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1. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Author

Raphael Reher, Allegra T. Aron, Pavla Fajtová, Paolo Stincone, Berenike Wagner, Alicia I. Pérez-Lorente, Chenxi Liu, Ido Y. Ben Shalom, Wout Bittremieux, Mingxun Wang, Kyowon Jeong, Marie L. Matos-Hernandez, Kelsey L. Alexander, Eduardo J. Caro-Diaz, C. Benjamin Naman, J. H. William Scanlan, Phil M. M. Hochban, Wibke E. Diederich, Carlos Molina-Santiago, Diego Romero, Khaled A. Selim, Peter Sass, Heike Brötz-Oesterhelt, Chambers C. Hughes, Pieter C. Dorrestein, Anthony J. O’Donoghue, William H. Gerwick, and Daniel Petras

Subjects
Science
Abstract

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

Published
2022
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2. Imaging of single barium atoms in a second matrix site in solid xenon for barium tagging in a $^{136}$Xe double beta decay experiment

Author

Yvaine, M., Fairbank, D., Soderstrom, J., Taylor, C., Stanley, J., Walton, T., Chambers, C., Iverson, A., Fairbank, W., Kharusi, S. Al, Amy, A., Angelico, E., Anker, A., Arnquist, I. J., Atencio, A., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cesmecioglu, D., Chambers, E., Chana, B., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Hein, E., Holt, J. D., Hoppe, E. W., Karelin, A., Keblbeck, D., Kotov, I., Kuchenkov, A., Kumar, K. S., Kwiatkowski, A. A., Larson, A., Latif, M. B., Leach, K. G., Lennarz, A., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Masbou, J., McMichael, K., Peregrina, M. Medina, Moe, M., Mong, B., Moore, D. C., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Pocar, A., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rescia, S., Richardson, G., Ross, R., Rowson, P. C., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Si, L., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., van Bruggen, E., Vidal, M., Walent, M., Wamba, K., Wang, H. W., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Xu, H., Yang, L., Yu, M., and Zeldovich, O.

Subjects
Physics - Atomic Physics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Neutrinoless double beta decay is one of the most sensitive probes for new physics beyond the Standard Model of particle physics. One of the isotopes under investigation is $^{136}$Xe, which would double beta decay into $^{136}$Ba. Detecting the single $^{136}$Ba daughter provides a sort of ultimate tool in the discrimination against backgrounds. Previous work demonstrated the ability to perform single atom imaging of Ba atoms in a single-vacancy site of a solid xenon matrix. In this paper, the effort to identify signal from individual barium atoms is extended to Ba atoms in a hexa-vacancy site in the matrix and is achieved despite increased photobleaching in this site. Abrupt fluorescence turn-off of a single Ba atom is also observed. Significant recovery of fluorescence signal lost through photobleaching is demonstrated upon annealing of Ba deposits in the Xe ice. Following annealing, it is observed that Ba atoms in the hexa-vacancy site exhibit antibleaching while Ba atoms in the tetra-vacancy site exhibit bleaching. This may be evidence for a matrix site transfer upon laser excitation. Our findings offer a path of continued research toward tagging of Ba daughters in all significant sites in solid xenon., Comment: 9 pages, 8 figures

Published
2024

3. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Author

Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, and Jason M. Rohde

Subjects
Chemistry, QD1-999
Published
2018
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4. An integrated online radioassay data storage and analytics tool for nEXO

Author

Tsang, R. H. M., Piepke, A., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, C., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Cohen, J. R., Collister, R., Cvitan, M., Dalmasson, J., Darroch, L., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Echevers, J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Jamil, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., Massacret, N., McMichael, K., Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Peltz-Smalley, H., Perna, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rebeiro, B., Rescia, S., Retière, F., Richardson, G., Ringuette, J., Riot, V., Rowson, P. C., Roy, N., Rudolph, L., Saldanha, R., Sangiorgio, S., Schwartz, S., Soderstrom, J., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Barakoohi, E. Teimoori, Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., Underwood, R., van Bruggen, E., Veeraraghavan, V., Vidal, M., Viel, S., Walent, M., Wamba, K., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, S., Wu, X. M., Yang, H., Yang, L., Yvaine, M., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

Large-scale low-background detectors are increasingly used in rare-event searches as experimental collaborations push for enhanced sensitivity. However, building such detectors, in practice, creates an abundance of radioassay data especially during the conceptual phase of an experiment when hundreds of materials are screened for radiopurity. A tool is needed to manage and make use of the radioassay screening data to quantitatively assess detector design options. We have developed a Materials Database Application for the nEXO experiment to serve this purpose. This paper describes this database, explains how it functions, and discusses how it streamlines the design of the experiment.

Published
2023

5. Generative Adversarial Networks for Scintillation Signal Simulation in EXO-200

Author

Li, S., Ostrovskiy, I., Li, Z., Yang, L., Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., and Tsang, R.

Subjects
High Energy Physics - Experiment, Computer Science - Machine Learning, Physics - Instrumentation and Detectors
Abstract

Generative Adversarial Networks trained on samples of simulated or actual events have been proposed as a way of generating large simulated datasets at a reduced computational cost. In this work, a novel approach to perform the simulation of photodetector signals from the time projection chamber of the EXO-200 experiment is demonstrated. The method is based on a Wasserstein Generative Adversarial Network - a deep learning technique allowing for implicit non-parametric estimation of the population distribution for a given set of objects. Our network is trained on real calibration data using raw scintillation waveforms as input. We find that it is able to produce high-quality simulated waveforms an order of magnitude faster than the traditional simulation approach and, importantly, generalize from the training sample and discern salient high-level features of the data. In particular, the network correctly deduces position dependency of scintillation light response in the detector and correctly recognizes dead photodetector channels. The network output is then integrated into the EXO-200 analysis framework to show that the standard EXO-200 reconstruction routine processes the simulated waveforms to produce energy distributions comparable to that of real waveforms. Finally, the remaining discrepancies and potential ways to improve the approach further are highlighted., Comment: As accepted by JINST

Published
2023
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6. 'Searching for a needle in a haystack;' A Ba-tagging approach for an upgraded nEXO experiment

Author

Rasiwala, H., Murray, K., Lan, Y., Chambers, C., Cvitan, M., Brunner, T., Collister, R., Daniels, T., Elmansali, R., Fairbank, W., Gornea, R., Gratta, G., Koffas, T., Kwiatkowski, A. A., Leach, K. G., Lennarz, A., Malbrunot, C., Ray, D., Shaikh, R., and Yang, L.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

nEXO is a proposed experiment that will search for neutrinoless double-beta decay (0$\nu\beta\beta$) in 5-tonnes of liquid xenon (LXe), isotopically enriched in $^{136}$Xe. A technique called Ba-tagging is being developed as a potential future upgrade for nEXO to detect the $^{136}$Xe double-beta decay daughter isotope, $^{136}$Ba. An efficient Ba-tagging technique has the potential to boost nEXO's 0$\nu\beta\beta$ sensitivity by essentially suppressing non-double-beta decay background events. A conceptual approach for the extraction from the detector volume, trapping, and identification of a single Ba ion from 5 tonnes of LXe is presented, along with initial results from the commissioning of one of its subsystems, a quadrupole mass filter., Comment: 4 pages, 2 figures

Published
2023
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7. Search for Two-neutrino Double-Beta Decay of $^{136}\rm Xe$ to the $0^+_1$ excited state of $^{136}\rm Ba$ with the Complete EXO-200 Dataset

Author

Collaboration, EXO-200, Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A new search for two-neutrino double-beta ($2\nu\beta\beta$) decay of $^{136}\rm Xe$ to the $0^+_1$ excited state of $^{136}\rm Ba$ is performed with the full EXO-200 dataset. A deep learning-based convolutional neural network is used to discriminate signal from background events. Signal detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of two. With the addition of the Phase II dataset taken with an upgraded detector, the median 90$\%$ confidence level half-life sensitivity of $2\nu\beta\beta$ decay to the $0^+_1$ state of $^{136}\rm Ba$ is $2.9 \times 10^{24}~\rm yr$ using a total $^{136}\rm Xe$ exposure of $234.1~\rm kg~yr$. No statistically significant evidence for $2\nu\beta\beta$ decay to the $0^+_1$ state is observed, leading to a lower limit of $T^{2\nu}_{1/2}(0^+ \rightarrow 0^+_1) > 1.4\times10^{24}~\rm yr$ at 90$\%$ confidence level, improved by 70$\%$ relative to the current world's best constraint., Comment: 9 pages, 7 figures, 2 tables

Published
2023
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8. Initiation of a multidisciplinary summer studentship in palliative and supportive care in oncology

Author

Fairchild A, Watanabe S, Chambers C, Yurick J, Lem L, and Tachynski P

Subjects
Medicine (General), R5-920
Abstract

Alysa Fairchild,1 Sharon Watanabe,1 Carole Chambers,2 Janice Yurick,3 Lisa Lem,4 Patty Tachynski51Faculty of Medicine and Dentistry, University of Alberta, Edmonton, 2Department of Pharmacy, Alberta Health Services, 3Department of Rehabilitation Medicine, Cross Cancer Institute, Edmonton, 4Department of Respiratory Therapy, Cross Cancer Institute, Edmonton, 5Department of Clinical Nutrition, Cross Cancer Institute, Edmonton, Alberta, CanadaPurpose: The optimal setting for interprofessional education (IPE) for prelicensure health care trainees is unclear, especially in a field as complex and emotionally challenging as oncology. In this article, the authors describe the initiation of the Cross Cancer Institute Multidisciplinary Summer Studentship in Palliative and Supportive Care in Oncology, a 6-week, multidisciplinary team-based clinical placement in supportive care, designed to incorporate features of best practice cooperative learning.Methods: A steering committee established goals, structure, eligibility criteria, application process, funding, and a consensus approach to instruction and evaluation for the IPE program. Studentship components included mandatory and flexible clinical time, an exploratory investigation, discussion groups, and a presentation. Two senior students per iteration were selected from clinical nutrition, medicine, nursing, occupational therapy, pharmacy, physiotherapy, respiratory therapy, social work, and speech–language pathology applicants. These students completed questionnaires investigating their views of their own and others' professions at baseline, at the end of the rotation, and 6 months after the studentship.Results: Eight students from medicine, clinical nutrition, occupational therapy, physiotherapy, and speech–language pathology have participated to date. At the elective's end, students have described a more positive view of multidisciplinary team practice, with each participating discipline perceived as both more caring and more subservient than at baseline. In general, changes in attitudes were maintained 6 months after completion of the placement.Conclusion: This 6-week multidisciplinary placement is feasible, successful, and potentially transferable to other academic settings. The results of this study suggest that even over as short a period as 6 weeks, objective attitudinal and perceptual change is seen.Keywords: interprofessional education, multidisciplinary team, clinical placement, perceptual change, evaluation

Published
2012

9. Parasites, diet and stable isotopes of shorthorn sculpin (Myoxocephalus scorpius) from Frobisher bay, Canada

Author

Dick T., Chambers C., and Gallagher C.P.

