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156 results on '"Cioffi C"'

1. Interventions to Support Engagement in Addiction Care Postpartum: Principles and Pitfalls

Author

Mazel S, Alexander K, Cioffi C, and Terplan M

Subjects
pregnancy, substance use disorder, harm reduction, medication for oud, Public aspects of medicine, RA1-1270
Abstract

Shayna Mazel,1,* Karen Alexander,2,* Camille Cioffi,3,* Mishka Terplan2,* 1Institute for Behavioral Health, Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA; 2Friends Research Institute, Baltimore, MD, USA; 3Center on Parenting and Opioids, Prevention Science Institute, University of Oregon, Eugene, OR, USA*These authors contributed equally to this workCorrespondence: Mishka Terplan, Friends Research Institute, 1040 Park Ave, Suite 103, Baltimore, MD, 21201, USA, Tel +1 410 837 3977, Fax +1 410 752 4218, Email mterplan@friendsresearch.orgAbstract: There is a fundamental disconnect between the optimal management of addiction in general and care delivery in pregnancy and postpartum. Addiction is a chronic condition requiring some degree of management across the life course. Yet, in the US, reproductive care is episodic and centers more on pregnancy than at other stages of the reproductive life course. Pregnancy is prioritized in access to insurance as almost all pregnant people are Medicaid eligible but access ends at varying points postpartum. This results in a structural mismatch: the episodic management of the chronic condition of addiction only within gestational periods. Though people with substance use disorder (SUD) may access care in pregnancy, treatment attrition is common postpartum. Postpartum is a time of increased vulnerabilities where insurance churn and newborn caretaking responsibilities collide in a context of care withdrawal from the health system and health providers. In part in consequence, return to use, SUD recurrence, overdose, and overdose death are more common postpartum than in pregnancy, and drug deaths have become a leading cause of maternal deaths in the US. This review addresses interventions to support engagement in addiction care postpartum. We begin with a scoping review of model programs and evidence-informed interventions that have been shown to increase continuation of care postpartum. We then explore the realities of contemporary care through a review of clinical and ethical principles, with particular attention to harm reduction. We conclude with suggestions of strategies (clinical, research, and policy) to improve care postpartum and highlight potential pitfalls in the uptake of evidence-based and person-centered services.Keywords: pregnancy, substance use disorder, harm reduction, medication for OUD

Published
2023

2. POOL File Catalog, Collection and Metadata Components

Author

Cioffi, C., Eckmann, S., Girone, M., Hrivnac, J., Malon, D., Schmuecker, H., Vaniachine, A., Wojcieszuk, J., and Xie, Z.

Subjects
Computer Science - Databases, H.2.4
Abstract

The POOL project is the common persistency framework for the LHC experiments to store petabytes of experiment data and metadata in a distributed and grid enabled way. POOL is a hybrid event store consisting of a data streaming layer and a relational layer. This paper describes the design of file catalog, collection and metadata components which are not part of the data streaming layer of POOL and outlines how POOL aims to provide transparent and efficient data access for a wide range of environments and use cases - ranging from a large production site down to a single disconnected laptops. The file catalog is the central POOL component translating logical data references to physical data files in a grid environment. POOL collections with their associated metadata provide an abstract way of accessing experiment data via their logical grouping into sets of related data objects., Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 4 pages, 1 eps figure, PSN MOKT009

Published
2003

4. PC.25 - Etude de stratégie thérapeutique, randomisée, en dble aveugle, évaluant la poursuite du traitement par certolizumab pegol à posologie inchangée ou après espacement des doses vs arrêt du traitement pour maintenir une LDA chez des pts ayant une PR débutante

Author

Mariette, X., Emery, P., Bingham, C., Burmester, G., Bykerk, V., Furst, D.E., Van Der Heijde, D., Van Vollenhoven, R., Vanlunen, B., Ecoffet, C., Cioffi, C., and Weinblatt, M.

Published
2016
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5. Pack rust corrosion evaluation on historical riveted steel bridges [Studio dei fenomeni di corrosione in fessura di ponti chiodati di valenza storica]

Author

Lorenzi, Sergio, Cabrini, Marina, Coppola, Luigi, Ferrari, Claudia, Ferrari, Rosalba, Rizzi, Egidio, Pastore, Tommaso, Spirolazzi, G., Pisanelli, G., Cioffi, C., and Lizzori, E.

Subjects
Crevice corrosion, Settore ING-IND/22 - Scienza e Tecnologia dei Materiali, Corrosion of infrastructures, Atmosferic corrosion, Corrosion of cultural heritage
Published
2021

8. Strumenti di gestione e pianificazione dei beni paesaggistici

Author

Cioffi, C and Cioffi, C

Subjects
paesaggio
Abstract

strumenti per la gestione della tutela del paesaggio adeguati ai principi della convenzione europea ratificata nel 2004 nonché alle finalità di tutela del codice "urbani"

Published
2019

10. Fenomeni di corrosione delle infrastrutture metalliche di rilevanza storica

Author

Pastore, Tommaso, Cabrini, Marina, Lorenzi, Sergio, Rizzi, Egidio, Ferrari, Rosalba, Coppola, Luigi, Spirolazzi, G., Pisanelli, G., Cioffi, C., and Lizzori, E.

Subjects
Corrosion, Historic Infrastructures, Protection, Metals, Corrosione nel calcestruzzo, Corrosione nel calcestruzzo, Carbonatazione del calcestruzzo, Inibitori di corrosione, Nitrato, Nitrito, Settore ING-IND/22 - Scienza e Tecnologia dei Materiali, Nitrato, Carbonatazione del calcestruzzo, Corrosion, Historic Infrastructures, Metals, Protection, Inibitori di corrosione, Nitrito
Published
2020

13. POOL development status and production experience

Author

Chytracek, R., Dullmann, D., Frank, M., Girone, M., Govi, G., Moscicki, J.T., Papadopoulos, I., Schmuecker, H., Karr, K., Malon, D., Vaniachine, A., Tanenbaum, W., Xie, Z., Barrass, T., and Cioffi, C.

Subjects
Particle accelerators -- Research, Nuclear physics -- Research, Business, Electronics, Electronics and electrical industries
Abstract

The pool of persistent objects for LHC (POOL) project, part of the large Hadron collider (LHC) computing grid (LCG), is now entering its third year of active development. POOL provides the baseline persistency framework for three LHC experiments. It is based on a strict component model, insulating experiment software from a variety of storage technologies. This paper gives a brief overview of the POOL architecture, its main design principles and the experience gained with integration into LHC experiment frameworks. It also presents recent developments in the POOL works areas of relational database abstraction and object storage into relational database management systems (RDBMS) systems. Index Terms--Data persistency, object streaming, plug-in architecture, relational database.

Published
2005

16. Double neutralisation des interleukines (IL) 17A et IL 17F par bimékizumab dans le psoriasis en plaques modéré à sévère : résultats à 60 semaines d’une étude d’extension randomisée, en double aveugle de phase 2b

Author

Blauvelt, A., primary, Papp, K.A., additional, Merola, J., additional, Gottlieb, A.B., additional, Cross, N., additional, Madden, C., additional, Wang, M., additional, Cioffi, C., additional, Pasquereau, Y., additional, and Griffiths, C.E.M., additional

Published
2019
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17. Eine randomisierte, doppelblinde Behandlungsstrategie-Studie, die das Fortsetzen von Certolizumab Pegol oder ein reduziertes Dosisintervall versus Absetzen zur Beibehaltung einer geringen Krankheitsaktivität bei Patienten mit früher RA überprüft

Author

Burmester, GR, Emery, P, Bingham 3rd, CO, Bykerk, V, Furst, D, Mariette, X, van der Heijde, D, van Vollenhoven, R, VanLunen, B, Ecoffet, C, Cioffi, C, and Weinblatt, ME

Subjects
c-early, ddc: 610, DMARD-naive, Certolizumab Pegol, frühe Rheumatoide Arthritis, 610 Medical sciences, Medicine
Abstract

Einleitung: MTX in Kombination mit TNF-Blockern ist eine effektive Behandlung für frühe RA. Es wird zunehmend wichtiger, zu verstehen, ob die Dosis von TNF-Blockern bei langzeittherapierten Patienten (Pat.), reduziert oder abgesetzt werden kann. Ziel der Studie war es zu prüfen, ob[zum vollständigen Text gelangen Sie über die oben angegebene URL], 44. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh); 30. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh); 26. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2016
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18. Etude de stratégie thérapeutique, randomisée, en dble aveugle, évaluant la poursuite du traitement par certolizumab pegol à posologie inchangée ou après espacement des doses vs arrêt du traitement pour maintenir une LDA chez des pts ayant une PR débutante

Author

Mariette, X., primary, Emery, P., additional, Bingham, C., additional, Burmester, G., additional, Bykerk, V., additional, Furst, D.E., additional, Van Der Heijde, D., additional, Van Vollenhoven, R., additional, Vanlunen, B., additional, Ecoffet, C., additional, Cioffi, C., additional, and Weinblatt, M., additional

Published
2016
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19. Comparaison du certolizumab pegol versus adalimumab : résultats d’efficacité et de tolérance à 2 ans d’une étude comparative directe de supériorité, en aveugle pour les investigateurs

Author

Chapurlat, R., primary, Fleischmann, R., additional, Burmester, G., additional, Combe, B., additional, Curtis, J., additional, Hall, S., additional, Haraoui, B., additional, Van Vollenhoven, R., additional, Cioffi, C., additional, Ecoffet, C., additional, Ionescu, L., additional, Gervitz, L., additional, Peterson, L., additional, and Smolen, J.S., additional

Published
2016
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20. OP0227 A Randomized Double-Blind Treatment Strategy Study Evaluating Continuation or Reduced-Frequency Dosing of Certolizumab Pegol versus Withdrawal To Maintain Low Disease Activity in Early RA Patients (C-Early Period 2)

Author

Emery, P., primary, Bingham, C., additional, Burmester, G.-R., additional, Bykerk, V.P., additional, Furst, D., additional, Mariette, X., additional, van der Heijde, D., additional, van Vollenhoven, R., additional, VanLunen, B., additional, Ecoffet, C., additional, Cioffi, C., additional, and Weinblatt, M., additional

Published
2016
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22. Revoca della donazione

Author

Damiani, E., Cioffi, C., Perfetti, U., Emiliozzi, E. A., Barchiesi, Luca, Agostinelli, B., Verdi, M., Bertotto, A., Restuccia, R., Bottoni, F., Cricenti, G., Montecchiari, Tiziana, Costanza, M., Ieva, M., Rossi, F., Puligheddu, C., Cutino, F., Centore, P., Manes, P., Ferrari, C., and Ugolini, S.

Published
2010

23. Forma della donazione

Author

Damiani, E., Cioffi, C., Perfetti, U., Emiliozzi, E. A., Barchiesi, Luca, Agostinelli, B., Verdi, M., Bertotto, A., Restuccia, R., Bottoni, F., Cricenti, G., Montecchiari, Tiziana, Costanza, M., Ieva, M., Rossi, F., Puligheddu, C., Cutino, F., Centore, P., Manes, P., Ferrari, C., and Ugolini, S.

Published
2010

24. LHCb RICH1 Engineering Design Review Report

Author

Brook, N, Head, R, Metlica, F, Muir, A, Phillips, A, Buckley, A, Gibson, V, Harrison, K, Jones, C R, Katvars, S G, Lazzeroni, C, Storey, J, Ward, CP, Wotton, S, Alemi, M, Arnabaldi, C, Bellunato, T F, Calvi, M, Matteuzzi, C, Musy, M, Negri, P, Perego, D L, Pessina, G, Chamonal, R, Eisenhardt, S, Lawrence, J, McCarron, J, Muheim, F, Playfer, S, Walker, A, Cuneo, S, Fontanelli, F, Gracco, Valerio, Mini, G, Musico, P, Petrolini, A, Sannino, M, Bates, A, MacGregor, A, O'Shea, V, Parkes, C, Paterson, S, Petrie, D, Pickford, A, Rahman, M, Soler, F, Allebone, L, Barber, J H, Cameron, W, Clark, D, Dornan, Peter John, Duane, A, Egede, U, Hallam, R, Howard, A, Plackett, R, Price, D, Savidge, T, Vidal-Sitjes, G, Websdale, D M, Adinolfi, M, Bibby, J H, Cioffi, C, Gligorov, Vladimir V, Harnew, N, Harris, F, McArthur, I A, Newby, C, Ottewell, B, Rademacker, J, Senanayake, R, Somerville, L P, Soroko, A, Smale, N J, Topp-Jørgensen, S, Wilkinson, G, Yang, S, Benayoun, M, Khmelnikov, V A, Obraztsov, V F, Densham, C J, Easo, S, Franek, B, Kuznetsov, G, Loveridge, P W, Morrow, D, Morris, JV, Papanestis, A, Patrick, G N, Woodward, M L, Aglieri-Rinella, G, Albrecht, A, Braem, André, Campbell, M, D'Ambrosio, C, Forty, R W, Frei, C, Gys, Thierry, Jamet, O, Kanaya, N, Losasso, M, Moritz, M, Patel, M, Piedigrossi, D, Snoeys, W, Ullaland, O, Van Lysebetten, A, and Wyllie, K

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment, Detectors and Experimental Techniques
Abstract

This document describes the concepts of the engineering design to be adopted for the upstream Ring Imaging Cherenkov detector (RICH1) of the reoptimized LHCb detector. Our aim is to ensure that coherent solutions for the engineering design and integration for all components of RICH1 are available, before proceeding with the detailed design of these components.

