Thermodynamic and infrared analyses of the interaction of chlorpromazine with phospholipid monolayers

An investigation of the interaction between chlorpromazine (CPZ) and monolayers of 1,2-dipalmitoyl-sn-3-glycerophosphatidylcholine (DPPC) and 1,2-dipalmitoyl-sn-3-glycero[phospho-rac-(1-glycerol)] (DPPG), both at the air/water interface and in transferred Langmuir-Blodgett films is presented. The IR and compressibility results demonstrate that the effect from CPZ could not be correlated with temperature changes in the subphase for pure monolayers, in contrast to models proposed by other authors.