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2. Bovine lactoferrin for Helicobacter pylori eradication: an open, randomized, multicentre study

Author

DI MARIO, F., ARAGONA, G., DAL BÓ, N., CAVALLARO, L., MARCON, V., OLIVIERI, P., BENEDETTI, E., ORZÈS, N., MARIN, R., TAFNER, G., CHILOVI, F., DE BASTIANI, R., FEDRIZZI, F., FRANCESCHI, M., SALVAT, M. H., MONICA, F., PIAZZI, L., VALIANTE, F., VECCHIATI, U., CAVESTRO, G. M., COMPARATO, G., IORI, V., MAINO, M., LEANDRO, G., PILOTTO, A., RUGGE, M., and FRANZÈ, A.

Published
2006

3. PANTOPRAZOLE IN ERADICATION OF PEPTIC ULCER H PYLORI (H PYLORI) POSITIVE PATIENTS: A MULTICENTRE RANDOMISED PROSPECTIVE STUDY BY GISU (INTERDISCIPLINARY ULCER STUDY GROUP)

Author

Di Mario, F., Dal Bo', N., Battaglia, G., Benedetti, E., Bottona, E., Caroli, A., Chilovi, F., Costan, F., De Bastiani, R., De Berardinis, F., De Pretis, G., De Bernardin, M., Fedrizzi, F., Franceshi, M., Germanà, B., Grassi, S. A., Magalini, M., Marcon, V., Marin, R., Meggiato, T., Melina, V., Monica, F., Orzes, N., Piazzi, L., Pilotto, A., Ronzani, G., Salandin, S., Saggioro, A., Tafner, G., Vianello, F., and Vecchiati, U.

Published
1999

4. Italian consensus guidelines for chronic pancreatitis

Author

Frulloni, L, Falconi, M, Gabbrielli, A, Gaia, E, Graziani, R, Pezzilli, R, Uomo, G, Andriulli, A, Balzano, G, Benini, L, Calculli, L, Campra, D, Capurso, G, Cavestro, Gm, De Angelis, C, Ghezzo, L, Manfredi, R, Malesci, A, Mariani, A, Mutignani, M, Ventrucci, M, Zamboni, G, Amodio, A, Vantini, I, Bassi, C, Delle Fave, G, Capurso, Iv, Magarini, F, Albarello, L, Alfieri, S, Anti, M, Arcidiacono, P, Baiocchi, L, Berretti, D, Boraschi, P, Buscarini, E, Carroccio, A, Celebrano, Mr, Casadei, R, Chilovi, F, Conigliaro, R, Dall'Oglio, L, De Boni, M, De Pretis, G, Di Priolo, S, Di Sebastiano PL, Doglietto, Gb, Filauro, M, Frieri, G, Fuini, A, Loriga, P, Macarri, G, Manes, G, Massucco, P, Milani, S, Pasquali, Claudio, Pederzoli, P, Pietrangeli, M, Rocca, R, Russello, D, Siquini, W, Traina, M, Veneroni, L, Zilli, M, Italian Association for the Study of the Pancreas, Frulloni L, Falconi M, Gabbrielli A, Gaia E, Graziani R, Pezzilli R, Uomo G, Andriulli A, Balzano G, Benini L, Calculli L, Campra D, Capurso G, Cavestro GM, De Angelis C, Ghezzo L, Manfredi R, Malesci A, Mariani A, Mutignani M, Ventrucci M, Zamboni G, Amodio A, Vantini I, Italian Association for the Study of the Pancreas (AISP), Bassi C, Delle Fave G, Capurso IV, Magarini F, Albarello L, Alfieri S, Anti M, Arcidiacono P, Baiocchi L, Berretti D, Boraschi P, Buscarini E, Carroccio A, Celebrano MR, Casadei R, Chilovi F, Conigliaro R, Dall'Oglio L, De Boni M, De Pretis G, Di Priolo S, Di Sebastiano PL, Doglietto GB, Filauro M, Frieri G, Fuini A, Loriga P, Macarri G, Manes G, Massucco P, Milani S, Pasquali C, Pederzoli P, Pietrangeli M, Rocca R, Russello D, Siquini W, Traina M, Veneroni L, Zilli M, Zamboni G., Frulloni, L, Falconi, M, Gabbrielli, A, Gaia, E, Graziani, R, Pezzilli, R, Uomo, G, Andriulli, A, Balzano, G, Benini, L, Calculli, L, Campra, D, Capurso, G, Cavestro, Gm, De Angelis, C, Ghezzo, L, Manfredi, R, Malesci, A, Mariani, A, Mutignani, M, Ventrucci, M, Zamboni, G, Amodio, A, Vantini, I, Italian Association for the Study of the Pancreas, (AISP), Bassi, C, Delle Fave, G, Capurso, Iv, Magarini, F, Albarello, L, Alfieri, S, Anti, M, Arcidiacono, P, Baiocchi, L, Berretti, D, Boraschi, P, Carroccio, A, Celebrano, Mr, Casadei, R, Chilovi, F, Conigliaro, R, Dall'Oglio, L, De Boni, M, De Pretis, G, Di Priolo, S, Di Sebastiano, Pl, Doglietto, Gb, Filauro, M, Frieri, G, Fuini, A, Macarri, G, Manes, G, Massucco, P, Milani, S, Pasquali, C, Pederzoli, P, Pietrangeli, M, Rocca, R, Russello, D, Siquini, W, Traina, M, Veneroni, L, Zilli, M, and Zamboni, G.

Subjects
medicine.medical_specialty, complications, pancreatic supplements, diagnostic imaging, pancreatitis, MEDLINE, cholangiopancreatography, chronic, endoscopic retrograde, pain, quality of life, radiography, sphincterotomy, steatorrhea, surgery, therapy, ultrasonography, Appropriate use, guidelines, chronica pancreatitis, Pancreatitis, Chronic, Pancreatitis, chronic, Complications, Surgery, Medical imaging, Medicine, Humans, Pancreatic stones, Intensive care medicine, Surgical treatment, Hepatology, medicine.diagnostic_test, business.industry, Pancreatitis, Radiography, Therapy, Ultrasonography, Cholangiopancreatography, Sphincterotomy, Diagnostic imaging, Pain, Quality of life, Steatorrhea, Pancreatic supplements, Gastroenterology, medicine.disease, Endoscopy, Pancreatic pain, Italy, CHRONIC PANCREATITIS, Radiology, business
Abstract

This paper gives practical guidelines for diagnosis and treatment of chronic pancreatitis. Statements have been elaborated by working teams of experts, by searching for and analysing the literature, and submitted to a consensus process by using a Delphi modified procedure. The statements report recommendations on clinical and nutritional approach, assessment of pancreatic function, treatment of exocrine pancreatic failure and of secondary diabetes, treatment of pain and prevention of painful relapses. Moreover, the role of endoscopy in approaching pancreatic pain, pancreatic stones, duct narrowing and dilation, and complications was considered. Recommendations for most appropriate use of various imaging techniques and of ultrasound endoscopy are reported. Finally, a group of recommendations are addressed to the surgical treatment, with definition of right indications, timing, most appropriate procedures and techniques in different clinical conditions and targets, and clinical and functional outcomes following surgery. © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Keywords: Pancreatitis, chronic; Complications; Surgery; Radiography; Therapy; Ultrasonography; Cholangiopancreatography

Published
2010

5. Low risk of colon cancer in patients with celiac disease

Author

Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, GR, Sandri, G, Giorgetti, G, Caio, G, Lo Perfido, S, Perri F, Festa V, Pelli MA, Cavalletti ML, Segato S, Curzio M, Pennazio M, Rossini FP, Picarelli A, Pera A, Ercole E, Passaleva MT, Barbato M, Usai P, Dore MF, Chilovi F, Piazzi L, Zancanella L, Boarino V, Ferrari A., GRECO, LUIGI, AURICCHIO, SALVATORE, Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Greco, Luigi, Auricchio, Salvatore, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, Gr, Sandri, G, Giorgetti, G, Caio, G, Lo, Perfido, S, Perri, F, Festa, V, Pelli, Ma, Cavalletti, Ml, Segato, S, Curzio, M, Pennazio, M, Rossini, Fp, Picarelli, A, Pera, A, Ercole, E, Passaleva, Mt, Barbato, M, Usai, P, Dore, Mf, Chilovi, F, Piazzi, L, Zancanella, L, Boarino, V, Ferrari, A., Volta U, Vincentini O, Quintarelli F, Felli C, Silano M, and Collaborating Centres of the Italian Registry of the Complications of Celiac Disease

