307 results on '"Cetinkaya, Merih"'
Search Results
2. Epidemiology and Outcomes of Neonatal Meningitis: Results of the Turkish Neo-Meningitis Nationwide Study
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Oncel, Mehmet Yekta, Cizmeci, Mehmet N., Karadag-Oncel, Eda, Elvan-Tuz, Aysegul, Canpolat, Fuat Emre, Akin, Mustafa Ali, Uslu, Sinan, Cetinkaya, Merih, Erdeve, Omer, Koc, Esin, Kadioglu-Simsek, Gulsum, Buyuktiryaki, Mehmet, Karal, Ferhan Iren, Kiray-Bas, Evrim, Dincer, Emre, Ustun, Huseyin, Varal, Ipek Guney, Dogan, Pelin, Celik, Mahmut, Erol, Elif, Demirel, Nihal, Tokgoz-Cuni, Betul, Okulu, Emel, Lacinbala, Turan, Hirfanoglu, Ibrahim Murat, Tas, Melda, Takci, Sahin, Kocatepe, Gaye, Zenciroglu, Aysegul, Bidev, Duygu, Ozdemir, Ramazan, Gokce, Ismail Kursad, Okur, Nilufer, Yurttutan, Sadik, Konak, Murat, Aykanat, Alper, Arslanoglu, Sertac, Deliloglu, Burak, Yazici, Aybuke, Kulali, Ferit, Gunes, Damla, Yangin-Ergon, Ezgi, Akcan, Baris, Arayici, Sema, Dilek, Mustafa, Sahin, Suzan, Engur, Defne, Yilmaz, Nisel, Yilmaz, Dilek, and Elmali, Ferhan
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- 2024
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3. Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury
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Koc, Cansu, Cakir, Aysen, Salman, Berna, Ocalan, Busra, Alkan, Tulin, Kafa, Ilker Mustafa, Cetinkaya, Merih, and Cansev, Mehmet
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Lung diseases -- Causes of -- Prevention ,Infants (Newborn) -- Diseases ,Choline -- Physiological aspects ,Pyrophosphates -- Physiological aspects ,Biological sciences - Abstract
Antenatal steroid administration to pregnant women at risk of prematurity provides pulmonarymaturation in infants, while it has limited effects on incidence of bronchopulmonary dysplasia (BPD), the clinical expression of hyperoxia-induced lung injury (HILI). Cytidine-5'-diphosphate choline (CDP-choline) was shown to alleviate HILI when administered to newborn rats. Therefore, we investigated effects of maternal administration of CDP-choline, alone or in combination with betamethasone, on lung maturation in neonatal rats subjected to HILI immediately after birth. Pregnant rats were randomly assigned to one of the four treatments: saline (1mL/kg), CDP-choline (300 mg/kg), betamethasone (0.4mg/kg), or CDP-choline plus betamethasone (combination therapy). From postnatal day 1 to 11, pups born to mothers in the same treatment group were pooled and randomly assigned to either normoxia or hyperoxia group. Biochemical an d histopathological effects of CDP-choline on neonatal lung tissue were evaluated. Antenatal CDP-choline treatment increased levels of phosphatidylcholine and total lung phospholipids, decreased apoptosis, and improved alveolarization. The outcomes were further improved with combination therapy compared to the administration of CDP-choline or betamethasone alone. These results demonstrate that antenatal CDP-choline treatment provides benefit in experimental HILI either alone or more intensively when administered along with a steroid, suggesting a possible utility for CDP-choline against BPD. Key words: betamethasone, bronchopulmonary dysplasia, citicoline, newborn rat, 1. Introduction Bronchopulmonary dysplasia (BPD) is the most common long-term respiratory complication of premature birth. Despite improvements such as antenatal corticosteroid therapy, non-invasive ventilation practices, surfactant replacement therapy, and advanced [...]
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- 2023
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4. Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms
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Akat, Ayberk, Yilmaz Semerci, Seda, Ugurel, Osman Mutluhan, Erdemir, Aysegul, Danhaive, Olivier, Cetinkaya, Merih, and Turgut-Balik, Dilek
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- 2022
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5. Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study
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De Luca, Daniele, Perkins, Elizabeth, Tingay, David G., Buonsenso, Danilo, Centorrino, Roberta, Vivanti, Alexandre, Rooze, Shancy, Pilar-Orive, Francisco J, Gonçalves-Ferri, Walusa Assad, Amigoni, Angela, de Carvalho, Werther Brunow, Jornada Krebs, Vera Lucia, AL-Naqeeb, Niran, Danhaive, Olivier, Cetinkaya, Merih, Stein, Howard, Shoemaker, Jessica, Danhaive, Olivier, Torpiano, Paul, Vetter-Laracy, Susanne, Rogdo, Bjarte, Elsayed, Yasser, Chidini, Giovanna, Kneyber, Martin, Medina Villanueva, Alberto, Polito, Angelo, Brouwer, Carole NM, and Rimensberger, Peter
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- 2023
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6. Effect of Left and Right Semi-Elevated Side-Lying Positions on Feeding Performance of Preterm Infants
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Aktaş, Eda, Aykanat Girgin, Burcu, Gözen, Duygu, Ergün, Kübra, Pekyiğit, Aylin, and Çetınkaya, Merih
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- 2022
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7. Alternative consent methods used in the multinational, pragmatic, randomised clinical trial SafeBoosC-III
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Vestager, Maria Linander; https://orcid.org/0000-0002-3273-0791, Hansen, Mathias Lühr; https://orcid.org/0000-0003-1957-7005, Greisen, Gorm, Pellicer, Adelina, Chathasaigh, Caitriona Ni, Lecart, Chantal, Knoepfli, Claudia, Hagmann, Cornelia; https://orcid.org/0000-0003-2647-9809, Gallo, Dario, Ergenekon, Ebru, Hatzidaki, Eleftheria, Dempsey, Eugene, Papathoma, Evangelina, Dimitrou, Gabriel, Pichler, Gerhard; https://orcid.org/0000-0003-2405-7143, Hahn, Gitte Holst, Naulaers, Gunnar, Fuchs, Hans; https://orcid.org/0000-0003-1303-3699, Ozkan, Hilal, de las Cuevas, Isabel, Serrano-Viñuales, Itziar, Sirc, Jan, de Buyst, Julie, Sarafidis, Kosmos, Arrusa, Luis, Baserga, Mariana, Stocker, Martin; https://orcid.org/0000-0002-1461-333X, Cetinkaya, Merih, Alsina-Casanova, Miguel; https://orcid.org/0000-0002-0139-7279, Fumagalli, Monica, et al, Vestager, Maria Linander; https://orcid.org/0000-0002-3273-0791, Hansen, Mathias Lühr; https://orcid.org/0000-0003-1957-7005, Greisen, Gorm, Pellicer, Adelina, Chathasaigh, Caitriona Ni, Lecart, Chantal, Knoepfli, Claudia, Hagmann, Cornelia; https://orcid.org/0000-0003-2647-9809, Gallo, Dario, Ergenekon, Ebru, Hatzidaki, Eleftheria, Dempsey, Eugene, Papathoma, Evangelina, Dimitrou, Gabriel, Pichler, Gerhard; https://orcid.org/0000-0003-2405-7143, Hahn, Gitte Holst, Naulaers, Gunnar, Fuchs, Hans; https://orcid.org/0000-0003-1303-3699, Ozkan, Hilal, de las Cuevas, Isabel, Serrano-Viñuales, Itziar, Sirc, Jan, de Buyst, Julie, Sarafidis, Kosmos, Arrusa, Luis, Baserga, Mariana, Stocker, Martin; https://orcid.org/0000-0002-1461-333X, Cetinkaya, Merih, Alsina-Casanova, Miguel; https://orcid.org/0000-0002-0139-7279, Fumagalli, Monica, and et al
- Abstract
Background The process of obtaining prior informed consent for experimental treatment does not fit well into the clinical reality of acute and intensive care. The therapeutic window of interventions is often short, which may reduce the validity of the consent and the rate of enrolled participants, to delay trial completion and reduce the external validity of the results. Deferred consent and ‘opt-out’ are alternative consent methods. The SafeBoosC-III trial was a randomised clinical trial investigating the benefits and harms of cerebral oximetry monitoring in extremely preterm infants during the first 3 days after birth, starting within the first 6 h after birth. Prior, deferred and opt-out consent were all allowed by protocol. This study aimed to evaluate the use of different consent methods in the SafeBoosC-III trial, Furthermore, we aimed to describe and analyse concerns or complaints that arose during the first 6 months of trial conduct. Methods All 70 principal investigators were invited to join this descriptive ancillary study. Each principal investigator received a questionnaire on the use of consent methods in their centre during the SafeBoosC-III trial, including the possibility to describe any concerns related to the consent methods used during the first 6 months of the trial, as raised by the parents or the clinical staff. Results Data from 61 centres were available. In 43 centres, only prior informed consent was used: in seven, only deferred consent. No centres used the opt-out method only, but five centres used prior and deferred, five used prior, deferred and opt-out (all possibilities) and one used both deferred and opt-out. Six centres applied to use the opt-out method by their local research ethics committee but were denied using it. One centre applied to use deferred consent but was denied. There were only 23 registered concerns during the execution of the trial. Conclusions Consent by opt-out was allowed by the protocol in this multinational trial