Published
2005

25. Experience with POOL from the LCG Data Challenges of the three LHC experiments

Author

Dullmann, D., Girone, M., Branco, M., Chytracek, R., Frank, M., Goossens, L., Govi, G., Innocente, V., Papadopoulos, I., Moscicki, J., Schmucker, H., Karr, K., Malon, D., Vaniachine, A., Claudio Grandi, Tanenbaum, W., Tuura, Lassi A., Xie, Z., Barrass, T., and Cioffi, C.

Subjects
Computing and Computers
Published
2005

26. File-Metadata Management System For The LHCb Experiment

Author

Cioffi, C, Closier, J, Frank, M, Loverre, P F, and Ponce, S

Subjects
Detectors and Experimental Techniques, Computing and Computers
Abstract

The LHCb experiment [1] needs to store all of the information about datasets and their processing history from particle collisions at the Large Hadron Collider at CERN [2], as well as for simulated data. To achieve this functionality, a design based on data warehousing techniques has been chosen, where several user-services can be implemented and optimized individually without losing functionality or performance. This approach results in an experiment-independent and flexible system. It allows fast access to the catalogue of available data, to detailed history information and to the catalogue of data replicas. Queries can be made based on these three sets of information. A flexible underlying database schema allows the implementation and evolution of these services without the need to change the basic database schema. The consequent implementation of interfaces based on XML-RPC allows access and modification of the stored information using a well-defined encapsulating API. In this document, we discuss the definition of metadata describing datasets and how these data are used by LHCb physicists to retrieve and access data from simulated particle collisions

Published
2005

27. Housing metadata for the common physicist using a relational database

Author

Merritt, K, Saint-Denis, R, Trumbo, J, Kennedy, R, Kreymer, A, Lueking, L, Ratnikov, F, White, S, Sill, A, Leslie, M, Stonjek, S, Terekhov, I, Bartsch, V, Belforte, S, Veseli, S, Baranovski, A, Loebel-Carpenter, L, Kerzel, U, Garzoglio, G, Herber, R, Illingworth, R, Cioffi, C, Hanlon, S, Nicholson, C, Doyle, T, McCance, G, Albrand, S, Stojek, S, Merritt, W, Lyon, A, Burgon-Lyon, M, Millar, P, Barrass, T, Kunszt, Peter Z, Nienartowicz, K, Rocha, R, Vokac, P, Zimmler, M, Fulachier, J, bibliotheque, LPSC, A. Aimar, J. Harvey, N. Knoors, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), A. Aimar, J. Harvey, and N. Knoors

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Computing and Computers
Abstract

SAM was developed as a data handling system for Run II at Fermilab. SAM is a collection of services, each described by metadata. The metadata are modeled on a relational database, and implemented in ORACLE. SAM, originally deployed in production for the D0 Run II experiment, has now been also deployed at CDF and is being commissioned at MINOS. This illustrates that the metadata decomposition of its services has a broader applicability than just one experiment. A joint working group on metadata with representatives from ATLAS, BaBar, CDF, CMS, D0, and LHCB in cooperation with EGEE has examined this metadata decomposition in the light of general HEP user requirements. Greater understanding of the required services of a performant data handling system has emerged from Run II experience. This experience is being merged with the understanding being developed in the course of LHC experience with data challenges and user case discussions. We describe the SAM schema and the commonalities of function and service support between this schema and proposals for the LHC experiments. We describe the support structure required for SAM schema updates, the use of development, integration, and production instances. We are also looking at the LHC proposals for the evolution of schema using keyword-value pairs that are then transformed into a normalized, performant database schema.

Published
2005

28. LHCb Computing Technical Design Report

Author

Antunes-Nobrega, R, França-Barbosa, A, Bediaga, I, Cernicchiaro, G, Correade-Oliveira, E, Magnin, J, Manhaes de Andrade-Filho, L, Marques de Miranda, J, Pessoa Lima Junior, H, Reis, A, Akiba, K, Amato, S, Da Silva, T, De Mello-Neto, J R T, De Paula, B, De Paula, L, Gandelman, M, Lopes, J H, Maréchal, B, Marinho, F, Massafferri, A, Polycarpo, E, Boget, D, Bret, A, Delebecque, P, De Bonis, I, Décamp, D, Drancourt, C, Dumont-Dayot, N, Girard, C, Lieunard, B, Minard, M N, Moreau, S, Pietrzyk, B, Rambure, T, Terrier, H, Ajaltouni, Ziad J, Böhner, G, Borras, D, Cârloganu, C, Conte, E, Cornat, R, Delage, E, Deschamps, O, Henrard, P, Lecoq, J, Magne, M, Monteil, S, Perret, P, Reinmuth, G, Rimbault, C, Robert, A, Aslanides, E, Babel, J, Benchouk, C, Cachemiche, J P, Cogan, J, Dinkespiler, B, Duval, P Y, Le Gac, R, Lunesu, D, Garonne, V, Leroy, O, Liotard, P L, Marin, F, Tsaregorodtsev, A Yu, Barrand, G, Beigbeder-Beau, C, Beneyton, R, Breton, D, Callot, O, Charlet, D, D'Almagne, B, Delcourt, B, Duarte, O, Fulda-Quenzer, F, Jean-Marie, B, Lefrançois, J, Machefert, F, Robbe, P, Schune, M H, Tocut, V, Videau, I, Benayoun, M, Del Buono, L, David, P, Gilles, G, Nedos, M, Spaan, B, Agari, M, Bauer, C, Blouw, J, Fuchs, H P, Hofmann, W, Knöpfle, K T, Löchner, S, Müller, A S, Schmelling, M, Schwingenheuer, B, Smale, N J, Bachmann, S, Eisele, F, Haas, T, Henneberger, S, Igo-Kemenes, P, Kisel, I, Lindenstruth, V, Stange, U, Trunk, U, Wiedner, D, Uwer, U, Alfonsi, M, Bencivenni, G, Bloise, C, Bossi, F, Campana, P, Capon, G, Ciambrone, P, De Simone, P, Felici, G, Forti, C, Lanfranchi, G, Murtas, F, Patera, V, Poli-Lener, M, Saputi, A, Sarti, A, Sciubba, A, Avoni, G, Balbi, G, Bargiotti, M, Bertin, A, Bortolotti, D, Bruschi, M, Carbone, A, De Castro, S, Faccioli, P, Fabbri, L, Galli, D, Giacobbe, B, Gregori, D, Grimaldi, F, Lax, I, Marconi, U, Massa, I, Peco, G, Piccinini, M, Semprini-Cesari, N, Spighi, R, Vagnoni, V, Vecchi, S, Villa, M, Vitale, A, Zoccoli, A, Bonivento, W, Cadeddu, S, Cardini, A, De Leo, V, Deplano, C, Lai, A, Raspino, D, Saitta, B, Baldini, W, Carassiti, V, Cotta-Ramusino, A, Dalpiaz, P, Germani, S, Gianoli, A, Martini, M, Petrucci, F, Savrié, M, Bizzeti, A, Graciani, G, Lenti, M, Lenzi, M, Passaleva, G, Pelfer, P G, Veltri, M, Cuneo, S, Fontanelli, F, Gracco, V, Mini, G, Musico, P, Petrolini, A, Sannino, M, Alemi, M, Arnaboldi, C, Bellunato, T F, Calvi, M, Garibaldi, F, Matteuzzi, C, Musy, M, Negri, P, Panzeri, E, Perego, D L, Pessina, G, Pukhaeva, N, Trentadue, L G, Auriemma, G, Bocci, V, Bosio, C, Dane, E, Fidanza, D, Frenkel, A, Iacoangeli, F, Martellotti, G, Penso, G, Petrarca, S, Pinci, D, Rinaldi, W, Santacesaria, R, Satriano, C, Satta, A, Carboni, G, De Capua, S, Messi, R, Santovetti, E, van Apeldoorn, G, Arink, R, Van Bakel, N, Bauer, T S, Van Beuzekom, M G, Van den Brand, J F J, Bos, E, Bulten, H J, Doets, M, Groenstege, H, Gromov, V, Hierck, R, Hommels, L, Jans, E, Ketel, T, Klous, S, Kraan, M J, Merk, M, Mul, F, Nardulli, J, Pellegrino, A, Raven, G, Rodrigues-Figueiredo, E M, Schuijlenburg, H, Sluijk, T, Tuning, N, Vankov, P, Verlaat, B, Van Tilburg, J, De Vries, H, Wiggers, L, Ybeles-Smit, G V, Zupan, M, Bisset, M, Cheng, J P, Cui, Y G, Dai, Y, Gao, Y, He, H J, Huang, C, Jiang, C, Kuang, Y P, Li, Q, Li, Y J, Liao, Y, Ni, J P, Shao Bei Bei, Su, J J, Tian, Y R, Wang, Q, Yan, Q S, Ciba, K, Hajduk, L, Kowal, A, Kucharczyk, M, Michalowski, J, Muryn, B, Oblakowska-Mucha, A, Polok, G, Witek, M, Adamus, M, Chlopik, A, Guzik, Z, Nawrot, A, Syryczynski, K, Szczekowski, M, Coca, C, Orlandea, M, Nicorescu, C, Stoica, S, Tarta, P D, Filippov, S, Gavrilov, J, Guschin, E, Kloubov, V, Kravchuk, L, Kutuzov, V, Laptev, S, Laptev, V, Marin, V, Rybkine, G, Sadovskii, A, Semeniouk, I N, Strigin, V, Alekseev, I, Arefev, A, Barsuk, S, Belyaev, I, Bobchenko, B M, Charkov, G, Dolgoshein, V, Golutvin, A, Gouchtchine, O, Kiritchenko, V, Kochetkov, V, Korolko, I, Kvaratskheliia, T, Machikhiliyan, I, Malyshev, S, Martemyanov, M, Mayatskaya, E, Melnikov, E A, Morozov, A, Pakhlov, P, Pakhlova, G, Petriaev, A, Pozolov, P, Prokudin, M, Roussinov, D, Rusinov, V, Semenov, S, Shuvalov, S, Soldatov, A, Svirida, D, Tarkovski, E, Voronchev, K, Zaitsev, V, Zhiryakova, O, Barnyakov, M, Beloborodov, K I, Berdiouguine, A, Bondar, A, Bozhenok, A, Buzulutskov, A F, Eidelman, S, Golubev, V, Krokovnyi, P P, Kuzmin, A, Oreshkin, S B, Poluektov, A, Serednyakov, S I, Shekhtman, L I, Shwartz, B, Silagadze, Z K, Vasilev, A, Ajnenko, I V, Belous, K S, Dzhelyadin, R I, Guz, Yu P, Kachnov, K, Katchaev, I, Khmelnikov, V A, Kisselev, V S, Kobelev, A, Konoplyannikov, A K, Likhoded, A K, Martchikine, N, Matveev, V D, Novikov, V, Obraztsov, V F, Ostankov, A P, Polyakov, V, Romanovski, V, Rykalin, V I, Shapkin, M M, Sokolov, A, Soldatov, M M, Talanov, V V, Yushchenko, O P, Alkhazov, G, Andreev, V, Botchine, B, Ganja, V, Goloubev, V, Guetz, S, Kashchuk, A, Lazarev, V, Maev, E, Maev, O, Petrov, G, Saguidova, N, Sementchouk, G, Smirnov, I, Souvorov, V, Spiridenkov, E, Vorobyov, A, Vorobyov, A A, Voropaev, N, Aguiló, E, Ballabriga-Sune, Rafael, Calvo, M, Comerma-Montells, A, Ferragut, S, Garrido, L, Gascón, D, Gonzales-Bano, C, Graciani-Díaz, R, Graugès-Pous, E, Luengo, S, Peralta, D, Roselló, M, Vilasís, X, Xirgu Aleixandre, J, Adeva, B, Esperante-Pereira, D, Lois-Gómez, C, Pazos, A, Pló, M, Saborido, J J, Sánchez-García, M, Vázquez-Regueiro, P, Bay, A, Borel, J, Carron, B, Fauland, P, Fernández, L, Frei, R, Haefeli, G, Hertig, J P, Van Hunen, J J, Jacoby, C, Jalocha, P, Jiménez-Otero, S, Legger, F, Locatelli, L, Perrin, A, Schietinger, T, Schneider, O, Tran, M T, Vervink, K, Villa, S, Voss, H, Zwahlen, N, Bernet, R, Bernhard, R P, Gassner, J, Köstner, S, Lehner, F, Needham, M, Steinkamp, O, Straumann, U, Vollhardt, A, Volyanskyy, D, Wenger, A, Ziegler, M, Dovbnya, A, Ranyuk, Y, Shapoval, I, Aushev, V, Filipchenko, Y, Kiva, V, Pavlenko, Yu, Pugatch, V, Brook, N H, Head, R D, Jia, Q, Metlica, F, Muir, A, Phillips, A, Szczypka, P, Wilson, F F, Buckley, A, Dickens, J, George, K, Gibson, V, Harrison, K, Jones, C R, Katvars, S G, Lazzeroni, C, Storey, J, Ward, C P, Wotton, S A, Densham, C J, Easo, S, Franek, B, Halsall, R N J, Kuznetsov, G, Loveridge, P W, Morrow, D, Morris, J V, Papanestis, A, Patrick, G N, Woodward, M L, Zhang, Z, Chamonal, R, Clark, P J, Earl, A, Eisenhardt, S, Gilarsi, N, Lawrence, J, McCarron, J, Muheim, F, Playfer, S, Smith, A, Thorn, S, Walker, A, Xie, Y, Flavell, A J, Bates, R, MacGregor, A, O'Shea, V, Parkes, C, Paterson, S, Petrie, D, Pickford, A, Saavedra, A, Soler, F J P, Szumlak, T, Viret, S, Biagi, S, Bowcock, T, Casse, G, Gamet, R, George, M, Hutchcroft, D E, Patel, G, Shears, T G, Stavitski, I, Tobin, M, Washbrook, A J, Allebone, L, Barber, G J, Blake, T, Cameron, W, Clark, D, Dornan, Peter John, Egede, U, Hallam, R, Howard, A, Jolly, S, Plackett, R, Price, D R, Savidge, T, Vidal-Sitjes, G, Websdale, D M, Adinolfi, M, Bibby, J H, Cioffi, C, Gligorov, V, Harnew, N, Harris, F, McArthur, I A, Muresan, R, Newby, C, Powell, A, Rademacker, J, Senanayake, R, Somerville, L P, Soroko, A, Stokes-Rees, I, Sullivan, P, Topp-Jørgensen, S, Wilkinson, G, Abadie, L, Aglieri-Rinella, G, Anelli, G, Bal, F, Barczyk, A, Batista-Lopes, J C, Bird, I, Bobillier, V, Braem, André, Brarda, L, Buytaert, J, Camilleri, L L, Campbell, M, Cattaneo, M, Charpentier, P, Christiansen, J, Clemencic, M, Closier, J, Collins, P, Corti, G, D'Ambrosio, C, Degaudenzi, H M, Dijkstra, H, Domenech-Saavedra, M, Dufey, J P, Eckstein, D, Eklund, L, Ferro-Luzzi, M, Flegel, W, Formenti, F, Forty, R W, Frank, M, Frei, C, Gaidioz, B, Gaspar, C, Gavillet, P, Gouldwell-Bates, A, Graulich, J S, Guirao-Elias, A, Gys, Thierry, Harvey, J, Hernando-Morata, J A, Van Herwijnen, Eric, Hilke, H J, Jacobsson, R, Joram, C, Jost, B, Kanaya, N, Koppenburg, P, Lacarrère, D, Lammana, M, Lastoviicka, T, Lindner, R, Losasso, M, Van Lysebetten, A, Maier, A, Mato-Vila, P, Moritz, M, Moscicki, J, Mücke, M, Nakada, T, Neufeld, N, Nogueira-Fernandes, R, Palacios, J, Patel, M, Pivk, M, Pokorski, Witold, Ponce, S, Ranjard, F, Roiser, S, Ruf, T, Ruffinoni, D, Ruiz-Pérez, H, Schmidt, B, Schneider, T, Schopper, A, Teubert, F, Ullaland, O, Vannerem, P, Witzeling, W, Wyllie, K, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), LHCb, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Pellet, Jeanine

