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5. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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6. Real‐life effectiveness of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients previously treated with sofosbuvir/velpatasvir or glecaprevir/pibrentasvir.

Author

Ruiz‐Cobo, Juan Carlos, Llaneras, Jordi, Forns, Xavier, Gallego Moya, Adolfo, Conde Amiel, Isabel, Arencibia, Ana, Diago, Moises, García‐Samaniego, Javier, Castellote, Jose, Llerena, Susana, Rodríguez‐Seguel, Elisa, Mateos, Beatriz, Rodríguez, Manuel, Rosales Zabal, Jose Miguel, Fernández, Inmaculada, Calleja, Jose Luis, Morillas, Rosa María, Montoliu, Silvia, Andrade, Raul J., and Badia Aranda, Ester

Subjects
HEPATITIS C, CHRONIC hepatitis C, HEPATITIS C virus, SOFOSBUVIR, END of treatment
Abstract

Summary: Background: Sofosbuvir, velpatasvir and voxilaprevir (SOF/VEL/VOX) is the recommended rescue therapy for patients with chronic hepatitis C infection who fail direct‐acting antivirals (DAAs). Data are limited on the effectiveness of this treatment after the current first‐line therapies. Our aim was to analyse the effectiveness and safety of SOF/VEL/VOX among patients failing sofosbuvir/velpatasvir (SOF/VEL) or glecaprevir/pibrentasvir (GLE/PIB). Methods: Retrospective multicentre study (26 Spanish hospitals), including chronic hepatitis C patients unsuccessfully treated with SOF/VEL or GLE/PIB, and retreated with SOF/VEL/VOX ± ribavirin for 12 weeks between December 2017 and December 2022. Results: In total, 142 patients included: 100 (70.4%) had failed SOF/VEL and 42 (29.6%) GLE/PIB. Patients were mainly men (84.5%), White (93.9%), with hepatitis C virus genotype (GT) 3 (49.6%) and 47.2% had liver cirrhosis. Sustained virological response (SVR) was evaluated in 132 patients who completed SOF/VEL/VOX and were followed 12 weeks after end of treatment; 117 (88.6%) achieved SVR. There were no significant differences in SVR rates according to initial DAA treatment (SOF/VEL 87.9% vs. GLE/PIB 90.2%, p = 0.8), cirrhosis (no cirrhosis 90% vs. cirrhosis 87.1%, p = 0.6) or GT3 infection (non‐GT3 91.9% vs. GT3 85.5%, p = 0.3). However, when considering the concurrent presence of SOF/VEL treatment, cirrhosis and GT3 infection, SVR rates dropped to 82.8%. Ribavirin was added in 8 (6%) patients, all achieved SVR. Conclusion: SOF/VEL/VOX is an effective rescue therapy for failures to SOF/VEL or GLE/PIB, with an SVR of 88.6%. Factors previously linked to lower SVR rates, such as GT3 infection, cirrhosis and first‐line therapy with SOF/VEL were not associated with lower SVRs. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial

Author

Solà, Elsa, Solé, Cristina, Simón-Talero, Macarena, Martín-Llahí, Marta, Castellote, José, Garcia-Martínez, Rita, Moreira, Rebeca, Torrens, Maria, Márquez, Francisca, Fabrellas, Núria, de Prada, Gloria, Huelin, Patrícia, Lopez Benaiges, Eva, Ventura, Meritxell, Manríquez, Marcela, Nazar, André, Ariza, Xavier, Suñé, Pilar, Graupera, Isabel, Pose, Elisa, Colmenero, Jordi, Pavesi, Marco, Guevara, Mónica, Navasa, Miquel, Xiol, Xavier, Córdoba, Joan, Vargas, Victor, and Ginès, Pere

Published
2018
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15. Impact of direct-acting antiviral therapy on survival in patients with liver cirrhosis and ascites. Data from the hepa-C registry