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- 2024
8. Early Hemodynamic Effects of Mydriatic Eye Drops in Preterm Infants.
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Dincer, Emre, Gonen, Ilker, Bornaun, Helen A., Yasa, Beril, Babayigit, Aslan, Kurum, Ozge, Bayramoğlu, Sadık E., and Cetinkaya, Merih
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VITAL signs ,OXYGEN saturation ,OPHTHALMIC drugs ,MYDRIATICS ,HEMODYNAMICS ,TREATMENT effectiveness ,DESCRIPTIVE statistics ,NEAR infrared spectroscopy ,LONGITUDINAL method ,GESTATIONAL age ,EYE examination ,PYRIDINE ,COMPARATIVE studies ,RETROLENTAL fibroplasia ,PHENYLEPHRINE ,EVALUATION - Abstract
Objective Mydriatic eye drops used for retinopathy of prematurity (ROP) examination can cause systemic effects, and there are case reports of serious adverse effects in the literature. In this prospective study, we aimed to evaluate the early hemodynamic effects of mydriatic eye drops to understand the possible mechanisms of adverse effects. Study Design Between December 2018 and March 2019, preterm babies less than 32 gestational weeks and who underwent ophthalmologic examination in our unit were included. The vital signs (heart rate, respiratory rate, oxygen saturation [SpO
2 ], and blood pressure values), cerebral and mesenteric tissue saturation by near-infrared spectroscopy (NIRS), and left ventricular functions of infants were recorded before and after applying mydriatic eye drops (2.5% phenylephrine and 0.5% tropicamide). The data were compared statistically. Strict adherence to prevent systemic absorption of the eye drops was applied. Results Thirty-two mydriasis procedures were evaluated in 26 patients. The mean gestational age was 28.5 ± 1.7 weeks, and the mean birth weight was 943 ± 233 g. There were no significant differences in terms of vital signs of infants including heart rate, blood pressure, and oxygen saturation [SpO2 ] levels before and after eye-drop application. In addition, NIRS values showed no significant differences between before and after measurements. No significant differences were detected at echocardiographic evaluation performed before and after mydriatic administration. No adverse reaction was observed in the study population during the study. Conclusion This is the first study that evaluated the early hemodynamic effects of mydriatic eye drops used for ROP screening by vital signs, NIRS, and echocardiographic evaluation. Mydriatic eye drops have no significant effect on early hemodynamic parameters including vital signs, NIRS, and echocardiographic findings in preterm infants. We suggest that a cautious approach for avoiding the systemic absorption of these agents may prevent the possible early systemic effects in this high-risk population. Key Points Mydriatic eye drops are commonly used for pupil dilatation before retinopathy of prematurity examination, and there are reports of serious adverse events caused by these drops. Due to the adverse events of eye drops, hemodynamic effects of these agents were investigated by clinical findings, near-infrared spectroscopy, and echocardiography. No significant early hemodynamic effect was observed so avoiding systemic effects may be prevented with precautions. [ABSTRACT FROM AUTHOR]- Published
- 2024
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9. Regional pulmonary oxygen saturations in late preterm and term infants with respiratory distress at birth
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Yasa, Beril, primary, Kersin, Sinem Gülcan, additional, Cetinkaya, Merih, additional, Ozek, Eren, additional, and Bilgen, Hulya, additional
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- 2024
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10. Prioritising respiratory syncytial virus prevention in low-income and middle-income countries
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Carbonell-Estrany, Xavier, primary, Simões, Eric AF, additional, Bont, Louis J, additional, Paes, Bosco A, additional, Carbonell-Estrany, Xavier, additional, Ayuk, Adaeze, additional, Gentile, Angela, additional, Greenough, Anne, additional, Moreno, Antonio, additional, Sharma, Arun, additional, Mejias, Asuncion, additional, Rodgers-Gray, Barry, additional, Resch, Bernhard, additional, Fauroux, Brigette, additional, Rodriguez-Martinez, Carlos E, additional, El Saleeby, Chadi, additional, Huskins, W Charles, additional, Cohen, Cheryl, additional, Greenberg, David, additional, Baraldi, Eugenio, additional, Anderson, Evan, additional, Martinon Torres, Federico, additional, Polack, Fernando F, additional, Piedimonte, Giovanni, additional, Nair, Harish, additional, Gans, Hayley, additional, Zar, Heather J, additional, Moriuchi, Hiroyuki, additional, Oshitani, Hitoshi, additional, Mitchell, Ian, additional, Nokes, D James, additional, Sheikh, Jarju, additional, Pernica, Jeffrey, additional, Papenburg, Jesse, additional, Robinson, Joan, additional, De Jesus-Cornejo, Joanne, additional, Langley, Joanne, additional, Liese, Johannes, additional, Figueras Aloy, Jose, additional, Torres Torretti, Juan Pablo, additional, Edwards, Kathryn, additional, Krilov, Leonard, additional, Divaratne, Maduja, additional, Sanchez Luna, Manuel, additional, Lanari, Marcello, additional, Scotta, Marcelo, additional, Garba, Maria, additional, Mori, Masaaki, additional, Cetinkaya, Merih, additional, Goldstein, Mitchell, additional, Khuri-Bulos, Najwa, additional, Vain, Nestor E, additional, Papadopoulus, Nikolaos, additional, Homaira, Nusrat, additional, Ramilo, Octavio, additional, Manzoni, Paolo, additional, Munywoki, Patrick, additional, Piedra, Pedro A, additional, Moschovis, Peter, additional, Openshaw, Peter, additional, Bassat, Quique, additional, Stein, Renato, additional, Thwaites, Richard, additional, Muthugala, Rohitha, additional, Ulloa-Gutierrez, Rolando, additional, Dagan, Ron, additional, Rodriguez Fernandez, Rosa, additional, Kusuda, Satoshi, additional, Madhi, Shabir, additional, Broor, Shobha, additional, Drysdale, Simon B, additional, Basnet, Sudha, additional, Heikkinen, Terho, additional, Avadhanula, Vasanthi, additional, Saez-Llorens, Xavier, additional, Wang, Xin, additional, Li, You, additional, and Mathew, Joseph L, additional
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- 2023
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11. Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study.
