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2. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

AUDEMARD-VERGER, Alexandra, AZZI, Emmanuel, BANNEVILLE, Béatrice, BAUDET, Antoine, BEAUDOUIN BAZIRE, Constance, BELIZNA, Cristina, Belot, Alexandre, BENHAMOU, Ygal, Berezné, Alice, BERNARD-GUERVILLY, Fanny, BERTHIER, Sabine, BEZANAHARY, Holy, BIALE, Lisa, BIGOT, Adrien, BLANCHARD-DELAUNAY, Claire, CALAS, Anne, CAMPAGNE, Julien, CATHEBRAS, Pascal, CAZALETS, Claire, CHAIGNE, Benjamin, CHANDESRIS, Olivia, CHATELAIS, Jérémy, CHATELUS, Emmanuel, COHEN, Fleur, Combe, Bernard, COMPARON, Céline, COQUERELLE, Pascal, DAMIAN, Louise, DAUGAS, Eric, DE MENTHON, Mathilde, DE MOREUIL, Claire, DELATTRE, Estelle, DELLAL, Azeddine, Deneux-Tharaux, Catherine, DENIS, Amélie, DEPROUW, Camille, DERNIS, Emmanuelle, DEROUX, Alban, DESOUCHES, Sandra, Dieudé, Philippe, DIREZ, Guillaume, Dougados, Maxime, DRIESSEN, Marine, DU THANH, Aurélie, DUNOGEANT, Laetitia, DURANT, Cécile, DUREL, Cécile-Audrey, DURIEU, Isabelle, EBOUE, Florence, Elefant, Elisabeth, FAIN, Olivier, FAUTREL, Bruno, FLIPO, René-Marc, FRAZIER, Aline, FROISSART, Antoine, GEORGIN-LAVIALLE, Sophie, GERVAIS, Elisabeth, GODEAU, Bertrand, Goffinet, François, GOMPEL, Anne, GOSSEC, Laure, GOUPILLE, Philippe, GRANGE, Claire, GUILLAUD-DANIS, Constance, HACHULLA, Eric, HOEFSLOOT, Sabine, HUMMEL, Aurélie, JEGO, Patrick, JOBARD, Stéphanie, JOSSELIN-MAHR, Laurence, LAMBERT, Marc, LANGLOIS, Vincent, LARIVIERE, Delphine, LARROCHE, Claire, LATOURTE, Augustin, LAVIGNE, Christian, LE GALLOU, Thomas, LEROUX, Gaëlle, LETAROUILLY, Jean Guillaume, LIOTÉ, Frédéric, Loeuillet, Laurence, London, Jonathan, Loustau, Valentine, LOZAC'H, Pierre, MAHEU, Emmanuel, MAILLARD, Hélène, MAROTTE, Hubert, MASSEAU, Agathe, MEKINIAN, Arsène, Melboucy Belkhir, Sara, Miceli-Richard, Corinne, MICHAUD, Martin, MICHEL, Marc, MORANNE, Olivier, MORATI-HAFSAOUI, Chafika, MOULIS, Guillaume, MOUTHON, Luc, NICOLAS, Barbara, Nizard, Jacky, ORA, Jérémy, OUTH, Rodérau, PASQUIER, Elisabeth, PENNAFORTE, Jean-Loup, PERLAT, Antoinette, PETIT-BAUER, Hélène, PILLEBOUT, Evangeline, PIOT, Jean-Maxime, PORTIER, Agnès, Pourrat, Olivier, PUECHAL, Xavier, PUGNET, Gregory, REDONDIN, Manon, REGENT, Alexis, RORIZ, Mélanie, SAILLER, Laurent, SAVEY, Léa, SCHERLINGER, Marc, SCHLEINITZ, Nicolas, Sellam, Jérémie, Sentilhes, Loïc, SERVAIS, Aude, SMETS, Perrine, SORDET, Christelle, SOUBRIER, Martin, STANKOVIC-STOJANOVIC, Katia, URBANSKI, Geoffrey, VEIT, Véronique, WEBER, Emmanuelle, YELNIK, Cécile, de Frémont, Grégoire Martin, Costedoat-Chalumeau, Nathalie, Lazaro, Estibaliz, Belkhir, Rakiba, Guettrot-Imbert, Gaëlle, Morel, Nathalie, Nocturne, Gaétane, Molto, Anna, Goulenok, Tiphaine, Diot, Elisabeth, Perard, Laurent, Ferreira-Maldent, Nicole, Le Besnerais, Maelle, Limal, Nicolas, Martis, Nihal, Abisror, Noémie, Debouverie, Odile, Richez, Christophe, Sobanski, Vincent, Maurier, François, Sauvetre, Gaëtan, Levesque, Hervé, Timsit, Marie-Agnès, Tieulié, Nathalie, Orquevaux, Pauline, Bienvenu, Boris, Mahevas, Matthieu, Papo, Thomas, Lartigau-Roussin, Céline, Chauvet, Elodie, Berthoux, Emilie, Sarrot-Reynauld, Françoise, Raffray, Loïc, Couderc, Marion, Silva, Nicolas Martin, Jourde-Chiche, Noémie, Belhomme, Nicolas, Thomas, Thierry, Poindron, Vincent, Queyrel-Moranne, Viviane, Delforge, Juliette, Le Ray, Camille, Pannier, Emmanuelle, Mariette, Xavier, Le Guern, Véronique, and Seror, Raphaèle

