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Abstract Background A stent with characteristics of a hybrid design may have advantages in improving the patency of symptomatic iliofemoral vein obstruction. This study assessed the safety and effectiveness of the V-Mixtent Venous Stent in treating symptomatic iliofemoral outflow obstruction. Methods Eligible patients had a Clinical-Etiologic-Anatomic-Physiologic (CEAP) C classification of ≥ 3 or a Venous Clinical Severity Score (VCSS) pain score of ≥ 2. The primary safety endpoint was the rate of major adverse events within 30 days. The primary effectiveness endpoint was the 12-month primary patency rate. Secondary endpoints included changes in VCSS from baseline to 6 and 12 months, alterations in CEAP C classification, Chronic Venous Disease Quality of Life Questionnaire (CIVIQ-14) scores at 12 months, and stent durability measures. Results Between December 2020 and November 2021, 171 patients were enrolled across 15 institutions. A total of 185 endovenous stents were placed, with 91.81% of subjects receiving one stent and 8.19% receiving 2 stents. Within 30 days, only two major adverse events occurred (1.17%; 95% confidence interval [CI], 0.14–4.16%), below the literature-defined performance goal of 11% (P

Objective To investigate the factors influencing interbody cage subsidence after stand-alone oblique lumbar interbody fusion (OLIF). Methods A total of 65 patients (72 lumbar vertebrae) who underwent OLIF in our hospital from Ja-nuary 2019 to January 2023 were selected and divided into subsidence group (n=19) and non-subsidence group (n=53) according to the loss of disc height. The clinical data of the two groups were collected and compared, including gender, age, body mass index, number of lumbar vertebrae requiring surgery, responsible vertebral endplate sclerosis, cage height and length, preoperative CT values of the responsible vertebral body and its upper and lower endplates, preoperative multifidus muscle cross-sectional area at responsible vertebral body, degree of multifidus muscle atrophy, and degree of preoperative articular process degeneration. Logistic regression analysis was used to explore the factors influencing cage subsidence. Results There were significant differences between the two groups in the preoperative CT values of responsible vertebral body and its upper endplate, the proportion of patients with preoperative responsible vertebral body endplate sclerosis, the preoperative multifidus muscle cross-sectional area at responsible vertebral body, the proportion of patients with preoperative severe atrophy of the multifidus muscle, the proportion of patients with cage height 14 mm, the proportion of patients with cage length 55 mm, and the proportion of patients with articular process degeneration of degree 3 (t=2.332-3.097,χ2=4.545-6.246,P

Complicated terrains, specific regions, and high wind turbulence intensity frequently trigger shutdown protection of wind turbines due to vibration beyond the designated limit, resulting in serious loss of power generation. This paper aims at reducing the frequency of shutdowns and improving operational stability of wind turbines. Operational characteristics of wind turbines under complicated conditions such as specific regions and strong turbulent wind were analyzed. A fuzzy control approach was proposed based on pertinent theory, to deal with complicated operating conditions at specific sites. This strategy incorporates a vibration recognition algorithm to classify vibration conditions and a fuzzy control algorithm for vibration suppression based on the categorized conditions. Compared with the conventional shutdown or sector-based control methods, the proposed fuzzy control strategy of vibration suppression eliminates the frequent starting and stopping of wind turbines, thus ensuring power generation and improving operational stability. Furthermore, a simulation analysis was performed using Bladed software, taking 3.x MW wind turbines as the research object. Subsequent experimental verification was carried out at a wind farm. In the experiment, the application of the fuzzy vibration suppression control method effectively led to the quick ride-through of the wind turbine amid the complicated operating conditions including the specific region and strong turbulent wind. A 23.87% reduction in the maximum RMS of the front and rear accelerations of the nacelle demonstrated a substantial enhancement in the wind turbine reliability.

