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2. Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting.

Author

Cardon, Anaïs, Guinebretière, Thomas, Dong, Chuang, Gil, Laurine, Ado, Sakina, Gavlovsky, Pierre-jean, Braud, Martin, Danger, Richard, Schultheiß, Christoph, Doméné, Aurélie, Paul-Gilloteaux, Perrine, Chevalier, Caroline, Bernier, Laura, Judor, Jean-Paul, Fourgeux, Cynthia, Imbert, Astrid, Khaldi, Marion, Bardou-Jacquet, Edouard, Elkrief, Laure, and Lannes, Adrien

Abstract

Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against liver self-antigens, but how these autoreactive T cells relate to liver tissue pathology remains unclear. Here we perform single-cell transcriptomic and T cell receptor analyses of circulating, self-antigen-specific CD4 T cells from patients with AILD and identify a subset of liver-autoreactive CD4 T cells with a distinct B-helper transcriptional profile characterized by PD-1, TIGIT and HLA-DR expression. These cells share clonal relationships with expanded intrahepatic T cells and exhibit transcriptional signatures overlapping with tissue-resident T cells in chronically inflamed environments. Using a mouse model, we demonstrate that, following antigen recognition in the liver, CD4 T cells acquire an exhausted phenotype, play a crucial role in liver damage, and are controlled by immune checkpoint pathways. Our findings thus suggest that circulating autoreactive CD4 T cells in AILD are imprinted by chronic antigen exposure to promote liver inflammation, thereby serving as a potential target for developing biomarkers and therapies for AILD. Dysregulated CD4 T cells have been implicated in autoimmune liver disease, but their phenotypes and origin are still unclear. Here the authors profile circulating, autoreactive CD4 T cells to find transcription signatures similar to tissue-activated, exhausted T cells, thereby hinting a tissue origin for these circulation CD4 T cells. [ABSTRACT FROM AUTHOR]

Published
2025
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3. Early hepatocellular carcinoma detection using magnetic resonance imaging is cost-effective in high-risk patients with cirrhosis

Author

Nahon, Pierre, Asselah, Tarik, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Pageaux, Georges-Philippe, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Decaensi, Thomas, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Chazouillères, Olivier, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, d’Alteroche, Louis, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Cheraud-Carpentier, Marjorie, Hubert, Isabelle, Benhida, Jaouad, Lannes, Adrien, Lunel, Françoise, Oberti, Frédéric, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Wilson, Amy, Shili, Sarah, Chermak, Faiza, Ansaldi, Christelle, Ben Amara, Nisserine, Chouquet, Laëtitia, De Luca, Emilie, Oules, Valérie, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, De Dieuleveult, Barbara, Labarriere, Damien, Poter, Pascal, Si Ahmed, Si Nafa, Grando-Lemaire, Véronique, Bourcier, Valérie, Brulé, Séverine, Stalhberger, Thomas, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F., Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphanie, Ripault, Marie Pierre, Bureau, Christophe, Peron, Jean Marie, Robic, Marie Angèle, Tarallo, Léa, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, Montialoux, Hélène, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldine, Muti, Léon, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièle, Saillard, Eric, Lafrance, Marie-Josée, Cacoub, Patrice, Carrat, Fabrice, Carrieri, Patrizia, Delarocque-Astagneau, Elisabeth, De Ledinghen, Victor, Dorival, Céline, Dubuisson, Jean, Housset, Chantal, Larrey, Dominique, Marcellin, Patrick, Pawlotsky, Jean-Michel, Petrov-Sanchez, Ventzislava, Vaux, Sophie, Wittkop, Linda, Yazdanpanah, Yazdan, Zucman-Rossi, Jessica, Ganne-Carrié, Nathalie, Chaffaut, Cendrine, Moreno, Christophe, Moirand, Romain, Carbonell, Nicolas, Duclos-Vallée, Jean-Charles, de Ledinghen, Victor, Ozenne, Violaine, Henrion, Jean, Perlemuter, Gabriel, Amiot, Xavier, Chevret, Sylvie, Najean, Marie, Layese, Richard, Zarca, Kevin, Segar, Laeticia Blampain, Cagnot, Carole, N’Kontchou, Gisèle, Ronot, Maxime, Audureau, Etienne, and Durand-Zaleski, Isabelle

Published
2022
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4. Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort

Author

Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Cheraud-Carpentier, Marjorie, Hubert, Isabelle, Benhida, Jaouad, Lannes, Adrien, Lunel, Françoise, Oberti, Frédéric, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Wilson, Amy, Shili, Sarah, Chermak, Faiza, Ansaldi, Christelle, Amara, Nisserine Ben, Chouquet, Laëtitia, De Luca, Emilie, Oules, Valérie, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, De Dieuleveult, Barbara, Labarriere, Damien, Poter, Pascal, Ahmed, Si Nafa Si, Grando-Lemaire, Véronique, Nahon, Pierre, Bourcier, Valérie, Brulé, Séverine, Stalhberger, Thomas, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F., Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Pageaux, Georges-Philippe, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphanie, Ripault, Marie-Pierre, Bureau, Christophe, Peron, Jean Marie, Robic, Marie-Angèle, Tarallo, Léa, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, Montialoux, Hélène, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Vallée, Jean-Charles Duclos, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldine, Muti, Léon, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièle, Saillard, Eric, Lafrance, Marie-Josée, Vallet-Pichard, Anais, Correas, Jean-Michel, Dorival, Celine, Zoulim, Fabien, Tran, Albert, Bourlière, Marc, Calès, Paul, Guyader, Dominique, Bronowicki, Jean-Pierre, Larrey, Dominique, Hezode, Christophe, Loustaud-Ratti, Veronique, Gournay, Jerome, de Ledinghen, Victor, Asselah, Tarik, Ganne, Nathalie, Metivier, Sophie, Chazouillères, Olivier, Leroy, Vincent, Rosa, Isabelle, Samuel, Didier, Mathurin, Philippe, Cagnot, Carole, Fontaine, Helene, Carrat, Fabrice, and Pol, Stanislas

Published
2021
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5. Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Author

Renand, Amédée, Cervera-Marzal, Iñaki, Gil, Laurine, Dong, Chuang, Garcia, Alexandra, Kervagoret, Erwan, Aublé, Hélène, Habes, Sarah, Chevalier, Caroline, Vavasseur, Fabienne, Clémenceau, Béatrice, Cardon, Anaïs, Judor, Jean-Paul, Mosnier, Jean-François, Tanné, Florence, Laplaud, David-Axel, Brouard, Sophie, Gournay, Jérôme, Milpied, Pierre, and Conchon, Sophie

Published
2020
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6. Transcriptomic, clonal, and functional analyses reveal Liver tissue-imprinted immuno-profile of circulating autoreactive CD4 T cells in autoimmune liver diseases

