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This mini-special issue of the IEEE Transactions on Microwave Theory and Techniques includes seven expanded articles from the sixth IEEE MTT-S International Wireless Symposium (IEEE IWS 2019) held on May 19–22, 2019, in Guangzhou, China. [ABSTRACT FROM AUTHOR]

Over the past few years a significant growth of research involving the utilization of RF/microwave technologies in healthcare applications has been taking place. This "Special Issue on Biomedical Applications of RF/Microwave Technologies" is proof. Encouraged by funding from government agencies and private sources, and recognizing the emerging opportunities offered by high-frequency electronics and novel sensing technologies for advancing healthcare, researchers from various engineering disciplines have directed their interests to applications involving biological science and clinical medicine. The increase in RF/microwave-related activities targeting medical or biological problems is noticeable within the IEEE Microwave Theory and Techniques Society (IEEE MTT-S) community and beyond. These activities are broad in their scopes and involve multiple disciplines. They range from therapeutic, diagnostic, remote monitoring, and imaging applications of microwave technologies in clinical settings, as well as those involving sensing and communication over or through body tissues, where physiological or biochemical information are transmitted wirelessly, to the biological effects of these applications, in which the interaction of microwaves with tissues and living systems should be understood and manipulated. In addition, RF/microwave now serves as one of the key enabling technologies in innovative healthcare delivery and telemedicine. Three papers are on exposure systems for bioelectromagnetic research. Nine papers present radar-based systems for vital sign monitoring and object imaging. The remaining two radar papers focus on cancer detection by imaging. The Special Issue features papers from the US, UK, Japan, Korea, Australia, Canada, Saudi Arabia, Italy, Malaysia, Belgium, Germany, China, and France, indicating global efforts utilizing RF/microwave innovation for healthcare. [ABSTRACT FROM AUTHOR]

The nine papers in this special section were presented at the 2013 IMWS-Bio Conference that was held in Singapore, December 9?11, 2013. [ABSTRACT FROM AUTHOR]

A resonator coupler for subcutaneous implants has been developed with a new impedance matching pattern added to the conventional loop antenna. The tuning element of a concentric metal pad contributes distributed capacitance and inductance to the planar inductive loop and improves resonance significantly. It provides a better qualify factor for resonant coupling and a much lower reflection coefficient for the implant electronics. Practical constraints are taken into account for designs including the requirement of operation within a regulated frequency band and the limited thickness for a monolithic implant. In this work, two designs targeting to operate in the two industrial, scientific, and medical (ISM) bands at 903 MHz and 2.45 GHz are considered. The tuning metal pad improves their resonances significantly, compared to the conventional loop designs. Since it is difficult to tune the implant antenna after implantation, the effects of tissue depth variations due to the individual's surgery and the appropriate implant depths are investigated. Simulations conducted with the dielectric properties of human skin documented in the literature are compared to measurements done with hydrated ground pork as phantoms. Experiments and simulations are conducted to explain the discrepancies in frequency shifts due to the uses of pork phantoms. The design method is thus validated for uses on human skin. A noninvasive localization method to identify the implant under the skin has been examined and demonstrated by both simulations and measurements. It can efficiently locate the subcutaneous implant based on the high quality-factor resonance owing to the tuning elements in both implant and transmitter couplers. The planar resonant coupler for wireless power transfer shows good performance and promise in subcutaneous applications for implants. [ABSTRACT FROM AUTHOR]