Author

Romero, Álvaro Hidalgo, primary, Lens, Sabela, additional, Muñoz, Beatriz Mateos, additional, Ferrer, Maria Teresa, additional, Conde, Marta Hernandez, additional, Rodríguez, Manuel, additional, Castellote, Jose, additional, Cabezas, Joaquín, additional, Llaneras, Jordi, additional, Alonso, Sonia, additional, Moreno Planas, Jose María, additional, Carrión, José Antonio, additional, Torras, Xavier, additional, Badia-Aranda, Esther, additional, Molina, Esther, additional, Serrano, Mercedes, additional, Turnes, Juan, additional, Alvarez, Paula Fernandez, additional, Guerra, Manuel Hernández, additional, Hernandez, Olga, additional, Garcia, Pablo Bellot, additional, and Vázquez, Inmaculada Fernández, additional

Published
2023
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16. Long-term use of somatostatin analogs for chronic gastrointestinal bleeding in hereditary hemorrhagic telangiectasia

Author

Torres-Iglesias, Raquel, primary, Mora-Luján, José María, additional, Iriarte, Adriana, additional, Cerdà, Pau, additional, Alba, Esther, additional, Sánchez-Corral, Miguel Ángel, additional, Berrozpe, Ana, additional, Cruellas, Francesc, additional, Gamundí, Enric, additional, Ribas, Jesús, additional, Castellote, Jose, additional, and Riera-Mestre, Antoni, additional

Published
2023
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17. Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding

Author

Rudler, Marika, Hernández-Gea, Virginia, Procopet, Bogdan Dumitru, Giráldez, Alvaro, Amitrano, Lucio, Villanueva, Càndid, Ibañez, Luis, Silva-Junior, Gilberto, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise Lotte, Noronha Ferreira, Carlos, Canete, Nouria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Larrue, Hélène, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Schwarzer, Remy, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Gonzalez, Javier Martínez, Catalina, Maria Vega, Albillos, Agustín, Alvarado, Edilmar, Guardascione, Maria Anna, Mallet, Maxime, Tripon, Simona, Casanovas, Georgina, Bosch, Jaume, Garcia-Pagan, Juan-Carlos, Thabut, Dominique, Rudler, Marika, Hernández-Gea, Virginia, Procopet, Bogdan Dumitru, Giráldez, Alvaro, Amitrano, Lucio, Villanueva, Càndid, Ibañez, Luis, Silva-Junior, Gilberto, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise Lotte, Noronha Ferreira, Carlos, Canete, Nouria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Larrue, Hélène, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Schwarzer, Remy, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Gonzalez, Javier Martínez, Catalina, Maria Vega, Albillos, Agustín, Alvarado, Edilmar, Guardascione, Maria Anna, Mallet, Maxime, Tripon, Simona, Casanovas, Georgina, Bosch, Jaume, Garcia-Pagan, Juan-Carlos, and Thabut, Dominique

Abstract

Background: A pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS) reduces mortality in high-risk patients with cirrhosis (Child-Pugh C/B+active bleeding) with acute variceal bleeding (AVB). Real-life studies point out that <15% of patients eligible for pTIPS ultimately undergo transjugular intrahepatic portosystemic shunt (TIPS) due to concerns about hepatic encephalopathy (HE). The outcome of patients undergoing pTIPS with HE is unknown. We aimed to (1) assess the prevalence of HE in patients with AVB; (2) evaluate the outcome of patients presenting HE at admission after pTIPS; and (3) determine if HE at admission is a risk factor for death and post-TIPS HE. Patients and methods: This is an observational study including 2138 patients from 34 centres between October 2011 and May 2015. Placement of pTIPS was based on individual centre policy. Patients were followed up to 1 year, death or liver transplantation. Results: 671 of 2138 patients were considered at high risk, 66 received pTIPS and 605 endoscopic+drug treatment. At admission, HE was significantly more frequent in high-risk than in low-risk patients (39.2% vs 10.6%, p<0.001). In high-risk patients with HE at admission, pTIPS was associated with a lower 1-year mortality than endoscopic+drug (HR 0.374, 95% CI 0.166 to 0.845, p=0.0181). The incidence of HE was not different between patients treated with pTIPS and endoscopic+drug (38.2% vs 38.7%, p=0.9721), even in patients with HE at admission (56.4% vs 58.7%, p=0.4594). Age >56, shock, Model for End-Stage Liver Disease score >15, endoscopic+drug treatment and HE at admission were independent factors of death in high-risk patients. Conclusion: pTIPS is associated with better survival than endoscopic treatment in high-risk patients with cirrhosis with variceal bleeding displaying HE at admission.