Subjects
Male, Colorectal cancer, COLON CANCER, Disease, Gastroenterology, Colon carcinoma, Retrospective Studie, Medicine, Child, Colonic Neoplasm, education.field_of_study, Medicine (all), Incidence, Celiac disease, Gluten-free diet, Adolescent, Adult, Carcinoma, Celiac Disease, Child, Preschool, Colonic Neoplasms, Diet, Gluten-Free, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Italy, Middle Aged, Patient Compliance, Retrospective Studies, Risk Assessment, Young Adult, Population study, Human, Cohort study, medicine.medical_specialty, Population, Follow-Up Studie, NO, Internal medicine, In patient, Preschool, education, business.industry, Newborn, medicine.disease, digestive system diseases, Diet, Standardized mortality ratio, Gluten-Free, Celiac disease, colon carcinoma, gluten-free diet, business
Abstract

Objective. Celiac disease (CD) has strongly been established as associated with some site-specific gastrointestinal malignancies. On the contrary, according to the few reports available, the risk of colon carcinoma in CD patients has been described similar to that of general population. In this cohort study, we describe the risk of colon carcinoma in a group of Italian celiac patients. Materials and methods. The study population included all CD patients diagnosed at the Collaborating Centers of the Italian Registry of CD between 1st January 1982 and 31st December 2006. Upon diagnosis of CD and upon at every subsequent clinical control, the Collaborating Centers filled in a validated form for each CD patient reporting information about demographic data, possible occurrence of a neoplasm and adherence to a gluten-free diet. Results. Out of 1757 celiac patients enrolled, 6 developed a colon carcinoma during the follow-up period (mean: 18.1 years). The standardized incidence ratio (SIR) resulted 0.29 (95% CI = 0.07–0.45). Stratifying the risk for the dietary gluten intake, the SIR dropped to 0.07 (95% CI = 0.009–0.27) for CD patients with a strict adherence to a gluten-free diet. Conclusion. We confirm the previous finding that there is low risk to develop a colon cancer in celiac patients.

Published
2014

6. Predictive value of the 'DICA' classification on the outcome of diverticular disease of the colon

Author

Tursi, A., Brandimarte, G., Di Mario, F., Andreoli, A., Annunziata, M. L., Astegiano, M., Bianco, M. A., Buri, L., Cammarota, G., Capezzuto, E., Chilovi, F., Cianci, M., Conigliaro, R., Del Favero, G., Elisei, W., Faggiani, R., Farroni, F., Forti, G., Germanà, B., Giorgetti, G., Giovannone, M., Lecca, P. G., Marmo, R., Occhigrossi, G., Penna, A., Rossi, A. F., Spadaccini, A., Zampaletta, C., Zilli, M., Zullo, A., Altavilla, N., Carlomagno, P., Colucci, R., De Bastiani, R., Di Cesare, L., Di Fonzo, M., Efrati, C., Ferrini, L., Fortuna, M., Graziani, M. G., Latella, Giovanni, Loperfido, S., Goni, E., Manes, G., Morucci, P., Papa, A., Pigò, F., Pranzo, G., Rotondano, G., Usai, P., Picchio, M., and Scarpignato, C. .

Published
2015

7. Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease

Author

Silano, Marco, Volta, Umberto, Vincenzi, Alessandro De, Dessì, Mariarita, Vincenzi, Massimo De, Gasbarrini, G., De Vitis, V., Santini, D., F. , Scaggiante M., Vincenzi, M., Federici, Null, Castellano, E., Calvi, A., Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Volta, U., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A., GRECO, LUIGI, AURICCHIO, SALVATORE, Silano, Marco, Volta, Umberto, Vincenzi, Alessandro De, Dessì, Mariarita, Vincenzi, Massimo De, Gasbarrini, G., De Vitis, V., Greco, Luigi, Auricchio, Salvatore, Santini, D., F., Scaggiante M., Vincenzi, M., Federici, Null, Castellano, E., Calvi, A., Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Volta, U., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Male, Time Factors, Lymphoma, Physiology, Gastroenterology, Coeliac disease, Celiac disease, Enteropathy-associated T-cell lymphoma, Gluten-free diet, Child, chemistry.chemical_classification, Settore BIO/12, Middle Aged, Child, Preschool, Gluten-free diet, Enteropathy-associated T-cell lymphoma, Female, Human, Adult, medicine.medical_specialty, Intestinal Neoplasm, Glutens, Adolescent, Time Factor, Diet therapy, Malignancy, Lymphoma, T-Cell, Follow-Up Studie, Celiac disease, Celiac Disease, Follow-Up Studies, Humans, Infant, Intestinal Neoplasms, Patient Compliance, Stomach Neoplasms, Stomach Neoplasm, Internal medicine, medicine, Risk factor, Preschool, business.industry, nutritional and metabolic diseases, medicine.disease, T-Cell, Gluten, digestive system diseases, chemistry, Gluten free, business
Abstract

Patients with celiac disease have an increased rate of enteropathy-associated T-cell lymphoma, but conflicting data are available about the protective role of a gluten-free diet with regard to the development of this malignancy. We followed 1,757 celiac patients for a total period of 31,801 person-years, collecting data about the frequency of gluten intake and the incidence of the enteropathy-associated T-cell lymphoma. Out of the nine celiac patients who developed an intestinal lymphoma [standard morbidity ratio of 6.42 (95% CI = 2.9-12.2; P < 0.001)], only two kept a strict gluten-free diet after the diagnosis of celiac disease and developed the malignancy after the peridiagnosis period of 3 years, dropping therefore the standard morbidity ratio to 0.22 (95%CI = 0.02-0.88; P < 0.001). The risk of developing an intestinal lymphoma for the celiac patients that used to have dietary gluten was significant (X(2 )= 4.8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.

Published
2008

8. Delayed diagnosis of coeliac disease increases cancer risk

Author

Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, L., Auricchio, S., Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna-Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., Ferrari, A., Silano, Marco, Volta, Umberto, Mecchia, Anna, Dessì, Mariarita, Di Benedetto, Rita, De Vincenzi, Massimo, Gasbarrini, G., De Vitis, D., Greco, Luigi, Auricchio, Salvatore, Santini, D., Scaggiante, F., Federici, M. D., Castellano, E., Sategna Guidetti, Null, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, Monica, De Franceschi, L., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, A., Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Registrie, tumors, Adult, Male, Risk, medicine.medical_specialty, Time Factors, Time Factor, Delayed diagnosis, Gastroenterology, Coeliac disease, Internal medicine, Neoplasms, medicine, Neoplasm, Humans, Age Factor, In patient, Registries, lcsh:RC799-869, Coeliac disease, neoplasm, tumors, Age Factors, Celiac Disease, Female, Middle Aged, business.industry, Medicine (all), Settore BIO/12, Cancer, General Medicine, Hepatology, medicine.disease, Population study, lcsh:Diseases of the digestive system. Gastroenterology, Cancer risk, business, neoplasm, Human, Research Article
Abstract

Background The association between coeliac disease (CD) and neoplasms has been long established, but few data are available about the risk factors. The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease. Methods The study population consists of patients (n = 1968) diagnosed with CD at 20 Italian gastroenterology referral Centers between 1st January 1982 and 31st March 2005. Results The SIR for all cancers resulted to be 1.3; 95% CI = 1.0–1.7 p < 0.001. The specific SIRs for non Hodgkin lymphoma was 4.7; 95% CI = 2.9–7.3 p < 0.001, for the small bowel carcinoma 25; 95% CI = 8.5–51.4 p < 0.001, for non Hodgkin lymphoma 10; 95% CI = 2.7–25 p = 0.01, finally for the stomach carcinoma 3; 95% CI = 1.3–4.9 p < 0.08. The mean age at diagnosis of CD of patients that developed sooner or later a neoplasm was 47,6 ± 10.2 years versus 28.6 ± 18.2 years of patients who did not. Conclusion Coeliac patients have an increased risk of developing cancer in relation to the age of diagnosis of CD. This risk results higher for malignancies of the gastro-intestinal sites. An accurate screening for tumors should be performed in patients diagnosed with CD in adulthood and in advancing age.

