13 results on '"Carlos A. Gotelli"'
Search Results
2. Hexachlorocyclohexane chemical remediation of a contaminated site in Argentina
- Author
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A. Lo Balbo, G. M. Caballero, Mariano J. Gotelli, and Carlos A. Gotelli
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Environmental remediation ,General Medicine ,Human decontamination ,Persulfate ,Soil contamination ,Sodium persulfate ,Phytoremediation ,chemistry.chemical_compound ,chemistry ,Environmental chemistry ,Environmental Chemistry ,Environmental science ,Sulfate ,Citric acid ,Waste Management and Disposal ,Water Science and Technology - Abstract
This work describes the complete decontamination of three parcels of a dump site located in Lomas de Zamora county, Buenos Aires province (Argentina) heavily polluted with hexachorocyclohexane (HCH), where phytoremediation, successful in the surrounding areas, was ineffective. HCH contained in contaminated soil (10 g/kg average) was oxidized with sodium persulfate activated with citric acid chelated Fe(II). This chemical remediation process required treatment in situ in each parcel of approximately 10900 tons total of soil that were mechanically removed and initially mixed with 1750 tons of sodium persulfate. The mixture was then transferred to the excavation site, and 105 tons of ferrous sulfate and 35 tons of citric acid were finally added. The process, started in January 2011 and completed in February 2016, was very effective since chemical remediation average efficiency in the three parcels was higher than 99.99%. To the best of our knowledge this work is the first demonstration that persulfate oxidation activated with citric acid chelated Fe(II) can be successfully applied for field remediation of a relatively large area.
- Published
- 2021
3. DOSE-RESPONSE RELATIONS IN THE NEPHROTOXIC ACTION OF MERCURY BASED ON 'SPOT URINE' SAMPLES
- Author
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Gary L. Diamond, Elsa Cernichiari, Thomas W. Clarkson, E. Astolfi, John B. Hursh, Christopher Cox, Carlos A. Gotelli, M. Barac-Nieto, and G. Forbes
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Pharmacology ,Creatinine ,Dose-Response Relationship, Drug ,Chemistry ,Body Weight ,Infant ,chemistry.chemical_element ,Mercury ,gamma-Glutamyltransferase ,Urine ,Phenylmercury Compounds ,Toxicology ,Mercury (element) ,Nephrotoxicity ,Spot urine ,chemistry.chemical_compound ,Environmental chemistry ,Humans ,Kidney Diseases - Published
- 2009
4. Bioavailability, absorption mechanism, and toxicity of microencapsulated iron (I) sulfate
- Author
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José Boccio, Ricardo Weill, Carlos A. Gotelli, Mariano J. Gotelli, Alexis Lysionek, Marcela Zubillaga, and Ricardo A. Caro
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Male ,Drug Compounding ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Population ,Inorganic chemistry ,Biological Availability ,Absorption (skin) ,Biochemistry ,Median lethal dose ,Ferrous ,Lethal Dose 50 ,Inorganic Chemistry ,Mice ,chemistry.chemical_compound ,Animals ,Ferrous Compounds ,Food science ,Sulfate ,education ,Analysis of Variance ,education.field_of_study ,Chemistry ,Biochemistry (medical) ,Food fortification ,General Medicine ,Bioavailability ,Intestinal Absorption ,Toxicity ,Female - Abstract
The iron compounds used for food fortification have to meet certain requisites related to their bioavailability, absorption mechanism, and toxicity, since they will be consumed by a massive population group. With these purposes, we evaluated a new product used for the iron fortification of milk and lacteous derivatives, called SFE-171, which is a ferrous sulfate, microencapsulated with phospholipids. The bioavailability studies were carried out using four groups of 30 female mice each. In two groups, we studied the absorption of ferrous ascorbate and ferrous sulfate, both in water as reference standards, which show absorptions of 13.1+/-4.9% and 13.2+/-4.3%, respectively. With the third group, we studied the absorption of ferrous sulfate in milk; its value, 7.9+/-3.2%, is significantly lower than that of the remaining groups, with a p0.01. The studies with SFE-171 in milk, were performed on the fourth group, with a result of 11.6+/-4.5%, demonstrating that its absorption does not differ significantly from that of the reference standards. The absorption mechanism was determined by means of in vivo self-displacement studies of the ferrous ion and the SFE-171, taking ferrous sulfate as the reference compound. For this study, 210 female mice were used, and no significant difference between the absorption mechanism of both products could be observed. Toxicity studies of the new product with regard to ferrous sulfate were carried out with two groups of 70 female mice each and two groups of 70 male mice each. The lethal dose 50% LD50 for SFE-171 and for ferrous sulfate was 1200 and 680 mg/kg for female mice and 1230 and 670 mg/kg for male mice, respectively, demonstrating that the toxicity of the first product is substantially lower than that of the reference standard. We conclude that the iron product under study has a high bioavailability, an absorption mechanism equal to that of nonhemic iron, and lower toxicity than ferrous sulfate.
