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786 results on '"Chiang, Alan"'

4. A Comprehensive Toolbox to Facilitate Quantitative Decision Science in Drug Development: A web-based R shiny application GOahead

Author

Wei, Bo, Zhong, Weibin, Liu, Rong, Wu, Alan, Chiang, Alan, Branson, Michael, and Ge, Nanxiang

Subjects
Statistics - Applications
Abstract

Decision-making is critical at each stage of drug development and making informed and transparent Go/No-Go decisions require a sound quantitative decision framework. We designed and implemented GOahead, a comprehensive web-based tool to improve how statisticians and collaborators could prospectively plan and implement the selected Go/No-Go decision approach in real-time. In the paper, we conducted a comprehensive overview of dual-criterion and confidence interval-based approaches to enable quantitative decision-making. illustrative examples are demonstrated for single and two arms designs in both Bayesian and frequentist frameworks, multiple arms design with MCP-MOD is also demonstrated. GOahead can be found on shinyapps server.

Published
2022

5. An Empirical Bayes Robust Meta-Analytical-Predictive Prior to Adaptively Leverage External Data

Author

Zhang, Hongtao, Shen, Yueqi, Chiang, Alan Y, and Li, Judy

Subjects
Statistics - Methodology
Abstract

We propose a novel empirical Bayes robust MAP (EB-rMAP) prior to adaptively leverage external/historical data. Built on Box's prior predictive p-value, the EB-rMAP prior framework balances between model parsimony and flexibility through a tuning parameter. The proposed framework can be applied to binary, normal, and time-to-event endpoints. Computational aspects of the framework are efficient. Simulations results with different endpoints demonstrate that the EB-rMAP prior is robust in the presence of prior-data conflict while preserving statistical power. The proposed EB-rMAP prior is then applied to a clinical dataset that comprises of ten oncology clinical trials, including the perspective study.

Published
2021

6. Improving the Performance of Bayesian Logistic Regression Model with Overdose Control in Oncology Dose-Finding Studies

Author

Zhang, Hongtao, Chiang, Alan Y, and Wang, Jixian

Subjects
Statistics - Methodology
Abstract

An accurately identified maximum tolerated dose (MTD) serves as the cornerstone of successful subsequent phases in oncology drug development. Bayesian logistic regression model (BLRM) is a popular and versatile model-based dose-finding design. However, BLRM with original overdose control strategy has been reported to be safe but "excessively conservative". In this manuscript, we investigate the reason for conservativeness and point out that a major reason could be the lack of appropriate underdose control. We propose designs that balance overdose and underdose control to improve the performance over original BLRM. Simulation results reveal that the new designs have better accuracy and treat more patients at MTD.

Published
2021

7. Effect of rituximab on immune status in children with mature B-cell non-Hodgkin lymphoma: a prespecified secondary analysis of the Inter-B-NHL Ritux 2010 trial

Author

Alexander, Sarah, Aupérin, Anne, Bomken, Simon, Csóka, Monika, Kazanowska, Bernarda, Chiang, Alan K, Andres, Mara, Uyttebroeck, Anne, Burke, G A Amos, Zsiros, József, Pillon, Marta, Bollard, Catherine M, Mussolin, Lara, Verdu-Amoros, Jaime, Neven, Bénédicte, Barkauskas, Donald A, Wheatley, Keith, Patte, Catherine, Gross, Thomas G, and Minard-Colin, Véronique

Published
2023
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8. Improving outcomes of childhood and young adult non-Hodgkin lymphoma: 25 years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma

Author

Beishuizen, Auke, Mellgren, Karin, Andrés, Mara, Auperin, Anne, Bacon, Chris M, Bomken, Simon, Burke, G A Amos, Burkhardt, Birgit, Brugieres, Laurence, Chiang, Alan K S, Damm-Welk, Christine, d'Amore, Emanuele, Horibe, Keizo, Kabickova, Edita, Khanam, Tasneem, Kontny, Udo, Klapper, Wolfram, Lamant, Laurence, Le Deley, Marie-Cecile, Loeffen, Jan, Macintyre, Elizabeth, Mann, Georg, Meyer-Wentrup, Friederike, Michgehl, Ulf, Minard-Colin, Veronique, Mussolin, Lara, Oschlies, Ilske, Patte, Catherine, Pillon, Marta, Reiter, Alfred, Rigaud, Charlotte, Ronceray, Leila, Salaverria, Itziar, Simonitsch-Klupp, Ingrid, Uyttebroeck, Anne, Verdu-Amoros, Jaime, Williams, Denise, Woessmann, Wilhelm, Wotherspoon, Andrew, Wrobel, Grazyna, Zimmermann, Martin, Attarbaschi, Andishe, and Turner, Suzanne D

Published
2023
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12. Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma.

Author

Lin, Weitao, Yip, Yim Ling, Jia, Lin, Deng, Wen, Zheng, Hong, Dai, Wei, Ko, Josephine Mun Yee, Lo, Kwok Wai, Chung, Grace Tin Yun, Yip, Kevin Y, Lee, Sau-Dan, Kwan, Johnny Sheung-Him, Zhang, Jun, Liu, Tengfei, Chan, Jimmy Yu-Wai, Kwong, Dora Lai-Wan, Lee, Victor Ho-Fun, Nicholls, John Malcolm, Busson, Pierre, Liu, Xuefeng, Chiang, Alan Kwok Shing, Hui, Kwai Fung, Kwok, Hin, Cheung, Siu Tim, Cheung, Yuk Chun, Chan, Chi Keung, Li, Bin, Cheung, Annie Lai-Man, Hau, Pok Man, Zhou, Yuan, Tsang, Chi Man, Middeldorp, Jaap, Chen, Honglin, Lung, Maria Li, and Tsao, Sai Wah

Subjects
Cell Line, Tumor, Animals, Mice, Inbred NOD, Humans, Mice, SCID, Herpesvirus 4, Human, Virion, Protein Kinase Inhibitors, Xenograft Model Antitumor Assays, Phylogeny, Virus Activation, Mutation, Genes, Viral, Adult, Aged, Middle Aged, Female, Male, rho-Associated Kinases, Nasopharyngeal Carcinoma, Cell Line, Tumor, Genes, Viral, Herpesvirus 4, Human, Mice, Inbred NOD, SCID
Abstract

The lack of representative nasopharyngeal carcinoma (NPC) models has seriously hampered research on EBV carcinogenesis and preclinical studies in NPC. Here we report the successful growth of five NPC patient-derived xenografts (PDXs) from fifty-eight attempts of transplantation of NPC specimens into NOD/SCID mice. The take rates for primary and recurrent NPC are 4.9% and 17.6%, respectively. Successful establishment of a new EBV-positive NPC cell line, NPC43, is achieved directly from patient NPC tissues by including Rho-associated coiled-coil containing kinases inhibitor (Y-27632) in culture medium. Spontaneous lytic reactivation of EBV can be observed in NPC43 upon withdrawal of Y-27632. Whole-exome sequencing (WES) reveals a close similarity in mutational profiles of these NPC PDXs with their corresponding patient NPC. Whole-genome sequencing (WGS) further delineates the genomic landscape and sequences of EBV genomes in these newly established NPC models, which supports their potential use in future studies of NPC.

Published
2018

18. Combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in spontaneous lymphoblastoid cell lines.

Author

Tam, Kam Pui, Xie, Jia, Au-Yeung, Rex Kwok Him, and Chiang, Alan K. S.

Subjects
LYMPHOBLASTOID cell lines, DNA repair, PROTEASOME inhibitors, POISONS, VENETOCLAX
Abstract

