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First report of cerebellar abiotrophy in an Arabian foal from Argentina
- Source :
- Open Veterinary Journal, Vol 6, Iss 3, Pp 259-262 (2016), Open Veterinary Journal, SEDICI (UNLP), Universidad Nacional de La Plata, instacron:UNLP, Open Veterinary Journal; Vol 6, No 3 (2016); 259-262, CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2016
- Publisher :
- Tripoli University, 2016.
-
Abstract
- Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.<br />Instituto de Genética Veterinaria<br />Facultad de Ciencias Veterinarias
- Subjects :
- medicine.medical_specialty
Pathology
Cerebellar abiotrophy
040301 veterinary sciences
Case Report
Apoptosis
Biology
Arabian horses
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
CEREBELLAR ABIOTROPHY
Internal medicine
biology.animal
Otras Ciencias Veterinarias
medicine
Infectious encephalitis
Blood test
Arabian horse
Hematology
General Veterinary
medicine.diagnostic_test
Ciencias Veterinarias
04 agricultural and veterinary sciences
Anatomy
DNA
people.cause_of_death
APOPTOSIS
ARABIAN HORSE
Foal
QL1-991
CIENCIAS AGRÍCOLAS
Purkinje cells
Apoptosis, Arabian horses, Cerebellar abiotrophy, DNA, Purkinje cells
purl.org/becyt/ford/4.3 [https]
people
Zoology
purl.org/becyt/ford/4 [https]
030217 neurology & neurosurgery
Pyknosis
Subjects
Details
- Language :
- English
- ISSN :
- 22186050 and 22264485
- Volume :
- 6
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Open Veterinary Journal
- Accession number :
- edsair.doi.dedup.....1cc3a1af223ddeb8feea18ceb86f24d1