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2. Valorization of By-Products from Biofuel Biorefineries: Extraction and Purification of Bioactive Molecules from Post-Fermentation Corn Oil

Author

Cairone, F., Cesa, S, Ciogli, A., Fabrizi, G, Goggiamani, A., Iazzetti, Antonia, Di Lena, G., Sanchez Del Pulgar, J., Lucarini, M., Cantò, L., Zengin, G., Ondrejíčková, P., Cairone F., Cesa S, Ciogli A., Fabrizi G, Goggiamani A., Iazzetti A. (ORCID:0000-0002-7792-774X), Di Lena G., Sanchez Del Pulgar J., Lucarini M., Cantò L., Zengin G., Ondrejíčková P., Cairone, F., Cesa, S, Ciogli, A., Fabrizi, G, Goggiamani, A., Iazzetti, Antonia, Di Lena, G., Sanchez Del Pulgar, J., Lucarini, M., Cantò, L., Zengin, G., Ondrejíčková, P., Cairone F., Cesa S, Ciogli A., Fabrizi G, Goggiamani A., Iazzetti A. (ORCID:0000-0002-7792-774X), Di Lena G., Sanchez Del Pulgar J., Lucarini M., Cantò L., Zengin G., and Ondrejíčková P.

Abstract

The aim of this work was to develop innovative and sustainable extraction, concentration, and purification technologies aimed to recover target substances from corn oil, obtained as side stream product of biomass refineries. Residues of bioactive compounds such as carotenoids, phytosterols, tocopherols, and polyphenols could be extracted from this matrix and applied as ingredients for food and feeds, nutraceuticals, pharmaceuticals, and cosmetic products. These molecules are well known for their antioxidant and antiradical capacity, besides other specific biological activities, generically involved in the prevention of chronic and degenerative diseases. The project involved the development of methods for the selective extraction of these minor components, using as suitable extraction technique solid phase extraction. All the extracted and purified fractions were evaluated by NMR spectroscopic analyses and UV–Vis spectrophotometric techniques and characterized by quali-quantitative HPLC analyses. TPC (total phenolic content) and TFC (total flavonoid content) were also determined. DPPH and ABTS radical were used to evaluate radical quenching abilities. Acetylcholinesterase (AChE), amylase, glucosidase, and tyrosinase were selected as enzymes in the enzyme inhibitory assays. The obtained results showed the presence of a complex group of interesting molecules with strong potential in market applications according to circular economy principles.

Published
2022

4. Valorisation of Side Stream Products through Green Approaches: The Rapeseed Meal Case

Author

Cairone, F., Allevi, Dario, Cesa, S., Fabrizi, G., Goggiamani, Antonella, Masci, Domiziana, Iazzetti, Antonia, Allevi D. (ORCID:0000-0002-0188-9505), Goggiamani A., Masci D. (ORCID:0000-0002-5615-5111), Iazzetti A. (ORCID:0000-0002-7792-774X), Cairone, F., Allevi, Dario, Cesa, S., Fabrizi, G., Goggiamani, Antonella, Masci, Domiziana, Iazzetti, Antonia, Allevi D. (ORCID:0000-0002-0188-9505), Goggiamani A., Masci D. (ORCID:0000-0002-5615-5111), and Iazzetti A. (ORCID:0000-0002-7792-774X)

Abstract

Rapeseed meal (RSM) is a by-product of rapeseed oil extraction and is a rich source of bioactive compounds, including proteins and antioxidants. This study compared two methods for extracting antioxidants from RSM: conventional ethanol Soxhlet extraction and supercritical CO2 extraction. These procedures were applied to both native RSM and RSM after protein removal to evaluate their bio-compound composition and potential applications. HPLC-DAD, NMR, and GC/MS analyses revealed a rich polyphenolic profile in the extracts, including the presence of sinapic acid. The concentration of sinapic acid varied depending on the extraction method used. The anti-radical activity of the extracts was also analysed using the DPPH assay, which confirmed the potential of RSM as a source of antioxidants for use in cosmetics, food, and pharmaceutical formulations.