Author

Cardon, Anais, primary, Guinebretiere, Thomas, additional, Dong, Chuang, additional, Gil, Laurine, additional, Ado, Sakina, additional, Gavlovsky, Pierre-jean, additional, Braud, Martin, additional, Danger, Richard, additional, Schultheiss, Christoph, additional, Domene, Aurelie, additional, Paul-Guilloteaux, Perrine, additional, Chevalier, Caroline, additional, Bernier, Laura, additional, Judor, Jean-Paul, additional, Fourgeux, Cynthia, additional, Imbert, Astrid, additional, Khaldi, Marion, additional, Bardou-Jacquet, Edouard, additional, Elkrief, Laure, additional, Lannes, Adrien, additional, Silvain, Christine, additional, Schnee, Mathieu, additional, Tanne, Florence, additional, Vavasseur, Fabienne, additional, Brusselle, Lucas, additional, Brouard, Sophie, additional, Kwok, William, additional, Mosnier, Jean-Francois, additional, Lohse, Ansgar W., additional, Poschmann, Jeremie, additional, Binder, Mascha, additional, Gournay, Jerome, additional, Conchon, Sophie, additional, Milpied, Pierre, additional, and Renand, Amedee, additional

Published
2024
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7. Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

Author

Barré, Tangui, Carrat, Fabrice, Ramier, Clémence, Fontaine, Hélène, Di Beo, Vincent, Bureau, Morgane, Dorival, Céline, Larrey, Dominique, Delarocque-Astagneau, Elisabeth, Mathurin, Philippe, Marcellin, Fabienne, Petrov-Sanchez, Ventzislava, Cagnot, Carole, Carrieri, Patrizia, Pol, Stanislas, Protopopescu, Camelia, Alric, Laurent, Pomes, Chloe, Zoulim, Fabien, Maynard, Marianne, Bai, Roxane, Hucault, Lucie, Bailly, François, Raffi, François, Billaud, Eric, Boutoille, David, Lefebvre, Maeva, André-Garnier, Elisabeth, Cales, Paul, Hubert, Isabelle, Lannes, Adrien, Lunel, Françoise, Boursier, Jérôme, Asselah, Tarik, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Rousseaud, Emilie, Vallet-Pichard, Anaïs, Sogni, Philippe, de Ledinghen, Victor, Foucher, Juliette, Hiriart, Jean-Baptiste, M’bouyou, Jancell, Irlès-Depé, Marie, Bourlière, Marc, Ahmed, Si Nafa Si, Oules, Valérie, Tran, Albert, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Thabut, Dominique, Hammeche, Saloua, Moussali, Joseph, Causse, Xavier, de Dieuleveult, Barbara, Ouarani, Brahim, Labarrière, Damien, Ganne, Nathalie, Grando-Lemaire, Véronique, Nahon, Pierre, Brulé, Séverine, Ulker, Betul, Guyader, Dominique, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Habersetzer, François, Baumert, Thomas, Doffoel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Bronowicki, Jean-Pierre, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Pageaux, Georges-Philippe, Meszaros, Magda, Metivier, Sophie, Bureau, Christophe, Morales, Thibault, Peron, Jean Marie, Robic, Marie Angèle, Decaens, Thomas, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Riachi, Ghassan, Goria, Odile, Paris, Fatima, Montialoux, Hélène, Leroy, Vincent, Amaddeo, Giuliana, Varaut, Anne, Simoes, Mélanie, Amzal, Rachida, Chazouillières, Olivier, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Serfaty, Lawrence, Samuel, Didier, Antonini, Teresa, Coilly, Audrey, Duclos-Vallée, Jean-Charles, Tateo, Mariagrazia, Abergel, Armand, Reymond, Maud, Brigitte, Chanteranne, Benjamin, Buchard, Muti, Léon, Geist, Claire, Conroy, Guillaume, Riffault, Raphaëlle, Rosa, Isabelle, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Loustaud-Ratti, Véronique, Carrier, Paul, Debette-Gratien, Maryline, Lassailly, Guillaume, Lemaitre, Elise, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Minello, Anne, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, D’alteroche, Louis, Barbereau, Didier, Nicolas, Charlotte, Elkrief, Laure, Jaillais, Anaïs, Gournay, Jérôme, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Portal, Isabelle, Gelu-Simeon, Moana, Saillard, Eric, Lafrance, Marie-Josée, Catherine, Lucie, Chau, Frederic, Goderel, Isabelle, Lusivika-Nzinga, Clovis, Bellance, Marc-Antoine, Bellet, Jonathan, Monfalet, Priscilla, Chane-Teng, Jessica, Bijaoui, Sephora, Pannetier, Grégory, Téoulé, François, Nicol, Jérôme, Sebal, Florian, Bekhti, Rafika, Boston, Anaïs, Nailler, Laura, Le Meut, Guillaume, Diallo, Alpha, Fourati, Slim, Housset, Chantal, Bruyand, Mathias, Wittkop, Linda, Zucman-Rossi, Jessica, L’hennaff, Marianne, Sizorn, Michèle, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Département d'hépatologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille], Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS)

Subjects
Endocannabinoid system, Behaviors, Δ9-Tetrahydrocannabinol, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Obesity, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Chronic, Body weight, Hepatitis C, Fibrosis, Corpulence, Cannabis, Marijuana
Abstract

Background Patients with chronic hepatitis C virus (HCV) infection are at greater risk of developing metabolic disorders. Obesity is a major risk factor for these disorders, and therefore, managing body weight is crucial. Cannabis use, which is common in these patients, has been associated with lower corpulence in various populations. However, this relationship has not yet been studied in persons with chronic HCV infection. Methods Using baseline data from the French ANRS CO22 Hepather cohort, we used binary logistic and multinomial logistic regression models to test for an inverse relationship between cannabis use (former/current) and (i) central obesity (i.e., large waist circumference) and (ii) overweight and obesity (i.e., elevated body mass index (BMI)) in patients from the cohort who had chronic HCV infection. We also tested for relationships between cannabis use and both waist circumference and BMI as continuous variables, using linear regression models. Results Among the 6348 participants in the study population, 55% had central obesity, 13.7% had obesity according to their BMI, and 12.4% were current cannabis users. After multivariable adjustment, current cannabis use was associated with lower risk of central obesity (adjusted odds ratio, aOR [95% confidence interval, CI]: 0.45 [0.37–0.55]), BMI-based obesity (adjusted relative risk ratio (aRRR) [95% CI]: 0.27 [0.19–0.39]), and overweight (aRRR [95% CI]: 0.47 [0.38–0.59]). This was also true for former use, but to a lesser extent. Former and current cannabis use were inversely associated with waist circumference and BMI. Conclusions We found that former and, to a greater extent, current cannabis use were consistently associated with smaller waist circumference, lower BMI, and lower risks of overweight, obesity, and central obesity in patients with chronic HCV infection. Longitudinal studies are needed to confirm these relationships and to assess the effect of cannabis use on corpulence and liver outcomes after HCV cure. Trial registration ClinicalTrials.gov identifier: NCT01953458.

