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2. Outcomes of Decompressive Surgery for Patients With Severe Cerebral Venous Thrombosis: DECOMPRESS2 Observational Study

Author

Aaron, Sanjit, Ferreira, Jorge M., Coutinho, Jonathan M., Canhão, Patrícia, Conforto, Adriana B., Arauz, Antonio, Carvalho, Marta, Masjuan, Jaime, Sharma, Vijay K., Putaala, Jukka, Uyttenboogaart, Maarten, Werring, David J., Bazan, Rodrigo, Mohindra, Sandeep, Weber, Jochen, Coert, Bert A., Kirubakaran, Prabhu, Sanchez van Kammen, Mayte, Singh, Pankaj, Aguiar de Sousa, Diana, Ferro, José M., Benjamin, Kenneth, Zuurbier, Yvonne, Winckler, Fernanda, MFerro, José, Costa, Marisa, Barboza, Miguel, Uribe Pacheco, Rodrigo, Alvis, Fernando, Serrano, Eunice, Menendez, Fernanda, Soriano Navarro, Eduardo, Wilson, Duncan, Vida, Mariann, and Greiner, Karolin

Published
2024
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8. Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage: Post Hoc Analysis of the ULTRA Trial

Author

Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korné, Koot, Radboud W., Kruyt, Nyika D., Willems, Peter W.A., Wolfs, Jasper F.C., de Beer, Frits C., Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H.A., Reichman, Loes J.A., Brouwers, Paul J.A.M., Van den Berg-Vos, Renske M., Kwa, Vincent I.H., van der Ree, Taco C., Bronner, Irene, Bienfait, Henri P., Boogaarts, Hieronymus, Klijn, Catharina J.M., van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.M., Vandertop, W. Peter, and Verbaan, Dagmar

Published
2022
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9. Ultra-Early and Short-Term Tranexamic Acid Treatment in Patients With Good- and Poor-Grade Aneurysmal Subarachnoid Hemorrhage

Author

Neurologen, Brain, Circulatory Health, Projectafdeling CVZ, Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korne, Koot, Radboud W., Kruyt, Nyika D., Wolfs, Jasper F.C., De Beer, Frits C., Kieft, Hans H., Nanda, Dharmin, Van Der Pol, Bram, Roks, Gerwin, De Beer, Frank, Reichman, Loes J.A., Brouwers, Paul J.A.M., Kwa, Vincent I.H., Van Der Ree, Taco C., Bienfait, Henri P., Boogaarts, Hieronymus D., Klijn, Catharina J., Visser, Victoria, van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., Vandertop, W. Peter, Verbaan, Dagmar, ULTRA trial study group, Neurologen, Brain, Circulatory Health, Projectafdeling CVZ, Tjerkstra, Maud A., Post, René, Germans, Menno R., Vergouwen, Mervyn D.I., Jellema, Korne, Koot, Radboud W., Kruyt, Nyika D., Wolfs, Jasper F.C., De Beer, Frits C., Kieft, Hans H., Nanda, Dharmin, Van Der Pol, Bram, Roks, Gerwin, De Beer, Frank, Reichman, Loes J.A., Brouwers, Paul J.A.M., Kwa, Vincent I.H., Van Der Ree, Taco C., Bienfait, Henri P., Boogaarts, Hieronymus D., Klijn, Catharina J., Visser, Victoria, van den Berg, René, Coert, Bert A., Horn, Janneke, Majoie, Charles B.L.M., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., Vandertop, W. Peter, Verbaan, Dagmar, and ULTRA trial study group

Published
2024

10. Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage

Author

Neurologen, Brain, Circulatory Health, UMC Utrecht, Germans, Menno R., Tjerkstra, Maud A., Post, René, Brenner, Amy, Vergouwen, Mervyn D.I., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., van den Berg, René, Coert, Bert A., Vandertop, W. Peter, Verbaan, Dagmar, Neurologen, Brain, Circulatory Health, UMC Utrecht, Germans, Menno R., Tjerkstra, Maud A., Post, René, Brenner, Amy, Vergouwen, Mervyn D.I., Rinkel, Gabriël J.E., Roos, Yvo B.W.E.M., van den Berg, René, Coert, Bert A., Vandertop, W. Peter, and Verbaan, Dagmar

