Search

Your search keyword '"Cohen, I. Kelman"' showing total 270 results
Start Over Author "Cohen, I. Kelman"
270 results on '"Cohen, I. Kelman"'

5. Commentaries on venous leg ulcers diagnostic and treatment draft guideline

Author

Sieggreen, Mary Y., Cohen, I. Kelman, Kloth, Luther C., Harding, Keith G., and Stotts, Nancy A.

Subjects
Leg -- Ulcers, Varicose ulcer -- Care and treatment, Health care industry
Abstract

University of Pennsylvania School medical researchers have drafted a guideline concerning diagnosis and treatment of venous leg ulcers. Guideline information was gathered from an interdisciplinary group of clinicians involved in wound care and reviewed by a national advisory panel. Five diagnostic modes on clinical assessment, venous disease, ankle brachial index, arterial disease, and pressure ulcers make up the diagnostic algorithm.

Published
1996

14. The Evolution of Wound Healing.

Author

Veves, Aristidis, Giurini, John M., Logerfo, Frank W., and Cohen, I. Kelman

Abstract

Man's struggle to heal wounds is as old as history itself. As life forms evolved from single cell life to amphibian and finally mammal, the pristine ability to heal by regeneration was lost and thus repairs by inflammation and subsequent deposition of matrix protein (scar) evolved as the method of mammalian healing. This evolutionary change leading to scar (the deposition of collagen) seems to be the key to preventing regeneration. It is well known that when the point is reached on the ladder where regeneration on longer occurs, inflammation and collagen deposition are the difference. In fact, if one takes a form of life, which seems the first link between regeneration and scar formation and a collagen cross-linking inhibitor is fed to the animal, then regeneration will once again occur! If we could only bridge this gap, imagine how successful we could become in the management of diabetic wounds. Although uncertain regarding why this occurred in the evolutionary process, it is hypothesized that as mammals became sophisticated, they needed rapid healing to protect themselves from other predators and to eke out a physical survival in a very hostile environment. In early-recorded history, the Egyptians repaired wounds with primitive suture materials (such as insect claws) and used clean sheets on surgical fields to prevent "suppuration."; The Greeks, led by Hippocrates, devised methods of treatment for primary wounds and chronic wounds. They used various gauze materials empirically which included wine, milk, honey, and other substances in open wounds similar to our treatment today. Today, one can assign scientific rationale to some of these ancient empirical choices. For example, the complex sugars of honey are known to suppress the growth of Gram-positive bacteria. Wine will suppress pseudomonas proliferation. Milk products may contain cytokines or serve as buffers to control wound pH. Although the ancients had no idea that pus was actually is made up of proteins and dead leukocytes, they understood that drainage of localized products of infection was a good sign (laudable pus). They understood that when signs opf inflammation could not be localized that death would inevitably follow. During the early Roman era, Celsius, unaware of the existence of bacteria, did recognize and describe the cardinal signs of clinical infection being (1) rubor—erythema, (2) tumor—swelling, (3) dolor—pain, and (4) calor—heat. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

15. RESEARCH AND DEVELOPMENT OF ACTIVE COTTON WOUND DRESSINGS FOR CHRONIC WOUND HEALING.

Author

Edwards, J. Vincent, Dome, Alvin Bopp, Yachmenev, Valeriy, Yager, R., Cohen, I. Kelman, and Diegelmann, Robert F.

Abstract

The research and development of cotton-based wound dressings based on a molecular mechanism of action for development of an active chronic wound dressing is presented. The research prototype for sequestration of destructive protease from chronic wound fluid is based on a peptide conjugate of cellulose consisting of an enzyme active site recognition sequence (Val--Pro--Val that possesses affinity for the active site of human neutrophil elastase. This prototype cellulose conjugate demonstrated elastase lowering activity, and prompted development of a cotton-based dressing that was constructed with molecular design of the fiber using aqueous finishing techniques that can be economically adapted for the textile mill production of the active wound dressing. During the course of the development of the dressing issues concerning the selective activity of the dressing in the presence of the wound proteins prompted alternative design considerations. This report constitutes an update on the progress towards commercialization of the active wound dressings. [ABSTRACT FROM AUTHOR]

Published
2004

16. DESIGN, PREPARATION, AND ACTIVITY OF COTTON-BASED WOUND DRESSINGS FOR CHRONIC WOUNDS.

Author

Edwards, J. Vincent, Bopp, Alvin, Yager, Dome R., Cohen, I. Kelman, and Diegelmann, Robert F.

Abstract

Chronic wounds are a major worldwide health problem. Cotton gauze is a standard of care in the management of chronic wounds and is still routinely employed in hospitals and nursing homes for long term wound care. We consider in this paper molecular modifications of cotton gauze to improve chronic wound healing. The presence of elevated levels of elastase in non-healing wounds has been associated with the degradation of important growth factors and fibronectin necessary for wound healing. In the healing wound a balance of elastase and antiproteases prevents this degradation from taking place. Cotton cellulose modified to release elastase inhibitors or selectively sequester elastase would provide a gauze wound dressing that decreases high levels of destructive elastase found in the chronic wound. [ABSTRACT FROM AUTHOR]

Published
2003

37. Wound Healing

Author

Cohen, I. Kelman, primary, Die-gelmann, Robert F., additional, Lindblad, William J., additional, and Hugo, Norman E., additional

Published
1992
Full Text
View/download PDF

44. Fetal Skin Organ Culture

Author

Haynes, Jeffrey H., primary, Krummel, Thomas M., additional, Flood, Louise C., additional, Cohen, I. Kelman, additional, and Diegelmann, Robert F., additional

Published
1990
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results