149 results on '"Colquhoun, S."'
Search Results
2. Primary hepatic carcinoid tumor presenting as Cushing’s syndrome
- Author
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Shah, N. A., Urusova, I. A., D’Agnolo, A., Colquhoun, S. D., Rosenbloom, B. E., Vener, S. L., Geller, S. A., Younes, M., Lechago, J., and Heaney, A. P.
- Published
- 2007
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3. Regional variation in the surgical treatment and survival of early stage hepatocellular carcinoma in California
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Bateni, S.B., primary, Maquire, F., additional, Stewart, S.L., additional, Gangi, A., additional, Morris, C., additional, Colquhoun, S., additional, and Gholami, S., additional
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- 2020
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4. Intraoperative pulmonary embolism and intracardiac thrombosis complicating liver transplantation: a systematic review
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WARNAAR, N., MOLENAAR, I. Q., COLQUHOUN, S. D., SLOOFF, M. J. H., SHERWANI, S., de WOLF, A. M., and PORTE, R. J.
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- 2008
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5. Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent
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FIRPI, R. J., TRAN, T. T., FLORES, P., NISSEN, N., COLQUHOUN, S., SHACKLETON, C., MARTIN, P., VIERLING, J. M., and POORDAD, F. F.
- Published
- 2004
6. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
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Wang H, Bhutta Z, Coates M, Coggeshall M, Dandona L, Diallo K, Franca E, Fraser M, Fullman N, Gething P, Hay S, Kinfu Y, Kita M, Kulikoff X, Larson H, Liang J, Liang X, Lim S, Lind M, Lopez A, Lozano R, Mensah G, Mikesell J, Mokdad A, Mooney M, Naghavi M, Nguyen G, Rakovac I, Salomon J, Silpakit N, Sligar A, Sorensen R, Vos T, Zhu J, Abajobir A, Abate K, Abbas K, Abd-Allah F, Abdulle A, Abera S, Aboyans V, Abraham B, Abubakar I, Abu-Raddad L, Abu-Rmeileh N, Abyu G, Achoki T, Adebiyi A, Adedeji I, Adelekan A, Adou A, Agarwal A, Ajala O, Akinyemiju T, Akseer N, Alam K, Alam N, Alasfoor D, Aldridge R, Alegretti M, Alemu Z, Ali R, Alkerwi A, Alla F, Al-Raddadi R, Alsharif U, Altirkawi K, Martin E, Alvis-Guzman N, Amare A, Amberbir A, Amegah A, Ameh E, Ammar W, Amrock S, Andersen H, Anderson G, Antonio C, Arlov J, Artaman A, Asayesh H, Asghar R, Assadi R, Atique S, Avokpaho E, Awasthi A, Quintanilla B, Bacha U, Badawi A, Balakrishnan K, Banerjee A, Banigbe B, Barac A, Barber R, Barker-Collo S, Barnighausen T, Barrero L, Bayou T, Bayou Y, Bazargan-Hejazi S, Beardsley J, Bedi N, Bekele T, Bell M, Bello A, Bennett D, Bensenor I, Berhane A, Bernabe E, Betsu B, Beyene A, Bhatt S, Biadgilign S, Bikbov B, Birlik S, Bisanzio D, Bjertness E, Blore J, Bourne R, Brainin M, Brazinova A, Breitborde N, Brown A, Buckle G, Burch M, Butt Z, Campos-Nonato I, Campuzano J, Cardenas R, Carpenter D, Carrero J, Carter A, Casey D, Castaneda-Orjuela C, Rivas J, Castro R, Catala-Lopez F, Cercy K, Chang H, Chang J, Chibueze C, Chisumpa V, Choi J, Chowdhury R, Christopher D, Ciobanu L, Colquhoun S, Cooper C, Cornaby L, Damtew S, Danawi H, Dandona R, das Neves J, Davis A, de Jager P, De Leo D, Degenhardt L, Deribe K, Deribew A, Jarlais D, deVeber G, Dharmaratne S, Dhillon P, Ding E, Doshi P, Doyle K, Duan L, Dubey M, Ebrahimi H, Ellingsen C, Elyazar I, Endries A, Ermakov S, Eshrati B, Esteghamati A, Faraon E, Farid T, Farinha C, Faro A, Farvid M, Farzadfar F, Fereshtehnejad S, Fernandes J, Fischer F, Fitchett J, Foigt N, Franklin R, Friedman J, Furst T, Gambashidze K, Gamkrelidze A, Ganguly P, Gebre T, Gebrehiwot T, Gebremedhin A, Gebru A, Geleijnse J, Gessner B, Ginawi I, Giref A, Gishu M, Gomez-Dantes H, Gona P, Goodridge A, Gopalani S, Goto A, Gouda H, Gugnani H, Guo Y, Gupta R, Gupta V, Gyawali B, Haagsma J, Hafezi-Nejad N, Haile D, Hailu A, Hailu G, Hamadeh R, Hamidi S, Hancock J, Handal A, Hankey G, Harb H, Harikrishnan S, Harun K, Havmoeller R, Hay R, Heredia-Pi I, Hoek H, Horino M, Horita N, Hosgood H, Hotez P, Hoy D, Hsairi M, Hu G, Huang C, Huang J, Huang H, Huiart L, Huynh C, Iburg K, Idrisov B, Innos K, Jacobsen K, Jahanmehr N, Javanbakht M, Jayatilleke A, Jee S, Jeemon P, Jha V, Jiang G, Jiang Y, Jibat T, Jin Y, Jonas J, Kabir Z, Kalkonde Y, Kamal R, Kan H, Kang G, Karch A, Karema C, Kasaeian A, Kaul A, Kawakami N, Kayibanda J, Kazanjan K, Keiyoro P, Kemp A, Kengne A, Keren A, Kereselidze M, Kesavachandran C, Khader Y, Khalil I, Khan A, Khan E, Khang Y, Khonelidze I, Khubchandani J, Kim C, Kim D, Kim Y, Kissoon N, Kivipelto M, Knibbs L, Kokubo Y, Kosen S, Koul P, Koyanagi A, Defo B, Bicer B, Kudom A, Kumar G, Kutz M, Kyu H, Lal D, Lalloo R, Lam H, Lam J, Lansingh V, Larsson A, Leigh J, Leung R, Li Y, Lindsay M, Liu P, Liu S, Lloyd B, Lo W, Logroscino G, Low N, Lunevicius R, Lyons R, Ma S, Abd El Razek H, Abd El Razek M, Mahdavi M, Majdan M, Majeed A, Malekzadeh R, Mapoma C, Marcenes W, Martinez-Raga J, Marzan M, Masiye F, McGrath J, Meaney P, Mehari A, Mehndiratta M, Mekonnen A, Melaku Y, Memiah P, Memish Z, Mendoza W, Meretoja A, Meretoja T, Mhimbira F, Miller T, Mills E, Mirarefin M, Misganaw A, Mock C, Mohammad K, Mohammadi A, Mohammed S, Monasta L, Hernandez J, Montico M, Moore A, Moradi-Lakeh M, Morawska L, Mori R, Mueller U, Murphy G, Murthy S, Nachega J, Naheed A, Naidoo K, Naldi L, Nand D, Nangia V, Neupane S, Newton C, Newton J, Ng M, Ngalesoni F, Nguhiu P, Nguyen Q, Nisar M, Pete P, Norheim O, Norman R, Ogbo F, Oh I, Ojelabi F, Olivares P, Olusanya B, Olusanya J, Oren E, Ota E, Mahesh P, Park E, Park H, Parsaeian M, Caicedo A, Patten S, Pedro J, Pereira D, Perico N, Pesudovs K, Petzold M, Phillips M, Pillay J, Pishgar F, Polinder S, Pope D, Popova S, Pourmalek F, Qorbani M, Rabiee R, Rafay A, Rahimi-Movaghar V, Rahman M, Rahman S, Rai R, Raju M, Ram U, Rana S, Ranabhat C, Rao P, Refaat A, Remuzzi G, Resnikoff S, Reynolds A, Rojas-Rueda D, Ronfani L, Roshandel G, Roth G, Roy A, Ruhago G, Sagar R, Saleh M, Sanabria J, Sanchez-Nino M, Santos I, Santos J, Sarmiento-Suarez R, Sartorius B, Satpathy M, Savic M, Sawhney M, Schneider I, Schottker B, Schwebel D, Seedat S, Sepanlou S, Servan-Mori E, Setegn T, Shahraz S, Shaikh M, Shakh-Nazarova M, Sharma R, She J, Sheikhbahaei S, Shen J, Sheth K, Shibuya K, Shin H, Shin M, Shiri R, Shuie I, Sigfusdottir I, Silva D, Silverberg J, Simard E, Sindi S, Singh A, Singh J, Singh O, Singh P, Singh V, Soriano J, Soshnikov S, Sposato L, Sreeramareddy C, Stathopoulou V, Steel N, Stroumpoulis K, Sturua L, Sunguya B, Swaminathan S, Sykes B, Szoeke C, Tabares-Seisdedos R, Tavakkoli M, Taye B, Tedla B, Tefera W, Tekle T, Shifa G, Terkawi A, Tesfay F, Tessema G, Thapa K, Thomson A, Thorne-Lyman A, Tobe-Gai R, Tonelli M, Topor-Madry R, Topouzis F, Tran B, Troeger C, Truelsen T, Dimbuene Z, Tura A, Tyrovolas S, Ukwaja K, Uneke C, Uthman O, Vaezghasemi M, Vasankari T, Vasconcelos A, Venketasubramanian N, Verma R, Violante F, Vladimirov S, Vlassov V, Vollset S, Wang L, Wang Y, Weichenthal S, Weiderpass E, Weintraub R, Weiss D, Werdecker A, Westerman R, Widdowson M, Wijeratne T, Williams T, Wiysonge C, Wolfe C, Wolfe I, Won S, Wubshet M, Xiao Q, Xu G, Yadav A, Yakob B, Yano Y, Yaseri M, Ye P, Yebyo H, Yip P, Yonemoto N, Yoon S, Younis M, Yu C, Zaidi Z, Zaki M, Zeeb H, Zhang H, Zhao Y, Zheng Y, Zhou M, Zodpey S, Murray C, and GBD 2015 Child Mortality Collabora