Published
2022
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10. Similar 5-year HCC occurrence in Tenofovir- and Entecavir-treated HBV chronic infection in the French AFEF/ANRS CO22 Hepather cohort

Author

Pol, Stanislas, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Bailly, François, Beaudoin, Marjolaine, Giboz, Dominique, Hartig-Lavie, Kerstin, Maynard, Marianne, Billaud, Eric, Boutoille, David, Cavellec, Morane, Chevalier, Caroline, Hubert, Isabelle, Goepfert, Pierre, Lannes, Adrien, Lunel, François, Boursier, Jérôme, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Chibah, Aziza, Keser, Sylvie, Bonardi, Karim, Vallet-Pichard, Anaïs, Sogni, Philippe, Foucher, Juliette, Hiriart, Jean-Baptiste, Legendre, Amandine, Chermak, Faiza, Irlès-Depé, Marie, Ahmed, Si Nafa Si, Ansaldi, Christelle, Amara, Nisserine Ben, Oules, Valérie, Dunette, Jacqueline, Anty, Rodolphe, Gelsi, Eve, Truchi, Régin, Luckina, Elena, Messaoudi, Nadia, Moussali, Joseph, Dieuleveult, Barbara De, Goin, Héloïse, Labarrière, Damien, Potier, Pascal, Grando-Lemaire, Véronique, Nahon, Pierre, Brulé, Séverin, Monard, Rym, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Baumert, Thomas F, Dofföel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Pageaux, Georges-Philippe, Bismuth, Michael, Caillo, Ludovic, Faure, Stéphani, Ripault, Marie Pierre, Bureau, Christophe, Launay, Sarah, Peron, Jean Marie, Robic, Marie Angèl, Tarallo, Lé, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Goria, Odile, Grard, Victorien, E Montialoux, Hélè, François, Muriel, Ouedraogo, Christian, Pauleau, Christelle, Varault, Anne, Andreani, Tony, E Angoulevant, Bénédic, Chevance, Azeline, Serfaty, Lawrence, Antonini, Teresa, Coilly, Audrey, Vallée, Jean-Charles Duclos, Tateo, Mariagrazia, Bonny, Corinne, Brigitte, Chanteranne, Lamblin, Géraldin, Muti, Léo, Babouri, Abdenour, Filipe, Virginie, Barrault, Camille, Costes, Laurent, Merbah, Soraya, Carrier, Paul, Debette-Gratien, Maryline, Jacques, Jérémie, Lassailly, Guillaume, Artu, Florent, Canva, Valérie, Dharancy, Sébastie, Louvet, Alexandre, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, Bacq, Yannick, Barbereau, Didier, Nicolas, Charlotte, Archambeaud, Isabelle, Habes, Sarah, Botta-Fridlund, Danièl, Saillard, Eric, Lafrance, Marie-José, Nzinga, Clovis Luzivika, Dorival, Céline, Zoulim, Fabien, Cagnot, Carole, Decaens, Thomas, Thabut, Dominique, Asselah, Tarik, Mathurin, Philippe, Ganne, Nathalie, Samuel, Didier, Habersetzer, Françoi, Bronowicki, Jean-Pierre, Guyader, Dominique, Rosa, Isabelle, Leroy, Vincent, Chazouilleres, Olivier, Ledinghen, Victor De, Bourliere, Marc, Causse, Xavier, Cales, Paul, Metivier, Sophie, Loustaud-Ratti, Véroniqu, Abergel, Armand, Fontaine, Hélène, Carrat, Fabrice, Département d'hépatologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie du système immunitaire (Inserm U1223), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)

Subjects
MESH: Antiviral Agents, MESH: Guanine, MESH: Hepatitis B virus, MESH: Humans, MESH: Tenofovir, MESH: Hepatitis B, Chronic, MESH: Liver Neoplasms, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Carcinoma, Hepatocellular, MESH: Prospective Studies, MESH: Treatment Outcome
Abstract

International audience; Background: Chronic hepatitis B virus (HBV) infection results in a high risk of cirrhosis and its complications, cirrhosis decompensation (DC), hepatocellular carcinoma (HCC), liver transplantation (LT), death or any of these outcomes (composite endpoint [CE]). Nucleos(t)ide analogues (NUCs) such as tenofovir or entecavir are associated with a reduction in these complications.Aim: To compare the impact of tenofovir and entecavir on these outcomes in patients treated for HBV infection and included in the prospective Hepather cohort.Methods: All patients with HBV infection who had received tenofovir or entecavir for more than 6 months at or after entry in the ANRS CO22 cohort were selected. Patients with HDV and HCV co-infection or prior liver event were excluded. Incidence rates of events were compared using inverse probability of treatment weighting (IPW).Results: The cohort included 1800 patients (986 tenofovir and 814 entecavir). Median follow-up was 4.2 years. The incidences of HCC, DC, LT, ACD, LRD and CE were not different between tenofovir- (1.8 (0.9; 3.2), 0.6 (0.2; 1.6), 0.2 (0.0; 0.8), 1.7 (0.8; 3.0), 0.8 (0.2, 1.8) and 4.1 (3.0; 5.4) per 1000 person-years) and entecavir-treated patients (1.6 (0.7; 3.0), 0.7 (0.2; 1.8), 0.2 (0.0; 1.0), 3.0 (1.7, 4.8), 0.5 (0.1; 1.5) and 5.0 (3.3; 7.2)) per 1000 person-years, respectively.Conclusion: The risk of liver-related events or death was not different between tenofovir- and entecavir-treated patients in this large prospective cohort of predominantly non-cirrhotic French patients.Trial registration number: NCT019553458.