- Published
- 1998
5. New procedure to fortify fluid milk with iron: Metabolic and biochemical study in rats
- Author
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JoséR. Boccio, Carlos A. Gotelli, Marcela Zubillaga, Ricardo A. Caro, Ricardo Weill, and Mariano J. Gotelli
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Biodistribution ,Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Phospholipid ,Pasteurization ,Metabolism ,law.invention ,Bioavailability ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Biochemistry ,Fluid milk ,law ,Hemoglobin ,Food science - Abstract
A comparative study with two groups of 25 rats each was undertaken in order to study fluid milk fortified with SFE-171 (stabilized FeSO 4 by micro encapsulation with phospholipids) or FeSO 4 , both labeled with 59 Fe. After the administration of either product, its total absorption, biodistribution and incorporation of iron into hemoglobin was determined for both cases. In the first case the total absorption was (28.3 ± 6.0)%, whereas in the second it was (24.1 ± 5.8)%, the difference between both values is statistically significant with a P 4 . The highest amount (approximately 80%) was found in blood, followed by the liver with approximately 11% and bones with a proportion somewhat higher than 4%, the activity in intestine was minimal in both cases. The 59 Fe in blood was found 18 days after the administration of either product at a 100% in the red blood cells, which implies that the iron administered in the milk fortified with SFE-171 or with FeSO 4 was incorporated into hemoglobin. These results indicate with a high degree of significance that the fortification of milk with SFE-171 is a procedure which assures the effective absorption of iron and a physiological behavior of this element.
- Published
- 1996
6. Bioavailability and Stability of Microencapsulated Ferrous Sulfate in Fluid Milk: Studies in Mice
- Author
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Ricardo A. Caro, Mariano J. Gotelli, Carlos A. Gotelli, Ricardo Weill, Marcela Zubillaga, and José Boccio
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Hot Temperature ,Time Factors ,food.ingredient ,Drug Compounding ,Population ,Biological Availability ,Medicine (miscellaneous) ,Ascorbic Acid ,Lecithin ,Absorption ,Ferrous ,Mice ,chemistry.chemical_compound ,food ,Drug Stability ,Fluid milk ,Oral administration ,medicine ,Animals ,Ferrous Compounds ,Food science ,Sulfate ,education ,education.field_of_study ,Nutrition and Dietetics ,Chemistry ,digestive, oral, and skin physiology ,food and beverages ,Iron deficiency ,medicine.disease ,Bioavailability ,Milk ,Biochemistry ,Phosphatidylcholines ,Female - Abstract
Iron deficiency is the most important nutritional problem all over the world. Fluid milk is an attractive vehicle for iron fortification, since it is a food with a high nutritional value, accessible to the whole population and easy to be given to children. Fortification of this food with iron has the disadvantage of the interaction of the iron with the constitutive elements of milk, diminishing its bioavailability and changing its sensorial properties, making it unacceptable. Nowadays, this problem can be overcome by the implementation of a new technological procedure, which consists in the microencapsulation of the ferrous sulfate with lecithin, thus avoiding the interaction of iron with the food. The absorption obtained in mice for milk-ferrous sulfate was 7.9 +/- 3.2%, while for microencapsulated ferrous sulfate-milk the result was 11.6 +/- 4.5%. Comparing these data with those obtained with the ferrous ascorbate in water 13.1 +/- 4.9% and ferrous sulfate in water 13.2 +/- 4.3%, both of them considered as reference standards, no statistically significant difference between them and the microencapsulated ferrous sulfate in milk can be observed. However, this difference becomes significant (p < 0.01) when these products are compared to the non-encapsulated ferrous sulfate in milk. On the other hand, we demonstrated that this product is stable to heat-processing (100 degrees C, 30 min) and storage at a room temperature up to 6 months that lacteous products are usually submitted to.
