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694 results on '"Centre for Cancer Genetic Epidemiology"'

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1. Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

2. Polygenic risk modeling for prediction of epithelial ovarian cancer risk

3. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

4. Alcohol consumption, cigarette smoking, and risk of breast cancer for BRCA1 and BRCA2 mutation carriers: results from The BRCA1 and BRCA2 Cohort Consortium

5. The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

6. The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations

7. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

8. The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

9. Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

10. Incorporating alternative Polygenic Risk Scores into the BOADICEA breast cancer risk prediction model

11. Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

12. Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores

13. Discovery of common and rare genetic risk variants for colorectal cancer

14. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

15. Shared heritability and functional enrichment across six solid cancers

16. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

17. Shared heritability and functional enrichment across six solid cancers

18. Clinicians' use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey

19. Germline variation at 8q24 and prostate cancer risk in men of European ancestry

20. Improved outcome of 131 I-mIBG treatment through combination with external beam radiotherapy in the SK-N-SH mouse model of neuroblastoma

21. Expression atlas and comparative coexpression network analyses reveal important genes involved in the formation of lignified cell wall in Brachypodium distachyon

22. A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

23. Prevalence and covariates of electrocardiographic left ventricular hypertrophy in the Hypertension in the Very Elderly Trial

24. Combined genetic and splicing analysis of BRCA1 c.[594-2A > C; 641A > G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms

25. Biomechanical evolution of solid bones in large animals: a microanatomical investigation

26. Exploring the link between MORF4L1 and risk of breast cancer

27. Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers

28. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

29. Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers

30. Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

31. Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers

32. Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

33. Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

34. Protein-truncating and rare missense variants in ATM and CHEK2 and associations with cancer in UK Biobank whole-exome sequence data.

35. Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study.

36. Polygenic risk scores stratify breast cancer risk among women with benign breast disease.

37. Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2.

38. Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank.

39. Epigenome-Wide Association Studies of Chronic Obstructive Pulmonary Disease and Lung Function: A Systematic Review.

40. Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset.

41. Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

42. Genetic links between ovarian ageing, cancer risk and de novo mutation rates.

43. Breast cancer risk assessment for prescription of menopausal hormone therapy in women with a family history of breast cancer: an epidemiological modelling study.

44. Rare germline genetic variation in PAX8 transcription factor binding sites and susceptibility to epithelial ovarian cancer.

45. Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma.

46. Cluster effect for SNP-SNP interaction pairs for predicting complex traits.

47. Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

48. Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people.

49. Mammographic Texture versus Conventional Cumulus Measure of Density in Breast Cancer Risk Prediction: A Literature Review.

50. Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England.

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