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detectors and Experimental Techniques
Published
2005

29. POOL Development Status and Plans

Author

Düllmann, D, Papadopoulos, I M, Chytracek, R, Frank, M, Girone, M, Govi, G, Moscicki, J, Schmücker, H, Karr, K, Malon, D, Vaniachine, A, Barrass, T, Tannenbaum, W, Cioffi, C, and Xie, Z

Subjects
Computing and Computers
Published
2005

30. Developing LHCb Grid Software: Experiences and Advances

Author

Stokes-Rees, I, Soroko, A, Cioffi, C, Tsaregorodtsev, A, Garonne, V, Graciani, R, Sanchez, M, Frank, M, Closier, J, and Kuznetsov, G

Subjects
Detectors and Experimental Techniques, Computing and Computers
Abstract

The LHCb grid software has been used for two Physics Data Challenges, the most recent of which will have produced 90 TB of data and required over 400 processor-years of computing power. This paper discusses the group's experience with developing Grid Services, interfacing to the LCG, running LHCb experiment software on the grid, and the integration of a number of new technologies into the LHCb grid software. Our experience and utilisation of the following core technologies will be discussed: OGSI, XML-RPC, grid services, LCG middle-ware, and instant messaging.

Published
2004

31. File-Metadata Management System for the LHCb Experiment

Author

Cioffi, C

Subjects
Talk
Abstract

The LHCb experiment needs to store all the information about the datasets and their processing history of recorded data resulting from particle collisions at the LHC collider at CERN as well as of simulated data. To achieve this functionality a design based on data warehousing techniques was chosen, where several user-services can be implemented and optimized individually without losing functionality nor performance. This approach results in an experiment- independent and flexible system. It allows fast access to the catalogue of available data, to detailed history information and to the catalogue of data replicas. Queries can be made based on these three sets of information. A flexible underlying database schema allows the implementation and evolution of these services without the need to change the basic database schema. The consequent implementation of interfaces based on XML-RPC allows to access and to modify the stored information using a well defined encapsulating API.