Published
2024

11. Impact of time to start of tranexamic acid treatment on rebleed risk and outcome in aneurysmal subarachnoid hemorrhage

Author

Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Brenner, Amy, Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Rinkel, Gabriël Je, Roos, Yvo Bwem; https://orcid.org/0000-0001-9205-5882, van den Berg, René, Coert, Bert A, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Brenner, Amy, Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Rinkel, Gabriël Je, Roos, Yvo Bwem; https://orcid.org/0000-0001-9205-5882, van den Berg, René, Coert, Bert A, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, and Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470

Abstract

INTRODUCTION: The ULTRA-trial investigated effectiveness of ultra-early administration of tranexamic acid (TXA) in subarachnoid hemorrhage (SAH) and showed that TXA reduces the risk of rebleeding without concurrent improvement in clinical outcome. Previous trials in bleeding conditions, distinct from SAH, have shown that time to start of antifibrinolytic treatment influences outcome. This post-hoc analysis of the ULTRA-trial investigates whether the interval between hemorrhage and start of TXA impacts the effect of TXA on rebleeding and functional outcome following aneurysmal SAH. PATIENTS AND METHODS: A post-hoc comparative analysis was conducted between aneurysmal SAH patients of the ULTRA-trial, receiving TXA and usual care to those receiving usual care only. We assessed confounders, hazard ratio (HR) of rebleeding and odds ratio (OR) of good outcome (modified Rankin Scale 0-3) at 6 months, and investigated the impact of time between hemorrhage and start of TXA on the treatment effect, stratified into time categories (0-3, 3-6 and >6 h). RESULTS: Sixty-four of 394 patients (16.2%) in the TXA group experienced a rebleeding, compared to 83 of 413 patients (19.9%) with usual care only (HR 0.86, 95% confidence interval (CI): 0.62-1.19). Time to start of TXA modifies the effect of TXA on rebleeding rate (p < 0.001), with a clinically non-relevant reduction observed only when TXA was initiated after 6 h (absolute rate reduction 1.4%). Tranexamic acid treatment showed no effect on good outcome (OR 0.96, 95% CI: 0.72-1.27) with no evidence of effect modification on the time to start of TXA (p = 0.53). DISCUSSION AND CONCLUSIONS: This study suggests that the effect of TXA on rebleeding is modified by time to treatment, providing a protective, albeit clinically non-relevant, effect only when started after 6 h. No difference in functional outcome was seen. Routine TXA treatment in the aneurysmal SAH population, even within a specified time frame, is not recommended to impro

Published
2024

12. Ultra-Early and Short-Term Tranexamic Acid Treatment in Patients With Good- and Poor-Grade Aneurysmal Subarachnoid Hemorrhage