Epstein-Barr virus (EBV) manipulates the ubiquitin-proteasome system and regulators of Bcl-2 family to enable the persistence of the virus and survival of the host cells through the expression of viral proteins in distinct latency patterns. We postulate that the combination of bortezomib (proteasome inhibitor) and venetoclax (Bcl-2 inhibitor) [bort/venetoclax] will cause synergistic killing of post-transplant lymphoproliferative disorder (PTLD) through targeting the pro-survival function of latent viral proteins such as latent membrane protein-1 (LMP-1) and EBV nuclear antigen-3C (EBNA-3C). Bort/venetoclax could synergistically kill spontaneous lymphoblastoid cell lines (sLCLs) derived from patients with PTLD and EBV-associated hemophagocytic lymphohistiocytosis by inducing DNA damage response, apoptosis and G1-S cell cycle arrest in a ROS-dependent manner. Bortezomib potently induced the expression of Noxa, a pro-apoptotic initiator and when combined with venetoclax, inhibited Mcl-1 and Bcl-2 simultaneously. Bortezomib prevented LMP-1 induced proteasomal degradation of IκBα leading to the suppression of the NF-κB signaling pathway. Bortezomib also rescued Bcl-6 from EBNA-3C mediated proteasomal degradation thus maintaining the repression of cyclin D1 and Bcl-2 causing G1-S arrest and apoptosis. Concurrently, venetoclax inhibited Bcl-2 upregulated by either LMP-1 or EBNA-3C. Bort/venetoclax decreased the expression of phosphorylated p65 and Bcl-2 at serine 70 thereby suppressing the NF-κB signaling pathway and promoting apoptosis, respectively. These data corroborated the marked suppression of the growth of xenograft of sLCL in SCID mice (p<0.001). Taken together, the combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in spontaneous lymphoblastoid cell lines. Author summary: Epstein-Barr virus (EBV) is an oncogenic virus associated with different cancers and can directly drive the development of a lymphoma type condition in organ transplant patients known as post-transplant lymphoproliferative disorder (PTLD) as a result of weakened immune surveillance of EBV. The malignant spectrum of PTLD will require multi-agent chemotherapy regimen which is not well tolerated by the immunocompromised patients. Here, we combined bortezomib (proteasome inhibitor) with venetoclax (Bcl-2 inhibitor) as a novel strategy to target the pro-survival function of key EBV onco-proteins, namely LMP-1 and EBNA-3C. We demonstrated that this chemotherapy-free regimen could be highly effective in killing patient-derived spontaneous lymphoblastoid cell lines which represent cell models of PTLD. The novel drug regimen can avoid the toxic effects of chemotherapy and may have high efficacy and specificity for the treatment of PTLD. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Supplementary Table 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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20. Supplementary Figure 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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21. Supplementary Methods from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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22. Supplementary Figure 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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23. Supplementary Figure 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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24. Supplementary Figure 4 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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25. Supplementary Table 7 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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26. Supplementary Table 6 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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27. Supplementary Table 8 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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28. Supplementary Table 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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29. Supplementary Table 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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30. Supplementary Figure 3 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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31. Supplementary Figure 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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32. Supplementary Table 5 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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33. TABLE 1 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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34. Supplementary Table 9 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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35. Supplementary Table 2 from Establishment and Characterization of an Epstein-Barr Virus–positive Cell Line from a Non-keratinizing Differentiated Primary Nasopharyngeal Carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, primary, Lee, Hui Mei, primary, Abdul Aziz, Norazlin, primary, Yee, Pei San, primary, Marzuki, Marini, primary, Wong, Ka Wo, primary, Chiang, Alan K.S., primary, Chow, Larry Ka-Yue, primary, Dai, Wei, primary, Liu, Teng Fei, primary, Tan, Lu Ping, primary, Khoo, Alan Soo Beng, primary, Lo, Kwok Wai, primary, Lim, Paul V.H., primary, Rajadurai, Pathmanathan, primary, Lightfoot, Howard, primary, Barthorpe, Syd, primary, Garnett, Mathew J., primary, and Cheong, Sok Ching, primary

Published
2024
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36. Establishment and characterization of an Epstein-Barr virus-positive cell line from a non-keratinizing differentiated primary nasopharyngeal carcinoma

