437 results on '"Chromane"'
Search Results
2. A Practical Electrochemical Approach for Synthesizing Selenyl-Dihydrobenzofurans and Chromane with a Tetrasubstituted Carbon Center.
- Author
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Chen, Qisheng, Xiang, Kai, Chen, Yiyi, Kong, Xianqiang, Chen, Xiaohui, and Cao, Zhong-Yan
- Subjects
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AIR conditioning , *CARBON , *PHENOL - Abstract
A straightforward and efficient electrochemical method for the anodic oxidative selenenylation of 2-(2-arylallyl)phenols and a 2-(3-arylbut-3-en-1-yl)phenol with diselenides under ambient air conditions has been outlined. This method allows for the synthesis of selenyl-dihydrobenzofurans and a chromane featuring a sterically hindered tetrasubstituted carbon center, demonstrated through 25 examples with yields reaching up to 98%. Initial mechanistic investigations suggest the likely participation of pivotal seleniranium cation species in regulating the reactivity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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3. Visible-Light-Induced Oxidative Generation of o -Quinone Methides for Inverse-Electron-Demand [4+2] Cycloaddition Reactions.
- Author
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Nohara, Shoya, Iwai, Suguru, Yamaguchi, Naoya, Asada, Yosuke, Kamiyama, Yusuke, Tanaka, Yuta, Tanaka, Kenta, and Hoshino, Yujiro
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RING formation (Chemistry) , *ORGANIC synthesis , *QUINONE - Abstract
This article discusses the visible-light-induced oxidative generation of o-quinone methides (o-QMs) for inverse-electron-demand [4+2] cycloaddition reactions. The authors explore different methods for generating o-QMs and highlight the potential of visible-light-induced generation to overcome issues associated with high-energy irradiation. They present their findings on the reaction of 2-(sulfanylmethyl)phenol with styrene using a thioxanthylium photoredox catalyst under green light irradiation, resulting in the formation of chromanes with high regioselectivity and good yields. The authors believe that this method provides a promising tool for the oxidative generation of o-QMs and has important applications in synthetic organic chemistry. [Extracted from the article]
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- 2023
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4. Photocatalytic Ketyl Radical Initiated Cketyl−Csp2/Csp3 Coupling on ZnIn2S4.
- Author
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Han, Chuang, Han, Guanqun, Habibur Rahman, Md, Mannodi‐Kanakkithodi, Arun, and Sun, Yujie
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RADICALS (Chemistry) , *COUPLING reactions (Chemistry) , *ADENOSYLMETHIONINE , *VISIBLE spectra , *CARBON-carbon bonds , *PHOTOCATALYSTS - Abstract
Visible‐light‐driven C−C bond formation utilizing ketyl radical (Cketyl) species has attracted increasing attention recently, as it provides a direct route for the synthesis of complex molecules. However, the most‐developed homogeneous photocatalytic systems for the generation and utilization of ketyl radicals usually entail noble metal‐based (e. g. Ru and Ir) photosensitizers, which suffer from not only high cost but also potential degradation and hence pose challenges in product separation and purification. In contrast, readily accessible, inexpensive, and recyclable semiconductors represent a class of attractive and alternative photocatalysts but remain much less explored for photocatalytic ketyl radical initiated C−C bond formation. This work demonstrates that a wide range of industrially important chemicals, including substituted chromanes and tertiary alcohols, can be produced on ZnIn2S4 under visible light irradiation through intramolecular cyclization (Cketyl−Csp2) and intermolecular cross‐coupling (Cketyl−Csp3) reactions, respectively, using ketyl radicals. A suite of experimental studies aided by computational investigation were carried out to shed light on the mechanistic insights of these two types of ketyl radical initiated C−C coupling reactions on ZnIn2S4. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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5. Photocatalytic Ketyl Radical Initiated Cketyl−Csp2/Csp3 Coupling on ZnIn2S4.
- Author
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Han, Chuang, Han, Guanqun, Habibur Rahman, Md, Mannodi‐Kanakkithodi, Arun, and Sun, Yujie
- Subjects
RADICALS (Chemistry) ,COUPLING reactions (Chemistry) ,ADENOSYLMETHIONINE ,VISIBLE spectra ,CARBON-carbon bonds ,PHOTOCATALYSTS - Abstract
Visible‐light‐driven C−C bond formation utilizing ketyl radical (Cketyl) species has attracted increasing attention recently, as it provides a direct route for the synthesis of complex molecules. However, the most‐developed homogeneous photocatalytic systems for the generation and utilization of ketyl radicals usually entail noble metal‐based (e. g. Ru and Ir) photosensitizers, which suffer from not only high cost but also potential degradation and hence pose challenges in product separation and purification. In contrast, readily accessible, inexpensive, and recyclable semiconductors represent a class of attractive and alternative photocatalysts but remain much less explored for photocatalytic ketyl radical initiated C−C bond formation. This work demonstrates that a wide range of industrially important chemicals, including substituted chromanes and tertiary alcohols, can be produced on ZnIn2S4 under visible light irradiation through intramolecular cyclization (Cketyl−Csp2) and intermolecular cross‐coupling (Cketyl−Csp3) reactions, respectively, using ketyl radicals. A suite of experimental studies aided by computational investigation were carried out to shed light on the mechanistic insights of these two types of ketyl radical initiated C−C coupling reactions on ZnIn2S4. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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6. A Computational Study on the Radical Cascade Cyclization Mechanism of Synthesis of Benzo[b]oxepinones and Chromanes.
- Author
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Fıstıkçı, Meryem
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RADICALS (Chemistry) , *RING formation (Chemistry) , *PRODUCT elimination , *DENSITY functional theory - Abstract
A computational study on the reaction mechanism of the effective synthesis of sulfonated benzo[b]oxepinones and chromanes by radical cascade cyclization is carried out employing the density functional theory (DFT). Based on our computations, the rate‐determining step is the formation of arylsulfonyl radical for the reaction scheme. Our calculations show that the reaction of 1,8‐ and 1,7‐enynes with arylsulfonyl radical proceeds by forming more thermodynamically stable intermediates. Therefore, 1,8‐enynes prefer 7‐exo‐trig cyclization, while 1,7‐enynes prefer 6‐exo‐trig cyclization. Our computations are consistent with experimental results of the radical cascade cyclization of 1,8‐ and 1,7‐enynes. Moreover, our computations show that if the reaction is carried out in a proton‐free solvent, the elimination product can be obtained from the cascade radical cyclization of the 1,7‐enyne. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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7. In vitro and in vivo Antidiabetic Evaluation of Synthesised Novel New Chromane and its Derivatives.
- Author
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Kamboj, Sonia, Chaudhary, Jasmine, Jain, Akash, and Singh, Randhir
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HYPOGLYCEMIC agents , *CHEMICAL synthesis , *IN vivo studies , *META-synthesis , *METFORMIN , *ACARBOSE - Abstract
Background: To evaluate biological activity of synthesised new chromane and its analogues. Materials and Methods: New chromane {3,5,7-trihydroxy 2-(4-hydroxy benzyl) chroman-4-one} isolated from dried leaves of Dillenia indica Linn., family Dilleniaceae is structurally relating with various reported chroman-4-one derivatives displaying remarkable in vivo antidiabetic activity. But the literature reveals that 0.8 - 1.0% yield of pure new chromane was obtained in isolation. Following reported literature data of synthesis and in silico study; Synthesized new chromane and its derivatives (S23-S32) were investigated for in vitro (a-amylase and a-glucosidase) as well as in vivo antidiabetic evaluation respectively. Result and Conclusion: in vitro hypoglycaemic study also displayed the significant antidiabetic potential of new chromane and its O-alkyl substituents (especially S23) while other synthesized compounds (S27-S32) reported for moderate to mild effects w.r. t. reference drug (acarbose). Moreover, synthetic new chromane and O-alkyl substituent (S23) exhibited maximum antidiabetic activity also in terms of lowering glucose concentration while others (S27-S32) showed mild anti-diabetic effect in comparison to reference drug (metformin). [ABSTRACT FROM AUTHOR]
- Published
- 2023
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8. Three new chromanes and one new flavone C-glycoside from Mallotus apelta.