Published
2021
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11. Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)

Author

Barré, Tangui, Pol, Stanislas, Ramier, Clémence, Di Beo, Vincent, Carrat, Fabrice, Bureau, Morgane, Bourlière, Marc, Dorival, Céline, Serfaty, Lawrence, Asselah, Tarik, Boursier, Jérôme, Marcellin, Fabienne, Carrieri, Patrizia, Fontaine, Hélène, Protopopescu, Camelia, Alric, Laurent, Bonnet, Delphine, Payssan-Sicart, Virginie, Pomes, Chloe, Zoulim, Fabien, Maynard, Marianne, Bai, Roxane, Hucault, Lucie, Bailly, François, Raffi, François, Billaud, Eric, Boutoille, David, Lefebvre, Maeva, André-Garnier, Elisabeth, Cales, Paul, Hubert, Isabelle, Lannes, Adrien, Lunel, Françoise, Boyer, Nathalie, Giuily, Nathalie, Castelnau, Corinne, Scoazec, Giovanna, Rousseaud, Emilie, Vallet-Pichard, Anaïs, Sogni, Philippe, Ledinghen, Victor De, Foucher, Juliette, Hiriart, Jean-Baptiste, M'Bouyou, Jancell, Irlès-Depé, Marie, Si Ahmed, Si Nafa, Oules, Valérie, Tran, Albert, Anty, Rodolphe, Gelsi, Eve, Truchi, Régine, Thabut, Dominique, Hammeche, Saloua, Moussali, Joseph, Causse, Xavier, Dieuleveult, Barbara De, Ouarani, Brahim, Labarrière, Damien, Ganne, Nathalie, Grando-Lemaire, Véronique, Nahon, Pierre, Brulé, Séverine, Ulker, Betul, Guyader, Dominique, Jezequel, Caroline, Brener, Audrey, Laligant, Anne, Rabot, Aline, Renard, Isabelle, Habersetzer, François, Baumert, Thomas, Doffoel, Michel, Mutter, Catherine, Simo-Noumbissie, Pauline, Razi, Esma, Bronowicki, Jean-Pierre, Barraud, Hélène, Bensenane, Mouni, Nani, Abdelbasset, Hassani-Nani, Sarah, Bernard, Marie-Albertine, Pageaux, Georges-Philippe, Larrey, Dominique, Meszaros, Magda, Metivier, Sophie, Bureau, Christophe, Morales, Thibault, Peron, Jean Marie, Robic, Marie Angèle, Decaens, Thomas, Faure, Marine, Froissart, Bruno, Hilleret, Marie-Noelle, Zarski, Jean-Pierre, Riachi, Ghassan, Goria, Odile, Paris, Fatima, Montialoux, Hélène, Leroy, Vincent, Amaddeo, Giuliana, Varaut, Anne, Simoes, Mélanie, Amzal, Rachida, Chazouillières, Olivier, Andreani, Tony, Angoulevant, Bénédicte, Chevance, Azeline, Samuel, Didier, Antonini, Teresa, Coilly, Audrey, Duclos Vallée, Jean-Charles, Tateo, Mariagrazia, Abergel, Armand, Reymond, Maud, Brigitte, Chanteranne, Benjamin, Buchard, Muti, Léon, Geist, Claire, Conroy, Guillaume, Riffault, Raphaëlle, Rosa, Isabelle, Barrault, Camille, Costes, Laurent, Hagège, Hervé, Loustaud-Ratti, Véronique, Carrier, Paul, Debette-Gratien, Maryline, Mathurin, Philippe, Lassailly, Guillaume, Lemaitre, Elise, Canva, Valérie, Dharancy, Sébastien, Louvet, Alexandre, Minello, Anne, Latournerie, Marianne, Bardou, Marc, Mouillot, Thomas, d'Alteroche, Louis, Barbereau, Didier, Nicolas, Charlotte, Elkrief, Laure, Jaillais, Anaïs, Gournay, Jérôme, Chevalier, Caroline, Archambeaud, Isabelle, Habes, Sarah, Portal, Isabelle, Gelu-Simeon, Moana, Saillard, Eric, Lafrance, Marie-Josée, Catherine, Lucie, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépatologie médicale [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépato-gastro-entérologie, Assistance Publique - Hôpitaux de Marseille (APHM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Hôpital de Hautepierre [Strasbourg], Service d’Hépatologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and BOURGEAIS, Véronique

Subjects
Hepatitis B virus, medicine.medical_specialty, Cirrhosis, [SDV]Life Sciences [q-bio], Aucun, Overweight, medicine.disease_cause, Virus, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Internal medicine, medicine, Humans, Pharmacology (medical), Obesity, ComputingMilieux_MISCELLANEOUS, Cannabis, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, Cannabinoids, business.industry, Liver Neoplasms, Hepatitis B, biology.organism_classification, medicine.disease, digestive system diseases, 3. Good health, [SDV] Life Sciences [q-bio], Complementary and alternative medicine, Hepatocellular carcinoma, Cohort, cannabis, obesity, overweight, socioeconomic status, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

International audience; Background: Chronic hepatitis B virus (HBV) infection may evolve into cirrhosis and hepatocellular carcinoma, and this progression may be accelerated by specific risk factors, including overweight and obesity. Although evidence for a protective effect of cannabis use on elevated body weight has been found for other populations, no data are available for HBV-infected patients.Aims: We aimed to identify risk factors (including cannabis use) for overweight and obesity in patients with HBV chronic infection.Methods: Using baseline data from the French ANRS CO22 Hepather cohort, we performed two separate analyses, one using “central obesity” (based on waist circumference) and the other “overweight” and “obesity” (based on body mass index) as outcomes. Logistic and multinomial regressions were used to model central obesity and overweight/obesity, respectively.Results: Among the 3706 patients in the study population, 50.8% had central obesity, 34.7% overweight, and 14.4% obesity. After multivariable adjustment, current cannabis use was associated with a 59% lower risk of central obesity compared with no lifetime use (adjusted odds ratio [95% CI]: 0.41 [0.24 to 0.70]). It was also associated with a 54% and 84% lower risk of overweight (adjusted relative risk ratio [95% CI]: 0.46 [0.27 to 0.76]) and obesity (0.16 [0.04 to 0.67]), respectively.Conclusions: Cannabis use was associated with lower risks of overweight and obesity in patients with HBV chronic infection. Future studies should test whether these potential benefits of cannabis and cannabinoid use translate into reduced liver disease progression in this high-risk population.

Published
2021
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13. Absence of impact of direct acting antivirals for hepatitis C virus on recurrent hepatocellular carcinoma tumor growth in the AFEF/ANRS CO22 Hepather cohort