Published
2023
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3. Characterisation of a high-risk profile for maternal thrombotic and severe haemorrhagic complications in pregnant women with antiphospholipid syndrome in France (GR2): a multicentre, prospective, observational study

Author

Azzi, Emmanuel, Banneville, Béatrice, Baudet, Antoine, Beaudouin-Bazire, Constance, Belizna, Cristina, Belkhir, Rakiba, Berezne, Alice, Berthoux, Emilie, Berthier, Sabine, Biale, Lisa, Bienvenu, Boris, Blanchard-Delaunay, Claire, Cathebras, Pascal, Cazalets, Claire, Chaigne, Benjamin, Chandesris, Olivia, Chatelais, Jérémy, Chatelus, Emmanuel, Coquerelle, Pascal, Couderc, Marion, Delforge, Juliette, Denis, Amélie, Desouches, Sandra, Dieudé, Philippe, Direz, Guillaume, Driessen, Marine, Du Thanh, Aurélie, Dunogeant, Laetitia, Durant, Cécile, Durieu, Isabelle, Fabre, Marc, Fain, Olivier, Flipo, René-Marc, Frazier, Aline, Froissart, Antoine, Georgin-Lavialle, Sophie, Gervais, Elisabeth, Gompel, Anne, Gossec, Laure, Goupille, Phillipe, Grange, Claire, Guillaud-Danis, Constance, Hummel, Aurélie, Jallouli, Moez, Jego, Patrick, Jobard, Stéphane, Josselin-Mahr, Laurence, Jourde-Chiche, Noémie, Korganow, Anne-Sophie, Lambert, Marc, Lariviere, Delphine, Larroche, Claire, Lartigau-Roussin, Céline, Latourte, Augustin, Le Gallou, Thomas, Leroux, Gaëlle, Levesque, Hervé, Lioté, Frédéric, London, Jonathan, Loustau, Valentine, Maheu, Emmanuel, Mahevas, Matthieu, Maillard, Hélène, Mariette, Xavier, Marotte, Hubert, Martin-Silva, Nicolas, Martis, Nihal, Masseau, Agathe, Mekinian, Arsène, Melboucy-Belkhir, Sara, Michaud, Martin, Michel, Marc, Morati-Hafsaoui, Chafika, Nizard, Jacky, Ora, Jérémy, Pennaforte, Jean-Loup, Perlat, Antoinette, Petit Bauer, Hélène, Pillebout, Evangeline, Piot, Jean-Maxime, Portier, Agnès, Pugnet, Gregory, Redondin, Manon, Regent, Alexis, Richez, Christophe, Roriz, Mélanie, Sailler, Laurent, Sauvêtre, Gaëtan, Savey, Léa, Sobanski, Vincent, Sordet, Christelle, Soubrier, Martin, Stankovic Stojanovic, Katia, Thomas, Thierry, Timsit, Marie-Agnès, Tsatsaris, Vassilis, Murarasu, Anne, Guettrot-Imbert, Gaëlle, Le Guern, Véronique, Yelnik, Cécile, Queyrel, Viviane, Schleinitz, Nicolas, Ferreira-Maldent, Nicole, Diot, Elisabeth, Urbanski, Geoffrey, Pannier, Emmanuelle, Lazaro, Estibaliz, Souchaud-Debouverie, Odile, Orquevaux, Pauline, Belhomme, Nicolas, Morel, Nathalie, Chauvet, Elodie, Maurier, François, Le Besnerais, Maëlle, Abisror, Noemie, Goulenok, Tiphaine, Sarrot-Reynauld, Françoise, Deroux, Alban, Pasquier, Elisabeth, de Moreuil, Claire, Bezanahary, Holy, Pérard, Laurent, Limal, Nicolas, Langlois, Vincent, Calas, Anne, Godeau, Bertrand, Lavigne, Christian, Hachulla, Eric, Cohen, Fleur, Benhamou, Ygal, Raffray, Loïc, de Menthon, Mathilde, Tieulié, Nathalie, Poindron, Vincent, Mouthon, Luc, Larosa, Maddalena, Eléfant, Elisabeth, Sentilhes, Loic, Molto, Anna, Deneux-Tharaux, Catherine, and Costedoat-Chalumeau, Nathalie

Published
2022
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5. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