Published
2023

5. In-Depth Chemical Characterization of Punica granatum L. Seed Oil

Author

Cairone, F., Salvitti, C., Iazzetti, Antonia, Fabrizi, G., Troiani, A., Pepi, F., Cesa, S., Iazzetti A. (ORCID:0000-0002-7792-774X), Cairone, F., Salvitti, C., Iazzetti, Antonia, Fabrizi, G., Troiani, A., Pepi, F., Cesa, S., and Iazzetti A. (ORCID:0000-0002-7792-774X)

Abstract

Fruit seeds belonging to the pomegranate cultivar "Granata" were subjected to extraction and oily component analysis, with the aim of obtaining information about their composition. The presence of conjugated isomers of linolenic acid (CLNA isomers) in the oily phase extracted from the seeds gives a high added value to this part of the fruit, which is too often considered and treated as waste. The separated seeds were subjected to a classic Soxhlet extraction with n-hexane or extraction with supercritical CO2, assisted by ethanol. The resulting oils were evaluated by H-1 and C-13-NMR and AP-MALDI-MS techniques. Differences in the triacylglycerols composition, with particular regard to punicic acid and other CLNA content, were studied in depth. Results showed the prevalence of punicic acid in the triacylglycerol mixture up to the 75%, with clear preponderance in the extract by supercritical fluids. Consequently, other CLNA isomers are, altogether, two-fold less represented in the supercritical extract than in the Soxhlet one. The two oily residues were subjected to solid phase extraction (SPE) and to HPLC-DAD analysis for the polyphenolic isolation and characterization. In addition to HPLC analysis, which showed different content and composition, DPPH analysis to evaluate the antiradical potential showed that the extract obtained with supercritical CO2 was much more active.

Published
2023

8. Preparing for future waves and pandemics: a global hospital survey on infection control measures and infection rates in COVID-19

Author

Matoori, S, Kuritzkes, D, Goh, Y, Quek, S, Wang, L, Sun, Z, di Marco, F, Borleri, D, Buoro, S, Fagiuoli, S, Ferrari, T, Rizzi, M, Raimondi, F, Cesa, S, Koh, D, Froehlich, J, Janssen, S, Lange, B, Egle, A, Erb, S, Mossdorf, E, Gutzeit, A, Matoori S., Kuritzkes D. R., Goh Y., Quek S. T., Wang L., Sun Z., di Marco F., Borleri D., Buoro S., Fagiuoli S., Ferrari T., Rizzi M., Raimondi F., Cesa S., Koh D. -M., Froehlich J. M., Janssen S., Lange B., Egle A., Erb S., Mossdorf E., Gutzeit A., Matoori, S, Kuritzkes, D, Goh, Y, Quek, S, Wang, L, Sun, Z, di Marco, F, Borleri, D, Buoro, S, Fagiuoli, S, Ferrari, T, Rizzi, M, Raimondi, F, Cesa, S, Koh, D, Froehlich, J, Janssen, S, Lange, B, Egle, A, Erb, S, Mossdorf, E, Gutzeit, A, Matoori S., Kuritzkes D. R., Goh Y., Quek S. T., Wang L., Sun Z., di Marco F., Borleri D., Buoro S., Fagiuoli S., Ferrari T., Rizzi M., Raimondi F., Cesa S., Koh D. -M., Froehlich J. M., Janssen S., Lange B., Egle A., Erb S., Mossdorf E., and Gutzeit A.

Abstract

A survey of hospitals on three continents was performed to assess their infection control preparedness and measures, and their infection rate in hospital health care workers during the COVID-19 pandemic. All surveyed hospitals used similar PPE but differences in preparedness, PPE shortages, and infection rates were reported.