Author

Vallet-Pichard, Anais, primary, Correas, Jean-Michel, additional, Dorival, Celine, additional, Zoulim, Fabien, additional, Tran, Albert, additional, Bourlière, Marc, additional, Calès, Paul, additional, Guyader, Dominique, additional, Bronowicki, Jean-Pierre, additional, Larrey, Dominique, additional, Hezode, Christophe, additional, Loustaud-Ratti, Veronique, additional, Gournay, Jerome, additional, de Ledinghen, Victor, additional, Asselah, Tarik, additional, Ganne, Nathalie, additional, Metivier, Sophie, additional, Chazouillères, Olivier, additional, Leroy, Vincent, additional, Rosa, Isabelle, additional, Samuel, Didier, additional, Mathurin, Philippe, additional, Cagnot, Carole, additional, Fontaine, Helene, additional, Carrat, Fabrice, additional, Pol, Stanislas, additional, Bonnet, Delphine, additional, Payssan-Sicart, Virginie, additional, Pomes, Chloe, additional, Bailly, François, additional, Beaudoin, Marjolaine, additional, Giboz, Dominique, additional, Hartig-Lavie, Kerstin, additional, Maynard, Marianne, additional, Billaud, Eric, additional, Boutoille, David, additional, Cavellec, Morane, additional, Cheraud-Carpentier, Marjorie, additional, Hubert, Isabelle, additional, Benhida, Jaouad, additional, Lannes, Adrien, additional, Lunel, Françoise, additional, Oberti, Frédéric, additional, Boyer, Nathalie, additional, Giuily, Nathalie, additional, Castelnau, Corinne, additional, Scoazec, Giovanna, additional, Chibah, Aziza, additional, Keser, Sylvie, additional, Bonardi, Karim, additional, Vallet-Pichard, Anaïs, additional, Sogni, Philippe, additional, Foucher, Juliette, additional, Hiriart, Jean-Baptiste, additional, Wilson, Amy, additional, Shili, Sarah, additional, Chermak, Faiza, additional, Ansaldi, Christelle, additional, Amara, Nisserine Ben, additional, Chouquet, Laëtitia, additional, De Luca, Emilie, additional, Oules, Valérie, additional, Anty, Rodolphe, additional, Gelsi, Eve, additional, Truchi, Régine, additional, Luckina, Elena, additional, Messaoudi, Nadia, additional, Moussali, Joseph, additional, De Dieuleveult, Barbara, additional, Labarriere, Damien, additional, Poter, Pascal, additional, Ahmed, Si Nafa Si, additional, Grando-Lemaire, Véronique, additional, Nahon, Pierre, additional, Bourcier, Valérie, additional, Brulé, Séverine, additional, Stalhberger, Thomas, additional, Jezequel, Caroline, additional, Brener, Audrey, additional, Laligant, Anne, additional, Rabot, Aline, additional, Renard, Isabelle, additional, Baumert, Thomas F., additional, Dofföel, Michel, additional, Mutter, Catherine, additional, Simo-Noumbissie, Pauline, additional, Razi, Esma, additional, Barraud, Hélène, additional, Bensenane, Mouni, additional, Nani, Abdelbasset, additional, Hassani-Nani, Sarah, additional, Bernard, Marie-Albertine, additional, Pageaux, Georges-Philippe, additional, Bismuth, Michael, additional, Caillo, Ludovic, additional, Faure, Stéphanie, additional, Ripault, Marie-Pierre, additional, Bureau, Christophe, additional, Peron, Jean Marie, additional, Robic, Marie-Angèle, additional, Tarallo, Léa, additional, Faure, Marine, additional, Froissart, Bruno, additional, Hilleret, Marie-Noelle, additional, Zarski, Jean-Pierre, additional, Goria, Odile, additional, Grard, Victorien, additional, Montialoux, Hélène, additional, François, Muriel, additional, Ouedraogo, Christian, additional, Pauleau, Christelle, additional, Varault, Anne, additional, Andreani, Tony, additional, Angoulevant, Bénédicte, additional, Chevance, Azeline, additional, Serfaty, Lawrence, additional, Antonini, Teresa, additional, Coilly, Audrey, additional, Vallée, Jean-Charles Duclos, additional, Tateo, Mariagrazia, additional, Bonny, Corinne, additional, Brigitte, Chanteranne, additional, Lamblin, Géraldine, additional, Muti, Léon, additional, Babouri, Abdenour, additional, Filipe, Virginie, additional, Barrault, Camille, additional, Costes, Laurent, additional, Hagège, Hervé, additional, Merbah, Soraya, additional, Carrier, Paul, additional, Debette-Gratien, Maryline, additional, Jacques, Jérémie, additional, Lassailly, Guillaume, additional, Artu, Florent, additional, Canva, Valérie, additional, Dharancy, Sébastien, additional, Louvet, Alexandre, additional, Latournerie, Marianne, additional, Bardou, Marc, additional, Mouillot, Thomas, additional, Bacq, Yannick, additional, Barbereau, Didier, additional, Nicolas, Charlotte, additional, Chevalier, Caroline, additional, Archambeaud, Isabelle, additional, Habes, Sarah, additional, Botta-Fridlund, Danièle, additional, Saillard, Eric, additional, and Lafrance, Marie-Josée, additional

Published
2021
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16. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

Author

Yu-Wai-Man, Patrick, primary, Newman, Nancy J., additional, Carelli, Valerio, additional, Moster, Mark L., additional, Biousse, Valerie, additional, Sadun, Alfredo A., additional, Klopstock, Thomas, additional, Vignal-Clermont, Catherine, additional, Sergott, Robert C., additional, Rudolph, Günther, additional, La Morgia, Chiara, additional, Karanjia, Rustum, additional, Taiel, Magali, additional, Blouin, Laure, additional, Burguière, Pierre, additional, Smits, Gerard, additional, Chevalier, Caroline, additional, Masonson, Harvey, additional, Salermo, Yordak, additional, Katz, Barrett, additional, Picaud, Serge, additional, Calkins, David J., additional, and Sahel, José-Alain, additional

Published
2020
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17. rAAV2/2-ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): Final Results from the RESCUE and REVERSE Phase III Clinical Trials and Experimental Data in Nonhuman Primates to Support a Bilateral Effect (2339)

Author

Moster, Mark, primary, Sadun, Alfredo, additional, Klopstock, Thomas, additional, Newman, Nancy, additional, Vignal-Clermont, Catherine, additional, Carelli, Valerio, additional, Yu-Wai-Man, Patrick, additional, Biousse, Valerie, additional, Sergott, Robert, additional, Katz, Barrett, additional, DeBusk, Adam, additional, Blouin, Laure, additional, Chevalier, Caroline, additional, Burguiere, Pierre, additional, Taiel, Magali, additional, and Sahel, Jose-Alain, additional

Published
2020
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19. Article 5. Crimes relevant de la compétence de la Cour (Chapitre II. Compétence, recevabilité et droit applicable)

Author

Marie, Elsa, Laly Chevalier, Caroline, Centre de recherche Droits et perspectives du droit - ULR 4487 (CRDP), Université de Lille, Fernandez, Julian, Pacreau, Xavier, and Ubéda-Saillard, Muriel

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law
Abstract

Le Statut de Rome a été conclu le 17 juillet 1998 et il est entré en vigueur le 1er juillet 2002. Depuis, les chambres de la Cour pénale internationale ont déjà fait œuvre d’un intense travail judiciaire en parallèle d’une politique pénale développée par les procureurs Luis Moreno Ocampo et Fatou Bensouda. Qu’elle soit saisie par les Etats, par le Conseil de sécurité ou par le Procureur agissant proprio motu, la première juridiction pénale internationale permanente s’est imposée comme un acteur incontournable des relations internationales dont le Statut constitutif est opposable à plus de 120 Etats. Cette nouvelle édition du Commentaire du Statut de Rome, article par article, propose une analyse précise des 128 dispositions du Statut, complétée par plusieurs contributions préalables transversales qui abordent des aspects ne pouvant être traités de façon exhaustive dans le corps de l’ouvrage. A cette fin sont rassemblées les contributions de 125 auteurs qu’ils soient universitaires, membres des différents organes de la Cour, conseils et membres d’autres organisations internationales ou d’institutions nationales dont l’activité est liée à l’action de la juridiction. Unique commentaire francophone dédié à la Cour pénale internationale, cet ouvrage de référence, primé par l’Institut de France, se veut tant au service de la recherche que de la pratique.