de Frémont, Grégoire Martin, primary, Costedoat-Chalumeau, Nathalie, additional, Lazaro, Estibaliz, additional, Belkhir, Rakiba, additional, Guettrot-Imbert, Gaëlle, additional, Morel, Nathalie, additional, Nocturne, Gaétane, additional, Molto, Anna, additional, Goulenok, Tiphaine, additional, Diot, Elisabeth, additional, Perard, Laurent, additional, Ferreira-Maldent, Nicole, additional, Le Besnerais, Maelle, additional, Limal, Nicolas, additional, Martis, Nihal, additional, Abisror, Noémie, additional, Debouverie, Odile, additional, Richez, Christophe, additional, Sobanski, Vincent, additional, Maurier, François, additional, Sauvetre, Gaëtan, additional, Levesque, Hervé, additional, Timsit, Marie-Agnès, additional, Tieulié, Nathalie, additional, Orquevaux, Pauline, additional, Bienvenu, Boris, additional, Mahevas, Matthieu, additional, Papo, Thomas, additional, Lartigau-Roussin, Céline, additional, Chauvet, Elodie, additional, Berthoux, Emilie, additional, Sarrot-Reynauld, Françoise, additional, Raffray, Loïc, additional, Couderc, Marion, additional, Silva, Nicolas Martin, additional, Jourde-Chiche, Noémie, additional, Belhomme, Nicolas, additional, Thomas, Thierry, additional, Poindron, Vincent, additional, Queyrel-Moranne, Viviane, additional, Delforge, Juliette, additional, Le Ray, Camille, additional, Pannier, Emmanuelle, additional, Mariette, Xavier, additional, Le Guern, Véronique, additional, Seror, Raphaèle, additional, AUDEMARD-VERGER, Alexandra, additional, AZZI, Emmanuel, additional, BANNEVILLE, Béatrice, additional, BAUDET, Antoine, additional, BEAUDOUIN BAZIRE, Constance, additional, BELIZNA, Cristina, additional, Belot, Alexandre, additional, BENHAMOU, Ygal, additional, Berezné, Alice, additional, BERNARD-GUERVILLY, Fanny, additional, BERTHIER, Sabine, additional, BEZANAHARY, Holy, additional, BIALE, Lisa, additional, BIGOT, Adrien, additional, BLANCHARD-DELAUNAY, Claire, additional, CALAS, Anne, additional, CAMPAGNE, Julien, additional, CATHEBRAS, Pascal, additional, CAZALETS, Claire, additional, CHAIGNE, Benjamin, additional, CHANDESRIS, Olivia, additional, CHATELAIS, Jérémy, additional, CHATELUS, Emmanuel, additional, COHEN, Fleur, additional, Combe, Bernard, additional, COMPARON, Céline, additional, COQUERELLE, Pascal, additional, DAMIAN, Louise, additional, DAUGAS, Eric, additional, DE MENTHON, Mathilde, additional, DE MOREUIL, Claire, additional, DELATTRE, Estelle, additional, DELLAL, Azeddine, additional, Deneux-Tharaux, Catherine, additional, DENIS, Amélie, additional, DEPROUW, Camille, additional, DERNIS, Emmanuelle, additional, DEROUX, Alban, additional, DESOUCHES, Sandra, additional, Dieudé, Philippe, additional, DIREZ, Guillaume, additional, Dougados, Maxime, additional, DRIESSEN, Marine, additional, DU THANH, Aurélie, additional, DUNOGEANT, Laetitia, additional, DURANT, Cécile, additional, DUREL, Cécile-Audrey, additional, DURIEU, Isabelle, additional, EBOUE, Florence, additional, Elefant, Elisabeth, additional, FAIN, Olivier, additional, FAUTREL, Bruno, additional, FLIPO, René-Marc, additional, FRAZIER, Aline, additional, FROISSART, Antoine, additional, GEORGIN-LAVIALLE, Sophie, additional, GERVAIS, Elisabeth, additional, GODEAU, Bertrand, additional, Goffinet, François, additional, GOMPEL, Anne, additional, GOSSEC, Laure, additional, GOUPILLE, Philippe, additional, GRANGE, Claire, additional, GUILLAUD-DANIS, Constance, additional, HACHULLA, Eric, additional, HOEFSLOOT, Sabine, additional, HUMMEL, Aurélie, additional, JEGO, Patrick, additional, JOBARD, Stéphanie, additional, JOSSELIN-MAHR, Laurence, additional, LAMBERT, Marc, additional, LANGLOIS, Vincent, additional, LARIVIERE, Delphine, additional, LARROCHE, Claire, additional, LATOURTE, Augustin, additional, LAVIGNE, Christian, additional, LE GALLOU, Thomas, additional, LEROUX, Gaëlle, additional, LETAROUILLY, Jean Guillaume, additional, LIOTÉ, Frédéric, additional, Loeuillet, Laurence, additional, London, Jonathan, additional, Loustau, Valentine, additional, LOZAC'H, Pierre, additional, MAHEU, Emmanuel, additional, MAILLARD, Hélène, additional, MAROTTE, Hubert, additional, MASSEAU, Agathe, additional, MEKINIAN, Arsène, additional, Melboucy Belkhir, Sara, additional, Miceli-Richard, Corinne, additional, MICHAUD, Martin, additional, MICHEL, Marc, additional, MORANNE, Olivier, additional, MORATI-HAFSAOUI, Chafika, additional, MOULIS, Guillaume, additional, MOUTHON, Luc, additional, NICOLAS, Barbara, additional, Nizard, Jacky, additional, ORA, Jérémy, additional, OUTH, Rodérau, additional, PASQUIER, Elisabeth, additional, PENNAFORTE, Jean-Loup, additional, PERLAT, Antoinette, additional, PETIT-BAUER, Hélène, additional, PILLEBOUT, Evangeline, additional, PIOT, Jean-Maxime, additional, PORTIER, Agnès, additional, Pourrat, Olivier, additional, PUECHAL, Xavier, additional, PUGNET, Gregory, additional, REDONDIN, Manon, additional, REGENT, Alexis, additional, RORIZ, Mélanie, additional, SAILLER, Laurent, additional, SAVEY, Léa, additional, SCHERLINGER, Marc, additional, SCHLEINITZ, Nicolas, additional, Sellam, Jérémie, additional, Sentilhes, Loïc, additional, SERVAIS, Aude, additional, SMETS, Perrine, additional, SORDET, Christelle, additional, SOUBRIER, Martin, additional, STANKOVIC-STOJANOVIC, Katia, additional, URBANSKI, Geoffrey, additional, VEIT, Véronique, additional, WEBER, Emmanuelle, additional, and YELNIK, Cécile, additional

