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The thesis of the article by Zhaoxin Jiang, “The Untold Leader of Judicial Review: China’s Constitutional Court (1948–71) and the Innovative Constitutionalism,” is highly innovative, and the materials it uses are invaluable to understanding the Council of Grand Justices. Nonetheless, several key contentions of the article are not fully supported by—or indeed are contradicted by—the existing evidence. This Reply provides some competing analyses and interpretations of the three topics in the article: (i) the characterization of the Council at its founding; (ii) the interactions between Chiang Kai-shek and judicial elites; and (iii) the performance of the Council in Taiwan.

Research of target localization and tracking is always a remarkable problem in the application of wireless sensor networks (WSNs) technology. There are many kinds of research and applications of target localization and tracking, such as Angle of Arrival (AOA), Time of Arrival (TOA), and Time Difference of Arrival (TDOA). The target localization accuracy for TOA, TDOA, and AOA is better than RSS. However, the required devices in the TOA, TDOA, and AOA are more expensive than RSS. In addition, the computational complexity of TOA, TDOA, and AOA is also more complicated than RSS. This paper uses a particle swarm optimization (PSO) algorithm with the received signal strength index (RSSI) channel model for indoor target localization and tracking. The performance of eight different method combinations of random or regular points, fixed or adaptive weights, and the region segmentation method (RSM) proposed in this paper for target localization and tracking is investigated for the number of particles in the PSO algorithm with 12, 24, 52, 72, and 100. The simulation results show that the proposed RSM method can reduce the number of particles used in the PSO algorithm and improve the speed of positioning and tracking without affecting the accuracy of target localization and tracking. The total average localization time for target localization and tracking with the RSM method can be reduced by 48.95% and 34.14%, respectively, and the average accuracy of target tracking reaches up to 93.09%.

Two crystal structures of the histidine-containing phospho­transfer protein (HptB) and the receiver domain of the hybrid sensor histidine kinase PA1611 (PA1611REC) in the two-component regulatory system of Pseudomonas aeruginosa have been determined. With the modeled structure of the PA1611REC/HptB complex, the interactions and phospho­ryl group transfer between HptB and PA1611REC are elucidated., In Pseudomonas aeruginosa, an important opportunistic pathogen that causes numerous acute and chronic infections, the hybrid two-component system (TCS) regulates the swarming ability and biofilm formation with a multistep phospho­relay, and consists of hybrid-sensor histidine kinase (HK), histidine-containing phospho­transfer protein (Hpt) and response regulator (RR). In this work, two crystal structures of HptB and the receiver domain of HK PA1611 (PA1611REC) of P. aeruginosa have been determined in order to elucidate their interactions for the transfer of the phospho­ryl group. The structure of HptB folds into an elongated four-helix bundle – helices α2, α3, α4 and α5, covered by the short N-terminal helix α1. The imidazole side chain of the conserved active-site histidine residue His57, located near the middle of helix α3, protrudes from the bundle and is exposed to solvent. The structure of PA1611REC possesses a conventional (β/α)5 topology with five-stranded parallel β-sheets folded in the central region, surrounded by five α-helices. The divalent Mg2+ ion is located in the negatively charged active-site cleft and interacts with Asp522, Asp565 and Arg567. The HptB–PA1611REC complex is further modeled to analyze the binding surface and interactions between the two proteins. The model shows a shape complementarity between the convex surface of PA1611REC and the kidney-shaped HptB with fewer residues and a different network involved in interactions compared with other TCS complexes, such as SLN1-R1/YPD1 from Saccharomyces cerevisiae and AHK5RD/AHP1 from Arabidopsis thaliana. These structural results provide a better understanding of the TCS in P. aeruginosa and could potentially lead to the discovery of a new treatment for infection.