- Author
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Anh, Nguyen Hoang, Yen, Duong Thi Hai, Cuong, Nguyen The, Tai, Bui Huu, Yen, Pham Hai, Chinh, Pham The, Cuong, Pham Van, Nam, Nguyen Hoai, Kiem, Phan Van, Cho, Su-Hyeon, Park, SeonJu, and Nhiem, Nguyen Xuan
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FOLIAR diagnosis , *HIGH performance liquid chromatography , *HEALTH outcome assessment , *PHYTOCHEMICALS , *PLANTS , *CELL survival , *FLAVONES , *DESCRIPTIVE statistics , *RESEARCH funding , *PLANT extracts , *MOLECULAR structure , *CELL surface antigens , *CELL lines , *SPECTRUM analysis , *IMMUNODIAGNOSIS , *PROSTATE tumors , *BREAST tumors - Abstract
Three new chromanes, malloapeltas J–L (1–3), and one new flavone C-glycoside, malloflavoside (4), together with four known compounds, apigenin 6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranoside (5), apigenin 6-C-β-D-glucopyranosyl-8-C-α-L-arabinopyranoside (6), apigenin 7-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (7), and acantrifoside E (8) were isolated from the methanol extract of the leaves of Mallotus apelta. Their chemical structures were determined using spectroscopic methods, including 1D, 2D NMR, and HR-ESI-MS methods. All the isolated compounds were evaluated their cytotoxic activity against human prostate cancer (PC-3) and human breast cancer (MCF-7) cells, but none of them showed cytotoxicities on both human cancer cell lines. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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9. Apparent 6‐endo‐trig Carbofluorination of Alkenes Enabled by Palladium‐Based Dyotropic Rearrangement.
- Author
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Gong, Jing, Wang, Qian, and Zhu, Jieping
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BORONIC acid derivatives , *ALKENES , *ORGANIC synthesis , *RING formation (Chemistry) - Abstract
Alkene difunctionalization featuring an intramolecular carbometallation step has been developed into a powerful transformation in organic synthesis. The 5‐exo‐trig carbometallation is in general highly favored over the alternative 6‐endo‐trig cyclization. We report herein a formal 6‐endo‐trig carbofluorination protocol by combining the conventional 5‐exo‐trig carbopalladation with a chemoselective 1,2‐aryl/Pd dyotropic rearrangement. Treatment of 2‐(2‐alkylallyloxy)phenyl boronic acid derivatives in the presence of a catalytic amount of Pd(dba)2, 4,4′‐di‐tert‐butyl‐2,2′‐bipyridine and Selectfluor affords chromanes with concurrent generation of a tertiary alkyl fluoride function. A σ‐alkyl‐PdII species resulting from the 5‐exo‐trig carbopalladation process is isolated and characterized by X‐ray crystallographic analysis. Its oxidation to PdIV complex triggers the chemoselective dyotropic rearrangement leading to the ring expansion product. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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10. (E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione.
- Author
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Rahmani, Fatlinda, Crochet, Aurélien, and Zobi, Fabio
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CHEMICAL structure , *X-ray diffraction , *SPECTROMETRY , *DIAZOTIZATION - Abstract
(E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione was synthesized for the first time and the compound was characterized by 1H and 13C spectroscopy, IR spectroscopy, and UV-Vis. The chemical structure and isomeric configuration of the molecule were confirmed by single-crystal X-ray diffraction. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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11. (E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione
- Author
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Fatlinda Rahmani, Aurélien Crochet, and Fabio Zobi
- Subjects
4-hydroxycoumarin ,2-amino-4-methyl thiazole ,diazotization ,hydrazineylidene ,chromane ,Inorganic chemistry ,QD146-197 - Abstract
(E)-3-(2-(4-methylthiazol-2-yl)hydrazineylidene)chromane-2,4-dione was synthesized for the first time and the compound was characterized by 1H and 13C spectroscopy, IR spectroscopy, and UV-Vis. The chemical structure and isomeric configuration of the molecule were confirmed by single-crystal X-ray diffraction.
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- 2022
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12. New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line.
- Author
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Yurttaş, Leyla, Temel, Halide Edip, Aksoy, Mehmet Onur, Bülbül, Emre Fatih, and Çiftçi, Gülşen Akalin
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THIAZOLES , *CANCER cells , *CELL lines , *THIAZOLE derivatives , *LUNG cancer , *ANTINEOPLASTIC agents - Abstract
Novel 2‐[2‐(chroman‐4‐ylidene)hydrazinyl]‐4/5‐substituted thiazole derivatives (2a–i) were synthesized and investigated for their anticancer activity. Cytotoxic activity on A549 and NIH/3T3 cell lines was determined, most of the compounds exhibited high cytotoxic profile with selectivity. Selected compounds 2b, 2c, 2e, 2g, 2h, and 2i were tested to determine induction of apoptosis, mitochondrial membrane depolarization, and cell cycle arrest. The results showed that the compounds induced apoptosis intrinsically that they triggered loss of mitochondrial potential through increasing the accumulation of cells in G2/M. Besides, intrinsic apoptotic pathway was supported by down‐regulation of anti‐apoptotic protein Bcl‐2 and up‐regulation of proapoptotic protein Bax. Molecular docking study for compounds 2b, 2c, and 2g was promoted experimental outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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13. Umpolung Strategy for Arene C−H Etherification Leading to Functionalized Chromanes Enabled by I(III) N‐Ligated Hypervalent Iodine Reagents.
- Author
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Mikhael, Myriam, Guo, Wentao, Tantillo, Dean J., and Wengryniuk, Sarah E.
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ETHERIFICATION , *UMPOLUNG , *DERIVATIZATION , *RING formation (Chemistry) , *ALCOHOL - Abstract
The direct formation of aryl C−O bonds via the intramolecular dehydrogenative coupling of a C−H bond and a pendant alcohol represents a powerful synthetic transformation. Herein, we report a method for intramolecular arene C−H etherification via an umpoled alcohol cyclization mediated by an I(III) N‐HVI reagent. This approach provides access to functionalized chromane scaffolds from primary, secondary and tertiary alcohols via a cascade cyclization‐iodonium salt formation, the latter providing a versatile functional handle for downstream derivatization. Computational studies support initial formation of an umpoled O‐intermediate via I(III) ligand exchange, followed by competitive direct and spirocyclization/1,2‐shift pathways. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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14. N -Selenocyanato-Dibenzenesulfonimide: A New Electrophilic Selenocyanation Reagent.