For the low parameter tuning efficiency, accuracy and adaptability of the traditional PID parameter tuning method currently adopted in the wind turbine variable-pitch system, this paper presents a method for self-optimization of wind turbine variable-pitch control parameters based on adaptive genetic algorithm, including variable-gain variable-pitch PID parameter self-optimization and tower damping parameter self-optimization. The author first described the basic principle of variable-pitch control system; then based on the genetic algorithm, planned and designed constraint conditions for different wind turbine models, covering initial population selection, self-optimization algorithm constraints and adaptability function design; and finally compared and analyzed the response curve, simulation and field operation results of the traditional parameter tuning method and self-optimization parameter tuning method. The results show that, compared with the traditional parameter tuning method, the self-optimization parameter tuning method reduces the motor speed fluctuation by about 10%, and the fatigue My load of the tower bottom by about 2%. This shows the self-optimization parameter tuning method can improve the tuning efficiency, accuracy and adaptability.

Introduction Mild cognitive impairment (MCI) is an important intervenable stage for the prevention of dementia. Hypertension is associated with impaired cognition, and when combined with MCI, it may lead to a poor prognosis. Digital computerised cognitive training (CCT) has recently become a potential instrument for improving cognition, but evidence for its efficacy remains limited. This study aims to evaluate the efficacy of a digital adaptive CCT intervention in older patients with hypertension and MCI.Methods and analysis The multicentre, double-blinded, randomised, actively -controlled clinical trial will recruit 200 older (≥60 years) patients with hypertension and MCI from 11 hospitals across China. Participants will be randomly assigned in a 1:1 ratio to the intervention group (multidomain adaptative CCT) and active control group (non-adaptive cognitive training) for 12-week cognitive training for 30 min/day and 5 days/week. Those who have completed their 12-week training in the intervention group will be rerandomised into the continuation and discontinuation training groups. All participants will be followed up to 24 weeks. Neuropsychological assessments and structural and functional 7.0 T MRI will be obtained at baseline and at 12-week and 24-week follow-up. The primary outcome is the possible improvement of global cognitive function at 12 weeks, as measured by the Basic Cognitive Aptitude Tests. Secondary and exploratory endpoints include the major cognitive domain function improvement, self-efficacy, mental health, quality of life and MRI measurements of the brain.Ethics and dissemination The trial has been approved by the institutional review board of Beijing Anzhen Hospital and thereafter by all other participating centres. Trial findings will be disseminated in peer-reviewed journals and conference presentations.Trial registration number NCT05704270.

Abstract Background and aims The increasing prevalence of metabolic and cardiovascular diseases poses a significant challenge to global healthcare systems. Regular physical activity (PA) is recognized for its positive impact on cardiovascular risk factors. This study aimed to investigate the relationship between moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB), and abdominal aortic calcification (AAC) using data from the National Health and Nutrition Examination Survey (NHANES). Methods The study used data from NHANES participants aged 40 and above during the 2013–2014 cycle. AAC scores were assessed using the Kauppila scoring system, and MVPA and SB were self-reported. Sociodemographic variables were considered, and multivariable linear regression models were used to analyze associations between MVPA, SB, and AAC scores. Subgroup analyses were conducted based on age, sex, BMI, hypertension, and diabetes. Results The study included 2843 participants. AAC prevalence was higher in older age groups, smokers, and those with diabetes or hypertension. Lower socioeconomic status was associated with higher AAC prevalence. Individuals engaged in any level of MVPA exhibited lower AAC rates compared to inactive individuals. Not engaging in occupational MVPA (β = 0.46, 95% confidence interval = 0.24‒0.67, p