Published
2004

32. LHCb reoptimized detector design and performance : Technical Design Report

Author

Antunes Nobrega, R., Franca Barbosa, A., Bediaga, I., Cernicchiaro, G., Correade Oliveira, E., Magnin, J., Marquesde Miranda, J., Massafferri, A., Polycarpo, E., Reis, A., Akiba, K., Amato, S., Da Silva, T., De Mello-Neto, J.R.T., De Paula, B., De Paula, L., Gandelman, M., H. Lopes, J., Maréchal, B., Marinho, F., Moraes, D., Pelloux, N., Nunes, C., Perreira Nunes, C., Ballansat, J., Boget, D., Delebecque, P., De Bonis, I., Décamp, D., Drancourt, C., Dumont-Dayot, N., Girard, Christian, Lieunard, B., Minard, M.N., Pietrzyk, B., Terrier, H., Ajaltouni, Ziad, Bohner, G., Cârloganu, C., Cornat, R., Deschamps, O., Henrard, Pierre, Lecoq, J., Lefèvre, R., Monteil, S., Perret, Pascal, Rimbault, Cécile, Robert, A., Aslanides, E., P. Cachemiche, J., Dinkespiler, B., Y. Duval, P., Le Gac, R., Garonne, V., Leroy, O., L. Liotard, P., Menouni, M., Tsaregorodtsev, A., Viaud, B., Barrand, G., Beigbeder-Beau, C., Beneyton, R., Breton, D., Callot, O., Charlet, D., D'Almagne, B., Delcourt, B., Duarte, O., Fulda-Quenzer, F., Jean-Marie, B., Lefrançois, J., Machefert, F., Robbe, P., Schune, V., Tocut, M.H., Truong, K., Schwierz, R., Spaan, B., Agari, M., Bauer, C., Baumeister, D., Blouw, J., Bulian, N., P. Fuchs, H., Hofmann, W., T. Knöpfle, K., Löchner, S., Ludwig, A., Schmelling, M., Schwingenheuer, B., Bachmann, S., Bock, P., Deppe, H., Eisele, F., Henneberger, S., Igo-Kemenes, P., Rusnyak, R., Stange, U., Trunk, U., Walter, M., Wiedner, D., Uwer, U., Kisel, I., Lindenstruth, V., W. Schulz, M., Bencivenni, G., Bloise, C., Bossi, F., Campana, P., Capon, G., De Simone, P., Forti, C., Lanfranchi, G., Murtas, F., Passalacqua, L., Patera, V., Poli-Lener, M., Sciubba, A., Avoni, G., Balbi, G., Bargiotti, M., Bertin, A., Bruschi, M., Carbone, A., De Castro, S., Faccioli, P., Fabbri, L., Galli, D., Giacobbe, B., Grimaldi, F., Lax, I., Marconi, U., Massa, I., Piccinini, M., Semprini-Cesari, N., Spighi, R., Vagnoni, V., Vecchi, S., Villa, M., Vitale, A., Zoccoli, A., Bonivento, W., Cadeddu, S., Cardini, A., De Leo, V., Deplano, C., Lai, A., Raspino, D., Saitta, B., Baldini, W., Carassiti, V., Cotta-Ramusino, A., Dalpiaz, P., Germani, S., Gianoli, A., Martini, M., Petrucci, F., Savrié, M., Bizzeti, A., Lenti, M., Lenzi, M., Passaleva, G., G. Pelfer, P., Veltri, M., Cuneo, S., Fontanelli, F., Gracco, V., Mini, G., Musico, P., Petrolini, A., Sannino, M., Bellunato, T., Calvi, M., Matteuzzi, C., Musy, M., Negri, P., Perego, D., Trentadue, L., Auriemma, G., Bocci, V., Bosio, C., Dane, E., Fidanza, D., Frenkel, A., Martellotti, G., Penso, G., Petrarca, S., Pinci, D., Pirozzi, G., Rinaldi, W., Santacesaria, R., Satriano, C., Satta, A., Carboni, G., De Capua, S., Domenici, D., Messi, R., Natali, G., Pacciani, L., Santovetti, E., Van Apeldoorn, G., Van Bakel, N., S. Bauer, T., Van Beuzekom, M., Van Den Brand, J.F.J., J. Bulten, H., Doets, M., Groep, D., Gromov, V., Hierck, R., Hommels, L., Van Hunen, J., Jans, E., Ketel, T., Klous, S., J. Kraan, M., Merk, M., Mul, F., Nardulli, J., Pellegrino, A., Raven, G., Schuijlenburg, H., Sluijk, T., Vankov, P., Van Tilburg J. Van, J., De Vries H. De, H., Wiggers, L., Zupan, E., Bisset, M., P. Cheng, J., G. Cui, Y., Dai, Y., Gao, Y., J. He, H., Huang, C., Jiang, C., P. Kuang, Y., Li, Q., J. Li, Y., Liao, Y., P. Ni, J., B. Shao, B., Su, J.J., R. Tian, Y., Wang, Q., S. Yan, Q., Ciba, K., Galuszka, K., Hajduk, L., Kapusta, P., Michalowski, J., Muryn, B., Natkaniec, Z., Oblakowska-Mucha, A., Polok, G., Stodulski, M., Witek, M., Zychowski, P., Adamus, M., Chlopik, A., Guzik, Z., Nawrot, A., Syryczynski, K., Szczekowski, M., Coca, C., Dima, O., Giolu, G., Magureanu, C., Orlandea, M., Popescu, S., Preda, T., M. Rosca, A., D. Tarta, P., Filippov, S., Gavrilov, J., Guschin, E., Kloubov, V., Kravchuk, L., Laptev, S., Laptev, V., Postoev, V., Rybkine, G., Sadovskii, A., Semeniouk, I., Strigin, V., Barsuk, S., Belyaev, I., Bobchenko, B., Dolgoshein, V., Golutvin, A., Gouchtchine, O., Kiritchenko, V., Kochetkov, V., Korolko, I., Pakhlova, G., Melnikov, E., Morozov, A., Pakhlov, P., Petriaev, A., Roussinov, D., Rusinov, V., Semenov, S., Shuvalov, S., Soldatov, A., Tarkovski, E., Beloborodov, K., Berdiouguine, A., Bondar, A., Bozhenok, A., Buzulutskov, A., Eidelman, S., Golubev, V., Krokovnyi, P., Oreshkin, S., Poluektov, A., Serednyakov, S., Shekhtman, L., Shwartz, B., Silagadze, Z., Vasilev, A., S. Belous, K., Brekhovskikh, V., I. Dzhelyadin, R., P. Guz, Y., Katchaev, I., Khmelnikov, V., Kisselev, V., Kobelev, A., K. Konoplyannikov, A., K. Likhoded, A., D. Matveev, V., Novikov, V., F. Obraztsov, V., P. Ostankov, A., Romanovski, V., I. Rykalin, V., M. Shapkin, M., Sokolov, A., M. Soldatov, M., V. Talanov, V., P. Yushchenko, O., Alkhazov, G., Andreev, V., Botchine, B., Ganja, V., Goloubev, V., Guetz, S., Kashchuk, A., Lazarev, V., Maev, E., Maev, O., Petrov, G., Saguidova, N., Sementchouk, G., Souvorov, V., Spiridenkov, E., Vorobyov, A., Vorobyov, An, Voropaev, N., Aguiló, E., Ballabriga, R., Calvo, M., Ferragut, S., Garrido, L., Gascón, D., Graciani-Díaz, R., Grauges Pous, E., Luengo, S., Peralta, D., Roselló, M., Vilasís, X., Adeva, B., Conde, P., Lois Gomez, C., Pazos, A., Pló, M., Saborido, J.J., Sanchez Garcia, M., Vasquez Regueiro, P., Bay, A., Carron, B., Dormond, O., Fernández, L., Frei, R., Haefeli, G., P. Hertig, J., Jacoby, C., Jalocha, P., Jimenez-Otero, S., Legger, F., Locatelli, L., Neufeld, N., P. Perroud, J., Ronga, F., Schietinger, T., Schneider, O., Studer, L., T. Tran, M., Villa, S., Voss, H., Bernet, R., P. Bernhard, R., Ermoline, Y., Gassner, J., Heule, St., Lehner, F., Needham, M., Sievers, P., Steiner, St., Steinkamp, O., Straumann, U., Vollhardt, A., Volyanski, D., Ziegler, M., Dovbnya, A., Ranyuk, Y., Shapoval, I., Aushev, V., Kiva, V., Kolomiets, I., Pavlenko, Y., Pugatch, V., Vasiliev, Y., H. Brook, N., D. Head, R., Muir, A., Phillips, A., Presland, A., F. Wilson, F., Buckley, A., George, K., Gibson, V., Harrison, K., R. Jones, C., G. Katvars, S., Storey, J., P. Ward, C., Wotton, S.A., J. Densham, C., Easo, S., Franek, B., G. V. Guy, J., N. J. Halsall, R., Kuznetsov, G., Loveridge, P., Morrow, D., V. Morris, J., Papanestis, A., N. Patrick, G., L. Woodward, M., Chamonal, R., Eisenhardt, S., Khan, A., Lawrence, J., Muheim, F., Playfer, S., Walker, A., G. Bates, A., Macgregor, A., O'Shea, V., Parkes, C., Pickford, A., Rahman, M., J. P. Soler, F., Biagi, S., Bowcock, T., Casse, G., Gamet, R., George, M., Hutchcroft, D., Palacios, J., Patel, G., Stavitskiy, I., Tobin, M., Washbrook, A., Allebone, L., J. Barber, G., Cameron, W., Clark, D., Dornan, P., Duane, A., Egede, U., Howard, A., Jolly, S., Plackett, R., R. Price, D., Savidge, T., M. Websdale, D., White, R., Adinolfi, M., H. Bibby, J., J. Charles, M., Cioffi, C., Damerell, G., Harnew, N., Harris, F., A. Mcarthur, I., Newby, C., Rademacker, J., Somerville, L., Soroko, A., J. Smale, N., Topp-Jørgensen, S., Wilkinson, G., Anelli, G., Anghinolfi, F., Arnaud, N., Bal, F., Barczyk, A., C. Batista Lopes, J., Benayoun, M., Bobillier, V., Braem, A., Buytaert, J., Campbell, M., Cattaneo, M., Charpentier, P., Christiansen, J., Closier, J., Collins, P., Corti, G., D'Ambrosio, C., Dijkstra, H., P. Dufey, J., Eckstein, D., Ferro-Luzzi, M., Flegel, W., Formenti, F., W. Forty, R., Frank, M., Frei, C., Gaspar, C., Gavillet, P., Guirao Elias, A., Gys, T., Hahn, F., Haider, S., Harvey, J., A. Hernando Morata, J., Van Herwijnen, E., J. Hilke, H., Jacobsson, R., Jarron, P., Joram, C., Jost, B., Köstner, S., Lacarrère, D., Letheren, M., Lippmann, C., Lindner, R., Losasso, M., Mato-Vila, P., Moritz, M., Müller, H., Nakada, T., Padilla, C., Parzefall, U., Pokorski, W., Ponce, S., Ranjard, F., Riegler, W., Aglieri Rinella, G., M. Rodrigues Figueiredo, E., Rodriguezde Llera Gonzalez, D., Roiser, S., Ruf, T., Ruiz Perez, H., Schmidt, B., Schneider, T., Schopper, A., Smith, A., Teubert, F., Tuning, N., Ullaland, O., Vannerem, P., Witzeling, W., Wyllie, K., Xie, Y., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), LHCb, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Pellet, Jeanine

Subjects
[PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detectors and Experimental Techniques
Published
2003

33. LHCb trigger system: Technical Design Report

Author

Antunes Nobrega, R., Franca Barbosa, A., Bediaga, I., Cernicchiaro, G., Correade Oliveira, E., Magnin, J., Marquesde Miranda, J., Massafferri, A., Polycarpo, E., Reis, A., Akiba, K., Amato, S., da Silva, T., de Mello-Neto, J.R.T., de Paula, B., de Paula, L., Gandelman, M., H. Lopes, J., Maréchal, B., Marinho, F., Moraes, D., Pelloux, N., Nunes, C., Perreira Nunes, C., Ballansat, J., Boget, D., Delebecque, P., de Bonis, I., Décamp, D., Drancourt, C., Dumont-Dayot, N., Girard, Christian, Lieunard, B., Minard, M.N., Pietrzyk, B., Terrier, H., Ajaltouni, Ziad, Bohner, G., Cârloganu, C., Cornat, R., Deschamps, O., Henrard, Pierre, Lecoq, J., Lefèvre, R., Monteil, S., Perret, Pascal, Rimbault, Cécile, Robert, A., Aslanides, E., P. Cachemiche, J., Dinkespiler, B., Y. Duval, P., Le Gac, R., Garonne, V., Leroy, O., L. Liotard, P., Menouni, M., Tsaregorodtsev, A., Viaud, B., Barrand, G., Beigbeder-Beau, C., Beneyton, R., Breton, D., Callot, O., Charlet, D., d'Almagne, B., Delcourt, B., Duarte, O., Fulda-Quenzer, F., Jean-Marie, B., Lefrançois, J., Machefert, F., Robbe, P., Schune, V., Tocut, M.H., Truong, K., Schwierz, R., Spaan, B., Agari, M., Bauer, C., Baumeister, D., Blouw, J., Bulian, N., P. Fuchs, H., Hofmann, W., T. Knöpfle, K., Löchner, S., Ludwig, A., Schmelling, M., Schwingenheuer, B., Bachmann, S., Bock, P., Deppe, H., Eisele, F., Henneberger, S., Igo-Kemenes, P., Rusnyak, R., Stange, U., Trunk, U., Walter, M., Wiedner, D., Uwer, U., Kisel, I., Lindenstruth, V., W. Schulz, M., Bencivenni, G., Bloise, C., Bossi, F., Campana, P., Capon, G., de Simone, P., Forti, C., Lanfranchi, G., Murtas, F., Passalacqua, L., Patera, V., Poli-Lener, M., Sciubba, A., Avoni, G., Balbi, G., Bargiotti, M., Bertin, A., Bruschi, M., Carbone, A., de Castro, S., Faccioli, P., Fabbri, L., Galli, D., Giacobbe, B., Grimaldi, F., Lax, I., Marconi, U., Massa, I., Piccinini, M., Semprini-Cesari, N., Spighi, R., Vagnoni, V., Vecchi, S., Villa, M., Vitale, A., Zoccoli, A., Bonivento, W., Cadeddu, S., Cardini, A., de Leo, V., Deplano, C., Lai, A., Raspino, D., Saitta, B., Baldini, W., Carassiti, V., Cotta-Ramusino, A., Dalpiaz, P., Germani, S., Gianoli, A., Martini, M., Petrucci, F., Savrié, M., Bizzeti, A., Lenti, M., Lenzi, M., Passaleva, G., G. Pelfer, P., Veltri, M., Cuneo, S., Fontanelli, F., Gracco, V., Mini, G., Musico, P., Petrolini, A., Sannino, M., Bellunato, T., Calvi, M., Matteuzzi, C., Musy, M., Negri, P., Perego, D., Trentadue, L., Auriemma, G., Bocci, V., Bosio, C., Dane, E., Fidanza, D., Frenkel, A., Martellotti, G., Penso, G., Petrarca, S., Pinci, D., Pirozzi, G., Rinaldi, W., Santacesaria, R., Satriano, C., Satta, A., Carboni, G., de Capua, S., Domenici, D., Messi, R., Natali, G., Pacciani, L., Santovetti, E., van Apeldoorn, G., van Bakel, N., S. Bauer, T., van Beuzekom, M., van den Brand, J.F.J., J. Bulten, H., Doets, M., Groep, D., Gromov, V., Hierck, R., Hommels, L., van Hunen, J., Jans, E., Ketel, T., Klous, S., J. Kraan, M., Merk, M., Mul, F., Nardulli, J., Pellegrino, A., Raven, G., Schuijlenburg, H., Sluijk, T., Vankov, P., van Tilburg J. Van, J., de Vries H. De, H., Wiggers, L., Zupan, E., Bisset, M., P. Cheng, J., G. Cui, Y., Dai, Y., Gao, Y., J. He, H., Huang, C., Jiang, C., P. Kuang, Y., Li, Q., J. Li, Y., Liao, Y., P. Ni, J., B. Shao, B., Su, J.J., R. Tian, Y., Wang, Q., S. Yan, Q., Ciba, K., Galuszka, K., Hajduk, L., Kapusta, P., Michalowski, J., Muryn, B., Natkaniec, Z., Oblakowska-Mucha, A., Polok, G., Stodulski, M., Witek, M., Zychowski, P., Adamus, M., Chlopik, A., Guzik, Z., Nawrot, A., Syryczynski, K., Szczekowski, M., Coca, C., Dima, O., Giolu, G., Magureanu, C., Orlandea, M., Popescu, S., Preda, T., M. Rosca, A., D. Tarta, P., Filippov, S., Gavrilov, J., Guschin, E., Kloubov, V., Kravchuk, L., Laptev, S., Laptev, V., Postoev, V., Rybkine, G., Sadovskii, A., Semeniouk, I., Strigin, V., Barsuk, S., Belyaev, I., Bobchenko, B., Dolgoshein, V., Golutvin, A., Gouchtchine, O., Kiritchenko, V., Kochetkov, V., Korolko, I., Pakhlova, G., Melnikov, E., Morozov, A., Pakhlov, P., Petriaev, A., Roussinov, D., Rusinov, V., Semenov, S., Shuvalov, S., Soldatov, A., Tarkovski, E., Beloborodov, K., Berdiouguine, A., Bondar, A., Bozhenok, A., Buzulutskov, A., Eidelman, S., Golubev, V., Krokovnyi, P., Oreshkin, S., Poluektov, A., Serednyakov, S., Shekhtman, L., Shwartz, B., Silagadze, Z., Vasilev, A., S. Belous, K., Brekhovskikh, V., I. Dzhelyadin, R., P. Guz, Y., Katchaev, I., Khmelnikov, V., Kisselev, V., Kobelev, A., K. Konoplyannikov, A., K. Likhoded, A., D. Matveev, V., Novikov, V., F. Obraztsov, V., P. Ostankov, A., Romanovski, V., I. Rykalin, V., M. Shapkin, M., Sokolov, A., M. Soldatov, M., V. Talanov, V., P. Yushchenko, O., Alkhazov, G., Andreev, V., Botchine, B., Ganja, V., Goloubev, V., Guetz, S., Kashchuk, A., Lazarev, V., Maev, E., Maev, O., Petrov, G., Saguidova, N., Sementchouk, G., Souvorov, V., Spiridenkov, E., Vorobyov, A., Vorobyov, An, Voropaev, N., Aguiló, E., Ballabriga, R., Calvo, M., Ferragut, S., Garrido, L., Gascón, D., Graciani-Díaz, R., Grauges Pous, E., Luengo, S., Peralta, D., Roselló, M., Vilasís, X., Adeva, B., Conde, P., Lois Gomez, C., Pazos, A., Pló, M., Saborido, J.J., Sanchez Garcia, M., Vasquez Regueiro, P., Bay, A., Carron, B., Dormond, O., Fernández, L., Frei, R., Haefeli, G., P. Hertig, J., Jacoby, C., Jalocha, P., Jimenez-Otero, S., Legger, F., Locatelli, L., Neufeld, N., P. Perroud, J., Ronga, F., Schietinger, T., Schneider, O., Studer, L., T. Tran, M., Villa, S., Voss, H., Bernet, R., P. Bernhard, R., Ermoline, Y., Gassner, J., Heule, St., Lehner, F., Needham, M., Sievers, P., Steiner, St., Steinkamp, O., Straumann, U., Vollhardt, A., Volyanski, D., Ziegler, M., Dovbnya, A., Ranyuk, Y., Shapoval, I., Aushev, V., Kiva, V., Kolomiets, I., Pavlenko, Y., Pugatch, V., Vasiliev, Y., H. Brook, N., D. Head, R., Muir, A., Phillips, A., Presland, A., F. Wilson, F., Buckley, A., George, K., Gibson, V., Harrison, K., R. Jones, C., G. Katvars, S., Storey, J., P. Ward, C., Wotton, S.A., J. Densham, C., Easo, S., Franek, B., G. V. Guy, J., N. J. Halsall, R., Kuznetsov, G., Loveridge, P., Morrow, D., V. Morris, J., Papanestis, A., N. Patrick, G., L. Woodward, M., Chamonal, R., Eisenhardt, S., Khan, A., Lawrence, J., Muheim, F., Playfer, S., Walker, A., G. Bates, A., Macgregor, A., O'Shea, V., Parkes, C., Pickford, A., Rahman, M., J. P. Soler, F., Biagi, S., Bowcock, T., Casse, G., Gamet, R., George, M., Hutchcroft, D., Palacios, J., Patel, G., Stavitskiy, I., Tobin, M., Washbrook, A., Allebone, L., J. Barber, G., Cameron, W., Clark, D., Dornan, P., Duane, A., Egede, U., Howard, A., Jolly, S., Plackett, R., R. Price, D., Savidge, T., M. Websdale, D., White, R., Adinolfi, M., H. Bibby, J., J. Charles, M., Cioffi, C., Damerell, G., Harnew, N., Harris, F., A. Mcarthur, I., Newby, C., Rademacker, J., Somerville, L., Soroko, A., J. Smale, N., Topp-Jørgensen, S., Wilkinson, G., Anelli, G., Anghinolfi, F., Arnaud, N., Bal, F., Barczyk, A., C. Batista Lopes, J., Benayoun, M., Bobillier, V., Braem, A., Buytaert, J., Campbell, M., Cattaneo, M., Charpentier, P., Christiansen, J., Closier, J., Collins, P., Corti, G., d'Ambrosio, C., Dijkstra, H., P. Dufey, J., Eckstein, D., Ferro-Luzzi, M., Flegel, W., Formenti, F., W. Forty, R., Frank, M., Frei, C., Gaspar, C., Gavillet, P., Guirao Elias, A., Gys, T., Hahn, F., Haider, S., Harvey, J., A. Hernando Morata, J., van Herwijnen, E., J. Hilke, H., Jacobsson, R., Jarron, P., Joram, C., Jost, B., Köstner, S., Lacarrère, D., Letheren, M., Lippmann, C., Lindner, R., Losasso, M., Mato-Vila, P., Moritz, M., Müller, H., Nakada, T., Padilla, C., Parzefall, U., Pokorski, W., Ponce, S., Ranjard, F., Riegler, W., Aglieri Rinella, G., M. Rodrigues Figueiredo, E., Rodriguezde Llera Gonzalez, D., Roiser, S., Ruf, T., Ruiz Perez, H., Schmidt, B., Schneider, T., Schopper, A., Smith, A., Teubert, F., Tuning, N., Ullaland, O., Vannerem, P., Witzeling, W., Wyllie, K., Xie, Y., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), LHCb, and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detectors and Experimental Techniques
Published
2003