Author

Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Vergouwen, Mervyn D I; https://orcid.org/0000-0002-6823-1628, Jellema, Korne, Koot, Radboud W, Kruyt, Nyika D; https://orcid.org/0000-0002-2320-0932, Wolfs, Jasper F C, De Beer, Frits C; https://orcid.org/0000-0003-4725-7156, Kieft, Hans H; https://orcid.org/0000-0003-2083-710X, Nanda, Dharmin, Van Der Pol, Bram; https://orcid.org/0000-0001-5173-9989, Roks, Gerwin; https://orcid.org/0000-0002-1393-9848, De Beer, Frank, Reichman, Loes J A, Brouwers, Paul J A M, Kwa, Vincent I H; https://orcid.org/0000-0002-0942-6206, Van Der Ree, Taco C, Bienfait, Henri P; https://orcid.org/0000-0002-5698-0031, Boogaarts, Hieronymus D; https://orcid.org/0000-0001-5855-2447, Klijn, Catharina J; https://orcid.org/0000-0002-8495-4578, Visser, Victoria, van den Berg, René, Coert, Bert A, Horn, Janneke; https://orcid.org/0000-0002-3788-7675, Majoie, Charles B L M; https://orcid.org/0000-0002-7600-9568, Rinkel, Gabriël J E, Roos, Yvo B W E M; https://orcid.org/0000-0001-9205-5882, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470, Tjerkstra, Maud A; https://orcid.org/0000-0001-9060-3435, Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Vergouwen, Mervyn D I; https://orcid.org/0000-0002-6823-1628, Jellema, Korne, Koot, Radboud W, Kruyt, Nyika D; https://orcid.org/0000-0002-2320-0932, Wolfs, Jasper F C, De Beer, Frits C; https://orcid.org/0000-0003-4725-7156, Kieft, Hans H; https://orcid.org/0000-0003-2083-710X, Nanda, Dharmin, Van Der Pol, Bram; https://orcid.org/0000-0001-5173-9989, Roks, Gerwin; https://orcid.org/0000-0002-1393-9848, De Beer, Frank, Reichman, Loes J A, Brouwers, Paul J A M, Kwa, Vincent I H; https://orcid.org/0000-0002-0942-6206, Van Der Ree, Taco C, Bienfait, Henri P; https://orcid.org/0000-0002-5698-0031, Boogaarts, Hieronymus D; https://orcid.org/0000-0001-5855-2447, Klijn, Catharina J; https://orcid.org/0000-0002-8495-4578, Visser, Victoria, van den Berg, René, Coert, Bert A, Horn, Janneke; https://orcid.org/0000-0002-3788-7675, Majoie, Charles B L M; https://orcid.org/0000-0002-7600-9568, Rinkel, Gabriël J E, Roos, Yvo B W E M; https://orcid.org/0000-0001-9205-5882, Vandertop, W Peter; https://orcid.org/0000-0001-5417-0265, and Verbaan, Dagmar; https://orcid.org/0000-0002-9212-5470

Abstract

The results of the ULTRA trial showed that ultra-early and short-term treatment with tranexamic acid (TXA) does not improve clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Possibly, the lack of a beneficial effect in all patients with aSAH is masked by antagonistic effects of TXA in certain subgroups. In this post hoc subgroup analysis, we investigated the effect of TXA on clinical outcome in patients with good-grade and poor-grade aSAH.

Published
2024

24. Clinical Response following Hypertension‐Induction for clinical Delayed Cerebral Ischemia following Subarachnoid Haemorrhage – a retrospective multicentre cohort study

Author

Tjerkstra, Maud A., primary, Müller, Marcella C. A., additional, Coert, Bert. A., additional, Hoefnagels, Friso W. A., additional, Vergouwen, Mervyn D. I., additional, van Vliet, Peter, additional, Ooms, Lizzy, additional, Rinkel, Gabriël J. E., additional, Slooter, Arjen J. C., additional, Moojen, Wouter A., additional, Jellema, Korné, additional, Vandertop, W. Peter, additional, and Verbaan, Dagmar, additional

Published
2023
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27. Aneurysm treatment within 6 h versus 6–24 h after rupture in patients with subarachnoid hemorrhage

Author

Neurologen, Brain, Circulatory Health, Vergouwen, Mervyn D.I., Germans, Menno R., Post, René, Tjerkstra, Maud A., Coert, Bert A., Rinkel, Gabriel J.E., Peter Vandertop, William, Verbaan, Dagmar, Neurologen, Brain, Circulatory Health, Vergouwen, Mervyn D.I., Germans, Menno R., Post, René, Tjerkstra, Maud A., Coert, Bert A., Rinkel, Gabriel J.E., Peter Vandertop, William, and Verbaan, Dagmar

Published
2023

28. Clinical response following hypertension induction for clinical delayed cerebral ischemia following subarachnoid hemorrhage: A retrospective, multicenter, cohort study

Author

Neurochirurgen, Neurologen, Brain, Circulatory Health, AIOS Psychiatrie, Tjerkstra, Maud A, Müller, Marcella C A, Coert, Bert A, Hoefnagels, Friso W A, Vergouwen, Mervyn D I, van Vliet, Peter, Ooms, Lizzy, Rinkel, Gabriël J E, Slooter, Arjen J C, Moojen, Wouter A, Jellema, Korné, Vandertop, W Peter, Verbaan, Dagmar, Neurochirurgen, Neurologen, Brain, Circulatory Health, AIOS Psychiatrie, Tjerkstra, Maud A, Müller, Marcella C A, Coert, Bert A, Hoefnagels, Friso W A, Vergouwen, Mervyn D I, van Vliet, Peter, Ooms, Lizzy, Rinkel, Gabriël J E, Slooter, Arjen J C, Moojen, Wouter A, Jellema, Korné, Vandertop, W Peter, and Verbaan, Dagmar