Background and aims: Thromboangiitis obliterans (TAO), also known as Buerger’s disease, is a rare vasculitis. Observational epidemiology studies have suggested a relationship between the gut microbiota and TAO. However, due to confounding factors and reverse causality, the causal relationship remains unclear. Based on the assumption of their association, this study sought specific gut microbiota causally linked to TAO. Methods: The case–control study was conducted at the Xiangya Hospital of Central South University from November 2022 to January 2023 including twelve TAO patients and nine healthy controls. We conducted a Mendelian randomization (MR) study using summary statistics from a genome-wide association study (GWAS) of gut microbiota and TAO. Considering the scale and accessibility of the data, the MiBioGen consortium served as the exposure, whereas the FinnGen consortium GWAS study served as the outcome. Finally, we compared the results of the MR with those of the case–control studies. Results: The inverse variance weighted (IVW) (OR = 0.119, 95% CI: 0.021–0.688, p = 0.017) and maximum likelihood (ML) (OR = 0.121, 95% CI: 0.020–0.742, p = 0.022) estimates suggest that Ruminiclostridium 5 has a suggestive protective effect on TAO while the IVW (OR = 5.383, 95% CI: 1.128–25.693, p = 0.035) and ML (OR = 5.658, 95% CI: 1.142–28.021, p = 0.034) estimates suggest that Eubacterium (xylanophilum group) has a suggestive risk effect on TAO, and the ML (OR = 0.055, 95% CI: 0.004–0.755, p = 0.030) estimates suggest that Lachnospira has a suggestive protective effect on TAO. No significant heterogeneity of instrumental variables or horizontal pleiotropy was found. The results of the case–control study showed that the TAO had a lower relative abundance of Ruminiclostridium 5 (p = 0.015) and Lachnospira (p = 0.048), and a higher relative abundance of Eubacterium (xylanophilum group) (p = 0.029) than the healthy controls. These results were consistent with the MR analysis. Conclusions: Our study demonstrates that Ruminiclostridium 5, Lachnospira, and Eubacterium (xylanophilum group) are causally related to TAO, suggesting their potential significance for the prevention and treatment of TAO.

BackgroundRupture of abdominal aortic aneurysm (rAAA) is a fatal event in the elderly. Elevated blood pressure and weakening of vessel wall strength are major risk factors for this devastating event. This present study examined whether the expression profile of mechanosensitive genes correlates with the phenotype and outcome, thus, serving as a biomarker for AAA development.MethodsIn this study, we identified mechanosensitive genes involved in AAA development using general bioinformatics methods and machine learning with six human datasets publicly available from the GEO database. Differentially expressed mechanosensitive genes (DEMGs) in AAAs were identified by differential expression analysis. Molecular biological functions of genes were explored using functional clustering, Protein-protein interaction (PPI), and weighted gene co-expression network analysis (WGCNA). According to the datasets (GSE98278, GSE205071 and GSE165470), the changes of diameter and aortic wall strength of AAA induced by DEMGs were verified by consensus clustering analysis, machine learning models, and statistical analysis. In addition, a model for identifying AAA subtypes was built using machine learning methods.Results38 DEMGs clustered in pathways regulating 'Smooth muscle cell biology' and 'Cell or Tissue connectivity'. By analyzing the GSE205071 and GSE165470 datasets, DEMGs were found to respond to differences in aneurysm diameter and vessel wall strength. Thus, in the merged datasets, we formally created subgroups of AAAs and found differences in immune characteristics between the subgroups. Finally, a model that accurately predicts the AAA subtype that is more likely to rupture was successfully developed.ConclusionWe identified 38 DEMGs that may be involved in AAA. This gene cluster is involved in regulating the maximum vessel diameter, degree of immunoinflammatory infiltration, and strength of the local vessel wall in AAA. The prognostic model we developed can accurately identify the AAA subtypes that tend to rupture.

High-frequency chest wall oscillation (HFCWO) therapy is one of the techniques to facilitate the draining of a patient’s lung secretion in pathological situations, and smart therapy with HFCWO devices equipped with multiple actuators can be achieved via locating nidi in the lung. In this paper, through developing a novel acoustic lung spatial model and utilizing acoustic imaging simulation, a new and effective method for assessing lung function with acoustic imaging is presented, which links acoustic lung images with pathologic changes. The structural similarity between the acoustic reference image based on actual lung sound and our model acoustic image based on the airway impedance was achieved by an index of 0.8987, with 1 as the exact score. Simulation studies based on the model are used to analyze the practicality and the extreme design of the acoustic imaging system on the resolution of the located nidus. For instance, a practical system design with sensor numbers between 4 and 35 may recognize a lower resolution nidus length of 73 mm to a better resolution nidus length of 22 mm. On the other hand, an extreme system design with more than 1000 sensors can recognize greater nidus resolution at under 10 mm. Additionally, this research may be utilized to offer recommendations for acoustic imaging system design and assess the number of sensors and sensing diameter in current acoustic imaging systems. Furthermore, the geographic detection of nidus length allows for analyzing of HFCWO therapy results.

