1. Weight as Predictors of Clinical Progression and Treatment Failure
- Author
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Azar, Kariminia, Nicolas, Durier, Gonzague, Jourdain, Suneeta, Saghayam, Chau V, Do, Lam Van, Nguyen, Rawiwan, Hansudewechakul, Pagakrong, Lumbiganon, Kulkanya, Chokephaibulkit, Khanh Huu, Truong, Virat, Sirisanthana, Vibol, Ung, Saphonn, Vonthanak, Jintanat, Ananworanich, Nik Khairulddin, Nik Yusoff, Nia, Kurniati, Kamarul, Azahar Razali, Moy Siew, Fong, Revathy, Nallusamy, Dewi Kumara, Wati, and M G, Law
- Subjects
Male ,Cart ,medicine.medical_specialty ,Pediatrics ,Asia ,Adolescent ,Pediatric hiv ,Anti-HIV Agents ,MEDLINE ,HIV Infections ,Kaplan-Meier Estimate ,Article ,Treatment failure ,Cohort Studies ,disease progression ,medicine ,Humans ,Pharmacology (medical) ,Treatment Failure ,Child ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Body Weight ,HIV ,cohort ,Viral Load ,z score ,Body Height ,CD4 Lymphocyte Count ,Surgery ,pediatric ,Infectious Diseases ,Child, Preschool ,Disease Progression ,HIV-1 ,Female ,business ,Viral load ,Clinical progression ,Cohort study - Abstract
Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score, 23 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P
- Published
- 2014