Published
2023

29. Aneurysm treatment within 6 h versus 6-24 h after rupture in patients with subarachnoid hemorrhage

Author

Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Germans, Menno R, Post, René, Tjerkstra, Maud A, Coert, Bert A, Rinkel, Gabriel Je, Peter Vandertop, William, Verbaan, Dagmar, Vergouwen, Mervyn DI; https://orcid.org/0000-0002-6823-1628, Germans, Menno R, Post, René, Tjerkstra, Maud A, Coert, Bert A, Rinkel, Gabriel Je, Peter Vandertop, William, and Verbaan, Dagmar

Abstract

BACKGROUND The risk of rebleeding after aneurysmal subarachnoid hemorrhage (aSAH) is the highest during the initial hours after rupture. Emergency aneurysm treatment may decrease this risk, but is a logistic challenge and economic burden. We aimed to investigate whether aneurysm treatment <6 h after rupture is associated with a decreased risk of poor functional outcome compared to aneurysm treatment 6-24 h after rupture. METHODS We used data of patients included in the ULTRA trial (NCT02684812). All patients in ULTRA were admitted within 24 h after aneurysm rupture. For the current study, we excluded patients in whom the aneurysm was not treated <24 h after rupture. We calculated crude and adjusted risk ratios (aRR) with 95% confidence intervals using Poisson regression analyses for poor functional outcome (death or dependency, assessed by the modified Rankin Scale) after aneurysm treatment <6 h versus 6-24 h after rupture. Adjustments were made for age, sex, clinical condition on admission (WFNS scale), amount of extravasated blood (Fisher score), aneurysm location, tranexamic acid treatment, and aneurysm treatment modality. RESULTS We included 497 patients. Poor outcome occurred in 63/110 (57%) patients treated within 6 h compared to 145/387 (37%) patients treated 6-24 h after rupture (crude RR: 1.53, 95% CI: 1.24-1.88; adjusted RR: 1.36, 95% CI: 1.11-1.66). CONCLUSION Aneurysm treatment <6 h is not associated with better functional outcome than aneurysm treatment 6-24 h after rupture. Our results do not support a strategy aiming to treat every patient with a ruptured aneurysm <6 h after rupture.

Published
2023

30. Laboratory biomarkers of delayed cerebral ischemia following subarachnoid hemorrhage: A systematic review

Author

Tjerkstra, Maud, Labib, Homeyra, Coert, Bert A., Spijker, René, Coutinho, Jonathan M., Vandertop, W. Peter, Verbaan, Dagmar, Tjerkstra, Maud, Labib, Homeyra, Coert, Bert A., Spijker, René, Coutinho, Jonathan M., Vandertop, W. Peter, and Verbaan, Dagmar

Abstract

Delayed cerebral ischemia (DCI) substantially contributes to disability and death in subarachnoid hemorrhage (SAH) patients; however, its pathophysiology is incompletely understood and diagnostic and therapeutic strategies are lacking. Biomarkers may help to elucidate the pathophysiology, optimize early diagnosis, or provide treatment targets. We systematically searched PubMed and Embase on October 13, 2021, for studies that evaluated at least one laboratory biomarker in patients with DCI, using the most up-to-date definition of DCI as proposed by a panel of experts in 2010. Quality of studies was assessed using the Newcastle-Ottawa Scale or Cochrane Collaboration’s risk of bias assessment tool. Biomarkers of clinical and radiological DCI were analyzed separately. Results were meta-analyzed if possible, otherwise narratively reviewed. Biomarkers were classified as significant, inconclusive, or nonsignificant. We defined validated biomarkers as those with significant results in meta-analyses, or in at least two studies using similar methodologies within the same time interval after SAH. The search yielded 209 articles with 724 different biomarkers; 166 studies evaluated 646 biomarkers of clinical DCI, of which 141 were significant and 7 were validated biomarkers (haptoglobulin 2-1 and 2-2, ADAMTS13, vWF, NLR, P-selectin, F2-isoprostane); 78 studies evaluated 165 biomarkers of radiological DCI, of which 63 were significant and 1 was a validated biomarker (LPR). Hence, this review provides a selection of seven biomarkers of clinical DCI and one biomarker of radiological DCI as most promising biomarkers of DCI. Future research should focus on determining the exact predictive, diagnostic, and therapeutic potentials of these biomarkers.