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Yasa, Beril, Memur, Seyma, Ozturk, Dilek Y., Bagci, Onur, Uslu, Sait I., and Cetinkaya, Merih
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NASOPHARYNX microbiology ,LENGTH of stay in hospitals ,REVERSE transcriptase polymerase chain reaction ,NEONATAL necrotizing enterocolitis ,COVID-19 ,COMMUNICABLE diseases ,PREMATURE infants ,INTRATRACHEAL drug administration ,PULMONARY surfactant ,PATENT ductus arteriosus ,CASE-control method ,RETROSPECTIVE studies ,GESTATIONAL age ,PREGNANCY outcomes ,ARTIFICIAL respiration ,PREGNANCY complications ,SYMPTOMS ,DESCRIPTIVE statistics ,BIRTH weight ,RESPIRATORY distress syndrome ,BRONCHOPULMONARY dysplasia ,CHILDREN ,PREGNANCY - Abstract
Objective Novel coronavirus disease 2019 (COVID-19) is a disease associated with atypical pneumonia caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The first cases of COVID-19 were reported in Wuhan at the end of 2019. Transmission usually occurs via infected droplets and close personal contact; the possibility of vertical transmission is still under debate. This retrospective study aimed to analyze clinical characteristics of premature infants born to mothers with symptomatic COVID-19 disease. Study Design This case control study compared the clinical and laboratory data of 20 premature infants born to mothers infected with SARS-CoV-2 with sex and gestational age–matched historical controls. Results The median gestational age and birth weight in both groups were similar. Respiratory distress developed in 11 (55.5%) infants in study group and 19 (47.5%) infants in control group. Mechanical ventilation and endotracheal surfactant administration rates were similar. Median duration of hospitalization was 8.5 (2–76) days in study group and 12 days in historical controls. Real-time reverse-transcription polymerase chain reaction tests (RT-PCR) of nasopharyngeal swab samples for SARS-CoV-2 were found to be negative twice, in the first 24 hours and later at 24 to 48 hours of life. No neutropenia or thrombocytopenia was detected in the study group. Patent ductus arteriosus, bronchopulmonary dysplasia, and necrotizing enterocolitis rates were similar between groups. No mortality was observed in both groups. Conclusion To the best of our knowledge, this is one of the few studies evaluating the clinical outcomes of premature infants born to SARS-CoV-2 infected mothers. There was no evidence of vertical transmission of SARS-CoV-2 from symptomatic SARS-CoV-2-infected women to the neonate in our cohort. The neonatal outcomes also seem to be favorable with no mortality in preterm infants. Key Points SARS-CoV-2 pandemic is a challenge for pregnant women. Neonatal outcomes of premature infants born to mothers infected with SARS-CoV-2 not well defined. SARS-CoV-2 infection seems to have no adverse effect on mortality and morbidity in premature infants. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Evaluation of perfusion index and left ventricular output changes in low cardiac output syndrome after arterial switch operation.
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Öztürk, Dilek Yavuzcan, Öztürk, Erkut, Dıkmen, Rahime Tuten, Ozcanoglu, Hatice Dilek, Toprak, Hamza Halil, Tuzun, Behzat, Tanıdır, İbrahim Cansaran, Hatemi, Ali Can, and Cetinkaya, Merih
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- 2023
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13. Editorial: Case reports in neonatology 2022
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Meyer, Sascha, primary, Wagner, Michael, additional, and Cetinkaya, Merih, additional
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- 2023
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14. Cerebral Oximetry Monitoring in Extremely Preterm Infants
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Hansen, Mathias L., primary, Pellicer, Adelina, additional, Hyttel-Sørensen, Simon, additional, Ergenekon, Ebru, additional, Szczapa, Tomasz, additional, Hagmann, Cornelia, additional, Naulaers, Gunnar, additional, Mintzer, Jonathan, additional, Fumagalli, Monica, additional, Dimitriou, Gabriel, additional, Dempsey, Eugene, additional, Tkaczyk, Jakub, additional, Cheng, Guoqiang, additional, Fredly, Siv, additional, Heuchan, Anne M., additional, Pichler, Gerhard, additional, Fuchs, Hans, additional, Nesargi, Saudamini, additional, Hahn, Gitte H., additional, Piris-Borregas, Salvador, additional, Širc, Jan, additional, Alsina-Casanova, Miguel, additional, Stocker, Martin, additional, Ozkan, Hilal, additional, Sarafidis, Kosmas, additional, Hopper, Andrew O., additional, Karen, Tanja, additional, Rzepecka-Weglarz, Beata, additional, Oguz, Serife S., additional, Arruza, Luis, additional, Memisoglu, Asli C., additional, del Rio Florentino, Ruth, additional, Baserga, Mariana, additional, Maton, Pierre, additional, Truttmann, Anita C., additional, de las Cuevas, Isabel, additional, Agergaard, Peter, additional, Zafra, Pamela, additional, Bender, Lars, additional, Lauterbach, Ryszard, additional, Lecart, Chantal, additional, de Buyst, Julie, additional, El-Khuffash, Afif, additional, Curley, Anna, additional, Vaccarello, Olalla O., additional, Miletin, Jan, additional, Papathoma, Evangelia, additional, Vesoulis, Zachary, additional, Vento, Giovanni, additional, Cornette, Luc, additional, Lopez, Laura S., additional, Yasa, Beril, additional, Klamer, Anja, additional, Agosti, Massimo, additional, Baud, Olivier, additional, Mastretta, Emmanuele, additional, Cetinkaya, Merih, additional, McCall, Karen, additional, Zeng, Shujuan, additional, Hatzidaki, Eleftheria, additional, Bargiel, Agata, additional, Marciniak, Sylwia, additional, Gao, Xiaoyan, additional, Huijia, Lin, additional, Chalak, Lina, additional, Yang, Ling, additional, Rao, Shashidhar A., additional, Xu, Xin, additional, Gonzalez, Begoña L., additional, Wilinska, Maria, additional, Yin, Zhaoqing, additional, Sadowska-Krawczenko, Iwona, additional, Serrano-Viñuales, Itziar, additional, Krolak-Olejnik, Barbara, additional, Ybarra, Marta M., additional, Morales-Betancourt, Catalina, additional, Korček, Peter, additional, Teresa-Palacio, Marta, additional, Mosca, Fabio, additional, Hergenhan, Anja, additional, Koksal, Nilgun, additional, Tsoni, Konstantia, additional, Kadri, Munaf M., additional, Knöpfli, Claudia, additional, Rafinska-Wazny, Elzbieta, additional, Akin, Mustafa S., additional, Nordvik, Tone, additional, Peng, Zhang, additional, Kersin, Sinem G., additional, Thewissen, Liesbeth, additional, Alarcon, Ana, additional, Healy, David, additional, Urlesberger, Berndt, additional, Baş, Münevver, additional, Baumgartner, Jana, additional, Skylogianni, Eleni, additional, Karadyova, Veronika, additional, Valverde, Eva, additional, Bergon-Sendin, Elena, additional, Kucera, Jachym, additional, Pisoni, Silvia, additional, Wang, Le, additional, Smits, Anne, additional, Sanchez-Salmador, Rebeca, additional, Rasmussen, Marie I., additional, Olsen, Markus H., additional, Jensen, Aksel K., additional, Gluud, Christian, additional, Jakobsen, Janus C., additional, and Greisen, Gorm, additional
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- 2023
