fischi-Gomez, E, Pizzolato, M, Ocampo-Pineda, M, Schiavi, S, Canales-Rodriguez, EJ, Daducci, A, Granziera, C, Innocenti, G, Thiran, J-P, Mancini, L, Wastling, S, Cocozza, S, Petracca, M, Pontillo, G, Mancini, M, Vos, SB, Vakharia, VN, Duncan, JS, Melero, H, Manzanedo, L, Sanz-Morales, E, Pena-Melian, A, Calamante, F, Attye, A, Cabeen, RP, Korobova, L, Toga, AW, Vijayakumari, AA, Parker, D, Verma, R, Radwan, A, Sunaert, S, Emsell, L, De Luca, A, Leemans, A, Bajada, CJ, Haroon, H, Azadbakht, H, Chamberland, M, Genc, S, Tax, CMW, Yeh, P-H, Srikanchana, R, Mcknight, CD, Yang, JY-M, Chen, J, Kelly, CE, Yeh, C-H, Cochereau, J, Maller, JJ, Welton, T, Almairac, F, Seunarine, KK, Clark, CA, Zhang, F, Makris, N, Golby, A, Rathi, Y, O'Donnell, LJ, Xia, Y, Aydogan, DB, Shi, Y, Fernandes, FG, Raemaekers, M, Warrington, S, Michielse, S, Ramirez-Manzanares, A, Concha, L, Aranda, R, Meraz, MR, Lerma-Usabiaga, G, Roitman, L, Fekonja, LS, Calarco, N, Joseph, M, Nakua, H, Voineskos, AN, Karan, P, Grenier, G, Legarreta, JH, Adluru, N, Nair, VA, Prabhakaran, V, Alexander, AL, Kamagata, K, Saito, Y, Uchida, W, Andica, C, Abe, M, Bayrak, RG, Wheeler-Kingshott, CAMG, D'Angelo, E, Palesi, F, Savini, G, Rolandi, N, Guevara, P, Houenou, J, Lopez-Lopez, N, Mangin, J-F, Poupon, C, Roman, C, Vazquez, A, Maffei, C, Arantes, M, Andrade, JP, Silva, SM, Calhoun, VD, Caverzasi, E, Sacco, S, Lauricella, M, Pestilli, F, Bullock, D, Zhan, Y, Brignoni-Perez, E, Lebel, C, Reynolds, JE, Nestrasil, I, Labounek, R, Lenglet, C, Paulson, A, Aulicka, S, Heilbronner, SR, Heuer, K, Chandio, BQ, Guaje, J, Tang, W, Garyfallidis, E, Raja, R, Anderson, AW, Landman, BA, Descoteaux, M, Schilling, KG, Rheault, F, Petit, L, Hansen, CB, Nath, V, Yeh, F-C, Girard, G, Barakovic, M, Rafael-Patino, J, Yu, T, Fischi-Gomez, E, Pizzolato, M, Ocampo-Pineda, M, Schiavi, S, Canales-Rodriguez, EJ, Daducci, A, Granziera, C, Innocenti, G, Thiran, J-P, Mancini, L, Wastling, S, Cocozza, S, Petracca, M, Pontillo, G, Mancini, M, Vos, SB, Vakharia, VN, Duncan, JS, Melero, H, Manzanedo, L, Sanz-Morales, E, Pena-Melian, A, Calamante, F, Attye, A, Cabeen, RP, Korobova, L, Toga, AW, Vijayakumari, AA, Parker, D, Verma, R, Radwan, A, Sunaert, S, Emsell, L, De Luca, A, Leemans, A, Bajada, CJ, Haroon, H, Azadbakht, H, Chamberland, M, Genc, S, Tax, CMW, Yeh, P-H, Srikanchana, R, Mcknight, CD, Yang, JY-M, Chen, J, Kelly, CE, Yeh, C-H, Cochereau, J, Maller, JJ, Welton, T, Almairac, F, Seunarine, KK, Clark, CA, Zhang, F, Makris, N, Golby, A, Rathi, Y, O'Donnell, LJ, Xia, Y, Aydogan, DB, Shi, Y, Fernandes, FG, Raemaekers, M, Warrington, S, Michielse, S, Ramirez-Manzanares, A, Concha, L, Aranda, R, Meraz, MR, Lerma-Usabiaga, G, Roitman, L, Fekonja, LS, Calarco, N, Joseph, M, Nakua, H, Voineskos, AN, Karan, P, Grenier, G, Legarreta, JH, Adluru, N, Nair, VA, Prabhakaran, V, Alexander, AL, Kamagata, K, Saito, Y, Uchida, W, Andica, C, Abe, M, Bayrak, RG, Wheeler-Kingshott, CAMG, D'Angelo, E, Palesi, F, Savini, G, Rolandi, N, Guevara, P, Houenou, J, Lopez-Lopez, N, Mangin, J-F, Poupon, C, Roman, C, Vazquez, A, Maffei, C, Arantes, M, Andrade, JP, Silva, SM, Calhoun, VD, Caverzasi, E, Sacco, S, Lauricella, M, Pestilli, F, Bullock, D, Zhan, Y, Brignoni-Perez, E, Lebel, C, Reynolds, JE, Nestrasil, I, Labounek, R, Lenglet, C, Paulson, A, Aulicka, S, Heilbronner, SR, Heuer, K, Chandio, BQ, Guaje, J, Tang, W, Garyfallidis, E, Raja, R, Anderson, AW, Landman, BA, and Descoteaux, M

