1. Change in GFR and Subsequent Mortality: Meta-Analysis of 32 Cohorts in the CKD Prognosis Consortium
- Author
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Chowdhury Turin T, Matsushita K, Coresh J, Arima H, Chadban SJ, Cirillo M, Djurdjev O, Green JA, Irie F, Ix JH, Kovesdy CP, Ohkubo T, Wen CP, de Jong PE, Iseki K, Stengel B, Gansevoort RT., Chowdhury Turin, T, Matsushita, K, Coresh, J, Arima, H, Chadban, Sj, Cirillo, M, Djurdjev, O, Green, Ja, Irie, F, Ix, Jh, Kovesdy, Cp, Ohkubo, T, Wen, Cp, de Jong, Pe, Iseki, K, Stengel, B, and Gansevoort, Rt.
- Abstract
Background: Change in estimated GFR (eGFR) is frequently used to track CKD progression in clinical practice, trials and cohort studies but its association with mortality has not been studied extensively. Methods: Change in eGFR was estimated as % change from the rst to last eGFR (CKD-EPI creatinine) in a 2-year baseline period. We modeled the hazard ratios (HRs) of subsequent mortality as a spline function of %change in eGFR after adjusting for age, sex, race, rst eGFR, and co-morbid conditions. We used random effects meta-analyses to combine results strati ed by rst baseline eGFR (
- Published
- 2013