Published
2023

18. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, Genesca, Joan, Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, and Genesca, Joan

Abstract

Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

19. Perioperative Complications and Long-Term Follow-Up of Liver Transplantation in Hemorrhagic Hereditary Telangiectasia: Report of Three Cases and Systematic Review

Author

Riera-Mestre, Antoni, primary, Cerdà, Pau, additional, Guzmán, Yoelimar Carolina, additional, Iriarte, Adriana, additional, Torroella, Alba, additional, Mora-Luján, José María, additional, Castellote, Jose, additional, Hessheimer, Amelia, additional, Fondevila, Constantino, additional, and Lladó, Laura, additional

Published
2022
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20. Hepatic encephalopathy is not a contraindication to pre-emptive TIPS in high-risk patients with cirrhosis with variceal bleeding

Author

Rudler, Marika, primary, Hernández-Gea, Virginia, additional, Procopet, Bogdan Dumitru, additional, Giráldez, Alvaro, additional, Amitrano, Lucio, additional, Villanueva, Càndid, additional, Ibañez, Luis, additional, Silva-Junior, Gilberto, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Bañares, Rafael, additional, Krag, Aleksander, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose Maria, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise Lotte, additional, Noronha Ferreira, Carlos, additional, Canete, Nouria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernandez-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell’era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Larrue, Hélène, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Schwarzer, Remy, additional, Jansen, Christian, additional, Robic, Marie-Angèle, additional, Conejo, Irene, additional, Martínez Gonzalez, Javier, additional, Catalina, Maria Vega, additional, Albillos, Agustín, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Mallet, Maxime, additional, Tripon, Simona, additional, Casanovas, Georgina, additional, Bosch, Jaume, additional, Garcia-Pagan, Juan-Carlos, additional, and Thabut, Dominique, additional

Published
2022
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21. High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4

Author

Mariño, Zoe, Pascasio‐Acevedo, Juan M., Gallego, Adolfo, Diago, Moisés, Baliellas, Carme, Morillas, Rosa, Prieto, Martín, Moreno, José M., Sánchez‐Antolín, Gloria, Vergara, Mercedes, Forné, Montserrat, Fernández, Inmaculada, Castro, María A., Pascual, Sonia, Gómez, Alexandra, Castells, Lluis, Montero, José L., Crespo, Javier, Calleja, José L., García‐Samaniego, Javier, Carrión, Jose A., Arencibia, Ana C., Blasco, Alejandro, López‐Núñez, Carmen, Sánchez‐Ruano, Juan J., Gea‐Rodríguez, Francisco, Giráldez, Álvaro, Cabezas, Joaquín, Hontangas, Vanessa, Torras, Xavier, Castellote, Jose, Romero‐Gómez, Manuel, Turnes, Juan, de Artaza, Tomás, Narváez, Isidoro, Cuervas‐Mons, Valentín, and Forns, Xavier

Published
2017
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23. Efficacy and safety of daclatasvir‐based antiviral therapy in hepatitis C virus recurrence after liver transplantation. Role of cirrhosis and genotype 3. A multicenter cohort study