Published
2021

9. Covid-19 and gender: lower rate but same mortality of severe disease in women-an observational study

Author

Raimondi, F, Novelli, L, Ghirardi, A, Russo, F, Pellegrini, D, Biza, R, Trapasso, R, Giuliani, L, Anelli, M, Amoroso, M, Allegri, C, Imeri, G, Sanfilippo, C, Comandini, S, Hila, E, Manesso, L, Gandini, L, Mandelli, P, Monti, M, Gori, M, Senni, M, Lorini, F, Rizzi, M, Barbui, T, Paris, L, Rambaldi, A, Cosentini, R, Guagliumi, G, Cesa, S, Colledan, M, Sessa, M, Masciulli, A, Gavazzi, A, Buoro, S, Remuzzi, G, Ruggenenti, P, Callegaro, A, Gianatti, A, Farina, C, Bellasi, A, Sironi, S, Fagiuoli, S, Di Marco, F, Raimondi F, Novelli L, Ghirardi A, Russo FM, Pellegrini D, Biza R, Trapasso R, Giuliani L, Anelli M, Amoroso M, Allegri C, Imeri G, Sanfilippo C, Comandini S, Hila E, Manesso L, Gandini L, Mandelli P, Monti M, Gori M, Senni M, Lorini FL, Rizzi M, Barbui T, Paris L, Rambaldi A, Cosentini R, Guagliumi G, Cesa S, Colledan M, Sessa M, Masciulli A, Gavazzi A, Buoro S, Remuzzi G, Ruggenenti P, Callegaro A, Gianatti A, Farina C, Bellasi A, Sironi S, Fagiuoli S, Di Marco F, Raimondi, F, Novelli, L, Ghirardi, A, Russo, F, Pellegrini, D, Biza, R, Trapasso, R, Giuliani, L, Anelli, M, Amoroso, M, Allegri, C, Imeri, G, Sanfilippo, C, Comandini, S, Hila, E, Manesso, L, Gandini, L, Mandelli, P, Monti, M, Gori, M, Senni, M, Lorini, F, Rizzi, M, Barbui, T, Paris, L, Rambaldi, A, Cosentini, R, Guagliumi, G, Cesa, S, Colledan, M, Sessa, M, Masciulli, A, Gavazzi, A, Buoro, S, Remuzzi, G, Ruggenenti, P, Callegaro, A, Gianatti, A, Farina, C, Bellasi, A, Sironi, S, Fagiuoli, S, Di Marco, F, Raimondi F, Novelli L, Ghirardi A, Russo FM, Pellegrini D, Biza R, Trapasso R, Giuliani L, Anelli M, Amoroso M, Allegri C, Imeri G, Sanfilippo C, Comandini S, Hila E, Manesso L, Gandini L, Mandelli P, Monti M, Gori M, Senni M, Lorini FL, Rizzi M, Barbui T, Paris L, Rambaldi A, Cosentini R, Guagliumi G, Cesa S, Colledan M, Sessa M, Masciulli A, Gavazzi A, Buoro S, Remuzzi G, Ruggenenti P, Callegaro A, Gianatti A, Farina C, Bellasi A, Sironi S, Fagiuoli S, and Di Marco F

Abstract

Background Gender-related factors might affect vulnerability to Covid-19. The aim of this study was to describe the role of gender on clinical features and 28-day mortality in Covid-19 patients. Methods Observational study of Covid-19 patients hospitalized in Bergamo, Italy, during the first three weeks of the outbreak. Medical records, clinical, radiological and laboratory findings upon admission and treatment have been collected. Primary outcome was 28-day mortality since hospitalization. Results 431 consecutive adult patients were admitted. Female patients were 119 (27.6%) with a mean age of 67.0 +/- 14.5 years (vs 67.8 +/- 12.5 for males, p = 0.54). Previous history of myocardial infarction, vasculopathy and former smoking habits were more common for males. At the time of admission PaO2/FiO(2) was similar between men and women (228 [IQR, 134-273] vs 238 mmHg [150-281], p = 0.28). Continuous Positive Airway Pressure (CPAP) assistance was needed in the first 24 h more frequently in male patients (25.7% vs 13.0%; p = 0.006). Overall 28-day mortality was 26.1% in women and 38.1% in men (p = 0.018). Gender did not result an independent predictor of death once the parameters related to disease severity at presentation were included in the multivariable analysis (p = 0.898). Accordingly, the Kaplan-Meier survival analysis in female and male patients requiring CPAP or non-invasive ventilation in the first 24 h did not find a significant difference (p = 0.687). Conclusion Hospitalized women are less likely to die from Covid-19; however, once severe disease occurs, the risk of dying is similar to men. Further studies are needed to better investigate the role of gender in clinical course and outcome of Covid-19.