Published
2007

9. Bovine lactoferrin as a rescure treatment for Helicobacter pylori infection: results of a multicenter study

Author

DI MARIO F, DAL B. N, ARAGONA G, MARCON V, OLIVIERI PG, MARIN R, DE BASTIANI R, PIAZZI L, CHILOVI F, FEDRIZZI F, TAFNER G, MONICA F, HERAS H, GERMAN B, FANIGLIULO L, MAZZOCCHI G, CAVALLARO LG, MAINO M, FRANZ A., CAVESTRO , GIULIA MARTINA, DI MARIO, F, DAL B., N, Aragona, G, Marcon, V, Olivieri, Pg, Marin, R, DE BASTIANI, R, Piazzi, L, Chilovi, F, Fedrizzi, F, Tafner, G, Monica, F, Heras, H, German, B, Fanigliulo, L, Mazzocchi, G, Cavallaro, Lg, Maino, M, Cavestro, GIULIA MARTINA, and Franz, A.

Published
2005

10. Efficacy of bovine lactoferrin fot Helicobacter pylori eradication: results of a multicenter study

Author

DI MARIO F, DA B. N, ARAGONA G, MARCON V, OLIVIERI PG, MARIN R, DE BASTIANI R, PIAZZI L, CHILOVI F, FEDRIZZI F, TAFNER G, VECCHIATI U, MONICA F, H, FRANCESCHI M, ORZES N, BENEDETTI E, FANIGLIULO L, MAZZOCCHI G, CAVALLARO LG, MAINO M, IORI V, FRANZ A., CAVESTRO , GIULIA MARTINA, DI MARIO, F, DA B., N, Aragona, G, Marcon, V, Olivieri, Pg, Marin, R, DE BASTIANI, R, Piazzi, L, Chilovi, F, Fedrizzi, F, Tafner, G, Vecchiati, U, Monica, F, H, Franceschi, M, Orzes, N, Benedetti, E, Fanigliulo, L, Mazzocchi, G, Cavallaro, Lg, Maino, M, Iori, V, Cavestro, GIULIA MARTINA, and Franz, A.

Published
2005

11. Diagnosis, treatment and survival of patients with hepatorenal syndrome: A survey on daily medical practice

Author

Salerno, F., Cazzaniga, M., Merli, M., Spinzi, G., Saibeni, S., Salmi, A., Fagiuoli, S., Spadaccini, A., Trotta, E., Laffi, G., Koch, M., Riggio, O., Boccia, S., Felder, M., Balzani, S., Bruno, S., Angeli, P., Gobbo, G., Monti, V., Ridola, L., Terreni, N., Facciotto, C., Olivari, N., Gaffuri, G., Russo, L., Gatta, A., Romanelli, R. G., Marra, F., Moretti, A., Mangone, M., Gullini, S., Chilovi, F., Casetti, T., Okolicsanyi, L., Alimonti, P., Pazzi, P., Salvagnini, M., Colli, A., Andreoletti, M., Leo, P., Bellis, L., Lorenzini, I., Salerno, F, Cazzaniga, M, Merli, M, Spinzi, G, Saibeni, S, Salmi, A, Fagiuoli, S, Spadaccini, A, Trotta, E, Laffi, G, Koch, M, Riggio, O, Boccia, S, Felder, M, Balzani, S, Bruno, S, and Angeli, P

Subjects
Male, medicine.medical_specialty, kidney, ascites, hepatorenal syndrome, liver cirrhosis, midodrine, portal hypertension, terlipressin, Midodrine, Cohort Studies, Spontaneous bacterial peritonitis, Hepatorenal syndrome, Albumins, Internal medicine, Ascites, Prevalence, medicine, Humans, Vasoconstrictor Agents, Prospective Studies, Prospective cohort study, Aged, Hepatology, business.industry, Mortality rate, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Italy, Ascite, Female, Liver function, medicine.symptom, business, Terlipressin, medicine.drug
Abstract

Background & Aims: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis with ascites. The International Ascites Club recommended strict diagnostic criteria and treatment with vasoconstrictors and albumin. Aim of this prospective cohort study was to investigate the prevalence of HRS, diagnostic criteria, treatment and 3-month outcome in the daily-clinical-practice. Methods: Two-hundred-fifty-three patients with cirrhosis and renal failure consecutively admitted to 21 Italian hospitals were recruited. Results: The prevalence of HRS was 45.8% (30% type-1 and 15.8% type-2). In 36% of cases HRS was presumed because not all diagnostic criteria could be fulfilled. In 8% of cases HRS was superimposed on an organic nephropathy. Patients with HRS type-1 were younger and showed higher leukocyte count, higher respiratory rates, and worse liver function scores. Sixty-four patients with HRS type-1 received vasoconstrictors (40 terlipressin and 24 midodrine/octreotide). A complete response was obtained in 19 cases (30%) and a partial response in 13 (20%). Age was the only independent predictor of response (p = 0.033). Three-month survival of patients with HRS type-1 was 19.7%. Survival was better in patients who responded to therapy. Age (p = 0.017), bilirubin (p = 0.012), and creatinine increase after diagnostic volume expansion (p = 0.02) independently predicted death. The mortality rate was 97% among patients with at least two negative predictors. Conclusions: The diagnostic criteria of HRS in our daily-clinical-practice could not be completely fulfilled in one third of cases. The treatment with vasoconstrictors and albumin was widely implemented. Mortality was strongly predicted by simple baseline variables.

Published
2011

12. Clinical features of chronic C virus hepatitis in patients with celiac disease

Author

Silano, M., Volta, U., Vincentini, O., De Vincenzi, M., Gasbarrini Italian Registry Of The Complications Of Celiac Disease, (., De Vitis, V., Greco, L., Auricchio, S., Santini, D., Scaggiante, F., Vincenzi, M., Federici, Castellano, E., Calvi, A., Sategna, Guidetti, Grosso, S., Campanella, J., Corazza, G. R., Sandri, G., Giorgetti, G., Amici, M., Parisi, C., Lo Perfido, S., Perri, F., Festa, V., Pelli, M. A., Cavalletti, M. L., Segato, S., Curzio, M., Pennazio, M., Rossini, F. P., Picarelli, Antonio, Pera, A., Ercole, E., Passaleva, M. T., Barbato, M., Usai, P., Dore, M. F., Chilovi, F., Piazzi, L., Zancanella, L., Boarino, V., and Ferrari, A.