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15. Different Placental Transfusion Strategies and Their Effects on Short - Term Hematological Parameters in Term Infants
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Yasa, Beril, primary, Gonen, Ilker, additional, Dincer, Emre, additional, Babayigit, Aslan, additional, Saglam, Ozge, additional, and Cetinkaya, Merih, additional
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- 2023
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16. SARS-CoV-2 Viral Load in Pregnant Women and Association with Maternal Disease Severity and Neonatal Outcomes
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Yasa, Beril, primary, Karabulut, Nuran, additional, Uslu, Sait Ilker, additional, Memur, Seyma, additional, Yavuzcan Ozturk, Dilek, additional, Bagci, Onur, additional, Can Buker, Halime Sema, additional, Polat, Ibrahim, additional, and Cetinkaya, Merih, additional
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- 2023
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17. Cerebral Oximetry Monitoring in Extremely Preterm Infants
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Hansen, Mathias L., Pellicer, Adelina, Hyttel-Sørensen, Simon, Ergenekon, Ebru, Szczapa, Tomasz, Hagmann, Cornelia, Naulaers, Gunnar, Mintzer, Jonathan, Fumagalli, Monica, Dimitriou, Gabriel, Dempsey, Eugene, Tkaczyk, Jakub, Cheng, Guoqiang, Fredly, Siv, Heuchan, Anne M., Pichler, Gerhard, Fuchs, Hans, Nesargi, Saudamini, Hahn, Gitte H., Piris-Borregas, Salvador, Širc, Jan, Alsina-Casanova, Miguel, Stocker, Martin, Ozkan, Hilal, Sarafidis, Kosmas, Hopper, Andrew O., Karen, Tanja, Rzepecka-Weglarz, Beata, Oguz, Serife S., Arruza, Luis, Memisoglu, Asli C., Del Rio Florentino, Ruth, Baserga, Mariana, Maton, Pierre, Truttmann, Anita C., De Las Cuevas, Isabel, Agergaard, Peter, Zafra, Pamela, Bender, Lars, Lauterbach, Ryszard, Lecart, Chantal, De Buyst, Julie, El-Khuffash, Afif, Curley, Anna, Vaccarello, Olalla O., Miletin, Jan, Papathoma, Evangelia, Vesoulis, Zachary, Vento, Giovanni, Cornette, Luc, Lopez, Laura S., Yasa, Beril, Klamer, Anja, Agosti, Massimo, Baud, Olivier, Mastretta, Emmanuele, Cetinkaya, Merih, McCall, Karen, Zeng, Shujuan, Hatzidaki, Eleftheria, Bargiel, Agata, Marciniak, Sylwia, Gao, Xiaoyan, Huijia, Lin, Chalak, Lina, Yang, Ling, Rao, Shashidhar A., Xu, Xin, Gonzalez, Begoña L., Wilinska, Maria, Yin, Zhaoqing, Sadowska-Krawczenko, Iwona, Serrano-Viñuales, Itziar, Krolak-Olejnik, Barbara, Ybarra, Marta M., Morales-Betancourt, Catalina, Korček, Peter, Teresa-Palacio, Marta, Mosca, Fabio, Hergenhan, Anja, Koksal, Nilgun, Tsoni, Konstantia, Kadri, Munaf M., Knöpfli, Claudia, Rafinska-Wazny, Elzbieta, Akin, Mustafa S., Nordvik, Tone, Peng, Zhang, Kersin, Sinem G., Thewissen, Liesbeth, Alarcon, Ana, Healy, David, Urlesberger, Berndt, Baş, Münevver, Baumgartner, Jana, Skylogianni, Eleni, Karadyova, Veronika, Valverde, Eva, Bergon-Sendin, Elena, Kucera, Jachym, Pisoni, Silvia, Wang, Le, Smits, Anne, Sanchez-Salmador, Rebeca, Rasmussen, Marie I., Olsen, Markus H., Jensen, Aksel K., Gluud, Christian, Jakobsen, Janus C., Greisen, Gorm, Hansen, Mathias L., Pellicer, Adelina, Hyttel-Sørensen, Simon, Ergenekon, Ebru, Szczapa, Tomasz, Hagmann, Cornelia, Naulaers, Gunnar, Mintzer, Jonathan, Fumagalli, Monica, Dimitriou, Gabriel, Dempsey, Eugene, Tkaczyk, Jakub, Cheng, Guoqiang, Fredly, Siv, Heuchan, Anne M., Pichler, Gerhard, Fuchs, Hans, Nesargi, Saudamini, Hahn, Gitte H., Piris-Borregas, Salvador, Širc, Jan, Alsina-Casanova, Miguel, Stocker, Martin, Ozkan, Hilal, Sarafidis, Kosmas, Hopper, Andrew O., Karen, Tanja, Rzepecka-Weglarz, Beata, Oguz, Serife S., Arruza, Luis, Memisoglu, Asli C., Del Rio Florentino, Ruth, Baserga, Mariana, Maton, Pierre, Truttmann, Anita C., De Las Cuevas, Isabel, Agergaard, Peter, Zafra, Pamela, Bender, Lars, Lauterbach, Ryszard, Lecart, Chantal, De Buyst, Julie, El-Khuffash, Afif, Curley, Anna, Vaccarello, Olalla O., Miletin, Jan, Papathoma, Evangelia, Vesoulis, Zachary, Vento, Giovanni, Cornette, Luc, Lopez, Laura S., Yasa, Beril, Klamer, Anja, Agosti, Massimo, Baud, Olivier, Mastretta, Emmanuele, Cetinkaya, Merih, McCall, Karen, Zeng, Shujuan, Hatzidaki, Eleftheria, Bargiel, Agata, Marciniak, Sylwia, Gao, Xiaoyan, Huijia, Lin, Chalak, Lina, Yang, Ling, Rao, Shashidhar A., Xu, Xin, Gonzalez, Begoña L., Wilinska, Maria, Yin, Zhaoqing, Sadowska-Krawczenko, Iwona, Serrano-Viñuales, Itziar, Krolak-Olejnik, Barbara, Ybarra, Marta M., Morales-Betancourt, Catalina, Korček, Peter, Teresa-Palacio, Marta, Mosca, Fabio, Hergenhan, Anja, Koksal, Nilgun, Tsoni, Konstantia, Kadri, Munaf M., Knöpfli, Claudia, Rafinska-Wazny, Elzbieta, Akin, Mustafa S., Nordvik, Tone, Peng, Zhang, Kersin, Sinem G., Thewissen, Liesbeth, Alarcon, Ana, Healy, David, Urlesberger, Berndt, Baş, Münevver, Baumgartner, Jana, Skylogianni, Eleni, Karadyova, Veronika, Valverde, Eva, Bergon-Sendin, Elena, Kucera, Jachym, Pisoni, Silvia, Wang, Le, Smits, Anne, Sanchez-Salmador, Rebeca, Rasmussen, Marie I., Olsen, Markus H., Jensen, Aksel K., Gluud, Christian, Jakobsen, Janus C., and Greisen, Gorm
- Abstract
BACKGROUND The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. METHODS In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks’ postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis. RESULTS A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks’ postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative risk with cerebral oximetry, 1.03; 95% confidence interval, 0.90 to 1.18; P=0.64). The incidence of serious adverse events did not differ between the two groups. CONCLUSIONS In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks’ postmenstrual age than usual care. (Funded by the Elsass Foundation and others; SafeBoosC-III ClinicalTrials.gov number, NCT03770741. opens in new tab.), Background The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking. Methods In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks' postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis. Results A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks' postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative risk with cerebral oximetry, 1.03; 95% confidence interval, 0.90 to 1.18; P=0.64). The incidence of serious adverse events did not differ between the two groups. Conclusions In extremely preterm infants, treatment guided by cerebral oximetry monitoring for the first 72 hours after birth was not associated with a lower incidence of death or severe brain injury at 36 weeks' postmenstrual age than usual care. (Funded by the Elsass Foundation and others; SafeBoosC-III ClinicalTrials.gov number, NCT03770741.).
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- 2023
18. Endocan and Soluble Triggering Receptor Expressed on Myeloid Cells-1 as Novel Markers for Neonatal Sepsis
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Saldir, Mehmet, Tunc, Turan, Cekmez, Ferhat, Cetinkaya, Merih, Kalayci, Tugce, Fidanci, Kursat, Babacan, Oguzhan, Erdem, Galip, Kocak, Necmettin, Sari, Erkan, Akgul, Emin Ozgur, and Kul, Mustafa
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- 2015
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19. Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants: Follow-Up of the OPTIMIST-A Randomized Clinical Trial.