Abstract

White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways, which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography, including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human whole-brain streamlines and asked to segment 14 white matter fascicles on six subjects. In total, we received 57 different bundle segmentation protocols, which enabled detailed volume-based and streamline-based analyses of agreement and disagreement among protocols for each fiber pathway. Results show that even when given the exact same sets of underlying streamlines, the variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection process, including variability within protocols and variability across subjects. In order to foster the use of tractography bundle dissection in routine clinical settings, and as a fundamental analytical tool, future endeavors must aim to resolve and reduce this heterogeneity. Although external validation is needed to verify the anatomical accuracy of bundle dissections, reducing heterogeneity is a step towards reproducible research and may be achieved through the use of standard nomenclature and definitions of white matter bundles and well-chosen constraints and decisions in the dissection process.

Published
2021

12. Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study

Author

Gleichgerrcht, E, Munsell, BC, Alhusaini, S, Alvim, MKM, Bargallo, N, Bender, B, Bernasconi, A, Bernasconi, N, Bernhardt, B, Blackmon, K, Caligiuri, ME, Cendes, F, Concha, L, Desmond, PM, Devinsky, O, Doherty, CP, Domin, M, Duncan, JS, Focke, NK, Gambardella, A, Gong, B, Guerrini, R, Hatton, SN, Kalviainen, R, Keller, SS, Kochunov, P, Kotikalapudi, R, Kreilkamp, BAK, Labate, A, Langner, S, Lariviere, S, Lenge, M, Lui, E, Martin, P, Mascalchi, M, Meletti, S, O'Brien, TJ, Pardoe, HR, Pariente, JC, Rao, JX, Richardson, MP, Rodriguez-Cruces, R, Ruber, T, Sinclair, B, Soltanian-Zadeh, H, Stein, DJ, Striano, P, Taylor, PN, Thomas, RH, Vaudano, AE, Vivash, L, von Podewills, F, Vos, SB, Weber, B, Yao, Y, Yasuda, CL, Zhang, J, Thompson, PM, Sisodiya, SM, McDonald, CR, Bonilha, L, Gleichgerrcht, E, Munsell, BC, Alhusaini, S, Alvim, MKM, Bargallo, N, Bender, B, Bernasconi, A, Bernasconi, N, Bernhardt, B, Blackmon, K, Caligiuri, ME, Cendes, F, Concha, L, Desmond, PM, Devinsky, O, Doherty, CP, Domin, M, Duncan, JS, Focke, NK, Gambardella, A, Gong, B, Guerrini, R, Hatton, SN, Kalviainen, R, Keller, SS, Kochunov, P, Kotikalapudi, R, Kreilkamp, BAK, Labate, A, Langner, S, Lariviere, S, Lenge, M, Lui, E, Martin, P, Mascalchi, M, Meletti, S, O'Brien, TJ, Pardoe, HR, Pariente, JC, Rao, JX, Richardson, MP, Rodriguez-Cruces, R, Ruber, T, Sinclair, B, Soltanian-Zadeh, H, Stein, DJ, Striano, P, Taylor, PN, Thomas, RH, Vaudano, AE, Vivash, L, von Podewills, F, Vos, SB, Weber, B, Yao, Y, Yasuda, CL, Zhang, J, Thompson, PM, Sisodiya, SM, McDonald, CR, and Bonilha, L