Subjects
shorthorn sculpin, Myoxocephalus scorpius, parasites, diet, stable isotopes, Infectious and parasitic diseases, RC109-216
Abstract

Shorthorn sculpin (Myoxocephalus scorpius) from Frobisher Bay, Baffin Island, is a slow growing long-lived species. A wide range of diet items were present in the stomachs of the shorthorn sculpins sampled but 2-3 diet items (amphipod species) comprised 99.5% of total food consumed. These amphipods were present in the stomachs in similar proportions among all age classes of shorthorn sculpin. Several new host records for parasites were reported and mean numbers of parasite species increased with shorthorn sculpin age. The increased diversity of parasite species and higher δ15N values in older/larger individuals suggest that their diets were more diverse and the prey items consumed had higher δ15N values. By contrast, the value of δ13C in dominant diet items masked the δ13C values of minor diet items. We conclude that parasites and stable isotope values provide complementary data on feeding patterns of the shorthorn sculpin. The ubiquitous marine acanthocephalan, Echinorhynchus gadi, was found at high prevalences (87–100%) and mean intensities (28–35), and were localized in the midgut. In contrast to other studies on acanthocephalans, E. gadi did not influence fish condition as measured by condition factor, liver somatic and gonado-somatic indices.

Published
2009
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10. Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO

Author

Gallina, G., Guan, Y., Retiere, F., Cao, G., Bolotnikov, A., Kotov, I., Rescia, S., Soma, A. K., Tsang, T., Darroch, L., Brunner, T., Bolster, J., Cohen, J. R., Franco, T. Pinto, Gillis, W. C., Smalley, H. Peltz, Thibado, S., Pocar, A., Bhat, A., Jamil, A., Moore, D. C., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Arsenault, P., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Brodsky, J. P., Brown, E., Caden, E., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y., Dolinski, M. J., Dragone, A., Echevers, J., Eckert, B., Elbeltagi, M., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gautam, P., Giacomini, G., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., Hößl, J., House, A., Hunt, W., Iverson, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lessard, G., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Margetak, P., Martel-Dion, P., Martin, L., Masbou, J., Massacret, N., McMichael, K., Mong, B., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Parent, S., Perna, A., Piepke, A., Pletskova, N., Pratte, J. F., Radeka, V., Raguzin, E., Ramonnye, G. J., Rao, T., Rasiwala, H., Raymond, K., Rebeiro, B. M., Richardson, G., Ringuette, J., Riot, V., Rossignol, T., Rowson, P. C., Rudolph, L., Saldanha, R., Sangiorgio, S., Shang, X., Spadoni, F., Stekhanov, V., Sun, X. L., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., Vachon, F., Vidal, M., Viel, S., Visser, G., Wagenpfeil, M., Walent, M., Wamba, K., Wang, Q., Wang, W., Wang, Y., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, W. H., Wu, X., Xie, L., Yan, W., Yang, H., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors
Abstract

Liquid xenon time projection chambers are promising detectors to search for neutrinoless double beta decay (0$\nu \beta \beta$), due to their response uniformity, monolithic sensitive volume, scalability to large target masses, and suitability for extremely low background operations. The nEXO collaboration has designed a tonne-scale time projection chamber that aims to search for 0$\nu \beta \beta$ of \ce{^{136}Xe} with projected half-life sensitivity of $1.35\times 10^{28}$~yr. To reach this sensitivity, the design goal for nEXO is $\leq$1\% energy resolution at the decay $Q$-value ($2458.07\pm 0.31$~keV). Reaching this resolution requires the efficient collection of both the ionization and scintillation produced in the detector. The nEXO design employs Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm scintillation light of liquid xenon. This paper reports on the characterization of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3 SiPMs specifically designed for nEXO, as well as new measurements on new test samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters (MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct crosstalk, correlated avalanches and photon detection efficiency were measured as a function of the applied over voltage and wavelength at liquid xenon temperature (163~K). The results from this study are used to provide updated estimates of the achievable energy resolution at the decay $Q$-value for the nEXO design.

Published
2022
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11. Search for MeV Electron Recoils from Dark Matter in EXO-200

Author

Collaboration, EXO-200, Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R. H. M., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present a search for electron-recoil signatures from the charged-current absorption of fermionic dark matter using the EXO-200 detector. We report an average electron recoil background rate of $6.8 \times 10^{-4}\, \mathrm{cts}\,\mathrm{kg}^{-1}\mathrm{yr}^{-1}\mathrm{keV}^{-1}$ above $4\,\mathrm{MeV}$ and find no statistically significant excess over our background projection. Using a total ${}^{136}\mathrm{Xe}$ exposure of $234.1\,\mathrm{kg}\,\mathrm{yr}$ we exclude new parameter space for the charged-current absorption cross-section for dark matter masses between $m_\chi = 2.6\,\mathrm{MeV} - 11.6\,\mathrm{MeV}$ with a minimum of $6\times 10^{-51}\,\mathrm{cm}^2$ at $8.3\,\mathrm{MeV}$ at the $90\%$ confidence level., Comment: 9 pages, 6 figures, 1 table

Published
2022
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12. Search for Majoron-emitting modes of $^{136}$Xe double beta decay with the complete EXO-200 dataset

Author

Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retiere, F., Robinson, A. L., Rowson, P. C., Rudde, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A search for Majoron-emitting modes of the neutrinoless double-beta decay of $^{136}$Xe is performed with the full EXO-200 dataset. This dataset consists of a total $^{136}$Xe exposure of 234.1 kg$\cdot$yr, and includes data with detector upgrades that have improved the energy threshold relative to previous searches. A lower limit of T$_{1/2}^{\rm{^{136}Xe}}>$4.3$\cdot$10$^{24}$ yr at 90\% C.L. on the half-life of the spectral index $n=1$ Majoron decay was obtained, a factor of 3.6 more stringent than the previous limit from EXO-200, corresponding to a constraint on the Majoron-neutrino coupling constant of $|\langle g_{ee}^{M}\rangle|$$<(0.4$-$0.9)\cdot10^{-5}$. The lower threshold and the additional data taken resulted in a factor 8.4 improvement for the $n=7$ mode compared to the previous EXO search. This search provides the most stringent limits to-date on the Majoron-emitting decays of $^{136}$Xe with spectral indices $n=1,2,3,$ and 7.

Published
2021
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13. Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.

Author

Bandoli, G, Kable, J, Coles, C, Del Campo, M, Suttie, M, and Chambers, C

Subjects
Behavioral outcomes, Prenatal alcohol exposure, Trajectory models, Alcohol Drinking, Child, Female, Fetal Alcohol Spectrum Disorders, Humans, Pregnancy, Prenatal Exposure Delayed Effects
Abstract

OBJECTIVE: To characterize patterns of prenatal alcohol exposure (PAE), and determine whether PAE trajectories were associated with behavior from a community-based sample of first-grade children. METHODS: Using data collected as part of the Collaboration of Fetal Alcohol Spectrum Disorders Prevalence study (n = 1663), we performed longitudinal cluster analysis on prenatal alcohol use reported for four time points around conception and pregnancy. From the sample, 638 respondents reported any alcohol use in pregnancy and were included in trajectories for average daily and maximum drinks per drinking day (max DDD). We then estimated the association with behavioral problems measured by the Child Behavior Checklist (CBCL) and Teacher Report Form (TRF) with multivariable linear regression. The reference group had 1025 children with no reported PAE. RESULTS: Five trajectories were selected to describe max DDD patterns: very low/discontinuing (n = 186), low/discontinuing (n = 111), very low/continuing (n = 47), med/high (n = 245), and high (n = 49). Six trajectories best described average daily alcohol use: very low/discontinuing (n = 378), very low/continuing (n = 98), low/continuing (n = 56), low/discontinuing (n = 37), medium/high (n = 35), and high (n = 31). When assessing max DDD trajectories for both the CBCL and TRF, individuals with PAE in the two highest trajectories and the very low/continuing trajectory had more behavioral problems relative to children with no PAE, although confidence intervals for most estimates included the null. PAE modeled as average drinks per day did not predict behavior in any consistent pattern. CONCLUSIONS: In this community-based sample, select PAE trajectories were associated with behavior, even at relatively low levels of PAE that continued later in gestation.

Published
2022

15. Characterization of a Spatially Resolved Multi-Element Laser Ablation Ion Source

Author

Murray, K., Chambers, C., Chen, D., Feng, Z., Fraser, J., Ito, Y., Lan, Y., Mendez, S., Peregrina, M. Medina, Rasiwala, H., Richez, L., Roy, N., Simpson, R., Dilling, J., Fairbank Jr., W., Kwiatkowski, A. A., and Brunner, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

A laser ablation ion source (LAS) is a powerful tool by which diverse species of ions can be produced for mass spectrometer calibration, or surface study applications. It is necessary to frequently shift the laser position on the target to selectively ablate materials in a controlled manner, and to mitigate degradation of the target surface caused by ablation. An alternative to mounting the target onto a rotation wheel or $x-y$ translation stage, is to shift the laser position with a final reflection from a motorized kinematic mirror mount. Such a system has been developed, assembled and characterized with a two axis motorized mirror and various metal targets. In the system presented here, ions are ablated from the target surface and guided by a 90 degree quadrupole bender to a Faraday cup where the ion current is measured. Spatially resolved scans of the target are produced by actuating the mirror motors, thus moving the laser spot across the target, and performing synchronous measurements of the ion current to construct 2D images of a target surface which can be up to 50~mm in diameter. The spatial resolution of the system has been measured by scanning the interfaces between metals such as steel and niobium, where it was demonstrated that the LAS can selectively ablate an area of diameter $\approx$50 $\mu$m. This work informs the development of subsequent LAS systems, that are intended to serve as multi-element ion sources for commercial and custom-built time-of-flight mass spectrometers, or to selectively study surface specific regions of samples.