BackgroundSpontaneous echo contrast (SEC) observed in transesophageal echocardiography (TEE) is a reliable predictor of the risk of future ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). Left atrial strain globally reflects atrial function, remodeling and distensibility. The left atrial appendage (LAA) is a myogenic remnant of the left atrium, which can actively relax and contract. The left atrial appendage (LAA) is an important part of releasing the pressure of the left atrium. The key role of the left atrium is to regulate the left ventricular filling pressure, act as a reservoir for pulmonary venous return during ventricular contraction, and act as a conduit, transferring blood to the Left ventricle during early ventricular diastole. The purpose of this study was to explore the relationship between left atrial function and left atrial appendage spontaneous echo contrast (LAASEC).MethodsA retrospective study of 338 patients with non-valvular AF was conducted. Two-dimensional speckle-tracking echocardiography provided the following metrics of LA strain: LA strain during the reservoir phase (LASr), LA strain during the conduit phase (LAScd). LA or LAA has the dense SEC of more than grade 3, which is defined as mud like change or pre thrombosis.ResultsPatients with level 3 SEC (n = 81) has lower LASr than those with lower grades of SEC (n = 257) (7.20 ± 3.70 vs. 17.48 ± 8.67, P 2 scores with sensitivity and specificity were 79% and 85%.ConclusionLower LASr is independently associated with the dense LAASEC in NVAF and has incremental values superior to clinical scores. The decrease of LASr may be a potential non-invasive parameter for evaluating the higher risk of LAA thrombosis.

PurposeTo review the association between central obesity and abdominal aortic aneurysm (AAA).Materials and methodsThe PubMed, Web of Sciences, Embase, The China national knowledge infrastructure (CNKI), and Cochrane Library were searched up to April 30, 2022. Researches includes investigation of the relationship between central obesity markers and AAA. Included studies must use recognized measures of central obesity, i.e., waist circumference (WC) and waist-to-hip ratio (WHR), or use imaging techniques to calculate abdominal fat distribution, such as computed tomography (CT) imaging.ResultsEleven clinical researches were identified of which eight discussed the association between physical examination and AAA, and three studies mainly focused on abdominal fat volume (AFV). Seven researches concluded that there was a positive correlation between markers of central obesity and AAA. Three studies found no significant link between markers of central obesity and AAA. One of the remaining studies reported different results for each sex. Three studies pooled in a meta-analysis identified correlation between central obesity and AAA presence (RR = 1.29; 95% confidence interval, 1.14–1.46).ConclusionCentral obesity plays a role in the risk of AAA. Standardized central obesity markers may be predictors of AAA. However, there was no association between abdominal fat volume and AAA. Additional relevant evidence and specific mechanisms warrant further study.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?IDCRD42022332519, identifier CRD42022332519.