- Published
- 2016
7. PS281 High Burden of Rheumatic Heart Disease in Maternity Services in Fiji: A National Record-Linkage Analysis
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Parks, T., primary, Narube, L., additional, Colquhoun, S., additional, Kado, J., additional, Fong, J., additional, and Steer, A., additional
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- 2016
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8. PM214 Trends in the Global Burden of Rheumatic Heart Disease During 1990-2013: Findings From the Global Burden Of Disease 2013 Study
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Watkins, D., primary, Colquhoun, S., additional, Johnson, C., additional, Carapetis, J., additional, Karthikeyan, G., additional, Naghavi, M., additional, Murray, C., additional, Vos, T., additional, and Roth, G., additional
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- 2016
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9. PS277 A Review of Patient Perceived Barriers and Enablers of Adherence to Secondary Prophylaxis Medication for Rheumatic Heart Disease in the Fiji Islands
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Colquhoun, S., primary, Read, C., additional, Ward, B., additional, Taito, R., additional, Matatolu, L., additional, Matanatabu, F., additional, Ah Kee, M., additional, La Vincente, S., additional, Kado, J., additional, and Steer, A., additional
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- 2016
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10. PM289 Towards Improved Rheumatic Heart Disease Control and Prevention in Fiji Islands
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Kennedy, E., primary, Kamunaga, M., additional, Naiceru, E., additional, Ramaka, A., additional, Matatolu, L., additional, Kado, J., additional, Jackson, C., additional, Colquhoun, S., additional, Steer, A., additional, and Wilson, N.J., additional
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- 2016
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11. PM277 Accuracy of Focused Cardiac Ultrasound Screening for Rheumatic Heart Disease by Health Workers With Limited Training
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Engelman, D., primary, Kado, J., additional, Remenyi, B., additional, Colquhoun, S., additional, Carapetis, J., additional, Donath, S., additional, Wilson, N., additional, and Steer, A., additional
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- 2016
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12. PS289 Challenges Facing Sustainability and Integration of RHD Control and Prevention Programmes in Pacific Small Island Nations
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Kennedy, E., primary, La Vincente, S., additional, Timeon, P., additional, Tiro, T., additional, Conway, N., additional, Nasi, T., additional, Kenilorea, G., additional, Engelman, D., additional, Carapetis, J., additional, and Colquhoun, S., additional
- Published
- 2016
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13. Combined Heart and Liver Transplantation: The Cedars-Sinai Experience
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Reich, H.J., primary, Awad, M., additional, Ruzza, A., additional, De Robertis, M.A., additional, Ramzy, D., additional, Nissen, N., additional, Colquhoun, S., additional, Esmailian, F., additional, Trento, A., additional, Kobashigawa, J., additional, and Czer, L.S., additional
- Published
- 2015
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14. Accuracy of focussed cardiac ultrasound screening for rheumatic heart disease by health workers with limited training
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Engelman, D., primary, Kado, J., additional, Remenyi, B., additional, Colquhoun, S., additional, Carapetis, J., additional, Wilson, N., additional, Donath, S., additional, and Steer, A., additional
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- 2015
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15. Combined Heart and Liver Transplantation in a High-Volume Transplant Center: The Cedars-Sinai Experience.
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Reich, H., primary, Awad, M., additional, Sasevich, M., additional, Nissen, N., additional, Colquhoun, S., additional, Esmailian, F., additional, Trento, A., additional, Kobashigawa, J., additional, and Czer, L., additional
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- 2014
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16. Technology-circuit convergence for full-SOC platform in 28 nm and beyond
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Arnaud, F., primary, Colquhoun, S., additional, Mareau, A.L., additional, Kohler, S., additional, Jeannot, S., additional, Hasbani, F., additional, Paulin, R., additional, Cremer, S., additional, Charbuillet, C., additional, Druais, G., additional, and Scheer, P., additional
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- 2011
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17. Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy
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Russell, F.M., primary, Licciardi, P.V., additional, Balloch, A., additional, Biaukula, V., additional, Tikoduadua, L., additional, Carapetis, J.R., additional, Nelson, J., additional, Jenney, A.W.J., additional, Waqatakirewa, L., additional, Colquhoun, S., additional, Cheung, Y.B., additional, Tang, M.L.K., additional, and Mulholland, E.K., additional
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- 2010
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18. 131. Ethnicity Correlates with Graft Failure and Overall Survival Following Liver Transplantation for Hepatocellular Carcinoma
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Artinyan, A., primary, Mailey, B.A., additional, Sanchez-Luege, N., additional, Khalili, J., additional, Colquhoun, S., additional, and Kim, J., additional
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- 2009
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19. EFFECTIVENESS OF PREOPERATIVE CHEMOEMBOLIZATION FOR HEPATOCELLULAR CARCINOMA IN LIVER TRANSPLANT CANDIDATES PRE- AND POST MODEL FOR END-STAGE LIVER DISEASE.
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Taghavi, C. E., primary, Meehan, M., additional, and Colquhoun, S. D., additional
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- 2007
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20. Predictive Delay Evaluation on Emerging CMOS Technologies: A Simulation Framework.
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Sellier, M., Portal, J.-M., Borot, B., Colquhoun, S., Ferrant, R., Boeuf, F., and Farcy, A.
