1. Language and communication functioning in children and adolescents with agenesis of the corpus callosum.
- Author
-
Moser C, Spencer-Smith MM, Anderson PJ, McIlroy A, Wood AG, Leventer RJ, Anderson VA, and Siffredi V
- Subjects
- Humans, Adolescent, Child, Male, Female, Corpus Callosum diagnostic imaging, Corpus Callosum physiopathology, Corpus Callosum pathology, Communication, Magnetic Resonance Imaging, Language, Communication Disorders physiopathology, Communication Disorders etiology, Intelligence physiology, Agenesis of Corpus Callosum physiopathology, Agenesis of Corpus Callosum diagnostic imaging, Agenesis of Corpus Callosum complications, Agenesis of Corpus Callosum pathology
- Abstract
The corpus callosum, the largest white matter inter-hemispheric pathway, is involved in language and communication. In a cohort of 15 children and adolescents (8-15 years) with developmental absence of the corpus callosum (AgCC), this study aimed to describe language and everyday communication functioning, and explored the role of anatomical factors, social risk, and non-verbal IQ in these outcomes. Standardised measures of language and everyday communication functioning, intellectual ability and social risk were used. AgCC classification and anterior commissure volume, a potential alternative pathway, were extracted from T1-weighted images. Participants with AgCC showed reduced receptive and expressive language compared with test norms, and high rates of language and communication impairments. Complete AgCC, higher social risk and lower non-verbal IQ were associated with communication difficulties. Anterior commissure volume was not associated with language and communication. Recognising heterogeneity in language and communication functioning enhances our understanding and suggests specific focuses for potential interventions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF