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The article discusses the effectiveness of a human milk donation promotion program in a virtual group of Mexican women. It highlights the challenges of exclusive breastfeeding in Mexico and the global lack of breastfeeding culture. The article explores the use of social media platforms, such as Facebook, for promoting breastfeeding and milk donation. It also emphasizes the importance of mutual support groups and the role of digital networks in promoting maternal and child health. The study focuses on the effectiveness of the program and its impact on the participants' attitudes and behaviors. The findings suggest that the virtual group improves the promotion of human milk donation by creating unofficial support networks and facilitating information sharing. The article concludes by highlighting the significance of qualitative exploration and the potential of sociodigital networks in improving maternal and child health in Mexico and Latin America. [Extracted from the article]

Introduction: Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been reported that telomere length is associated with a higher susceptibility of developing cancer., Objective: The objective of this study was to understand the relationship between CYP19 TTTA repetition polymorphism and telomere length and its effects on serum estradiol, estrone and follicle-stimulating hormone (FSH)., Materials and Methods: A total of 180 postmenopausal healthy and 70 BC-diagnosed women were included. Telomere length was determined through real-time quantitative polymerase chain reaction, and aromatase polymorphism was analyzed through DNA; both samples were obtained from circulating leukocytes. Serum estrone, estradiol and FSH were determined by enzyme-linked immunosorbent assay., Results: Patients with a BC diagnosis showed >10 repetitions more frequently, compared with that of healthy women (50% vs 23%, χ 2 = 11.44, p = 0.0007). A significant difference in telomere length between healthy and BC women was observed (5,042.7 vs 2,256.7 pb, Z = 4.88, p < 0.001). CYP19 TTTA repeat polymorphism was associated with serum levels of estradiol and estrone in both groups, being higher in those with >10 repeats. Moreover, telomere length showed an inverse relationship with the number of repeats of the aromatase polymorphism in healthy women ( R 2 = 0.04, r = -0.24); in contrast, BC patients did not display this relationship. In addition, telomere length presented an inverse relationship with serum levels of estradiol and estrone in BC patients ( p = 0.02)., Conclusion: Telomere length is shorter in BC patients than in healthy patients. The CYP19 TTTA repeat polymorphism is associated with serum levels of estradiol and estrone in both healthy women and BC patients, being higher in those with polymorphism carriers >10 repeats. Telomere length has an inverse correlation with the number of repeats of the aromatase polymorphism in healthy women but not in BC women. Estradiol and estrone levels in BC women have an inverse relationship with telomere length., Competing Interests: The authors report no conflicts of interest in this work.