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- 2008
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21. Autotransfusion: Therapeutic Principles and Trends
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Colquhoun, S. D., primary
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- 1999
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22. EXPANSION OF THE DONOR POOL BY UTILIZATION OF CADAVERIC LIVERS FROM NON-HEART BEATING DONORS
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Yersiz, H., primary, Ghobrial, R. M., additional, Farmer, D. G., additional, Amersi, F., additional, Drazan, K., additional, Chen, P., additional, Dawson, Sherfield, additional, Romani, Livio, additional, Imagawa, D., additional, Colquhoun, S., additional, Arnaout, W., additional, and Busuttil, R. W., additional
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- 1999
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23. EFFECTIVENESS OF PREOPERATIVE CHEMO-EMBOLIZATION FOR HEPATOCELLULAR CARCINOMA IN LIVER TRANSPLANT CANDIDATES
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Colquhoun, S D, primary, Ghobrial, R M, additional, Farmer, D G, additional, Goss, J A, additional, Arnaout, W S, additional, Seu, P, additional, Friedman, M, additional, Gomes, A S, additional, Hamburg, S, additional, Rosove, M H, additional, and Busuttil, R W, additional
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- 1998
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24. THE EFFECT OF IN-SITU SPLIT LIVER PROCUREMENT ON IMMEDIATE CADAVERIC ALLOGRAFT FUNCTION
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Goss, J A, primary, Seu, P, additional, Yersiz, H, additional, Imagawa, D K, additional, Colquhoun, S, additional, Drazen, K, additional, Farmer, D G, additional, Ghobrial, R M, additional, Markmann, J F, additional, McDiarmid, S V, additional, and Busuttil, R W, additional
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- 1998
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25. Retransplantation for Recurrent Hepatitis C Following Tacrolimus or Cyclosporine Immunosuppression
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Ghobrial, R.M, primary, Colquhoun, S, additional, Rosen, H, additional, Hollis, P, additional, Ponthieux, S, additional, Pakrasi, A, additional, Farmer, D.G, additional, Markman, J.F, additional, Markowitz, J, additional, Drazan, K, additional, Yersiz, H, additional, Singer, J, additional, Stribling, R, additional, Arnout, W, additional, Holt, C.D, additional, Goss, J, additional, Imagawa, D, additional, Seu, P, additional, Goldstein, L.I, additional, Shackleton, C.R, additional, Martin, P, additional, and Busuttil, R.W, additional
- Published
- 1998
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26. Metabolic activity of cultured rat brainstem, hippocampal and spinal cord slices
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Connelly, C. A., Chen, L. C., and Colquhoun, S. D.
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- 2000
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27. The Impact of Microsurgical Hepatic Arterial Reconstruction on the Outcome of Liver Transplantation for Congenital Biliary Atresia
- Author
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Shackleton, C. R., Goss, J. A., Swenson, K., Colquhoun, S. D., Seu, P., Kinkhabwala, M. M., Rudich, S. M., Markowitz, J. S., McDiarmid, S. V., and Busuttil, R. W.
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- 1997
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28. INVERSION OF THE UTERUS DUE TO SUBMUCOUS FIBROID.
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Riterband, S. H. and Colquhoun, S. P.
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- 1959
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29. Control of rheumatic heart disease in the Pacific region
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Steer, A., Colquhoun, S., Noonan, S., Kado, J., Viale, S., and Jonathan Carapetis
30. Technology-circuit convergence for full-SOC platform in 28 nm and beyond.
- Author
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Arnaud, F., Colquhoun, S., Mareau, A.L., Kohler, S., Jeannot, S., Hasbani, F., Paulin, R., Cremer, S., Charbuillet, C., Druais, G., and Scheer, P.
- Published
- 2011
- Full Text
- View/download PDF
31. THE LETTERS.
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Morrison, Darrell, Gregson, Paul, Hilton, Neil, Burrett, Brett, Vallis, Max, Evans, Len, Stoute, Roger, Dobinson, John, Rye, Owen, Williams, Alph, Nicholson, D, Watt, S, Keefer, K, Colquhoun, S, and Bennett, T
- Abstract
Several letters to the editor in response to articles in previous issues are presented, including an article on the successful rescue of miners Todd Russell and Brant Webb, an article on miners' safety, and an article on lifestyle of Australians.
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- 2006
32. SPLIT LIVER TRANSPLANTATION FOR EXPANSION OF THE DONOR POOL.
- Author
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Ghobrial, R. M., Farmer, D. G., Yersiz, H., Goss, J., Amersi, F., Drazan, Dawson, S, Chen, P, Romani, L, Imagawa, D., Colquhoun, S., Arnaout, W., Mcdiarmid, S. V., and Busuttil, R. W.
- Published
- 1999
- Full Text
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33. Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017
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Giulio Castelpietra, Feng Sha, Khalid A Altirkawi, Seyedeh Zahra Masoumi, Gebreamlak Gebremedhn Gebremeskel, Ahmad Daryani, Ibrahim Abdollahpour, Simon I. Hay, Deborah Carvalho Malta, Erin B Hamilton, Kate E. LeGrand, Nikolay Ivanovich Briko, Ana-Laura Manda, Aziz Eftekhari, Irfan Ullah, Seth Christopher Yaw Appiah, Zichen Liu, Maida Umar, Shaimaa I. El-Jaafary, Marina Pinheiro, Farhad Ghamari, Milad Mohammadoo-Khorasani, Rajaram Yadav, Syed Mohamed Aljunid, Ramesh Holla, Farzad Jalilian, Jacek Jerzy Jozwiak, Omar Mukhtar Salman, Bayew Kelkay, Tanuj Kanchan, Irina Filip, Michael R. Phillips, Hamid Reza Tohidinik, Demelash Abewa Elemineh, Reza Malekzadeh, Tomasz Miazgowski, Diana Silva, Samath D Dharmaratne, Eleonora Dubljanin, Fatemeh Zare, Jasvinder A. Singh, Hagazi Gebremedhin Kassaye, Nathaniel J Henry, Venkatesh Maled, Girikumar Kumaresh, Alireza Rafiei, Zhi-Jiang Zhang, Arielle Wilder Eagan, Merhawi Gebremedhin Tekle, Gholamreza Roshandel, Jeevan Pereira, Tinuke O Olagunju, Olatunde Aremu, Mohammad Zamani, Mu'awiyyah Babale Sufiyan, Lidia Morawska, Bayisa Abdissa Baye, Eduarda Fernandes, Feleke Mekonnen Demeke, Beriwan Abdulqadir Ali, Ibrahim A Khalil, Hafte Kahsay Kebede, Songhomitra Panda-Jonas, Yuichiro Yano, Haileab Fekadu Wolde, Antonio Maria Borzì, Delia Hendrie, Azeem Majeed, Vahid Rashedi, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Derrick A Bennett, Roba Khundkar, Mohammed Madadin, Biniyam Sahiledengle Geberemariyam, Parul Puri, Lidia Sanchez Riera, Yetunde O. John-Akinola, Jennifer Rickard, Saeed Shahabi, Tiffany K. Gill, Jemal Abdu Mohammed, Alessandra C. Goulart, Mohiuddin Ahsanul Kabir Chowdhury, Roya Safari-Faramani, Pawan Faris, Farhad Moradpour, Guilherme Borges, Sadia Bibi, Bartosz Miazgowski, Wubalem Fekadu, Rakhi Dandona, Ali Reza Soltanian, Alaa Badawi, Amir Hasanzadeh, Hassan Haghparast Bidgoli, Carlos A Castañeda-Orjuela, Morteza Arab-Zozani, Vinay Nangia, Gaurav Gupta, Farkhonde Salehi, Isabela M. Benseñor, Rekha Thapar, Yasser S. Amer, Naohiro Yonemoto, Ahmad Ghashghaee, Amanda J. Mason-Jones, Marcela Agudelo-Botero, Ashraf Nabhan, Saeed Safari, Lorainne Tudor Car, Ayman Grada, Stanislav S. Otstavnov, Keyvan Pakshir, Nefsu Awoke, Ahamarshan Jayaraman Nagarajan, Adnan Kisa, Ghasem Azarian, Yogesh Sabde, Soufiane Boufous, Fatemeh Khosravi Shadmani, Ketema Bizuwork Gebremedhin, Heather Orpana, Narayan Bahadur Mahotra, Tripti Khanna, Peter Nyasulu, Tommi Vasankari, Reza Mohammadpourhodki, Peter Njenga Keiyoro, Andrea Werdecker, Sanghamitra Pati, Rajan Nikbakhsh, Sorin Hostiuc, Prateek Rastogi, Xuefeng Liu, Manasi Kumar, Josip Car, Chuanhua Yu, Aziz Rezapour, Narayana Manjunatha, Ritesh