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Hepatitis C virus, Population, Autoimmune hepatitis, medicine.disease_cause, Gastroenterology, Antiviral Agents, Coeliac disease, Primary sclerosing cholangitis, Primary biliary cirrhosis, Internal medicine, medicine, Prevalence, Humans, education, Hepatitis, education.field_of_study, Anemia, Iron-Deficiency, business.industry, Depression, General Medicine, Hepatitis C, Hepatitis C, Chronic, medicine.disease, Arthralgia, digestive system diseases, Celiac Disease, Infectious Diseases, Diabetes Mellitus, Type 2, Immunology, Female, business
Abstract

The association between celiac disease (CD) and several liver disorders has long been documented. About 40% of adult celiac patients have been reported to have mild to moderate hypertransaminasemia (up to five times the upper limit of normal) at the time of diagnosis of CD [1, 2]. In addition, CD has been found in roughly 10% of patients with unexplained hypertransaminasemia, and the majority of them have had their liver enzyme levels normalized after one year of following a strict gluten-free diet [3, 4]. In addition, an increased prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis among CD patients has been reported [5, 6]. CD might also be linked to very severe liver conditions such as end-stage liver failure and hepatocellular carcinoma [7]. There is also evidence, even contrasting reports, about the association of CD with nonalcoholic steatohepatitis and fatty liver disease [8]. In contrast, no definitive evidence is available about the association between chronic hepatitis C (hepatitis C virus [HCV]) and CD. Fine et al. described a three-fold increase of CD prevalence among HCV patients compared to noninfected celiac individuals [9]. It has also been reported the activation of silent CD during the antiviral treatment for HCV with interferon-α and ribavirin, both alone and in combination [10]. Consequently, a routine serological screening for CD has been proposed in HCV patients before starting antiviral therapy. In case of HCV positivity, the achievement of the histological normalization of the intestinal mucosa after following a gluten-free diet has been advised before starting the therapy [10]. On the contrary, some recent prospective studies have not shown increased prevalence of CD among HCV patients and reported that the link between these two conditions is biased by the route of transmission [11, 12]. Among the 3,725 celiac patients included in the Italian Registry of the Complication of Celiac Disease, we identified 34 individuals (0.91%) that had an HCV chronic hepatitis at the time of diagnosis of CD. For the diagnosis of HCV, we considered the serological positivity of antiHCV antibodies. Some of the patients had the diagnosis made in the early 1980s, when the molecular tests for the detection of the viral antigens were not yet available. The demographic and clinical features of the patients with both CD and HCV with respect to those of patients with CD only are listed in Table 1. The prevalence of HCV among our celiac series is lower than the overall prevalence of HCV among the general population in Italy, matched for age and gender, which is estimated to be around 2% [13]. This finding does not support the hypothesis of a potential correlation between these two disorders. It has been assumed that antiviral therapy with INF-α and ribavirin may precipitate the onset of CD in susceptible individuals, promoting a Th1-specific response in the small intestine [14]. However, in our series, only 12 of the 34 celiac patients with HCV had antiviral therapy before CD diagnosis. Looking at our series, it seems more likely that an overall increased risk of CD in HCV patients exists, due to the predisposition for autoimmune diseases related to Eur J Clin Microbiol Infect Dis (2009) 28:1267–1269 DOI 10.1007/s10096-009-0769-6

Published
2009

13. Colonoscopy practice in Italy: a prospective survey on behalf of the Italian Association of Hospital Gastroenterologists

Author

Radaelli, F, Meucci, G, Minoli, G, Italian Association of Hospital Gastroenterologists Alluminio, P, Amuso, M, Angelini, G, Anti, M, Baldi, F, Balzana, M, Barberani, F, Bargiggia, S, Barresi, G, Bedosti, M, Belmonte, A, Benedetti, A, Benedetti, E, Benini, M, Beretta, L, Beretta, P, Fontana, A, Mauro, B, Bianco, R, Bierti, L, Bigazzi, U, Boccia, S, Bonello, F, Boscarino, S, Bottini, E, Bresci, G, Briglia, U, Brunelli, E, Buggiani, D, Calandra, A, Candidi, A, Caneschi, F, Cannizzaro, R, Cappuccino, V, Caputi, O, Cardelli, A, Caronia, V, Cattuto, C, Cestari, E, Chilovi, F, Cifatte, D, Ciliberto, E, Cimino, F, Cipolletta, V, Cirillo, M, Cocozza, U, Colantuoni, E, Coli, A, Colombo, E, Comin, U, Conti, W, Cortini, C, Criscione, S, Crotta, S, Cutela, P, D'Imperio, N, Dalia, G, Dall'Oglio, L, Dal Pane, M, Dante, P, Dato, D, Dattola, L, De Bernardin, M, De Boni, M, De Conca, V, Dell'Amico, I, Dell'Anna, A, Della Spoletina, A, Delogu, G, Del Piano, M, Di Cicco, M, Di Filippo, G, Di Giorgio, P, Di Mitri, R, Di Piero, A, Di Piramo, D, Di Todaro, E, Dicillo, M, Dodero, C, Doldo, P, Drago, D, Dubla, G, Dughera, L, Dusio, P, Ederle, A, Evola, M, Fachinetti, F, Faraldo, G, Farroni, F, Fasoli, R, Ferrara, A, Ferrari, A, Ferrari, C, Ferraris, L, Ferraris, R, Ferrini, G, Ferrini, L, Foco, A, Forte, G, Francavilla, A, Franzè, A, Fregoni, D, Frieri, Giuseppe, Gaia, E, Galasso, F, Galgani, P, Gamberucci, G, Gatti, L, Gatti, M, Gemme, C, Ghione, S, Ghisotti, E, Giaccari, S, Giannelli, C, Giorcelli, V, Giuri, G, Giurissa, A, Grassini, M, Grasso, G, Graziani, Mg, Gualtiero, J, Gullini, S, Gullotta, R, Iaquinto, G, Jacoponi, S, Laganà, S, Lamanda, R, Lattanzio, R, Lauri, A, Lecis, Pe, Ledda, P, Leone, S, Ligas, E, Liuzzi, N, Lochis, D, Longaroni, M, Lorenzini, I, Loriga, P, Lussu, B, Luzza, F, Madia, D, Malfitana, G, Mallozzi, Ef, Mancini, S, Mangiarotti, R, Manildo, M, Manneschi, L, Marcon, V, Marino, M, Marrucci, A, Martines, H, Maruelli, A, Massari, M, Massidda, C, Mauri, R, Mazzarello, Pl, Mazzolla, E, Mellone, C, Meloni, M, Merighi, A, Mescia, P, Michetti, P, Milan, L, Milandri, G, Miori, G, Monastra, S, Moncelli, G, Monica, F, Montanaro, F, Moretti, M, Morini, S, Mosca, F, Mosca, D, Moschetta, R, Mura, G, Naim, G, Nardella, G, Natale, A, Negrini, F, Niccoli, G, Nova, A, Occhipinti, P, Ocera, S, Orlandi, Pg, Orsini, O, Pagani, E, Paliani, O, Pardocchi, D, Parodi, Cm, Pasini, D, Pasquale, L, Pasquali, L, Paterlini, A, Pellecchia, A, Pera, A, Perego, M, Perugini, B, Petracca, F, Peyre, S, Piccoli, F, Pilati, S, Pierucci, E, Pizzetti, P, Pizzolato, S, Polimeni, F, Politano, S, Polo, S, Portaluri, F, Prada, A, Privitera, U, Quaranta, S, Raguzzi, I, Ravelli, P, Recchia, S, Revetria, P, Ripoli, D, Rocca, F, Roda, E, Rogheto, M, Rosati, S, Rosina, F, Rossi, A, Rotolo, A, Sabadini, Gr, Saffiotti, O, Salerno, D, Sanesi, A, Sanna, S, Saracco, G, Savarino, V, Scaccianoce, G, Scarpulla, G, Schiffino, L, Schippa, P, Sebastiani, P, Servillo, F, Sgarbi, D, Sigillito, D, Snider, L, Sorrentini, I, Spadaccini, A, Sticchi, V, Sturniolo, Gc, Suriani, R, Tammaro, L, Tarchi, F, Tasini, E, Tebaldi, M, Terruzzi, V, Testoni, Pa, Tonelli, F, Trapè, R, Triossi, O, Usai, P, Usula, E, Vecchi, M, Vecchi, E, Ventrucci, M, Viero, K, Virgilio, C, Viviani, G, Zampaletta, U, and Zilli, M.