Most studies focusing on only one directional effect among cognitive health, physical function, and incontinence may miss potential paths. This study aimed to determine the pathway by analyzing the bidirectional effects of exposure (X) on outcome (Y) and explore the mediating effect (M) between X and Y. Secondary data analyses were performed in this study. The original data were collected from August to October 2013 in one VH in Tainan, Taiwan, and the final sample size was 144 older male veterans. Path analysis was performed to test the pathway sequence X → M → Y among the three outcome variables. Approximately 80% of the veterans were aged 81 or older, approximately 42% had a functional disability, 26% had cognitive impairment, and 20% had incontinence. The relationships between functional disability and incontinence and between functional disability and cognition impairment were bidirectional, and functional disability played a key mediating role in the relationship between cognitive impairment and incontinence. Physical more than cognitive training in order to improve or at least stabilize functional performance could be a way to prevent or reduce the process of developing incontinence.

The protrusion domain (P-domain; MrNVPd) of Macrobrachium rosenbergii nodavirus (MrNV) exists in two conformations, parallel and X-shaped. We have performed a theoretical study to gain insight into the nature of the dimeric interactions involving the dimeric interfaces within parallel and X-shaped conformations of MrNVPd by applying the quantum theory of atoms in molecules (QTAIM) and natural bond orbital (NBO) analyses in the framework of the density functional theory (DFT) approach. The results reveal that the dimer–dimer interfaces of MrNVPd have hydrogen bonds of common types. Leu255–Lys287, Tyr257–Lys287, Lys287–Ser253, Met294–Cys328, Asp295–Lys327, Ser298–Ser324, Ile326–Asp295, and Cys328–Met294 are the key residue pairs of the dimer–dimer interfaces to maintain the dimer–dimer structures of MrNVPd through charge–charge, charge–dipole, dipole–dipole, hydrophobic, and hydrogen bonding interactions. The strengths of these intermolecular dimer–dimer interactions in the parallel conformation are much greater than those in the X-shaped conformation. The parallel trimeric interface is held basically by electrostatic and hydrophobic interactions. The electrostatic interactions accompanying a strong hydrogen bond of Oγ1–Hγ1···Oγ1 in the Thr276 A–Thr276 D pair maintain the intermolecular interface of two X-shaped MrNVPd dimers.

A noncrystallographic symmetry-constrained map obtained by direct density optimization is efficient and equivalent to a noncrystallographic symmetry-averaging map. Using the noncrystallographic symmetry-constrained map, the structure of a T = 1 Penaeus vannamei nodavirus shell-domain subviral particle was newly determined by including twinned data., Noncrystallographic symmetry (NCS) averaging following molecular-replacement phasing is generally the major technique used to solve a structure with several molecules in one asymmetric unit, such as a spherical icosahedral viral particle. As an alternative method to NCS averaging, a new approach to optimize or to refine the electron density directly under NCS constraints is proposed. This method has the same effect as the conventional NCS-averaging method but does not include the process of Fourier synthesis to generate the electron density from amplitudes and the corresponding phases. It has great merit for the solution of structures with limited data that are either twinned or incomplete at low resolution. This method was applied to the case of the T = 1 shell-domain subviral particle of Penaeus vannamei nodavirus with data affected by twinning using the REFMAC5 refinement software.

This comparative study of the constitutional jurisprudence of three East Asian jurisdictions investigates how the rulings of the Constitutional Court of Taiwan, the Constitutional Court of Korea and the Hong Kong Court of Final Appeal have converged. The unique political contexts of all three jurisdictions have led to strong courts using the structured proportionality doctrine and innovative constitutional remedies to address human rights issues. Hong Kong, Taiwan, and South Korea have the only courts in Asia that regularly use a structured four-stage Proportionality Analysis to invalidate laws, and routinely apply innovative constitutional remedies such as Suspension Orders and Remedial Interpretation to rectify constitutionally flawed legislation. This volume explores how judges in these areas are affected by politics within their different constitutional systems. The latest developments in Asian constitutional law are covered, with detailed analysis of key cases.