Published
2021
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16. The EXO-200 detector, part II: Auxiliary Systems

Author

Ackerman, N., Albert, J., Auger, M., Auty, D. J., Badhrees, I., Barbeau, P. S., Bartoszek, L., Baussan, E., Belov, V., Benitez-Medina, C., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Conley, R., Cook, S., Coon, M., Craddock, W., Craycraft, A., Cree, W., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Davis, C. G., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., deVoe, R., Didberidze, T., Dilling, J., Dobi, A., Dolgolenko, A. G., Dolinski, M. J., Dunford, M., Echevers, J., Espic, L., Fairbank Jr., W., Fairbank, D., Farine, J., Feldmeier, W., Feyzbakhsh, S., Fierlinger, P., Fouts, K., Franco, D., Freytag, D., Fudenberg, D., Gautam, P., Giroux, G., Gornea, R., Graham, K., Gratta, G., Hagemann, C., Hall, C., Hall, K., Haller, G., Hansen, E. V., Hargrove, C., Herbst, R., Herrin, S., Hodgson, J., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Johnson, T. N., Johnston, S., Karelin, A., Kaufman, L. J., Killick, R., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Leonard, F., LePort, F., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Mackay, D., MacLellan, R., Marino, M., Martin, J. -M., Martin, Y., McElroy, T., McFarlane, K., Michel, T., Mong, B., Moore, D. C., Murray, K., Neilson, R., Njoya, O., Nusair, O., O'Sullivan, K., Odian, A., Ostrovskiy, I., Ouellet, C., Piepke, A., Pocar, A., Prescott, C. Y., Pushkin, K., Retiere, F., Rivas, A., Robinson, A. L., Rollin, E., Rowson, P. C., Rozo, M. P., Runge, J., Russell, J. J., Schmidt, S., Schubert, A., Sinclair, D., Skarpaas, K., Slutsky, S., Smith, E., Soma, A. K., Stekhanov, V., Strickland, V., Swift, M., Tarka, M., Todd, J., Tolba, T., Tosi, D., Totev, T. I., Tsang, R., Twelker, K., Veenstra, B., Veeraraghavan, V., Vuilleumier, J. -L., Vuilleumier, J. -M., Wagenpfeil, M., Waite, A., Walton, J., Walton, T., Wamba, K., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wittgen, M., Wodin, J., Wood, J., Wrede, G., Wu, S. X., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O. Ya, and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The EXO-200 experiment searched for neutrinoless double-beta decay of $^{136}$Xe with a single-phase liquid xenon detector. It used an active mass of 110 kg of 80.6%-enriched liquid xenon in an ultra-low background time projection chamber with ionization and scintillation detection and readout. This paper describes the design and performance of the various support systems necessary for detector operation, including cryogenics, xenon handling, and controls. Novel features of the system were driven by the need to protect the thin-walled detector chamber containing the liquid xenon, to achieve high chemical purity of the Xe, and to maintain thermal uniformity across the detector., Comment: Manuscript updated in response to JINST reviewer comments

Published
2021
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17. NEXO: Neutrinoless double beta decay search beyond $10^{28}$ year half-life sensitivity

Author

nEXO Collaboration, Adhikari, G., Kharusi, S. Al, Angelico, E., Anton, G., Arnquist, I. J., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Collister, R., Czyz, S. A., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolgolenko, A., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fu, Y. S., Gallina, G., Gautam, P., Giacomini, G., Gingras, W. Gillis C., Goeldi, D., Gornea, R., Gratta, G., Hardy, C. A., Harouaka, K., Heffner, M., Hoppe, E. W., House, A., Iverson, A., Jamil, A., Jewell, M., Jiang, X. S., Karelin, A., Kaufman, L. J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Martel-Dion, P., Masbou, J., Massacret, N., McElroy, T., McMichael, K., Peregrina, M. Medina, Michel, T., Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Newby, R. J., Ni, K., Nolet, F., Nusair, O., Ondze, J. C. Nzobadila, Odgers, K., Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Parent, S., Perna, A., Piepke, A., Pocar, A., Pratte, J-F., Priel, N., Radeka, V., Raguzin, E., Ramonnye, G. J., Rao, T., Rasiwala, H., Rescia, S., Retière, F., Ringuette, J., Riot, V., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Shang, X., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T., Triambak, S., Tsang, R. H. M., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Vivo-Vilches, C., Vogel, P., Vuilleumier, J-L., Wagenpfeil, M., Wager, T., Walent, M., Wamba, K., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yan, W., Yang, H., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The nEXO neutrinoless double beta decay experiment is designed to use a time projection chamber and 5000 kg of isotopically enriched liquid xenon to search for the decay in $^{136}$Xe. Progress in the detector design, paired with higher fidelity in its simulation and an advanced data analysis, based on the one used for the final results of EXO-200, produce a sensitivity prediction that exceeds the half-life of $10^{28}$ years. Specifically, improvements have been made in the understanding of production of scintillation photons and charge as well as of their transport and reconstruction in the detector. The more detailed knowledge of the detector construction has been paired with more assays for trace radioactivity in different materials. In particular, the use of custom electroformed copper is now incorporated in the design, leading to a substantial reduction in backgrounds from the intrinsic radioactivity of detector materials. Furthermore, a number of assumptions from previous sensitivity projections have gained further support from interim work validating the nEXO experiment concept. Together these improvements and updates suggest that the nEXO experiment will reach a half-life sensitivity of $1.35\times 10^{28}$ yr at 90% confidence level in 10 years of data taking, covering the parameter space associated with the inverted neutrino mass ordering, along with a significant portion of the parameter space for the normal ordering scenario, for almost all nuclear matrix elements. The effects of backgrounds deviating from the nominal values used for the projections are also illustrated, concluding that the nEXO design is robust against a number of imperfections of the model., Comment: 26 pages, 19 figures, version accepted by Journal of Phys. G

Published
2021
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18. Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize

Author

Förster, Christiane, Handrick, Vinzenz, Ding, Yezhang, Nakamura, Yoko, Paetz, Christian, Schneider, Bernd, Castro-Falcón, Gabriel, Hughes, Chambers C, Luck, Katrin, Poosapati, Sowmya, Kunert, Grit, Huffaker, Alisa, Gershenzon, Jonathan, Schmelz, Eric A, and Köllner, Tobias G

Subjects
Plant Biology, Biological Sciences, Infectious Diseases, Antifungal Agents, Cytochrome P-450 Enzyme System, Disease Resistance, Flavonoids, Fusarium, Genetic Variation, Genotype, Host-Pathogen Interactions, Methyltransferases, Plant Diseases, Zea mays, Agricultural and Veterinary Sciences, Plant Biology & Botany, Plant biology
Abstract

Fungal infection of grasses, including rice (Oryza sativa), sorghum (Sorghum bicolor), and barley (Hordeum vulgare), induces the formation and accumulation of flavonoid phytoalexins. In maize (Zea mays), however, investigators have emphasized benzoxazinoid and terpenoid phytoalexins, and comparatively little is known about flavonoid induction in response to pathogens. Here, we examined fungus-elicited flavonoid metabolism in maize and identified key biosynthetic enzymes involved in the formation of O-methylflavonoids. The predominant end products were identified as two tautomers of a 2-hydroxynaringenin-derived compound termed xilonenin, which significantly inhibited the growth of two maize pathogens, Fusarium graminearum and Fusarium verticillioides. Among the biosynthetic enzymes identified were two O-methyltransferases (OMTs), flavonoid OMT 2 (FOMT2), and FOMT4, which demonstrated distinct regiospecificity on a broad spectrum of flavonoid classes. In addition, a cytochrome P450 monooxygenase (CYP) in the CYP93G subfamily was found to serve as a flavanone 2-hydroxylase providing the substrate for FOMT2-catalyzed formation of xilonenin. In summary, maize produces a diverse blend of O-methylflavonoids with antifungal activity upon attack by a broad range of fungi.

Published
2022

19. Specialized Metabolite-Mediated Predation Defense in the Marine Actinobacterium Salinispora

Author

Tuttle, Robert N, Rouse, Greg W, Castro-Falcón, Gabriel, Hughes, Chambers C, and Jensen, Paul R

Subjects
Actinobacteria, Animals, Caenorhabditis elegans, Ecosystem, Micromonosporaceae, Predatory Behavior, Salinispora, chemical defense, predation, Microbiology
Abstract

The obligate marine actinobacterial genus Salinispora has become a model organism for natural product discovery, yet little is known about the ecological functions of the compounds produced by this taxon. The aims of this study were to assess the effects of live cultures and culture extracts from two Salinispora species on invertebrate predators. In choice-based feeding experiments using the bacterivorous nematode Caenorhabditis elegans, live cultures of both Salinispora species were less preferred than Escherichia coli. When given a choice between the two species, C. elegans preferred S. areniolca over S. tropica. Culture extracts from S. tropica deterred C. elegans, while those from S. arenicola did not, suggesting that compounds produced by S. tropica account for the feeding deterrence. Bioactivity-guided isolation linked compounds in the lomaiviticin series to the deterrent activity. Additional assays using the marine polychaete Ophryotrocha siberti and marine nematodes further support the deterrent activity of S. tropica against potential predators. These results provide evidence that Salinispora natural products function as a defense against predation and that the strategies of predation defense differ between closely related species. IMPORTANCE Bacteria inhabiting marine sediments are subject to predation by bacterivorous eukaryotes. Here, we test the hypothesis that sediment-derived bacteria in the genus Salinispora produce biologically active natural products that function as a defense against predation. The results reveal that cultures and culture extracts of S. tropica deter feeding by Caenorhabditis elegans and negatively affect the habitat preference of a marine annelid (Ophryotrocha siberti). These activities were linked to the lomaiviticins, a series of cytotoxic compounds produced by S. tropica. Microbial natural products that function as a defense against predation represent a poorly understood trait that can influence community structure in marine sediments.