Subjects
Colonoscopy, Endoscopy
Published
2008

14. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole

Author

Pace, F., Annese, V., Prada, A., Zambelli, A., Casalini, S., Nardini, P., Bianchi Porro, G., Rossi, Z., Fenderico, P., Molinari, F., Molinari, A., Poletti, M., Benedetti, A., Bolognini, L., Cercamondi, P., Piergallini, S., Pieroni, N., Ridolfi, F., Palazzi, A., Agnolucci, A., Ceccatelli, P., Laurenzi, F., Grassini, M., Iaquinto, G., D'Onofrio, V., Giardullo, N., Pasquale, L., Sedici, A., Moschetta, R., Maurogiovanni, G., Costan, F., Germana, B., Lecis, P., Negrini, F., Signorelli, S., Landi, P., Malaguti, P., Roda, E., De, E., Gandolfi, L., Torresan, F., Chilovi, F., Benvenuti, S., Grasso, T., Adamo, S., Azzurro, M., Carrara, M., Rubbiani, C., P. V., Di, Di, M., Belvedere, F., Di, A., Giglio, A., De Medici, A., Rodino, S., Sacca, N., Neri, M., Carbone, F., Laterza, F., Trimboli, V., Accattatis, G. C., Rizzuti, L. F., Sabatino, A., Lupinacci, G., Faleo, D., De Francesco, V., Lombardi, L. P, Minenna, M., Nocchiero, M. C., Tonti, P., Bocchini, R., D'Imperio, N., Giaccari, S., Tronci, S., Dall'Acqua, S., Berrini, E., Garatti, S., Putignano, R., Sferrazzo, A., Giacosa, A., Blanchi, S., Munizzi, F., Morlando, L., Bruno, G., Guardascione, F., Benedetti, E., Orzes, N., Pincione, F., Dell'Amico, I., Vannucci, P., Maurano, A., Calabrese, A., Napoli, G., Quagliariello, G., Sabarese, G., Pracanica, G., Gullotti, G., Princiotta, A., Rando, L., Anderloni, A., Pallotta, S., Fesce, E., Abbiati, D., Crippa, C., Ideo, G. M., Mannucci, P. M., Abbiati, C., De Franchis, R., Fazzini, L., Rossi, A., Bini, M., Chahin, N. J., Testoni, P. A., Fossati, D., Frego, R., Passaretti, S., Catanzano, C., Siciliano, S., Sivero, L., Cattaneo, D., Di Martino, V., Inzirillo, A., Lavelli, M., Del Genio, A., Maffettone, V., Napolitano, V., Del Piano, M., Ballare, M., Garello, E., Orsello, M., Capezzuto, E., Amuso, M., Marino, M., Reina, G., Craxi, A., Arini, A., Di Pisa, M., Peralta, S., Ficano, L., Miceli, D., Tarantello, M., Orlando, A., Perego, M., Alvisi, C., Pozzi, L., Torello Viera, F., Marchi, S., Arpe, P., Bellini, M., Costa, F., Da Massa Carrara, P., Manghetti, M., Meletis, P., Romano, A., Torelli, E., Garcea, M. R., Lombardi, M., Tristaino, B., Farroni, F., Di Cicco, M., Proietti, M., Tanzilli, A., Benedetti, G., Guido, E., Lacchin, T., Sablich, R., Vitalba, A., Casetti, T., Cantoni, F., Salzetta, A., Polimeni, F., Bortoli, A., Buono, M., Gozzini, C., Barberani, F., Boschetto, S., Giovannone, M., Casale, V., Assisi, D., Grassi, A., Lapenta, R., Stigliano, V., Fedeli, G., Pirozzi, G. A., Pippa, G., Bazuro, M. E., Romano, M., Borgheresi, P., Andriulli, A., Fiorella, S., De Rocco, R., Greco, G., Meloni, M., Fina, G., Frosini, G., Macchiarelli, R., Virgilio, C., Borina, E., Lauria, M., Cappelletti, F., Puglisi, F., Ravizza, M., Emanuelli, G., Battaglia, E., Dughera, L., Navino, M., Ferrari, A., Martinoglio, P., Turco, D., Pera, A., Daperno, M., Lombardo, L., Gusmaroli, R., Milesi, F., Zilli, M., Brosolo, P., De, G., Zoratti, L., Curzio, M., Amato, A., Bisso, G., Feliziani, M., Gianfrate, L., Natale, C., Petillo, A., Spadaccini, A., Meddi, P., Sciampa, G., and Ubalducci, G. M.

Subjects
Adult, Male, Gastrointestinal, Time Factors, Severity of Illness Index, 2-Pyridinylmethylsulfinylbenzimidazoles, Endoscopy, Gastrointestinal, Helicobacter Infections, Dose-Response Relationship, Gastro-oesophageal reflux disease, Double-Blind Method, Heartburn, Esophagitis, Humans, Esophagitis, Peptic, Curative/maintenance therapy, Peptic, Hepatology, Dose-Response Relationship, Drug, Helicobacter pylori, Rabeprazole, Antacids, Anti-Ulcer Agents, Benzimidazoles, Female, Gastroesophageal Reflux, Middle Aged, Omeprazole, Patient Satisfaction, Treatment Outcome, Gastroenterology, Endoscopy, Drug
Abstract

Previous studies have shown similar effects of rabeprazole and omeprazole, when used at the same dose in the treatment of reflux oesophagitis. However, such studies have been conducted as superiority studies but interpreted as equivalence ones.To properly assess the comparative efficacy of rabeprazole and omeprazole in inducing complete endoscopic healing and symptom relief in patients with reflux oesophagitis.Patients (n=560) with Savary-Miller grade I-III reflux oesophagitis were randomised in a double-blind, double-dummy fashion to rabeprazole or omeprazole 20 mg once daily for 4-8 weeks. Then, patients endoscopically healed and symptomatically relieved were openly maintained with rabeprazole 10 mg or 2x10 mg once daily (in the event of clinical and/or endoscopic relapse) for a maximum of 48 weeks.After 4-8 weeks of treatment, healing (primary end-point) was observed in 228/233 (97.9%) patients in the rabeprazole group and in 231/237 (97.5%) in the omeprazole one (equivalence effect demonstrated by p0.0001 at Blackwelder test and an upper confidence limit at 97.5% of 0.023). However, rabeprazole was faster in inducing heartburn relief than omeprazole (2.8+/-0.2 versus 4.7+/-0.5 days of therapy to reach the first day with satisfactory heartburn relief, p=0.0045 at log-rank test). In the maintenance phase, 15.2% of patients had an endoscopic and/or clinical relapse.Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase.

Published
2005

15. OC.05.5 DEVELOPMENT AND VALIDATION OF AN ENDOSCOPIC CLASSIFICATION OF DIVERTICULAR DISEASE OF THE COLON: THE DICA CLASSIFICATION

Author

Tursi, A., primary, Brandimarte, G., additional, Di Mario, F., additional, Andreoli, A., additional, Annunziata, M.L., additional, Astegiano, M., additional, Bianco, M.A., additional, Buri, L., additional, Cammarota, G., additional, Capezzuto, E., additional, Chilovi, F., additional, Cianci, M., additional, Conigliaro, R., additional, Del Favero, G., additional, Di Cesare, L., additional, Di Fonzo, M., additional, Elisei, W., additional, Faggiani, R., additional, Farroni, F., additional, Forti, G., additional, Germanà, B., additional, Giorgetti, G., additional, Giovannone, M., additional, Lecca, P.G., additional, Loperfido, S., additional, Marmo, R., additional, Morucci, P., additional, Occhigrossi, G., additional, Penna, A., additional, Rossi, A.F., additional, Spadaccini, A., additional, Zampaletta, C., additional, Zilli, M., additional, Zullo, A., additional, and Picchio, M., additional

Published
2014
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18. OC.01.2: THE “PROMETEO” STUDY PHASE 1 & 2: CLINICAL FEATURES AND OUTCOME OF ITALIAN PATIENTS ADMITTED TO HOSPITAL FOR ACUTE NON VARICEAL UPPER GASTROINTESTINAL BLEEDING