37. The LHCb Detector at the LHC

Author

Collaboration, The LHCb, primary, Alves, A Augusto, additional, Filho, L M Andrade, additional, Barbosa, A F, additional, Bediaga, I, additional, Cernicchiaro, G, additional, Guerrer, G, additional, Lima, H P, additional, Machado, A A, additional, Magnin, J, additional, Marujo, F, additional, Miranda, J M de, additional, Reis, A, additional, Santos, A, additional, Toledo, A, additional, Akiba, K, additional, Amato, S, additional, Paula, B de, additional, Paula, L de, additional, Silva, T da, additional, Gandelman, M, additional, Lopes, J H, additional, Maréchal, B, additional, Moraes, D, additional, Polycarpo, E, additional, Rodrigues, F, additional, Ballansat, J, additional, Bastian, Y, additional, Boget, D, additional, Bonis, I De, additional, Coco, V, additional, David, P Y, additional, Decamp, D, additional, Delebecque, P, additional, Drancourt, C, additional, Dumont-Dayot, N, additional, Girard, C, additional, Lieunard, B, additional, Minard, M N, additional, Pietrzyk, B, additional, Rambure, T, additional, Rospabe, G, additional, T'Jampens, S, additional, Ajaltouni, Z, additional, Bohner, G, additional, Bonnefoy, R, additional, Borras, D, additional, Carloganu, C, additional, Chanal, H, additional, Conte, E, additional, Cornat, R, additional, Crouau, M, additional, Delage, E, additional, Deschamps, O, additional, Henrard, P, additional, Jacquet, P, additional, Lacan, C, additional, Laubser, J, additional, Lecoq, J, additional, Lefèvre, R, additional, Magne, M, additional, Martemiyanov, M, additional, Mercier, M-L, additional, Monteil, S, additional, Niess, V, additional, Perret, P, additional, Reinmuth, G, additional, Robert, A, additional, Suchorski, S, additional, Arnaud, K, additional, Aslanides, E, additional, Babel, J, additional, Benchouk, C, additional, Cachemiche, J-P, additional, Cogan, J, additional, Derue, F, additional, Dinkespiler, B, additional, Duval, P-Y, additional, Garonne, V, additional, Favard, S, additional, Gac, R Le, additional, Leon, F, additional, Leroy, O, additional, Liotard, P-L, additional, Marin, F, additional, Menouni, M, additional, Ollive, P, additional, Poss, S, additional, Roche, A, additional, Sapunov, M, additional, Tocco, L, additional, Viaud, B, additional, Tsaregorodtsev, A, additional, Amhis, Y, additional, Barrand, G, additional, Barsuk, S, additional, Beigbeder, C, additional, Beneyton, R, additional, Breton, D, additional, Callot, O, additional, Charlet, D, additional, D'Almagne, B, additional, Duarte, O, additional, Fulda-Quenzer, F, additional, Jacholkowska, A, additional, Jean-Marie, B, additional, Lefrancois, J, additional, Machefert, F, additional, Robbe, P, additional, Schune, M-H, additional, Tocut, V, additional, Videau, I, additional, Benayoun, M, additional, David, P, additional, Buono, L Del, additional, Gilles, G, additional, Domke, M, additional, Futterschneider, H, additional, Ilgner, Ch, additional, Kapusta, P, additional, Kolander, M, additional, Krause, R, additional, Lieng, M, additional, Nedos, M, additional, Rudloff, K, additional, Schleich, S, additional, Schwierz, R, additional, Spaan, B, additional, Wacker, K, additional, Warda, K, additional, Agari, M, additional, Bauer, C, additional, Baumeister, D, additional, Bulian, N, additional, Fuchs, H P, additional, Fallot-Burghardt, W, additional, Glebe, T, additional, Hofmann, W, additional, Knöpfle, K T, additional, Löchner, S, additional, Ludwig, A, additional, Maciuc, F, additional, Nieto, F Sanchez, additional, Schmelling, M, additional, Schwingenheuer, B, additional, Sexauer, E, additional, Smale, N J, additional, Trunk, U, additional, Voss, H, additional, Albrecht, J, additional, Bachmann, S, additional, Blouw, J, additional, Deissenroth, M, additional, Deppe, H, additional, Dreis, H B, additional, Eisele, F, additional, Haas, T, additional, Hansmann-Menzemer, S, additional, Hennenberger, S, additional, Knopf, J, additional, Moch, M, additional, Perieanu, A, additional, Rabenecker, S, additional, Rausch, A, additional, Rummel, C, additional, Rusnyak, R, additional, Schiller, M, additional, Stange, U, additional, Uwer, U, additional, Walter, M, additional, Ziegler, R, additional, Avoni, G, additional, Balbi, G, additional, Bonifazi, F, additional, Bortolotti, D, additional, Carbone, A, additional, D'Antone, I, additional, Galli, D, additional, Gregori, D, additional, Lax, I, additional, Marconi, U, additional, Peco, G, additional, Vagnoni, V, additional, Valenti, G, additional, Vecchi, S, additional, Bonivento, W, additional, Cardini, A, additional, Cadeddu, S, additional, DeLeo, V, additional, Deplano, C, additional, Furcas, S, additional, Lai, A, additional, Oldeman, R, additional, Raspino, D, additional, Saitta, B, additional, Serra, N, additional, Baldini, W, additional, Brusa, S, additional, Chiozzi, S, additional, Ramusino, A Cotta, additional, Evangelisti, F, additional, Franconieri, A, additional, Germani, S, additional, Gianoli, A, additional, Guoming, L, additional, Landi, L, additional, Malaguti, R, additional, Padoan, C, additional, Pennini, C, additional, Savriè, M, additional, Squerzanti, S, additional, Zhao, T, additional, Zhu, M, additional, Bizzeti, A, additional, Graziani, G, additional, Lenti, M, additional, Lenzi, M, additional, Maletta, F, additional, Pennazzi, S, additional, Passaleva, G, additional, Veltri, M, additional, Alfonsi, M, additional, Anelli, M, additional, Balla, A, additional, Battisti, A, additional, Bencivenni, G, additional, Campana, P, additional, Carletti, M, additional, Ciambrone, P, additional, Corradi, G, additional, Dané, E, additional, DiVirgilio, A, additional, DeSimone, P, additional, Felici, G, additional, Forti, C, additional, Gatta, M, additional, Lanfranchi, G, additional, Murtas, F, additional, Pistilli, M, additional, Lener, M Poli, additional, Rosellini, R, additional, Santoni, M, additional, Saputi, A, additional, Sarti, A, additional, Sciubba, A, additional, Zossi, A, additional, Ameri, M, additional, Cuneo, S, additional, Fontanelli, F, additional, Gracco, V, additional, Miní, G, additional, Parodi, M, additional, Petrolini, A, additional, Sannino, M, additional, Vinci, A, additional, Alemi, M, additional, Arnaboldi, C, additional, Bellunato, T, additional, Calvi, M, additional, Chignoli, F, additional, Lucia, A De, additional, Galotta, G, additional, Mazza, R, additional, Matteuzzi, C, additional, Musy, M, additional, Negri, P, additional, Perego, D, additional, Pessina, G, additional, Auriemma, G, additional, Bocci, V, additional, Buccheri, A, additional, Chiodi, G, additional, Marco, S Di, additional, Iacoangeli, F, additional, Martellotti, G, additional, Nobrega, R, additional, Pelosi, A, additional, Penso, G, additional, Pinci, D, additional, Rinaldi, W, additional, Rossi, A, additional, Santacesaria, R, additional, Satriano, C, additional, Carboni, G, additional, Iannilli, M, additional, Rodrigues, A Massafferri, additional, Messi, R, additional, Paoluzzi, G, additional, Sabatino, G, additional, Santovetti, E, additional, Satta, A, additional, Amoraal, J, additional, Apeldoorn, G van, additional, Arink, R, additional, Bakel, N van, additional, Band, H, additional, Bauer, Th, additional, Berkien, A, additional, Beuzekom, M van, additional, Bos, E, additional, Bron, Ch, additional, Ceelie, L, additional, Doets, M, additional, Eijk, R van der, additional, Fransen, J-P, additional, Groen, P de, additional, Gromov, V, additional, Hierck, R, additional, Homma, J, additional, Hommels, B, additional, Hoogland, W, additional, Jans, E, additional, Jansen, F, additional, Jansen, L, additional, Jaspers, M, additional, Kaan, B, additional, Koene, B, additional, Koopstra, J, additional, Kroes, F, additional, Kraan, M, additional, Langedijk, J, additional, Merk, M, additional, Mos, S, additional, Munneke, B, additional, Palacios, J, additional, Papadelis, A, additional, Pellegrino, A, additional, Petten, O van, additional, Pree, T du, additional, Roeland, E, additional, Ruckstuhl, W, additional, Schimmel, A, additional, Schuijlenburg, H, additional, Sluijk, T, additional, Spelt, J, additional, Stolte, J, additional, Terrier, H, additional, Tuning, N, additional, Lysebetten, A Van, additional, Vankov, P, additional, Verkooijen, J, additional, Verlaat, B, additional, Vink, W, additional, Vries, H de, additional, Wiggers, L, additional, Smit, G Ybeles, additional, Zaitsev, N, additional, Zupan, M, additional, Zwart, A, additional, Brand, J van den, additional, Bulten, H J, additional, Jong, M de, additional, Ketel, T, additional, Klous, S, additional, Kos, J, additional, M'charek, B, additional, Mul, F, additional, Raven, G, additional, Simioni, E, additional, Cheng, J, additional, Dai, G, additional, Deng, Z, additional, Gao, Y, additional, Gong, G, additional, Gong, H, additional, He, J, additional, Hou, L, additional, Li, J, additional, Qian, W, additional, Shao, B, additional, Xue, T, additional, Yang, Z, additional, Zeng, M, additional, Muryn, B, additional, Ciba, K, additional, Oblakowska-Mucha, A, additional, Blocki, J, additional, Galuszka, K, additional, Hajduk, L, additional, Michalowski, J, additional, Natkaniec, Z, additional, Polok, G, additional, Stodulski, M, additional, Witek, M, additional, Brzozowski, K, additional, Chlopik, A, additional, Gawor, P, additional, Guzik, Z, additional, Nawrot, A, additional, Srednicki, A, additional, Syryczynski, K, additional, Szczekowski, M, additional, Constantin, F, additional, Cristian, P, additional, Mihon, Gh, additional, Pavel, C, additional, Stoica, S, additional, Filippov, S, additional, Gavrilov, Yu, additional, Golyshkin, L, additional, Gushchin, E, additional, Karavichev, O, additional, Klubakov, V, additional, Kravchuk, L, additional, Kutuzov, V, additional, Laptev, S, additional, Popov, S, additional, Aref'ev, A, additional, Bobchenko, B, additional, Dolgoshein, V, additional, Egorychev, V, additional, Golutvin, A, additional, Gushchin, O, additional, Konoplyannikov, A, additional, Korolko, I, additional, Kvaratskheliya, T, additional, Machikhiliyan, I, additional, Malyshev, S, additional, Mayatskaya, E, additional, Prokudin, M, additional, Rusinov, D, additional, Rusinov, V, additional, Shatalov, P, additional, Shchutska, L, additional, Tarkovskiy, E, additional, Tayduganov, A, additional, Voronchev, K, additional, Zhiryakova, O, additional, Bobrov, A, additional, Bondar, A, additional, Eidelman, S, additional, Kozlinsky, A, additional, Shekhtman, L, additional, Beloous, K S, additional, Dzhelyadin, R I, additional, Gelitsky, Yu V, additional, Gouz, Yu P, additional, Kachnov, K G, additional, Kobelev, A S, additional, Matveev, V D, additional, Novikov, V P, additional, Obraztsov, V F, additional, Ostankov, A P, additional, Romanovsky, V I, additional, Rykalin, V I, additional, Soldatov, A P, additional, Soldatov, M M, additional, Tchernov, E N, additional, Yushchenko, O