Published
2019

20. Influence des paramètres des structures fibreuses et tissées sous charges dynamiques

Author

Boussu, François, Chevalier, Caroline, Kerisit, Christophe, Klavzar, Andreas, Coutellier, Daniel, Association Française de Mécanique, and Service irevues, irevues

Subjects
paramètres dynamiques, aramide, Caractérisation dynamique, fil para, [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics], procédé de mesure expérimental, taux de déformation
Abstract

Colloque avec actes et comité de lecture. Internationale.; International audience; Le développement de nouvelles solutions de protection balistique nécessite des simulations numériques, afin de prédire leurs performances et leurs effets secondaires. Les mécanismes induits dans les tissus balistiques lors d'un impact dépendent des paramètres de tissage mais aussi des paramètres internes des fils utilisés dans ces structures. Ainsi, connaître le comportement dynamique du fil est essentiel pour déterminer le comportement balistique des tissus lors d'un impact. Ce travail vise à étudier le comportement mécanique d'un fil para-aramide en charge dynamique et longitudinale. À cette fin, nous avons conçu un nouveau dispositif expérimental pour réaliser ces essais à l'aide d'un canon à gaz: le Dispositif de Traction par Impact sur Fil (DTIF). Des campagnes d'essais ont été réalisées pour identifier les paramètres dynamiques d'un fil vierge, ainsi que de caractériser l'influence de l'arrangement structurel du tissu sur le comportement dynamique d'un fil.

Published
2017

21. Statut de réfugié et droits politiques : à la recherche d'un compromis en droit international

Author

UCL - SSH/JURI - Institut pour la recherche interdisciplinaire en sciences juridiques, UCL - Faculté de droit et de criminologie, Saroléa, Sylvie, Schamps, Geneviève, Carlier, Jean-Yves, Fierens, Jacques, Laly-Chevalier, Caroline, Crépeau, François, Mangala, Jack, Maheshe Musole, Tresor, UCL - SSH/JURI - Institut pour la recherche interdisciplinaire en sciences juridiques, UCL - Faculté de droit et de criminologie, Saroléa, Sylvie, Schamps, Geneviève, Carlier, Jean-Yves, Fierens, Jacques, Laly-Chevalier, Caroline, Crépeau, François, Mangala, Jack, and Maheshe Musole, Tresor

Abstract

Political rights of refugees are subject to several limitations in the international legal system. The present research ponders the conformity of such limitations with respect to the condition of legality, legitimacy and proportionality accepted in human rights. The intention is to reconcile political rights with refugee status from Hannah Arendt’s political thinking. The approach distinguishes reasonable from unreasonable limitations. On the one hand, the limitations to right of political nature (freedom of expression, association and assembly) are described as unreasonable due to the lack of conformity with respect to legality, legitimacy and proportionality conditions. This consequently reconcile refugee status with rights of a political nature. On the other hand, limitations to political rights in the strict sense (right to vote and eligibility) are considered reasonable due to their compliance with the conditions of citizenship and residence. This gives rise to an hindrance as for refugees to exercise their political rights in the strict sense, both in the host country and in the home country. To bypass this obstacle, this research suggests the cessation of refugee status., Les droits politiques des réfugiés sont soumis à plusieurs limitations dans l’ordre juridique international. La présente recherche s’interroge sur la conformité de telles limitations aux conditions de légalité, de légitimité et de proportionnalité admises en droits de l’homme. Elle part Le but est de concilier les droits politiques avec le statut de réfugié à partir de la pensée politique d’Hannah Arendt. La démarche distingue les limitations raisonnables de celles qui sont déraisonnables. D’un côté, les limitations aux droits de nature politique (libertés d’expression, d’association et de réunion) sont qualifiées de déraisonnables en raison de l’absence de conformité avec les conditions de légalité, de légitimité et de proportionnalité. Cela a pour effet de concilier le statut de réfugié avec les droits de nature politique. De l’autre, les limitations aux droits politiques au sens strict (droit de vote et d’éligibilité) sont jugées raisonnables en raison de leur conformité aux conditions de citoyenneté et de résidence. Il s’ensuit une entrave à l’exercice des droits politiques au sens strict des réfugiés aussi bien dans le pays d’accueil que dans celui d’origine. Pour contourner cet obstacle, la présente recherche propose la cessation de la qualité de réfugié., (DROI - Sciences juridiques) -- UCL, 2018

Published
2018

22. Characterization of the longitudinal mechanical behavior of a para-aramid yarn in dynamic load

Author

Chevalier, Caroline, Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Université de Valenciennes et du Hainaut-Cambresis, Daniel Coutellier, and François Boussu

Subjects
Dispositif de traction par impact sur fil, Canon à gaz, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], Dynamic characterization, Caractérisation dynamique, Fil de para-Aramide, Tension impact test for yarn, Para-Aramid yarn, Gas gun
Abstract