- Author
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Zhu, Deng, Ye, Ai-Hui, and Chen, Zhi-Min
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ELECTROPHILES , *LEWIS acids , *NUCLEOPHILES , *ORGANOSELENIUM compounds , *ALKENES - Abstract
A new electrophilic selenocyanation reagent N -seleno-cyanato-dibenzenesulfonimide was readily prepared in two steps from commercially available dibenzenesulfonimide for the first time. A variety of electrophilic selenocyanato reactions of nucleophiles have been achieved using it as selenocyanato source under mild and simple conditions. Numerous SeCN-containing compounds were obtained in moderate to excellent yields. Meanwhile, a Lewis acid mediated tandem selenocyanation/cyclization reaction of alkenes with phenols, which provided simple methods for the formation of various SeCN-containing chromanes and dihydrobenzofurans in moderate to good yields, has also been developed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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15. COUMARIN: A VALID SCAFFOLD IN MEDICINAL CHEMISTRY.
- Author
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Surana, Khemchand R., Mahajan, Sunil K., and Patil, Shital J.
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PHARMACEUTICAL chemistry , *COUMARINS , *PHOTOSYNTHESIS - Abstract
The coumarin scaffold is an important structure in medicinal chemistry because it is found in several naturally occurring molecules which exhibit a variety of biological activities, such as anti-cancer, anti-inflammatory, anti-diabetic, antimicrobial, and antiviral, antifungal. In addition, various synthetic coumarins motifs are present in marketed drugs. They are also involved in the actions of the photosynthesis, control of respiration, plant growth hormones and growth regulators, and also defense against infection. This review will provide an overview of coumarin moieties with medicinal aspects synthesized in the last 15 years and will cover the most potent molecule in each report. In this review, different synthesis methods of coumarin and their derivatives have been covered. [ABSTRACT FROM AUTHOR]
- Published
- 2021
16. Crystal structure and Hirshfeld surface analysis of rac-2-[2-(4-chlorophenyl)-3,4-dihydro-2H-1-benzopyran-4-ylidene]hydrazine-1-carbothioamide
- Author
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Ruokuosenuo Zatsu, Prabhakar Maddela, M. Indira Devi, Ranjit Singh, and Chullikkattil P. Pradeep
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crystal structure ,flavanone ,chromane ,thiosemicarbazide ,Schiff base ,N—H...S hydrogen bonds ,supramolecular chemistry ,Hirshfeld surface analysis ,Crystallography ,QD901-999 - Abstract
In the title compound, C16H14N3OSCl, a Schiff base derivative of a thiosemicarbazide with a flavanone, the 4-chlorophenyl ring is inclined to the benzene ring of the chromane ring system by 30.72 (12)°. The pyran ring has an envelope conformation with the methine C atom as the flap. The mean plane of the thiourea unit is twisted with respect to the benzene ring of the chromanone ring system, subtending a dihedral angle of 19.78 (19)°. In the crystal, molecules are linked by two pairs of N—H...S hydrogen bonds, forming inversion dimers enclosing R22(8) ring motifs, which are linked to form ribbons propagating along the b-axis direction. The intermolecular contacts in the crystal have been analysed using Hirshfeld surface analysis.
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- 2019
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17. Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction
- Author
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Razieh Navari, Saeed Balalaie, Saber Mehrparvar, Fatemeh Darvish, Frank Rominger, Fatima Hamdan, and Sattar Mirzaie
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chromane ,domino reaction ,fused heterocyclic skeletons ,pyrazolopyridines ,Science ,Organic chemistry ,QD241-441 - Abstract
An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.
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- 2019
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18. Bifunctional Guanidines as Hydrogen-Bond-Donating Catalysts
- Author
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Kobayashi, Yusuke, Takemoto, Yoshiji, Maes, Bert, Series editor, Cossy, Janine, Series editor, Polanc, Slovenko, Series editor, and Selig, Philipp, editor
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- 2017
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19. Gold Catalysis of Non-Conjugated Haloacetylenes.
- Author
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Siera, Hannah, Semleit, Nina, Kreuzahler, Mathis, Wölper, Christoph, and Haberhauer, Gebhard
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CATALYSIS , *RING formation (Chemistry) , *DIMERIZATION , *GOLD , *INDENE , *HALOGENS , *PALLADIUM , *GOLD catalysts - Abstract
Gold-catalyzed reactions of conjugated haloacetylenes are well known and usually result in the formation of addition or dimerization products. Herein, we report a gold-catalyzed reaction of non-conjugated- haloacetylenes, which leads exclusively to the halogenated cyclization products. Remarkable is the gold-catalyzed reaction of tritylhaloacetylenes to haloindene derivatives, as mechanistic studies reveal that an 1,2-aryl shift occurs in the initially formed gold complex. The potential functionalization at the halogen atom and the wide scope of these cyclization reactions make them an attractive method for the construction of cyclic systems. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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20. Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation
- Author
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Oldokh Otgon, Suvd Nadmid, Christian Paetz, Hans-Martin Dahse, Kerstin Voigt, Stefan Bartram, Wilhelm Boland, and Enkhmaa Dagvadorj
- Subjects
Iris tenuifolia ,Iridaceae ,chromane ,macrolide ,flavonoids ,antimicrobial ,Organic chemistry ,QD241-441 - Abstract
Phytochemical investigation of the ethanol extract of underground parts of Iris tenuifolia Pall. afforded five new compounds; an unusual macrolide termed moniristenulide (1), 5-methoxy-6,7-methylenedioxy-4-O-2′-cycloflavan (2), 5,7,2′,3′-tetrahydroxyflavanone (3), 5-hydroxy-6,7-dimethoxyisoflavone-2′-O-β-d-glucopyranoside (9), 5,2′,3′-dihydroxy-6,7-dimethoxyisoflavone (10), along with seven known compounds (4–8, 11–12). The structures of all purified compounds were established by analysis of 1D and 2D NMR spectroscopy and HR-ESI-MS. The antimicrobial activity of the compounds 1–3, 5, 9, and 10 was investigated using the agar diffusion method against fungi, Gram-positive and Gram-negative bacteria. In consequence, new compound 3 was found to possess the highest antibacterial activity against Enterococcus faecalis VRE and Mycobacterium vaccae. Cell proliferation and cytotoxicity tests were also applied on all isolated compounds and plant crude extract in vitro with the result of potent inhibitory effect against leukemia cells. In particular, the newly discovered isoflavone 10 was active against both of the leukemia cells K-562 and THP-1 while 4–6 of the flavanone type compounds were active against only THP-1.
- Published
- 2021
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21. Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones
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Luis A. González, Sara Robledo, Yulieth Upegui, Gustavo Escobar, and Wiston Quiñones
- Subjects
Trypanosoma cruzi ,chromane ,phenolic compounds ,prenyl derivatives ,Organic chemistry ,QD241-441 - Abstract
American trypanosomiasis (Chagas disease) caused by the Trypanosoma cruzi parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the migration of populations from South and Central America. At present, there is no vaccine available and chemotherapeutic options are reduced to nifurtimox and benznidazole. Therefore, the discovery of new molecules is urgently needed to initiate the drug development process. Some acetophenones and chalcones, as well as chromane-type substances, such as chromones and flavones, are natural products that have been studied as trypanocides, but the relationships between structure and activity are not yet fully understood. In this work, 26 compounds were synthesized to determine the effect of hydroxyl and isoprenyl substituents on trypanocide activity. One of the compounds showed interesting activity against a resistant strain of T. cruzi, with a half effective concentration of 18.3 µM ± 1.1 and an index of selectivity > 10.9.
