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An investigation of the interaction between chlorpromazine (CPZ) and monolayers of 1,2-dipalmitoyl-sn-3-glycerophosphatidylcholine (DPPC) and 1,2-dipalmitoyl-sn-3-glycero[phospho-rac-(1-glycerol)] (DPPG), both at the air/water interface and in transferred Langmuir-Blodgett films is presented. The IR and compressibility results demonstrate that the effect from CPZ could not be correlated with temperature changes in the subphase for pure monolayers, in contrast to models proposed by other authors.

Ceramic carbon materials were developed as new sorbents for solid-phase extraction of organic compounds using chlorpromazine as a representative. The macroporosity and heterogeneity of ceramic carbon materials allow extracting a large amount of chlorpromazine over a short time. Thus, the highly sensitive and selective determination of chlorpromazine in urine sample was achieved by differential pulse voltammograms after only 1-min extraction. The total analysis time was less than 3 min. In comparison with other electrochemical and electrochemi-luminescent methods following 1-min extraction, the proposed method improved sensitivity by about 2 and 1 order of magnitude, respectively. The fast extraction, diversity, and conductivity of ceramic carbon materials make them promising sorbents for various solid-phase extractions, such as solid-phase microextraction, thin-film microextraction, and electrochemically controlled solid-phase extraction. The preliminary applications of ceramic carbon materials in chromatography were also studied.

A forensic chemistry exercise in which model compounds are used to stimulate the behavior of various drugs in a series of chemical tests is described. The exercise involves the structural study of chlorpromazine with three V-like ring formations and deformation of approximately 50 degrees from planarity.