P, additional, Bochin, B, additional, Bondar, N, additional, Fedorov, O, additional, Golovtsov, V, additional, Guets, S, additional, Kashchuk, A, additional, Lazarev, V, additional, Maev, O, additional, Neustroev, P, additional, Sagidova, N, additional, Spiridenkov, E, additional, Volkov, S, additional, Vorobyev, An, additional, Vorobyov, A, additional, Aguilo, E, additional, Bota, S, additional, Calvo, M, additional, Comerma, A, additional, Cano, X, additional, Dieguez, A, additional, Herms, A, additional, Lopez, E, additional, Luengo, S, additional, Garra, J, additional, Garrido, Ll, additional, Gascon, D, additional, Valenzuela, A Gaspar de, additional, Gonzalez, C, additional, Graciani, R, additional, Grauges, E, additional, Calero, A Perez, additional, Picatoste, E, additional, Riera, J, additional, Rosello, M, additional, Ruiz, H, additional, Vilasis, X, additional, Xirgu, X, additional, Adeva, B, additional, Vidal, X Cid, additional, Santos, D MartÉnez, additional, Pereira, D Esperante, additional, Pazos, J L Fungueiriño, additional, Torreira, A Gallas, additional, Gómez, C Lois, additional, Alvarez, A Pazos, additional, Trigo, E Pérez, additional, Casasús, M Pló, additional, Cobo, C Rodriguez, additional, Pérez, P Rodríguez, additional, Saborido, J J, additional, Seco, M, additional, Regueiro, P Vazquez, additional, Bartalini, P, additional, Bay, A, additional, Bettler, M-O, additional, Blanc, F, additional, Borel, J, additional, Carron, B, additional, Currat, C, additional, Conti, G, additional, Dormond, O, additional, Ermoline, Y, additional, Fauland, P, additional, Fernandez, L, additional, Frei, R, additional, Gagliardi, G, additional, Gueissaz, N, additional, Haefeli, G, additional, Hicheur, A, additional, Jacoby, C, additional, Jalocha, P, additional, Jimenez-Otero, S, additional, Hertig, J-P, additional, Knecht, M, additional, Legger, F, additional, Locatelli, L, additional, Moser, J-R, additional, Needham, M, additional, Nicolas, L, additional, Perrin-Giacomin, A, additional, Perroud, J-P, additional, Potterat, C, additional, Ronga, F, additional, Schneider, O, additional, Schietinger, T, additional, Steele, D, additional, Studer, L, additional, Tareb, M, additional, Tran, M T, additional, Hunen, J van, additional, Vervink, K, additional, Villa, S, additional, Zwahlen, N, additional, Bernet, R, additional, Büchler, A, additional, Gassner, J, additional, Lehner, F, additional, Sakhelashvili, T, additional, Salzmann, C, additional, Sievers, P, additional, Steiner, S, additional, Steinkamp, O, additional, Straumann, U, additional, Tilburg, J van, additional, Vollhardt, A, additional, Volyanskyy, D, additional, Ziegler, M, additional, Dovbnya, A, additional, Ranyuk, Yu, additional, Shapoval, I, additional, Borisova, M, additional, Iakovenko, V, additional, Kyva, V, additional, Kovalchuk, O, additional, Okhrimenko, O, additional, Pugatch, V, additional, Pylypchenko, Yu, additional, Adinolfi, M, additional, Brook, N H, additional, Head, R D, additional, Imong, J P, additional, Lessnoff, K A, additional, Metlica, F C D, additional, Muir, A J, additional, Rademacker, J H, additional, Solomin, A, additional, Szczypka, P M, additional, Barham, C, additional, Buszello, C, additional, Dickens, J, additional, Gibson, V, additional, Haines, S, additional, Harrison, K, additional, Jones, C R, additional, Katvars, S, additional, Kerzel, U, additional, Lazzeroni, C, additional, Li, Y Y, additional, Rogers, G, additional, Storey, J, additional, Skottowe, H, additional, Wotton, S A, additional, Adye, T J, additional, Densham, C J, additional, Easo, S, additional, Franek, B, additional, Loveridge, P, additional, Morrow, D, additional, Morris, J V, additional, Nandakumar, R, additional, Nardulli, J, additional, Papanestis, A, additional, Patrick, G N, additional, Ricciardi, S, additional, Woodward, M L, additional, Zhang, Z, additional, Chamonal, R J U, additional, Clark, P J, additional, Clarke, P, additional, Eisenhardt, S, additional, Gilardi, N, additional, Khan, A, additional, Kim, Y M, additional, Lambert, R, additional, Lawrence, J, additional, Main, A, additional, McCarron, J, additional, Mclean, C, additional, Muheim, F, additional, Osorio-Oliveros, A F, additional, Playfer, S, additional, Styles, N, additional, Xie, Y, additional, Bates, A, additional, Carson, L, additional, Marinho, F da Cunha, additional, Doherty, F, additional, Eklund, L, additional, Gersabeck, M, additional, Haddad, L, additional, Macgregor, A A, additional, Melone, J, additional, McEwan, F, additional, Petrie, D M, additional, Paterson, S K, additional, Parkes, C, additional, Pickford, A, additional, Rakotomiaramanana, B, additional, Rodrigues, E, additional, Saavedra, A F, additional, Soler, F J P, additional, Szumlak, T, additional, Viret, S, additional, Allebone, L, additional, Awunor, O, additional, Back, J, additional, Barber, G, additional, Barnes, C, additional, Cameron, B, additional, Clark, D, additional, Clark, I, additional, Dornan, P, additional, Duane, A, additional, Eames, C, additional, Egede, U, additional, Girone, M, additional, Greenwood, S, additional, Hallam, R, additional, Hare, R, additional, Howard, A, additional, Jolly, S, additional, Kasey, V, additional, Khaleeq, M, additional, Koppenburg, P, additional, Miller, D, additional, Plackett, R, additional, Price, D, additional, Reece, W, additional, Savage, P, additional, Savidge, T, additional, Simmons, B, additional, Vidal-Sitjes, G, additional, Websdale, D, additional, Affolder, A, additional, Anderson, J S, additional, Biagi, S F, additional, Bowcock, T J V, additional, Carroll, J L, additional, Casse, G, additional, Cooke, P, additional, Donleavy, S, additional, Dwyer, L, additional, Hennessy, K, additional, Huse, T, additional, Hutchcroft, D, additional, Jones, D, additional, Lockwood, M, additional, McCubbin, M, additional, McNulty, R, additional, Muskett, D, additional, Noor, A, additional, Patel, G D, additional, Rinnert, K, additional, Shears, T, additional, Smith, N A, additional, Southern, G, additional, Stavitski, I, additional, Sutcliffe, P, additional, Tobin, M, additional, Traynor, S M, additional, Turner, P, additional, Whitley, M, additional, Wormald, M, additional, Wright, V, additional, Bibby, J H, additional, Brisbane, S, additional, Brock, M, additional, Charles, M, additional, Cioffi, C, additional, Gligorov, V V, additional, Handford, T, additional, Harnew, N, additional, Harris, F, additional, John, M J J, additional, Jones, M, additional, Libby, J, additional, Martin, L, additional, McArthur, I A, additional, Muresan, R, additional, Newby, C, additional, Ottewell, B, additional, Powell, A, additional, Rotolo, N, additional, Senanayake, R S, additional, Somerville, L, additional, Soroko, A, additional, Spradlin, P, additional, Sullivan, P, additional, Stokes-Rees, I, additional, Topp-Jorgensen, S, additional, Xing, F, additional, Wilkinson, G, additional, Artuso, M, additional, Belyaev, I, additional, Blusk, S, additional, Lefeuvre, G, additional, Menaa, N, additional, Menaa-Sia, R, additional, Mountain, R, additional, Skwarnicki, T, additional, Stone, S, additional, Wang, J C, additional, Abadie, L, additional, Aglieri-Rinella, G, additional, Albrecht, E, additional, André, J, additional, Anelli, G, additional, Arnaud, N, additional, Augustinus, A, additional, Bal, F, additional, Pazos, M C Barandela, additional, Barczyk, A, additional, Bargiotti, M, additional, Lopes, J Batista, additional, Behrendt, O, additional, Berni, S, additional, Binko, P, additional, Bobillier, V, additional, Braem, A, additional, Brarda, L, additional, Buytaert, J, additional, Camilleri, L, additional, Cambpell, M, additional, Castellani, G, additional, Cataneo, F, additional, Cattaneo, M, additional, Chadaj, B, additional, Charpentier, P, additional, Cherukuwada, S, additional, Chesi, E, additional, Christiansen, J, additional, Chytracek, R, additional, Clemencic, M, additional, Closier, J, additional, Collins, P, additional, Colrain, P, additional, Cooke, O, additional, Corajod, B, additional, Corti, G, additional, D'Ambrosio, C, additional, Damodaran, B, additional, David, C, additional, Capua, S de, additional, Decreuse, G, additional, Degaudenzi, H, additional, Dijkstra, H, additional, Droulez, J-P, additional, Ramos, D Duarte, additional, Dufey, J P, additional, Dumps, R, additional, Eckstein, D, additional, Ferro-Luzzi, M, additional, Fiedler, F, additional, Filthaut, F, additional, Flegel, W, additional, Forty, R, additional, Fournier, C, additional, Frank, M, additional, Frei, C, additional, Gaidioz, B, additional, Gaspar, C, additional, Gayde, J-C, additional, Gavillet, P, additional, Go, A, additional, Abril, G Gracia, additional, Graulich, J-S, additional, Giudici, P-A, additional, Elias, A Guirao, additional, Guglielmini, P, additional, Gys, T, additional, Hahn, F, additional, Haider, S, additional, Harvey, J, additional, Hay, B, additional, Morata, J-A Hernando, additional, Alvarez, J Herranz, additional, Herwijnen, E van, additional, Hilke, H J, additional, Holtey, G von, additional, Hulsbergen, W, additional, Jacobsson, R, additional, Jamet, O, additional, Joram, C, additional, Jost, B, additional, Kanaya, N, additional, Refolio, J Knaster, additional, Koestner, S, additional, Koratzinos, M, additional, Kristic, R, additional, Lacarrère, D, additional, Lasseur, C, additional, Lastovicka, T, additional, Laub, M, additional, Liko, D, additional, Lippmann, C, additional, Lindner, R, additional, Losasso, M, additional, Maier, A, additional, Mair, K, additional, Maley, P, additional, Vila, P Mato, additional, Moine, G, additional, Morant, J, additional, Moritz, M, additional, Moscicki, J, additional, Muecke, M, additional, Mueller, H, additional, Nakada, T, additional, Neufeld, N, additional, Ocariz, J, additional, Aranda, C Padilla, additional, Parzefall, U, additional, Patel, M, additional, Pepe-Altarelli, M, additional, Piedigrossi, D, additional, Pivk, M, additional, Pokorski, W, additional, Ponce, S, additional, Ranjard, F, additional, Riegler, W, additional, Renaud, J, additional, Roiser, S, additional, Roy, L, additional, Ruf, T, additional, Ruffinoni, D, additional, Saladino, S, additional, Varela, A Sambade, additional, Santinelli, R, additional, Schmelling, S, additional, Schmidt, B, additional, Schneider, T, additional, Schöning, A, additional, Schopper, A, additional, Seguinot, J, additional, Snoeys, W, additional, Smith, A, additional, Smith, A C, additional, Somogyi, P, additional, Stoica, R, additional, Tejessy, W, additional, Teubert, F, additional, Thomas, E, additional, Alarcon, J Toledo, additional, Ullaland, O, additional, Valassi, A, additional, Vannerem, P, additional, Veness, R, additional, Wicht, P, additional, Wiedner, D, additional, Witzeling, W, additional, Wright, A, additional, Wyllie, K, additional, and Ypsilantis, T, additional