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- 2021
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22. Enantioselektive Synthese von 3‐Fluorchromanen durch Iod(I)/Iod(III)‐Katalyse.
- Author
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Sarie, Jérôme C., Thiehoff, Christian, Neufeld, Jessica, Daniliuc, Constantin G., and Gilmour, Ryan
- Abstract
Das Chromangerüst findet sich in einer Vielzahl von kleinen, bioaktiven Molekülen, in denen die 3‐Position häufig oxidiert wird. Motiviert durch die Wichtigkeit dieser Position für die Wirksamkeit sowie die Bedeutung der Bioisosterie in der Wirkstoffforschung wurde eine Iod(I)/Iod(III)‐Katalysestrategie für den Zugang zu enantiomerenangereicherten 3‐Fluorchromanen entwickelt (bis zu 7:93 e.r.). Die In‐situ‐Erzeugung von ArIF2 ermöglicht die direkte Fluorzyklisierung von Allylphenylethern, um neue Molekülgerüste zu erzeugen, die den stereoelektronischen gauche‐Effekt zeigen. Mechanistische Untersuchungen unter Verwendung von deuterierten Substraten bestätigen einen stereospezifischen Prozess, der mit einem Reaktionsverlauf des Typs IIinv übereinstimmt. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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23. Asymmetric Synthesis of Chiral Chromanes by Copper‐Catalyzed Hydroamination of 2H‐Chromenes.
- Author
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Yang, Qingjing, Li, Sifeng, and Wang, Jun (Joelle)
- Subjects
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HYDROAMINATION , *ASYMMETRIC synthesis , *ESTERS - Abstract
A copper/(R)‐DTBM‐SEGPHOS‐catalyzed enantioselective hydroamination of 2H‐chromenes employing hydrosilanes and hydroxylamine esters has been developed. This protocol offers a highly efficient and direct route for accessing a series of 4‐aminochromanes in 50–88 % yields with 59–99 % enantioselectivities under mild reaction conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
24. Synthesis of novel 3-[(2R*)-2-[(2S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]-urea/thiourea derivatives and evaluation of their antimicrobial activities.
- Author
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Mannam, Madhava Rao, S., Srimurugan, Kumar, Pramod, Chamarthi, Naga Raju, and K. R. S., Prasad
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THIOUREA , *UREA derivatives , *LEAD compounds , *ETHANOL , *EVALUATION - Abstract
A new series of biologically active 3-[(2R*)-2-[(2S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]-urea/thiourea derivatives (1) have been designed and synthesized in four steps from 6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene (2). The structures of newly synthesized compounds (1a–j) were confirmed by 1H, 13C NMR, and HRMS. The major advantages of the present article include the development of an efficient eluent system for good separation of diastereomers (2a and 2b) with high yields and synthesis of (R*)-2-(benzylamino)-1-((S*)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol (3) in high yields (87%) from epoxide (2a) through new reaction conditions. The synthesized compounds (1a–j) exhibited moderate to excellent antimicrobial activities against both bacterial strains (gram + Ve and gram –Ve strains) and fungal strains. Among the tested compounds, promising lead compounds were identified (compounds 1a and 1d against bacterial strains and compound 1h and 1j against fungal strains) and their antimicrobial activities are comparable with the reference standard. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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25. Condensation reactions of dialkoxy-2-phenylchroman-4-ones with 1,2-diamines: A method for the preparation of chromenoquinoxalines.
- Author
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Watkins, Hannah, Lee, Gerald, Ouedraogo, Pangbewindin H.B., Padgett, Clifford W., Nguyen, Khoa, Artis, Rylan, and Quillian, Brandon P.
- Subjects
- *
DIAMINES , *NUCLEAR magnetic resonance spectroscopy , *RACEMIC mixtures , *MELTING points , *PHENYLENEDIAMINES , *HEMIACETALS - Abstract
[Display omitted] Reactions of dialkoxy-2-phenylchroman-4-ones (2,3-diethoxy-3-hydroxy-2-phenylchroman-4-one (1) and 2,3-dimethoxy-3-hydroxy-2-phenylchroman-4-one (2)) with various phenylenediamines in refluxing chloroform led to quinoxaline ring formation to produce racemic mixtures of chromenoquinoxaline molecules in good to moderate yields (3 – 10). The proposed mechanism involves the hemiacetals (1 and 2) rearranging upon heating to form a reactive dione intermediate that subsequently reacts with phenylenediamine derivatives to produce the title compounds. Reactions of 1 and 2 with asymmetric phenylenediamines led to mixtures of two regioisomers, for which the major products were dictated by the relative reactivity of the nucleophilic amine and the electrophilic carbonyl groups. The chromenoquinoxaline products were characterized by 1H, 13C, 19F (when necessary), nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, melting point determination, and in some cases (compounds 6 – 10) single crystal X-ray diffraction studies. Herein, the synthesis, characterization, and reactivity of this new class of molecules are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
26. Water-Tolerant Trifloaluminate Ionic Liquids: New and Unique Lewis Acidic Catalysts for the Synthesis of Chromane
- Author
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Piotr Latos, Alice Culkin, Natalia Barteczko, Sławomir Boncel, Sebastian Jurczyk, Lucy C. Brown, Peter Nockemann, Anna Chrobok, and Małgorzata Swadźba-Kwaśny
- Subjects
trifloaluminate ionic liquids ,metal triflates ,chromane ,carbon nanotubes ,SILP ,Chemistry ,QD1-999 - Abstract
The first example of triflometallate ionic liquids, named in analogy to chlorometallate ionic liquids, is reported. Trifloaluminate ionic liquids, synthesized from 1-alkyl-3-methylimidazolium triflates and aluminum triflate, were characterized by multinuclear NMR spectroscopy and FT-IR spectroscopy, revealing the existence of oligonuclear, multiply-charged trifloaluminate anions, with multiple bridging triflate modes. Acceptor numbers were determined to quantify their Lewis acidity, rendering trifloaluminate ionic liquids as medium-strength Lewis acids (AN = ca. 65). Used as acidic catalysts in the cycloaddition of 2,4-dimethylphenol and isoprene (molar ratio 2:1) to prepare chromane, trifloaluminate systems outperformed literature systems, showing high activity (conversions 94–99%, selectivities 80–89%) and at low loadings (0.2 mol%) at 35°C. Using these new systems as supported ionic liquid phase (SILP) on multi-walled carbon nanotubes (ionic liquid loading 16 wt%) delivered a recyclable catalytic system, with activity enhanced with respect to the homogenous regime.
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- 2018
- Full Text
- View/download PDF
27. Nickel(II)‐Catalyzed Diastereo‐ and Enantioselective Michael/ Hemiacetalization Cascade Reaction of α‐Ketoesters with 2‐(2‐Nitrovinyl)phenols.
- Author
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Chen, Long, Yang, Wu‐Lin, Shen, Jia‐Huan, and Deng, Wei‐Ping
- Subjects
- *
NICKEL , *PHENOLS , *DERIVATIZATION , *STEREOSELECTIVE reactions , *CATALYSTS - Abstract
A nickel(II)/diamine‐catalyzed diastereo‐ and enantioselective Michael/hemiacetalization cascade reaction of α‐ketoesters with 2‐(2‐nitrovinyl)phenols has been established, thus providing a range of structurally diverse polysubstituted chromanes in good yields and excellent stereoselectivities (up to 89% yield, >20:1 dr, >99% ee). Moreover, the gram‐scale experiment was performed with only 0.5 mol% of catalyst, and tricyclic furanobenzodihydropyran compound was gained by the derivatization of product, which showed the great synthetic potential of this strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
28. Synthesis, characterization and crystallographic analysis of N-2-(tert-butylcarbomyl) (4-chlorophenyl methyl)-6-fluoro-N- (3, 4, 5-triethoxyphenyl) chroman-2-carboxamide.
