1. Can 18F-FDG PET/CT alone or combined with radiology be used to reliably grade cartilage bone neoplasms for surgical decision making?
- Author
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Natasha Singh, Rajeev Reddy, Ashik Bary, Rajat Gupta, Manit K. Gundavda, and Manish Agarwal
- Subjects
medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Resection ,Histology grade ,Positron Emission Tomography Computed Tomography ,Medicine ,Cutoff ,Radiology, Nuclear Medicine and imaging ,Fdg pet ct ,Radiology ,Chondrosarcoma ,business ,Dedifferentiated chondrosarcoma ,Cartilage bone ,Grading (tumors) - Abstract
OBJECTIVE Treatment of chondrosarcomas is grade based; intralesional curettage for grade 1 and resection for grade 2 or more. Currently used methods to determine grades before surgery are not highly accurate and create a dilemma for the surgeon. We have used a PET-CT combined with imaging to answer the following study questions: (1) Does SUVmax value from an 18F-FDG PET/CT correlate with the grade of chondrosarcoma? (2) Can a cutoff SUVmax value be used to differentiate between various grades of chondroid neoplasms with sufficient sensitivity and specificity? (3) Does SUVmax guide the clinician and add value to radiology in offering histologic grade-dependent management? METHODS SUVmax values of patients with suspected chondrosarcoma were retrospectively correlated with the final histology grade for the operated patients. Radiologic parameters and radiology aggressiveness scores (RAS) were reevaluated and tabulated. RESULTS Totally 104 patients with chondroid tumors underwent 18F-FDG PET/CT assessment. In total 73 had tissue diagnosis available as a pretreatment investigation. Spearman correlation indicated that there was a significant positive association between SUVmax and the final histology grading of chondroid tumors (correlation coefficient = 0.743; P
- Published
- 2021