Published
2008
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38. The LHCb computing data challenge DC06

Author

Nandakumar, R, primary, Jimenez, S G, additional, Adinolfi, M, additional, Bernet, R, additional, Blouw, J, additional, Bortolotti, D, additional, Carbone, A, additional, M'Charek, B, additional, Perego, D L, additional, Pickford, A, additional, Potterat, C, additional, Miguelez, M S, additional, Bargiotti, M, additional, Brook, N, additional, Casajus, A, additional, Castellani, G, additional, Charpentier, P, additional, Cioffi, C, additional, Closier, J, additional, Diaz, R Graciani, additional, Kuznetsov, G, additional, Paterson, S, additional, Santinelli, R, additional, Smith, A C, additional, and Tsaregorotsev, A, additional

Published
2008
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39. DIRAC: a community grid solution

Author

Tsaregorodtsev, A, primary, Bargiotti, M, additional, Brook, N, additional, Ramo, A C, additional, Castellani, G, additional, Charpentier, P, additional, Cioffi, C, additional, Closier, J, additional, Diaz, R G, additional, Kuznetsov, G, additional, Li, Y Y, additional, Nandakumar, R, additional, Paterson, S, additional, Santinelli, R, additional, Smith, A C, additional, Miguelez, M S, additional, and Jimenez, S G, additional

Published
2008
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40. GridPP: development of the UK computing Grid for particle physics

Author

Collaboration, The GridPP, primary, Faulkner, P J W, additional, Lowe, L S, additional, Tan, C L A, additional, Watkins, P M, additional, Bailey, D S, additional, Barrass, T A, additional, Brook, N H, additional, Croft, R J H, additional, Kelly, M P, additional, Mackay, C K, additional, Metson, S, additional, Maroney, O J E, additional, Newbold, D M, additional, Wilson, F F, additional, Hobson, P R, additional, Khan, A, additional, Kyberd, P, additional, Nebrensky, J J, additional, Bly, M, additional, Brew, C, additional, Burke, S, additional, Byrom, R, additional, Coles, J, additional, Cornwall, L A, additional, Djaoui, A, additional, Field, L, additional, Fisher, S M, additional, Folkes, G T, additional, Geddes, N I, additional, Gordon, J C, additional, Hicks, S J C, additional, Jensen, J G, additional, Johnson, G, additional, Kant, D, additional, Kelsey, D P, additional, Kuznetsov, G, additional, Leake, J, additional, Middleton, R P, additional, Patrick, G N, additional, Prassas, G, additional, Saunders, B J, additional, Ross, D, additional, Sansum, R A, additional, Shah, T, additional, Strong, B, additional, Synge, O, additional, Tam, R, additional, Thorpe, M, additional, Traylen, S, additional, Wheeler, J F, additional, White, N G H, additional, Wilson, A J, additional, Antcheva, I, additional, Artiaga, E, additional, Beringer, J, additional, Bird, I G, additional, Casey, J, additional, Cass, A J, additional, Chytracek, R, additional, Torreira, M V Gallas, additional, Generowicz, J, additional, Girone, M, additional, Govi, G, additional, Harris, F, additional, Heikkurinen, M, additional, Horvath, A, additional, Knezo, E, additional, Litmaath, M, additional, Lubeck, M, additional, Moscicki, J, additional, Neilson, I, additional, Poinsignon, E, additional, Pokorski, W, additional, Ribon, A, additional, Sekera, Z, additional, Smith, D H, additional, Tomlin, W L, additional, Eldik, J E van, additional, Wojcieszuk, J, additional, Brochu, F M, additional, Das, S, additional, Harrison, K, additional, Hayes, M, additional, Hill, J C, additional, Lester, C G, additional, Palmer, M J, additional, Parker, M A, additional, Nelson, M, additional, Whalley, M R, additional, Glover, E W N, additional, Anderson, P, additional, Clark, P J, additional, Earl, A D, additional, Holt, A, additional, Jackson, A, additional, Joo, B, additional, Kenway, R D, additional, Maynard, C M, additional, Perry, J, additional, Smith, L, additional, Thorn, S, additional, Trew, A S, additional, Bell, W H, additional, Burgon-Lyon, M, additional, Cameron, D G, additional, Doyle, A T, additional, Flavell, A, additional, Hanlon, S J, additional, Martin, D J, additional, McCance, G, additional, Millar, A P, additional, Nicholson, C, additional, Paterson, S K, additional, Pickford, A, additional, Soler, P, additional, Speirs, F, additional, Denis, R St, additional, Thompson, A S, additional, Britton, D, additional, Cameron, W, additional, Colling, D, additional, Davies, G, additional, Dornan, P, additional, Egede, U, additional, Georgiou, K, additional, Lewis, P, additional, MacEvoy, B, additional, Marr, S, additional, Martyniak, J, additional, Tallini, H, additional, Wakefield, S, additional, Walker, R, additional, Bertram, I A, additional, Bouhova-Thacker, E, additional, Evans, D, additional, Henderson, R C W, additional, Jones, R W L, additional, Love, P, additional, Downing, S, additional, George, M P, additional, Irving, A C, additional, McNeile, C, additional, Sroczynski, Z, additional, Tobin, M, additional, Washbrook, A J, additional, Barlow, R J, additional, Dallison, S, additional, Fairey, G, additional, Forti, A, additional, Hughes-Jones, R E, additional, Jones, M A S, additional, Kaushal, S, additional, Marshall, R, additional, McNab, A, additional, Salih, S, additional, Werner, J C, additional, Bartsch, V, additional, Cioffi, C, additional, Gronbech, P, additional, Harnew, N, additional, Harris, J F, additional, Huffman, B T, additional, Leslie, M, additional, McArthur, I, additional, Newman, R, additional, Soroko, A, additional, Stokes-Rees, I, additional, Stonjek, S, additional, Tseng, J, additional, Waters, D, additional, Wilkinson, G, additional, Arter, T R, additional, Cordenonsi, R A, additional, Datta, A S, additional, Hartin, T, additional, Lloyd, S L, additional, Martin, A J, additional, Pearce, S E, additional, Williams, C J, additional, Gardner, M, additional, George, S, additional, Green, B J, additional, Johal, S, additional, Rybkine, G, additional, Strong, J A, additional, Teixeira-Dias, P, additional, Hodgson, P, additional, Robinson, M, additional, Tovey, D R, additional, Spooner, N J C, additional, Allton, C R, additional, Armour, W, additional, Clarke, P, additional, Mealor, P, additional, Waugh, B, additional, and West, B, additional

Published
2005
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42. Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

Author

Ran Jin, Rob McConnell, Cioffi Catherine, Shujing Xu, Douglas I. Walker, Nikos Stratakis, Dean P. Jones, Gary W. Miller, Cheng Peng, David V. Conti, Miriam B. Vos, and Leda Chatzi

Subjects
Environmental sciences, GE1-350
Abstract

Background: Toxicant-associated steatohepatitis has been described in adults but less is known regarding the role of toxicants in liver disease of children. Perfluoroalkyl substances (PFAS) cause hepatic steatosis in rodents, but few previous studies have examined PFAS effects on severity of liver injury in children. Objectives: We aimed to examine the relationship of PFAS to histologic severity of nonalcoholic fatty liver disease (NAFLD) in children. Methods: Seventy-four children with physician-diagnosed NAFLD were recruited from Children’s Healthcare of Atlanta between 2007 and 2015. Biopsy-based liver histological features were scored for steatosis, lobular and portal inflammation, ballooning, and fibrosis. Plasma concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonic acid (PFHxS), and untargeted plasma metabolomic profiling, were determined using liquid chromatography with high-resolution mass spectrometry. A metabolome-wide association study coupled with pathway enrichment analysis was performed to evaluate metabolic dysregulation associated with PFAS. A structural integrated analysis was applied to identify latent clusters of children with more severe form of NAFLD based on their PFAS levels and metabolite pattern. Results: Patients were 7–19 years old, mostly boys (71%), Hispanic (51%), and obese (85%). The odds of having nonalcoholic steatohepatitis (NASH), compared to children with steatosis alone, was significantly increased with each interquartile range (IQR) increase of PFOS (OR: 3.32, 95% CI: 1.40–7.87) and PFHxS (OR: 4.18, 95% CI: 1.64–10.7). Each IQR increase of PFHxS was associated with increased odds for liver fibrosis (OR: 4.44, 95% CI: 1.34–14.8), lobular inflammation (OR: 2.87, 95% CI: 1.12–7.31), and higher NAFLD activity score (β coefficient 0.46; 95% CI: 0.03, 0.89). A novel integrative analysis identified a cluster of children with NASH, characterized by increased PFAS levels and altered metabolite patterns including higher plasma levels of phosphoethanolamine, tyrosine, phenylalanine, aspartate and creatine, and decreased plasma levels of betaine. Conclusions: Ηigher PFAS exposure was associated with more severe disease in children with NAFLD. PFAS may be an important toxicant contributing to NAFLD progression; however larger, longitudinal studies are warranted to confirm these findings.