- Author
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Kapadiya, Khushal, Dhaduk, Bhavin, and Khunt, Ranjan C.
- Subjects
- *
TRICLINIC crystal system , *DIHEDRAL angles , *CRYSTAL structure , *UNIT cell , *SPACE groups - Abstract
The title compound (UGCl 001) has been prepared by the multicomponent reaction of chromanes (U-4CC) without using catalyst. The compound has been characterized by ¹H and 13C NMR, IR and MS techniques. X-ray crystallographic technique has been applied and the results show that the crystal belongs to the triclinic system having space group P-1(#2) with unit cell parameters, a = 10.704(2) Å, b = 12.843(2) Å, c = 13.179(2) Å, α = 116.968(4)°, β = 103.203(4)°, γ = 95.788(5)°, V = 1527.8(4) ųand Z = 2. In the title compound, dihedral angles between the planes of the chromane ring (A), substituted aniline ring (B), substituted benzaldehyde (C) and tert-butyl isocynides (D) are 121.2 (3), 123.0(2) and 113.0(3) respectively. Intermolecular N--O, C--Cl and C--F interaction has been found in the crystal structure and results in a three dimensional network structure. [ABSTRACT FROM AUTHOR]
- Published
- 2019
29. Crystal structure and Hirshfeld surface analysis of rac-2-[2-(4-chlorophenyl)-3,4-dihydro-2H-1-benzopyran-4-ylidene]hydrazine-1-carbothioamide.
- Author
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Zatsu, Ruokuosenuo, Maddela, Prabhakar, Devi, M. Indira, Singh, Ranjit, and Pradeep, Chullikkattil P.
- Subjects
- *
SURFACE analysis , *CRYSTAL structure , *BENZENE derivatives , *SCHIFF base derivatives , *SURFACE structure , *DIHEDRAL angles - Abstract
In the title compound, C16H14N3OSCl, a Schiff base derivative of a thiosemicarbazide with a flavanone, the 4-chlorophenyl ring is inclined to the benzene ring of the chromane ring system by 30.72 (12)°. The pyran ring has an envelope conformation with the methine C atom as the flap. The mean plane of the thiourea unit is twisted with respect to the benzene ring of the chromanone ring system, subtending a dihedral angle of 19.78 (19)°. In the crystal, molecules are linked by two pairs of N--H···S hydrogen bonds, forming inversion dimers enclosing R2²(8) ring motifs, which are linked to form ribbons propagating along the b-axis direction. The intermolecular contacts in the crystal have been analysed using Hirshfeld surface analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
30. Diastereoselective synthesis of spiro[chromane-3,3′-indolines] and spiro[chromane-3,2′-indenes] via DBU promoted formal [4 + 2]cycloaddition reaction
- Author
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Daqian Wang, Chao-Guo Yan, and Jing Sun
- Subjects
Reaction conditions ,chemistry.chemical_compound ,chemistry ,Functional group ,Chromane ,Medicinal chemistry ,Cycloaddition - Abstract
A new DBU-catalyzed formal [4 + 2] cycloaddition between ortho-hydroxyphenyl-substituted para-quinone methides and electron-deficient dienophiles including 3-methyleneoxindoles and 2-aryldeneindene-1,3-diones was established. A wide range of functionalized spiro[chromane-3,3′-indolines] and spiro[chromane-3,2′-indenes] were successfully synthesized in good yields and with high diastereoselectivity. The features of the reaction included readily available substrates, mild reaction conditions, convenient methodology and good functional group tolerance.
- Published
- 2022
31. Palladium‐Catalyzed Enantioselective Addition of Chiral Metal Enolates to In Situ Generated ortho‐Quinone Methides.
- Author
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Göricke, Fabian and Schneider, Christoph
- Subjects
- *
PALLADIUM catalysts , *ENANTIOSELECTIVE catalysis , *ENOLATES , *QUINONE methides , *STEREOSELECTIVE reactions , *NUCLEOPHILES - Abstract
We describe herein a conceptually novel, cooperative Brønsted acid/base catalyzed process for the conjugate addition of cyclic β‐keto esters to ortho‐quinone methides both generated in situ. Upon hemiacetalization, densely functionalized chiral chromans with two adjacent quaternary and additionally a tertiary stereogenic center were obtained with very good diastereoselectivity (up to >95:5 d.r.) and typically excellent enantioselectivity (up to >99 % ee). The striking feature and key to success is the dual catalytic activation of both nucleophile and electrophile in two separate cycles with a single chiral catalyst. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
32. Crystal structures of two substituted thiazolidine derivatives
- Author
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Vijayan Viswanathan, Naga Siva Rao, Raghavachary Raghunathan, and Devadasan Velmurugan
- Subjects
crystal structure ,thiazolidine derivative ,ferrocenyl ,acenaphthylene ,chromane ,hydrogen bonding ,C—H...π interactions ,Crystallography ,QD901-999 - Abstract
In the first of the compounds reported herein, namely 6′-ferrocenyl-6a′-nitro-6′,6a′,6b′,7′,9′,11a′-hexahydro-2H-spiro[acenaphthylene-1,11′-chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazol]-2-one, [Fe(C5H5)(C29H21N2O4S)], (I), the thiazolidine ring adopts a twist conformation on the methine N—C atoms. In the second compound, viz. 6′-(4-methoxyphenyl)-6a′-nitro-6′,6a′,6b′,7′,9′,11a′-hexahydro-2H-spiro[acenaphthylene-1,11′-chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazol]-2-one, [Fe(C5H5)(C26H19N2O5S)], (II), the thiazolidine ring adopts an envelope conformation with a methine C atom as the flap. In both compounds, the pyrrolidine ring adopts a twist conformation on the thiazolidine and tetrahydropyran C atoms. The mean planes of the thiazolidine and pyrrolidine rings subtend angles of 67.30 (1) and 62.95 (7)° in (I) and (II), respectively, while the mean plane of the pyrrolidine ring makes dihedral angles of 76.53 (1) and 87.74 (7)° with the acenaphthylene ring system in (I) and (II), respectively. In both compounds, an intramolecular C—H...O hydrogen bond forms an S(7) ring motif. In the crystal of (I), molecules are linked via two different C—H...O hydrogen bonds, forming chains along [001] and [100]. In (II), they are linked through C—H...O hydrogen bonds, forming dimers with an R22(10) ring motif while C—H...π interactions link the molecules in a head-to-tail fashion, forming chains along the a-axis direction.
- Published
- 2016
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33. Antidiabetic effect of new chromane isolated from Dillenia indica L. leaves in streptozotocin induced diabetic rats
- Author
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Navpreet Kaur, Lalit Kishore, and Randhir Singh
- Subjects
Antioxidant activity ,Antidiabetic activity ,Chromane ,Dillenia indica ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The chemical constituents of Dillenia indica were isolated together with evaluation of their antioxidant and antidiabetic activity. Alcoholic extract of D. indica (DAE) was subjected to column chromatography for the isolation of compounds and it yielded a new chromane 3,5,7,-trihydroxy-2-(4-hydroxybenzyl)-chroman-4-one. The structure was determined by 1H, 13C-NMR and ESIMS. DAE (100, 200 and 400 mg/kg) and chromane (5 and 10 mg/kg) were administered to streptozotocin (STZ) (50 mg/kg) induced diabetic rats to assess their effect on fasting blood glucose, serum insulin and lipid levels. Oral administration of chromane and DAE significantly attenuated the elevated fasting blood glucose, lipid levels and oxidative stress. The results indicated that DAE and chromane isolated from D. indica possessed antioxidant and antidiabetic activity and could be a therapeutic agent for regulating several pharmacological targets for management of diabetes.