Author

Del Piano, M., primary, Cipolletta, L., additional, Bianco, M.A., additional, Zambelli, A., additional, Chilovi, F., additional, Di Giulio, E., additional, Ricci, E., additional, Frosini, G., additional, Leo, P., additional, Di Matteo, G., additional, Ficano, L., additional, Loriga, P., additional, Prada, A., additional, Buri, L., additional, Pagliarulo, M., additional, Ballarè, M., additional, Montino, F., additional, Battisti-matscher, M., additional, and Rotondano, G., additional

Published
2011
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20. P.184 HEMODYNAMIC INSTABILITY AFFECTS CLINICAL OUTCOMES IN PATIENTS WITH NONVARICEAL UPPER GI BLEEDING (NVUGIB): ITALIAN RESULTS OF THE INTERNATIONAL “ENERGIB” STUDY

Author

Cipolletta, L., primary, Rotondano, G., additional, Bianco, M., additional, Salerno, R., additional, Andriulli, A., additional, Balzano, A., additional, Buri, L., additional, Chilovi, F., additional, Costamagna, G., additional, Del Piano, M., additional, Frosini, G., additional, Pallone, F., additional, Arena, I., additional, and Zambelli, A., additional

Published
2010
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21. P.181 ENDOSCOPIC TREATMENT OF NONVARICEAL UPPER GI BLEEDING (NVUGIB): ITALIAN RESULTS OF THE INTERNATIONAL “ENERGIB” STUDY

Author

Cipolletta, L., primary, Rotondano, G., additional, Bianco, M., additional, Salerno, R., additional, Andriulli, A., additional, Balzano, A., additional, Buri, L., additional, Chilovi, F., additional, Costamagna, G., additional, Del Piano, M., additional, Frosini, G., additional, Pallone, F., additional, Prada, A., additional, and Zambelli, A., additional

Published
2010
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23. MULTICENTER PRELIMINARY EXPERIENCE WITH “MIROCAM” CAPSULE ENDOSCOPY

Author

Pezzoli, A., primary, Fusetti, N., additional, Grasso, T., additional, Cantoni, F., additional, Di Bella, S., additional, Cantù, P., additional, Brancaccio, M.L., additional, Zancanella, L., additional, Chilovi, F., additional, Casetti, T., additional, Iaquinto, G., additional, Brunati, S., additional, Grazia, M., additional, and Gullini, S., additional

Published
2009
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24. MULTICENTER STUDY OF INTEROBSERVER AGREEMENT IN DESCRIBING CAPSULE ENDOSCOPY FINDINGS

Author

Pezzoli, A., primary, Cannizzaro, R., additional, Pennazio, M., additional, Rondonotti, E., additional, Bidoli, E., additional, Zancanella, L., additional, Cantoni, F., additional, Brancaccio, M.L., additional, Caravelli, G., additional, Melina, R., additional, Casetti, T., additional, Iaquinto, G., additional, Chilovi, F., additional, and Gullini, S., additional

Published
2009
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26. OC1.06.3 PROSPECTIVE, RANDOMIZED, DOUBLE-BLINDED, MULTICENTER STUDY COMPARING PEG VS NAP FOR CAPSULE ENDOSCOPY BOWEL PREPARATION

Author

Pezzoli, A., primary, Cannizzaro, R., additional, Fusetti, N., additional, Bidoli, E., additional, Cantoni, F., additional, Casetti, T., additional, Zancanella, L., additional, Chilovi, F., additional, Melina, R., additional, Iaquinto, G., additional, Caravelli, G., additional, Monastra, S., additional, and Gullini, S., additional

Published
2008
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27. PA.219 DOUBLE BALLOON ENTEROSCOPY (DBE) IN PATIENTS WITH OBSCURE GASTROINTESTINAL BLEEDING (OGIB) AFTER CAPSULE ENDOSCOPY (VCE)

Author

Benvenuti, S., primary, De Guelmi, A., additional, Grasso, T., additional, Zancanella, L., additional, Amplatz, S., additional, Comberlato, M., additional, Farris, P., additional, Felder, M., additional, Di Fede, F., additional, Mega, A., additional, Battisti Matscher, M., additional, Piazzi, L., additional, Bertozzo, A., additional, and Chilovi, F., additional

Published
2008
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28. CS1.4 CLINICAL FEATURES AND OUTCOME OF PATIENTS ADMITTED TO HOSPITAL FOR ACUTE NON VARICEAL UPPER GASTROINTESTINAL BLEEDING: FINAL REPORT OF THE “PROMETEO” STUDY

Author

Del Piano, M., primary, Cipolletta, L., additional, Bianco, M.A., additional, Zambelli, A., additional, Chilovi, F., additional, Di Giulio, E., additional, Ricci, E., additional, Frosini, G., additional, Leo, P., additional, Di Matteo, G., additional, Ficano, L., additional, Loriga, P., additional, Prada, A., additional, Buri, L., additional, Pagliarulo, M., additional, Ballarè, M., additional, Montino, F., additional, Battisti Matscher, M., additional, and Rotondano, G., additional

Published
2008
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33. Response

Author

Ricci, E., primary, Mortilla, M.G., additional, Conigliaro, R., additional, Bertoni, G., additional, Bedogni, G., additional, and Chilovi, F., additional

Published
1993
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42. Clinical Trial on the Efficacy of a New Symbiotic Formulation, Flortec, in Patients With Irritable Bowel Syndrome

Author

Nicoletta Garbagna, Angelo Andriulli, Sergio Cavenati, Maria Pia Cardarella, Renata Cerutti, Matteo Neri, Natalia Terreni, Sergio Gullini, Michela De Bona, Gian Luigi Milandri, Alessandro Federico, Antonio Merla, Roberto Abbiati, Carmelina Loguercio, Fausto Chilovi, Enzo Grossi, Andriulli, A, Neri, M, Loguercio, Carmelina, Terreni, N, Merla, A, Cardarella, M. P., Federico, Alessandro, Chilovi, F, Milandri, G. L., DE BONA, M, Cavenati, S, Gullini, S, Abbiati, R, Garbagna, N, Cerutti, R, and Grossi, E.

Subjects
Adult, Male, medicine.medical_specialty, Diet therapy, Glutamine, Population, Oligosaccharides, Placebo, Gastroenterology, law.invention, Irritable Bowel Syndrome, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, education, Irritable bowel syndrome, education.field_of_study, business.industry, Probiotics, Drug Synergism, Middle Aged, medicine.disease, Clinical trial, Lactobacillus, Diarrhea, Treatment Outcome, Defecation, Female, medicine.symptom, business
Abstract

Objectives: Efficacy of symbiotics in patients with irritable bowel syndrome (IBS) remains unknown. Methods: Patients were randomized to a prebiotic (n = 135), or a symbiotic formulation containing Lactobacillus paracasei B21060 (Flortec, n = 132). Primary efficacy was the responder rate for pain and global relief of symptoms in the overall population and in patients with predominant diarrhea (n = 47). Post hoc time-trend analyses for changes within each treatment were carried out. Results: Patients with absent/mild pain amounted to 54.7% in the symbiotic group and to 57.4% in the prebiotic group at treatment week 4, and to 53.9% and 53.4% at the end of treatment. Patients with amelioration of well-being were, respectively, 60.7% versus 61.7% at treatment week 4, and 63.3% versus 60.9% at the end of treatment. Within each treatment group, patients with absent/mild pain increased in the Flortec and the prebiotic group, but time trend analyses were significant only for Flortec (P = 0.019). In IBS-predominant diarrhea, Flortec significantly reduced bowel movements, pain, and IBS scores. Conclusions: To improve pain and well-being, Flortec is encouraging in patients with diarrhea predominant IBS. To establish its efficacy for the majority of IBS patients, Flortec has to be compared with an inert placebo in future work.

Published
2008

43. Development and validation of an endoscopic classification of diverticular disease of the colon: the DICA classification.