Published
2021

19. Surviving COVID-19 in Bergamo province: a post-acute outpatient re-evaluation

Author

Venturelli, S, Benatti, S, Casati, M, Binda, F, Zuglian, G, Imeri, G, Conti, C, Biffi, A, Spada, M, Bondi, E, Camera, G, Severgnini, R, Giammarresi, A, Marinaro, C, Rossini, A, Bonaffini, P, Guerra, G, Bellasi, A, Cesa, S, Rizzi, M, Venturelli, Serena, Benatti, Simone Vasilij, Casati, Monica, Binda, Francesca, Zuglian, Gianluca, Imeri, Gianluca, Conti, Caterina, Biffi, Ave Maria, Spada, Maria Simonetta, Bondi, Emi, Camera, Giorgia, Severgnini, Roberta, Giammarresi, Andrea, Marinaro, Claudia, Rossini, Alessandro, Bonaffini, Pietro Andrea, Guerra, Giovanni, Bellasi, Antonio, Cesa, Simonetta, Rizzi, Marco, Venturelli, S, Benatti, S, Casati, M, Binda, F, Zuglian, G, Imeri, G, Conti, C, Biffi, A, Spada, M, Bondi, E, Camera, G, Severgnini, R, Giammarresi, A, Marinaro, C, Rossini, A, Bonaffini, P, Guerra, G, Bellasi, A, Cesa, S, Rizzi, M, Venturelli, Serena, Benatti, Simone Vasilij, Casati, Monica, Binda, Francesca, Zuglian, Gianluca, Imeri, Gianluca, Conti, Caterina, Biffi, Ave Maria, Spada, Maria Simonetta, Bondi, Emi, Camera, Giorgia, Severgnini, Roberta, Giammarresi, Andrea, Marinaro, Claudia, Rossini, Alessandro, Bonaffini, Pietro Andrea, Guerra, Giovanni, Bellasi, Antonio, Cesa, Simonetta, and Rizzi, Marco

Abstract

Bergamo province was badly hit by the coronavirus disease 2019 (COVID-19) epidemic. We organised a public-funded, multidisciplinary follow-up programme for COVID-19 patients discharged from the emergency department or from the inpatient wards of 'Papa Giovanni XXIII' Hospital, the largest public hospital in the area. As of 31 July, the first 767 patients had completed the first post-discharge multidisciplinary assessment. Patients entered our programme at a median time of 81 days after discharge. Among them, 51.4% still complained of symptoms, most commonly fatigue and exertional dyspnoea, and 30.5% were still experiencing post-traumatic psychological consequences. Impaired lung diffusion was found in 19%. Seventeen per cent had D-dimer values two times above the threshold for diagnosis of pulmonary embolism (two unexpected and clinically silent pulmonary thrombosis were discovered by investigating striking D-dimer elevation). Survivors of COVID-19 exhibit a complex array of symptoms, whose common underlying pathology, if any, has still to be elucidated: a multidisciplinary approach is fundamental, to address the different problems and to look for effective solutions.