Published
2023
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6. Characterisation of a high-risk profile for maternal thrombotic and severe haemorrhagic complications in pregnant women with antiphospholipid syndrome in France (GR2): a multicentre, prospective, observational study

Author

Murarasu, Anne, primary, Guettrot-Imbert, Gaëlle, additional, Le Guern, Véronique, additional, Yelnik, Cécile, additional, Queyrel, Viviane, additional, Schleinitz, Nicolas, additional, Ferreira-Maldent, Nicole, additional, Diot, Elisabeth, additional, Urbanski, Geoffrey, additional, Pannier, Emmanuelle, additional, Lazaro, Estibaliz, additional, Souchaud-Debouverie, Odile, additional, Orquevaux, Pauline, additional, Belhomme, Nicolas, additional, Morel, Nathalie, additional, Chauvet, Elodie, additional, Maurier, François, additional, Le Besnerais, Maëlle, additional, Abisror, Noemie, additional, Goulenok, Tiphaine, additional, Sarrot-Reynauld, Françoise, additional, Deroux, Alban, additional, Pasquier, Elisabeth, additional, de Moreuil, Claire, additional, Bezanahary, Holy, additional, Pérard, Laurent, additional, Limal, Nicolas, additional, Langlois, Vincent, additional, Calas, Anne, additional, Godeau, Bertrand, additional, Lavigne, Christian, additional, Hachulla, Eric, additional, Cohen, Fleur, additional, Benhamou, Ygal, additional, Raffray, Loïc, additional, de Menthon, Mathilde, additional, Tieulié, Nathalie, additional, Poindron, Vincent, additional, Mouthon, Luc, additional, Larosa, Maddalena, additional, Eléfant, Elisabeth, additional, Sentilhes, Loic, additional, Molto, Anna, additional, Deneux-Tharaux, Catherine, additional, Costedoat-Chalumeau, Nathalie, additional, Azzi, Emmanuel, additional, Banneville, Béatrice, additional, Baudet, Antoine, additional, Beaudouin-Bazire, Constance, additional, Belizna, Cristina, additional, Belkhir, Rakiba, additional, Berezne, Alice, additional, Berthoux, Emilie, additional, Berthier, Sabine, additional, Biale, Lisa, additional, Bienvenu, Boris, additional, Blanchard-Delaunay, Claire, additional, Cathebras, Pascal, additional, Cazalets, Claire, additional, Chaigne, Benjamin, additional, Chandesris, Olivia, additional, Chatelais, Jérémy, additional, Chatelus, Emmanuel, additional, Coquerelle, Pascal, additional, Couderc, Marion, additional, Delforge, Juliette, additional, Denis, Amélie, additional, Desouches, Sandra, additional, Dieudé, Philippe, additional, Direz, Guillaume, additional, Driessen, Marine, additional, Du Thanh, Aurélie, additional, Dunogeant, Laetitia, additional, Durant, Cécile, additional, Durieu, Isabelle, additional, Fabre, Marc, additional, Fain, Olivier, additional, Flipo, René-Marc, additional, Frazier, Aline, additional, Froissart, Antoine, additional, Georgin-Lavialle, Sophie, additional, Gervais, Elisabeth, additional, Gompel, Anne, additional, Gossec, Laure, additional, Goupille, Phillipe, additional, Grange, Claire, additional, Guillaud-Danis, Constance, additional, Hummel, Aurélie, additional, Jallouli, Moez, additional, Jego, Patrick, additional, Jobard, Stéphane, additional, Josselin-Mahr, Laurence, additional, Jourde-Chiche, Noémie, additional, Korganow, Anne-Sophie, additional, Lambert, Marc, additional, Lariviere, Delphine, additional, Larroche, Claire, additional, Lartigau-Roussin, Céline, additional, Latourte, Augustin, additional, Le Gallou, Thomas, additional, Leroux, Gaëlle, additional, Levesque, Hervé, additional, Lioté, Frédéric, additional, London, Jonathan, additional, Loustau, Valentine, additional, Maheu, Emmanuel, additional, Mahevas, Matthieu, additional, Maillard, Hélène, additional, Mariette, Xavier, additional, Marotte, Hubert, additional, Martin-Silva, Nicolas, additional, Martis, Nihal, additional, Masseau, Agathe, additional, Mekinian, Arsène, additional, Melboucy-Belkhir, Sara, additional, Michaud, Martin, additional, Michel, Marc, additional, Morati-Hafsaoui, Chafika, additional, Nizard, Jacky, additional, Ora, Jérémy, additional, Pennaforte, Jean-Loup, additional, Perlat, Antoinette, additional, Petit Bauer, Hélène, additional, Pillebout, Evangeline, additional, Piot, Jean-Maxime, additional, Portier, Agnès, additional, Pugnet, Gregory, additional, Redondin, Manon, additional, Regent, Alexis, additional, Richez, Christophe, additional, Roriz, Mélanie, additional, Sailler, Laurent, additional, Sauvêtre, Gaëtan, additional, Savey, Léa, additional, Sobanski, Vincent, additional, Sordet, Christelle, additional, Soubrier, Martin, additional, Stankovic Stojanovic, Katia, additional, Thomas, Thierry, additional, Timsit, Marie-Agnès, additional, and Tsatsaris, Vassilis, additional

Published
2022
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7. Ultrasound Classification of Finger Pulp Blood Flow in Patients With Systemic Sclerosis: A Pilot Study