The protrusion-domain (P-domain) of Penaeus vannamei nodavirus (PvNV) exists as two dimer-dimer conformations: one is a protein dimer and the other is a protein tetramer. We undertook a theoretical study to gain a clear understanding of the nature of the stabilizing interactions at the dimeric interfaces of the dimeric and tetrameric conformations of the PvNV P-domain (PvNVPd) using the quantum theory of atoms in molecules (QTAIM) and natural-bond orbital (NBO) analyses in the framework of the density-functional theory (DFT) approach. The QTAIM analysis characterized the presence of multiple hydrogen bonds of common types with strength ranging from electrostatic to the covalent limit inside the PvNVPd dimer-dimer interfaces. Val257-Lys335, Phe294-Val330, Gln296-Thr328, Glu296-Thr329, Thr328-Gln297, Val330-Ala293, Lys335-Asp256 and Lys335-Val257 pairs are critical residue pairs of all three dimeric interfaces of PvNVPd. They preserve these dimeric interfaces through charge-charge, charge-dipole, dipole-dipole, hydrophobic and hydrogen bond interactions. The strongest intermolecular dimer–dimer interactions belong to the dimeric interface between subunits A and B of PvNVPd in the tetrameric conformation.

An efficient pattern recognition technology is applied to recognize the number character of lottery and invoice is proposed in this paper. There are some Arabic numerals of lottery or invoice tickets easy to be confused because of unclear printing. In this algorithm, an image processing and pattern recognition technology is applied. The advantage of this algorithm includes that the region of interest for images can be captured automatically and the accuracy of recognition is remarkable. In order to compare the Arabic numerals of invoice with template in database, the optical character recognition technology is proposed. According to compare the normalized character with template in database, the algorithm can recognize the correct Arabic numerals of lottery or invoice tickets. Based on experimental results, the proposed algorithm in this paper is efficient and has high accuracy.

Shrimp nodaviruses, including Penaeus vannamei (PvNV) and Macrobrachium rosenbergii nodaviruses (MrNV), cause white-tail disease in shrimps, with high mortality. The viral capsid structure determines viral assembly and host specificity during infections. Here, we show cryo-EM structures of T = 3 and T = 1 PvNV-like particles (PvNV-LPs), crystal structures of the protrusion-domains (P-domains) of PvNV and MrNV, and the crystal structure of the ∆N-ARM-PvNV shell-domain (S-domain) in T = 1 subviral particles. The capsid protein of PvNV reveals five domains: the P-domain with a new jelly-roll structure forming cuboid-like spikes; the jelly-roll S-domain with two calcium ions; the linker between the S- and P-domains exhibiting new cross and parallel conformations; the N-arm interacting with nucleotides organized along icosahedral two-fold axes; and a disordered region comprising the basic N-terminal arginine-rich motif (N-ARM) interacting with RNA. The N-ARM controls T = 3 and T = 1 assemblies. Increasing the N/C-termini flexibility leads to particle polymorphism. Linker flexibility may influence the dimeric-spike arrangement., Nai-Chi Chen et al. solved the structures of two shrimp nodaviruses, focusing on the major domains to improve understanding of capsid organization. By combining cryo-EM and x-ray crystallography, the authors were able to observe the structures at a high resolution.

Recent years have witnessed the reemergence of discussions on Confucian constitutionalism, communitarian constitutionalism, and Asian values. Despite the differences of these concepts, all reject Western liberal constitutionalism, emphasizing that Asian countries should prioritize social and economic rights over civil and political rights. Nevertheless, this dichotomy in fact does not hold in Taiwan and many other East Asian jurisdictions. This chapter suggests that, on the one hand, constitutionalism in East Asia is inevitably a blend of liberal constitutionalism and Confucian constitutionalism. Namely, in East Asia, the differences between democracies and dictatorships in this regard are often a matter of degree, not of kind. On the other hand, human rights are better protected in Taiwan than in most other Asian countries because the progress in human rights is taking place concomitantly with the decline of Confucianism. From this perspective, it is plausible that Taiwan will become the only democracy among societies that predominantly are comprised of people of Chinese descent precisely because it discards Confucianism and Asian values, which serve as a veneer of legitimacy for autocrats to justify dictatorship.