Published
2022

20. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Author

Reher, Raphael, Aron, Allegra T, Fajtová, Pavla, Stincone, Paolo, Wagner, Berenike, Pérez-Lorente, Alicia I, Liu, Chenxi, Shalom, Ido Y Ben, Bittremieux, Wout, Wang, Mingxun, Jeong, Kyowon, Matos-Hernandez, Marie L, Alexander, Kelsey L, Caro-Diaz, Eduardo J, Naman, C Benjamin, Scanlan, JH William, Hochban, Phil MM, Diederich, Wibke E, Molina-Santiago, Carlos, Romero, Diego, Selim, Khaled A, Sass, Peter, Brötz-Oesterhelt, Heike, Hughes, Chambers C, Dorrestein, Pieter C, O’Donoghue, Anthony J, Gerwick, William H, and Petras, Daniel

Subjects
Medical Biochemistry and Metabolomics, Analytical Chemistry, Biomedical and Clinical Sciences, Chemical Sciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Chromatography, Liquid, Magnetic Resonance Spectroscopy, Metabolomics, Protease Inhibitors, Tandem Mass Spectrometry
Abstract

The identity and biological activity of most metabolites still remain unknown. A bottleneck in the exploration of metabolite structures and pharmaceutical activities is the compound purification needed for bioactivity assignments and downstream structure elucidation. To enable bioactivity-focused compound identification from complex mixtures, we develop a scalable native metabolomics approach that integrates non-targeted liquid chromatography tandem mass spectrometry and detection of protein binding via native mass spectrometry. A native metabolomics screen for protease inhibitors from an environmental cyanobacteria community reveals 30 chymotrypsin-binding cyclodepsipeptides. Guided by the native metabolomics results, we select and purify five of these compounds for full structure elucidation via tandem mass spectrometry, chemical derivatization, and nuclear magnetic resonance spectroscopy as well as evaluation of their biological activities. These results identify rivulariapeptolides as a family of serine protease inhibitors with nanomolar potency, highlighting native metabolomics as a promising approach for drug discovery, chemical ecology, and chemical biology studies.

Published
2022

21. Reflectivity of VUV-sensitive Silicon Photomultipliers in Liquid Xenon

Author

Wagenpfeil, M., Ziegler, T., Schneider, J., Fieguth, A., Murra, M., Schulte, D., Althueser, L., Huhmann, C., Weinheimer, C., Michel, T., Anton, G., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Badhrees, I., Bane, J., Beck, D., Belov, V., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Craycraft, A., Daniels, T., Darroch, L., Der Mesrobian-Kabakian, A., Croix, A. de St, Deslandes, K., DeVoe, R., Di Vacri, M. L., Dolinski, M. J., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Gallina, G., Gautam, P., Giacomini, G., Gingras, C., Goeldi, D., Gorham, A., Gornea, R., Gratta, G., Hansen, E. V., Hardy, C. A., Harouaka, K., Heffner, M., Hoppe, E. W., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Martel-Dion, P., Massacret, N., McElroy, T., Peregrina, M. Medina, Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Newby, R. J., Nolet, F., Nusair, O., Ondze, J. C. Nzobadila, Odgers, K., Odian, A., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Raguzin, E., Ramonnye, G. J., Rasiwala, H., Rescia, S., Retière, F., Richard, C., Richman, M., Ringuette, J., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Soma, A. K., Spadoni, F., Stekhanov, V., Stiegler, T., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T., Triambak, S., Tsang, R., Vachon, F., Veeraraghavan, V., Viel, S., Vivo-Vilches, C., Walent, M., Wichoski, U., Worcester, M., Wu, S. X., Xia, Q., Yan, W., Yang, L., and Zeldovich, O.

Subjects
Physics - Instrumentation and Detectors
Abstract

Silicon photomultipliers are regarded as a very promising technology for next-generation, cutting-edge detectors for low-background experiments in particle physics. This work presents systematic reflectivity studies of Silicon Photomultipliers (SiPM) and other samples in liquid xenon at vacuum ultraviolet (VUV) wavelengths. A dedicated setup at the University of M\"unster has been used that allows to acquire angle-resolved reflection measurements of various samples immersed in liquid xenon with 0.45{\deg} angular resolution. Four samples are investigated in this work: one Hamamatsu VUV4 SiPM, one FBK VUV-HD SiPM, one FBK wafer sample and one Large-Area Avalanche Photodiode (LA-APD) from EXO-200. The reflectivity is determined to be 25-36% at an angle of incidence of 20{\deg} for the four samples and increases to up to 65% at 70{\deg} for the LA-APD and the FBK samples. The Hamamatsu VUV4 SiPM shows a decline with increasing angle of incidence. The reflectivity results will be incorporated in upcoming light response simulations of the nEXO detector., Comment: 18 pages, 11 figures

Published
2021
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22. Search for Majoron-emitting modes of Xe136 double beta decay with the complete EXO-200 dataset

Author

Al Kharusi, S, Anton, G, Badhrees, I, Barbeau, PS, Beck, D, Belov, V, Bhatta, T, Breidenbach, M, Brunner, T, Cao, GF, Cen, WR, Chambers, C, Cleveland, B, Coon, M, Craycraft, A, Daniels, T, Darroch, L, Daugherty, SJ, Davis, J, Delaquis, S, Der Mesrobian-Kabakian, A, DeVoe, R, Dilling, J, Dolgolenko, A, Dolinski, MJ, Echevers, J, Fairbank, W, Fairbank, D, Farine, J, Feyzbakhsh, S, Fierlinger, P, Fudenberg, D, Gautam, P, Gornea, R, Gratta, G, Hall, C, Hansen, EV, Hoessl, J, Hufschmidt, P, Hughes, M, Iverson, A, Jamil, A, Jessiman, C, Jewell, MJ, Johnson, A, Karelin, A, Kaufman, LJ, Koffas, T, Krücken, R, Kuchenkov, A, Kumar, KS, Lan, Y, Larson, A, Lenardo, BG, Leonard, DS, Li, GS, Li, S, Li, Z, Licciardi, C, Lin, YH, MacLellan, R, McElroy, T, Michel, T, Mong, B, Moore, DC, Murray, K, Njoya, O, Nusair, O, Odian, A, Ostrovskiy, I, Perna, A, Piepke, A, Pocar, A, Retière, F, Robinson, AL, Rowson, PC, Ruddell, D, Runge, J, Schmidt, S, Sinclair, D, Skarpaas, K, Soma, AK, Stekhanov, V, Tarka, M, Thibado, S, Todd, J, Tolba, T, Totev, TI, Tsang, R, Veenstra, B, Veeraraghavan, V, Vogel, P, Vuilleumier, J-L, Wagenpfeil, M, Watkins, J, Weber, M, Wen, LJ, Wichoski, U, Wrede, G, and Wu, SX

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

A search for Majoron-emitting modes of the neutrinoless double beta decay of Xe136 is performed with the full EXO-200 dataset. This dataset consists of a total Xe136 exposure of 234.1 kg·yr, and includes data with detector upgrades that have improved the energy threshold relative to previous searches. A lower limit of T1/2Xe136>4.3×1024 yr at 90% C.L. on the half-life of the spectral index n=1 Majoron decay was obtained, a factor of 3.6 more stringent than the previous limit from EXO-200 and a factor of 1.6 more stringent than the previous best limit from KamLAND-Zen. This limit corresponds to a constraint on the Majoron-neutrino coupling constant of |geeM|

Published
2021

23. Event Reconstruction in a Liquid Xenon Time Projection Chamber with an Optically-Open Field Cage

Author

Stiegler, T., Sangiorgio, S., Brodsky, J. P., Heffner, M., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bolotnikov, A., Breur, P. A., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., Deslandes, K., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lv, P., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ni, K., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Sun, X. L., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Worcester, M., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors
Abstract

nEXO is a proposed tonne-scale neutrinoless double beta decay ($0\nu\beta\beta$) experiment using liquid ${}^{136}Xe$ (LXe) in a Time Projection Chamber (TPC) to read out ionization and scintillation signals. Between the field cage and the LXe vessel, a layer of LXe ("skin" LXe) is present, where no ionization signal is collected. Only scintillation photons are detected, owing to the lack of optical barrier around the field cage. In this work, we show that the light originating in the skin LXe region can be used to improve background discrimination by 5% over previous published estimates. This improvement comes from two elements. First, a fraction of the $\gamma$-ray background is removed by identifying light from interactions with an energy deposition in the skin LXe. Second, background from ${}^{222}Rn$ dissolved in the skin LXe can be efficiently rejected by tagging the $\alpha$ decay in the ${}^{214}Bi-{}^{214}Po$ chain in the skin LXe., Comment: 11 pages, 12 figures

Published
2020
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24. Measurement of the Spectral Shape of the beta-decay of 137Xe to the Ground State of 137Cs in EXO-200 and Comparison with Theory

Author

Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Kostensalo, J., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Suhonen, J., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We report on a comparison between the theoretically predicted and experimentally measured spectra of the first-forbidden non-unique $\beta$-decay transition $^{137}\textrm{Xe}(7/2^-)\to\,^{137}\textrm{Cs}(7/2^+)$. The experimental data were acquired by the EXO-200 experiment during a deployment of an AmBe neutron source. The ultra-low background environment of EXO-200, together with dedicated source deployment and analysis procedures, allowed for collection of a pure sample of the decays, with an estimated signal-to-background ratio of more than 99-to-1 in the energy range from 1075 to 4175 keV. In addition to providing a rare and accurate measurement of the first-forbidden non-unique $\beta$-decay shape, this work constitutes a novel test of the calculated electron spectral shapes in the context of the reactor antineutrino anomaly and spectral bump., Comment: Version as accepted by PRL

Published
2020
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25. Reflectance of Silicon Photomultipliers at Vacuum Ultraviolet Wavelengths

Author

Lv, P., Cao, G. F., Wen, L. J., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Mamahit, S. Byrne, Caden, E., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., Deslandes, K., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Doria, L., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Watkins, J., Wei, W., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Characterization of the vacuum ultraviolet (VUV) reflectance of silicon photomultipliers (SiPMs) is important for large-scale SiPM-based photodetector systems. We report the angular dependence of the specular reflectance in a vacuum of SiPMs manufactured by Fondazionc Bruno Kessler (FBK) and Hamamatsu Photonics K.K. (HPK) over wavelengths ranging from 120 nm to 280 nm. Refractive index and extinction coefficient of the thin silicon-dioxide film deposited on the surface of the FBK SiPMs are derived from reflectance data of a FBK silicon wafer with the same deposited oxide film as SiPMs. The diffuse reflectance of SiPMs is also measured at 193 nm. We use the VUV spectral dependence of the optical constants to predict the reflectance of the FBK silicon wafer and FBK SiPMs in liquid xenon.