- Published
- 2016
- Full Text
- View/download PDF
34. Unusual Calixarenes Incorporating Chromene and Benzofuran Moieties Obtained via Propargyl Claisen Rearrangement
- Author
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Paolo Della Sala, Silvano Geremia, Placido Neri, Annunziata Soriente, Mariantonietta D'Acunto, Neal Hickey, Carmine Gaeta, Carmen Talotta, Antonio Rescifina, Margherita De Rosa, Soriente, Annunziata, D’Acunto, Mariantonietta, Talotta, Carmen, Gaeta, Carmine, Della Sala, Paolo, De Rosa, Margherita, Geremia, Silvano, Hickey, Neal, Rescifina, Antonio, and Neri, Placido
- Subjects
Aromatic compounds ,Chemical structure ,Chemical reactions ,Claisen rearrangement ,Propargyls ,Letter ,Aromatic compound ,Diradical ,Allene ,Organic Chemistry ,Sigmatropic reaction ,Biochemistry ,Medicinal chemistry ,chemistry.chemical_compound ,chemistry ,Calixarene ,Propargyl ,Chromane ,Physical and Theoretical Chemistry ,Benzofuran ,Chemical reaction - Abstract
Monopropargyloxy-tripropoxy-calix[4]arene 1 was subjected to a propargyl Claisen rearrangement to give unusual calix[3]arene[1]chromene and homocalix[3]arene[1]benzofuran macrocycles. Quantum mechanical density functional theory calculations indicated that an initial [3,3] sigmatropic reaction affords a highly reactive allene intermediate, stabilized by two main diradical pathways leading to six- and five-membered oxygenated rings. In the presence of a n-butylammonium guest, calix[3]-arene[1]chromane 6 forms two stereoisomeric complexes stabilized by +N−H···O and cation···π interactions.
- Published
- 2021
35. Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane
- Author
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Alastair J. J. Lennox, Darren L. Poole, and Sayad Doobary
- Subjects
chemistry.chemical_classification ,Allylic rearrangement ,Chemistry ,Alkene ,Organic Chemistry ,Hypervalent molecule ,Alkenes ,Combinatorial chemistry ,Redox ,BCS and TECS CDTs ,chemistry.chemical_compound ,Phenols ,Intramolecular force ,Chromane ,Phenol ,Selectivity ,Oxidation-Reduction ,Ethers ,Iodine - Abstract
The 3-substituted chromane core is found in several bioactive natural products. Herein, we describe a route to 3-fluorinated chromanes from allylic phenol ethers. Our external oxidant-free approach takes advantage of an electro-chemical generation of a hypervalent iodine species, difluoro-λ3-tolyl iodane, which mediates the alkene fluoroaryla-tion. High yields and selectivity for this transformation are achieved for electron poor substrates. The redox chemistry has been characterized for the electrochemical generation of the iodane in the presence of fluoride, and insights into the mechanism are given. The transformation has been demonstrated on larger gram scales, which represents the potential broader utility of the process.
- Published
- 2021
36. Crystal structure of 2-oxo-2H-chromen-3-yl 4-chlorobenzoate and Hirshfeld surface analysis
- Author
-
Eric Ziki, Siaka Sosso, Frédérica Mansilla-Koblavi, Abdoulaye Djandé, and Rita Kakou-Yao
- Subjects
crystal structure ,chromane ,hydrogen bond ,π–π interactions ,quantum-chemical calculations ,Hirshfeld surface analysis ,Crystallography ,QD901-999 - Abstract
In the title compound, C16H9ClO4 the dihedral angle between the coumarin ring system [maximum deviation = 0.023 (1) Å] and the benzene ring is 73.95 (8)°. In the crystal, π–π interactions link the dimers into a three-dimensional framework. A quantum chemical calculation is in generally good agreement with the observed structure, although the calculated dihedral angle between the ring systems (85.7%) is somewhat larger than the observed value [73.95 (8)°]. Hirshfeld surface analysis has been used to confirm and quantify the supramolecular interactions.
- Published
- 2017
- Full Text
- View/download PDF
37. Crystal structure of 2-oxo-2H-chromen-3-yl propanoate
- Author
-
Eric Ziki, Jules Yoda, Abdoulaye Djandé, Adama Saba, and Rita Kakou-Yao
- Subjects
crystal structure ,π–π interactions ,C—H...π interactions ,chromane ,quantum-chemical calculations ,Crystallography ,QD901-999 - Abstract
In the title compound, C12H10O4, the dihedral angle between the coumarin ring system [maximum deviation = 0.033 (8) Å] and the propionate side chain is 78.48 (8)°. In the crystal, weak C—H...O hydrogen bonds generate inversion dimers and and C—H...π and π–π interactions link the dimers into a three-dimensional network. A quantum chemical calculation is in good agreement with the observed structure.
- Published
- 2016
- Full Text
- View/download PDF
38. New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on <scp>A549</scp> lung cancer cell line
- Author
-
Mehmet Onur Aksoy, Halide Edip Temel, Emre F. Bülbül, Leyla Yurttaş, and Gülşen Akalın Çiftçi
- Subjects
Lung Neoplasms ,Cell cycle checkpoint ,Molecular Structure ,Antineoplastic Agents ,Apoptosis ,Molecular Docking Simulation ,Structure-Activity Relationship ,Thiazoles ,chemistry.chemical_compound ,chemistry ,Biochemistry ,A549 Cells ,Cell culture ,Drug Discovery ,Humans ,Chromane ,Cytotoxic T cell ,Drug Screening Assays, Antitumor ,Thiazole ,Cytotoxicity ,Selectivity ,Cell Proliferation - Abstract
Novel 2-[2-(chroman-4-ylidene)hydrazinyl]-4/5-substituted thiazole derivatives (2a-i) were synthesized and investigated for their anticancer activity. Cytotoxic activity on A549 and NIH/3T3 cell lines was determined, most of the compounds exhibited high cytotoxic profile with selectivity. Selected compounds 2b, 2c, 2e, 2g, 2h, and 2i were tested to determine induction of apoptosis, mitochondrial membrane depolarization, and cell cycle arrest. The results showed that the compounds induced apoptosis intrinsically that they triggered loss of mitochondrial potential through increasing the accumulation of cells in G2/M. Besides, intrinsic apoptotic pathway was supported by down-regulation of anti-apoptotic protein Bcl-2 and up-regulation of proapoptotic protein Bax. Molecular docking study for compounds 2b, 2c, and 2g was promoted experimental outcomes.