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Dargaville, Peter A., Kamlin, C. Omar F., Orsini, Francesca, Wang, Xiaofang, De Paoli, Antonio G., Kanmaz Kutman, H. Gozde, Cetinkaya, Merih, Kornhauser-Cerar, Lilijana, Derrick, Matthew, Özkan, Hilal, Hulzebos, Christian V., Schmölzer, Georg M., Aiyappan, Ajit, Lemyre, Brigitte, Kuo, Sheree, Rajadurai, Victor S., O'Shea, Joyce, Biniwale, Manoj, Ramanathan, Rangasamy, and Kushnir, Alla
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NEURODEVELOPMENTAL treatment for infants ,MECONIUM aspiration syndrome ,PREMATURE infants ,CONTINUOUS positive airway pressure ,NEONATAL intensive care units ,SURFACE active agents ,RESPIRATORY distress syndrome - Abstract
Key Points: Question: For preterm infants with respiratory distress syndrome supported with continuous positive airway pressure (CPAP), does administration of surfactant via a thin catheter improve survival without moderate to severe neurodevelopmental disability (NDD) at 2 years of age compared with sham treatment? Findings: In this follow-up of a randomized clinical trial of 486 infants at 25 to 28 weeks' gestation, the composite outcome of death or NDD at 2 years of age occurred in 36.3% receiving minimally invasive surfactant therapy compared with 36.1% receiving sham treatment. Meaning: In preterm infants supported with CPAP, minimally invasive surfactant therapy did not lead to a reduction in the composite outcome of death or neurodevelopmental disability at 2 years of age. Importance: The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified. Objective: To examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years' corrected age. Design, Setting, and Participants: Follow-up study of a randomized clinical trial with blinding of clinicians and outcome assessors conducted in 33 tertiary-level neonatal intensive care units in 11 countries. The trial included 486 infants with a gestational age of 25 to 28 weeks supported with continuous positive airway pressure (CPAP). Collection of follow-up data at 2 years' corrected age was completed on December 9, 2022. Interventions: Infants assigned to MIST (n = 242) received exogenous surfactant (200 mg/kg poractant alfa) via a thin catheter; those assigned to the control group (n = 244) received sham treatment. Main Outcomes and Measures: The key secondary outcome of death or moderate to severe NDD was assessed at 2 years' corrected age. Other secondary outcomes included components of this composite outcome, as well as hospitalizations for respiratory illness and parent-reported wheezing or breathing difficulty in the first 2 years. Results: Among the 486 infants randomized, 453 had follow-up data available (median gestation, 27.3 weeks; 228 females [50.3%]); data on the key secondary outcome were available in 434 infants. Death or NDD occurred in 78 infants (36.3%) in the MIST group and 79 (36.1%) in the control group (risk difference, 0% [95% CI, −7.6% to 7.7%]; relative risk [RR], 1.0 [95% CI, 0.81-1.24]); components of this outcome did not differ significantly between groups. Secondary respiratory outcomes favored the MIST group. Hospitalization with respiratory illness occurred in 49 infants (25.1%) in the MIST group vs 78 (38.2%) in the control group (RR, 0.66 [95% CI, 0.54-0.81]) and parent-reported wheezing or breathing difficulty in 73 (40.6%) vs 104 (53.6%), respectively (RR, 0.76 [95% CI, 0.63-0.90]). Conclusions and Relevance: In this follow-up study of a randomized clinical trial of preterm infants with respiratory distress syndrome supported with CPAP, MIST compared with sham treatment did not reduce the incidence of death or NDD by 2 years of age. However, infants who received MIST had lower rates of adverse respiratory outcomes during their first 2 years of life. Trial Registration: anzctr.org.au Identifier: ACTRN12611000916943 This follow-up study of a randomized clinical trial examines the effect of minimally invasive surfactant therapy, surfactant administration via a thin catheter, on death or neurodevelopmental disability at 2 years' corrected age. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Early-Life Gut Health Indicators and Reported Prevalence of Infant Functional Constipation by Healthcare Professionals
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Muhardi, Leilani, primary, Delsing, Dianne J. M., additional, Zakharova, Irina, additional, Huysentruyt, Koen, additional, Chong, Sze-Yee, additional, Ng, Ruey Terng, additional, Darma, Andy, additional, Hegar, Badriul, additional, Hasosah, Mohammed, additional, Toro-Monjaraz, Erick, additional, Cetinkaya, Merih, additional, Chow, Chung-Mo, additional, Aw, Marion M., additional, Kudla, Urszula, additional, West, Louise Naz, additional, and Vandenplas, Yvan, additional
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- 2023
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21. Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature
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Babayigit, Aslan, Ozaydın, Seyithan, Cetinkaya, Merih, and Sander, Serdar
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- 2017
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22. Reported Prevalence and Nutritional Management of Functional Constipation among Young Children from Healthcare Professionals in Eight Countries across Asia, Europe and Latin America
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West, Louise Naz, primary, Zakharova, Irina, additional, Huysentruyt, Koen, additional, Chong, Sze-Yee, additional, Aw, Marion M., additional, Darma, Andy, additional, Hegar, Badriul, additional, Ng, Ruey Terng, additional, Hasosah, Mohammed, additional, Toro-Monjaraz, Erick, additional, Cetinkaya, Merih, additional, Chow, Chung-Mo, additional, Muhardi, Leilani, additional, Kudla, Urszula, additional, Delsing, Dianne J. M., additional, and Vandenplas, Yvan, additional
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- 2022
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23. Editorial: Transfusions in the neonatal period
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Cetinkaya, Merih, primary and Atasay, Begum, additional
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- 2022
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24. Early Hemodynamic Effects of Mydriatic Eye Drops in Preterm Infants
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Dincer, Emre, additional, Gonen, Ilker, additional, Bornaun, Helen A., additional, Yasa, Beril, additional, Babayigit, Aslan, additional, Kurum, Ozge, additional, Bayramoğlu, Sadık E., additional, and Cetinkaya, Merih, additional
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- 2022
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25. Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury
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Tayman, Cuneyt, Cekmez, Ferhat, Kafa, Ilker Mustafa, Canpolat, Fuat Emre, Cetinkaya, Merih, Tonbul, Alparslan, Uysal, Sema, Tunc, Turan, and Sarici, S. Umit
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- 2013
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26. Efectos protectores del aceite de Nigella sativa en la lesión pulmonar inducida por hiperoxia
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Tayman, Cuneyt, Cekmez, Ferhat, Kafa, Ilker Mustafa, Canpolat, Fuat Emre, Cetinkaya, Merih, Tonbul, Alparslan, Uysal, Sema, Tunc, Turan, and Sarici, S. Umit
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- 2013
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27. Severity of Maternal SARS-CoV-2 Infection in Pregnancy Predicts Neonatal Outcomes.
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Yasa, Beril, Memur, Seyma, Ozturk, Dilek Yavuzcan, Bagci, Onur, Uslu, Sait Ilker, Polat, Ibrahim, and Cetinkaya, Merih
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LENGTH of stay in hospitals ,COVID-19 ,RETROSPECTIVE studies ,SEVERITY of illness index ,PREGNANCY outcomes ,ARTIFICIAL respiration ,PREGNANCY complications ,DESCRIPTIVE statistics ,RESUSCITATION - Abstract
Objective The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak had an enormous global impact. Pregnant women with SARS-CoV-2 appear to have higher morbidity and mortality. This study aimed to evaluate the effect of the severity of maternal SARS-CoV-2 infection on neonatal outcomes. Study Design The clinical and laboratory data of 40 women and neonates evaluated retrospectively. Results This retrospective study showed that SARS-CoV-2 infection had an adverse impact on neonatal outcomes proportionally with the maternal disease severity including increased prematurity rates, postnatal resuscitation need, prolonged hospital stay and longer ventilatory support requirement in infants born to mothers with moderate or severe disease. Conclusion Maternal disease severity had adverse effects on neonatal outcomes. The severity of maternal disease was found to be associated with increased rates of prematurity, requirement of postnatal resuscitation, prolonged hospital stay, and longer ventilatory support. Key Points SARS-CoV-2 pandemic is a problem for pregnant women. Vertical transmission has been shown in limited studies. Maternal disease severity may have impact on neonatal outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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28. Risk Factors for Respiratory Syncytial Virus Infections in Moderate/Late Premature Infants in Turkey: A Prospective Multicenter Epidemiological Study
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ÖZDEMİR, HALİL, ERDEVE, ÖMER, Cebeci, Burcu, Cetinkaya, Merih, Hacimustafaoglu, Mustafa, Koksal, Nilgun, ÇELEBİ, SOLMAZ, ÖZKAN, HİLAL, TEZER, HASAN, and KOÇ, ESİN
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Male ,Turkey ,viruses ,Gestational Age ,Infant, Premature, Diseases ,Respiratory Syncytial Virus Infections ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Intensive Care Units, Neonatal ,030225 pediatrics ,Humans ,Prospective Studies ,030212 general & internal medicine ,Age Factors ,Infant, Newborn ,Infant ,virus diseases ,Obstetrics and Gynecology ,respiratory system ,Hospitalization ,Respiratory Syncytial Virus, Human ,Pediatrics, Perinatology and Child Health ,Female ,Seasons ,Infant, Premature - Abstract
Objective Respiratory syncytial virus (RSV) is one of the most prevalent causes of lower respiratory tract infection (LRTI). The primary objective of this study is to provide the risk modelling of confirmed RSV infection in children who were born preterm at 29 to 35 weeks of gestational age and presented with LRTI. Study Design This prospective, multicenter study was performed between October 2015 and March 2017. Premature infants born with gestational age between 29 and 35 weeks that were ≤2 years of age at the beginning of the RSV season and admitted to the hospital with clinical findings of LRTI during the season were included. RSV-positive and -negative infants were compared in terms of demographic features, risk factors, and requirement of hospitalization. Results RSV positive group was lower than RSV negative group and ratio of ≤3 months age at admission was significant higher in RSV (+) group. RSV-positive infants were found to be significantly born during or 3 months prior to RSV season. The rate and duration of hospitalization and need for mechanical ventilation were significantly higher in RSV positive infants. The rate and duration of hospitalization in RSV positive patients was related to the chronological age. Conclusion This study showed that preterm infants with RSV-associated LRTI significantly needed more hospitalization, intensive care admission, and mechanical ventilation. In addition need of hospitalization and duration of hospitalization were significant higher in ≤3 months of age. Therefore, we suggest the importance of palivizumab prophylaxis in infants ≤ 3 months chronological age, especially during the RSV season.