Published
2021

20. Phytocomplex Characterization and Biological Evaluation of Powdered Fruits and Leaves from Elaeagnus angustifolia

Author

Carradori, S., Cairone, F., Garzoli, S., Fabrizi, G., Iazzetti, Antonia, Giusti, A. M., Menghini, L., Uysal, S., Ak, G., Zengin, G., Cesa, S., Iazzetti A. (ORCID:0000-0002-7792-774X), Carradori, S., Cairone, F., Garzoli, S., Fabrizi, G., Iazzetti, Antonia, Giusti, A. M., Menghini, L., Uysal, S., Ak, G., Zengin, G., Cesa, S., and Iazzetti A. (ORCID:0000-0002-7792-774X)

Abstract

Fully ripe fruits and mature leaves of Elaeagnus angustifolia were harvested and analyzed by means of analytical and biological tests to better comprehend the chemical composition and therapeutic/nutraceutical potential of this plant. Fruits and leaves were dried and the obtained powders were analyzed to study their color character and (via headspace gas chromatography) describe the chemical profile. Subsequently, they were submitted to a chloroform–methanol extraction, to a hydroalcoholic extraction procedure assisted or not by microwaves, and to an extraction with supercritical CO2, assisted or not by ethanol as the co-solvent, to detect the polyphenolic and the volatile content. The resulting extracts were evaluated in terms of chlorophyll and carotenoid content, polyphenolic content, volatile fraction, total phenolic content, total flavonoid content, antioxidant activity, radical scavenging activity, and enzymatic inhibition activity. The results confirmed the correlation between the chemical composition and the high antioxidant potential of leaf extracts compared to the fruit extracts in terms of the phenolic and pigment content. A promising effect against tyrosinase emerged for all the extracts, suggesting a therapeutic/nutraceutical use for this plant. Conversely, the volatile content from both natural matrices was similar.

Published
2020

27. 6. Lipidi

Author

Mulinacci, N., Innocenti, M., Cossignani, L., Blasi, F., Montesano, D., Dugo, G., Saitta, M., Cicero, N., Di Bella, G., Mannina, L., Sobolev, A. P., Cesa, S., Casini, A., Ingallina, C., and Salvo, A.

Subjects
la chimica e gli alimenti, nutrienti e aspetti nutraceutici
Published
2019

28. 7. Alimenti lipidici

Author

Mulinacci, N., Innocenti, M., Cossignani, L., Blasi, F., Montesano, D., Dugo, G., Saitta, M., Cicero, N., Di Bella, G., Mannina, L., Sobolev, A. P., Cesa, S., Casini, A., Ingallina, C., and Salvo, A.

Subjects
la chimica e gli alimenti, nutrienti e aspetti nutraceutici, Burro, Olio d'oliva, Oli di semi, Burro, Acido butirrico, Margarina, Margarina, Acido butirrico, Olio d'oliva, Oli di semi
Published
2019

29. Monitoraggio degli esiti sensibili dell’assistenza: la contenzione fisica della persona adulta nella media intensità di cura ospedaliera

Author

Gatti, M, Casati, M, DI MAURO, S, Pellegrini, R, Cesa, S, Marchesi, M, Marco Gatti, Monica Casati, Stefania Di Mauro, Ramona Pellegrini, Simonetta Cesa, Matteo Marchesi, Gatti, M, Casati, M, DI MAURO, S, Pellegrini, R, Cesa, S, Marchesi, M, Marco Gatti, Monica Casati, Stefania Di Mauro, Ramona Pellegrini, Simonetta Cesa, and Matteo Marchesi

Abstract

Introduction Physical restraint is an extraordinary nursing act that poses ethical, nursing, deontological and legal issues. Literature shows weak evidence to support it, despite its frequent use in clinical practice. Prevalence monitoring is recommended, even if the evaluations are uneven due to different characteristics of the settings of care and whether bedrails are included among physical restraints or not. The objective of this study is to assess the prevalence of physical restraint in the Italian health system, through its evaluation in the Papa Giovanni XXIII hospital, Bergamo. Methods Observational, prospective study. All in-patients undergoing physical restraint were assessed along an observation period lasting 51 consecutive days and involving 21 continuous-cycle hospital care units. The critical area, the paediatric area and the mental health area were excluded. Daily surveys, direct observations of the patients contained and analysis of the clinical documentation have been carried out. Results The different methods of investigation used indicate a prevalence of containment of 2.13% (daily surveys) and 1.5% (direct observations).