Author

Tursi A, Brandimarte G, Di Mario F, Andreoli A, Annunziata ML, Astegiano M, Bianco MA, Buri L, Cammarota G, Capezzuto E, Chilovi F, Cianci M, Conigliaro R, Del Favero G, Di Cesare L, Di Fonzo M, Elisei W, Faggiani R, Farroni F, Forti G, Germanà B, Giorgetti GM, Giovannone M, Lecca PG, Loperfido S, Marmo R, Morucci P, Occhigrossi G, Penna A, Rossi AF, Spadaccini A, Zampaletta C, Zilli M, Zullo A, Scarpignato C, and Picchio M

Subjects
Edema complications, Edema pathology, Humans, Predictive Value of Tests, Reproducibility of Results, Colon pathology, Diverticulum classification, Diverticulum complications, Endoscopy, Inflammation complications, Inflammation pathology
Abstract

Background: A validated endoscopic classification of diverticular disease (DD) of the colon is lacking at present. Our aim was to develop a simple endoscopic score of DD: the Diverticular Inflammation and Complication Assessment (DICA) score., Methods: The DICA score for DD resulted in the sum of the scores for the extension of diverticulosis, the number of diverticula per region, the presence and type of inflammation, and the presence and type of complications: DICA 1 (≤ 3), DICA 2 (4-7) and DICA 3 (>7). A comparison with abdominal pain and inflammatory marker expression was also performed. A total of 50 videos of DD patients were reassessed in order to investigate the predictive role of DICA on the outcome of the disease., Results: Overall agreement in using DICA was 0.847 (95% confidence interval, CI, 0.812-0.893): 0.878 (95% CI 0.832-0.895) for DICA 1, 0.765 (95% CI 0.735-0.786) for DICA 2 and 0.891 (95% CI 0.845-0.7923) for DICA 3. Intra-observer agreement (kappa) was 0.91 (95% CI 0.886-0.947). A significant correlation was found between the DICA score and C-reactive protein values (p = 0.0001), as well as between the median pain score and the DICA score (p = 0.0001). With respect to the 50 patients retrospectively reassessed, occurrence/recurrence of disease complications was recorded in 29 patients (58%): 10 (34.5%) were classified as DICA 1 and 19 (65.5%) as DICA 2 (p = 0.036)., Conclusions: The DICA score is a simple, reproducible, validated and easy-to-use endoscopic scoring system for DD of the colon., (© 2014 S. Karger AG, Basel.)

Published
2015
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44. The "Prometeo" study: online collection of clinical data and outcome of Italian patients with acute nonvariceal upper gastrointestinal bleeding.

Author

Del Piano M, Bianco MA, Cipolletta L, Zambelli A, Chilovi F, Di Matteo G, Pagliarulo M, Ballarè M, and Rotondano G

Subjects
Adult, Age Factors, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Blood Transfusion, Comorbidity, Endoscopy, Gastrointestinal, Female, Gastrointestinal Hemorrhage diagnosis, Gastrointestinal Hemorrhage mortality, Gastrointestinal Hemorrhage therapy, Helicobacter Infections epidemiology, Hemostasis, Endoscopic, Humans, Incidence, Italy epidemiology, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neoplasms epidemiology, Odds Ratio, Peptic Ulcer Hemorrhage epidemiology, Prospective Studies, Recurrence, Risk Assessment, Risk Factors, Sex Factors, Shock epidemiology, Stomach Ulcer epidemiology, Time Factors, Treatment Outcome, Gastrointestinal Hemorrhage epidemiology
Abstract

Goals: To implement an online, prospective collection of clinical data and outcome of patients with acute nonvariceal upper gastrointestinal bleeding (UGIB) in Italy ("Prometeo" study)., Background: Epidemiology, clinical features, and outcomes of nonvariceal UGIB are mainly known by retrospective studies and are probably changing., Study: Data were collected by 13 Gastrointestinal Units in Italy from June 2006 to June 2007 (phase 1) and from December 2008 to December 2009 (phase 2): an interim analysis of data was performed between the 2 phases to optimize the online database. All the patients consecutively admitted for acute nonvariceal UGIB were enrolled. Demographic and clinical data were collected, a diagnostic endoscopy performed, with endoscopic hemostasis if indicated., Results: One thousand four hundred thirteen patients (M=932, mean age±SD=66.5±15.8; F=481, mean age±SD=74.2±14.6) were enrolled. Comorbidities were present in 83%. 52.4% were treated with acetyl salicylic acid or other nonsteroidal anti-inflammatory drugs (NSAIDs): only 13.9% had an effective gastroprotection. Previous episodes of UGIB were present in 13.3%. Transfusion were needed in 43.9%. Shock was present in 9.3%. Endoscopic diagnosis was made in 93.2%: peptic lesions were the main cause of bleeding (duodenal ulcer 36.2%, gastric ulcer 29.6%, gastric/duodenal erosions 10.9%). At endoscopy, Helicobacter pylori was searched in 37.2%, and found positive in 51.3% of tested cases. Early rebleeding was observed in 5.4%: surgery was required in 14.3% of them. Bleeding-related death occurred in 4.0%: at multivariate analysis, the risk of death was correlated with female sex [odds ratio (OR=2.19, P=0.0089)], presence of neoplasia (OR=2.70, P=0.0057) or multiple comorbidities (OR=5.04, P=0.0280), shock at admission (OR=4.55, P=0.0001), and early rebleeding (OR=1.47, P=0.004)., Conclusions: Prometeo database has provided an up-to-date picture of acute nonvariceal UGIB in Italy: patients are elderly, predominantly males, and with important comorbidities. Gastroprotection is underutilized during NSAIDs treatment. With respect to previous studies, Prometeo shows a higher incidence of low-dose acetyl salicylic acid use and comorbidities, whereas no significant difference were found in other items (etiology of bleeding, NSAIDs use, need for endoscopic hemostasis, incidence of rebleeding, and overall mortality).

Published
2013
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46. Occult gastrointestinal bleeding in patients with a left ventricular assist device axial flow pump: diagnostic tools and therapeutic algorithm.

Author

Tarzia V, Dal Lin C, Bottio T, Benvenuti S, Chilovi F, and Gerosa G

Subjects
Aged, Capsule Endoscopy, Gastrointestinal Hemorrhage etiology, Heart Failure physiopathology, Humans, Male, Predictive Value of Tests, Treatment Outcome, Algorithms, Argon Plasma Coagulation, Double-Balloon Enteroscopy, Gastrointestinal Hemorrhage diagnosis, Gastrointestinal Hemorrhage therapy, Heart Failure therapy, Heart-Assist Devices adverse effects, Occult Blood, Ventricular Function, Left
Published
2012
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47. Interobserver agreement in describing video capsule endoscopy findings: a multicentre prospective study.

Author

Pezzoli A, Cannizzaro R, Pennazio M, Rondonotti E, Zancanella L, Fusetti N, Simoni M, Cantoni F, Melina R, Alberani A, Caravelli G, Villa F, Chilovi F, Casetti T, Iaquinto G, D'imperio N, and Gullini S

Subjects
Angiodysplasia diagnosis, Angiodysplasia epidemiology, Gastrointestinal Hemorrhage etiology, Humans, Intestinal Diseases complications, Intestinal Polyps diagnosis, Intestinal Polyps epidemiology, Italy epidemiology, Observer Variation, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Capsule Endoscopy, Gastrointestinal Hemorrhage diagnosis, Gastrointestinal Hemorrhage epidemiology, Intestinal Diseases diagnosis, Intestinal Diseases epidemiology
Abstract

Background and Aim: Few studies have specifically addressed interobserver agreement in describing lesions identified during capsule endoscopy. The aim of our study is to evaluate interobserver agreement in the description of capsule endoscopy findings., Materials and Methods: Consecutive short segments of capsule endoscopy were prospectively observed by 8 investigators. Seventy-five videos were prepared by an external investigator (gold standard). The description of the findings was reported by the investigators using the same validated and standardized capsule endoscopy structured terminology. The agreement was assessed using Cohen's kappa statistic., Results: As concerns the ability to detect a lesion, the agreement with the gold standard was moderate (kappa 0.48), as well as the agreement relating to the final diagnosis (κ 0.45). The best agreement was observed in identifying the presence of active bleeding (κ 0.72), whereas the poorest agreement concerned the lesion size (κ 0.32). The agreement with the GS was significantly better in endoscopists with higher case/volume of capsule endoscopy per year. Diagnostic concordance was better in the presence of angiectasia than in the presence of polyps or ulcers/erosions., Conclusions: Correct lesion identification and diagnosis seem more likely to occur in presence of angiectasia, and for readers with more experience in capsule endoscopy reading., (Published by Elsevier Ltd.)