Published
2019
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26. An integrated online radioassay data storage and analytics tool for nEXO

Author

Tsang, R.H.M., Piepke, A., Al Kharusi, S., Angelico, E., Arnquist, I.J., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E.P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P.A., Brodsky, J.P., Brown, E., Brunner, T., Caden, E., Cao, G.F., Cao, L.Q., Cesmecioglu, D., Chambers, C., Chambers, E., Chana, B., Charlebois, S.A., Chernyak, D., Chiu, M., Cleveland, B., Cohen, J.R., Collister, R., Cvitan, M., Dalmasson, J., Darroch, L., Deslandes, K., DeVoe, R., di Vacri, M.L., Ding, Y.Y., Dolinski, M.J., Echevers, J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fu, Y.S., Gallacher, D., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Guan, Y.D., Hardy, C.A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E.W., House, A., Hunt, W., Iverson, A., Jamil, A., Jiang, X.S., Karelin, A., Kaufman, L.J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K.S., Larson, A., Leach, K.G., Lenardo, B.G., Leonard, D.S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., Massacret, N., McMichael, K., Mong, B., Moore, D.C., Murray, K., Nattress, J., Natzke, C.R., Ngwadla, X.E., Ni, K., Nolan, A., Nowicki, S.C., Nzobadila Ondze, J.C., Orrell, J.L., Ortega, G.S., Overman, C.T., Peltz-Smalley, H., Perna, A., Pinto Franco, T., Pocar, A., Pratte, J.-F., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rebeiro, B.M., Rescia, S., Retière, F., Richardson, G., Ringuette, J., Riot, V., Rowson, P.C., Roy, N., Rudolph, L., Saldanha, R., Sangiorgio, S., Schwartz, S., Soderstrom, J., Soma, A.K., Spadoni, F., Stekhanov, V., Sun, X.L., Teimoori Barakoohi, E., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O.A., Underwood, R., van Bruggen, E., Veeraraghavan, V., Vidal, M., Viel, S., Walent, M., Wamba, K., Wang, Q.D., Wang, W., Wang, Y.G., Watts, M., Wei, W., Wen, L.J., Wichoski, U., Wilde, S., Worcester, M., Wu, S., Wu, X.M., Yang, H., Yang, L., Yvaine, M., Zeldovich, O., Zhao, J., and Ziegler, T.

Published
2023
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27. Measurements of electron transport in liquid and gas Xenon using a laser-driven photocathode

Author

Njoya, O., Tsang, T., Tarka, M., Fairbank, W., Kumar, K. S., Rao, T., Wager, T., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hossl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krucken, R., Kuchenkov, A., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retiere, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

Measurements of electron drift properties in liquid and gaseous xenon are reported. The electrons are generated by the photoelectric effect in a semi-transparent gold photocathode driven in transmission mode with a pulsed ultraviolet laser. The charges drift and diffuse in a small chamber at various electric fields and a fixed drift distance of 2.0 cm. At an electric field of 0.5 kV/cm, the measured drift velocities and corresponding temperature coefficients respectively are $1.97 \pm 0.04$ mm/$\mu$s and $(-0.69\pm0.05)$\%/K for liquid xenon, and $1.42 \pm 0.03$ mm/$\mu$s and $(+0.11\pm0.01)$\%/K for gaseous xenon at 1.5 bar. In addition, we measure longitudinal diffusion coefficients of $25.7 \pm 4.6$ cm$^2$/s and $149 \pm 23$ cm$^2$/s, for liquid and gas, respectively. The quantum efficiency of the gold photocathode is studied at the photon energy of 4.73 eV in liquid and gaseous xenon, and vacuum. These charge transport properties and the behavior of photocathodes in a xenon environment are important in designing and calibrating future large scale noble liquid detectors.

Published
2019
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28. Reflectivity and PDE of VUV4 Hamamatsu SiPMs in Liquid Xenon

Author

Nakarmi, P., Ostrovskiy, I., Soma, A. K., Retiere, F., Kharusi, S. Al, Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Blatchford, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Mamahit, S. Byrne, Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Doria, L., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößle, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lv, P., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, l J. L., Ortega, G. S., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, St-Hilaire, G., Stekhanov, r V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Understanding reflective properties of materials and photodetection efficiency (PDE) of photodetectors is important for optimizing energy resolution and sensitivity of the next generation neutrinoless double beta decay, direct detection dark matter, and neutrino oscillation experiments that will use noble liquid gases, such as nEXO, DARWIN, DarkSide-20k, and DUNE. Little information is currently available about reflectivity and PDE in liquid noble gases, because such measurements are difficult to conduct in a cryogenic environment and at short enough wavelengths. Here we report a measurement of specular reflectivity and relative PDE of Hamamatsu VUV4 silicon photomultipliers (SiPMs) with 50 micrometer micro-cells conducted with xenon scintillation light (~175 nm) in liquid xenon. The specular reflectivity at 15 deg. incidence of three samples of VUV4 SiPMs is found to be 30.4+/-1.4%, 28.6+/-1.3%, and 28.0+/-1.3%, respectively. The PDE at normal incidence differs by +/-8% (standard deviation) among the three devices. The angular dependence of the reflectivity and PDE was also measured for one of the SiPMs. Both the reflectivity and PDE decrease as the angle of incidence increases. This is the first measurement of an angular dependence of PDE and reflectivity of a SiPM in liquid xenon., Comment: 21 pages, 15 figures, 6 tables. As accepted by JINST

Published
2019
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29. Measurement of the scintillation and ionization response of liquid xenon at MeV energies in the EXO-200 experiment

Author

Collaboration, EXO-200, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Neilson, R., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retiere, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Tosi, D., Totev, T. I., Veenstra, B., Veeraraghavan, V., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegle, T.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Liquid xenon (LXe) is employed in a number of current and future detectors for rare event searches. We use the EXO-200 experimental data to measure the absolute scintillation and ionization yields generated by $\gamma$ interactions from $^{228}$Th (2615~keV), $^{226}$Ra (1764~keV) and $^{60}$Co (1332~keV and 1173~keV) calibration sources, over a range of electric fields. The $W$-value that defines the recombination-independent energy scale is measured to be $11.5~\pm~0.5$~(syst.)~$\pm~0.1$~(stat.) eV. These data are also used to measure the recombination fluctuations in the number of electrons and photons produced by the calibration sources at the MeV-scale, which deviate from extrapolations of lower-energy data. Additionally, a semi-empirical model for the energy resolution of the detector is developed, which is used to constrain the recombination efficiency, i.e., the fraction of recombined electrons that result in the emission of a detectable photon. Detailed measurements of the absolute charge and light yields for MeV-scale electron recoils are important for predicting the performance of future neutrinoless double beta decay detectors.

Published
2019
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30. Simulation of charge readout with segmented tiles in nEXO

Author

Li, Z., Cen, W. R., Robinson, A., Moore, D. C., Wen, L. J., Odian, A., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

nEXO is a proposed experiment to search for the neutrino-less double beta decay ($0\nu\beta\beta$) of $^{136}$Xe in a tonne-scale liquid xenon time projection chamber (TPC). The nEXO TPC will be equipped with charge collection tiles to form the anode. In this work, the charge reconstruction performance of this anode design is studied with a dedicated simulation package. A multi-variate method and a deep neural network are developed to distinguish simulated $0\nu\beta\beta$ signals from backgrounds arising from trace levels of natural radioactivity in the detector materials. These simulations indicate that the nEXO TPC with charge-collection tiles shows promising capability to discriminate the $0\nu\beta\beta$ signal from backgrounds. The estimated half-life sensitivity for $0\nu\beta\beta$ decay is improved by $\sim$20$~(32)\%$ with the multi-variate~(deep neural network) methods considered here, relative to the sensitivity estimated in the nEXO pre-conceptual design report.

Published
2019
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31. Search for Neutrinoless Double-Beta Decay with the Complete EXO-200 Dataset

Author

Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Danilov, M., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A search for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{136}$Xe is performed with the full EXO-200 dataset using a deep neural network to discriminate between $0\nu\beta\beta$ and background events. Relative to previous analyses, the signal detection efficiency has been raised from 80.8% to 96.4$\pm$3.0% and the energy resolution of the detector at the Q-value of $^{136}$Xe $0\nu\beta\beta$ has been improved from $\sigma/E=1.23\%$ to $1.15\pm0.02\%$ with the upgraded detector. Accounting for the new data, the median 90% confidence level $0\nu\beta\beta$ half-life sensitivity for this analysis is $5.0 \cdot 10^{25}$ yr with a total $^{136}$Xe exposure of 234.1 kg$\cdot$yr. No statistically significant evidence for $0\nu\beta\beta$ is observed, leading to a lower limit on the $0\nu\beta\beta$ half-life of $3.5\cdot10^{25}$ yr at the 90% confidence level., Comment: v1, 7 pages, 5 figures; v2, fix references; v3, update to accepted version

Published
2019
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32. Characterization of the Hamamatsu VUV4 MPPCs for nEXO

Author

Gallina, G., Giampa, P., Retiere, F., Kroeger, J., Zhang, G., Ward, M., Margetak, P., Lic, G., Tsang, T., Doria, L., Kharusi, S. Al, Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Blatchford, J., Brodsky, J. P., Brown, E., Brunner, T., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Gautam, P., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hoßl, J., House, A., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lana, Y., Larson, A., Lenardo, B. G., Leonarda, D. S., Lik, S., Li, Z., Licciardi, C., Linw, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepkez, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rescia, S., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Vachon, F., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

In this paper we report on the characterization of the Hamamatsu VUV4 (S/N: S13370-6152) Vacuum Ultra-Violet (VUV) sensitive Silicon Photo-Multipliers (SiPMs) as part of the development of a solution for the detection of liquid xenon scintillation light for the nEXO experiment. Various SiPM features, such as: dark noise, gain, correlated avalanches, direct crosstalk and Photon Detection Efficiency (PDE) were measured in a dedicated setup at TRIUMF. SiPMs were characterized in the range $163 \text{ } \text{K} \leq \text{T}\leq 233 \text{ } \text{K}$. At an over voltage of $3.1\pm0.2$ V and at $\text{T}=163 \text{ }\text{K}$ we report a number of Correlated Avalanches (CAs) per pulse in the $1 \upmu\text{s}$ interval following the trigger pulse of $0.161\pm0.005$. At the same settings the Dark-Noise (DN) rate is $0.137\pm0.002 \text{ Hz/mm}^{2}$. Both the number of CAs and the DN rate are within nEXO specifications. The PDE of the Hamamatsu VUV4 was measured for two different devices at $\text{T}=233 \text{ }\text{K}$ for a mean wavelength of $189\pm7\text{ nm}$. At $3.6\pm0.2$ V and $3.5\pm0.2$ V of over voltage we report a PDE of $13.4\pm2.6\text{ }\%$ and $11\pm2\%$, corresponding to a saturation PDE of $14.8\pm2.8\text{ }\%$ and $12.2\pm2.3\%$, respectively. Both values are well below the $24\text{ }\%$ saturation PDE advertised by Hamamatsu. More generally, the second device tested at $3.5\pm0.2$ V of over voltage is below the nEXO PDE requirement. The first one instead yields a PDE that is marginally close to meeting the nEXO specifications. This suggests that with modest improvements the Hamamatsu VUV4 MPPCs could be considered as an alternative to the FBK-LF SiPMs for the final design of the nEXO detector.