G. Menezes, Michael K. Hole, Asadollah Gholamian, Pascual R. Valdez, Lorenzo Monasta, Amit Arora, Marek Majdan, Abraham Getachew Kelbore, Irini Chatziralli, Rafael Alves Guimarães, Mohammad Hassan Emamian, Filippo Ariani, Jeadran N. Malagón-Rojas, Jae Il Shin, Aziz Sheikh, Garumma Tolu Feyissa, Ahmed Abdelalim, Babak Moazen, Smita Pakhale, Bija Soleymani, Mehdi Hosseinzadeh, Young Eun Kim, Yunquan Zhang, Guoqing Hu, Yousef Khader, Suzanne Barker-Collo, Rizwan Suliankatchi Abdulkader, Mahdi Safdarian, Arash Sarveazad, Maria Magdalena Constantin, Dhirendra N Sinha, Alireza Ansari-Moghaddam, Khezar Hayat, Ferrán Catalá-López, Shaun Wen Huey Lee, Susan M Sawyer, Soosanna Kumary Chattu, Salman Rawaf, Seyed Sina Naghibi Irvani, Eun-Kee Park, Nauman Khalid, Marwa Rashad Salem, Duduzile Ndwandwe, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Borhan Mansouri, Faramarz Shaahmadi, Rovshan Khalilov, Milena M Santric Milicevic, Pankaj Singh, Ashish Badiye, Ai Koyanagi, Priya Rathi, Sanni Yaya, Ali Bijani, Shanshan Li, Onome Bright Oghenetega, Manoochehr Karami, Huong Lan Thi Nguyen, Soheil Hassanipour, Chukwudi A Nnaji, Obinna Onwujekwe, Swayam Prakash, Animut Tagele Tamiru, Ted R. Miller, Rebecca Ivers, Paulo A. 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I., Mokdad, A. H., Reiner, R. C., Sartorius, B., Vos, T., James, Spencer L, Castle, Chris D, Dingels, Zachary V, Fox, Jack T, Adema, Bereket Duko, Yisma, Engida, and Vos, Theo
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Dánarmein ,Fötlun ,Dánartíðni ,Lífslíkur ,Life expectancy ,1106 Human Movement and Sports Sciences ,burden of disease ,Global Health ,Global Burden of Disease ,0302 clinical medicine ,Quality-Adjusted Life Year ,Global health ,Medicine ,LIFE EXPECTANCY ,030212 general & internal medicine ,POPULATION ,Cause of death ,Original Research ,RISK ,education.field_of_study ,Global disease burdens ,Injuries ,Sjúkdómar ,Incidence (epidemiology) ,Incidence ,Population health ,Burden of disease ,Global ,global ,3142 Public health care science, environmental and occupational health ,3. Good health ,Descriptive epidemiology ,Lýðheilsa ,Quality-Adjusted Life Years ,Public Health ,TERRITORIES ,descriptive epidemiology ,Human ,Population ,195 COUNTRIES ,Humans ,Life Expectancy ,Morbidity ,Wounds and Injuries ,1117 Public Health and Health Services ,03 medical and health sciences ,AGE ,SYSTEMATIC ANALYSIS ,Mortality ,education ,Disability ,SEX-SPECIFIC MORTALITY ,business.industry ,Faraldsfræði ,DISABILITY ,Public Health, Environmental and Occupational Health ,Quality-adjusted life year ,Years of potential life lost ,Áverkar ,1701 Psychology ,Human medicine ,business ,030217 neurology & neurosurgery ,Demography - Abstract
Publisher's version (útgefin grein), Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care., Bill and Melinda Gates Foundation OPP1152504, "Peer Reviewed"
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- 2020
34. THE EFFECT OF IN-SITUSPLIT LIVER PROCUREMENT ON IMMEDIATE CADAVERIC ALLOGRAFT FUNCTION
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Goss, J A, Seu, P, Yersiz, H, Imagawa, D K, Colquhoun, S, Drazen, K, Farmer, D G, Ghobrial, R M, Markmann, J F, McDiarmid, S V, and Busuttil, R W
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- 1998
35. Awareness of rheumatic heart disease.
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Steer AC, Kado J, Colquhoun S, Noonan S, and Babitu T
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- 2006
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36. Validation of an Integrated Management of Childhood Illness algorithm for managing common skin conditions in Fiji.
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Steer AC, Tikoduadua LV, Manalac EM, Colquhoun S, Carapetis JR, and Maclennan C
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Objective To assess the sensitivity of an Integrated Management of Childhood Illness (IMCI) algorithm to detect common skin conditions in children in Fiji. Methods We collected data from the assessments of children aged between 2 months and 5 years who presented to one of two health clinics. Every child was assessed by a nurse trained in the use of the IMCI algorithm and also an expert paediatrician. We used a kappa statistic to measure agreement between the nurse/algorithm assessment method and the paediatrician's diagnosis. Findings High sensitivity for identifying skin problems (sensitivity: 98.7%; 95% confidence interval, CI: 95.5--99.9) was found for the algorithm applied by IMCI-trained nurses, who were able to identify the one child with a severe skin infection and all three children with periorbital cellulitis. Sensitivity was high for the classification of abscess/cellulitis (sensitivity: 95%; 95% CI: 75.1--99.9) and infected scabies (sensitivity: 89.1%; 95% CI: 77.8--95.9), but lower for identification of impetigo, fungal infection and, in particular, non-infected scabies. Conclusion The IMCI skin algorithm is a robust tool that should be incorporated into the IMCI after some modifications relating to scabies and impetigo. Its use by primary health-care workers will reduce the burden of skin diseases in children in Fiji through improved case identification and management. The algorithm should be considered in other countries where skin diseases in children are a priority, particularly in the Pacific region. Copyright © 2009 World Health Organization [ABSTRACT FROM AUTHOR]
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- 2009
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37. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016
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K., Brenner, Hermann, Brugha, Traolach S., Bukhman, Gene, Bulto, Lemma Negesa Bulto, Bumgarner, Blair Randal, Burch, Michael, Butt, Zahid A., Cahill, Leah E., Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael Ricardo, Car, Josip, Car, Mate, Cárdenas, Rosario, Carpenter, David O., Carrero, Juan Jesus, Carter, Austin, Castañeda-Orjuela, Carlos A., Castro, Franz F., Castro, Ruben Estanislao, Catalá-López, Ferrán, Chen, Honglei, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colquhoun, Samantha M., Coresh, Josef, Criqui, Michael H., Cromwell, Elizabeth A., Crump, John A., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, José, Davey, Gail, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, De Leo, Diego, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P., Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C., Dey, Subhojit, Dharmaratne, Samath D., Dherani, Mukesh K., Diaz-Torné, Cesar, Ding, Eric L., Dixit, Priyanka, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Donnelly, Christl Ann, dos Santos, Kadine Priscila Bender, Douwes-Schultz, Dirk, Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Dwivedi, Laxmi Kant, Ebrahimi, Hedyeh, El Bcheraoui, Charbel, Ellingsen, Christian Lycke, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshetie, Setegn, Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Fanuel, Fanuel Belayneh Bekele, Faro, André, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fernandes, João C., Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Foigt, Nataliya, Foreman, Kyle J., Frank, Tahvi, Franklin, Richard C., Fraser, Maya, Friedman, Joseph, Frostad, Joseph J., Fullman, Nancy, Fürst, Thomas, Furtado, Joao M., Futran, Neal D., Gakidou, Emmanuela, Gambashidze, Ketevan, Gamkrelidze, Amiran, Gankpé, Fortuné Gbètoho, Garcia-Basteiro, Alberto L., Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebrekidan, Kahsu Gebrekirstos, Gebremichael, Mengistu Welday, Gelaye, Amha Admasie, Geleijnse, Johanna M., Gemechu, Bikila Lencha, Gemechu, Kasiye Shiferaw, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gibney, Katherine B., Gill, Paramjit, Gillum, Richard F., Giref, Ababi Zergaw, Girma, Bedilu Weji, Giussani, Giorgia, Goenka, Shifalika, Gomez, Beatriz, Gona, Philimon N., Gopalani, Sameer Vali, Goulart, Alessandra Carvalho, Graetz, Nicholas, Gugnani, Harish Chander, Gupta, Prakash C., Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hakuzimana, Alex, Halasa, Yara A., Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W., Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Huang, Hsiang, Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M. 