PurposeThis study aimed to investigate the effect of exercise intervention, and analyze exercise intervention strategies for adolescent depression through a meta-analysis of RCTs.MethodsAccordance to PRISMA guidelines, PubMed, Medline, EBSCO, Web of Science, SPORTDiscus, PsycINFO, ProQuest, and CNKI were searched for eligible records. Peer-reviewed studies were included if they met the following criteria: population (mean age of 10–18 years), intervention (physical activity, sport, or exercise), and outcomes (depression, adherence, ITT, dropout, adverse events, follow-up report). The protocol of this systematic review was registered in PROSPERO (CRD42022321683). Effect sizes calculations and methodological quality of exercise intervention (TESTEX scale) were carried out. The certainty of evidence was assessed by GRADE framework.ResultsThirteen randomized controlled trials were eligible for this review, which comprised a total of 433 adolescents. Compared with the control treatment, the effect of exercise on adolescent depression was moderate (SMD = −0.65, 95%CI: −1.03 to −0.27, p < 0.01). Heterogeneity was substantial (T2 = 0.30, I2 = 67%, p < 0.01). The moderating effect analysis showed that exercise intervention characteristics (organization form, exercise frequency, exercise intensity, exercise type, and single exercise session duration) of included studies varied greatly revealing multiple factors that may impact the antidepressant effect of exercise on adolescent depression (I2 > 50%, p < 0.05). Three studies show that the positive effect of exercise on reducing depression in adolescents remained 40 weeks after the intervention. Moreover, owing to the included studies contained methodological limitations, the certainty of evidence was reduced to moderate level.ConclusionThis study shows that exercise intervention has a moderate and sustained positive effect on adolescent depression. Our results recommended that adolescents with depression undertake moderate to high intensity group mixed exercise for more than 12 weeks, 20 to 60 min/time, more than 3 times/week. Additionally, our study also shows that the antidepressant effects remained for a long time after the end of exercise interventions. However, following the GRADE framework, we rated the certainty of evidence the primary meta-analysis as moderate evidence due to some limitations of included studies. Therefore, rigorous studies are still needed to verify the results.Systematic review registration[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=321683], identifier [CRD42022321683].

Abstract Background Three-dimensional electroanatomic mapping systems have demonstrated a significant reduction in radiation exposure during radiofrequency catheter ablation procedures. We aimed to investigate the safety, feasibility and efficacy of a completely zero-fluoroscopy approach for catheter ablation of supraventricular tachycardia using the Ensite NavX navigation system compared with a conventional fluoroscopy approach. Methods A multicenter prospective non-randomized registry study was performed in seven centers from January 2013 to February 2018. Consecutive patients referred for catheter ablation of supraventricular tachycardia were assigned either to a completely zero-fluoroscopic approach (ZF) or conventional fluoroscopy approach (CF) according to the operator’s preference. Patients with atrial tachycardia were excluded. Results Totally, 1020 patients were enrolled in ZF group; 2040 patients ablated by CF approach were selected for controls. There was no significant difference between the zero-fluoroscopy group and conventional fluoroscopy group as to procedure time (60.3 ± 20.3 vs. 59.7 ± 22.6 min, P = 0.90), immediate success rate of procedure (98.8% vs. 99.2%, P = 0.22), arrhythmia recurrence (0.4% vs. 0.5%, P = 0.85), total success rate of procedure (98.4% vs. 98.8%, P = 0.39) or complications (1.1% vs. 1.5%, P = 0.41). Compared with the conventional fluoroscopy approach, the zero-fluoroscopy approach provided similar outcomes without compromising the safety or efficacy of the procedure. Conclusion The completely zero-fluoroscopy approach demonstrated safety and efficacy comparable to a conventional fluoroscopy approach for catheter ablation of supraventricular tachycardia, and mitigated radiation exposure to both patients and operators. Trial registration clinicaltrials.gov Identifier: NCT03042078 ; first registered February 3, 2017; retrospectively registered.

Almost all current studies on link prediction problem focus on undirected networks. Unfortunately, many complex networks in the real world are directed. Ignoring the direction of a link will overlook some important information or even make the prediction meaningless. Directly applying the methods for undirected networks to directed networks will reduce the accuracy of prediction. A new method for link prediction in directed networks based on triad patterns was proposed. The proposed metric compare the difference of triad structures between undirected and directed networks and use potential theory to filter the triad patterns. By statistics of triad closeness in various networks, new method calculate the similarity between nodes using the triad closeness index of a network as the weight for different triad patterns. Experiments on nine real networks show that accuracy of proposed method is 4.3% better than benchmark methods.