A two-step process of phase determination in the X-ray structural analysis of the coat protein of a betanodavirus is described. A new indicator, the free fraction, for molecular averaging in real space is introduced to effectively evaluate the phasing power in order to enhance the success of determining new structures., Molecular averaging, including noncrystallographic symmetry (NCS) averaging, is a powerful method for ab initio phase determination and phase improvement. Applications of the cross-crystal averaging (CCA) method have been shown to be effective for phase improvement after initial phasing by molecular replacement, isomorphous replacement, anomalous dispersion or combinations of these methods. Here, a two-step process for phase determination in the X-ray structural analysis of a new coat protein from a betanodavirus, Grouper nervous necrosis virus, is described in detail. The first step is ab initio structure determination of the T = 3 icosahedral virus-like particle using NCS averaging (NCSA). The second step involves structure determination of the protrusion domain of the viral molecule using cross-crystal averaging. In this method, molecular averaging and solvent flattening constrain the electron density in real space. To quantify these constraints, a new, simple and general indicator, free fraction (ff), is introduced, where ff is defined as the ratio of the volume of the electron density that is freely changed to the total volume of the crystal unit cell. This indicator is useful and effective to evaluate the strengths of both NCSA and CCA. Under the condition that a mask (envelope) covers the target molecule well, an ff value of less than 0.1, as a new rule of thumb, gives sufficient phasing power for the successful construction of new structures.

Based on plastically compressed cell-seeded collagen gels, we fabricated a small-diameter tubular construct that withstands arterial pressure without prolonged culture in vitro. Specifically, to mimic the microstructure of vascular media, the cell-seeded collagen gel was uniaxially stretched prior to plastic compression to align collagen fibers and hence cells in the gel. The resulting gel sheet was then wrapped around a custom-made multi-layered braided tube to form aligned tubular constructs whereas the gel sheet prepared similarly but without uniaxial stretching formed control constructs. With the braided tube, fluid in the gel construct was further removed by vacuum suction aiming to consolidate the concentric layers of the construct. The construct was finally treated with transglutaminase. Both SEM and histology confirmed the absence of gaps in the wall of the construct. Particularly, cells in the wall of the aligned tubular construct were circumferentially aligned. The enzyme-mediated crosslinking increased burst pressure of both the constructs significantly; the extent of the increase of burst pressure for the aligned tubular construct was greater than that for the control counterpart. Increasing crosslinking left the compliance of the aligned tubular construct unchanged but reduced that of the control construct. Cells remained viable in transglutaminase-treated plastically compressed gels after 6 days in culture. This study demonstrated that by combining stretch-induced fiber alignment, plastic compression, and enzyme-mediated crosslinking, a cell-seeded collagen gel-based tubular construct with potential to be used as vascular media can be made within 3 days.

This paper presents a 60-GHz CMOS direct-conversion Doppler radar RF sensor with a clutter canceller for single-antenna noncontact human vital-signs detection. A high isolation quasi-circulator (QC) is designed to reduce the transmitting (Tx) power leakage (to the receiver). The clutter canceller performs cancellation for the Tx leakage power (from the QC) and the stationary background reflection clutter to enhance the detection sensitivity of weak vital signals. The integration of the 60-GHz RF sensor consists of the voltage-controlled oscillator, divided-by-2 frequency divider, power amplifier, QC, clutter canceller (consisting of variable-gain amplifier and 360 $^{\circ}$ phase shifter), low-noise amplifier, in-phase/quadrature-phase sub-harmonic mixer, and three couplers. In the human vital-signs detection experimental measurement, at a distance of 75 cm, the detected heartbeat (1–1.3 Hz) and respiratory (0.35–0.45 Hz) signals can be clearly observed with a 60-GHz 17-dBi patch-array antenna. The RF sensor is fabricated in 90-nm CMOS technology with a chip size of ${\hbox{2 mm}}\times {\hbox{2 mm}}$ and a consuming power of 217 mW.

Constitutions and courts play important roles not only in democracies but also in dictatorships. Yet the functions of constitutions and courts actually differ from one autocracy to another. After the Chinese Civil War, China and pre-democratic Taiwan adopted different strategies to address political cataclysm, even though the Communist Party and the Nationalist Party shared many characteristics. China has repeatedly rewritten its constitutions to adapt to the ever-changing world, rendering the judiciary impotent. Taiwan, on the other hand, maintained judicial review even during the authoritarian period, while leaving its Constitution frozen. The disparity, this article suggests, should be attributed to the different functions of constitutions and courts in the two Chinese authoritarian societies. Taiwan needed to rely on its Constitution and constitutional court to formally justify its claim as the sole legitimate Chinese government. In contrast, China uses its living constitutions to transmit messages to the world about its latest political, social, and economic developments.