Published
2011
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48. Italian consensus guidelines for chronic pancreatitis.

Author

Frulloni L, Falconi M, Gabbrielli A, Gaia E, Graziani R, Pezzilli R, Uomo G, Andriulli A, Balzano G, Benini L, Calculli L, Campra D, Capurso G, Cavestro GM, De Angelis C, Ghezzo L, Manfredi R, Malesci A, Mariani A, Mutignani M, Ventrucci M, Zamboni G, Amodio A, Vantini I, Bassi C, Delle Fave G, Frulloni L, Vantini I, Falconi M, Frulloni L, Gabbrielli A, Graziani R, Pezzilli R, Capurso IV, Cavestro GM, De Angelis C, Falconi M, Gaia E, Ghezzo L, Gabbrielli A, Graziani R, Manfredi R, Malesci A, Mariani A, Mutignani M, Pezzilli R, Uomo G, Ventrucci M, Zamboni G, Vantini I, Magarini F, Albarello L, Alfieri S, Amodio A, Andriulli A, Anti M, Arcidiacono P, Baiocchi L, Balzano G, Benini L, Berretti D, Boraschi P, Buscarini E, Calculli L, Carroccio A, Campra D, Celebrano MR, Capurso G, Casadei R, Cavestro GM, Chilovi F, Conigliaro R, Dall'Oglio L, De Angelis C, De Boni M, De Pretis G, Di Priolo S, Di Sebastiano PL, Doglietto GB, Falconi M, Filauro M, Frieri G, Frulloni L, Fuini A, Gaia E, Ghezzo L, Gabbrielli A, Graziani R, Loriga P, Macarri G, Manes G, Manfredi R, Malesci A, Mariani A, Massucco P, Milani S, Mutignani M, Pasquali C, Pederzoli P, Pezzilli R, Pietrangeli M, Rocca R, Russello D, Siquini W, Traina M, Uomo G, Veneroni L, Ventrucci M, Zilli M, and Zamboni G

Subjects
Humans, Italy, Pancreatitis, Chronic diagnosis, Pancreatitis, Chronic therapy
Abstract

This paper gives practical guidelines for diagnosis and treatment of chronic pancreatitis. Statements have been elaborated by working teams of experts, by searching for and analysing the literature, and submitted to a consensus process by using a Delphi modified procedure. The statements report recommendations on clinical and nutritional approach, assessment of pancreatic function, treatment of exocrine pancreatic failure and of secondary diabetes, treatment of pain and prevention of painful relapses. Moreover, the role of endoscopy in approaching pancreatic pain, pancreatic stones, duct narrowing and dilation, and complications was considered. Recommendations for most appropriate use of various imaging techniques and of ultrasound endoscopy are reported. Finally, a group of recommendations are addressed to the surgical treatment, with definition of right indications, timing, most appropriate procedures and techniques in different clinical conditions and targets, and clinical and functional outcomes following surgery., (Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd.. All rights reserved.)

Published
2010
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49. Digital clubbing in primary intestinal lymphangiectasia: a case report.

Author

Wiedermann CJ, Kob M, Benvenuti S, Carella R, Lucchin L, Piazzi L, Chilovi F, and Mazzoleni G

Subjects
Biopsy, Combined Modality Therapy, Diet, Fat-Restricted, Double-Balloon Enteroscopy, Enteral Nutrition, Food, Formulated, Humans, Intestine, Small pathology, Lymphangiectasis, Intestinal diagnosis, Lymphangiectasis, Intestinal diet therapy, Lymphangiectasis, Intestinal pathology, Lymphedema diagnosis, Lymphedema diet therapy, Lymphedema pathology, Male, Middle Aged, Osteoarthropathy, Secondary Hypertrophic diet therapy, Protein-Losing Enteropathies diagnosis, Protein-Losing Enteropathies diet therapy, Protein-Losing Enteropathies pathology, Osteoarthropathy, Secondary Hypertrophic etiology
Abstract

Primary intestinal lymphangiectasia (PIL), also known as Waldmann's disease, is a rare disorder characterized by dilated intestinal lacteals resulting in lymph leakage into the small bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. The symptoms usually start in early infancy. We report a case of secondary hyperparathyroidism, osteopenia, monoclonal gammopathy and digital clubbing in a 57-year-old patient with a 12-year history of discontinuous diarrhea. Malabsorption with inability to gain weight, and finally weight loss and formation of leg edema were associated with protein-losing enteropathy. A low-fat diet associated with medium-chain triglyceride supplementation was clinically effective as medical management in reducing diarrhea and leg edema, and promoting weight gain. Double-balloon enteroscopy and small bowel biopsy histopathology confirmed dilated intestinal lacteals. Digital clubbing associated with primary intestinal lymphangiectasia which may causally be related to chronic platelet excess has not been reported before.

Published
2010
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50. Diagnostic value of endoscopic markers for celiac disease in adults: a multicentre prospective Italian study.

Author

Piazzi L, Zancanella L, Chilovi F, Merighi A, De Vitis I, Feliciangeli G, Borgheresi P, Snider L, Grassi SA, Manfrini C, Orzes N, Bianco MA, Cugia L, Lenoci N, and Castagnini A

Subjects
Adult, Female, Humans, Italy, Male, Prospective Studies, Celiac Disease pathology, Duodenoscopy
Abstract

Aim: Some endoscopic features of duodenal mucosa are marker of mucosal injury, the most common cause being celiac disease (CD). The aim of this study was to prospectively assess the diagnostic value of the endoscopic markers for the diagnosis of CD in the adult population undergoing routine upper endoscopy., Methods: This was a prospective multicenter study conducted at 37 Italian endoscopic centers. A total of 509 consecutive patients submitted to routine upper endoscopy who presented one or more of following endoscopic markers were included: 1) mucosal mosaic pattern in the bulb and/or descending duodenum (DD); 2) nodularity in the bulb and/or DD; 3) scalloping of Kerkring's folds; 4) reduction in the number or absence of folds in the DD. 4 biopsies samples were taken from descending duodenum. In patients with histological findings consistent with CD, according to Oberhuber classification, sierologic test (EMA, tTGA) were performed for confirm the diagnosis., Results: At endoscopy, 249 patients showed an isolated marker; 260 subjects showed a coexistence of more than one marker; 369 patients (72.5%) presented mucosal lesions at histological examination and in 347 of these patients the diagnosis of CD was confirmed by serologic markers (94.0%). For 10 patients the diagnosis remained uncertain because of negative sierology and exclusion of other other cause of mucosal lesions. The diagnosis of CD was made in 61.3% patients who showed the mosaic pattern, in 65.7% of patients with nodular mucosa, in 64.4% of patients with scalloping of folds, in 40.2% of patients with reduction of folds, and in 61.5% of patients with loss of folds and in 83.6% of patients who showed the coexistence of more than one marker. The endoscopic markers overall had a PPV of 68% for the diagnosis of CD; the markers that singularly have demonstrated a higher correlation with CD are: mosaic mucosa of DD (PPV 65.0%), nodular mucosa of the bulb and DD (PPV 75.5%), and scalloping of folds (PPV 64.4%)., Conclusion: The study confirms the important role of endoscopy in the diagnostic process of CD not only for the bioptic sampling in patients with clinical suspicion of CD, but especially for the opportunity to evaluate alterations of the duodenal mucosa suggestive of CD in the general population and, consequently, to identify those patients who should undergo a duodenal biopsy.

Published
2008

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