Published
2019
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33. Efficacy of the AS04-adjuvanted HPV-16/18 vaccine: Pooled analysis of the Costa Rica Vaccine and PATRICIA randomized controlled trials

Author

Tota, Joseph E, Struyf, Frank, Sampson, Joshua N, Gonzalez, Paula, Ryser, Martin, Herrero, Rolando, Schussler, John, Karkada, Naveen, Rodriguez, Ana Cecilia, Folschweiller, Nicolas, Porras, Carolina, Schiffman, Mark, Schiller, John T, Quint, Wim, Kreimer, Aimée R, Wheeler, Cosette M, Hildesheim, Allan, Cortés, Bernal, González, Paula, Jiménez, Silvia E, Rodríguez, Ana Cecilia, Lowy, Douglas R, Wacholder, Sholom, Pinto, Ligia A, Kemp, Troy J, van Doorn, Leen-Jan, Struijk, Linda, Palefsky, Joel M, Darragh, Teresa M, Stoler, Mark H, Garland, SM, Skinner, SR, De Sutter, P, Poppe, WAJ, De Carvalho, NS, Teixeira, JC, Ferguson, L, Ferguson, M, Papp, K, Ramjattan, B, Orr, PH, Paavonen, J, Höpker, WD, Tobgui, S Jensen-El, Liverani, CA, Limson, GM, Marti, M Campins, Castro, M, Centeno, C, Chow, SN, Angsuwathana, S, Lewis, D, Ackerman, R, Caldwell, M, Chambers, C, Chatterjee, A, Harper, D, Sperling, R, Stapleton, J, Waldbaum, A, Lee, P, and Awedikian, Rafi

Subjects
Sexually Transmitted Infections, Immunization, Cancer, Biotechnology, Infectious Diseases, HPV and/or Cervical Cancer Vaccines, Vaccine Related, Clinical Research, Clinical Trials and Supportive Activities, Cervical Cancer, Prevention, HIV/AIDS, Adjuvants, Immunologic, Adolescent, Adult, Costa Rica, Female, Human papillomavirus 16, Human papillomavirus 18, Humans, Papillomavirus Infections, Papillomavirus Vaccines, Randomized Controlled Trials as Topic, Retrospective Studies, Treatment Outcome, Uterine Cervical Neoplasms, Young Adult, Uterine Cervical Dysplasia, Costa Rica Vaccine Trial and PATRICIA Study, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundThe AS04-adjuvanted HPV16/18 (AS04-HPV16/18) vaccine provides excellent protection against targeted human papillomavirus (HPV) types and a variable degree of cross-protection against others, including types 6/11/31/33/45. High efficacy against any cervical intraepithelial neoplasia grade 3 or greater (CIN3+; >90%) suggests that lower levels of protection may exist for a wide range of oncogenic HPV types, which is difficult to quantify in individual trials. Pooling individual-level data from two randomized controlled trials, we aimed to evaluate AS04-HPV16/18 vaccine efficacy against incident HPV infections and cervical abnormalities .MethodsData were available from the Costa Rica Vaccine Trial (NCT00128661) and Papilloma Trial Against Cancer in Young Adults trial (NCT00122681), two large-scale, double-blind randomized controlled trials of the AS04-HPV16/18 vaccine. Primary analyses focused on disease-free women with no detectable cervicovaginal HPV at baseline.ResultsA total of 12 550 women were included in our primary analyses (HPV arm = 6271, control arm = 6279). Incidence of 6-month persistent oncogenic and nononcogenic infections, excluding known and accepted protected types 6/11/16/18/31/33/45 (focusing on 34/35/39/40/42/43/44/51/52/53/54/56/58/59/66/68/73/70/74), was statistically significantly lower in the HPV arm than in the control arm (efficacy = 9.9%, 95% confidence interval [CI] = 1.7% to 17.4%). Statistically significant efficacy (P

Published
2020

34. Looking for Cherenkov light in liquid xenon with LoLX

Author

Galli, L., Kharusi, S. Al, Brunner, T., Chambers, C., Chana, B., de St. Croix, A., Darroch, L., Egan, E., Francesconi, M., Gallacher, D., Giampa, P., Lefebvre, J., Margetak, P., Marti, J., McElroy, T., Patel, M., Rebeiro, B., Retiere, F., Rudolf, L., Signorelli, G., Stracka, S., Tétrault, M.-A., Viel, S., and Xie, L.

Published
2023
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35. Study of Silicon Photomultiplier Performance in External Electric Fields

Author

Sun, X. L., Tolba, T., Cao, G. F., Lv, P., Wen, L. J., Odian, A., Vachon, F., Alamre, A., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Côté, M., Craycraft, A., Cree, W., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Harris, D., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Moe, M., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Sinclair, D., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Veenstra, B., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors
Abstract

We report on the performance of silicon photomultiplier (SiPM) light sensors operating in electric field strength up to 30 kV/cm and at a temperature of 149K, relative to their performance in the absence of an external electric field. The SiPM devices used in this study show stable gain, photon detection efficiency, and rates of correlated pulses, when exposed to external fields, within the estimated uncertainties. No observable physical damage to the bulk or surface of the devices was caused by the exposure., Comment: 16 pages, 12 figures, 2 tables and two conferences (INPC2016 and TIPP2017)

Published
2018
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36. Imaging individual barium atoms in solid xenon for barium tagging in nEXO

Author

Chambers, C., Walton, T., Fairbank, D., Craycraft, A., Yahne, D. R., Todd, J., Iverson, A., Fairbank, W., Alamare, A., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Cree, W., Côté, M., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., Michel, T., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Schubert, A., Sinclair, D., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Tolba, T., Tsang, T. I. Totev. R., Tsang, T., Vachon, F., Veenstra, B., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The search for neutrinoless double beta decay probes the fundamental properties of neutrinos, including whether or not the neutrino and antineutrino are distinct. Double beta detectors are large and expensive, so background reduction is essential for extracting the highest sensitivity. The identification, or 'tagging', of the $^{136}$Ba daughter atom from double beta decay of $^{136}$Xe provides a technique for eliminating backgrounds in the nEXO neutrinoless double beta decay experiment. The tagging scheme studied in this work utilizes a cryogenic probe to trap the barium atom in solid xenon, where the barium atom is tagged via fluorescence imaging in the solid xenon matrix. Here we demonstrate imaging and counting of individual atoms of barium in solid xenon by scanning a focused laser across a solid xenon matrix deposited on a sapphire window. When the laser sits on an individual atom, the fluorescence persists for $\sim$30~s before dropping abruptly to the background level, a clear confirmation of one-atom imaging. No barium fluorescence persists following evaporation of a barium deposit to a limit of $\leq$0.16\%. This is the first time that single atoms have been imaged in solid noble element. It establishes the basic principle of a barium tagging technique for nEXO.

Published
2018

37. VUV-sensitive Silicon Photomultipliers for Xenon Scintillation Light Detection in nEXO

Author

Jamil, A., Ziegler, T., Hufschmidt, P., Li, G., Lupin-Jimenez, L., Michel, T., Ostrovskiy, I., Retière, F., Schneider, J., Wagenpfeil, M., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P., Beck, D., Belov, V., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Côté, M., Dalmasson, J., Daniels, T., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Didberidze, T., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Harris, D., Hasan, M., Heffner, M., Hoppe, E. W., House, A., Hughes, M., Hößl, J., Ito, Y., Iverson, A., Jewell, M., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Mong, B., Moore, D., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Overman, C. T., Ortega, G. S., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schubert, A., Sinclair, D., Skarpaas, K., Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wang, Q., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., and Zhou, Y.

Subjects
Physics - Instrumentation and Detectors
Abstract

Future tonne-scale liquefied noble gas detectors depend on efficient light detection in the VUV range. In the past years Silicon Photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large area avalanche photodiodes. The next generation double beta decay experiment, nEXO, with a 5 tonne liquid xenon time projection chamber, will use SiPMs for detecting the $178\,\text{nm}$ xenon scintillation light, in order to achieve an energy resolution of $\sigma / Q_{\beta\beta} = 1\, \%$. This paper presents recent measurements of the VUV-HD generation SiPMs from Fondazione Bruno Kessler in two complementary setups. It includes measurements of the photon detection efficiency with gaseous xenon scintillation light in a vacuum setup and dark measurements in a dry nitrogen gas setup. We report improved photon detection efficiency at $175\,\text{nm}$ compared to previous generation devices, that would meet the criteria of nEXO. Furthermore, we present the projected nEXO detector light collection and energy resolution that could be achieved by using these SiPMs., Comment: 11 pages, 13 figures, 2 tables

Published
2018
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38. nEXO Pre-Conceptual Design Report

Author

nEXO Collaboration, Kharusi, S. Al, Alamre, A., Albert, J. B., Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Conley, R., Coon, M., Côté, M., Craycraft, A., Cree, W., Dalmasson, J., Daniels, T., Danovitch, D., Darroch, L., Daugherty, S. J., Daughhetee, J., DeVoe, R., Delaquis, S., Der Mesrobian-Kabakian, A., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fierlinger, P., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Haller, G., Hansen, E. V., Harris, D., Hasi, J., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kenney, C., Killick, R., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Lewis, C. M., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McFarlane, K., Michel, T., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Nguyen, T., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Patel, M., Peña-Perez, A., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Schubert, A., Segal, J., Skarpaas~VIII, K., Soma, A. K., Spitaels, K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veenstra, B., Veeraraghavan, V., Visser, G., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

The projected performance and detector configuration of nEXO are described in this pre-Conceptual Design Report (pCDR). nEXO is a tonne-scale neutrinoless double beta ($0\nu\beta\beta$) decay search in $^{136}$Xe, based on the ultra-low background liquid xenon technology validated by EXO-200. With $\simeq$ 5000 kg of xenon enriched to 90% in the isotope 136, nEXO has a projected half-life sensitivity of approximately $10^{28}$ years. This represents an improvement in sensitivity of about two orders of magnitude with respect to current results. Based on the experience gained from EXO-200 and the effectiveness of xenon purification techniques, we expect the background to be dominated by external sources of radiation. The sensitivity increase is, therefore, entirely derived from the increase of active mass in a monolithic and homogeneous detector, along with some technical advances perfected in the course of a dedicated R&D program. Hence the risk which is inherent to the construction of a large, ultra-low background detector is reduced, as the intrinsic radioactive contamination requirements are generally not beyond those demonstrated with the present generation $0\nu\beta\beta$ decay experiments. Indeed, most of the required materials have been already assayed or reasonable estimates of their properties are at hand. The details described herein represent the base design of the detector configuration as of early 2018. Where potential design improvements are possible, alternatives are discussed. This design for nEXO presents a compelling path towards a next generation search for $0\nu\beta\beta$, with a substantial possibility to discover physics beyond the Standard Model., Comment: 182 pages, minor revisions