Author

Lescoat, Alain, primary, Robin, François, additional, Belhomme, Nicolas, additional, Ballerie, Alice, additional, de Saint Riquier, Marine, additional, Sebillot, Martine, additional, Albert, Jean‐David, additional, Le Gallou, Thomas, additional, Perdriger, Aleth, additional, Jégo, Patrick, additional, Coiffier, Guillaume, additional, and Cazalets, Claire, additional

Published
2022
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8. Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue

Author

Zimmermann, François, primary, Robin, François, additional, Caillault, Leila, additional, Cazalets, Claire, additional, Llamas-Gutierrez, Francisco, additional, Garlantézec, Ronan, additional, Jousse-Joulin, Sandrine, additional, Diot, Elisabeth, additional, Mensi, Sami Eric, additional, Belhomme, Nicolas, additional, Jégo, Patrick, additional, Coiffier, Guillaume, additional, and Lescoat, Alain, additional

Published
2022
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10. Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue.

Author

Zimmermann, François, Robin, François, Caillault, Leila, Cazalets, Claire, Llamas-Gutierrez, Francisco, Garlantézec, Ronan, Jousse-Joulin, Sandrine, Diot, Elisabeth, Mensi, Sami Eric, Belhomme, Nicolas, Jégo, Patrick, Coiffier, Guillaume, and Lescoat, Alain

Subjects
SJOGREN'S syndrome diagnosis, PULMONARY arterial hypertension, SYSTEMIC scleroderma, QUALITY of life, XEROSTOMIA, SJOGREN'S syndrome, PULMONARY fibrosis, SALIVARY glands, SYMPTOMS
Abstract

SSc is an auto-immune disease characterized by life-threatening manifestations such as lung fibrosis or pulmonary arterial hypertension. Symptoms with a detrimental impact on quality of life are also reported and sicca syndrome (xerostomia, xeropthalmia) is present in up to 80% of patients with SSc. Sicca syndrome can occur in the absence of overlap with Sjögren's disease and recent studies highlight that fibrosis of minor and major salivary glands, directly linked to the pathogenesis of SSc, could be a major contributor of xerostomia in SSc. This narrative review provides an overview of the clinical presentation, diagnostic strategies, management and future perspectives on sicca syndrome in patients with SSc. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Ultrasound Classification of Finger Pulp Blood Flow in Patients With Systemic Sclerosis: A Pilot Study.

Author

Lescoat, Alain, Robin, François, Belhomme, Nicolas, Ballerie, Alice, de Saint Riquier, Marine, Sebillot, Martine, Albert, Jean‐David, Le Gallou, Thomas, Perdriger, Aleth, Jégo, Patrick, Coiffier, Guillaume, and Cazalets, Claire

Subjects
BLOOD flow, SYSTEMIC scleroderma, DOPPLER ultrasonography, RADIAL artery, ULTRASONIC imaging
Abstract

Objective: To define a semiquantitative classification of finger pulp blood flow (FPBF) and to evaluate whether this classification could be used to assess FPBF in healthy controls and in systemic sclerosis (SSc) patients. Methods: Thirty controls and 86 SSc patients were consecutively included. A classification of FPBF including 5 grades (from grade 0 [no signal] to 4 [signal detected on the entire finger pulp, including the subepidermal vascular network]) was evaluated. This classification was explored in basal conditions and after hand baths in hot and cold water in controls. Its relevance was also assessed at room temperature in SSc patients. Results: In controls, power Doppler ultrasonography (PDUS) of FPBF was improved after hot challenge (P = 0.024), whereas cold challenge decreased FPBF (P = 0.001). FPBF correlated with the vasodilation status assessed by the resistivity index of radial arteries (Spearman's correlation coefficient = –0.50, P = 0.0049). Grade 0 was more frequent in SSc patients than in controls (22.1% versus 3.3%; P < 0.05). In SSc patients, grade 0 was associated with severity markers of the digital vasculopathy such as digital ulcers (DUs) (current or past) (P < 0.05) or ulnar artery occlusion (P < 0.05). On the other hand, DUs were less frequent in patients with grade 4 (P < 0.05). A pathologic threshold of <2 (grade 0 or 1) was significantly associated with DUs (odds ratio 6.67 [95% confidence interval 2.31–19.21], P < 0.0001). Conclusion: PDUS allowed a semiquantitative evaluation of FBPF in SSc patients and controls. Further studies are warranted to validate these results in independent SSc populations and to compare PDUS to existing tools assessing digital blood flow. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Efficacy of sildenafil on ischaemic digital ulcer healing in systemic sclerosis: the placebo-controlled SEDUCE study

Author

Hachulla, Eric, Hatron, Pierre-Yves, Carpentier, Patrick, Agard, Christian, Chatelus, Emmanuel, Jego, Patrick, Mouthon, Luc, Queyrel, Viviane, Fauchais, Anne-Laure, Michon-Pasturel, Ulrique, Jaussaud, Roland, Mathian, Alexis, Granel, Brigitte, Diot, Elisabeth, Farge-Bancel, Dominique, Mekinian, Arsène, Avouac, Jérôme, Desmurs-Clavel, Hélène, Clerson, Pierre, Quemeneur, Thomas, Balquet, Marie-Hélène, Wojtasik, Géraldine, Lambert, Marc, Launay, David, Maillard, Hélène, Morell-Dubois, Sandrine, Le Gouellec, Noémie, Marie, Isabelle, Tieulie, Nathalie, Deligny, Christophe, Bienvenu, Boris, Berezne, Alice, Lazareth, Isabelle, Khelifa, Sondess Hadj, Tiev, Kiet, Cabane, Jean, Hervier, Baptiste, Amoura, Zahir, Allanore, Yannick, Arnault, Jean-Philippe, Berthier, Sabine, Cazalets, Claire, Ly, Kim, Sparsa, Agnès, Sibilia, Jean, and Ninet, Jacques

