1. Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer
- Author
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Chun Feng Xin, Gamin Kim, Seyeon Park, Jahirul Islam, Hong In Yoon, Sang Uk Seo, Su Myeong Park, Je In Youn, Soonmyung Paik, Sang Jun Ha, Bumseo Baik, Hee Jae Lee, Inkyung Jung, Byoung Chul Cho, Hyun Tak Jin, Aziz Ghaderpour, Eun Young Lee, Jimin Son, Hye Ryun Kim, Ji Woong Choi, Min Hee Hong, Hang Rae Kim, and Seung Yong Seong
- Subjects
Adult ,Male ,Lung Neoplasms ,T-Lymphocytes ,medicine.medical_treatment ,Programmed Cell Death 1 Receptor ,Cell ,Population ,lcsh:Medicine ,Article ,Carcinoma, Non-Small-Cell Lung ,medicine ,Humans ,Prospective Studies ,Lung cancer ,education ,lcsh:Science ,Aged ,Aged, 80 and over ,B-Lymphocytes ,education.field_of_study ,Multidisciplinary ,business.industry ,Myeloid-Derived Suppressor Cells ,lcsh:R ,Immunotherapy ,Middle Aged ,medicine.disease ,Progression-Free Survival ,Immune checkpoint ,Killer Cells, Natural ,Nivolumab ,medicine.anatomical_structure ,Cancer research ,Myeloid-derived Suppressor Cell ,Tumour immunology ,Biomarker (medicine) ,Female ,lcsh:Q ,business - Abstract
Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we sought to identify a more accurate predictive blood biomarker for evaluating anti-PD-1 response. We evaluated the frequencies of T cells, B cells, natural killer (NK) cells, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), mononuclear myeloid-derived suppressor cells (M-MDSCs), and Lox-1+ PMN-MDSCs in peripheral blood samples of 62 NSCLC patients before and after nivolumab treatment. Correlation of immune-cell population frequencies with treatment response, progression-free survival, and overall survival was also determined. After the first treatment, the median NK cell percentage was significantly higher in responders than in non-responders, while the median Lox-1+ PMN-MDSC percentage showed the opposite trend. NK cell frequencies significantly increased in responders but not in non-responders. NK cell frequency inversely correlated with that of Lox-1+ PMN-MDSCs after the first treatment cycle. The NK cell-to-Lox-1+ PMN-MDSC ratio (NMR) was significantly higher in responders than in non-responders. Patients with NMRs ≥ 5.75 after the first cycle had significantly higher objective response rates and longer progression-free and overall survival than those with NMRs
- Published
- 2020