Author

Salcedo, Magdalena, Prieto, Martín, Castells, Lluís, Pascasio, Juan Manuel, Montero Alvarez, Jose Luis, Fernández, Inmaculada, Sánchez‐Antolín, Gloria, González‐Diéguez, Luisa, García‐Gonzalez, Miguel, Otero, Alejandra, Lorente, Sara, Espinosa, Maria Dolores, Testillano, Milagros, González, Antonio, Castellote, Jose, Casafont, Fernando, Londoño, Maria‐Carlota, Pons, Jose Antonio, Molina Pérez, Esther, Cuervas‐Mons, Valentín, Pascual, Sonia, Herrero, Jose Ignacio, Narváez, Isidoro, Vinaixa, Carmen, Llaneras, Jordi, Sousa, Jose Manuel, and Bañares, Rafael

Published
2017
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24. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramon, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J M, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L, Ferreira, Carlos N, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria A, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martinez, Javier, Robic, Marie A, Jansen, Christian, Calleja, Jose L, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagan, Juan C, and Genescà, Joan

Subjects
alcohol, upper gastrointestinal bleeding, cirrhosis, alcohol-related hepatitis, 610 Medicine & health, abstinence
Abstract

BACKGROUND & AIMS Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. METHODS Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. RESULTS The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. CONCLUSIONS Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2021

25. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Martínez, Javier, primary, Hernández-Gea, Virginia, additional, Rodríguez-de-Santiago, Enrique, additional, Téllez, Luis, additional, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luis, additional, Silva-Junior, Gilberto, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Bañares, Rafael, additional, Krag, Aleksander, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose María, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Noronha-Ferreira, Carlos, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Schwarzer, Remy, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G., additional, Romero-Gomez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Robic, Marie Angèle, additional, Conejo, Irene, additional, Catalina, Maria Vega, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Perez-Campuzano, Valeria, additional, Guardascione, Maria Anna, additional, Fischer, Petra, additional, Bosch, Jaime, additional, García-Pagán, Juan Carlos, additional, and Albillos, Agustín, additional

Published
2021
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26. A notable proportion of liver transplant candidates with alcohol-related cirrhosis can be delisted because of clinical improvement

Author

Pose, Elisa, primary, Torrents, Abiguei, additional, Reverter, Enric, additional, Perez-Campuzano, Valeria, additional, Campos-Varela, Isabel, additional, Avitabile, Emma, additional, Gratacós-Ginès, Jordi, additional, Castellote, Jose, additional, Castells, Lluis, additional, Colmenero, Jordi, additional, Tort, Jaume, additional, Ginès, Pere, additional, and Crespo, Gonzalo, additional

Published
2021
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29. THU-171 - Impact of direct-acting antiviral therapy on survival in patients with liver cirrhosis and ascites. Data from the hepa-C registry

Author

Romero, Álvaro Hidalgo, Lens, Sabela, Muñoz, Beatriz Mateos, Ferrer, Maria Teresa, Conde, Marta Hernandez, Rodríguez, Manuel, Castellote, Jose, Cabezas, Joaquín, Llaneras, Jordi, Alonso, Sonia, Moreno Planas, Jose María, Carrión, José Antonio, Torras, Xavier, Badia-Aranda, Esther, Molina, Esther, Serrano, Mercedes, Turnes, Juan, Alvarez, Paula Fernandez, Guerra, Manuel Hernández, Hernandez, Olga, Garcia, Pablo Bellot, and Vázquez, Inmaculada Fernández

Published
2023
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30. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria Vega, Erasmus, Hans Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Robic, Marie Angèle, Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria Vega, Erasmus, Hans Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, and Robic, Marie Angèle