This work aims at studying the mechanical behavior of a para-aramid yarn in dynamic and longitudinal load. To that end, we designed a new experimental device to achieve these tests with the use of a gas gun: the Tensile Impact Test for Yarn (TITY). This device met numerous modifications in the aim to reach optimal test conditions. It is associated with a measurement device using laser and allowing obtaining the velocity profile of the projectile and the Strength-Strain characteristic curves of the tested yarn. The validity of the measure is confirmed by comparing our results with those obtained with a laser Doppler vélocimètre, device allowing measuring directly and precisely the velocity profile of the projectile. Many test campaigns are performed. Both in the aim to identify the dynamic parameters of a single and virgin yarn, and in the aim to characterize the impact of the fabric structural arrangement on the dynamic behavior of a yarn. This study reveals the intervention of three main structural parameters, which are the total inter-yarns contact surface, the number of binding points and the transvers and lateral inter-yarns pressures, having an impact on four main yarn break criteria, which are the structural defects and hysteresis phenomena inside the filament, stress concentrations and frictional forces concerning the interactions between the tested yarn and the rest of the fabric.; Ce travail a pour objectif d’étudier le comportement mécanique d’un fil de para-aramide en sollicitation longitudinale et dynamique. Pour ce faire, nous avons conçu un nouveau dispositif expérimental permettant de réaliser ces essais à l’aide d’un canon à gaz : le Dispositif de Traction par Impact sur Fil (DTIF). Ce dispositif a subi de nombreuses modifications dans le but d’obtenir des conditions d’essais optimales. Celui-ci est associé à un dispositif de mesure par laser permettant d’obtenir le profil de vitesse du projectile ainsi que les courbes caractéristiques de Force-Déformation du fil testé. La validité de la mesure est confirmée par comparaison aux résultats obtenus avec un vélocimètre à effet Doppler, dispositif permettant de mesurer directement et de façon précise le profil de vitesse du projectile. Plusieurs campagnes d’essais sont réalisées, à la fois dans le but d’identifier les caractéristiques dynamiques d’un fil seul, et dans le but de caractériser l’influence de l’arrangement structural d’un tissu sur le comportement dynamique d’un fil. Cette étude révèle l’intervention de trois principaux paramètres structuraux, qui sont la surface de contact inter-fils totale, le nombre de points de liage et les pressions inter-fils transverses et latérales au sein du tissu, influant sur quatre principaux critères de rupture du fil, qui sont les défauts de structure et les phénomènes d’hystérésis au sein du filament, les concentrations de contraintes ainsi que les forces de frottement au niveau des interactions entre le fil testé et le reste de la structure tissée.

Published
2016

24. A new experimental setup to characterize the dynamic mechanical behaviour of ballistic yarns

Author

Chevalier, Caroline, Faderl, N., Kerisit, Christophe, Coutellier, Daniel, Boussu, François, Institut franco-allemand de recherches de Saint-Louis (ISL), DGA-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), and Ecole nationale supérieure des arts et industries textiles de Roubaix (ENSAIT)

Subjects
[SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]
Abstract

International audience; Fabrics have been widely used as part of ballistic protections since the 1970s and the development of new ballistic solutions made from fabrics need numerical simulations, in order to predict the performance of the ballistic protection. The performances and the induced mechanisms in ballistic fabrics during an impact depend on the weaving parameters and also on the inner parameters of the yarns used inside these structures. Thus, knowing the dynamic behaviour of yarn is essential to determine the ballistic behaviour of fabrics during an impact.Two major experimental devices exist and are used to test ballistic yarns in a dynamic uniaxial tension. The first one corresponds to the Split Hopkinson Tensile Bars device, which is commonly used to characterize the mechanical properties of materials in uniaxial tension and under high loading. The second one is the transversal impact device. The real conditions of ballistic impact can be realized with this device.Then, this paper deals with a new experimental setup developed in our laboratory and called the ‘tensile impact test for yarn’ (TITY) device. With this device, specific absorbed energy measurements of para-aramid yarns (336 Tex, Twaron™, 1000 filaments) have been carried out and revealed that static and dynamic properties of para-aramid are different.

Published
2015

25. Les problèmes d'articulation des procédures d'asile, d'extradition et d'entraide judiciaire pénale

Author

Forteau, Mathias, Laly-Chevalier, Caroline, Centre de droit international de Nanterre (CEDIN), Université Paris Nanterre (UPN), Chetail, Vincent and Laly-Chevalier, Caroline, HAL Nanterre, Administrateur, and Chetail, Vincent and Laly-Chevalier, Caroline

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Droit d'asile ― Pays de l'Union européenne ― Études comparatives, Réfugiés ― Statut juridique, Extradition ― Pays de l'Union européenne ― Études comparatives, Convention relative au statut des réfugiés (1951)
Abstract

National audience; La présente étude a pour objet d'analyser les relations denses et complexes entre l'extradition et l'exclusion du statut de réfugié.

Published
2012

26. Dynamic Mechanical Behavior Of Yarn Under High Speed Loading

Author

Chevalier, Caroline, Boussu, François, Klavzar, Andreas, Kerisit, Christophe, Coutellier, Daniel, Institut franco-allemand de recherches de Saint-Louis (ISL), DGA-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ecole nationale supérieure des arts et industries textiles de Roubaix (ENSAIT), Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), and Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)

Subjects
"high strain rate", "ballistic fabrics", "yarn", "experimental setups", [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], "dynamic parameters", ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

27. Characterization of the dynamic behavior of yarns for the modeling of ballistic fabrics

Author

Chevalier, Caroline, Kerisit, Christophe, Klavzar, Andreas, Coutellier, Daniel, Boussu, François, Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), and Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)

Subjects
yarn, high strain rate, ballistic fabrics, dynamic parameters, [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, experimental setups
Abstract

International audience; The use of fabrics as part of ballistic protections is widely spread since 70’s. The development of these new ballistic solutions needs numerical simulations, in order to predict the performance of the ballistic protection and the potential secondary effect. The performances and the induced mechanisms in ballistic fabrics during an impact depend on the weaving parameters and also on inner parameters of yarns used in these structures. Thus, knowing the dynamic behavior of yarn is essential to determined the ballistic behavior of fabrics during an impact. For this purpose, we use four experimental setups in order to reveal dynamic parameters of ballistic yarn during high speed mechanical stress.

Published
2014

28. Experimental study on the influence of weaving parameters on the ballistic performances of 3D fabrics

Author

Chevalier, Caroline, Nussbaum, Julien, Coutellier, Daniel, Boussu, François, Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 (LAMIH), and Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Centre National de la Recherche Scientifique (CNRS)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)

Subjects
[SPI]Engineering Sciences [physics], [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]
Abstract

International audience; This paper deals with the study of weaving parameters and their influence on the ballistic performances of 3D fabrics. The goal is to better understand how such fabrics behave when they undertake impact loadings and to find some ways to improve their capacity to absorb the kinetic energy of projectiles. The study is focused on the layer-to-layer interlocks. As varying parameters, we study the material (aramid and polyethylene), the yarn density, the number of inner layer of the structure and the total areal density of the samples. Ballistic tests with 5 mm steel balls at different velocities are performed. Residual velocities after perforation are evaluated by high speed camera or X-ray pictures. Analysis of the experimental results and perspectives on future works are then given.

Published
2013

30. Psychopathy Checklist-Revised Use and Reporting Practices in Sexually Violent Predator Evaluations.

Author

Boccaccini, Marcus T., Chevalier, Caroline S., Murrie, Daniel C., and Varela, Jorge G.