Abstract

Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role of machine learning and artificial intelligence to increase detection of brain abnormalities in TLE remains inconclusive. We used support vector machine (SV) and deep learning (DL) models based on region of interest (ROI-based) structural (n = 336) and diffusion (n = 863) brain MRI data from patients with TLE with ("lesional") and without ("non-lesional") radiographic features suggestive of underlying hippocampal sclerosis from the multinational (multi-center) ENIGMA-Epilepsy consortium. Our data showed that models to identify TLE performed better or similar (68-75%) compared to models to lateralize the side of TLE (56-73%, except structural-based) based on diffusion data with the opposite pattern seen for structural data (67-75% to diagnose vs. 83% to lateralize). In other aspects, structural and diffusion-based models showed similar classification accuracies. Our classification models for patients with hippocampal sclerosis were more accurate (68-76%) than models that stratified non-lesional patients (53-62%). Overall, SV and DL models performed similarly with several instances in which SV mildly outperformed DL. We discuss the relative performance of these models with ROI-level data and the implications for future applications of machine learning and artificial intelligence in epilepsy care.

Published
2021

14. Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

Author

Lariviere, S, Rodriguez-Cruces, R, Royer, J, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Yasuda, C, Bonilha, L, Gleichgerrcht, E, Focke, NK, Domin, M, von Podewills, F, Langner, S, Rummel, C, Wiest, R, Martin, P, Kotikalapudi, R, O'Brien, TJ, Sinclair, B, Vivash, L, Desmond, PM, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Lenge, M, Guerrini, R, Bartolini, E, Hamandi, K, Foley, S, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Tortora, D, Hatton, SN, Vos, SB, Duncan, JS, Whelan, CD, Thompson, PM, Sisodiya, SM, Bernasconi, A, Labate, A, McDonald, CR, Bernasconi, N, Bernhardt, BC, Lariviere, S, Rodriguez-Cruces, R, Royer, J, Caligiuri, ME, Gambardella, A, Concha, L, Keller, SS, Cendes, F, Yasuda, C, Bonilha, L, Gleichgerrcht, E, Focke, NK, Domin, M, von Podewills, F, Langner, S, Rummel, C, Wiest, R, Martin, P, Kotikalapudi, R, O'Brien, TJ, Sinclair, B, Vivash, L, Desmond, PM, Alhusaini, S, Doherty, CP, Cavalleri, GL, Delanty, N, Kalviainen, R, Jackson, GD, Kowalczyk, M, Mascalchi, M, Semmelroch, M, Thomas, RH, Soltanian-Zadeh, H, Davoodi-Bojd, E, Zhang, J, Lenge, M, Guerrini, R, Bartolini, E, Hamandi, K, Foley, S, Weber, B, Depondt, C, Absil, J, Carr, SJA, Abela, E, Richardson, MP, Devinsky, O, Severino, M, Striano, P, Tortora, D, Hatton, SN, Vos, SB, Duncan, JS, Whelan, CD, Thompson, PM, Sisodiya, SM, Bernasconi, A, Labate, A, McDonald, CR, Bernasconi, N, and Bernhardt, BC

