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Your search keyword '"Cocchiararo M"' showing total 9 results
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9 results on '"Cocchiararo M"'

1. Ultrastructural changes in mouse liver cells: a morphometric study on the influence of morphine, heroin, and cardiostenol

Author

A Lambiase, Crowell J, G. D'alfonso, M. Piazza, N. Abrescia, W. Schreil, Cocchiararo M, Borgia G, Borgia, Guglielmo, J., Crowell, M., Cocchiararo, N., Abrescia, A., Lambiase, G., D'Alfonso, W., Schreil, and M., Piazza

Subjects
Drug, Atropine, Pathology, medicine.medical_specialty, media_common.quotation_subject, Sparteine, Physiology, Mitochondria, Liver, Cardiostenol, Endoplasmic Reticulum, Heroin, Mice, mental disorders, Medicine, Animals, Molecular Biology, media_common, Morphine, business.industry, Endoplasmic reticulum, medicine.disease, Drug Combinations, Microscopy, Electron, Liver, Ultrastructure, Anatomy, business, Viral hepatitis, Liver ultrastructure, medicine.drug
Abstract

In drug addicts viral hepatitis is more frequent, its course is longer, and the percentage of chronic complications is higher than in nonaddicts. In addition many apparently healthy addicts show evidence of hepatic disfunction when screened. The role of the drug and its contaminants in this medical situation is not clear. In this paper we describe the effect of morphine, heroin, and Cardiostenol on normal mouse liver ultrastructure using morphometric methods. A statistically significant increase in volume density and surface density of smooth endoplasmic reticulum has been observed.

Published
1982

3. [Ultrastructural changes in hepatocytes of mice treated with heroin]

Author

BORGIA, GUGLIELMO, M. Cocchiararo, J. Crowell, A. Lambiase, S. Nappa, W. Schreil, M. Piazza, Borgia, Guglielmo, Cocchiararo, M., Crowell, J., Lambiase, A., Nappa, S., Schreil, W., and Piazza, M.

Abstract

In a study of the ultrastructure of a hepatocytes in mice treated with heroin a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum and mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with heroin increased significantly when compared to mice of the control group. An increase in volume density of SER is generally believed to be correlated to an increase in drug metabolizing enzymes localized in or on smooth endoplasmic reticulum membranes. We have demonstrated a statistically significant increase in SER in mice treated with heroin which is not accompanied by an increase in drug metabolizing enzymes (7). We feel that further investigation of these anomalous cases is necessary in order to clarify the role of the SER membranes and their function in the metabolism of drugs.

Published
1982

4. [Ultrastructural changes in hepatocytes of mice treated with morphine]

Author

BORGIA, GUGLIELMO, J. Crowell, M. Cocchiararo, A. Lambiase, S. Nappa, W. Schreil, M. Piazza, Borgia, Guglielmo, Crowell, J., Cocchiararo, M., Lambiase, A., Nappa, S., Schreil, W., and Piazza, M.

Abstract

In a study of the ultrastructure of hepatocytes in mice treated with morphine a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with morphine increased significantly when compared to mice of control group (P less than 0.05 for surface density of smooth endoplasmic reticulum and P less than 0.01 for volume density of smooth endoplasmic reticulum). These ultrastructural changes after administration of morphine and related opiates are not accompanied by an increase of drug metabolizing enzymes and the huge tolerance observed in mice can be a phenomenon of adaptation at the receptor site (4).

Published
1982

5. [Muco-ciliary clearance and the ultrastructure of cilia. I. Ultrastructural changes of the cilia in bronchopneumopathies].

Author

Borgia G, Cocchiararo M, Crowell J, Lambiase L, Cantatore D, and Olivieri D

Subjects
Adolescent, Adult, Aged, Bronchi abnormalities, Bronchi pathology, Bronchitis pathology, Child, Epithelium pathology, Female, Humans, Kartagener Syndrome pathology, Lung abnormalities, Male, Middle Aged, Bronchial Diseases pathology, Cilia ultrastructure, Lung Diseases pathology
Published
1980

6. [Muco-ciliary clearance and the ultrastructure of cilia. II. Evaluation of muco-ciliary transport in the trachea using bronchofibroscopy (modified Sackner method)].

Author

Olivieri D, Cantatore D, Borgia G, Cocchiararo M, and Nappa S

Subjects
Adult, Bronchi abnormalities, Bronchi physiopathology, Bronchitis physiopathology, Bronchoscopy, Fiber Optic Technology, Humans, Kartagener Syndrome physiopathology, Lung abnormalities, Middle Aged, Cilia physiology, Trachea physiopathology
Published
1980

7. [Ultrastructural changes in hepatocytes of mice treated with morphine].

Author

Borgia G, Crowell J, Cocchiararo M, Lambiase A, Nappa S, Schreil W, and Piazza M

Subjects
Animals, Endoplasmic Reticulum ultrastructure, Liver drug effects, Mice, Liver ultrastructure, Morphine pharmacology
Abstract

In a study of the ultrastructure of hepatocytes in mice treated with morphine a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with morphine increased significantly when compared to mice of control group (P less than 0.05 for surface density of smooth endoplasmic reticulum and P less than 0.01 for volume density of smooth endoplasmic reticulum). These ultrastructural changes after administration of morphine and related opiates are not accompanied by an increase of drug metabolizing enzymes and the huge tolerance observed in mice can be a phenomenon of adaptation at the receptor site (4).

Published
1982

8. [Ultrastructural changes in hepatocytes of mice treated with heroin].

Author

Borgia G, Cocchiararo M, Crowell J, Lambiase A, Nappa S, Schreil W, and Piazza M

Subjects
Animals, Endoplasmic Reticulum ultrastructure, Liver drug effects, Mice, Mitochondria, Liver ultrastructure, Heroin pharmacology, Liver ultrastructure
Abstract

In a study of the ultrastructure of a hepatocytes in mice treated with heroin a statistically significant increase in the volume density and surface density of smooth endoplasmic reticulum (SER) was observed. Morphometric measurements using the method described by Weibel (2,3) were employed to calculate volume density of smooth and rough endoplasmic reticulum and mitochondria, and surface density of rough and smooth endoplasmic reticulum membranes and of the mitochondrial envelope and cristae. Statistical analysis using the t test of Student was carried out for all parameters. Both surface density and volume density of SER in mice treated with heroin increased significantly when compared to mice of the control group. An increase in volume density of SER is generally believed to be correlated to an increase in drug metabolizing enzymes localized in or on smooth endoplasmic reticulum membranes. We have demonstrated a statistically significant increase in SER in mice treated with heroin which is not accompanied by an increase in drug metabolizing enzymes (7). We feel that further investigation of these anomalous cases is necessary in order to clarify the role of the SER membranes and their function in the metabolism of drugs.

Published
1982

9. "Lipid storage myopathy" with muscle carnitine deficiency only.

Author

Buscaino GA, Marolda M, Borgia A, Cocchiararo M, and Scarafile P

Subjects
Adult, Blood Pressure, Heart Rate, Humans, Male, Carnitine deficiency, Lipid Metabolism, Inborn Errors physiopathology, Muscles physiopathology, Muscular Diseases physiopathology
Published
1982

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