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Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expression is used to predict anti-PD-1 therapy responses in NSCLC, its accuracy is relatively less. Therefore, we sought to identify a more accurate predictive blood biomarker for evaluating anti-PD-1 response. We evaluated the frequencies of T cells, B cells, natural killer (NK) cells, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), mononuclear myeloid-derived suppressor cells (M-MDSCs), and Lox-1+ PMN-MDSCs in peripheral blood samples of 62 NSCLC patients before and after nivolumab treatment. Correlation of immune-cell population frequencies with treatment response, progression-free survival, and overall survival was also determined. After the first treatment, the median NK cell percentage was significantly higher in responders than in non-responders, while the median Lox-1+ PMN-MDSC percentage showed the opposite trend. NK cell frequencies significantly increased in responders but not in non-responders. NK cell frequency inversely correlated with that of Lox-1+ PMN-MDSCs after the first treatment cycle. The NK cell-to-Lox-1+ PMN-MDSC ratio (NMR) was significantly higher in responders than in non-responders. Patients with NMRs ≥ 5.75 after the first cycle had significantly higher objective response rates and longer progression-free and overall survival than those with NMRs
- Subjects :
- Adult
Male
Lung Neoplasms
T-Lymphocytes
medicine.medical_treatment
Programmed Cell Death 1 Receptor
Cell
Population
lcsh:Medicine
Article
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Prospective Studies
Lung cancer
education
lcsh:Science
Aged
Aged, 80 and over
B-Lymphocytes
education.field_of_study
Multidisciplinary
business.industry
Myeloid-Derived Suppressor Cells
lcsh:R
Immunotherapy
Middle Aged
medicine.disease
Progression-Free Survival
Immune checkpoint
Killer Cells, Natural
Nivolumab
medicine.anatomical_structure
Cancer research
Myeloid-derived Suppressor Cell
Tumour immunology
Biomarker (medicine)
Female
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....9233cc96c12fc4bd59256cd620b91f54