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Your search keyword '"Chowdhury Turin T"' showing total 5 results
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5 results on '"Chowdhury Turin T"'

1. Change in GFR and Subsequent Mortality: Meta-Analysis of 32 Cohorts in the CKD Prognosis Consortium

Author

Chowdhury Turin T, Matsushita K, Coresh J, Arima H, Chadban SJ, Cirillo M, Djurdjev O, Green JA, Irie F, Ix JH, Kovesdy CP, Ohkubo T, Wen CP, de Jong PE, Iseki K, Stengel B, Gansevoort RT., Chowdhury Turin, T, Matsushita, K, Coresh, J, Arima, H, Chadban, Sj, Cirillo, M, Djurdjev, O, Green, Ja, Irie, F, Ix, Jh, Kovesdy, Cp, Ohkubo, T, Wen, Cp, de Jong, Pe, Iseki, K, Stengel, B, and Gansevoort, Rt.

Abstract

Background: Change in estimated GFR (eGFR) is frequently used to track CKD progression in clinical practice, trials and cohort studies but its association with mortality has not been studied extensively. Methods: Change in eGFR was estimated as % change from the rst to last eGFR (CKD-EPI creatinine) in a 2-year baseline period. We modeled the hazard ratios (HRs) of subsequent mortality as a spline function of %change in eGFR after adjusting for age, sex, race, rst eGFR, and co-morbid conditions. We used random effects meta-analyses to combine results strati ed by rst baseline eGFR (

Published
2013

4. Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease.

Author

Okada R, Kawai S, Naito M, Hishida A, Hamajima N, Shinchi K, Chowdhury Turin T, Suzuki S, Mantjoro EM, Toyomura K, Arisawa K, Kuriyama N, Hosono S, Mikami H, Kubo M, Tanaka H, and Wakai K

Subjects
Adult, Aged, Cross-Sectional Studies, Humans, Middle Aged, Prevalence, Matrix Metalloproteinase 9 genetics, Polymorphism, Genetic, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic genetics, Tissue Inhibitor of Metalloproteinases genetics
Abstract

Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression., Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m(2)) was compared among the genotypes., Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9 -1562T/279R/668Q showed a reduced risk for CKD compared with the most common -1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination -1562TT/ 279RR/668QQ showed a halved risk for CKD compared with major allele homozygous -1562CC/279RR/668RR (OR 0.53, p = 0.091)., Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases., (Copyright © 2012 S. Karger AG, Basel.)

Published
2012
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5. Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).

Author

Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y, Chowdhury Turin T, Horie M, Miki T, and Ueshima H

Subjects
Female, Genetic Predisposition to Disease ethnology, Humans, Japan epidemiology, Male, Asian People statistics & numerical data, Cardiovascular Diseases ethnology, Cardiovascular Diseases genetics, Polymorphism, Genetic, Receptor, Angiotensin, Type 1 genetics
Abstract

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR)=1.13; 95% confidence interval (CI): 1.10-1.16; p<0.0001) and sex (HR=2.18; 95%CI: 1.23-3.85; p=0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR=1.11; 95%CI: 0.61-2.02; p=0.731).

Published
2009
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