Published
2023

32. Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Author

Gathier, Celine S., primary, Zijlstra, IJsbrand A.J., additional, Rinkel, Gabriel J.E., additional, Groenhof, T. Katrien J., additional, Verbaan, Dagmar, additional, Coert, Bert A., additional, Müller, Marcella C.A., additional, van den Bergh, Walter M., additional, Slooter, Arjen J.C., additional, and Eijkemans, Marinus J.C., additional

Published
2022
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33. Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial

Author

Gathier, Celine S., van den Bergh, Walter M., van der Jagt, Mathieu, Verweij, Bon H., Dankbaar, Jan Willem, Müller, Marcella C., Oldenbeuving, Annemarie W., Rinkel, Gabriel J.E., Slooter, Arjen J.C., Algra, Ale, Kesecioglu, Jozef, van der Schaaf, Irene C., Dammers, Ruben, Dippel, Diederik W.J., Dirven, Clemens M.F., van Kooten, Fop, van der Lugt, Aad, Coert, Bert A., Horn, Janneke, Vandertop, W. Peter, Beute, Gus N., van der Pol, Bram, Roks, Gerwin, van Rooij, Willem Jan J., and Sluzewski, Menno

Published
2018
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34. Prehemorrhage antiplatelet use in aneurysmal subarachnoid hemorrhage and impact on clinical outcome

Author

Sebök, Martina; https://orcid.org/0000-0002-7246-3421, Hostettler, Isabel C; https://orcid.org/0000-0002-9004-2540, Keller, Emanuela; https://orcid.org/0000-0002-7560-7574, Rautalin, Ilari M; https://orcid.org/0000-0002-6283-0398, Coert, Bert A, Vandertop, William P; https://orcid.org/0000-0001-5417-0265, Post, René; https://orcid.org/0000-0001-7844-6262, Sardeha, Ali, Tjerkstra, Maud A, Regli, Luca, Verbaan, Dagmar, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Sebök, Martina; https://orcid.org/0000-0002-7246-3421, Hostettler, Isabel C; https://orcid.org/0000-0002-9004-2540, Keller, Emanuela; https://orcid.org/0000-0002-7560-7574, Rautalin, Ilari M; https://orcid.org/0000-0002-6283-0398, Coert, Bert A, Vandertop, William P; https://orcid.org/0000-0001-5417-0265, Post, René; https://orcid.org/0000-0001-7844-6262, Sardeha, Ali, Tjerkstra, Maud A, Regli, Luca, Verbaan, Dagmar, and Germans, Menno R; https://orcid.org/0000-0003-2185-4526

Abstract

BACKGROUND: Literature is inconclusive regarding the association between antiplatelet agents use and outcome after aneurysmal subarachnoid hemorrhage. AIMS: To investigate the association between clinical outcome and prehemorrhage use in aneurysmal subarachnoid hemorrhage patients as well as the impact of thrombocyte transfusion on rebleed and clinical outcome. METHODS: Data were collected from prospective databases of two European tertiary reference centers for aneurysmal subarachnoid hemorrhage patients. Patients were divided into "antiplatelet-user" and "non-user" according to the use of acetylsalicylic acid prior to the hemorrhage. Primary outcome was poor clinical outcome at six months (Glasgow Outcome Scale score 1-3). Secondary outcomes were in-hospital mortality and impact of thrombocyte transfusion. RESULTS: Of the 1033 patients, 161 (15.6%) were antiplatelet users. The antiplatelet users were older with higher incidence of cardiovascular risk factors. Antiplatelet use was associated with poor outcome and in-hospital mortality. After correction for age, sex, World Federation of Neurosurgical Societies score, infarction and heart disorder, pre-hemorrhage acetylsalicylic acid use was only associated with poor clinical outcome at six months (adjusted OR 1.80, 95% CI 1.08-3.02). Thrombocyte transfusion was not associated with a reduction in rebleed or poor clinical outcome. CONCLUSION: In this multicenter study, the prehemorrhage acetylsalicylic acid use in aneurysmal subarachnoid hemorrhage patients was independently associated with poor clinical outcome at six months. Thrombocyte transfusion was not associated with the rebleed rate or poor clinical outcome at six months.