Published
2020
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45. GridPP: development of the UK computing Grid for particle physics

Author

Collaboration, The TGC, Faulkner, P PJW W, Lowe, L LSL, Tan, C CLA A, Watkins, P PMW, Bailey, D DSB, Barrass, T TAB, Brook, N NHB, Croft, R RJH H, Kelly, M MPK, Mackay, C CKM, Metson, S SM, Maroney, O OJE E, Newbold, D DMN, Wilson, F FFW, Hobson, P PRH, Khan, A AK, Kyberd, P PK, Nebrensky, J JJN, Bly, M MB, Brew, C CB, Burke, S SB, Byrom, R RB, Coles, J JC, Cornwall, L LAC, Djaoui, A AD, Field, L LF, Fisher, S SMF, Folkes, G GTF, Geddes, N NIG, Gordon, J JCG, Hicks, S SJC C, Jensen, J JGJ, Johnson, G GJ, Kant, D DK, Kelsey, D DPK, Kuznetsov, G GK, Leake, J JL, Middleton, R RPM, Patrick, G GNP, Prassas, G GP, Saunders, B BJS, Ross, D DR, Sansum, R RAS, Shah, T TS, Strong, B BS, Synge, O OS, Tam, R RT, Thorpe, M MT, Traylen, S ST, Wheeler, J JFW, White, N NGH H, Wilson, A AJW, Antcheva, I IA, Artiaga, E EA, Beringer, J JB, Bird, I IGB, Casey, J JC, Cass, A AJC, Chytracek, R RC, Torreira, M MVG Gallas, Generowicz, J JG, Girone, M MG, Govi, G GG, Harris, F FH, Heikkurinen, M MH, Horvath, A AH, Knezo, E EK, Litmaath, M ML, Lubeck, M ML, Moscicki, J JM, Neilson, I IN, Poinsignon, E EP, Pokorski, W WP, Ribon, A AR, Sekera, Z ZS, Smith, D DHS, Tomlin, W WLT, Eldik, J JEv van, Wojcieszuk, J JW, Brochu, F FMB, Das, S SD, Harrison, K KH, Hayes, M MH, Hill, J JCH, Lester, C CGL, Palmer, M MJP, Parker, M MAP, Nelson, M MN, Whalley, M MRW, Glover, E EWN N, Anderson, P PA, Clark, P PJC, Earl, A ADE, Holt, A AH, Jackson, A AJ, Joo, B BJ, Kenway, R RDK, Maynard, C CMM, Perry, J JP, Smith, L LS, Thorn, S ST, Trew, A AST, Bell, W WHB, Burgon-Lyon, M MB, Cameron, D DGC, Doyle, A ATD, Flavell, A AF, Hanlon, S SJH, Martin, D DJM, McCance, G GM, Millar, A APM, Nicholson, C CN, Paterson, S SKP, Pickford, A AP, Soler, P PS, Speirs, F FS, Denis, R RSD, Thompson, A AST, Britton, D DB, Cameron, W WC, Colling, D DC, Davies, G GD, Dornan, P PD, Egede, U UE, Georgiou, K KG, Lewis, P PL, MacEvoy, B BM, Marr, S SM, Martyniak, J JM, Tallini, H HT, Wakefield, S SW, Walker, R RW, Bertram, I IAB, Bouhova-Thacker, E EB, Evans, D DE, Henderson, R RCW W, Jones, R RWL L, Love, P PL, Downing, S SD, George, M MPG, Irving, A ACI, McNeile, C CM, Sroczynski, Z ZS, Tobin, M MT, Washbrook, A AJW, Barlow, R RJB, Dallison, S SD, Fairey, G GF, Forti, A AF, Hughes-Jones, R REH, Jones, M MAS S, Kaushal, S SK, Marshall, R RM, McNab, A AM, Salih, S SS, Werner, J JCW, Bartsch, V VB, Cioffi, C CC, Gronbech, P PG, Harnew, N NH, Harris, J JFH, Huffman, B BTH, Leslie, M ML, McArthur, I IM, Newman, R RN, Soroko, A AS, Stokes-Rees, I IS, Stonjek, S SS, Tseng, J JT, Waters, D DW, Wilkinson, G GW, Arter, T TRA, Cordenonsi, R RAC, Datta, A ASD, Hartin, T TH, Lloyd, S SLL, Martin, A AJM, Pearce, S SEP, Williams, C CJW, Gardner, M MG, George, S SG, Green, B BJG, Johal, S SJ, Rybkine, G GR, Strong, J JAS, Teixeira-Dias, P PT, Hodgson, P PH, Robinson, M MR, Tovey, D DRT, Spooner, N NJC C, Allton, C CRA, Armour, W WA, Clarke, P PC, Mealor, P PM, Waters, D DW, Waugh, B BW, and West, B BW

Abstract

The GridPP Collaboration is building a UK computing Grid for particle physics, as part of the international effort towards computing for the Large Hadron Collider. The project, funded by the UK Particle Physics and Astronomy Research Council (PPARC), began in September 2001 and completed its first phase 3 years later. GridPP is a collaboration of approximately 100 researchers in 19 UK university particle physics groups, the Council for the Central Laboratory of the Research Councils and CERN, reflecting the strategic importance of the project. In collaboration with other European and US efforts, the first phase of the project demonstrated the feasibility of developing, deploying and operating a Grid-based computing system to meet the UK needs of the Large Hadron Collider experiments. This note describes the work undertaken to achieve this goal.

Published
2006

46. Syntheses and Opioid Receptor Binding Affinities of 8-Amino-2,6-methano-3-benzazocines

Author

Wentland, M. P., Ye, Y., Cioffi, C. L., Lou, R., Zhou, Q., Xu, G., Duan, W., Dehnhardt, C. M., Sun, X., Cohen, D. J., and Bidlack, J. M.

Abstract

8-Amino-2,6-methano-3-benzazocine derivatives have been made using Pd-catalyzed amination procedures, and their affinities for opioid receptors were assessed. The 8-amino group was hypothesized to be a replacement for the prototypic 8-OH substituent for 2,6-methano-3-benzazocines and related opiates. This OH group is generally required for binding yet is implicated in unfavorable pharmacokinetic characteristics such as low oral bioavailability and rapid clearance via O-glucuronidation. The core structures in which the 8-OH group was replaced were cyclazocine and its enantiomers, ethylketocyclazocine and its enantiomers, ketocyclazocine, and Mr2034. Many new analogues had high affinity for opioid receptors with several in the subnanomolar range. Highest affinity was seen in analogues with secondary 8-(hetero)arylamino appendages. Binding to opioid receptors was enantioselective with the (2R,6R,11R)-configuration preferred and high selectivity for μ and κ over δ opioid receptors was observed within the series. Several derivatives were shown to have intrinsic opioid-receptor-mediated activity in [35S]GTPγS assays.

Published
2003
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47. An IgH enhancer that drives transcription through basic helix-loop-helix and Oct transcription factor binding motifs. Functional analysis of the E(mu)3' enhancer of the catfish.

Author

Cioffi, C C, Middleton, D L, Wilson, M R, Miller, N W, Clem, L W, and Warr, G W

Abstract

The transcriptional enhancer (E(mu)3') of the IgH locus of the channel catfish, Ictalurus punctatus, shows strong B cell-specific activity and differs from the mammalian E(mu) enhancer in both location and structure. It occurs between the mu and delta genes and contains numerous transcription factor binding sites, predominantly octamer and muE5 motifs of consensus and variant sequences. It lacks the classical muA-muE3(CBF)-muB core array of binding motifs seen within mammalian IgH E(mu) enhancers. To determine the functionally important motifs, a series of mutant enhancers was created using sequence-targeted polymerase chain reaction. Whereas the mutation of consensus and variant octamer motifs (individually or in multiples) decreased enhancer function, mutation of a single consensus muE5 motif destroyed the function of this enhancer in mammalian plasmacytomas. Mutation of this consensus muE5 site, combined with mutations of certain octamer sites, destroyed function in catfish B cells. Experiments using artificial enhancers containing multimers of motifs or short regions of the native enhancer suggested that the minimal E(mu)3' enhancer (a) contains a consensus muE5 site and two octamer sites, (b) is B cell-specific, and (c) is active across species. The dependence of an Ig enhancer on sites that bind basic helix-loop-helix and Oct transcription factors has not previously been observed and confirms large differences in structure and function between fish and mammalian IgH enhancers.

Published
2001
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48. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes.

Author

D, Hreniuk, M, Garay, W, Gaarde, P, Monia B, A, McKay R, and L, Cioffi C

Abstract

In the present study, rat cardiac myocytes were used as an in vitro ischemia/reperfusion injury model to delineate the role of c-Jun N-terminal kinase (JNK) 1 and JNK2 isoforms in ischemia/reoxygenation-induced apoptosis using an antisense approach. Exposure of rat cardiac myocytes to ischemia did not induce apoptosis as detected by staining with either acridine orange/ethidium bromide or annexin-V-fluorescein/propidium iodide. In contrast, a time-dependent increase in the number of apoptotic cells was noted after reoxygenation of ischemic myocytes, whereas the level of necrotic cells remained unaltered. Reoxygenation, but not ischemia alone, also caused a time-dependent increase in JNK activation that preceded apoptosis induction. Treatment of cardiac myocytes with antisense (AS) oligonucleotides that specifically targeted either JNK1 or JNK2 significantly reduced both mRNA and protein expression of the target isoform but had no effect on the expression of the alternate isoform. Pretreatment of cardiac myocytes with JNK1 AS, but not JNK2 AS, resulted in almost complete attenuation of reoxygenation-induced apoptosis. Furthermore, control oligonucleotides for JNK1 AS or JNK2 AS had no effect on JNK mRNA or protein expression or reoxygenation-induced apoptosis, indicating a sequence-specific mode of action. Additional studies revealed that apoptosis induced by other JNK-activating stimuli, including ceramide, heat shock, and UV irradiation, was partly suppressed after treatment with JNK1 AS but not JNK2 AS. These findings demonstrate that the JNK1 isoform plays a preferential role in apoptosis induced by ischemia/reoxygenation as well as diverse JNK-activating cellular stresses.

Published
2001

49. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

Author

E, Buchdunger, L, Cioffi C, N, Law, D, Stover, S, Ohno-Jones, J, Druker B, and B, Lydon N

Abstract

STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the treatment of chronic myelogenous leukemia. STI571 selectively inhibits the Abl and platelet-derived growth factor (PDGF) receptor tyrosine kinases in vitro and blocks cellular proliferation and tumor growth of Bcr-abl- or v-abl-expressing cells. We have further investigated the profile of STI571 against related receptor tyrosine kinases. STI571 was found to potently inhibit the kinase activity of the alpha- and beta-PDGF receptors and the receptor for stem cell factor, but not the closely related c-Fms, Flt-3, Kdr, Flt-1, and Tek tyrosine kinases. Additionally, no inhibition of c-Met or nonreceptor tyrosine kinases such as Src and Jak-2 has been observed. In cell-based assays, STI571 selectively inhibited PDGF and stem cell factor-mediated cellular signaling, including ligand-stimulated receptor autophosphorylation, inositol phosphate formation, and mitogen-activated protein kinase activation and proliferation. These results expand the profile of STI571 and suggest that in addition to chronic myelogenous leukemia, STI571 may have clinical potential in the treatment of diseases that involve abnormal activation of c-Kit or PDGF receptor tyrosine kinases.

Published
2000

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