Back to Search
Start Over
Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury
- Source :
- Canadian Journal of Physiology and Pharmacology. February, 2023, Vol. 101 Issue 2, p65, 9 p.
- Publication Year :
- 2023
-
Abstract
- Antenatal steroid administration to pregnant women at risk of prematurity provides pulmonarymaturation in infants, while it has limited effects on incidence of bronchopulmonary dysplasia (BPD), the clinical expression of hyperoxia-induced lung injury (HILI). Cytidine-5'-diphosphate choline (CDP-choline) was shown to alleviate HILI when administered to newborn rats. Therefore, we investigated effects of maternal administration of CDP-choline, alone or in combination with betamethasone, on lung maturation in neonatal rats subjected to HILI immediately after birth. Pregnant rats were randomly assigned to one of the four treatments: saline (1mL/kg), CDP-choline (300 mg/kg), betamethasone (0.4mg/kg), or CDP-choline plus betamethasone (combination therapy). From postnatal day 1 to 11, pups born to mothers in the same treatment group were pooled and randomly assigned to either normoxia or hyperoxia group. Biochemical an d histopathological effects of CDP-choline on neonatal lung tissue were evaluated. Antenatal CDP-choline treatment increased levels of phosphatidylcholine and total lung phospholipids, decreased apoptosis, and improved alveolarization. The outcomes were further improved with combination therapy compared to the administration of CDP-choline or betamethasone alone. These results demonstrate that antenatal CDP-choline treatment provides benefit in experimental HILI either alone or more intensively when administered along with a steroid, suggesting a possible utility for CDP-choline against BPD. Key words: betamethasone, bronchopulmonary dysplasia, citicoline, newborn rat<br />1. Introduction Bronchopulmonary dysplasia (BPD) is the most common long-term respiratory complication of premature birth. Despite improvements such as antenatal corticosteroid therapy, non-invasive ventilation practices, surfactant replacement therapy, and advanced [...]
Details
- Language :
- English
- ISSN :
- 00084212
- Volume :
- 101
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.737543358
- Full Text :
- https://doi.org/10.1139/cjpp-2022-0321