Published
2016
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15. Hand ultrasound for the diagnosis of scleroderma a scoring strategy including US items and items from the EULAR/ACR classification

Author

de Saint Riquier, Marine, Ballerie, Alice, Robin, François, Belhomme, Nicolas, Cazalets, Claire, Droitcourt, Catherine, Perdriger, Aleth, Yelnik, Cécile Marie, Hachulla, Eric, Sobanski, Vincent, Jego, Patrick, Coiffier, Guillaume, Lescoat, Alain, CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
[SDV] Life Sciences [q-bio], Scleroderma, Localized, Ulnar Artery, Scleroderma, Systemic, [SDV]Life Sciences [q-bio], Humans, Microscopic Angioscopy, Ultrasonography
Abstract

International audience; OBJECTIVES:To evaluate the diagnostic value of hand ultrasound (US) in systemic sclerosis (SSc) and to explore its relevance within a combined diagnostic approach.METHODS:224 patients with suspected SSc were consecutively included. They all had US evaluation assessing the presence of fibrotic tenosynovitis (fibrotic TS) and ulnar artery occlusion (UAO). The final diagnosis of SSc was based on the clinical evaluation of a board of experts independently of any pre-established classification criteria.RESULTS:166 patients were finally diagnosed as SSc according to the experts as reference standard. 62 SSc and 8 non-SSc patients had UAO (uni or bilateral) (p=0.001). 23 SSc patients and 1 non-SSc patient had US fibrotic TS (p=0.007). A US SSc-pattern (presence of UAO and/or fibrotic TS) was reported in 73 SSc patients and 9 non-SSc patients (p

Published
2020

17. The neglected association of crystalline silica exposure and systemic sclerosis

Author

Lescoat, Alain, primary, Ballerie, Alice, additional, Lecureur, Valérie, additional, Belhomme, Nicolas, additional, Cazalets, Claire, additional, Jouneau, Stéphane, additional, Paris, Christophe, additional, Menéndez-Navarro, Alfredo, additional, Rosental, Paul-André, additional, Jégo, Patrick, additional, and Cavalin, Catherine, additional

Published
2020
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18. Association of silica exposure with chest HRCT and clinical characteristics in systemic sclerosis

Author

Ballerie, Alice, primary, Cavalin, Catherine, additional, Lederlin, Mathieu, additional, Nicolas, Amélie, additional, Garlantézec, Ronan, additional, Jouneau, Stéphane, additional, Lecureur, Valérie, additional, Cazalets, Claire, additional, Belhomme, Nicolas, additional, Paris, Christophe, additional, Rosental, Paul-André, additional, Jégo, Patrick, additional, and Lescoat, Alain, additional

Published
2020
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19. Silica Exposure and Scleroderma: More Bridges and Collaboration between Disciplines Are Needed

Author

Lescoat, Alain, primary, Cavalin, Catherine, additional, Ballerie, Alice, additional, Lecureur, Valérie, additional, Sesé, Lucile, additional, Cazalets, Claire, additional, Lederlin, Mathieu, additional, Coiffier, Guillaume, additional, Belhomme, Nicolas, additional, Paris, Christophe, additional, Garlantézec, Ronan, additional, Jouneau, Stéphane, additional, and Jégo, Patrick, additional

Published
2020
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21. HISTORY OF SILICA DUST EXPOSURES AND ASSOCIATION WITH CHEST HRCT AND CLINICAL CHARACTERISTICS IN SYSTEMIC SCLEROSIS

Author

Ballerie, Alice, Cavalin, Catherine, Lederlin, Mathieu, Nicolas, Amélie, Garlantezec, Ronan, Jouneau, Stephane, Cazalets, Claire, Belhomme, Nicolas, Rosental, Paul-Andre, Jego, Patrick, Lescoat, Alain, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre d'études européennes et de politique comparée (CEE), Centre National de la Recherche Scientifique (CNRS)-Sciences Po (Sciences Po), CHU Pontchaillou [Rennes], Département de Radiologie [CHU de Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut national d'études démographiques (INED), Jonchère, Laurent, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut de Recherche Interdisciplinaire en Sciences Sociales (IRISSO), Institut National de la Recherche Agronomique (INRA)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and Université de Rennes (UR)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

22. Ulnar Artery Occlusion and Severity Markers of Vasculopathy in Systemic Sclerosis: A Multicenter Cross‐Sectional Study

Author

Lescoat, Alain, primary, Yelnik, Cécile Marie, additional, Coiffier, Guillaume, additional, Wargny, Matthieu, additional, Lamotte, Christophe, additional, Cazalets, Claire, additional, Belhomme, Nicolas, additional, Ballerie, Alice, additional, Hatron, Pierre‐Yves, additional, Launay, David, additional, Perdriger, Aleth, additional, Sobanski, Vincent, additional, Hachulla, Eric, additional, and Jégo, Patrick, additional

Published
2019
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26. Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature

Author

Sanges, Sébastien, primary, Rivière, Sébastien, additional, Mekinian, Arsène, additional, Martin, Thierry, additional, Le Quellec, Alain, additional, Chatelus, Emmanuel, additional, Lescoat, Alain, additional, Jego, Patrick, additional, Cazalets, Claire, additional, Quéméneur, Thomas, additional, Le Gouellec, Noémie, additional, Senet, Patricia, additional, Francès, Camille, additional, Deroux, Alban, additional, Imbert, Bernard, additional, Fain, Olivier, additional, Boukari, Latifatou, additional, Sené, Thomas, additional, Deligny, Christophe, additional, Mathian, Alexis, additional, Agard, Christian, additional, Pugnet, Grégory, additional, Speca, Silvia, additional, Dubucquoi, Sylvain, additional, Hatron, Pierre-Yves, additional, Hachulla, Éric, additional, and Launay, David, additional

Published
2017
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28. Efferocytosis capacities of blood monocyte‐derived macrophages in systemic sclerosis.