Abstract

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

Published
2020

15. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

Author

Whelan, Cd, Altmann, A, Botía, Ja, Jahanshad, N, Hibar, Dp, Absil, J, Alhusaini, S, Alvim, Mkm, Auvinen, P, Bartolini, E, Bergo, Fpg, Bernardes, T, Blackmon, K, Braga, B, Caligiuri, Me, Calvo, A, Carr, Sj, Chen, J, Chen, S, Cherubini, A, David, P, Domin, M, Foley, S, França, W, Haaker, G, Isaev, D, Keller, Ss, Kotikalapudi, R, Kowalczyk, Ma, Kuzniecky, R, Langner, S, Lenge, M, Leyden, Km, Liu, M, Loi, Rq, Martin, P, Mascalchi, M, Morita, Me, Pariente, Jc, Rodríguez-Cruces, R, Rummel, C, Saavalainen, T, Semmelroch, Mk, Severino, M, Thomas, Rh, Tondelli, M, Tortora, D, Vaudano, AE39, Vivash, L40, von Podewils F42, Wagner, J43, Weber, B43, Yao, Y46, Yasuda, CL7, Zhang, G47, Bargalló, N15, Bender, B26, Bernasconi, N, Bernasconi, A, Bernhardt, Bc, Blümcke, I, Carlson, C, Cavalleri, Gl, Cendes, F, Concha, L, Delanty, N, Depondt, C, Devinsky, O, Doherty, CP51, Focke, Nk, Gambardella, A, Guerrini, R, Hamandi, K, Jackson, Gd, Kälviäinen, R, Kochunov, P, Kwan, P, Labate, A, McDonald, Cr, Meletti, S, O'Brien, Tj, Ourselin, S, Richardson MP Striano, P, Thesen, T, Wiest, R, Zhang, J, Vezzani, A, Ryten, M, Thompson, Pm, and Sisodiya, Sm.

Subjects
MRI, epilepsy, precentral gyrus, thalamus
Published
2018

16. Diabetes Mellitus tipo 2 con tendencia a la cetosis: Caso clínico

Author

Pilar Durruty A, Luciana Concha L, and Manuel García de los Ríos A

Subjects
musculoskeletal diseases, medicine.medical_specialty, Type 1 diabetes, Diabetic ketoacidosis, business.industry, Insulin, medicine.medical_treatment, Type 2 Diabetes Mellitus, Ketosis, General Medicine, Type 2 diabetes, medicine.disease, Gastroenterology, Ketoacidosis, Endocrinology, Insulin resistance, Hypoglycemic agents, Diabetes mellitus, Internal medicine, Type 2 diabetes mellitus, Medicine, business
Abstract

Ketosis prone type 2 diabetes (KPD) is presently a well-defined clinical entity, characterized by a debut with severe hyperglycemia and ketoacidosis similar to the presenting form of Type 1 diabetes mellitus (DM1). However, it appears in subjects with Type 2 diabetes mellitus (DM2) phenotype. This situation is caused by an acute, reversible dysfunction of the beta cell in individuals with insulin resistance. Once the acute stage subsides, patients behave as having a DM2 and do not require insulin treatment. They should be kept on a diet and oral hypoglycemic drugs due to their susceptibility to have recurrent acute ketotic decompensations.

Published
2015
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18. THE RETURN OF SPANISH EMIGRANTS IN EUROPE DURING THE TRANSITION TO DEMOCRACY

Author

Luis Manuel Calvo Salgado, Concha Langa Nuño, and Moisés Prieto López

Subjects
retorno de la emigración, transición a la democracia, esfera política, instituciones administrativas, medios de comunicación, History of Spain, DP1-402
Abstract

This text analyses the perception and interpretation of return during the transition to democracy in Spain, from the Spanish political spheres, from the administrative institutions in charge of managing migration policy and from the media. This multiple approach will allow us to better understand how and in what phases a new vision of the phenomenon of emigration and return was developed in this period of recent Spanish history. In order to do so, we will deal, firstly, with the political and administrative decisions that channelled the return, trying to find out to what extent they were effective, but also paying attention to the ideological and legal principles that guided them. Secondly, we will focus on the Spanish print media, which covered both this social phenomenon and the political debates it provoked. To obtain a cross-perspective, we intend to deal, on the one hand, with the written media in general and, on the other, with those specifically designed for emigrants.

