Back to Search Start Over

Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study).

Authors :
Tamaki S
Nakamura Y
Tabara Y
Okamura T
Kanda H
Kita Y
Kadowaki T
Tsujita Y
Chowdhury Turin T
Horie M
Miki T
Ueshima H
Source :
International journal of cardiology [Int J Cardiol] 2009 Aug 21; Vol. 136 (3), pp. 354-5. Date of Electronic Publication: 2008 Aug 03.
Publication Year :
2009

Abstract

We examined whether the A1166C polymorphism of the angiotensin II type I receptor gene (AGTR1) affects cardiovascular event occurrence in a Japanese prospective cohort study. The 2212 participants who gave informed consent for genetic analysis were enrolled in this study (the Shigaraki Study). The average observation period was 1954 days. Cardiovascular events occurred in 37 individuals (1.7%). The independent factors which specified cardiovascular events were age (hazard ratio (HR)=1.13; 95% confidence interval (CI): 1.10-1.16; p<0.0001) and sex (HR=2.18; 95%CI: 1.23-3.85; p=0.007). However, the A1166C polymorphism of AGTR1 was not a predictive factor for cardiovascular events (HR=1.11; 95%CI: 0.61-2.02; p=0.731).

Details

Language :
English
ISSN :
1874-1754
Volume :
136
Issue :
3
Database :
MEDLINE
Journal :
International journal of cardiology
Publication Type :
Editorial & Opinion
Accession number :
18676046
Full Text :
https://doi.org/10.1016/j.ijcard.2008.04.079