Abstract

Background & Aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of transjugular intrahepatic portosystemic shunt (TIPS) in the management in patients with ACLF has not been described to date. Methods: A multicenter, international, observational study was conducted in 2,138 patients from 34 centers between 2011 and 2015. ACLF was defined and graded according to the EASL-CLIF consortium definition. Placement of pre-emptive TIPS (pTIPS) was based on individual center policy. Patients were followed-up for 1 year, until death or liver transplantation. Cox regression and competing risk models (Gray's test) were used to identify independent predictors of rebleeding or mortality. Results: At admission, 380/2,138 (17.8%) patients had ACLF according to EASL-CLIF criteria (grade 1: 38.7%; grade 2: 39.2%; grade 3: 22.1%). The 42-day rebleeding (19% vs. 10%; p <0.001) and mortality (47% vs. 10%; p <0.001) rates were higher in patients with ACLF and increased with ACLF grades. Of note, the presence of ACLF was independently associated with rebleeding and mortality. pTIPS placement improved survival in patients with ACLF at 42 days and 1 year. This effect was also observed in propensity score matching analysis of 66 patients with ACLF, of whom 44 received pTIPs and 22 did not. Conclusions: This large multicenter international real-life study identified ACLF at admission as an independent predictor of rebleeding and mortality in patients with AVB. Moreover, pTIPS was associated with improved survival in patients with ACLF and AVB. Lay summary: Acute variceal bleeding is a deadly complication of liver cirrhosis that results from severe portal hypertension. This study demonstrates that the presence of acute-on-chronic liver failure (ACLF) is the strongest predictor of mortality in patients with acute

Published
2020

31. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, primary, Gu, Wenyi, additional, Ibáñez-Samaniego, Luis, additional, Hernández-Gea, Virginia, additional, Pitarch, Carla, additional, Garcia, Elisabet, additional, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Cristophe, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose Maria, additional, Castellote, Jose, additional, Rodrigues, Susanag, additional, Gluud, Liselotte, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G., additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Weiss, Emmanuel, additional, Catalina, Maria-Vega, additional, Erasmus, Hans-Peter, additional, Uschner, Frank Erhard, additional, Schulz, Martin, additional, Brol, Maximilian J., additional, Praktiknjo, Michael, additional, Chang, Johannes, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Robic, Marie Angèle, additional, Conejo, Irene, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Pavesi, Marco, additional, Garcia-Pagán, Juan Carlos, additional, Jansen, Christian, additional, and Bañares, Rafael, additional

Published
2020
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43. OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., Stanley, Adrian J., Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez, Alvaro, Sanchez, Candido V., Thabut, Dominique, Ibanez-Samaniego, Luis, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, Jose M., Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L., Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dellera, Alessandra, Senzolo, Marco, Abraldes, Juan, Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Jansen, Christian, Robic, Marie A., Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar A., Guardascione, Maria A., Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Garcia-Pagan, Juan C., and Krag, Aleksander

Published
2019

47. 551 OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., primary, Stanley, Adrian J., additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giráldez, Alvaro, additional, Sanchez, Cándido V., additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luís, additional, Martinez, Javier, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose M., additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Ferreira, Carlos Noronha, additional, Barceló, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose L., additional, Grønbæk, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dellera, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Jansen, Christian, additional, Robic, Marie A., additional, Conejo, Irene, additional, Catalina, María-Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar A., additional, Guardascione, Maria A., additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Garcia-Pagán, Juan C., additional, and Krag, Aleksander, additional

Published
2019
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48. PS-022-Optimal timing of endoscopy is associated with lower 42-day mortality in variceal bleeding

Author

Laursen, Stig Borbjerg, primary, Stanley, Adrian, additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luis, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jm, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L, additional, Ferreira, Carlos Noronha, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell’Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Robic, Marie Angele, additional, Conejo, Irene, additional, Catalina, Maria-Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Garcia-Pagán, Juan Carlos, additional, and Krag, Aleksander, additional

Published
2019
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49. Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study

Author

Hernández‐Gea, Virginia, primary, Procopet, Bogdan, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Ibañez‐Samaniego, Luis, additional, Silva‐Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose Maria, additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Noronha Ferreira, Carlos, additional, Barcelo, Rafael, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Gronbaek, Henning, additional, Hernández‐Guerra, Manuel, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan G., additional, Romero‐Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Robic, Marie Angèle, additional, Conejo, Irene, additional, Catalina, Maria‐Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, and Garcia‐Pagán, Juan Carlos, additional

Published
2018
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