Author

Ballerie, Alice, Lescoat, Alain, Augagneur, Yu, Lelong, Marie, Morzadec, Claudie, Cazalets, Claire, Jouneau, Stéphane, Fardel, Olivier, Vernhet, Laurent, Jégo, Patrick, and Lecureur, Valérie

Subjects
MONOCYTES, MACROPHAGES, SYSTEMIC scleroderma, SCAVENGER receptors (Biochemistry), INTEGRINS
Abstract

A defect in the apoptotic cell clearance (efferocytosis) by phagocytic cells may participate in autoimmunity and chronic inflammation. The mechanisms leading to the emergence of autoimmunity in systemic sclerosis (SSc) are still to be determined. In this study, the efferocytosis capacities of blood monocyte‐derived macrophages (MDM) from patients with SSc were evaluated. Blood monocytes obtained from patients with SSc and healthy donors (HD) were differentiated in vitro into macrophages. The capacities of MDM to engulf CFSE+ apoptotic Jurkat human T lymphocytes were compared between SSc MDM and HD using flow cytometry. The expression of classical engulfing receptors in SSc MDM and HD MDM was also evaluated and their involvement in the modulation of efferocytosis was confirmed using a siRNA approach. The mean phagocytic index (PI) reflecting efferocytosis capacities of SSc MDM (PI = 19.3 ± 3.0; n = 21) was significantly decreased in comparison with the PI of HD MDM (PI = 35.9 ± 3.0; n = 31; P < 0.001). In comparison with HD, SSc MDM exhibited a downregulated expression of scavenger receptor (SR)‐B1, SR‐A1 and integrin β5 (ITGβ5). In HD MDM, the extinction of these receptors was followed by a reduction of efferocytosis only for the repression of ITGβ5, suggesting a possible selective role of this integrin in the impaired efferocytosis observed in SSc. As efferocytosis may be at the crossroads of inflammation, autoimmunity and fibrosis, in showing impaired efferocytosis capacities of blood MDM in SSc, our study offers new pathogenesis considerations for the involvement of macrophages in the autoimmune processes driving this disorder. Efferocytosis capacities are strongly decreased in monocyte‐derived macrophages from systemic sclerosis (SSc) patients. A downexpression of integrin β5 in proinflammatory and in SSc macrophages may explain a deficient efferocytosis. Impaired efferocytosis of macrophages may play a key role in autoimmune processes in SSc. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Hand ultrasound for the diagnosis of scleroderma: a scoring strategy including US items and items from the EULAR/ACR classification.

Author

de Saint Riquier M, Ballerie A, Robin F, Belhomme N, Cazalets C, Droitcourt C, Perdriger A, Yelnik CM, Hachulla E, Sobanski V, Jégo P, Coiffier G, and Lescoat A

Subjects
Humans, Microscopic Angioscopy, Ulnar Artery, Ultrasonography, Scleroderma, Localized, Scleroderma, Systemic
Abstract

Objectives: To evaluate the diagnostic value of hand ultrasound (US) in systemic sclerosis (SSc) and to explore its relevance within a combined diagnostic approach., Methods: 224 patients with suspected SSc were consecutively included. They all had US evaluation assessing the presence of fibrotic tenosynovitis (fibrotic TS) and ulnar artery occlusion (UAO). The final diagnosis of SSc was based on the clinical evaluation of a board of experts independently of any pre-established classification criteria., Results: 166 patients were finally diagnosed as SSc according to the experts as reference standard. 62 SSc and 8 non-SSc patients had UAO (uni or bilateral) (p=0.001). 23 SSc patients and 1 non-SSc patient had US fibrotic TS (p=0.007). A US SSc-pattern (presence of UAO and/or fibrotic TS) was reported in 73 SSc patients and 9 non-SSc patients (p<0.001). UAO had an area under ROC curve (AUC) for the diagnosis of SSc of 0.618 (95%CI 0.539- 0.697); with Se=0.373 (0.304-0.449) and Sp=0.862 (0.751-0.928). Fibrotic TS had an AUC of 0.561 (0.480-0.643); with Se=0.139 (0.094-0.199) and Sp=0.983 (0.909-0.997). The US-SSc pattern had a AUC of 0.641 (0.563- 0.695), with Se=0.440 (0.367-0.516) and Sp=0.845 (0.731-0.916). A scoring system including these US parameters and items from ACR/EULAR classification criteria had an AUC of 0.979 (0.962-0.996)) and allows the substitution of capillaroscopy by US parameters with similar performances., Conclusions: The use of hand US parameters may help to refine the diagnostic strategy of SSc and their inclusion in a combined diagnostic approach could be discussed.

Published
2020

33. [Monoclonal gammopathies of undetermined significance and their progression over time. Retrospective study of 190 patients].

