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5 results on '"Cheret, G."'

1. Complete DNA sequence of yeast chromosome XI

Author

Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J.P.G., Banrevl, A., P.A. Bolle, Boloth-Fukuhara, M., Bossier, P., Bou, G., Boyer, J., Bultrago, M.J., Cheret, G., Colleaux, L., Dalgnan-Fronier, B., Rey, F. del, Dlon, C., Domdey, H., Dusterhoft, A., Dusterhus, S., Entian, K.-D., Erfle, H., Esteban, P.F., and Feldmann, H.

Subjects
Nucleotide sequence -- Analysis, Chromosomes -- Research, Yeast -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Determination of the complete DNA sequence of yeast chromosome XI reveals facts regarding certain unique genes. Homologues to genes that perform varied functions in multicellular organisms are used to identify the gene function or to develop new therapeutic agents. These unique genes are also involved in human pathologies such as xeroderma pigmentosum or adrenoleukodistrophy.

Published
1994

2. The nucleotide sequence of Saccharomyces cerevisiae chromosome XV

Author

Dujon, B, Albermann, K, Aldea, M, Alexandraki, D, Ansorge, W, Arino, J, Benes, V, Bohn, C, BolotinFukuhara, M, Bordonne, R, Boyer, J, Camasses, A, Casamayor, A, Casas, C, Cheret, G, Cziepluch, C, DaignanFornier, B, Dang, V, deHaan, M, Delius, H, Durand, P, Fairhead, C, Feldmann, H, Gaillon, L, Galisson, F, Gamo, J, Gancedo, C, Goffeau, A, Goulding, E, Grivell, A, Habbig, B, Hand, J, Hani, J, Hattenhorst, U, Hebling, U, Hernando, Y, Herrero, E, Heumann, K, Hiesel, R, Hilger, F, Hofmann, B, Hollenberg, P, Hughes, B, Jauniaux, C, Kalogeropoulos, A, Katsoulou, C, Kordes, E, Lafuente, J, Landt, O, Louis, J, Maarse, C, Madania, A, Mannhaupt, G, Marck, C, Martin, P, Mewes, W, Michaux, G, Paces, V, ParleMcDermott, G, Pearson, M, Perrin, A, Pettersson, B, Poch, O, Pohl, M, Poirey, R, Portetelle, D, Pujol, A, Purnelle, B, Rad, R, Rechmann, S, Schwager, C, Schweizer, M, Sor, F, Sterky, Fredrik, Tarassov, A, Teodoru, C, Tettelin, H, Thierry, A, Tobiasch, E, Tzermia, M, Uhlen, Mathias, Unseld, M, Valens, M, Vandenbol, M, Vetter, I, Vicek, C, Voet, M, Volckaert, G, Voss, H, Wambutt, R, Wedler, H, Wiemann, S, Winsor, B, Wolfe, H, Zollner, A, Zumstein, E, Kleine, K, Dujon, B, Albermann, K, Aldea, M, Alexandraki, D, Ansorge, W, Arino, J, Benes, V, Bohn, C, BolotinFukuhara, M, Bordonne, R, Boyer, J, Camasses, A, Casamayor, A, Casas, C, Cheret, G, Cziepluch, C, DaignanFornier, B, Dang, V, deHaan, M, Delius, H, Durand, P, Fairhead, C, Feldmann, H, Gaillon, L, Galisson, F, Gamo, J, Gancedo, C, Goffeau, A, Goulding, E, Grivell, A, Habbig, B, Hand, J, Hani, J, Hattenhorst, U, Hebling, U, Hernando, Y, Herrero, E, Heumann, K, Hiesel, R, Hilger, F, Hofmann, B, Hollenberg, P, Hughes, B, Jauniaux, C, Kalogeropoulos, A, Katsoulou, C, Kordes, E, Lafuente, J, Landt, O, Louis, J, Maarse, C, Madania, A, Mannhaupt, G, Marck, C, Martin, P, Mewes, W, Michaux, G, Paces, V, ParleMcDermott, G, Pearson, M, Perrin, A, Pettersson, B, Poch, O, Pohl, M, Poirey, R, Portetelle, D, Pujol, A, Purnelle, B, Rad, R, Rechmann, S, Schwager, C, Schweizer, M, Sor, F, Sterky, Fredrik, Tarassov, A, Teodoru, C, Tettelin, H, Thierry, A, Tobiasch, E, Tzermia, M, Uhlen, Mathias, Unseld, M, Valens, M, Vandenbol, M, Vetter, I, Vicek, C, Voet, M, Volckaert, G, Voss, H, Wambutt, R, Wedler, H, Wiemann, S, Winsor, B, Wolfe, H, Zollner, A, Zumstein, E, and Kleine, K