- Published
- 1996
7. Contact dermatitis caused by dimethylfumarate in Argentina
- Author
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N. Kogan, A. Lo Balbo, Carlos A. Gotelli, W.P. Mac Cormack, and Mariano J. Gotelli
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Adult ,medicine.medical_specialty ,Miconazole ,Dimethyl Fumarate ,Argentina ,Toxicology ,Dermatitis, Contact ,Blister ,Fumarates ,Edema ,medicine ,Hypersensitivity ,Animals ,Humans ,skin and connective tissue diseases ,Epidemics ,Epidermal barrier ,integumentary system ,business.industry ,Foot ,Pruritus ,Blisters ,General Medicine ,Patch Tests ,medicine.disease ,Dermatology ,Anti-Bacterial Agents ,Fungicides, Industrial ,Shoes ,body regions ,Erythema ,Female ,Rabbits ,medicine.symptom ,Gentamicins ,business ,Contact dermatitis - Abstract
For the first time in Argentina, we describe an outbreak of contact dermatitis. New pairs of shoes caused intense pruritus, pain, and eruption, followed by edema, blisters, and a severe negative impact on the epidermal barrier of the feet. We identify dimethylfumarate as the causal agent and suggest an analytical method for its fast identification.
- Published
- 2011
8. Mercury Levels in Premature and Low Birth Weight Newborn Infants after Receipt of Thimerosal-Containing Vaccines
- Author
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Margarita Martin Alonso, Norberto Giglio, Grazyna Zareba, Lihan Yan, Angela Gentile, Carlos A. Gotelli, Mariano J. Gotelli, Thomas W. Clarkson, Michael E. Pichichero, Maria Veronica Fernandez Mentaberri, and John J. Treanor
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Male ,Pediatrics ,medicine.medical_specialty ,Birth weight ,Population ,Physiology ,chemistry.chemical_element ,Urine ,Injections, Intramuscular ,Article ,chemistry.chemical_compound ,medicine ,Humans ,Hepatitis B Vaccines ,Prospective Studies ,education ,education.field_of_study ,business.industry ,Thimerosal ,Preservatives, Pharmaceutical ,Infant, Newborn ,Mercury ,Infant, Low Birth Weight ,Mercury (element) ,Vaccination ,Low birth weight ,chemistry ,Pediatrics, Perinatology and Child Health ,Population study ,Female ,Thiomersal ,medicine.symptom ,business ,Infant, Premature ,Follow-Up Studies ,Half-Life - Abstract
We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born ator =32 and37 weeks of gestation and with birth weightor =2000 but3000 g.Blood, stool, and urine samples were obtained before vaccination and 12 hours to 30 days after vaccination from 72 premature newborn infants. Total mercury levels were measured by atomic absorption.The mean +/- standard deviation (SD) birth weight was 2.4 +/- 0.3 kg for the study population. Maximal mean +/- SD blood mercury level was 3.6 +/- 2.1 ng/mL, occurring at 1 day after vaccination; maximal mean +/- SD stool mercury level was 35.4 +/- 38.0 ng/g, occurring on day 5 after vaccination; and urine mercury levels were mostly nondetectable. The blood mercury half-life was calculated to be 6.3 (95% CI, 3.85 to 8.77) days, and mercury levels returned to prevaccination levels by day 30.The blood half-life of intramuscular ethyl mercury from thimerosal in vaccines given to premature infants is substantially shorter than that of oral methyl mercury in adults. Because of the differing pharmacokinetics, exposure guidelines based on oral methyl mercury in adults may not be accurate for children who receive thimerosal-containing vaccines.
- Published
- 2009
9. 710 Risk assessment for chromium exposure study of a population located in the province of Santa Fe Argentine Republic
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Mariano J. Gotelli, R. Castro, L. Signorini, Carlos A. Gotelli, D. Gotelli, A. Lo Balbo, and S. Britos
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education.field_of_study ,Chromium ,Geography ,chemistry ,Environmental protection ,Environmental health ,Population ,chemistry.chemical_element ,General Medicine ,Toxicology ,Risk assessment ,education - Published
- 2003
10. Early Biochemical Effects of an Organic Mercury Fungicide on Infants: 'Dose Makes the Poison'
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Christopher Cox, Elsa Cernichiari, Emilio Astolfi, Carlos A. Gotelli, and Thomas W. Clarkson
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Adult ,Urinary system ,Argentina ,chemistry.chemical_element ,Physiology ,Excretion ,Urinary excretion ,medicine ,Animals ,Humans ,Multidisciplinary ,Acrodynia ,Dose-Response Relationship, Drug ,Infant ,Mercury ,gamma-Glutamyltransferase ,Pesticide ,Phenylmercury Compounds ,medicine.disease ,Fungicides, Industrial ,Mercury (element) ,Fungicide ,Proteinuria ,Urodynamics ,chemistry ,Biochemistry ,Creatinine ,Mercury Poisoning ,Toxicity - Abstract
Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of gamma-glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a "threshold" value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. gamma-Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.