Intraoperative neurophysiological monitoring (IONM) is utilized to minimize neurological morbidity during spine surgery. Transcranial motor evoked potentials (TcMEPs) are principal IONM signals in which the motor cortex of the subject is stimulated with electrical pulses and the evoked potentials are recorded from the muscles of interest. Currently available monitoring systems require the connection of 40–60 lengthy lead wires to the patient. These wires contribute to a crowded and cluttered surgical environment, and limit the maneuverability of the surgical team. In this work, it was demonstrated that the cumbersome wired system is vulnerable to electromagnetic interference (EMI) produced by operating room (OR) equipment. It was hypothesized that eliminating the lengthy recording wires can remove the EMI induced in the IONM signals. Hence, a wireless system to acquire TcMEPs was developed and validated through bench-top and animal experiments. Side-by-side TcMEPs acquisition from the wired and wireless systems in animal experiments under controlled conditions (absence of EMI from OR equipment) showed comparable magnitudes and waveforms, thus demonstrating the fidelity in the signal acquisition of the wireless solution. The robustness of the wireless system to minimize EMI was compared with a wired-system under identical conditions. Unlike the wired-system, the wireless system was not influenced by the electromagnetic waves from the C-Arm X-ray machine and temperature management system in the OR. [ABSTRACT FROM AUTHOR]

In this paper, we report a power management system for autonomous and real-time monitoring of the neurotransmitter L-glutamate (L-Glu). A low-power, low-noise, and high-gain recording module was designed to acquire signal from an implantable flexible L-Glu sensor fabricated by micro-electro-mechanical system (MEMS)-based processes. The wearable recording module was wirelessly powered through inductive coupling transmitter antennas. Lateral and angular misalignments of the receiver antennas were resolved by using a multi-transmitter antenna configuration. The effective coverage, over which the recording module functioned properly, was improved with the use of in-phase transmitter antennas. Experimental results showed that the recording system was capable of operating continuously at distances of 4 cm, 7 cm and 10 cm. The wireless power management system reduced the weight of the recording module, eliminated human intervention and enabled animal experimentation for extended durations. [ABSTRACT FROM AUTHOR]

This paper presents design and optimization methods for spiral coils utilized for wireless power transfer in wireless medical implant applications. A theoretical model was examined for near-field distributions of spiral-type transmitter antennas in both orthogonal components. Finite-element simulations were performed to verify the theoretical radiation patterns. Receiver antenna voltages were measured at planes of interest as a means to map field distributions. Theoretical, simulation, and experimental results were conducted in free space and they agreed well. Understanding the orthogonal field components and their distributions in various distances between the worn transmitter coil outside the body and the receiver coil of implant that has a much smaller size provides a means to find the optimal location and angle to harvest maximum energy. The analysis method for near-field wireless power transmission can be utilized to determine design strategies of the transmitter spiral coil with considerations also in the amplifier circuit and physical constraints in practical scenarios to obtain maximum power and link efficiency for the implant devices. The method can be extended to investigate field distributions affected by human tissues, which construct a much more complex environment, and will be conducted in future works. [ABSTRACT FROM AUTHOR]

In this letter, we developed an integrated neural probe prototype for optogenetic stimulation by microscale light-emitting diode (μLED) and simultaneous recording of neural activities with microelectrodes on a single-polyimide platform. Optogenetics stimulates in vivo neural circuits with high-cellular specificity achieved by genetic targeting and precise temporal resolution by interaction of light-gated ion channels with optical beam. In our newly developed optrode probe, during optogenetic stimulation of neurons, continuous sensing of neuronal activities in vicinity of the activation site can provide feedback to stimulation or examine local responses in signal pathways. In the device, focusing the light from the μLED was achieved with an integrated photo-polymerized lens. The efficacy of the optrode for cortical stimulation and recording was tested on mice visual cortex neurons expressing channelrhodopsin-2. Stimulation intensity and frequency-dependent spiking activities of visual cortex were recorded. Our device has shown advantages over fiber-coupled laser-based optrode in terms of closed-loop integration, single-implant compactness and lower electrical power requirements, which would be clinically applicable for future prosthetic applications in personalized medicine. [ABSTRACT FROM PUBLISHER]

