1. First report of cerebellar abiotrophy in an Arabian foal from Argentina
- Author
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Silvina Díaz, Gonzalo Julián Madariaga, Silvia Andrea Olguin, Claudia Malena Corbi Botto, Sebastian Andres Sadaba, María Eugenia Zappa, M.H. Carino, Pilar Peral García, and Adriana Raquel Massone
- Subjects
medicine.medical_specialty ,Pathology ,Cerebellar abiotrophy ,040301 veterinary sciences ,Case Report ,Apoptosis ,Biology ,Arabian horses ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,CEREBELLAR ABIOTROPHY ,Internal medicine ,biology.animal ,Otras Ciencias Veterinarias ,medicine ,Infectious encephalitis ,Blood test ,Arabian horse ,Hematology ,General Veterinary ,medicine.diagnostic_test ,Ciencias Veterinarias ,04 agricultural and veterinary sciences ,Anatomy ,DNA ,people.cause_of_death ,APOPTOSIS ,ARABIAN HORSE ,Foal ,QL1-991 ,CIENCIAS AGRÍCOLAS ,Purkinje cells ,Apoptosis, Arabian horses, Cerebellar abiotrophy, DNA, Purkinje cells ,purl.org/becyt/ford/4.3 [https] ,people ,Zoology ,purl.org/becyt/ford/4 [https] ,030217 neurology & neurosurgery ,Pyknosis - Abstract
Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina., Instituto de Genética Veterinaria, Facultad de Ciencias Veterinarias
- Published
- 2016