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- 2020
29. Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance
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Cekmez, Ferhat, Canpolat, Fuat Emre, Pirgon, Ozgur, Çetinkaya, Merih, Aydinoz, Secil, Suleymanoglu, Selami, Ipcioglu, Osman Metin, and Sarici, Serdar Umit
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- 2011
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30. Can we predict risk for cardiac involvement in paediatric inflammatory multi-system syndrome?
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Yakut, Nurhayat, primary, Tanidir, Ibrahim Cansaran, additional, Yakut, Kahraman, additional, Sahin, Sezgin, additional, Kilinc, Arda, additional, Kabasakal, Irem, additional, Cetinkaya, Merih, additional, Onal, Hasan, additional, and Ozturk, Erkut, additional
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- 2022
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31. A Narrative Review on the Update in the Prevalence of Infantile Colic, Regurgitation, and Constipation in Young Children: Implications of the ROME IV Criteria
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Muhardi, Leilani, primary, Aw, Marion M., additional, Hasosah, Mohammed, additional, Ng, Ruey Terng, additional, Chong, Sze Yee, additional, Hegar, Badriul, additional, Toro-Monjaraz, Erick, additional, Darma, Andy, additional, Cetinkaya, Merih, additional, Chow, Chung Mo, additional, Kudla, Urszula, additional, and Vandenplas, Yvan, additional
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- 2022
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32. Born into an Isolating World: Family-Centred Care for Babies Born to Mothers with COVID-19 the Epicentre Multinational Cohort Study
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Dowse, Georgie, primary, Perkins, Elizabeth, additional, Stein, Howard, additional, Chidini, Giovanna, additional, Danhaive, Olivier, additional, Elsayed, Yasser N., additional, de Carvalho, Werther Brunow, additional, Al-Naqeeb, Niran, additional, Rooze, Shancy, additional, Cetinkaya, Merih, additional, Vetter-Laracy, Susanne, additional, Pilar-Orive, Francisco Javier, additional, Torpiano, Paul, additional, Gonçalves-Ferri, Walusa Assad, additional, Buonsenso, Danilo, additional, Rogdo, Bjarte, additional, Medina, Alberto, additional, Polito, Angelo, additional, Brouwer, Carole, additional, Kneyber, Martin, additional, De Luca, Daniele, additional, and Tingay, David, additional
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- 2022
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33. Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms
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Akat, Ayberk, primary, Yilmaz Semerci, Seda, additional, Ugurel, Osman Mutluhan, additional, Erdemir, Aysegul, additional, Danhaive, Olivier, additional, Cetinkaya, Merih, additional, and Turgut-Balik, Dilek, additional
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- 2021
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34. Neonatal Outcomes of Premature Infants Born to Women with the Novel Coronavirus (SARS-CoV-2) Infection: A Case Control Study
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Yasa, Beril, additional, Memur, Seyma, additional, Ozturk, Dilek Y., additional, Bagci, Onur, additional, Uslu, Sait I., additional, and Cetinkaya, Merih, additional
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- 2021
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35. Hepatic Abscesses in Preterm Infants: Report of Three Cases and Review of the Literature
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Semerci, Seda Yilmaz, Babayigit, Aslan, Cebeci, Burcu, Buyukkale, Gokhan, and Cetinkaya, Merih
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- 2016
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36. Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study.
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Ozkan, Hilal, Cetinkaya, Merih, Cakir, Salih C., Saglam, Ozge, and Koksal, Nilgun
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BRONCHOPULMONARY dysplasia prevention , *NEONATAL necrotizing enterocolitis , *NEAR infrared spectroscopy , *CONFIDENCE intervals , *CEREBRAL circulation , *APNEA , *RANDOMIZED controlled trials , *T-test (Statistics) , *EARLY intervention (Education) , *CAFFEINE , *AGE factors in disease , *DESCRIPTIVE statistics , *CHI-squared test , *DATA analysis software , *LOGISTIC regression analysis , *ODDS ratio , *LONGITUDINAL method , *DISEASE risk factors , *CHILDREN - Abstract
Objective Caffeine treatment is routinely used in premature infants to prevent development of apnea and bronchopulmonary dysplasia. Although a limited number of studies have reported that early caffeine treatment may cause development of necrotizing enterocolitis (NEC) by reducing mesenteric blood flow, this issue is still under discussion. The aim of this study is to investigate the possible effect of different onset times of early caffeine treatment on mesenteric tissue oxygen saturation and NEC development in premature infants. Study Design A total of 87 preterm infants with ≤1,250-g birth weight (BW) was included in this prospective study. The cases were randomized as group 1 (first 24 hours) and group 2 (72nd hour) caffeine treatment groups and monitored by near-infrared spectroscopy (NIRS) for 72 hours from the time of admission until cerebral, renal, and mesenteric tissue oxygen saturations (rSO 2) were recorded. The cases were followed-up to the 40th week in terms of NEC and other neonatal morbidities. Results A total of 87 infants were included in the study, including 45 in group 1 and 42 in group 2. The groups were similar in terms of demographic characteristics. The incidence of NEC in group 1 (20%) was higher in comparison to group 2 (9%). The mesenteric rSO 2 values in the first 72 hours of group 1 were lower than those of group 2. Low gestational week, BW, and late onset of enteral feeding were found to be other significant risk factors for NEC. Conclusion In this study, mesenteric tissue oxygenation was lower, and NEC was higher in group 1. Mesenteric rSO 2 measurements may be useful in predicting the development of NEC in patients receiving early caffeine therapy. Key Points Onset time of early caffeine treatment may effect on mesenteric tissue oxygen saturation. Caffeine treatment that onset in the first 24 hours may be associated with NEC development. Mesenteric rSO 2 measurements may be useful in patients receiving early caffeine therapy. [ABSTRACT FROM AUTHOR]
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- 2023
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37. Translational approach for new therapeutic targets to prevent severe neonatal morbidities: from bench to bedside
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Cetinkaya, Merih, Cetinkaya, Merih, Cetinkaya, Merih, and Cetinkaya, Merih
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- 2019
38. A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society