Published
2019

33. Phytochemical analyses and pharmacological screening of Neem oil

Author

Cesa, S., primary, Sisto, F., additional, Zengin, G., additional, Scaccabarozzi, D., additional, Kokolakis, A.K., additional, Scaltrito, M.M., additional, Grande, R., additional, Locatelli, M., additional, Cacciagrano, F., additional, Angiolella, L., additional, Campestre, C., additional, Granese, A., additional, Chimenti, P., additional, and Basilico, N., additional

Published
2019
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36. Abnormal resting state functional connectivity of the periaqueductal grey in patients with fibromyalgia

Author

Truini, A., Tinelli, E., Gerardi, M. C., Calistri, V., Iannuccelli, C., La Cesa, S., Tarsitani, L., Mainero, C., Sarzi-Puttini, P., Cruccu, G., Francesca CARAMIA, and Di Franco, M.

Subjects
Adult, Male, Settore MED/16 - Reumatologia, Brain Mapping, fMRI, fibromyalgia, pain, Fibromyalgia, Humans, Periaqueductal Gray, Female, Chronic Pain, Middle Aged, Magnetic Resonance Imaging
Abstract

Emerging evidence associates chronic pain syndrome, such as fibromyalgia, with endogenous pain modulatory system dysfunction, leading to an impaired descending pain inhibition. In this study, using resting-state functional magnetic resonance imaging (fMRI), we aimed at seeking possible functional connectivity changes of the periaqueductal gray (PAG), a brainstem area that belongs to the endogenous pain modulatory system, in patients with fibromyalgia.In 20 patients with fibromyalgia and 15 healthy subjects, we investigated PAG functional connectivity using resting-state fMRI. We also analysed the correlation between clinical variables, such as pain severity, disease duration, and depressive personality traits with PAG functional connectivity.Compared with control subjects, we identified that patients with fibromyalgia had an increased PAG connectivity with insula, anterior cingulate cortex, and anterior prefrontal cortex. The functional connectivity between PAG and the rostral ventral medulla, however, was not concordantly increased. PAG functional connectivity correlated with pain severity, disease duration, and the depressive personality trait rating.Our fMRI study showing abnormal resting state functional connectivity of the PAG suggests that patients with fibromyalgia have an endogenous pain modulatory system dysfunction, possibly causing an impaired descending pain inhibition. This abnormal PAG functioning might underlay the chronic pain these patients suffer from.

Published
2016

44. Tools to differentiate medium-high versus medium low-care intensity in an Internal Medecine Unit

Author

Mangia, M, Casati, M, Carobbio, A, Caldara, R, Morandi, I, Cattaneo, M, Senni, M, Pagani, G, Ghidoni, S, Tiraboschi, P, Galbiati, G, Capelli, C, Tomasoni, L, Cesa, S, Brucato, A, Mangia M, Casati M, Carobbio A, Caldara R, Morandi I, Cattaneo M, Senni M, Pagani G, Ghidoni S, Tiraboschi P, Galbiati G, Capelli C, Tomasoni L, Cesa S, Brucato A, Mangia, M, Casati, M, Carobbio, A, Caldara, R, Morandi, I, Cattaneo, M, Senni, M, Pagani, G, Ghidoni, S, Tiraboschi, P, Galbiati, G, Capelli, C, Tomasoni, L, Cesa, S, Brucato, A, Mangia M, Casati M, Carobbio A, Caldara R, Morandi I, Cattaneo M, Senni M, Pagani G, Ghidoni S, Tiraboschi P, Galbiati G, Capelli C, Tomasoni L, Cesa S, and Brucato A

Published
2011

45. Cooling the skin for assessing small-fibre function.

Author

Leone, Caterina, Dufour, Andre, Di Stefano, Giulia, Fasolino, Alessandra, Di Lionardo, Andrea, La Cesa, Silvia, Galosi, Eleonora, Valeriani, Massimiliano, Nolano, Maria, Cruccu, Giorgio, Truini, Andrea, Leone, C, Dufour, A, Di Stefano, G, Fasolino, A, Di Lionardo, A, La Cesa, S, Galosi, E, Valeriani, M, and Nolano, M