Guan, H., Hsieh, Y., Lin, P. et al. Structural insights into the electron/proton transfer pathways in the quinol : fumarate reductase from Desulfovibrio gigas. Sci Rep 8, 14935 (2018) doi:10.1038/s41598-018-33193-5, The membrane-embedded quinol: fumarate reductase (QFR) in anaerobic bacteria catalyzes the reduction of fumarate to succinate by quinol in the anaerobic respiratory chain. The electron/protontransfer pathways in QFRs remain controversial. Here we report the crystal structure of QFR from the anaerobic sulphate-reducing bacterium Desulfovibrio gigas (D. gigas) at 3.6 Å resolution. The structure of the D. gigas QFR is a homo-dimer, each protomer comprising two hydrophilic subunits, A and B, and one transmembrane subunit C, together with six redox cofactors including two b-hemes. One menaquinone molecule is bound near heme bL in the hydrophobic subunit C. This location of the menaquinone-binding site differs from the menaquinol-binding cavity proposed previously for QFR from Wolinella succinogenes. The observed bound menaquinone might serve as an additional redox cofactor to mediate the proton-coupled electron transport across the membrane. Armed with these structuralinsights, we propose electron/proton-transfer pathways in the quinol reduction of fumarate to succinate in the D. gigas QFR.

Many fear that constitutional democracy is under threat from democratic backlash and losing ground to illiberal constitutionalism. Discussion of this supposedly global trend, however, often takes relatively little account of East Asia, if not Asia more generally, which is deeply problematic given both the intrinsic importance and the heterogeneity of the region. This essay draws on Asian experience over the last three decades to evaluate three hypotheses that might explain the prevalence and stability of constitutional democracy: (1) the contagion hypothesis, (2) the constitutional inertia hypothesis, and (3) the regime performance hypothesis. Comparison of such jurisdictions as South Korea, Taiwan, Singapore, Hong Kong, China, and Thailand is sufficient to cast doubt on (1) but suggests that (2) and (3) are both plausible. On the whole, this vast region is characterized more by regime stability than either backsliding or hegemony of any particular regime type. What the future appears to hold for Asia is more of the same—namely, regime pluralism.

This study argues that the structure of bid-ask spreads is asymmetric across the business cycle. During expansion, investors tend to be overconfident, leading to a higher spread component due to information asymmetry. On the other hand, during recession, the markets are more volatile, leading to a higher spread component due to order processing costs. With TAIEX futures contracts as a sample, it is found that the spread component due to information asymmetry is significantly higher in times of expansion than in times of recession, while the spread component due to order processing cost is significantly higher in times of recession than in times of expansion.

This study proposed a triple-passband bandpass filter with compact size, low loss and high passband selectivity. The filter includes two coupled stepped impedance resonators (SIRs) and two embedded stub-loaded stepped impedance resonators (SL-SIRs), connected with coupling scheme at the symmetric plane of the filter. The filter is designed to have triple-passband at 2.4, 3.5 and 5.2GHz for worldwide interoperability for microwave access (WiMAX) applications. By properly tuning the impedance ratio and physical length ratio of the SL-SIRs, the three passbands can be easily determined, at the same time, achieving the high passband selectivity and wide stopband. Besides, the transmission zeros near passband edges of each passband are generated by the proposed filter with cross-coupling structure. The measured results are in good agreement with the full-wave electromagnetic (EM) simulation results.

In this study, I investigate lead-lag relationships among Asia-Pacific country stock returns. Taking the GARCH effects into account, I estimate a prediction model, and find that lagged Singapore returns exhibit the strongest predictive ability for the returns of Asia-Pacific countries. Estimating this model, I find that lagged Singapore returns exhibit the strongest predictive ability for the returns of Asia-Pacific countries. The Asia-Pacific stock markets react with a delay of information contained in lagged Singapore returns about their fundamentals, and that information diffuses gradually across Asia-Pacific stock markets. Finally, using the MSPE-adjusted statistic, I provide out-of-sample evidence to examine the consistency of the predictive power of lagged Singapore returns.