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Ayala Quintanilla, B, Babalola, T, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, R, Barboza, M, Barker-Collo, S, Bärnighausen, T, Barquera, S, Barregard, L, Barrero, L, Baune, B, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Béjot, Y, Bekele, B, Bell, M, Bello, A, Bennett, D, Bennett, J, Bensenor, I, Benson, J, Berhane, A, Berhe, D, Bernabé, E, Beuran, M, Beyene, A, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, Z, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, H, Bjerregaard, P, Blosser, C, Boneya, D, Boufous, S, Bourne, R, Brazinova, A, Breitborde, N, Brenner, H, Brugha, T, Bukhman, G, Bulto, L, Bumgarner, B, Burch, M, Butt, Z, Cahill, L, Cahuana-Hurtado, L, Campos-Nonato, I, Car, J, Car, M, Cárdenas, R, Carpenter, D, Carrero, J, Carter, A, Castañeda-Orjuela, C, Castillo Rivas, J, Castro, F, Castro, R, Catalá-López, F, Chen, H, Chiang, P, Chibalabala, M, Chisumpa, V, Chitheer, A, Choi, J, Christensen, H, Christopher, D, Ciobanu, L, Cirillo, M, Cohen, A, Colquhoun, S, Coresh, J, Criqui, M, Cromwell, E, Crump, J, Dandona, L, Dandona, R, Dargan, P, Das Neves, J, Davey, G, Davitoiu, D, Davletov, K, De Courten, B, De Leo, D, Degenhardt, L, Deiparine, S, Dellavalle, R, Deribe, K, Deribew, A, Des Jarlais, D, Dey, S, Dharmaratne, S, Dherani, M, Diaz-Torné, C, Ding, E, Dixit, P, Djalalinia, S, Do, H, Doku, D, Donnelly, C, Dos Santos, K, Douwes-Schultz, D, Driscoll, T, Duan, L, Dubey, M, Duncan, B, Dwivedi, L, Ebrahimi, H, El Bcheraoui, C, Ellingsen, C, Enayati, A, Endries, A, Ermakov, S, Eshetie, S, Eshrati, B, Eskandarieh, S, Esteghamati, A, Estep, K, Fanuel, F, Faro, A, Farvid, M, Farzadfar, F, Feigin, V, Fereshtehnejad, S, Fernandes, J, Feyissa, T, Filip, I, Fischer, F, Foigt, N, Foreman, K, Frank, T, Franklin, R, Fraser, M, Friedman, J, Frostad, J, Fullman, N, Fürst, T, Furtado, J, Futran, N, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gankpé, F, Garcia-Basteiro, A, Gebregergs, G, Gebrehiwot, T, Gebrekidan, K, Gebremichael, M, Gelaye, A, Geleijnse, J, Gemechu, B, Gemechu, K, Genova-Maleras, R, Gesesew, H, Gething, P, Gibney, K, Gill, P, Gillum, R, Giref, A, Girma, B, Giussani, G, Goenka, S, Gomez, B, Gona, P, Gopalani, S, Goulart, A, Graetz, N, Gugnani, H, Gupta, P, Gupta, R, Gupta, T, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hakuzimana, A, Halasa, Y, Hamadeh, R, Hambisa, M, Hamidi, S, Hammami, M, Hancock, J, Handal, A, Hankey, G, Hao, Y, Harb, H, Hareri, H, Harikrishnan, S, Haro, J, Hassanvand, M, Havmoeller, R, Hay, R, Hay, S, He, F, Heredia-Pi, I, Herteliu, C, Hilawe, E, Hoek, H, Horita, N, Hosgood, H, Hostiuc, S, Hotez, P, Hoy, D, Hsairi, M, Htet, A, Hu, G, Huang, H, Huang, J, Iburg, K, Igumbor, E, Ileanu, B, Inoue, M, Irenso, A, Irvine, C, Islam, N, Jacobsen, K, Jaenisch, T, Jahanmehr, N, Jakovljevic, M, Javanbakht, M, Jayatilleke, A, Jeemon, P, Jensen, P, Jha, V, Jin, Y, John, D, John, O, Johnson, S, Jonas, J, Jürisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, C, Karimi, S, Karthikeyan, G, Kasaeian, A, Kassaw, N, Kassebaum, N, Kastor, A, Katikireddi, S, Kaul, A, Kawakami, N, Kazanjan, K, Keiyoro, P, Kelbore, S, Kemp, A, Kengne, A, Keren, A, Kereselidze, M, Kesavachandran, C, Ketema, E, Khader, Y, Khalil, I, Khan, E, Khan, G, Khang, Y, Khera, S, Khoja, A, Khosravi, M, Kibret, G, Kieling, C, Kim, C, Kim, D, Kim, P, Kim, S, Kim, Y, Kimokoti, R, Kinfu, Y, Kishawi, S, Kissimova-Skarbek, K, Kissoon, N, Kivimaki, M, Knudsen, A, Kokubo, Y, Kopec, J, Kosen, S, Koul, P, Koyanagi, A, Kravchenko, M, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuipers, E, Kulikoff, X, Kulkarni, V, Kumar, G, Kumar, P, Kumsa, F, Kutz, M, Lachat, C, Lagat, A, Lager, A, Lal, D, Lalloo, R, Lambert, N, Lan, Q, Van Lansingh, C, Larson, H, Larsson, A, Laryea, D, Lavados, P, Laxmaiah, A, Lee, P, Leigh, J, Leung, J, Leung, R, Levi, M, Li, Y, Liao, Y, Liben, M, Lim, S, Linn, S, Lipshultz, S, Liu, S, Lodha, R, Logroscino, G, Lorch, S, Lorkowski, S, Lotufo, P, Lozano, R, Lunevicius, R, Lyons, R, Ma, S, Macarayan, E, Machado, I, Mackay, M, Magdy Abd El Razek, M, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, D, Mantovani, L, Manyazewal, T, Mapoma, C, Marczak, L, Marks, G, Martinez-Raga, J, Martins-Melo, F, Massano, J, Maulik, P, Mayosi, B, Mazidi, M, Mcalinden, C, Mcgarvey, S, Mcgrath, J, Mckee, M, Mehata, S, Mehndiratta, M, Mehta, K, Meier, T, Mekonnen, T, Meles, K, Memiah, P, Memish, Z, Mendoza, W, Mengesha, M, Mengistie, M, Mengistu, D, Menon, G, Menota, B, Mensah, G, Meretoja, A, Meretoja, T, Mezgebe, H, Micha, R, Mikesell, J, Miller, T, Mills, E, Minnig, S, Mirarefin, M, Mirrakhimov, E, Misganaw, A, Mishra, S, Mohammad, K, Mohammadi, A, Mohammed, K, Mohammed, S, Mohan, M, Mohanty, S, Mokdad, A, Molla Assaye, A, Mollenkopf, S, Molokhia, M, Monasta, L, Montañez Hernandez, J, Montico, M, Mooney, M, Moore, A, Moradi-Lakeh, M, Moraga, P, Morawska, L, Moreno Velasquez, I, Mori, R, Morrison, S, Mruts, K, Mueller, U, Mullany, E, Muller, K, Murthy, G, Murthy, S, Musa, K, Nachega, J, Nagata, C, Nagel, G, Naghavi, M, Naidoo, K, Nanda, L, Nangia, V, Nascimento, B, Natarajan, G, Negoi, I, Nguyen, C, Nguyen, G, Nguyen, Q, Nguyen, T, Ningrum, D, Nisar, M, Nomura, M, Nong, V, Norheim, O, Norrving, B, Noubiap, J, Nyakarahuka, L, Obermeyer, C, O'Donnell, M, Ogbo, F, Oh, I, Okoro, A, Oladimeji, O, Olagunju, A, Olusanya, B, Olusanya, J, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, M, Oyekale, A, Mahesh, P, Pacella, R, Pakhale, S, Pana, A, Panda, B, Panda-Jonas, S, Park, E, Parsaeian, M, Patel, T, Patten, S, Patton, G, Paudel, D, Pereira, D, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, C, Petri, W, Petzold, M, Phillips, M, Piel, F, Pigott, D, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, M, Poulton, R, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, R, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajsic, S, Ram, U, Rana, S, Ranabhat, C, Rao, P, Rawaf, S, Ray, S, Rego, M, Rehm, J, Reiner, R, Remuzzi, G, Renzaho, A, Resnikoff, S, Rezaei, S, Rezai, M, Ribeiro, A, Rokni, M, Ronfani, L, Roshandel, G, Roth, G, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, G, Saadat, S, Sabde, Y, Sachdev, P, Sadat, N, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salama, J, Salamati, P, Salomon, J, Salvi, S, Samy, A, Sanabria, J, Sanchez-Niño, M, Santos, I, Santric Milicevic, M, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, M, Schmidt, M, Schneider, I, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Seid, A, Sepanlou, S, Servan-Mori, E, Shackelford, K, Shaheen, A, Shahraz, S, Shaikh, M, Shamsipour, M, Shamsizadeh, M, Islam, S, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, B, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, M, Sigfusdottir, I, Silberberg, D, Silpakit, N, Silva, D, Silva, J, Silveira, D, Sindi, S, Singh, A, Singh, J, Singh, P, Singh, V, Sinha, D, Skiadaresi, E, Sligar, A, Smith, D, Sobaih, B, Sobngwi, E, Soneji, S, Soriano, J, Sreeramareddy, C, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, D, Steiner, C, Stöckl, H, Stokes, M, Strong, M, Sufiyan, M, Suliankatchi, R, Sunguya, B, Sur, P, Swaminathan, S, Sykes, B, Szoeke, C, Tabarés-Seisdedos, R, Tadakamadla, S, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, D, Temam Shifa, G, Temsah, M, Terkawi, A, Tesema, C, Tesssema, B, Theis, A, Thomas, N, Thompson, A, Thomson, A, Thrift, A, Tiruye, T, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, B, Truelsen, T, Trujillo, U, Tsilimparis, N, Tuem, K, Tuzcu, E, Tyrovolas, S, Ukwaja, K, Undurraga, E, Uthman, O, Uzochukwu, B, Van Boven, J, Varakin, Y, Varughese, S, Vasankari, T, Vasconcelos, A, Venketasubramanian, N, Vidavalur, R, Violante, F, Vishnu, A, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Waid, J, Wakayo, T, Wang, Y, Weichenthal, S, Weiderpass, E, Weintraub, R, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, J, Wiysonge, C, Woldeyes, B, Wolfe, C, Workicho, A, Workie, S, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, A, Yan, L, Yano, Y, Yaseri, M, Ye, P, Yimam, H, Yip, P, Yirsaw, B, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Zaidi, Z, El Sayed Zaki, M, Zeeb, H, Zenebe, Z, Zerfu, T, Zhang, A, Zhang, X, Zodpey, S, Zuhlke, L, Lopez, A, Murray, C, Erasmus MC other, Emergency Medicine, Rehabilitation Medicine, Gastroenterology & Hepatology, Public Health, and Neurology