Published
2018

39. Deep Neural Networks for Energy and Position Reconstruction in EXO-200

Author

Delaquis, S., Jewell, M. J., Ostrovskiy, I., Weber, M., Ziegler, T., Dalmasson, J., Kaufman, L. J., Richards, T., Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Harris, D., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Johnson, A., Karelin, A., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, G. S., Li, S., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D., Murray, K., Njoya, O., Odian, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Schmidt, S., Schubert, A., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Veeraraghavan, V., Vuilleumier, J. -L., Wagenpfeil, M., Waite, A., Watkins, J., Wen, L. J., Wichoski, U., Wrede, G., Xia, Q., Yang, L., Yen, Y. -R., and Zeldovich, O. Ya.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

We apply deep neural networks (DNN) to data from the EXO-200 experiment. In the studied cases, the DNN is able to reconstruct the relevant parameters - total energy and position - directly from raw digitized waveforms, with minimal exceptions. For the first time, the developed algorithms are evaluated on real detector calibration data. The accuracy of reconstruction either reaches or exceeds what was achieved by the conventional approaches developed by EXO-200 over the course of the experiment. Most existing DNN approaches to event reconstruction and classification in particle physics are trained on Monte Carlo simulated events. Such algorithms are inherently limited by the accuracy of the simulation. We describe a unique approach that, in an experiment such as EXO-200, allows to successfully perform certain reconstruction and analysis tasks by training the network on waveforms from experimental data, either reducing or eliminating the reliance on the Monte Carlo., Comment: Accepted version. 33 pages, 28 figures

Published
2018
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41. Nature's Combinatorial Biosynthesis Produces Vatiamides A–F

Author

Moss, Nathan A, Seiler, Grant, Leão, Tiago F, Castro‐Falcón, Gabriel, Gerwick, Lena, Hughes, Chambers C, and Gerwick, William H

Subjects
Chemical Sciences, Genetics, Amino Acid Sequence, Click Chemistry, Cyanobacteria, Lipopeptides, Multigene Family, Peptide Synthases, Sequence Alignment, biosynthesis, combinatorial biosynthesis, cyanobacteria, polyketides, non-ribosomal peptides, Organic Chemistry, Chemical sciences
Abstract

Hybrid type I PKS/NRPS biosynthetic pathways typically proceed in a collinear manner wherein one molecular building block is enzymatically incorporated in a sequence that corresponds to gene arrangement. In this work, genome mining combined with the use of a fluorogenic azide-based click probe led to the discovery and characterization of vatiamides A-F, three structurally diverse alkynylated lipopeptides, and their brominated analogues, from the cyanobacterium Moorea producens ASI16Jul14-2. These derive from a unique combinatorial non-collinear PKS/NRPS system encoded by a 90 kb gene cluster in which an upstream PKS cassette interacts with three separate cognate NRPS partners. This is facilitated by a series of promiscuous intermodule PKS-NRPS docking motifs possessing identical amino acid sequences. This interaction confers a new type of combinatorial capacity for creating molecular diversity in microbial systems.

Published
2019

42. Imaging individual barium atoms in solid xenon for barium tagging in nEXO

Author

Chambers, C, Walton, T, Fairbank, D, Craycraft, A, Yahne, DR, Todd, J, Iverson, A, Fairbank, W, Alamare, A, Albert, JB, Anton, G, Arnquist, IJ, Badhrees, I, Barbeau, PS, Beck, D, Belov, V, Bhatta, T, Bourque, F, Brodsky, JP, Brown, E, Brunner, T, Burenkov, A, Cao, GF, Cao, L, Cen, WR, Charlebois, SA, Chiu, M, Cleveland, B, Coon, M, Cree, W, Côté, M, Dalmasson, J, Daniels, T, Darroch, L, Daugherty, SJ, Daughhetee, J, Delaquis, S, Mesrobian-Kabakian, A Der, DeVoe, R, Dilling, J, Ding, YY, Dolinski, MJ, Dragone, A, Echevers, J, Fabris, L, Farine, J, Feyzbakhsh, S, Fontaine, R, Fudenberg, D, Giacomini, G, Gornea, R, Gratta, G, Hansen, EV, Heffner, M, Hoppe, EW, Hößl, J, House, A, Hufschmidt, P, Hughes, M, Ito, Y, Jamil, A, Jessiman, C, Jewell, MJ, Jiang, XS, Karelin, A, Kaufman, LJ, Kodroff, D, Koffas, T, Kravitz, S, Krücken, R, Kuchenkov, A, Kumar, KS, Lan, Y, Larson, A, Leonard, DS, Li, G, Li, S, Li, Z, Licciardi, C, Lin, YH, Lv, P, MacLellan, R, Michel, T, Mong, B, Moore, DC, Murray, K, Newby, RJ, Ning, Z, Njoya, O, Nolet, F, Nusair, O, Odgers, K, Odian, A, Oriunno, M, Orrell, JL, Ortega, GS, Ostrovskiy, I, Overman, CT, Parent, S, and Piepke, A

Subjects
physics.ins-det, nucl-ex, Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, nEXO Collaboration, General Science & Technology
Abstract

The search for neutrinoless double beta decay probes the fundamentalproperties of neutrinos, including whether or not the neutrino and antineutrinoare distinct. Double beta detectors are large and expensive, so backgroundreduction is essential for extracting the highest sensitivity. Theidentification, or 'tagging', of the $^{136}$Ba daughter atom from double betadecay of $^{136}$Xe provides a technique for eliminating backgrounds in thenEXO neutrinoless double beta decay experiment. The tagging scheme studied inthis work utilizes a cryogenic probe to trap the barium atom in solid xenon,where the barium atom is tagged via fluorescence imaging in the solid xenonmatrix. Here we demonstrate imaging and counting of individual atoms of bariumin solid xenon by scanning a focused laser across a solid xenon matrixdeposited on a sapphire window. When the laser sits on an individual atom, thefluorescence persists for $\sim$30~s before dropping abruptly to the backgroundlevel, a clear confirmation of one-atom imaging. No barium fluorescencepersists following evaporation of a barium deposit to a limit of $\leq$0.16\%.This is the first time that single atoms have been imaged in solid nobleelement. It establishes the basic principle of a barium tagging technique fornEXO.

Published
2019

43. Neolymphostin A Is a Covalent Phosphoinositide 3‑Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester

Author

Castro-Falcón, Gabriel, Seiler, Grant S, Demir, Özlem, Rathinaswamy, Manoj K, Hamelin, David, Hoffmann, Reece M, Makowski, Stefanie L, Letzel, Anne-Catrin, Field, Seth J, Burke, John E, Amaro, Rommie E, and Hughes, Chambers C

Subjects
Enzyme Inhibitors, Esters, Molecular Docking Simulation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Conformation, Quinolines, TOR Serine-Threonine Kinases, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
Abstract

Using a novel chemistry-based assay for identifying electrophilic natural products in unprocessed extracts, we identified the PI3-kinase/mTOR dual inhibitor neolymphostin A from Salinispora arenicola CNY-486. The method further showed that the vinylogous ester substituent on the neolymphostin core was the exact site for enzyme conjugation. Tandem MS/MS experiments on PI3Kα treated with the inhibitor revealed that neolymphostin covalently modified Lys802 with a shift in mass of +306 amu, corresponding to addition of the inhibitor and elimination of methanol. The binding pose of the inhibitor bound to PI3Kα was modeled, and hydrogen-deuterium exchange mass spectrometry experiments supported this model. Against a panel of kinases, neolymphostin showed good selectivity for PI3-kinase and mTOR. In addition, the natural product blocked AKT phosphorylation in live cells with an IC50 of ∼3 nM. Taken together, neolymphostin is the first reported example of a covalent kinase inhibitor from the bacterial domain of life.

Published
2018

44. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Author

Kearney, Sara E, Zahoránszky-Kőhalmi, Gergely, Brimacombe, Kyle R, Henderson, Mark J, Lynch, Caitlin, Zhao, Tongan, Wan, Kanny K, Itkin, Zina, Dillon, Christopher, Shen, Min, Cheff, Dorian M, Lee, Tobie D, Bougie, Danielle, Cheng, Ken, Coussens, Nathan P, Dorjsuren, Dorjbal, Eastman, Richard T, Huang, Ruili, Iannotti, Michael J, Karavadhi, Surendra, Klumpp-Thomas, Carleen, Roth, Jacob S, Sakamuru, Srilatha, Sun, Wei, Titus, Steven A, Yasgar, Adam, Zhang, Ya-Qin, Zhao, Jinghua, Andrade, Rodrigo B, Brown, M Kevin, Burns, Noah Z, Cha, Jin K, Mevers, Emily E, Clardy, Jon, Clement, Jason A, Crooks, Peter A, Cuny, Gregory D, Ganor, Jake, Moreno, Jesus, Morrill, Lucas A, Picazo, Elias, Susick, Robert B, Garg, Neil K, Goess, Brian C, Grossman, Robert B, Hughes, Chambers C, Johnston, Jeffrey N, Joullie, Madeleine M, Kinghorn, A Douglas, Kingston, David GI, Krische, Michael J, Kwon, Ohyun, Maimone, Thomas J, Majumdar, Susruta, Maloney, Katherine N, Mohamed, Enas, Murphy, Brian T, Nagorny, Pavel, Olson, David E, Overman, Larry E, Brown, Lauren E, Snyder, John K, Porco, John A, Rivas, Fatima, Ross, Samir A, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T, Xu, Zhengren, Shen, Ben, Shi, Wei, Stephenson, Corey RJ, Verano, Alyssa L, Tan, Derek S, Tang, Yi, Taylor, Richard E, Thomson, Regan J, Vosburg, David A, Wu, Jimmy, Wuest, William M, Zakarian, Armen, Zhang, Yufeng, Ren, Tianjing, Zuo, Zhong, Inglese, James, Michael, Sam, Simeonov, Anton, Zheng, Wei, Shinn, Paul, Jadhav, Ajit, Boxer, Matthew B, Hall, Matthew D, Xia, Menghang, Guha, Rajarshi, and Rohde, Jason M

Subjects
Chemical Sciences
Abstract

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were analyzed using a variety of quality control metrics, and the resultant assay profiles were explored using statistical methods, such as clustering and compound promiscuity analyses. Individual compounds were then sorted by structural class and activity profiles. Differential behavior based on these classifications, as well as noteworthy activities, are outlined herein. One such highlight is the activity of (-)-2(S)-cathafoline, which was found to stabilize calcium levels in the endoplasmic reticulum. The workflow described here illustrates a pilot effort to broadly survey the biological potential of natural products by utilizing the power of automation and high-throughput screening.