- Published
- 1985
11. Pesticides and Emergency Analytical Toxicology: A Comparative Study of the Different Analytical Methods Applied in the Detection of Pesticides
- Author
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Carlos A. Gotelli
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Engineering ,Resource (project management) ,Risk analysis (engineering) ,business.industry ,Analytical Toxicology ,Forensic engineering ,business - Abstract
Publisher Summary This chapter presents a comparative account on the different analytical methods applied in the detection of pesticides, focusing on emergency analytical toxicology. In the areas, the frequency of pesticide poisonings is increasing, but the possibility to establish adequately equipped laboratories is small and so is the availability of specialized professionals. From the emergency toxicology point of view, a basic criterion for the selection of an analytical method is the rapidity of the determination. The criteria for the selection of techniques include rapidity of the determination, sensitivity, and specificity. The toxicological emergency requires a quick and accurate laboratory. The medicosocial interest must be taken into account, because if not, one could get the paradox of not aiming for quick, economic, accurate, and easy diagnostic procedures thinking that only advanced instrumental analytical methods are the sole resource of the toxicological laboratory.
- Published
- 1982
12. Study of Public Health Secretariat Pesticide Applicators During the Anti-Malaria Campaign 1978
- Author
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E. Astolfi, A. Maccagno, Carlos A. Gotelli, and J. Higa de Landoni
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Toxicology ,medicine.medical_specialty ,business.industry ,Public health ,Metabolic effects ,Environmental health ,medicine ,Organochlorine pesticide ,Pesticide ,medicine.disease ,business ,Malaria - Abstract
Publisher Summary This chapter presents a study of public health secretariat pesticide applicators during the anti-malaria campaign 1978. In Argentina the Public Health Secretariat has been using different pesticides for many years to control the vectors of malaria and Chagas disease. Using some parts of the protocol VBC/75.9 of the Vector Biology and Control Division of WHO, a survey was designed to evaluate the hypothetic chronic effects of organochlorine pesticides in the last campaign against triatomides in 1978. Based on the study presented, the chapter investigates the degree of contamination between different groups of workers, that is, smokers vs. non-smokers, drinkers vs. non-drinkers, and protected vs. unprotected during the application of pesticides; and evaluates the possible enzyme and metabolic effects with emphasis on the presence of alpha fetoprotein. Results of serologic, enzyme, immunological and blood levels studies in exposed (n=48) and non-exposed (n=5) persons; and influence of protective clothing, smoking, and drinking on the concentration of chlorinated hydrocarbons in the blood of exposed people are presented.
- Published
- 1980
13. New procedure to fortify fluid milk and derivatives with iron: a comparative study in mice
- Author
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Mariano J. Gotelli, Ricardo A. Caro, José Boccio, Ricardo Weill, Marcela Zubillaga, and Carlos A. Gotelli
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SOY LECITHIN ,Nutrition and Dietetics ,Tea ,Chemistry ,Iron absorption ,Iron ,Fortification ,Phospholipid ,food and beverages ,Medicine (miscellaneous) ,Yogurt ,Coffee ,Bioavailability ,Absorption ,chemistry.chemical_compound ,Mice ,Milk ,Fluid milk ,Food, Fortified ,Animals ,Female ,Food science ,Ferrous Compounds ,Edible Grain - Abstract
It is known that the fortification of milk and its derivatives with iron has been recognized as a worldwide necessity, since the deficiency of this element produces different metabolic disorders. With this purpose, we have studied the iron absorption in mice after the administration of fluid milk and yogurt with FeSO4, stabilized by microencapsulation with soy lecithin (SFE-171) or with FeSO4, both labeled with 59Fe, which was used in the same experimental conditions for comparative purposes. The absorption of iron is influenced by the presence of some additives which usually are ingested together with milk, such as cacao, coffee, tea, "Argentine green herbs tea or maté" or cereals. The experimental results demonstrate that the iron absorption from SFE-171 is (12.3 +/- 2.9)%, whereas that from FeSO4 is (7.7 +/- 2.7)%, this difference is highly significant at p0.01. In all the cases, groups of 25 mice each were used to increase the statistical robustness of the experimental results. On the other hand, it could be demonstrated that the presence of 10% w/v cacao (Nesquik) increases the iron absorption in both cases, whereas 1% w/v cacao (Nesquik) and maté has no influence on the iron absorption if SFE-171 is used. Cereals (Nestum 3 cereals), yogurt and other additives like tea and coffee, for different reasons, decrease the absorption of this element.
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