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Dánarmein ,Heilsufar ,Dánartíðni ,Lífslíkur ,Epidemiology ,Aldurshópar ,ALCOHOL ,Börn ,Medicine and Health Sciences ,Psychology ,DEVELOPING-COUNTRIES ,Children ,Konur ,Ungbörn ,Tölfræði ,Educational status ,Aldraðir ,Medicine (all) ,Global burden of disease/statistics and numerical data ,DEATH ,Men ,Þjóðir ,Staðtölur ,Stillbirth ,Sálfræði ,World health ,SURVIVAL ,Income ,CHILD-MORTALITY ,HEALTH ,Burðarmálsdauði ,Infants ,Age distribution ,HIV infections ,Child mortality ,Alnæmi ,Menntun ,GBD ,Fæðingartíðni ,RUSSIAN MORTALITY ,Birth rate ,Life Expectancy ,SDG 3 - Good Health and Well-being ,Women ,Mortality ,METAANALYSIS ,Faraldsfræði ,HIV ,Frjósemi ,Fertility ,Socioeconomic Factors ,Karlar ,Barnadauði ,Félagshagfræði ,Tekjur ,Older people ,Cause of death/trends ,RA - Abstract
Correction in: Group Author(s): GBD 2016 Mortality Collaborators LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Sociodemographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled., Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
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- 2017
38. A pilot study using hospital surveillance and a birth cohort to investigate enteric pathogens and malnutrition in children, Dili, Timor-Leste.
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Cribb DM, Sarmento N, Moniz A, Fancourt NSS, Glass K, Draper ADK, Francis JR, Lay Dos Santos MM, Soares da Silva E, Polkinghorne BG, de Lourdes da Conceiҫão V, da Conceiҫão F, da Silva P, Jong J, Kirk MD, and Colquhoun S
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- Infant, Child, Animals, Female, Humans, Pilot Projects, Birth Cohort, Timor-Leste epidemiology, Diarrhea epidemiology, Diarrhea etiology, Hospitals, Child Nutrition Disorders epidemiology, Child Nutrition Disorders complications, Malnutrition epidemiology, Malnutrition complications, Severe Acute Malnutrition complications
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In low-to-middle-income countries (LMICs), enteric pathogens contribute to child malnutrition, affecting nutrient absorption, inducing inflammation, and causing diarrhoea. This is a substantial problem in LMICs due to high disease burden, poor sanitation and nutritional status, and the cyclical nature of pathogen infection and malnutrition. This relationship remains understudied in Timor-Leste. In our pilot study of enteric pathogens and malnutrition in Dili, Timor-Leste (July 2019-October 2020), we recruited 60 infants in a birth cohort from Hospital Nacional Guido Valadares (HNGV) with up to four home visits. We collected faecal samples and details of demographics, anthropometrics, diet and food practices, and animal husbandry. Additionally, we collected faecal samples, diagnostics, and anthropometrics from 160 children admitted to HNGV with a clinical diagnosis of severe diarrhoea or severe acute malnutrition (SAM). We tested faeces using the BioFire® FilmArray® Gastrointestinal Panel. We detected high prevalence of enteric pathogens in 68.8% (95%CI 60.4-76.2%) of infants at home, 88.6% of SAM cases (95%CI 81.7-93.3%) and 93.8% of severe diarrhoea cases (95%CI 67.7-99.7%). Diarrhoeagenic Escherichia coli and Campylobacter spp. were most frequently detected. Pathogen presence did not significantly differ in birth cohort diarrhoeal stool, but hospital data indicated associations between Salmonella and Shigella and diarrhoea. We observed wasting in 18.4% (95%CI 9.2-32.5%) to 30.8% (95%CI 17.5-47.7%) of infants across home visits, 57.9% (95%CI 34.0-78.9%) of severe diarrhoea cases, and 92.5% (95%CI 86.4-96.2%) of SAM cases. We associated bottle feeding with increased odds of pathogen detection when compared with exclusive breastfeeding at home (OR 8.3, 95%CI 1.1-62.7). We detected high prevalence of enteric pathogens and signs of malnutrition in children in Dili. Our pilot is proof of concept for a study to fully explore the risk factors and associations between enteric pathogens and malnutrition in Timor-Leste., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Cribb et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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39. Contribution of the Australian field epidemiology training workforce to the COVID-19 response, 2020.
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Parry AE, Law C, Pourmarzi D, Vogt F, Field E, and Colquhoun S
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- Humans, Australia, Public Health, Workforce, COVID-19, Epidemiology education
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Competing Interests: AP and EF are associate editors of the Western Pacific Surveillance and Response journal. They were not involved in the editorial decision to publish this manuscript.
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- 2022
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40. Leadership, politics, and communication: challenges of the epidemiology workforce during emergency response.
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Parry AE, Kirk MD, Colquhoun S, Durrheim DN, and Housen T
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- Communication, Cross-Sectional Studies, Emergencies, Female, Humans, Male, Pandemics, Politics, Workforce, COVID-19 epidemiology, Leadership
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Background: Improving the epidemiological response to emergencies requires an understanding of who the responders are, their role and skills, and the challenges they face during responses. In this paper, we explore the role of the epidemiologist and identify challenges they face during emergency response., Methods: We conducted a cross-sectional survey to learn more about epidemiologists who respond to public health emergencies. The online survey included open and closed-ended questions on challenges faced while responding, the roles of epidemiology responders, self-rating of skills, and support needed and received. We used purposive sampling to identify participants and a snowballing approach thereafter. We compared data by a number of characteristics, including national or international responder on their last response prior to the survey. We analysed the data using descriptive, content, and exploratory factor analysis., Results: We received 166 responses from individuals with experience in emergency response. The most frequently reported challenge was navigating the political dynamics of a response, which was more common for international responders than national. National responders experienced fewer challenges related to culture, language, and communication. Epidemiology responders reported a lack of response role clarity, limited knowledge sharing, and communication issues during emergency response. Sixty-seven percent of participants reported they needed support to do their job well; males who requested support were statistically more likely to receive it than females who asked., Conclusions: Our study identified that national responders have additional strengths, such as better understanding of the local political environment, language, and culture, which may in turn support identification of local needs and priorities. Although this research was conducted prior to the COVID-19 pandemic, the results are even more relevant now. This research builds on emerging evidence on how to strengthen public health emergency response and provides a platform to begin a global conversation to address operational issues and the role of the international epidemiology responder., (© 2022. The Author(s).)