Published
2019
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46. Time for a Consensus Conference on pain in neurorehabilitation

Author

Sandrini, Giorgio, Tamburin, Stefano, Paolucci, Stefano, Boldrini, Paolo, Saraceni, Vincenzo M, Smania, Nicola, Agostini, M, Alfonsi, E, Aloisi, Am, Alvisi, E, Aprile, I, Armando, M, Avenali, M, Azicnuda, E, Barale, F, Bartolo, M, Bergamaschi, R, Berlangieri, M, Berlincioni, V, Berliocchi, L, Berra, E, Berto, G, Bonadiman, S, Bonazza, S, Bressi, F, Brugnera, A, Brunelli, S, Buzzi, Mg, Cacciatori, C, Calvo, A, Cantarella, C, Caraceni, At, Carone, R, Carraro, E, Casale, R, Castellazzi, P, Castelnuovo, G, Castino, A, Cella, M, Cerbo, R, Chiò, A, Ciotti, C, Cisari, C, Coraci, D, Dalla Toffola, E, Defazio, G, De Icco, R, Del Carro, U, Dell’Isola, A, De Tanti, A, D’Ippolito, M, Fazzi, E, Federico, A, Ferrari, A, Ferrari, S, Ferraro, F, Formaglio, F, Formisano, R, Franzoni, S, Gajofatto, F, Gandolfi, M, Gardella, B, Geppetti, P, Giammò, A, Gimigliano, R, Giusti, Em, Greco, E, Ieraci, V, Invernizzi, M, Jacopetti, M, Jedrychowska, I, Lacerenza, M, La Cesa, S, Lobba, D, Magrinelli, F, Mandrini, S, Manera, U, Manzoni, Gm, Marchettini, P, Marchioni, E, Mariotto, S, Martinuzzi, A, Masciullo, M, Mezzarobba, S, Miotti, D, Modenese, A, Molinari, M, Monaco, S, Morone, G, Nappi, R, Negrini, S, Pace, A, Padua, L, Pagliano, E, Palmerini, V, Paolucci, S, Pazzaglia, C, Pecchioli, C, Pietrabissa, G, Picelli, A, Polli, A, Porro, Ca, Porru, D, Romano, M, Roncari, L, Rosa, R, Saccavini, M, Sacerdote, P, Sandrini, G, Saviola, D, Schenone, A, Schweiger, V, Scivoletto, G, Smania, N, Solaro, C, Spallone, V, Springhetti, I, Tamburin, S, Tassorelli, C, Tinazzi, M, Togni, R, Torre, M, Torta, R, Traballesi, M, Trabucco, E, Tramontano, M, Truini, A, Tugnoli, V, Turolla, A, Valeriani, M, Vallies, G, Verzini, E, Vottero, M, Mario, P., Castelnuovo G (ORCID:0000-0003-2633-9822), Giusti EM (ORCID:0000-0001-5767-8785), Padua L (ORCID:0000-0003-2570-9326), Pietrabissa G (ORCID:0000-0002-5911-5748), Sandrini, Giorgio, Tamburin, Stefano, Paolucci, Stefano, Boldrini, Paolo, Saraceni, Vincenzo M, Smania, Nicola, Agostini, M, Alfonsi, E, Aloisi, Am, Alvisi, E, Aprile, I, Armando, M, Avenali, M, Azicnuda, E, Barale, F, Bartolo, M, Bergamaschi, R, Berlangieri, M, Berlincioni, V, Berliocchi, L, Berra, E, Berto, G, Bonadiman, S, Bonazza, S, Bressi, F, Brugnera, A, Brunelli, S, Buzzi, Mg, Cacciatori, C, Calvo, A, Cantarella, C, Caraceni, At, Carone, R, Carraro, E, Casale, R, Castellazzi, P, Castelnuovo, G, Castino, A, Cella, M, Cerbo, R, Chiò, A, Ciotti, C, Cisari, C, Coraci, D, Dalla Toffola, E, Defazio, G, De Icco, R, Del Carro, U, Dell’Isola, A, De Tanti, A, D’Ippolito, M, Fazzi, E, Federico, A, Ferrari, A, Ferrari, S, Ferraro, F, Formaglio, F, Formisano, R, Franzoni, S, Gajofatto, F, Gandolfi, M, Gardella, B, Geppetti, P, Giammò, A, Gimigliano, R, Giusti, Em, Greco, E, Ieraci, V, Invernizzi, M, Jacopetti, M, Jedrychowska, I, Lacerenza, M, La Cesa, S, Lobba, D, Magrinelli, F, Mandrini, S, Manera, U, Manzoni, Gm, Marchettini, P, Marchioni, E, Mariotto, S, Martinuzzi, A, Masciullo, M, Mezzarobba, S, Miotti, D, Modenese, A, Molinari, M, Monaco, S, Morone, G, Nappi, R, Negrini, S, Pace, A, Padua, L, Pagliano, E, Palmerini, V, Paolucci, S, Pazzaglia, C, Pecchioli, C, Pietrabissa, G, Picelli, A, Polli, A, Porro, Ca, Porru, D, Romano, M, Roncari, L, Rosa, R, Saccavini, M, Sacerdote, P, Sandrini, G, Saviola, D, Schenone, A, Schweiger, V, Scivoletto, G, Smania, N, Solaro, C, Spallone, V, Springhetti, I, Tamburin, S, Tassorelli, C, Tinazzi, M, Togni, R, Torre, M, Torta, R, Traballesi, M, Trabucco, E, Tramontano, M, Truini, A, Tugnoli, V, Turolla, A, Valeriani, M, Vallies, G, Verzini, E, Vottero, M, Mario, P., Castelnuovo G (ORCID:0000-0003-2633-9822), Giusti EM (ORCID:0000-0001-5767-8785), Padua L (ORCID:0000-0003-2570-9326), and Pietrabissa G (ORCID:0000-0002-5911-5748)