In this study, a device for gastroesophageal reflux disease (GERD) monitoring has been prototyped. The system consists of an implantable, batteryless and wireless transponder with integrated impedance and pH sensors; and a wearable, external reader that wirelessly powers up the transponder and interprets the transponded radio-frequency signals. The transponder implant with the total size of 0.4 cm ×0.8 cm ×3.8 cm harvests radio frequency energy to operate dual-sensor and load-modulation circuitry. The external reader can store the data in a memory card and/or send it to a base station wirelessly, which is optional in the case of multiple-patient monitoring in a hospital or conducting large-scale freely behaving animal experiments. Tests were carried out to verify the signal transduction reliability in different situations for antenna locations and orientation. In vitro, experiments were conducted in a mannequin model by positioning the sensor capsule inside the wall of a tube mimicking the esophagus. Different liquids with known pH values were flushed through the tube creating reflux episodes and wireless signals were recorded. Live pigs under anesthesia were used for the animal models with the transponder implant attached on the esophageal wall. The reflux episodes were created while the sensor data were recorded wirelessly. The data were compared with those recorded independently by a clinically used wireless pH sensor capsule placed next to our implant transponder. The results showed that our transponder detected every episode in both acid and nonacid nature, while the commercial pH sensor missed events that had similar, repeated pH values, and failed to detect pH values higher than 10. Our batteryless transponder does not require a battery thus allowing longer diagnosis and prognosis periods to monitor drug efficacy, as well as providing accurate assessment of GERD symptoms. [ABSTRACT FROM PUBLISHER]

Optical fibers coated with various non-magnetized ferromagnetic materials and actuated by external magnetic fields were designed and characterized to demonstrate the feasibility for remote scanning. Cobalt, iron, nickel, and samarium-cobalt powders were used to enable the actuation. Silica optical fibers were coated with a mixture of 70% enamel paint and 30% various ferromagnetic materials. The static and dynamic measurements were preformed under the remote control of an electromagnet. Experiments with different ferromagnetic materials and different suspended fiber lengths of 3.2 cm, 4.2 cm, 5.2 cm, 6.2 cm, and 7.2 cm were performed to compare with theory. The static displacements, dynamic displacements and resonant frequencies of the actuation were measured. [ABSTRACT FROM AUTHOR]

Abstract: Distributed MEMS phase shifters using CMOS-grade low-resistivity silicon have been successfully developed. Kapton films were utilized as dielectric layers to reduce RF signal attenuation in the lossy silicon substrate. The scattering parameters were evaluated from DC to 26GHz. The phase shifting reaches 43° and insertion losses are less than 1.4dB. The manufacturing process is simple and compatible with CMOS and post CMOS processes. [Copyright &y& Elsevier]

Abstract: Clinical studies have shown that spinal or cortical neurostimulation could significantly improve pain relief. The currently available stimulators, however, are used only to generate specific electrical signals without the knowledge of physiologically responses caused from the stimulation. We thus propose a new system that can adaptively generate the optimized stimulating signals base on the correlated neuron activities. This new method could significantly improve the efficiency of neurostimulation for pain relief. We have developed an integrated wireless recording and stimulating system to transmit the neuronal signals and to activate the stimulator over the wireless link. A wearable prototype has been developed consisting of amplifiers, wireless modules and a microcontroller remotely controlled by a Labview program in a computer to generate desired stimulating pulses. The components were assembled on a board with a size of 2.5cm×5cm to be carried by a rat. To validate our system, lumbar spinal cord dorsal horn neuron activities of anesthetized rats have been recorded in responses to various types of peripheral graded mechanical stimuli. The stimulation at the periaqueductal gray and anterior cingulate cortex with different combinations of electrical parameters showed a comparable inhibition of spinal cord dorsal horns activities in response to the mechanical stimuli. The Labview program was also used to monitor the neuronal activities and automatically activate the stimulator with designated pulses. Our wireless system has provided an opportunity for further study of pain processing with closed-loop stimulation paradigm in a potential new pain relief method. [Copyright &y& Elsevier]

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical user interface. The front-end module conditions the analogue signals, then digitizes and loads the data into a radio for transmission. Data receipt at the back-end is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35 × 35 × 27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124 h operation when utilizing a 560 mAh, 3 V battery. In vivo, slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles min−1), automated activation time detection was modestly better for the wireless system (5% versus 14% FP rate), and signal amplitudes were modestly higher via the wireless system (462 versus 386 µV; p < 0.001). This telemetric system for slow wave acquisition is reliable, power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients. [ABSTRACT FROM AUTHOR]