Author

Chai, Annie Wai Yeeng, primary, Yee, Shi Mun, additional, Lee, Hui Mei, additional, Abdul Aziz, Norazlin, additional, Yee, Pei San, additional, Marzuki, Marini, additional, Wong, Ka Wo, additional, Chiang, Alan K.S., additional, Chow, Larry Ka-Yue, additional, Dai, Wei, additional, Liu, Teng Fei, additional, Tan, Lu Ping, additional, Khoo, Alan Soo Beng, additional, Lo, Kwok Wai, additional, Lim, Paul VH, additional, Rajadurai, Pathmanathan, additional, Lightfoot, Howard, additional, Barthorpe, Syd, additional, Garnett, Mathew J, additional, and Cheong, Sok Ching, additional

Published
2024
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37. Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn 2+ -chelating function

Author

Jiang, Lijun, Lung, Hong Lok, Huang, Tao, Lan, Rongfeng, Zha, Shuai, Chan, Lai Sheung, Thor, Waygen, Tsoi, Tik-Hung, Chau, Ho-Fai, Boreström, Cecilia, Cobb, Steven L., Tsao, Sai Wah, Bian, Zhao-Xiang, Law, Ga-Lai, Wong, Wing-Tak, Tai, William Chi-Shing, Chau, Wai Yin, Du, Yujun, Tang, Lucas Hao Xi, Chiang, Alan Kwok Shing, Middeldorp, Jaap M., Lo, Kwok-Wai, Mak, Nai Ki, Long, Nicholas J., and Wong, Ka-Leung

Published
2019

38. HLA alleles associated with asparaginase hypersensitivity in Chinese children

Author

Chua, Gilbert T., Rosa Duque, Jaime S., Cheuk, Daniel Ka Leung, Leung, Alex Wing Kwan, Wong, Wilfred Hing Sang, Liu, Anthony Pak Yin, Lee, Pamela P. W., Ha, Shau Yin, Chiang, Alan Kwok Shing, Ho, Marco Hok Kung, Chu, Wai Keung, Chan, Yuk Sing, Luk, Chun Wing, Ling, Alvin Siu Cheung, Kwan, Mike Yat Wah, Yiu, Oscar Kuen Fong, Wong, Ian Chi Kei, Lau, Yu Lung, Li, Chi Kong, Leung, Wing Hang, Chan, Godfrey Chi Fung, Ip, Patrick, and Kwok, Janette

Published
2021
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39. Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents

Author

Attarbaschi, Andishe, Abla, Oussama, Ronceray, Leila, Bansil, Shweta, Bomken, Simon, Burkhardt, Birgit, Ceppi, Francecso, Chiang, Alan K.S., Dave, Hema, Fedorova, Alina, Henry, Michael, Jazbec, Janez, Kabickova, Edita, Kotecha, Rishi S., Lazic, Jelena, Loeffen, Jan, Miakova, Natalia, Osumi, Tomoo, Pillon, Marta, Pourtsidis, Apostolos, Rigaud, Charlotte, Tamamyan, Gevorg, Tandon, Sneha, Uyttebroeck, Anne, Verdu-Amoros, Jamie, Woessmann, Wilhelm, Wrobel, Grazyna, and Giulino-Roth, Lisa

Published
2019
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41. Large B-cell lymphoma-IRF4+ in children and young people: time to reduce chemotherapy in a rare malignant mature B-cell neoplasm?

Author

Huibers, Minke Henrina Willemina, primary, Abla, Oussama, additional, Andres, Mara, additional, Balagué, Olga, additional, Beishuizen, Auke, additional, Carraro, Elisa, additional, Chiang, Alan Kwok Shing, additional, Csoka, Monika, additional, David, Bianca-Andreea, additional, de Ville de Goyet, Maelle, additional, Gilad, Gil, additional, Hori, Daiki, additional, Kotecha, Rishi Sury, additional, Kabickova, Edita, additional, Klapper, Wolfram, additional, Miakova, Natalia, additional, Minard-Colin, Véronique, additional, Nakazawa, Atsuko, additional, Pillon, Marta, additional, Rigaud, Charlotte, additional, Salaverria, Itziar, additional, Tölle, Ida, additional, Verdu-Amorós, Jaime, additional, von Mersi, Hannah, additional, Woessmann, Wilhelm, additional, Burkhardt, Birgit, additional, and Attarbaschi, A, additional

Published
2024
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