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Germline variation at 8q24 and prostate cancer risk in men of European ancestry
- Source :
- Nature Communications, Nat Commun. 2018 Nov 5;9(1):4616, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-06863-1, Recercat. Dipósit de la Recerca de Catalunya, instname, Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩, Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018), UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC), Matejcic, M, Saunders, E J, Dadaev, T, Brook, M N, Wang, K, Sheng, X, Olama, A A A, Schumacher, F R, Ingles, S A, Govindasami, K, Benlloch, S, Berndt, S I, Albanes, D, Koutros, S, Muir, K, Stevens, V L, Gapstur, S M, Tangen, C M, Batra, J, Clements, J, Gronberg, H, Pashayan, N, Schleutker, J, Wolk, A, West, C, Mucci, L, Kraft, P, Cancel-Tassin, G, Sorensen, K D, Maehle, L, Grindedal, E M, Strom, S S, Neal, D E, Hamdy, F C, Donovan, J L, Travis, R C, Hamilton, R J, Rosenstein, B, Lu, Y J, Giles, G G, Kibel, A S, Vega, A, Bensen, J T, Kogevinas, M, Penney, K L, Park, J Y, Stanford, J L, Cybulski, C, Nordestgaard, B G, Brenner, H & PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, 4616 . https://doi.org/10.1038/s41467-018-06863-1, Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Nature Communications, 9:4616. Nature Publishing Group
- Publication Year :
- 2018
- Publisher :
- Nature Research, 2018.
-
Abstract
- Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p<br />Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.
- Subjects :
- 0301 basic medicine
Oncology
Male
[SDV]Life Sciences [q-bio]
LOCI
General Physics and Astronomy
Genome-wide association study
PROGRESSION
[SDV.GEN] Life Sciences [q-bio]/Genetics
MYC
SUSCEPTIBILITY
UP-REGULATION
Prostate cancer
Risk Factors
Genotype
Urologi och njurmedicin
Medicine
lcsh:Science
Pròstata -- Càncer
education.field_of_study
RARE VARIANT
Multidisciplinary
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Manchester Cancer Research Centre
LONG NONCODING RNA
Chromosome Mapping
Men
3. Good health
[SDV] Life Sciences [q-bio]
Multidisciplinary Sciences
Science & Technology - Other Topics
Disease Susceptibility
Risk assessment
Chromosomes, Human, Pair 8
Genetic Markers
medicine.medical_specialty
Science
3122 Cancers
Population
[SDV.CAN]Life Sciences [q-bio]/Cancer
Risk Assessment
Article
General Biochemistry, Genetics and Molecular Biology
White People
03 medical and health sciences
[SDV.CAN] Life Sciences [q-bio]/Cancer
SDG 3 - Good Health and Well-being
Internal medicine
Genetics
Urology and Nephrology
Humans
Genetic Predisposition to Disease
GENOME-WIDE ASSOCIATION
education
Author Correction
METAANALYSIS
[SDV.GEN]Life Sciences [q-bio]/Genetics
Cancer och onkologi
Science & Technology
Càncer de pròstata
business.industry
ResearchInstitutes_Networks_Beacons/mcrc
Case-control study
Cancer
Prostatic Neoplasms
General Chemistry
3126 Surgery, anesthesiology, intensive care, radiology
medicine.disease
030104 developmental biology
Homes
Haplotypes
Cancer and Oncology
Case-Control Studies
lcsh:Q
Population Risk
business
Genètica
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nat Commun. 2018 Nov 5;9(1):4616, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-06863-1, Recercat. Dipósit de la Recerca de Catalunya, instname, Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩, Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018), UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC), Matejcic, M, Saunders, E J, Dadaev, T, Brook, M N, Wang, K, Sheng, X, Olama, A A A, Schumacher, F R, Ingles, S A, Govindasami, K, Benlloch, S, Berndt, S I, Albanes, D, Koutros, S, Muir, K, Stevens, V L, Gapstur, S M, Tangen, C M, Batra, J, Clements, J, Gronberg, H, Pashayan, N, Schleutker, J, Wolk, A, West, C, Mucci, L, Kraft, P, Cancel-Tassin, G, Sorensen, K D, Maehle, L, Grindedal, E M, Strom, S S, Neal, D E, Hamdy, F C, Donovan, J L, Travis, R C, Hamilton, R J, Rosenstein, B, Lu, Y J, Giles, G G, Kibel, A S, Vega, A, Bensen, J T, Kogevinas, M, Penney, K L, Park, J Y, Stanford, J L, Cybulski, C, Nordestgaard, B G, Brenner, H & PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, 4616 . https://doi.org/10.1038/s41467-018-06863-1, Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Nature Communications, 9:4616. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....79b75503a3e22f7b4ccc4372ef773086