Subjects
PSYCHOLOGY of sex offenders, HARE Psychopathy Checklist
Abstract

We surveyed evaluators who conduct sexually violent predator evaluations ( N = 95) regarding the frequency with which they use the Psychopathy Checklist-Revised (PCL-R), their rationale for use, and scoring practices. Findings suggest that evaluators use the PCL-R in sexually violent predator cases because of its perceived versatility, providing information about both mental disorder and risk. Several findings suggested gaps between research and routine practice. For example, relatively few evaluators reported providing the factor and facet scores that may be the strongest predictors of future offending, and many assessed the combination of PCL-R scores and sexual deviance using deviance measures (e.g., paraphilia diagnoses) that have not been examined in available studies. There was evidence of adversarial allegiance in PCL-R score interpretation, as well as a "bias blind spot" in PCL-R and other risk measure (Static-99R) scoring; evaluators tended to acknowledge the possibility of bias in other evaluators but not in themselves. Findings suggest the need for evaluators to carefully consider the extent to which their practices are consistent with emerging research and to be attuned to the possibility that working in adversarial settings may influence their scoring and interpretation practices. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
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40. Bilateral Visual Improvement with Unilateral Gene Therapy Injection for Leber Hereditary Optic Neuropathy

Author

Yu-Wai-Man, Patrick, Newman, Nancy J, Carelli, Valerio, Moster, Mark L, Biousse, Valerie, Sadun, Alfredo A, Klopstock, Thomas, Vignal-Clermont, Catherine, Sergott, Robert C, Rudolph, Günther, La Morgia, Chiara, Karanjia, Rustum, Taiel, Magali, Blouin, Laure, Burguière, Pierre, Smits, Gerard, Chevalier, Caroline, Masonson, Harvey, Salermo, Yordak, Katz, Barrett, Picaud, Serge, Calkins, David J, and Sahel, José-Alain

Subjects
genetic structures, Visual Acuity, Animals, NADH Dehydrogenase, sense organs, Genetic Therapy, Optic Atrophy, Hereditary, Leber, Dependovirus, Visual Fields, eye diseases, Tomography, Optical Coherence, 3. Good health
Abstract

REVERSE is a randomized, double-masked, sham-controlled, multicenter, phase III clinical trial that evaluated the efficacy of a single intravitreal injection of rAAV2/2 ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). A total of 37 subjects carrying the m.11778G>A (MT-ND4) mutation and with duration of vision loss between 6 to 12 months were treated. Each subject’s right eye was randomly assigned in a 1:1 ratio to treatment with rAAV2/2 ND4 (GS010) or sham injection. The left eye received the treatment not allocated to the right eye. Unexpectedly, sustained visual improvement was observed in both eyes over the 96-week follow-up period. At Week 96, rAAV2/2 ND4-treated eyes showed a mean improvement in best-corrected visual acuity (BCVA) of -0.308 LogMAR (+15 ETDRS letters). A mean improvement of 0.259 (0.068) LogMAR (+13 ETDRS letters) was observed in the sham treated eyes. Consequently, the primary endpoint, defined as the difference in the change in BCVA from baseline to Week 48 between the two treatment groups, was not met (p = 0.894, ANCOVA). At Week 96, 25 subjects (68%) had a clinically relevant recovery in BCVA from baseline in at least one eye and 29 subjects (78%) had an improvement in vision in both eyes. A non-human primate study was conducted to investigate this bilateral improvement. Evidence of transfer of viral vector DNA from the injected eye to the anterior segment, retina and optic nerve of the contralateral non-injected eye supports a plausible mechanistic explanation for the unexpected bilateral improvement in visual function after unilateral injection.

41. Demandeurs d'asile déboutés : la stratégie de l'inespoir

Author

Slama, Serge, Centre de Théorie et Analyse du Droit (CTAD), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Centre de recherches et d'études sur les droits fondamentaux (CREDOF), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Fernández, Julián, Laly-Chevalier, Caroline, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), and HAL Nanterre, Administrateur

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law, Droit d'asile -- France, France, Production légale d'illégalité, Etrangers, Déboutés
Abstract

National audience; à venir

Published
2015

42. Accorder l'asile ou extrader ? Recherche sur la jurisprudence du Conseil d'État sur l'articulation entre le statut de réfugié et le droit de l'extradition

Author

Slama, Serge, Centre de Théorie et Analyse du Droit (CTAD), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Centre de recherches et d'études sur les droits fondamentaux (CREDOF), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Chetail, Vincent and Laly-Chevalier, Caroline, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), HAL Nanterre, Administrateur, and Chetail, Vincent and Laly-Chevalier, Caroline

Subjects
[SHS.DROIT]Humanities and Social Sciences/Law, [SHS.DROIT] Humanities and Social Sciences/Law
Abstract

National audience; à venir

Published
2014

44. Psychopathy Checklist-Revised Use and Reporting Practices in Sexually Violent Predator Evaluations.

Author

Boccaccini MT, Chevalier CS, Murrie DC, and Varela JG

Subjects
Antisocial Personality Disorder psychology, Forensic Psychiatry, Humans, Male, Psychometrics, Reproducibility of Results, Antisocial Personality Disorder diagnosis, Checklist, Criminals psychology, Sex Offenses psychology, Violence psychology
Abstract

We surveyed evaluators who conduct sexually violent predator evaluations ( N = 95) regarding the frequency with which they use the Psychopathy Checklist-Revised (PCL-R), their rationale for use, and scoring practices. Findings suggest that evaluators use the PCL-R in sexually violent predator cases because of its perceived versatility, providing information about both mental disorder and risk. Several findings suggested gaps between research and routine practice. For example, relatively few evaluators reported providing the factor and facet scores that may be the strongest predictors of future offending, and many assessed the combination of PCL-R scores and sexual deviance using deviance measures (e.g., paraphilia diagnoses) that have not been examined in available studies. There was evidence of adversarial allegiance in PCL-R score interpretation, as well as a "bias blind spot" in PCL-R and other risk measure (Static-99R) scoring; evaluators tended to acknowledge the possibility of bias in other evaluators but not in themselves. Findings suggest the need for evaluators to carefully consider the extent to which their practices are consistent with emerging research and to be attuned to the possibility that working in adversarial settings may influence their scoring and interpretation practices.

Published
2017
Full Text
View/download PDF

45. Development of a geographic information-driven real-time surveillance system for disease surveillance.

Author

Shuai J, Buck P, Chevalier C, and Sockett P

Abstract

To respond to emerging public health threats such as West Nile virus, an advanced geographic information systems (GIS) -driven Web-based real-time surveillance system was developed to serve the National West Nile virus dead bird surveillance programme in Canada. The development of this system uses real-time Web GIS technologies and services to enhance conventional real-time surveillance systems based on real-time GIS requirements. The system has three modules: QuickTrack, QuickMap and QuickManage. QuickTrack is the real-time surveillance module that supports data collection, edit and transfer. QuickMap is the real-time Web GIS module that provides comprehensive real-time GIS supports and services in public health surveillance and information sharing. The QuickManage module is a Web-based system management package used to manage the entire system. This system offers an effective approach to enhance real-time public health surveillance systems by integrating real-time Web GIS technologies and services. The system demonstrates that real-time Web GIS technologies can play an important role in enhancing public health surveillance systems.

Published
2007

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