Published
2022

19. Ketosis prone type 2 diabetes (KPD)

Author

Concha L, Luciana, Durruty A, Pilar, and García de los Ríos A, Manuel

Subjects
musculoskeletal diseases, Hypoglycemic agents, Type 2 diabetes mellitus, Insulin, Ketosis
Abstract

Ketosis prone type 2 diabetes (KPD) is presently a well-defined clinical entity, characterized by a debut with severe hyperglycemia and ketoacidosis similar to the presenting form of Type 1 diabetes mellitus (DM1). However, it appears in subjects with Type 2 diabetes mellitus (DM2) phenotype. This situation is caused by an acute, reversible dysfunction of the beta cell in individuals with insulin resistance. Once the acute stage subsides, patients behave as having a DM2 and do not require insulin treatment. They should be kept on a diet and oral hypoglycemic drugs due to their susceptibility to have recurrent acute ketotic decompensations.

Published
2015

20. [Ketosis prone type 2 diabetes (KPD)]

Author

Luciana, Concha L, Pilar, Durruty A, and Manuel, García de Los Ríos A

Subjects
Blood Glucose, Male, Diabetes Mellitus, Type 2, Insulin, Short-Acting, Insulin, Isophane, Humans, Middle Aged, Diabetic Ketoacidosis
Abstract

Ketosis prone type 2 diabetes (KPD) is presently a well-defined clinical entity, characterized by a debut with severe hyperglycemia and ketoacidosis similar to the presenting form of Type 1 diabetes mellitus (DM1). However, it appears in subjects with Type 2 diabetes mellitus (DM2) phenotype. This situation is caused by an acute, reversible dysfunction of the beta cell in individuals with insulin resistance. Once the acute stage subsides, patients behave as having a DM2 and do not require insulin treatment. They should be kept on a diet and oral hypoglycemic drugs due to their susceptibility to have recurrent acute ketotic decompensations.

Published
2015

21. Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation

Author

Javier Megías, Teresa San-Miguel, Mirian Sánchez, Lara Navarro, Daniel Monleón, Silvia Calabuig-Fariñas, José Manuel Morales, Lisandra Muñoz-Hidalgo, Pedro Roldán, Miguel Cerdá-Nicolás, and Concha López-Ginés

Subjects
Desmoplastic infantile astrocytoma, PTEN, BRAF V600E, Atypical, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Desmoplastic infantile astrocytoma (DIA) is rare, cystic and solid tumor of infants usually found in superficial cerebral hemispheres. Although DIA is usually benign, uncommon cases bearing malignant histological and aggressive clinical features have been described in the literature. We report a newborn patient who was diagnosed with a DIA and died postresection. Pathologic examination revealed that the main part of the tumor had benign features, but the internal region showed areas with a more aggressive appearance, with higher-proliferative cells, anaplastic GFAP positive cells with cellular polymorphism, necrosis foci, vascular hyperplasia with endothelial proliferation and microtrombosis. Genetic study, performed in both regions of the tumor, showed a BRAF V600E mutation and a homozygous deletion in PTEN, without changes in other relevant genes like EGFR, CDKN2A, TP53, NFKBIA, CDK4, MDM2 and PDGFRA. Although PTEN homozygous deletions are described in gliomas, the present case constitutes the first report of a PTEN mutation in a DIA, and this genetic feature may be related to the malignant behavior of a usually benign tumor. These genetic findings may point at the need of further and deeper genetic characterization of DIAs, in order to better understand the biology of this tumor and to obtain new prognostic approaches, a better clinical management and targeted therapies, especially in malignant cases of DIA.

Published
2022
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23. Reseñas

Author

José Manuel Nieto Soria, Ignacio Cabello Llano, Albert Cassanyes Roig, Fernando González Muñoz, Carlos M. Reglero de la Fuente, Rafael M. Girón Pascual, Juan Antonio Barrio Barrio, Pablo Sanahuja Ferrer, Fabrizio Filioli Uranio, Potito Quercia, Marina Perruca Gracia, Flavia Tudini, Raúl Molina Recio, Trilce Laske, Tibor Martí, Mercedes Gómez Oreña, Antonio González Bueno, Daniel Fernández de Miguel, Fidel Ángel Gómez Ochoa, Teresa María Ortega López, Ander Permanyer Ugartemendi, Concha Langa Nuño, Elisa Botella Rodríguez, Jorge de Hoyos Puente, and Giulia Quaggio