Published
2022

35. Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage: Post-Hoc Analysis of the ULTRA Trial

Author

Neurologen, Brain, Circulatory Health, Neurochirurgen, Tjerkstra, Maud A, Post, Rene, Germans, Menno R, Vergouwen, Mervyn D I, Jellema, Korné, Koot, Radboud W, Kruyt, Nyika D, Willems, Peter W A, Wolfs, Jasper F C, de Beer, Frits C, Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H A, Reichman, Loes J A, Brouwers, Paul J A M, Van den Berg-Vos, Renske M, Kwa, Vincent I H, van der Ree, Taco C, Bronner, Irene, Bienfait, Henri P, Boogaarts, Hieronymus, Klijn, Catharina Jm, van den Berg, René, Coert, Bert A, Horn, Janneke, Majoie, Charles B L M, Rinkel, Gabriël J E, Roos, Yvo B W M, Vandertop, William, Verbaan, Dagmar, Neurologen, Brain, Circulatory Health, Neurochirurgen, Tjerkstra, Maud A, Post, Rene, Germans, Menno R, Vergouwen, Mervyn D I, Jellema, Korné, Koot, Radboud W, Kruyt, Nyika D, Willems, Peter W A, Wolfs, Jasper F C, de Beer, Frits C, Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H A, Reichman, Loes J A, Brouwers, Paul J A M, Van den Berg-Vos, Renske M, Kwa, Vincent I H, van der Ree, Taco C, Bronner, Irene, Bienfait, Henri P, Boogaarts, Hieronymus, Klijn, Catharina Jm, van den Berg, René, Coert, Bert A, Horn, Janneke, Majoie, Charles B L M, Rinkel, Gabriël J E, Roos, Yvo B W M, Vandertop, William, and Verbaan, Dagmar

Published
2022

36. Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Author

Opleiding Neurologie, Neurologen, Brain, Circulatory Health, Cardiovasculaire Epi Team 5, Divisie Vitale Functies, AIOS Psychiatrie, Medische Staf Intensive Care, Biostatistiek Onderzoek, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gathier, Celine S, Zijlstra, IJsbrand A J, Rinkel, Gabriel J E, Groenhof, T Katrien J, Verbaan, Dagmar, Coert, Bert A, Müller, Marcella C A, van den Bergh, Walter M, Slooter, Arjen J C, Eijkemans, Marinus J C, Opleiding Neurologie, Neurologen, Brain, Circulatory Health, Cardiovasculaire Epi Team 5, Divisie Vitale Functies, AIOS Psychiatrie, Medische Staf Intensive Care, Biostatistiek Onderzoek, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gathier, Celine S, Zijlstra, IJsbrand A J, Rinkel, Gabriel J E, Groenhof, T Katrien J, Verbaan, Dagmar, Coert, Bert A, Müller, Marcella C A, van den Bergh, Walter M, Slooter, Arjen J C, and Eijkemans, Marinus J C

Published
2022

37. Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine

Author

Neurologen, Brain, Circulatory Health, van Os, Hendrikus J A, Verbaan, Dagmar, Ruigrok, Ynte M, Dennesen, Paul, Müller, Marcella C A, Coert, Bert A, Vergouwen, Mervyn D I, Wermer, Marieke J H, Neurologen, Brain, Circulatory Health, van Os, Hendrikus J A, Verbaan, Dagmar, Ruigrok, Ynte M, Dennesen, Paul, Müller, Marcella C A, Coert, Bert A, Vergouwen, Mervyn D I, and Wermer, Marieke J H