Abstract

Time for a Consensus Conference on pain in neurorehabilitation.

Published
2016

47. Tools to differentiate medium-high versus medium low-care intensity in an Internal Medecine Unit

Author

Mangia M, Casati M, Carobbio A, Caldara R, Morandi I, Cattaneo M, Senni M, Pagani G, Ghidoni S, Tiraboschi P, Galbiati G, Capelli C, Tomasoni L, Cesa S, Brucato A, Mangia, M, Casati, M, Carobbio, A, Caldara, R, Morandi, I, Cattaneo, M, Senni, M, Pagani, G, Ghidoni, S, Tiraboschi, P, Galbiati, G, Capelli, C, Tomasoni, L, Cesa, S, and Brucato, A

Subjects
Internal Medecine
Published
2011

48. How to diagnose neuropathic pain? The contribution from clinical examination, pain questionnaires and diagnostic tests.

Author

Cesa, S., Tamburin, S., Tugnoli, V., Sandrini, G., Paolucci, S., Lacerenza, M., Marchettini, P., Cruccu, G., Truini, A., and La Cesa, S

Subjects
*NEUROPATHY, *PAIN management, *MEDICAL screening, *QUESTIONNAIRES, *NONINVASIVE diagnostic tests, *DIAGNOSIS, *NEURALGIA, *DIFFERENTIAL diagnosis, *PHYSICAL diagnosis, *PAIN measurement, *ROUTINE diagnostic tests
Abstract

Patients with peripheral and central nervous system diseases may suffer from different types of pain, namely nociceptive, neuropathic and mixed pain. Although in some cases, the distinction between these types of pain is clinically evident, yet in some patients an accurate differential diagnosis requires dedicated clinical examination, screening questionnaires and diagnostic techniques some of which are available only in specialized pain centres. This review briefly addresses the currently agreed definitions of the different types of pain and shows how clinical examination, pain questionnaires and diagnostic tests can help the clinicians in identifying neuropathic pain. [ABSTRACT FROM AUTHOR]

Published
2015
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