Objectives: The feasibility of vaginoscopic hysteroscopy combined with office endometrial biopsy after ultrasonography for management of post-menopausal vaginal bleeding (PMB). Materials and methods: A prospective observational study of with PMB whom attending the Outpatient Clinic of Kang Ning Hospital during a four months period (1st Feb to 31st May 2018) was included. Vaginoscopic hysteroscopy was performed with endometrial biopsy after the initial clinical pelvic examination and transvaginal ultrasound examination. Results: A total of 45 consecutive women with PMB was included. The hysteroscopy and endometrial biopsy were successful in 44 out of 45 (98%), a complete view in 82%, adequate tissue was in 91%, only one case was failed both procedures due to pain. The correlation between hysteroscopy and endometrial biopsy by was 100%. The mean operation time was 229 ± 68 s. The most common histological findings was atrophic endometrium 18 (42%). Five endometrial polyps and 2 submucosal leiomyomas were found. One rare case of endometrial carcinosarcoma (2%) was detected. Patients reported less pain for hysteroscopy than endometrial biopsy with rated VAS pain score was 3.5 ± 2.2, with 5 more score in 18%, and for endometrial biopsy 4.2 ± 2 and 33% respectively (p

[Introduction] According to the offshore wind farms layout and typical delivery scheme of Guangdong area, the paper discusses the two joint delivery schemes of 300 MW offshore wind farm. [Method] From the aspects of electrical single line diagram, submarined cable′s selection, reliability analysis, cable laying and supply, comparable investment and so on were compared. [Result] To provide an optimization for the joint delivery of offshore wind farm, setting two 220 kV offshore booster station and one onshore control center, one of the booster station connect to another with one 3×1 000 mm2 submarine cable, then sent out with two 3×1 000 mm2 submarine cable to onshore control center. [Conclusion] The scheme of two joint delivery schemes of 300 MW offshore wind farm can save the investment and reduce the area of sea which offers reference for the prospective electrical design of offshore wind farm.

The stability problem of memristor may affect the performance of memristive neural network. In order to explore it, a memristive back propagation(BP) neural network, in which the memristors are the synapses, is constructed based on the equivalent resistance topology memristor model. And it’s trained and tested on the MNIST dataset. The stability problem of memristor is simulated by setting fluctuations of the parameters in the model. Finally, it is found that the performance fluctuation of the memristor to a certain extent will promote the convergence of the neural network, but the excessive fluctuation will reduce the convergence speed of the network. To characterize this criticality, the maximum fluctuation range of each parameter in the model is obtained. Meanwhile, the fluctuations’ ranges of device parameters are obtained by tracing back to the memristor model. The result provides a reference for the fabrication and selection of memristor devices during hardware application.

This paper introduces a way to realize the supervised neural network algorithms based on memristive characteristics on Field Programmable Gate Array(FPGA) for the problem that how to take the memristors into artificial neural networks and hardware implement. This design uses memristors module as weight store module in neural network to build supervised learning with error feedback mechanism. The memristive neural networks are used in pattern recognition and their hardware resource and processing speed are optimized. Experiment results show that the performance of pattern recognition is quite good. Further, the hardware resource occupancies and training time are 11 773 logic elements(LEs) and 0.33 ms on Cyclone II：EP2C70F896I8, respectively, and the test time of images is 10 μs, which gives a useful reference for combination of memristors and neural networks.

Objective To investigate the expression of circular RNA ciRS-7 in triple-negative breast cancer (TNBC) and its effect on invasion and migration. Methods The expression levels of ciRS-7 in TNBC tissues and cells were detected by qRT-PCR, and its relationship with clinicopathological parameters of breast cancer patients was further analyzed. Scratch and Transwell assays were used to detect the migration and invasion of MDA-MB-231 and BT-549 cells after silencing ciRS-7. Animal experiment was performed to verify the above findings in vivo. Results The relative expression of ciRS-7 in TNBC tissues was (6.52±0.38), significantly higher than Luminal type (1.56±0.17) (P < 0.001), HER2 overexpressing breast cancer tissues (2.27±0.66) (P < 0.001) and normal adjacent tissues (0.83 ± 0.09) (P < 0.001). Clinical data analysis showed that ciRS-7 expression was significantly associated with molecular typing, tumor invasion and lymph node metastasis (all P < 0.05), not associated with patients' age, tumor diameter or pathological grade (all P > 0.05). After silencing ciRS-7, the migration and invasion of MDA-MB-231 and BT-549 cells were significantly reduced (all P < 0.05). The number of lung metastasis clones was significantly reduced in ciRS-7 knockdown group (P < 0.05). Conclusion ciRS-7 is highly expressed in TNBC and may enhance the invasion and migration of TNBC cells.