- Published
- 2021
39. Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from Rhododendron capitatum
- Author
-
Kenneth T. Kongstad, Chao Liang, Louise Kjaerulff, Dan Staerk, and Paul R. Hansen
- Subjects
Pharmacology ,Chemistry ,Stereochemistry ,α glucosidase ,Organic Chemistry ,Ethyl acetate ,Pharmaceutical Science ,High resolution ,Analytical Chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,Ursolic acid ,Drug Discovery ,Molecular Medicine ,Chromane ,Hplc pda ,Oleanolic acid ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
Thirteen previously undescribed chromene meroterpenoids, capitachromenic acids A-M (3-6, 7a, 7b, 8a, 8b, 9a, 9b, 10a, 10b, and 11b), were identified from an ethyl acetate extract of Rhododendron capitatum, using dual high-resolution α-glucosidase and PTP1B inhibition profiling in combination with HPLC-PDA-HRMS-SPE-NMR. In addition, one known chromene meroterpenoid, daurichromenic acid (15), and its biosynthetic precursor, grifolic acid (12), two C-methylated flavanones, (2S)-5,7,4'-trihydroxy-8-methylflavanone (1) and farrerol (2), and two triterpenoids, oleanolic acid (14a) and ursolic acid (14b), were identified. New structures were elucidated by extensive 1D and 2D NMR analysis, and absolute configurations of new chromene meroterpenoids were assigned by analysis of their ECD spectra on the basis of the empirical chromane helicity rule and from Rh2(OCOCF3)4-induced ECD spectra by applying the bulkiness rule. Compounds 5, 9a, 9b, 12, and 15 showed α-glucosidase inhibitory activity with IC50 values ranging from 8.0 to 93.5 μM, while compounds 3, 5, 8b, 9a, 9b, 10b, 11b, 12, and 15 showed PTP1B inhibitory activity with IC50 values ranging from 2.5 to 68.1 μM.
- Published
- 2021
40. Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals
- Author
-
Yong-Chao Ming, Xue-Jiao Lv, Yan-Kai Liu, and Ming Liu
- Subjects
chemistry.chemical_compound ,chemistry ,Organic Chemistry ,Enantioselective synthesis ,Iminium ,Chromane ,Physical and Theoretical Chemistry ,Biochemistry ,Combinatorial chemistry ,Cycloaddition - Abstract
An efficient aminocatalytic enantioselective double-activation strategy has been developed that combines several different aminocatalytic modes in a cascade process, such as iminium ion, vinylogous iminium ion, trienamine, and dienamine activations. By using this strategy, 2-hydroxycinnamaldehydes worked well with various dienals via [4 + 2] cycloaddition and the oxa-Michael reaction-initiated cascade, respectively, leading to chiral polycyclic tetrahydrocarbazole and chromane derivatives with excellent diastereo- and enantioselectivities.
- Published
- 2021
41. Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor.
- Author
-
Meyer, Maxime, Foulquier, Sébastien, Dupuis, François, Flament, Stéphane, Grimaud, Linda, Henrion, Daniel, Lartaud, Isabelle, Monard, Gérald, Grillier-Vuissoz, Isabelle, and Boisbrun, Michel
- Subjects
- *
PEROXISOME proliferator-activated receptors , *ANGIOTENSIN II , *LIGANDS (Biochemistry) , *BIOLOGICAL networks , *CHEMICAL synthesis , *DRUG design - Abstract
Abstract Because of the complex biological networks, many pathologic disorders fail to be treated with a molecule directed towards a single target. Thus, combination therapies are often necessary, but they have many drawbacks. An alternative consists in building molecules intended to interact with multiple targets, called designed multiple ligands. We followed such a strategy in order to treat metabolic syndrome, by setting up molecules directed towards both type 1 angiotensin II (AT 1) receptor and peroxisome proliferator-activated receptor-γ (PPAR-γ). For this purpose, many molecules were prepared by merging both pharmacophores following three different strategies. Their ability to activate PPAR-γ and to block AT 1 receptors were evaluated in vitro. This strategy led to the preparation of many new PPAR-γ activating and AT 1 blocking molecules. Among them, some exhibited both activities, highlighting the convenience of this approach. Graphical abstract Image 1 Highlights • New molecules directed towards both AT 1 and PPAR-γ receptor were designed and synthesized. • Their interactions with both receptors were evaluated in vitro and some exhibited dual activity. • Docking experiments revealed their tight interactions with the PPAR-γ receptor. • Preliminary in vivo experiment showed potent antihypertensive activity for one compound. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
42. Green Synthesis and Z/E-Isomerization of Novel Coumarin Enamines Induced by Organic Solvents.
- Author
-
Olyaei, Abolfazl, Javarsineh, Soheila, and Sadeghpour, Mahdieh
- Subjects
- *
ENAMINES , *ORGANIC solvents , *HETEROCYCLIC compounds , *PHENYL compounds , *AMIDES , *PYRAZOLES - Abstract
An efficient and straightforward synthesis of novel (Z/E)-3-[(heteroarylamino)methylidene]chromane-2,4-dione derivatives via a one-pot three-component condensation of 4-hydroxycoumarin, triethyl orthoformate, and heteroaryl amines in the presence of guanidinium chloride as organocatalyst under solvent-free conditions is described. Investigation of spectroscopy data indicated that coumarin enamines exist in the ketoenamine tautomeric form and undergo Z/E-isomerization in respect to the C=C bond in CDCl3 and DMSO-d6 at room temperature. Furthermore, intramolecular hydrogen bonds have been observed in the synthesized compounds. Also, 1H NMR spectra indicated that E-ketoenamines are the major isomers. High to excellent yields, short reaction times, simple workup, and very easy purification of products by non-chromatographic methods are advantages of this synthetic procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
43. Biological activity, structural characterization and crystal packing of chromane-carboxylate derivatives.
- Author
-
Vrábel, Viktor, Sivý, Július, Světlík, Jan, Marchalín, Štefan, and Peter, Šafař
- Subjects
- *
CARBOXYLATE derivatives , *MOLECULAR structure , *CRYSTAL structure , *BENZENE , *HYDROGEN bonding - Abstract
We report here the crystal and molecular structure of a new chromane-derivative, namely isopropyl(2R*,3S*,4S*)-4-(benzo[d]thiazol-2-ylamino)-2-hydroxy-2-ethylchromane-3-carboxylate (I), C21H22N2O4S, which crystallizes as racemate in the space group C2/c. Its structure has been solved using X-ray diffraction data obtained at low temperature (100(2) K). In this compound, the chromane moiety consists of a benzene ring fused with a six-membered heterocyclic ring which adopts a distorted half-chair conformation. The molecules are linked by a combination of O-H . . . N and N-H . . . O hydrogen bonds, resulting in a two-dimensional network which helps stabilizing the crystal structure of the compound (I). Dihedral angle between the chromane and benzothiazol rings is 80.6(1)o. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
44. Computational Structural Revision of a 4-Hydroxy-3-(1′-angeloyloxy-2′,3′-epoxy-3′-methyl)butylacetophenone Compound from Ageratina grandifolia
- Author
-
Armando Navarro-Vázquez
- Subjects
Pharmacology ,Ageratina ,biology ,010405 organic chemistry ,Chemical shift ,Organic Chemistry ,Absolute configuration ,Pharmaceutical Science ,Epoxide ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Computational chemistry ,Drug Discovery ,Proton NMR ,Molecular Medicine ,Chromane ,Molecule ,Derivative (chemistry) - Abstract
The structure of the reported compound 4-hydroxy-3-((S)-1'-angeloyloxy-(R)-2',3'-epoxy-3'-methyl)butylacetophenone (1), isolated from Ageratina grandifolia, has been revised through the use of DFT computational predictions. Re-examination of the reported experimental and DFT computed chemical shifts has led to the proposal of a chromane skeleton rather than the original epoxide derivative. Empirical predictions of the 13C and 1H NMR shifts showed a much better fit for the chromane structure than for the epoxide. The relative configuration of the molecule was established using CASE-3D methodology on the basis of new DFT chemical shielding and J-coupling predictions, allowing the proposal of a new rel-2,2-dimethyl-3R-hydroxy-4S-(1-angeloyloxy)chromane structure (2) for the isolated compound. However, DFT prediction of the optical rotation for the CASE-3D selected configuration/conformations did not provide a conclusive answer for the absolute configuration.
