Back to Search
Start Over
Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode
- Source :
- Villagrasa, A, Hernandez-Gea, V, Ventura-Cots, M, Bataller, R, Giraldez-Gallego, A, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibanez, L, Silva-Junior, G, Albillos, A, Bureau, C, Jonel, T, Llop, E, Laleman, W, Maria Palazon, J, Castellote Alonso, J, Rodrigues, S G, Gluud, L L, Ferreira, C N, Canete, N, Rodriguez, M, Ferlitsch, A, Luis Mundi, J, Gronbaek, H, Hernandez-Guerra, M, Sassatelli, R, Dell'Era, A, Senzolo, M, Abraldes, J, Romero Gomez, M, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Tantau, M, Maria, G, Alvarado, E, Rudler, M, Banares, R, Martinez, J, Robic, M-A, Jansen, C, Calleja Panero, J L, Nevens, F, Bosch, J, Garcia Pagan, J C & Genesca, J 2021, ' Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode ', Journal of Hepatology, vol. 75, no. Suppl. 2, PO-48, pp. S307-S309 ., Villagrasa, A, Hernandez-Gea, V, Ventura-Cots, M, Bataller, R, Giraldez, A, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibanez Samaniego, L, Silva-Junior, G, Albillos, A, Bureau, C, Trebicka, J, Llop, E, Laleman, W, Palazon Azorin, J M, Castellote, J, Rodrigues, S, Gluud, L L, Noronha Ferreira, C, Canete, N, Rodriguez, MA, Ferlitsch, A, Luis Mundi, J, Gronbaek, H, Hernandez-Guerra, M, Sassatelli, R, Dell'era, A, Senzolo, M, Abraldes, J G, Romero-Gomez, M, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Tantau, M, Anna Guardascione, M, Alvarado-Tapias, E, Rudler, M, Canizares, R B, Martinez, J, Robic, M-A, Jansen, C, Calleja Panero, J L, Nevens, F, Bosch, J, Carlos Garcia-Pagan, J & Genesca, J 2021, ' ALCOHOL-RELATED LIVER DISEASE PHENOTYPE IMPACTS SURVIVAL AFTER AN ACUTE VARICEAL BLEEDING EPISODE ', Hepatology, vol. 74, no. Suppl. 1, pp. 202A-203A ., University of Southern Denmark, Journal of Hepatology, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, Villagrasa, A, Hernández-Gea, V, Bataller, R, Giráldez, Á, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibañez-Samaniego, L, Albillos, A, Bureau, C, Trebicka, J, Llop, E, Laleman, W, Palazon, J M, Castellote, J, Rodrigues, S, Gluud, L L, Ferreira, C N, Cañete, N, Rodríguez, M, Ferlitsch, A, Mundi, J L, Gronbaek, H, Hernández-Guerra, M, Sassatelli, R, Dell'Era, A, Senzolo, M, Abraldes, J G, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Silva-Junior, G, Romero-Gómez, M, Tantau, M, Guardascione, M A, Alvarado, E, Rudler, M, Bañares, R, Martinez, J, Robic, M A, Jansen, C, Calleja, J L, Nevens, F, Bosch, J, Ventura-Cots, M, García-Pagan, J C, Genescà, J & for the International Variceal Bleeding Observational Study Group; Baveno Cooperation 2023, ' Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode ', Liver International, vol. 43, no. 7, pp. 1548-1557 . https://doi.org/10.1111/liv.15606, Hepatology
- Publication Year :
- 2021
-
Abstract
- BACKGROUND & AIMS Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. METHODS Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. RESULTS The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. CONCLUSIONS Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.
Details
- Language :
- English
- ISSN :
- 16000641 and 02709139
- Database :
- OpenAIRE
- Journal :
- Villagrasa, A, Hernandez-Gea, V, Ventura-Cots, M, Bataller, R, Giraldez-Gallego, A, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibanez, L, Silva-Junior, G, Albillos, A, Bureau, C, Jonel, T, Llop, E, Laleman, W, Maria Palazon, J, Castellote Alonso, J, Rodrigues, S G, Gluud, L L, Ferreira, C N, Canete, N, Rodriguez, M, Ferlitsch, A, Luis Mundi, J, Gronbaek, H, Hernandez-Guerra, M, Sassatelli, R, Dell'Era, A, Senzolo, M, Abraldes, J, Romero Gomez, M, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Tantau, M, Maria, G, Alvarado, E, Rudler, M, Banares, R, Martinez, J, Robic, M-A, Jansen, C, Calleja Panero, J L, Nevens, F, Bosch, J, Garcia Pagan, J C & Genesca, J 2021, ' Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode ', Journal of Hepatology, vol. 75, no. Suppl. 2, PO-48, pp. S307-S309 ., Villagrasa, A, Hernandez-Gea, V, Ventura-Cots, M, Bataller, R, Giraldez, A, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibanez Samaniego, L, Silva-Junior, G, Albillos, A, Bureau, C, Trebicka, J, Llop, E, Laleman, W, Palazon Azorin, J M, Castellote, J, Rodrigues, S, Gluud, L L, Noronha Ferreira, C, Canete, N, Rodriguez, MA, Ferlitsch, A, Luis Mundi, J, Gronbaek, H, Hernandez-Guerra, M, Sassatelli, R, Dell'era, A, Senzolo, M, Abraldes, J G, Romero-Gomez, M, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Tantau, M, Anna Guardascione, M, Alvarado-Tapias, E, Rudler, M, Canizares, R B, Martinez, J, Robic, M-A, Jansen, C, Calleja Panero, J L, Nevens, F, Bosch, J, Carlos Garcia-Pagan, J & Genesca, J 2021, ' ALCOHOL-RELATED LIVER DISEASE PHENOTYPE IMPACTS SURVIVAL AFTER AN ACUTE VARICEAL BLEEDING EPISODE ', Hepatology, vol. 74, no. Suppl. 1, pp. 202A-203A ., University of Southern Denmark, Journal of Hepatology, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, Villagrasa, A, Hernández-Gea, V, Bataller, R, Giráldez, Á, Procopet, B, Amitrano, L, Villanueva, C, Thabut, D, Ibañez-Samaniego, L, Albillos, A, Bureau, C, Trebicka, J, Llop, E, Laleman, W, Palazon, J M, Castellote, J, Rodrigues, S, Gluud, L L, Ferreira, C N, Cañete, N, Rodríguez, M, Ferlitsch, A, Mundi, J L, Gronbaek, H, Hernández-Guerra, M, Sassatelli, R, Dell'Era, A, Senzolo, M, Abraldes, J G, Zipprich, A, Casas, M, Masnou, H, Primignani, M, Krag, A, Silva-Junior, G, Romero-Gómez, M, Tantau, M, Guardascione, M A, Alvarado, E, Rudler, M, Bañares, R, Martinez, J, Robic, M A, Jansen, C, Calleja, J L, Nevens, F, Bosch, J, Ventura-Cots, M, García-Pagan, J C, Genescà, J & for the International Variceal Bleeding Observational Study Group; Baveno Cooperation 2023, ' Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode ', Liver International, vol. 43, no. 7, pp. 1548-1557 . https://doi.org/10.1111/liv.15606, Hepatology
- Accession number :
- edsair.doi.dedup.....a1c152e677b031c281a6a877bf5dd541