Objective Anticoagulation management in patients with atrial fibrillation (AF) and impaired renal function is challenging. This study aimed to evaluate anticoagulation prescription patterns in relation to renal function and to describe 2-year clinical outcomes among dabigatran users. Methods Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) is an international, prospective, and observational study program involving patients with newly diagnosed AF at risk for stroke. Prescription patterns were assessed by creatinine clearance (CrCl) at enrollment. Dabigatran users were followed for 2 years. Clinical outcomes were standardized for stroke and bleeding risk, based on CHA2DS2-VASc and HAS-BLED scores, with missing values imputed. Results Baseline CrCl values were available for 12,056 of 15,308 eligible patients (79%). With declining renal function, prescriptions increased for vitamin K antagonists (VKAs) and decreased for dabigatran (30–47% and 34–12%, respectively). The prescription of other non-vitamin K antagonists remained similar across CrCl groups (14–19%). In 4,873 dabigatran users, standardized stroke rates were low across all CrCl groups; 0.58/100 patient-years (95% confidence interval [CI]: 0.30–0.90) in CrCl ≥80 mL/min, 0.85 (95% CI: 0.48–1.21) in CrCl 50 to 79 mL/min, and 0.33 (95% CI: 0.06–1.11) in CrCl 30 to 49 mL/min. Similarly, major bleeding rates were low and numerically increased with declining renal function (0.68/100 patient-years, 95% CI: 0.39–1.03; 0.92, 95% CI: 0.58–1.32; and 1.26, 95% CI: 0.66–1.97, respectively). Conclusion In patients with AF, VKA prescriptions increased and dabigatran prescriptions decreased with declining renal function. Rates of stroke and major bleeding in dabigatran patients remained low across the categories of renal impairment.

Background. There are distinct results for the relationship between new-onset atrial fibrillation (NOAF) and subsequent incident cancer. To date, no systematic analysis has been conducted on this issue. This study aims to explore the relationship between NOAF and the risk of developing cancer through a meta-analysis with a large sample size. Methods. Electronic databases, such as PubMed and EMBASE, were searched for published relevant studies on NOAF patients diagnosed with cancer after and during follow-ups, including reported records of baseline information and the statistical result of morbidity. Two investigators independently reviewed the articles and extracted the data using uniform standards and definitions. The meta-analysis was conducted using the Cochrane Program Review Manager. Results. This meta-analysis consisted of five cohort studies and one case-control study, which comprised 533,514 participants. The pooled relative risk (RR) for incident cancer was 1.24 (95% CI: 1.10–1.39, P=0.0003). The temporal trend analysis demonstrated that an increased risk of cancer was observed during the initial 90 days (RR: 3.44, 95% CI: 2.29–5.57, P

Abstract Since the variation pattern of load during holidays is different than that of non-holidays, forecasting holiday load is a challenging task. With a focus on this problem, we propose a learning framework based on weighted knowledge transfer for daily peak load forecasting during holidays. First, we select source cities which can provide extra hidden knowledge to improve the forecast accuracy of the load of the target city. Then, all the instances which are from source cities and the target city will be weighted and trained by the improved weighted transfer learning algorithm which is based on the TrAdaBoost algorithm and can decrease negative transfer. We evaluate our method with the classical support vector machine method and a method based on knowledge transfer on a real data set, which includes eleven cities from Guangdong province to illustrate the performance of the method. To solve the problem of limited historical holiday load data, we transfer the data from nearby cities based on the fact that nearby cities in Guangdong province have a similar economic development level and similar load variation pattern. The results of comparative experiments show that the forecasting framework proposed by this paper outperforms these methods in terms of mean absolute percent error and mean absolute scaled error.

Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying prognostic significance across studies in DLBCL, and does not provide a comprehensive analysis of macrophage subtypes. Here, using digital spatial profiling with whole transcriptome analysis of CD68+ cells, we characterize macrophages in distinct spatial niches of reactive lymphoid tissues (RLTs) and DLBCL. We reveal transcriptomic differences between macrophages within RLTs (light zone /dark zone, germinal center/ interfollicular), and between disease states (RLTs/ DLBCL), which we then use to generate six spatially-derived macrophage signatures (MacroSigs). We proceed to interrogate these MacroSigs in macrophage and DLBCL single-cell RNA-sequencing datasets, and in gene-expression data from multiple DLBCL cohorts. We show that specific MacroSigs are associated with cell-of-origin subtypes and overall survival in DLBCL. This study provides a spatially-resolved whole-transcriptome atlas of macrophages in reactive and malignant lymphoid tissues, showing biological and clinical significance.

In view of the severe weather conditions in cold regions, the basic characteristics and braking distance of ice snow covered pavement are analyzed. This paper uses the PreScan/CarSim/Simulink software co-simulation method to test the automatic emergency braking (AEB) system on ice-snow roads. Through the appropriate adjustment of the time to collision (TTC) threshold, the car makes automatic emergency braking on the road with low friction coefficient system can achieve the effect of collision avoidance and injury reduction.

The strength growth of concrete depends on the hydration reaction of cement. Curing temperature and humidity are important conditions to determine the hydration rate of cement. In this paper, rebound method is used to detect the structural strength of pumping commercial concrete in winter construction in Jinhua. The relationship between temperature, rebound value and compressive strength value is analyzed based on the concrete strength detection data. At the same time, some effective measures are put forward to solve the problems in winter construction.

AIMS: The clinical correlates and outcomes of asymptomatic atrial fibrillation (AF) in hospitalized patients are largely unknown. We aimed to investigate the clinical correlates and in-hospital outcomes of asymptomatic AF in hospitalized Chinese patients. METHODS AND RESULTS: We conducted a cross-sectional registry study of inpatients with AF enrolled in the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation Project between February 2015 and December 2019. We investigated the clinical characteristics of asymptomatic AF and the association between the clinical correlates and the in-hospital outcomes of asymptomatic AF. Asymptomatic and symptomatic AF were defined according to the European Heart Rhythm Association score. Asymptomatic patients were more commonly males (56.3%) and had more comorbidities such as hypertension (57.4%), diabetes mellitus (18.6%), peripheral artery disease (PAD; 2.3%), coronary artery disease (55.5%), previous history of stroke/transient ischaemic attack (TIA; 17.9%), and myocardial infarction (MI; 5.4%); however, they had less prevalent heart failure (9.6%) or left ventricular ejection fractions ≤40% (7.3%). Asymptomatic patients were more often hospitalized with a non-AF diagnosis as the main diagnosis and were more commonly first diagnosed with AF (23.9%) and long-standing persistent/permanent AF (17.0%). The independent determinants of asymptomatic presentation were male sex, long-standing persistent AF/permanent AF, previous history of stroke/TIA, MI, PAD, and previous treatment with anti-platelet drugs. The incidence of in-hospital clinical events such as all-cause death, ischaemic stroke/TIA, and acute coronary syndrome (ACS) was higher in asymptomatic patients than in symptomatic patients, and asymptomatic clinical status was an independent risk factor for in-hospital all-cause death, ischaemic stroke/TIA, and ACS. CONCLUSION: Asymptomatic AF is common among hospitalized patients with AF. Asymptomatic clinical status is associated with male sex, comorbidities, and a higher risk of in-hospital outcomes. The adoption of effective management strategies for patients with AF should not be solely based on clinical symptoms.