- Published
- 2021
45. Synthesis, Biological Evaluation and Molecular Docking of Novel N-Acyl/Aroyl Spiro[Chromane-2,4′-Piperidin]-4(3H)-One as Potent Anti-Microbial Agents
- Author
-
Mahmoud E. S. Soliman, Mahidansha M. Shaikh, Rajshekhar Karpoormath, Jagannath Jadhav, Deepak Phal, Nitin G. Ghatpande, and Prafulla B. Choudhari
- Subjects
Polymers and Plastics ,010405 organic chemistry ,Organic Chemistry ,Anti-Microbial Agents ,Condensation ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Chromane ,Biological evaluation ,Acetophenone - Abstract
An efficient and convenient method for the synthesis of a novel N-acyl/aroyl spiro[chromane-2,4′-piperidin]-4(3H)-one analogue was developed via two stage condensation of α-hydroxy acetophenone wit...
- Published
- 2021
46. N-Selenocyanato-Dibenzenesulfonimide: A New Electrophilic Selenocyanation Reagent
- Author
-
Ai-Hui Ye, Deng Zhu, and Zhi-Min Chen
- Subjects
Tandem ,010405 organic chemistry ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Nucleophile ,Organoselenium Compound ,Reagent ,Electrophile ,Chromane ,Lewis acids and bases ,Phenols - Abstract
A new electrophilic selenocyanation reagent N-selenocyanato-dibenzenesulfonimide was readily prepared in two steps from commercially available dibenzenesulfonimide for the first time. A variety of electrophilic selenocyanato reactions of nucleophiles have been achieved using it as selenocyanato source under mild and simple conditions. Numerous SeCN-containing compounds were obtained in moderate to excellent yields. Meanwhile, a Lewis acid mediated tandem selenocyanation/cyclization reaction of alkenes with phenols, which provided simple methods for the formation of various SeCN-containing chromanes and dihydrobenzofurans in moderate to good yields, has also been developed.
- Published
- 2021
47. Concise Synthesis of Chromene/Chromane-Type Aryne Precursors and Their Applications
- Author
-
Feng Sha, Xin-Yan Wu, Jia-Wei Tian, Yuan-Ze Xu, and Qiong Li
- Subjects
Nucleophilic addition ,Cycloaddition Reaction ,Molecular Structure ,010405 organic chemistry ,Chemistry ,Aryl ,Organic Chemistry ,Regioselectivity ,010402 general chemistry ,Triple bond ,01 natural sciences ,Combinatorial chemistry ,Aryne ,Cycloaddition ,0104 chemical sciences ,chemistry.chemical_compound ,Chromane ,Benzopyrans - Abstract
The gram-scale synthesis of 5,6-, 6,7-, and 7,8-chromene/chromane-type aryne precursors and their applications in regioselective transformation to other functional derivatives is reported. Chromene/chromane-type arynes are generated under mild conditions, which can further undergo [2 + 2], [3 + 2], and [4 + 2] cycloaddition reactions, nucleophilic addition reactions, and σ-insertion reactions to produce structurally novel substituted chromenes and chromanes. The excellent regioselectivity of the reaction is facilitated by the oxygen-containing guiding groups at the ortho-position of the triple bond, which can be removed or switched to other functional groups including alkenyl, aryl, heteroaryl, and arylamino groups.
- Published
- 2021
48. Intramolecular Oxidative Coupling between Unactivated Aliphatic C–H and Aryl C–H Bonds
- Author
-
Feng Liu, Zhangjie Shi, Zhen Zhang, Junzhen Fan, Yi Zhou, and Yang Liao
- Subjects
010405 organic chemistry ,Aryl ,Organic Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Intramolecular force ,Polymer chemistry ,Chromane ,Oxidative coupling of methane ,Tetralin ,Physical and Theoretical Chemistry - Abstract
Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this article, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.
- Published
- 2021
49. Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C–H/C–H Coupling: Four-Step Total Synthesis of (±)-Russujaponol F
- Author
-
Shuang Liu, Jin-Quan Yu, Alastair N. Herron, and Zhe Zhuang
- Subjects
Pivalic acid ,Molecular Structure ,Tetrahydronaphthalenes ,Indane ,Total synthesis ,Stereoisomerism ,General Chemistry ,Sodium percarbonate ,Phenylacetic acid ,Biochemistry ,Combinatorial chemistry ,Article ,Catalysis ,Coupling reaction ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Cyclization ,Indans ,Organometallic Compounds ,Chromane ,Chromans ,Cyclopentane - Abstract
The development of practical C−H/C−H coupling reactions remains a challenging yet appealing synthetic venture because it circumvents the need to prefunctionalize both coupling partners for the generation of C−C bonds. Herein, we report a cyclative C(sp3)−H/C(sp2)−H coupling reaction of free aliphatic acids enabled by a cyclopentane-based mono-N-protected β-amino acid ligand. This reaction uses inexpensive sodium percarbonate (Na2CO3·1.5H2O2) as the sole oxidant, generating water as the only byproduct. A range of biologically important scaffolds, including tetralins, chromanes, and indanes, could be easily prepared by this protocol. Finally, the synthetic application of this methodology is demonstrated by the concise total synthesis of (±)-russujaponol F in a four-step sequence starting from readily available phenylacetic acid and pivalic acid through the sequential functionalizations of four C−H bonds.
- Published
- 2021
50. Nanostructured coumarin-based cobalt complex as an efficient, heterogeneous and recyclable catalyst for the three-component synthesis of benzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives
- Author
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Fatemeh Sabzalizadeh, Seyyede Faeze Razavi, Hashem Sharghi, Hamid Reza Karbalaei-Heidari, and Mahdi Aberi
- Subjects
010405 organic chemistry ,Aryl ,General Chemistry ,010402 general chemistry ,Heterogeneous catalysis ,Coumarin ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,Solvent ,chemistry.chemical_compound ,chemistry ,Pyran ,Chromane ,Malononitrile - Abstract
An improved one-pot three-component reaction of carbonyl compounds (dimedon, 4-hydroxy coumarin and 1,3-cyclohexadion) with malononitrile and aryl aldehydes in aqueous media (H2O:EtOH) as a solvent with short reaction time for the synthesis of benzo[b]pyran and 3,4- dihydropyrano[c]chromane derivatives by using nanostructured coumarin-based cobalt complex as an efficient heterogeneous catalyst. The salient features of this new protocol include simple procedure, high yields, easy isolation of products without need to column chromatography and short reaction times. Also, the nanocatalyst was recovered by adding EtOH and reused five times without significant loss of its catalytic activity. Biological impact assessments of the complex were conducted by DNA cleavage ability assay and eukaryotic cell toxicity measurement. Although the complex showed single-strand DNA breakage under oxidative conditions, its high polar nature revealed a marked decrease in cell toxicity data due to the restriction on cell entry.
- Published
- 2021
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