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Oncel, Mehmet Yekta, Akın, Ilke Mungan, Kanburoglu, Mehmet Kenan, Tayman, Cuneyt, Coskun, Senay, Narter, Fatma, Er, Ilkay, Oncan, Tinatin Gelenava, Memisoglu, Asli, Cetinkaya, Merih, Oguz, Demet, Erdeve, Omer, Koc, Esin, Derme, Turan, Şahin, Dilek, Güzel, Bülent, Tekin, Arzu Bilge, Akın, Yasemin, Kale, Ahmet, Aktürk, Hüseyin, Özsürmeli, Mehmet, Gök, Nazife Reyyan, Palalıoğlu, Rabia Merve, İnan, Abdurrahman Hamdi, Özdemir, Hülya, Büyükbayrak, Esra Esim, Polat, İbrahim, Dikdere, Gülser Bingöl, Bilgin, Leyla, Sivrikoz, Tuğba Saraç, Caner, İbrahim, Yuvacı, Hilal Uslu, Kara, Nursu, Zebitay, Ali Galip, Okulu, Emel, Kalafat, Erkan, Uras, Nurdan, Tekin, Bülent, Çiftdemir, Nükhet Aladağ, Bulut, Muhammet, Bülbül, Ali, Okur, Nilüfer, Özlü, Ferda, Tekgündüz, Kadir Şerafettin, Zübarioğlu, Adil Umut, Altunhan, Hüseyin, Arcagök, Baran Cengiz, Aygün, Canan, Demir, Nihat, Gökçe, İsmail Kürşat, Gültekin, Nazlı Dilay, Toptan, Handan Hakyemez, Kulalı, Ferit, Tüfekçi, Sinan, Tüzün, Funda, Yaman, Akan, Üstün, Hüseyin, Oncel, Mehmet Yekta, Akin, Ilke Mungan, Kanburoglu, Mehmet Kenan, Tayman, Cuneyt, Coskun, Senay, Narter, Fatma, Er, Ilkay, Oncan, Tinatin Gelenava, Memisoglu, Asli, Cetinkaya, Merih, Oguz, Demet, Erdeve, Omer, and Koc, Esin
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Adult ,Male ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Turkey ,Turkish ,MEDLINE ,CHILDREN ,DIAGNOSIS ,Pregnancy ,Epidemiology ,medicine ,MANAGEMENT ,Humans ,Prospective Studies ,Pediatrics, Perinatology, and Child Health ,Pregnancy Complications, Infectious ,Prospective cohort study ,business.industry ,Cesarean Section ,SARS-CoV-2 ,Infant, Newborn ,Pregnancy Outcome ,Correction ,COVID-19 ,Infant, Low Birth Weight ,medicine.disease ,Prognosis ,Newborn ,language.human_language ,Infectious Disease Transmission, Vertical ,Multicenter study ,Premature birth ,Family medicine ,COVID-19 Nucleic Acid Testing ,Pediatrics, Perinatology and Child Health ,language ,Intensive Care, Neonatal ,Premature Birth ,Female ,Original Article ,business ,Infant, Premature - Abstract
Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Pregnant women (n = 125) who had a positive RT-PCR test and their newborns were enrolled. Cesarean section, prematurity, and low-birthweight infant rates were 71.2%, 26.4%, and 12.8%, respectively. Eight of 125 mothers (6.4%) were admitted to an intensive care unit for mechanical ventilation, among whom six died (4.8%). Majority of the newborns (86.4%) were followed in isolation rooms in the NICU. Four of 120 newborns (3.3%) had a positive RT-PCR test result. Although samples taken on the first day were negative, one neonate became positive on the second day and the other two on the fifth day. Sample from deep tracheal aspirate was positive on the first day in an intubated case. Conclusion: COVID-19 in pregnant women has important impacts on perinatal and neonatal outcomes. Maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission, and low rate of breastfeeding show that family support should be a part of the care in the NICU. Trial registration:identifier: NCT04401540 What is Known: center dot The common property of previous reports was the conclusions on maternal outcomes, rather than neonatal outcomes. center dot Published data showed similar outcomes between COVID-19 pregnant women and others. What is New: center dot Higher maternal mortality, higher rates of preterm birth and cesarean section, suspected risk of vertical transmission especially in a case with deep tracheal aspiration during the intubation, and the possible role of maternal disease severity on the outcomes are remarkable findings of this study. center dot In contrast to recommendation for breastfeeding, parents' preference to formula and expressed breast milk due to anxiety and lack of information shows that family support should be a part of the care in the NICU. Trial registration: ClinicalTrials.gov identifier: NCT04401540
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- 2020
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39. Incidence and severity of retinopathy of prematurity in Turkey
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Bas, Ahmet Yagmur, Koc, Esin, Dilmen, Ugur, Oguz, Serife Suna, Oval, Fahri, Demirel, Nihal, Zenciroglu, Aysegul, Tekin, Neslihan, Caner, Ibrahim, Arslanoglu, Sertac, Celik, Yalcn, Öztürk, Adnan, Cömert, Serdar, Bulbul, Ali, Kultursay, Nilgun, Koklu, Esad, Duman, Nuray, Koksal, Nilgun, Salihoglu, Ozgul, Coban, Asuman, Demirel, Gamze, Bolat, Fatih, Gökalp, Ayse, Satar, Mehmet, Ipek, Mehmet Sah, Bas, Evrim Kiray, Narli, Nejat, Mutlu, Mehmet, Cetinkaya, Merih, Akman, Ipek, Yigit, Sule, Narter, Fatma, Sivasli, Ercan, Ahrabi, Ali Faraghi, Atalay, Yildiz, Tanyeri, Bilge, Arsan, Saadet, Perk, Yldz, Ors, Rahmi, Tuncer, Oguz, Ecevit, Ayse, Oygur, Nihal, Ozdemir, Ozmert M, Hakan, Nilay, Aliefendioglu, Didem, Acunas, Betul, Cetin, Hasan, Ozek, Eren, Tunc, Turan, Turkmen, Munevver, Aydemir, Cumhur, and Takci, Sahin
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- 2015
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40. Treatment of neonatal fungal infective endocarditis with recombinant tissue plasminogen: activator in a low birth weight infant case report and review of the literature
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Babayigit, Aslan, Cebeci, Burcu, Buyukkale, Gokhan, Ylmaz Semerci, Seda, Bornaun, Helen, Oztarhan, Kazim, Gokce, Muge, and Cetinkaya, Merih
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- 2015
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41. FEATURES OF THE CLINICAL COURSE OF CORONAVIRUS INFECTION IN NEWBORN CHILDREN.
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Urstemova, Kamshat K., Bozhbanbayeva, Nishangul S., Cetinkaya, Merih, Manzhuova, Lyazat N., Yeraliyeva, Lyazzat T., and Issayeva, Assiya M.
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- 2022
42. Efficacy of Prophylactic Fluconazole Therapy in Decreasing the Incidence of Candida Infections in Extremely Low Birth Weight Preterm Infants
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Cetinkaya, Merih, Ercan, Tugba Erener, Saglam, Ozge Kurum, Buyukkale, Gokhan, Kavuncuoglu, Sultan, and Mete, Fatih
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- 2014
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43. Community VersusVertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study
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De Luca, Daniele, Perkins, Elizabeth, Tingay, David G., Buonsenso, Danilo, Centorrino, Roberta, Vivanti, Alexandre, Rooze, Shancy, Pilar-Orive, Francisco J, Gonçalves-Ferri, Walusa Assad, Amigoni, Angela, de Carvalho, Werther Brunow, Jornada Krebs, Vera Lucia, AL-Naqeeb, Niran, Danhaive, Olivier, Cetinkaya, Merih, Stein, Howard, Shoemaker, Jessica, Danhaive, Olivier, Torpiano, Paul, Vetter-Laracy, Susanne, Rogdo, Bjarte, Elsayed, Yasser, Chidini, Giovanna, Kneyber, Martin, Medina Villanueva, Alberto, Polito, Angelo, Brouwer, Carole NM, and Rimensberger, Peter
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Neonatal Severe Acute Respiratory Syndrome-CoronaVirus-2 infections can be community-acquired or vertically-acquired. The analysis of neonatal patients requiring hospitalization reported in the EPICENTRE worldwide registry shows that community-acquired cases have clinical features (fever, respiratory signs, feeding difficulties, P< 0.0001) and received antibiotics (P= 0.014) more frequently than vertically-acquired patients. Severe Acute Respiratory Syndrome-CoronaVirus-2 infections should be considered in the clinical workout of neonatal infections.