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- 2022
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41. An open repository of real-time COVID-19 indicators.
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Reinhart A, Brooks L, Jahja M, Rumack A, Tang J, Agrawal S, Al Saeed W, Arnold T, Basu A, Bien J, Cabrera ÁA, Chin A, Chua EJ, Clark B, Colquhoun S, DeFries N, Farrow DC, Forlizzi J, Grabman J, Gratzl S, Green A, Haff G, Han R, Harwood K, Hu AJ, Hyde R, Hyun S, Joshi A, Kim J, Kuznetsov A, La Motte-Kerr W, Lee YJ, Lee K, Lipton ZC, Liu MX, Mackey L, Mazaitis K, McDonald DJ, McGuinness P, Narasimhan B, O'Brien MP, Oliveira NL, Patil P, Perer A, Politsch CA, Rajanala S, Rucker D, Scott C, Shah NH, Shankar V, Sharpnack J, Shemetov D, Simon N, Smith BY, Srivastava V, Tan S, Tibshirani R, Tuzhilina E, Van Nortwick AK, Ventura V, Wasserman L, Weaver B, Weiss JC, Whitman S, Williams K, Rosenfeld R, and Tibshirani RJ
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- Ambulatory Care trends, Epidemiologic Methods, Humans, Internet statistics & numerical data, Physical Distancing, Surveys and Questionnaires, Travel, United States epidemiology, COVID-19 epidemiology, Databases, Factual, Health Status Indicators
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The COVID-19 pandemic presented enormous data challenges in the United States. Policy makers, epidemiological modelers, and health researchers all require up-to-date data on the pandemic and relevant public behavior, ideally at fine spatial and temporal resolution. The COVIDcast API is our attempt to fill this need: Operational since April 2020, it provides open access to both traditional public health surveillance signals (cases, deaths, and hospitalizations) and many auxiliary indicators of COVID-19 activity, such as signals extracted from deidentified medical claims data, massive online surveys, cell phone mobility data, and internet search trends. These are available at a fine geographic resolution (mostly at the county level) and are updated daily. The COVIDcast API also tracks all revisions to historical data, allowing modelers to account for the frequent revisions and backfill that are common for many public health data sources. All of the data are available in a common format through the API and accompanying R and Python software packages. This paper describes the data sources and signals, and provides examples demonstrating that the auxiliary signals in the COVIDcast API present information relevant to tracking COVID activity, augmenting traditional public health reporting and empowering research and decision-making., Competing Interests: The authors declare no competing interest., (Copyright © 2021 the Author(s). Published by PNAS.)
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- 2021
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42. Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam.
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Hoang NA, Pham TQ, Quach HL, Nguyen KC, Colquhoun S, Lambert S, Luong DH, Tran QD, Phung DC, Duong TN, Ngu ND, Tran TA, Nguyen HBT, Dang DA, and Vogt F
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- Hospitalization, Humans, Pandemics, SARS-CoV-2, Vietnam epidemiology, COVID-19 diagnosis, COVID-19 epidemiology
- Abstract
Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases., Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance., Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6-31); it was longer in re-positive and older patients and those with pre-existing conditions., Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection., ((c) 2021 The authors; licensee World Health Organization.)
- Published
- 2021
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43. Hepatitis B in haematology patients receiving intravenous immunoglobulin: highlighting a core issue.
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Nath K, Wong T, Ahluwalia A, Colquhoun S, Clark PJ, Taylor K, and Cherian S
- Subjects
- Hepatitis B Antibodies, Hepatitis B Core Antigens, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Immunoglobulin M, Immunoglobulins, Intravenous, Hematology, Hepatitis B drug therapy, Hepatitis B epidemiology
- Published
- 2021
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44. Tuberculosis related disability: a systematic review and meta-analysis.
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Alene KA, Wangdi K, Colquhoun S, Chani K, Islam T, Rahevar K, Morishita F, Byrne A, Clark J, and Viney K
- Subjects
- Humans, Prevalence, Disabled Persons, Mental Disorders, Tuberculosis epidemiology, Tuberculosis, Multidrug-Resistant
- Abstract
Background: The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities., Methods: We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created., Results: We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively., Conclusions: TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed., Prospero Registration Number: CRD42019147488., (© 2021. The Author(s).)
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- 2021
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45. Emergency response and the need for collective competence in epidemiological teams.
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Parry AE, Kirk MD, Durrheim DN, Olowokure B, Colquhoun S, and Housen T
- Subjects
- Epidemiologists, Humans, Public Health, Workforce, Emergencies, Leadership
- Abstract
Objective: To determine the challenges met by, and needs of, the epidemiology emergency response workforce, with the aim of informing the development of a larger survey, by conducting key informant interviews of public health experts., Methods: We defined our study population as public health experts with experience of epidemiology deployment. Using purposive sampling techniques, we applied random number sampling to shortlists of potential interviewees provided by key organizations to obtain 10 study participants; we identified three additional interviewees through snowballing. The same interviewer conducted all key informant interviews during May-August 2019. We thematically analysed de-identified transcripts using a qualitative data analysis computer software package., Findings: Despite our interviewees having a wide range of organizational and field experience, common themes emerged. Interviewees reported a lack of clarity in the definition of an emergency response epidemiologist; the need for a broader range of skills; and inadequate leadership and mentoring in the field. Interviewees identified the lack of interpersonal skills (e.g. communication) and a lack of career progression options as limitations to the effectiveness of emergency response., Conclusion: The epidemiology emergency response workforce is currently not achieving collective competence. The lack of a clear definition of the role must be addressed, and leadership is required to develop teams in which complementary skills are harmonized and those less experienced can be mentored. Epidemiology bodies must consider individual professional accreditation to ensure that the required skills are being achieved, as well as enabling continual professional development., ((c) 2021 The authors; licensee World Health Organization.)
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- 2021
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46. Timeliness of contact tracing among flight passengers during the COVID-19 epidemic in Vietnam.
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Pham TQ, Hoang NA, Quach HL, Nguyen KC, Colquhoun S, Lambert S, Duong LH, Tran QD, Ha DA, Phung DC, Ngu ND, Tran TA, La QN, Nguyen TT, Le QMT, Tran DN, Vogt F, and Dang DA
- Subjects
- COVID-19 epidemiology, COVID-19 virology, Humans, SARS-CoV-2 genetics, Time Factors, Vietnam epidemiology, Air Travel statistics & numerical data, COVID-19 diagnosis, COVID-19 transmission, COVID-19 Testing, Contact Tracing, SARS-CoV-2 isolation & purification
- Abstract
Background: International air travel plays an important role in the global spread of SARS-CoV-2, and tracing of close contacts is an integral part of the public health response to COVID-19. We aimed to assess the timeliness of contact tracing among airline passengers arriving in Vietnam on flights containing COVID-19 cases and investigated factors associated with timeliness of contact tracing., Methods: We included data from 2228 passengers on 22 incoming flights between 2 and 19 March 2020. Contact tracing duration was assessed separately for the time between the date of index case confirmation and date of contact tracing initiation (interval I), and the date of contact tracing initiation and completion (interval II). We used log-rank tests and multivariable Poisson regression models to identify factors associated with timeliness., Results: The median duration of interval I and interval II was one (IQR: 1-2) and 3 days (IQR: 2-5), respectively. The contact tracing duration was shorter for passengers from flights where the index case was identified through mandatory testing directly upon arrival (median = 4; IQR: 3-5) compared to flights with index case detection through self-presentation at health facilities after arrival (median = 7; IQR: 5-8) (p-value = 0.018). Cumulative hazards for successful tracing were higher for Vietnamese nationals compared to non-Vietnamese nationals (p < 0.001)., Conclusions: Contact tracing among flight passengers in the early stage of the COVID-19 epidemic in Vietnam was timely though delays occurred on high workload days. Mandatory SARS-CoV-2 testing at arrival may reduce contact tracing duration and should be considered as an integrated screening tool for flight passengers from high-risk areas when entering low-transmission settings with limited contact tracing capacity. We recommend a standardized risk-based contact tracing approach for flight passengers during the ongoing COVID-19 epidemic.