Published
2022

38. Deferred Consent in an Acute Stroke Trial from a Patient, Proxy, and Physician Perspective: A Cross-Sectional Survey

Author

Projectafdeling CVZ, Bioethics & Health Humanities, JC onderzoeksprogramma Methodologie, Circulatory Health, Opleiding Neurologie, Neurologen, Brain, Koopman, Inez, Verbaan, Dagmar, Vandertop, W Peter, van der Graaf, Rieke, Kompanje, Erwin J O, Post, René, Coert, Bert A, Ploem, Martine C, Sluis, Wouter M, Scheijmans, Féline E V, Rinkel, Gabriel J E, Vergouwen, Mervyn D I, Projectafdeling CVZ, Bioethics & Health Humanities, JC onderzoeksprogramma Methodologie, Circulatory Health, Opleiding Neurologie, Neurologen, Brain, Koopman, Inez, Verbaan, Dagmar, Vandertop, W Peter, van der Graaf, Rieke, Kompanje, Erwin J O, Post, René, Coert, Bert A, Ploem, Martine C, Sluis, Wouter M, Scheijmans, Féline E V, Rinkel, Gabriel J E, and Vergouwen, Mervyn D I

Published
2022

39. Interventions in Acute Intracranial Surgery: An Evidence-Based Perspective

Author

Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Buis, Dennis R, Coert, Bert A, Vandertop, W Peter, Verbaan, Dagmar, Post, René; https://orcid.org/0000-0001-7844-6262, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Buis, Dennis R, Coert, Bert A, Vandertop, W Peter, and Verbaan, Dagmar

Abstract

From a pathophysiological point of view, early neurosurgical treatment seems essential to prevent secondary brain injury and has been stated as the "time-is-brain" concept. However, the question immediately rises: "Is there an optimal time window for acute intracranial neurosurgical interventions?" In neurosurgery, treatment modality has been studied far more extensively than timing to surgery ("time-to-surgery"). The majority of acute intracranial neurosurgical interventions are carried out for traumatic brain injury and hemorrhagic or ischemic stroke. Current guidelines for traumatic brain injury, spontaneous intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and middle cerebral artery infarction are reviewed and lessons learned from the randomized controlled trials mentioned are discussed. In acute intracranial neurosurgical interventions, "delayed consent" procedures could play an important role for this field of research. Whether there is an optimal time window for acute intracranial neurosurgical interventions seems difficult to be answered with randomized controlled trials referred to in the current guidelines. Observational designs, such as comparative effectiveness research, and special statistical techniques, may provide a better understanding in the optimal "time-to-surgery."

Published
2022

44. Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial

Author

Post, René, primary, Germans, Menno R, additional, Tjerkstra, Maud A, additional, Vergouwen, Mervyn D I, additional, Jellema, Korné, additional, Koot, Radboud W, additional, Kruyt, Nyika D, additional, Willems, Peter W A, additional, Wolfs, Jasper F C, additional, de Beer, Frits C, additional, Kieft, Hans, additional, Nanda, Dharmin, additional, van der Pol, Bram, additional, Roks, Gerwin, additional, de Beer, Frank, additional, Halkes, Patricia H A, additional, Reichman, Loes J A, additional, Brouwers, Paul J A M, additional, van den Berg-Vos, Renske M, additional, Kwa, Vincent I H, additional, van der Ree, Taco C, additional, Bronner, Irene, additional, van de Vlekkert, Janneke, additional, Bienfait, Henri P, additional, Boogaarts, Hieronymus D, additional, Klijn, Catharina J M, additional, van den Berg, René, additional, Coert, Bert A, additional, Horn, Janneke, additional, Majoie, Charles B L M, additional, Rinkel, Gabriël J E, additional, Roos, Yvo B W E M, additional, Vandertop, W Peter, additional, Verbaan, Dagmar, additional, Post, René, additional, Germans, Menno R., additional, Tjerkstra, Maud A., additional, Vergouwen, Mervyn D.I., additional, Koot, Radboud W., additional, Kruyt, Nyika D., additional, Willems, Peter W.A., additional, Wolfs, Jasper F.C., additional, de Beer, Frits C., additional, Halkes, Patricia H.A., additional, Reichman, Loes J.A., additional, Brouwers, Paul J.A.M., additional, van den Berg-Vos, Renske M., additional, Kwa, Vincent I.H., additional, van der Ree, Taco C., additional, Bienfait, Henri P., additional, Boogaarts, Hieronymus D., additional, Klijn, Catharina J.M., additional, van Bilzen, Martine, additional, Dieks, H.J.G., additional, de Gans, Koen, additional, ten Holter, J.B.M., additional, de Kruijk, Jelle R., additional, Leijzer, Charlie T.J.M., additional, Molenaar, Delmar, additional, van Oostenbrugge, Robbert J., additional, van Pamelen, Jeske, additional, Spaander, Fianne H.M., additional, Vermeer, Sarah E., additional, Voorend, J. Manuela, additional, Coert, Bert A., additional, Majoie, Charles B.L.M., additional, Rinkel, Gabriël J.E., additional, Roos, Yvo B.W.E.M., additional, and Vandertop, W. Peter, additional