Author

Decaux O, Cuggia M, Ruelland A, Cazalets C, Cador B, Jego P, and Grosbois B

Subjects
Adult, Aged, Aged, 80 and over, Disease Progression, Female, Follow-Up Studies, Hematologic Neoplasms epidemiology, Humans, Immunoglobulin A blood, Immunoglobulin G blood, Immunoglobulin M blood, Male, Middle Aged, Paraproteinemias diagnosis, Paraproteinemias immunology, Patient Selection, Retrospective Studies, Time Factors, Paraproteinemias physiopathology
Abstract

Introduction: Monoclonal gammopathies of undetermined significance (MGUS) occur in up to 1% of persons aged 50 years or older. The risk of its progression to multiple myeloma or related disorders is also approximately 1% per year., Objectives: Our study had two aims: to describe the risk of malignant progression of patients examined in our center for MGUS, and to identify predictors of this malignant progression., Methods: We retrospectively reviewed the medical records of patients with MGUS seen in our center from 1980 through 1995. Information about progression came either from the medical file or from responses to questionnaires sent to patients' general practitioners., Results: The study included 190 patients. Median follow-up was 84 months (range: 12-240 months). MGUS remained stable for 128 patients (67.37%), whose median follow-up was 96 months. Malignant transformations occurred in 41 patients (21.58%). The median interval from diagnosis of MGUS to diagnosis of a lymphoplasma cell proliferative disorder was 49 months. The cumulative probability of progression was 13.05% at 5 years and 25.14% at 10 years. The initial concentration of serum monoclonal protein was a significant predictor of progression (threshold value: 15 g/L)., Discussion: The cumulative probability of progression in our study is higher than that observed elsewhere. Our results may well be biased by the short follow-up period and selective referrals., Conclusion: The initial concentration of serum monoclonal protein is a significant predictor of malignant progression of MGUS.

Published
2006
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34. [Human iron deficiency].

Author

Grosbois B, Decaux O, Cador B, Cazalets C, and Jego P

Subjects
Anemia, Iron-Deficiency diagnosis, Anemia, Iron-Deficiency epidemiology, Humans, Anemia, Iron-Deficiency etiology, Anemia, Iron-Deficiency therapy
Abstract

Iron deficiency is the most widespread nutritional disorder in the world, affecting an estimated 1.2 billion people. Its prevalence is particularly high in developing countries (Africa, Asia, South America), but iron deficiency remains a public health problem in industrialised countries. Three successive stages of iron deficiency can be distinguished: iron store depletion, iron-deficient erythropoesis and iron-deficiency anemia. Investigations of iron deficiency should take into account the clinical background. In groups at risk (infants and children, women of childbearing age, pregnant women), management is limited to nutritional inquiries, gynecological examination, and oral iron supplementation. In men and post-menopausal women, iron deficiency is assumed to result from occult gastrointestinal bleeding, and this may necessitate upper and lower gastrointestinal endoscopy. Benign lesions are more frequently found in the upper digestive tract than in the lower digestive tract. When these investigations are negative and iron supplementation is unsuccessful, video-capsule endoscopy is recommended. Oral iron treatment is based on ferrous salts (200 mg/d). The duration of treatment depends on the severity of iron deficiency, ranging from three months for iron store depletion and iron-deficient erythropeisis to six months for iron-deficiency anemia.

Published
2005

35. [Clostridium difficile infection in a Department of Internal Medicine. A consecutive series of 45 patients].

Author

Bligny D, Cador B, Jolivet-Gougeon A, Le Strat A, Cazalets C, Laurat E, Jego P, Bouget J, and Grosbois B

Subjects
Aged, Aged, 80 and over, Community-Acquired Infections, Female, Humans, Length of Stay, Male, Middle Aged, Retrospective Studies, Anti-Bacterial Agents adverse effects, Clostridioides difficile, Cross Infection diagnosis, Cross Infection etiology, Diarrhea diagnosis, Diarrhea etiology, Enterocolitis, Pseudomembranous diagnosis, Enterocolitis, Pseudomembranous etiology
Abstract

Objectives and Methods: A retrospective study of 45 patients with Clostridium difficile infection over a 4-year period in a department of Internal Medicine., Results: Mean age was 79 years; sex-ratio (F/M)=1.5; 38% of the patients had neurological or severe psychiatric disorders; 20% had a neoplastic disease. Ninety-three percent of cases had received one or more antibiotics before onset of diarrhea, prescribed mainly for a pulmonary infection. Amoxicillin clavulanic acid and cephalosporins were the most frequently used treatments, respectively in 48% and 40% of cases. For 25 patients (56%) Clostridium difficile-associated diarrhea was considered as a nosocomial infection, and as community-acquired diarrhea in 20 cases (44%). Treatment included isolation of the patient as soon as bacteriological diagnosis was known and specific therapy was instituted by metronidazole or vancomycin for a mean of 18 days. The addition of Saccharomyces boulardii was used in of cases. The clinical course was rapidly favorable for 80% of patients. Five patients died with complications of severe colitis in 2 cases. Mean hospital stay was 49 days (annual mean of the department=10 days)., Conclusion: Clostridium difficile diarrhea concerns above all elderly patients with one or more underlying pathologies. Amoxicillin clavulanic acid and third-generation cephalosporins are the most frequently prescribed antibiotics in these cases and have the highest correlation with this infectious complication. This medical problem requires greater knowledge as it causes significant morbidity and increases the risk of prolonged hospital stays.

Published
2002

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