Subjects
Social Sciences
Published
2022

24. Intensidad de movimiento de escolares durante clases de educación física de colegios municipales: resultados según el profesional que efectúa las clases

Author

Juliana Kain B, Lorena Moreno Z, and Fernando Concha L

Subjects
educación física, estado nutricional, Nutrition and Dietetics, escolares, intensidad de movimiento, Food Science
Abstract

Las clases de educación física debieran contribuir a aumentar el gasto energético incluyendo actividades de intensidad moderada/vigorosa (AIMI) equivalentes al 50% de la clase. Se determinó el tiempo que destinan escolares a AIMI durante una clase de educación física, identificando si existen diferencias según el tipo de docente que efectúa la clase y el estado nutricional de los ninos. La muestra incluyó 549 ninos de 6-8 anos de 8 escuelas municipales. Se realizaron mediciones antropométricas y tiempo en AIMI durante una clase de educación física utilizando podómetros. La proporción de clase que correspondió a AIMI fue de 15,8% y 12,9 % en varones y ninas respectivamente, sin diferencia por estado nutricional. Si la clase fue efectuada por especialista, ésta fue 16,9% y 14,2% y por el unidocente, 13,7 % y 10,8% en varones y ninas respectivamente. Se observaron diferencias por sexo y según el tipo de profesor, pero no por estado nutricional. La proporción de AIMI en la clase de educación física es sumamente baja, muy lejos de la recomendación de que sea 50% de la clase. El curriculum escolar debiera estar enfocado hacia actividades de mayor gasto energético y en lo posible quienes estén a cargo de la asignatura sean especialistas.

Published
2012

25. Intensidad de movimiento de escolares durante clases de educación física de colegios municipales: resultados según el profesional que efectúa las clases

Author

Moreno Z, Lorena, Concha L, Fernando, and Kain B, Juliana

Subjects
educación física, nutritional status, estado nutricional, physical education, escolares, intensidad de movimiento, schoolchildren, movement intensity
Abstract

Las clases de educación física debieran contribuir a aumentar el gasto energético incluyendo actividades de intensidad moderada/vigorosa (AIMI) equivalentes al 50% de la clase. Se determinó el tiempo que destinan escolares a AIMI durante una clase de educación física, identificando si existen diferencias según el tipo de docente que efectúa la clase y el estado nutricional de los ninos. La muestra incluyó 549 ninos de 6-8 anos de 8 escuelas municipales. Se realizaron mediciones antropométricas y tiempo en AIMI durante una clase de educación física utilizando podómetros. La proporción de clase que correspondió a AIMI fue de 15,8% y 12,9 % en varones y ninas respectivamente, sin diferencia por estado nutricional. Si la clase fue efectuada por especialista, ésta fue 16,9% y 14,2% y por el unidocente, 13,7 % y 10,8% en varones y ninas respectivamente. Se observaron diferencias por sexo y según el tipo de profesor, pero no por estado nutricional. La proporción de AIMI en la clase de educación física es sumamente baja, muy lejos de la recomendación de que sea 50% de la clase. El curriculum escolar debiera estar enfocado hacia actividades de mayor gasto energético y en lo posible quienes estén a cargo de la asignatura sean especialistas. Physical education (PE) classes should contribute to increase daily energy expenditure, including moderate/ vigorous activities (MVA) during 50% ofthe class. We determined the % time in MVA during one PE class, identifying ifthere were differences according to the type of teacher in charge and the nutritional status of the children. The sample included 549 children 6 to 8 years old attending 8 public schools. Anthropometry and time in MVA were determined (usingpedometers). 15.8% and 12.9% of the PE class corresponded to MVA in boys and girls respectively, with no difference by nutritional status. If the class was taught by a PE teacher, 16.9% and 14.2% corresponded to MVA; if it was taught by the classroom teacher, it was 13.7% and 10.8% in boys and girls respectively. There were differences by sex and type of teacher, but not by nutritional status. The proportion of MVA during PE classes is much lower than the recommendation of 50% of the duration of the class. The curriculum should incorporate significantly more moderate/vigorous activities and if possible classes should be taught by PE teachers.