Published
2021
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45. Deferred Consent in an Acute Stroke Trial from a Patient, Proxy, and Physician Perspective: A Cross-Sectional Survey

Author

Koopman, Inez, primary, Verbaan, Dagmar, additional, Vandertop, W. Peter, additional, van der Graaf, Rieke, additional, Kompanje, Erwin J. O., additional, Post, René, additional, Coert, Bert A., additional, Ploem, Martine C., additional, Sluis, Wouter M., additional, Scheijmans, Féline E. V., additional, Rinkel, Gabriel J. E., additional, and Vergouwen, Mervyn D. I., additional

Published
2021
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46. Prehemorrhage antiplatelet use in aneurysmal subarachnoid hemorrhage and impact on clinical outcome

Author

Sebök, Martina, primary, Hostettler, Isabel C, additional, Keller, Emanuela, additional, Rautalin, Ilari M, additional, Coert, Bert A, additional, Vandertop, William P, additional, Post, René, additional, Sardeha, Ali, additional, Tjerkstra, Maud A, additional, Regli, Luca, additional, Verbaan, Dagmar, additional, and Germans, Menno R, additional

Published
2021
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47. Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial

Author

Post, René, Germans, Menno R, Tjerkstra, Maud A, Vergouwen, Mervyn D I, Jellema, Korné, Koot, Radboud W, Kruyt, Nyika D, Willems, Peter W A, Wolfs, Jasper F C, de Beer, Frits C, Kieft, Hans, Nanda, Dharmin, van der Pol, Bram, Roks, Gerwin, de Beer, Frank, Halkes, Patricia H A, Reichman, Loes J A, Brouwers, Paul J A M, van den Berg-Vos, Renske M, Kwa, Vincent I H, van der Ree, Taco C, Bronner, Irene, van de Vlekkert, Janneke, Bienfait, Henri P, Boogaarts, Hieronymus D, Klijn, Catharina J M, van den Berg, René, Coert, Bert A, Horn, Janneke, Majoie, Charles B L M, et al, University of Zurich, and Post, René

Subjects
10180 Clinic for Neurosurgery, 610 Medicine & health, 2700 General Medicine
Published
2021

48. Additional file 1 of Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial

Author

van Erp, Inge A. M., van Essen, Thomas A., Fluiter, Kees, van Zwet, Erik, van Vliet, Peter, Baas, Frank, Haitsma, Iain, Verbaan, Dagmar, Coert, Bert, de Ruiter, Godard C. W., Moojen, Wouter A., van der Jagt, Mathieu, and Peul, Wilco C.

Abstract

Additional file 1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2013 checklist.

Published
2021
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49. Additional file 2 of Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial

Author

van Erp, Inge A. M., van Essen, Thomas A., Fluiter, Kees, van Zwet, Erik, van Vliet, Peter, Baas, Frank, Haitsma, Iain, Verbaan, Dagmar, Coert, Bert, de Ruiter, Godard C. W., Moojen, Wouter A., van der Jagt, Mathieu, and Peul, Wilco C.

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Data_FILES, ComputingMilieux_LEGALASPECTSOFCOMPUTING
Abstract

Additional file 2. Ethical approval document.

Published
2021
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50. Additional file 4 of Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial

Author

van Erp, Inge A. M., van Essen, Thomas A., Fluiter, Kees, van Zwet, Erik, van Vliet, Peter, Baas, Frank, Haitsma, Iain, Verbaan, Dagmar, Coert, Bert, de Ruiter, Godard C. W., Moojen, Wouter A., van der Jagt, Mathieu, and Peul, Wilco C.

Abstract

Additional file 4. Informed consent form.

Published
2021
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