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- 2021
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47. Hepatocellular carcinoma immunotherapy: The impact of epigenetic drugs and the gut microbiome.
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Vaziri F, Colquhoun S, and Wan YY
- Abstract
The incidence of hepatocellular carcinoma (HCC) has been increasing for decades. This disease has now risen to become the sixth most common malignancy overall, while ranking as the third most frequent cause of cancer mortality. While several surgical interventions and loco-regional treatment options are available, up to 80% of patients present with advanced disease not amenable to standard therapies. Indeed, traditional cytotoxic chemotherapeutic agents are notoriously ineffective and essentially play no role in the management of affected patients. This has led to an enormous need for more effective systemic therapeutic options. In recent years, immunotherapy has emerged as a potentially viable and exciting new alternative for the treatment of HCC. Although the current immunotherapeutic options remain imperfect, various strategies can be employed to further improve their efficacy. New findings have revealed epigenetic modulation can be effective as a new approach for improving HCC immunotherapy. Studying the gut microbiome (gut-liver axis) can also be an interesting subject in this regard. Here, we explore the latest insights into the role of immunotherapy treatmenting HCC, both mono and in combination with other agents. We also focus on the impact of epigenetic drugs and the microbiome in the overall effectiveness of HCC immunotherapy., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest.
- Published
- 2020
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48. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial.
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Thompson J, Jones N, Al-Khafaji A, Malik S, Reich D, Munoz S, MacNicholas R, Hassanein T, Teperman L, Stein L, Duarte-Rojo A, Malik R, Adhami T, Asrani S, Shah N, Gaglio P, Duddempudi A, Borg B, Jalan R, Brown R, Patton H, Satoskar R, Rossi S, Parikh A, ElSharkawy A, Mantry P, Sher L, Wolf D, Hart M, Landis C, Wigg A, Habib S, McCaughan G, Colquhoun S, Henry A, Bedard P, Landeen L, Millis M, Ashley R, Frank W, Henry A, Stange J, and Subramanian R
- Subjects
- Adult, Australia, Cell Line, Tumor, Extracorporeal Circulation adverse effects, Extracorporeal Circulation mortality, Female, Hepatitis, Alcoholic blood, Hepatitis, Alcoholic diagnosis, Hepatitis, Alcoholic mortality, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Middle Aged, Prospective Studies, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, United Kingdom, United States, Extracorporeal Circulation methods, Hepatitis, Alcoholic therapy, Hepatoblastoma metabolism, Liver Neoplasms metabolism
- Abstract
Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There is no proven effective treatment for sAH, which is why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors and were tested in an extracorporeal cellular therapy (ELAD) study to establish their effect on survival for subjects with sAH. Adults with sAH, bilirubin ≥8 mg/dL, Maddrey's discriminant function ≥ 32, and Model for End-Stage Liver Disease (MELD) score ≤ 35 were randomized to receive standard of care (SOC) only or 3-5 days of continuous ELAD treatment plus SOC. After a minimum follow-up of 91 days, overall survival (OS) was assessed by using a Kaplan-Meier survival analysis. A total of 203 subjects were enrolled (96 ELAD and 107 SOC) at 40 sites worldwide. Comparison of baseline characteristics showed no significant differences between groups and within subgroups. There was no significant difference in serious adverse events between the 2 groups. In an analysis of the intent-to-treat population, there was no difference in OS (51.0% versus 49.5%). The study failed its primary and secondary end point in a population with sAH and with a MELD ranging from 18 to 35 and no upper age limit. In the prespecified analysis of subjects with MELD < 28 (n = 120), ELAD was associated with a trend toward higher OS at 91 days (68.6% versus 53.6%; P = .08). Regression analysis identified high creatinine and international normalized ratio, but not bilirubin, as the MELD components predicting negative outcomes with ELAD. A new trial investigating a potential benefit of ELAD in younger subjects with sufficient renal function and less severe coagulopathy has been initiated. Liver Transplantation 24 380-393 2018 AASLD., (© 2017 The Authors. Liver Transplantation published by Wiley Periodicals, Inc. on behalf of American Association for the Study of Liver Diseases.)
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- 2018
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49. Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever.
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Wyber R, Boyd BJ, Colquhoun S, Currie BJ, Engel M, Kado J, Karthikeyan G, Sullivan M, Saxena A, Sheel M, Steer A, Mucumbitsi J, Zühlke L, and Carapetis J
- Subjects
- Drug Compounding, Humans, Attitude of Health Personnel, Drug Delivery Systems, Penicillin G Benzathine administration & dosage, Penicillin G Benzathine therapeutic use, Rheumatic Fever prevention & control, Secondary Prevention methods
- Abstract
Rheumatic fever is caused by an abnormal immune reaction to group A streptococcal infection. Secondary prophylaxis with antibiotics is recommended for people after their initial episode of rheumatic fever to prevent recurrent group A streptococcal infections, recurrences of rheumatic fever and progression to rheumatic heart disease. This secondary prophylaxis must be maintained for at least a decade after the last episode of rheumatic fever. Benzathine penicillin G is the first line antibiotic for secondary prophylaxis, delivered intramuscularly every 2 to 4 weeks. However, adherence to recommended secondary prophylaxis regimens is a global challenge. This paper outlines a consultation with global experts in rheumatic heart disease on the characteristics of benzathine penicillin G formulations which could be changed to improve adherence with secondary prophylaxis. Characteristics included dose interval, pain, administration mechanism, cold chain independence and cost. A sample target product profile for reformulated benzathine penicillin G is presented.
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- 2016
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50. MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A.
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Ohta K, Hoshino H, Wang J, Ono S, Iida Y, Hata K, Huang SK, Colquhoun S, and Hoon DS
- Subjects
- 3' Untranslated Regions, Adult, Aged, Aged, 80 and over, Apoptosis, Binding Sites, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular pathology, Cell Movement, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p21 genetics, Female, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Hep G2 Cells, Humans, Liver Neoplasms genetics, Liver Neoplasms pathology, Male, MicroRNAs genetics, Middle Aged, Niacinamide analogs & derivatives, Niacinamide pharmacology, PTEN Phosphohydrolase genetics, Phenylurea Compounds pharmacology, Prognosis, Protein Kinase Inhibitors pharmacology, Proto-Oncogene Proteins c-met antagonists & inhibitors, Proto-Oncogene Proteins c-met genetics, Pyrrolidinones pharmacology, Quinolines pharmacology, Sorafenib, Time Factors, Transfection, Up-Regulation, Carcinoma, Hepatocellular enzymology, Cyclin-Dependent Kinase Inhibitor p21 metabolism, Liver Neoplasms enzymology, MicroRNAs metabolism, PTEN Phosphohydrolase metabolism, Phosphatidylinositol 3-Kinase metabolism, Proto-Oncogene Proteins c-akt metabolism, Proto-Oncogene Proteins c-met metabolism
- Abstract
To assess the role of microRNAs (miR) in hepatocellular carcinoma (HCC), we performed comprehensive microRNA expression profiling using HCC cell lines and identified miR-93 as a novel target associated with HCC. We further verified miR-93 expression levels in advanced HCC tumors (n=47) by a direct PCR assay and found that elevated miR-93 expression level is significantly correlated with poor prognosis. Elevated miR-93 expression significantly stimulated in vitro cell proliferation, migration and invasion, and additionally inhibited apoptosis. We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A, respectively,and inhibited their expression. As a result of this inhibition, the c-Met/PI3K/Akt pathway activity was enhanced. IHC analysis of HCC tumors showed significant correlation between c-Met protein expression levels and miR-93 expression levels. Knockdown of c-Met inhibited the activation of the c-Met/PI3K/Akt pathway regardless of hepatocyte growth factor (HGF) treatment, and furthermore reduced the expression of miR-93 in these HCC cells. miR-93 also rendered cells to be more sensitive to sorafenib and tivantinib treatment. We concluded that miR-93 stimulated cell proliferation, migration, and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC.
- Published
- 2015
- Full Text
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