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- 2023
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44. Severity of Maternal SARS-CoV-2 Infection in Pregnancy Predicts Neonatal Outcomes
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Yasa, Beril, additional, Memur, Seyma, additional, Ozturk, Dilek Yavuzcan, additional, Bagci, Onur, additional, Uslu, Sait Ilker, additional, Polat, Ibrahim, additional, and Cetinkaya, Merih, additional
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- 2021
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45. Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown
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Rasmussen, Marie Isabel, primary, Hansen, Mathias Lühr, additional, Pichler, Gerhard, additional, Dempsey, Eugene, additional, Pellicer, Adelina, additional, EL-Khuffash, Afif, additional, A, Shashidhar, additional, Piris-Borregas, Salvador, additional, Alsina, Miguel, additional, Cetinkaya, Merih, additional, Chalak, Lina, additional, Özkan, Hilal, additional, Baserga, Mariana, additional, Sirc, Jan, additional, Fuchs, Hans, additional, Ergenekon, Ebru, additional, Arruza, Luis, additional, Mathur, Amit, additional, Stocker, Martin, additional, Otero Vaccarello, Olalla, additional, Szczapa, Tomasz, additional, Sarafidis, Kosmas, additional, Królak-Olejnik, Barbara, additional, Memisoglu, Asli, additional, Reigstad, Hallvard, additional, Rafińska-Ważny, Elżbieta, additional, Hatzidaki, Eleftheria, additional, Peng, Zhang, additional, Gkentzi, Despoina, additional, Viellevoye, Renaud, additional, De Buyst, Julie, additional, Mastretta, Emmanuele, additional, Wang, Ping, additional, Hahn, Gitte Holst, additional, Bender, Lars, additional, Cornette, Luc, additional, Tkaczyk, Jakub, additional, del Rio, Ruth, additional, Fumagalli, Monica, additional, Papathoma, Evangelia, additional, Wilinska, Maria, additional, Naulaers, Gunnar, additional, Sadowska-Krawczenko, Iwona, additional, Lecart, Chantal, additional, Couce, María Luz, additional, Fredly, Siv, additional, Heuchan, Anne Marie, additional, Karen, Tanja, additional, and Greisen, Gorm, additional
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- 2021
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46. Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms.
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UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de néonatologie, Akat, Ayberk, Yilmaz Semerci, Seda, Ugurel, Osman Mutluhan, Erdemir, Aysegul, Danhaive, Olivier, Cetinkaya, Merih, Turgut-Balik, Dilek, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de néonatologie, Akat, Ayberk, Yilmaz Semerci, Seda, Ugurel, Osman Mutluhan, Erdemir, Aysegul, Danhaive, Olivier, Cetinkaya, Merih, and Turgut-Balik, Dilek
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AIM: Genetic variants contribute to the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of this study is to evaluate the association of 45 SNPs with BPD susceptibility in a Turkish premature infant cohort. METHODS: Infants with gestational age <32 weeks were included. Patients were divided into BPD or no-BPD groups according to oxygen need at 28 days of life, and stratified according to the severity of BPD. We genotyped 45 SNPs, previously identified as BPD risk factors, in 192 infants. RESULTS: A total of eight SNPs were associated with BPD risk at allele level, two of which (rs4883955 on KLF12 and rs9953270 on CHST9) were also associated at the genotype level. Functional relationship maps suggested an interaction between five of these genes, converging on WNT5A, a member of the WNT pathway known to be implicated in BPD pathogenesis. Dysfunctional CHST9 and KLF12 variants may contribute to BPD pathogenesis through an interaction with WNT5A. CONCLUSIONS: We suggest investigating the role of SNPs on different genes which are in relation with the Wnt pathway in BPD pathogenesis. We identified eight SNPs as risk factors for BPD in this study. In-silico functional maps show an interaction of the genes harboring these SNPs with the WNT pathway, supporting its role in BPD pathogenesis. TRIAL REGISTRATION: NCT03467828. IMPACT: It is known that genetic factors may contribute to the development of BPD in preterm infants. Further studies are required to identify specific genes that play a role in the BPD pathway to evaluate them as a target for therapeutic interventions. Our study shows an association of BPD predisposition with certain polymorphisms on MBL2, NFKBIA, CEP170, MAGI2, and VEGFA genes at allele level and polymorphisms on CHST9 and KLF12 genes at both allele and genotype level. In-silico functional mapping shows a functional relationship of these five genes with WNT5A, suggesting that Wnt pathway disruption may play a role in BPD pathogenesis.
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- 2021
47. Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown
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Rasmussen, Marie Isabel, Hansen, Mathias Lühr, Pichler, Gerhard, Dempsey, Eugene, Pellicer, Adelina, EL-Khuffash, Afif, A, Shashidhar, Piris-Borregas, Salvador, Alsina, Miguel, Cetinkaya, Merih, Chalak, Lina, Özkan, Hilal, Baserga, Mariana, Sirc, Jan, Fuchs, Hans, Ergenekon, Ebru, Arruza, Luis, Mathur, Amit, Stocker, Martin, Otero Vaccarello, Olalla, Szczapa, Tomasz, Sarafidis, Kosmas, Królak-Olejnik, Barbara, Memisoglu, Asli, Reigstad, Hallvard, Rafińska-Ważny, Elżbieta, Hatzidaki, Eleftheria, Peng, Zhang, Gkentzi, Despoina, Viellevoye, Renaud, De Buyst, Julie, Mastretta, Emmanuele, Wang, Ping, Hahn, Gitte Holst, Bender, Lars, Cornette, Luc, Tkaczyk, Jakub, del Rio, Ruth, Fumagalli, Monica, Papathoma, Evangelia, Wilinska, Maria, Naulaers, Gunnar, Sadowska-Krawczenko, Iwona, Lecart, Chantal, Couce, María Luz, Fredly, Siv, Heuchan, Anne Marie, Karen, Tanja, Greisen, Gorm, Rasmussen, Marie Isabel, Hansen, Mathias Lühr, Pichler, Gerhard, Dempsey, Eugene, Pellicer, Adelina, EL-Khuffash, Afif, A, Shashidhar, Piris-Borregas, Salvador, Alsina, Miguel, Cetinkaya, Merih, Chalak, Lina, Özkan, Hilal, Baserga, Mariana, Sirc, Jan, Fuchs, Hans, Ergenekon, Ebru, Arruza, Luis, Mathur, Amit, Stocker, Martin, Otero Vaccarello, Olalla, Szczapa, Tomasz, Sarafidis, Kosmas, Królak-Olejnik, Barbara, Memisoglu, Asli, Reigstad, Hallvard, Rafińska-Ważny, Elżbieta, Hatzidaki, Eleftheria, Peng, Zhang, Gkentzi, Despoina, Viellevoye, Renaud, De Buyst, Julie, Mastretta, Emmanuele, Wang, Ping, Hahn, Gitte Holst, Bender, Lars, Cornette, Luc, Tkaczyk, Jakub, del Rio, Ruth, Fumagalli, Monica, Papathoma, Evangelia, Wilinska, Maria, Naulaers, Gunnar, Sadowska-Krawczenko, Iwona, Lecart, Chantal, Couce, María Luz, Fredly, Siv, Heuchan, Anne Marie, Karen, Tanja, and Greisen, Gorm
- Abstract
Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28 weeks of gestational age) differed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: (1) Total number of EP infant admissions to their NICU in the 3 months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, (2) Similar EP infant admissions in the corresponding 3 months of 2019, (3) the level of local restrictions during the lockdown period, and (4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: The number of EP infant admissions during the first wave of the COVID-19 pandemic was 428 compared to 457 in the corresponding 3 months in 2019 (−6.6%, 95% CI −18.2 to +7.1%, p = 0.33). There were no statistically significant differences within individual geographic regions and no significant association between the level of lockdown restrictions and difference in the number of EP infant admissions. A post-hoc analysis based on data from the 46 NICUs found a decrease of 10.3%in the total number of NICU admissions (n = 7,499 in 2020 vs. n = 8,362 in 2019). Conclusion: This ad hoc study did not confirm previous reports of a major reduction in the number of extremely pretermbirths during the first phase of the COVID-19 pandemic. Clinical Trial Registration: ClinicalTrial.gov, identifier: NCT04527601 (registered August 26, 2020), https://clinicaltrials.gov/ct2/show/NCT04527601.
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- 2021
48. Culture-proven neonatal sepsis in preterm infants in a neonatal intensive care unit over a 7 year period: Coagulase-negative Staphylococcus as the predominant pathogen
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Ozkan, Hilal, Cetinkaya, Merih, Koksal, Nilgün, Celebi, Solmaz, and Hacmustafaoglu, Mustafa
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- 2014
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49. Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study
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Ozkan, Hilal, additional, Cetinkaya, Merih, additional, Cakir, Salih C., additional, Saglam, Ozge, additional, and Koksal, Nilgun, additional
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- 2021
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50. SIMPLE: A Novel Scoring System for Predicting Hemodynamically Significant Patent Ductus Arteriosus Without Echocardiographic Evaluation in Extremely Low Birth Weight Infants
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Gonen, Ilker, primary, Babayigit, Aslan, additional, Bornaun, Helen, additional, Yasa, Beril, additional, Memur, Seyma, additional, Semerci, Seda Yilmaz, additional, and Cetinkaya, Merih, additional
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- 2021
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