Published
2012

26. PCV46 COST STUDY OF CAREGIVING FOR PATIENTS WITH CHRONIC SYMPTOMATIC HEART FAILURE IN SPAIN

Author

B. Marti, J Delgado, M Llano, Molina B Diaz, Juan Oliva, J. Culebras, JJ Grillo, Nicolás Manito, J. Comin, P. Pascual, and Concha L Martínez de la

Subjects
medicine.medical_specialty, business.industry, Heart failure, Health Policy, Emergency medicine, medicine, Physical therapy, Public Health, Environmental and Occupational Health, medicine.disease, business, Cost study
Published
2010
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32. Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma

Author

Lisandra Muñoz-Hidalgo, Teresa San-Miguel, Javier Megías, Daniel Monleón, Lara Navarro, Pedro Roldán, Miguel Cerdá-Nicolás, and Concha López-Ginés

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration.In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes.Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of aggressiveness. Interestingly, accumulation of CNAs, as a measure of tumor mutational burden, was frequent and significantly associated to shortened survival. EGFR-amplified GBMs displayed both a higher number of concrete CNAs and a higher global tumor mutational burden than their no EGFR-amplified counterparts. In addition to genetic changes previously described in GBM, we found PARK2 and LARGE1 CNAs associated to EGFR amplification. The set of genes analyzed allowed us to explore relevant signaling pathways on GBM. Both PARK2 and LARGE1 are related to receptor tyrosine kinase/PI3K/PTEN/AKT/mTOR-signaling pathway. Finally, we found an association between the molecular pathways altered, EGFR amplification and a poor outcome.Our results underline the potential interest of categorizing GBM according to their EGFR amplification level and the usefulness of assessing the tumor mutational burden. These approaches would open new knowledge possibilities related to GBM biology and therapy.

Published
2020
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33. Crónicas

Author

Beatriz Martínez López, Marcela Vrzalová Hejsková, Pelayo Rubio Rodríguez, and Concha Lomba Serrano

Subjects
Arts in general, NX1-820
Published
2021

43. El estudio de las inundaciones históricas en Sevilla a través de fuentes periodísticas (siglo XX)

Author

Pilar León González-Mazón, Belén García-Martínez, and Concha Langa Nuño

Subjects
crecidas históricas, prensa escrita, llanura de inundación, Guadalquivir, Sevilla, Communication. Mass media, P87-96, Journalism. The periodical press, etc., PN4699-5650
Abstract

La relación entre Sevilla y su río ha venido marcada por las reiteradas inundaciones que ha experimentado la ciudad desde que se tienen registros históricos. El objetivo principal de este trabajo ha sido el estudio de dos de las inundaciones históricas del siglo XX de mayor envergadura (la de febrero de 1917 y la marzo de 1963) en la llanura aluvial del Guadalquivir, en dos momentos políticos diferentes (la Restauración y el Régimen Franquista) y a través de la información publicada en la prensa escrita del momento. Este estudio ha permitido la elaboración de sendas cartografías en las que se representa la extensión máxima de la lámina de agua en Sevilla; así como el análisis de la influencia política e ideológica en la manera en la que la prensa aborda las noticias sobre las inundaciones de la ciudad.

Published
2020
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44. Marisa Roësset, en la frontera (1924-1939)

Author

Concha Lomba Serrano

Subjects
marisa roësset, arte contemporáneo, pintora, moderna figuración, nuevos realismos, asuntos de género, Arts in general, NX1-820
Abstract

La misoginia que caracterizó la España del primer tercio del siglo XX y las graves dificultades que las artistas debieron sortear durante esos años definen el contexto en el que se inserta nuestra investigación, cuyo objetivo esencial es analizar la trayectoria artística de Marisa Rosset y Velasco desde que en 1924 se dio a conocer en la Exposición Nacional hasta 1939, fecha en la que concluyó la guerra civil y acabó la etapa esencial de su producción. Durante este período la artista no solo practicó una moderna figuración sino que alcanzó un elevado grado de profesionalización, hechos estos que hicieron de ella una de las pintoras de mayor calidad y más avanzadas de su época y sobre los que este trabajo centra la atención con el propósito de paliar una inmerecida laguna historiográfica.

Published
2018
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