Abstract

Chromosome XV was one of the last two chromosomes of Saccharomyces cerevisiae to be discovered(1). It is the third-largest yeast chromosome after chromosomes XII and IV, and is very similar in size to chromosome VII. It alone represents 9% of the yeast genome (8% if ribosomal DNA is included). When systematic sequencing of chromosome XV was started, 93 genes or markers were identified, and most of them were mapped(2). However, very little else was known about chromosome XV which, in contrast to shorter chromosomes, had not been the object of comprehensive genetic or molecular analysis. It was therefore decided to start sequencing chromosome XV only in the third phase of the European Yeast Genome Sequencing Programme, after experience was gained on chromosomes III, XI and II (refs 3-5). The sequence of chromosome XV has been determined from a set of partly overlapping cosmid clones derived from a unique yeast strain, and physically mapped at 3.3-kilobase resolution before sequencing. As well as numerous new open reading frames (ORFs) and genes encoding tRNA or small RNA molecules, the sequence of 1,091,283 base pairs confirms the high proportion of orphan genes and reveals a number of ancestral and successive duplications with other yeast chromosomes., QC 20100812

Published
1997
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4. NF2 gene in neurofibromatosis type 2 patients.

Author

Zucman-Rossi J, Legoix P, Der Sarkissian H, Cheret G, Sor F, Bernardi A, Cazes L, Giraud S, Ollagnon E, Lenoir G, and Thomas G

Subjects
Cells, Cultured, DNA chemistry, DNA genetics, Exons, Gene Rearrangement, Humans, In Situ Hybridization, Fluorescence, Molecular Sequence Data, Point Mutation, Polymorphism, Genetic, RNA analysis, RNA genetics, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Genes, Neurofibromatosis 2 genetics, Neurofibromatosis 2 genetics
Abstract

Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder that predisposes to nervous system tumors. The schwannomin (also termed merlin) protein encoded by the NF2 gene shows a close relationship to the family of cytoskeleton-to-membrane proteins linkers ERM (ezrin-radixin-moesin proteins). Even though penetrance of the disease is >95% and no genetic heterogeneity has been described, point mutations in the NF2 gene have been observed in only 34-66% of the screened NF2 patients, depending on the series. In order to generate tools that would enable an exhaustive alteration screening for the NF2 gene, we have deduced its entire genomic sequence. This knowledge has provided the delineation of a mutation screening strategy which, when applied to a series of 19 NF2 patients, has revealed a high recurrence of large deletions in the gene and has raised the efficiency of mutation detection in NF2 patients to 84% of the cases in this series. The remaining three patients who express two functional NF2 alleles are all sporadic cases, an observation compatible with the presence of mosaicism for NF2 mutation.

Published
1998
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5. A circular plasmid from the yeast Torulaspora delbrueckii.

Author

Blaisonneau J, Sor F, Cheret G, Yarrow D, and Fukuhara H

Subjects
Base Sequence, Cloning, Molecular, DNA Replication, Gene Frequency, Genetic Vectors, Molecular Sequence Data, Ascomycota genetics, DNA, Fungal, Plasmids
Abstract

A new member of the 2-micron family of plasmids, named pTD1, was found in the yeast Torulaspora delbrueckii, a widespread yeast associated with food. Nucleotide sequences revealed the presence of a pair of inverted repeats and three open reading frames, one of which is a homologue of the FLP recombinase gene of 2-micron plasmid. An ARS region was identified, by replication in Saccharomyces cerevisiae and T. delbrueckii, near one of the inverted repeats. By the use of pTD1 derivatives and auxotrophic mutant hosts an efficient host-vector system was established for T. delbrueckii. So far, the 2-micron family of plasmids is restricted to four closely related genera (Q6 group): Saccharomyces, Zygosaccharomyces, Kluyveromyces, and Torulaspora. After a survey of 2500 strains belonging to about 500 species (80 genera) of yeast, no circular plasmids were found in other genera.

Published
1997
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