Published
2018

45. Search for nucleon decays with EXO-200

Author

Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Didberidze, T., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gornea, R., Graham, K., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Homiller, S., Hufschmidt, P., Hughes, M., Jamil, A., Jewell, M. J., Johnson, A., Johnston, S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, G. S., Li, S., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D., Murray, K., Nelson, R., Njoya, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Schmidt, S., Schubert, A., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Tolba, T., Tsang, R., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Waite, A., Walton, T., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., Zettlemoyer, J., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

A search for instability of nucleons bound in $^{136}$Xe nuclei is reported with 223 kg$\cdot$yr exposure of $^{136}$Xe in the EXO-200 experiment. Lifetime limits of 3.3$\times 10^{23}$ and 1.9$\times 10^{23}$ yrs are established for nucleon decay to $^{133}$Sb and $^{133}$Te, respectively. These are the most stringent to date, exceeding the prior decay limits by a factor of 9 and 7, respectively.

Published
2017
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46. Sensitivity and discovery potential of the proposed nEXO experiment to neutrinoless double beta decay

Author

nEXO Collaboration, Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Côté, M., Craycraft, A., Cree, W., Dalmasson, J., Daniels, T., Daugherty, S. J., Daughhetee, J., DeVoe, R., Delaquis, S., Der Mesrobian-Kabakian, A., Didberidze, T., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Fabris, L., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Giacomini, G., Gornea, R., Graham, K., Gratta, G., Hansen, E. V., Harris, D., Hasan, M., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Johnson, T. N., Johnston, S., Karelin, A., Kaufman, L. J., Killick, R., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Schubert, A., Sinclair, D., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Visser, G., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Yang, L., Yen, Y. -R., Zeldovich, O., Zettlemoyer, J., Zhang, X., Zhao, J., Zhou, Y., and Ziegler, T.

Subjects
Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract

The next-generation Enriched Xenon Observatory (nEXO) is a proposed experiment to search for neutrinoless double beta ($0\nu\beta\beta$) decay in $^{136}$Xe with a target half-life sensitivity of approximately $10^{28}$ years using $5\times10^3$ kg of isotopically enriched liquid-xenon in a time projection chamber. This improvement of two orders of magnitude in sensitivity over current limits is obtained by a significant increase of the $^{136}$Xe mass, the monolithic and homogeneous configuration of the active medium, and the multi-parameter measurements of the interactions enabled by the time projection chamber. The detector concept and anticipated performance are presented based upon demonstrated realizable background rates., Comment: v2 as published

Published
2017
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47. Characterization of an Ionization Readout Tile for nEXO

Author

nEXO Collaboration, Jewell, M., Schubert, A., Cen, W. R., Dalmasson, J., DeVoe, R., Fabris, L., Gratta, G., Jamil, A., Li, G., Odian, A., Patel, M., Pocar, A., Qiu, D., Wang, Q., Wen, L. J., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P., Beck, D., Belov, V., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Côté, M., Daniels, T., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., Didberidze, T., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Giacomini, G., Gornea, R., Hansen, E. V., Harris, D., Hasan, M., Heffner, M., Hoppe, E. W., House, A., Hufschmidt, P., Hughes, M., Hößl, J., Ito, Y., Iverson, A., Jiang, X. S., Johnston, S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Odgers, K., Oriunno, M., Orrell, J. L., Ostrovskiy, I., Overman, C. T., Ortega, G. S., Parent, S., Piepke, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retiere, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Sinclair, D., Skarpaas, K., Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Weber, M., Wei, W., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xuan, Z., Yang, L., Yayun, D., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., Zhe, N., Zhou, Y., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors
Abstract

A new design for the anode of a time projection chamber, consisting of a charge-detecting "tile", is investigated for use in large scale liquid xenon detectors. The tile is produced by depositing 60 orthogonal metal charge-collecting strips, 3~mm wide, on a 10~\si{\cm} $\times$ 10~\si{\cm} fused-silica wafer. These charge tiles may be employed by large detectors, such as the proposed tonne-scale nEXO experiment to search for neutrinoless double-beta decay. Modular by design, an array of tiles can cover a sizable area. The width of each strip is small compared to the size of the tile, so a Frisch grid is not required. A grid-less, tiled anode design is beneficial for an experiment such as nEXO, where a wire tensioning support structure and Frisch grid might contribute radioactive backgrounds and would have to be designed to accommodate cycling to cryogenic temperatures. The segmented anode also reduces some degeneracies in signal reconstruction that arise in large-area crossed-wire time projection chambers. A prototype tile was tested in a cell containing liquid xenon. Very good agreement is achieved between the measured ionization spectrum of a $^{207}$Bi source and simulations that include the microphysics of recombination in xenon and a detailed modeling of the electrostatic field of the detector. An energy resolution $\sigma/E$=5.5\% is observed at 570~\si{keV}, comparable to the best intrinsic ionization-only resolution reported in literature for liquid xenon at 936~V/\si{cm}., Comment: 18 pages, 13 figures, as published

Published
2017
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48. Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector

Author

Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Didberidze, T., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gornea, R., Graham, K., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Jamil, A., Jewell, M. J., Johnson, A., Johnston, S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, G. S., Li, S., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D., Murray, K., Nelson, R., Njoya, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Rowson, P. C., Russell, J. J., Schmidt, S., Schubert, A., Sinclair, D., Stekhanov, V., Tarka, M., Tolba, T., Tsang, R., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Waite, A., Walton, T., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., Zettlemoyer, J., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Results from a search for neutrinoless double-beta decay $0\nu\beta\beta$ of $^{136}$Xe are presented using the first year of data taken with the upgraded EXO-200 detector. Relative to previous searches by EXO-200, the energy resolution of the detector has been improved to $\sigma/E$=1.23%, the electric field in the drift region has been raised by 50%, and a system to suppress radon in the volume between the cryostat and lead shielding has been implemented. In addition, analysis techniques that improve topological discrimination between $0\nu\beta\beta$ and background events have been developed. Incorporating these hardware and analysis improvements, the median 90% confidence level $0\nu\beta\beta$ half-life sensitivity after combining with the full data set acquired before the upgrade has increased 2-fold to $3.7 \times 10^{25}$ yr. No statistically significant evidence for $0\nu\beta\beta$ is observed, leading to a lower limit on the $0\nu\beta\beta$ half-life of $1.8\times10^{25}$ yr at the 90% confidence level., Comment: 6 pages, 4 figures, final version submitted to PRL

Published
2017
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49. Searches for Double Beta Decay of $^{134}$Xe with EXO-200

Author

Collaboration, EXO-200, Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Didberidze, T., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gornea, R., Graham, K., Gratta, G., Hall, C., Hoessl, J., Hufschmidt, P., Hughes, M., Jamil, A., Jewell, M. J., Johnson, A., Johnston, S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, S., Licciardi, C., Lin, Y. H., MacLellan, R., Marino, M. G., Michel, T., Mong, B., Moore, D., Murray, K., Nelson, R., Njoya, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Rowson, P. C., Russell, J. J., Schubert, A., Sinclair, D., Smith, E., Stekhanov, V., Tarka, M., Tolba, T., Tsang, R., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Waite, A., Walton, J., Walton, T., Weber, M., Wen, L. J., Wichoski, U., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., Zettlemoyer, J., and Ziegler, T.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Searches for double beta decay of $^{134}$Xe were performed with EXO-200, a single-phase liquid xenon detector designed to search for neutrinoless double beta decay of $^{136}$Xe. Using an exposure of $29.6\text{ kg}\!\cdot\!\text{yr}$, the lower limits of $\text{T}_{1/2}^{2\nu\beta\!\beta}>8.7\cdot10^{20}\text{ yr}$ and $\text{T}_{1/2}^{0\nu\beta\!\beta}>1.1\cdot10^{23}\text{ yr}$ at 90% confidence level were derived, with corresponding half-life sensitivities of $1.2\cdot10^{21}\text{ yr}$ and $1.9\cdot10^{23}\text{ yr}$. These limits exceed those in the literature for $^{134}$Xe, improving by factors of nearly $10^{5}$ and 2 for the two antineutrino and neutrinoless modes, respectively., Comment: 8 pages, 4 figures

Published
2017
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50. Trace radioactive impurities in final construction materials for EXO-200

Author

Leonard, D. S., Auty, D., Didberidze, T., Gornea, R., Grinberg, P., MacLellan, R., Methven, B., Piepke, A., Vuilleumier, J. -L., Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Graham, K., Gratta, G., Hall, C., Herrin, S., Hoessl, J., Hufschmidt, P., Hughes, M., Jamil, A., Jewell, M. J., Johnson, A., Johntson, S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., LePort, F., Li, S., Licciardi, C., Lin, Y. H., Mackay, D., Marino, M. G., Michel, T., Mong, B., Moore, D., Murray, K., Neilson, R., Nelson, R., Njoya, O., Odian, A., Ostrovskiy, I., Pocar, A., Pushkin, K., Retière, F., Rowson, P. C., Russell, J. J., Schubert, A., Sinclair, D., Smith, E., Stekhanov, V., Tarka, M., Tolba, T., Tsang, R., Wagenpfeil, M., Waite, A., Walton, J., Walton, T., Wamba, K., Weber, M., Wen, L. J., Wichoski, U., Wodin, J., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., Zettlemoyer, J., and Ziegler, T.

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

We report results from a systematic measurement campaign conducted to identify low radioactivity materials for the construction of the EXO-200 double beta decay experiment. Partial results from this campaign have already been reported in a 2008 paper by the EXO collaboration. Here we release the remaining data, collected since 2007, to the public. The data reported were obtained using a variety of analytic techniques. The measurement sensitivities are among the best in the field. Construction of the EXO-200 detector has been concluded, and Phase-I data was taken from 2011 to 2014. The detector's extremely low background implicitly verifies the measurements and the analysis assumptions made during construction and reported in this paper., Comment: 28 pages, 5 figures

Published
2017
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