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Early Biochemical Effects of an Organic Mercury Fungicide on Infants: 'Dose Makes the Poison'
- Source :
- Science. 227:638-640
- Publication Year :
- 1985
- Publisher :
- American Association for the Advancement of Science (AAAS), 1985.
-
Abstract
- Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of gamma-glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a "threshold" value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. gamma-Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.
- Subjects :
- Adult
Urinary system
Argentina
chemistry.chemical_element
Physiology
Excretion
Urinary excretion
medicine
Animals
Humans
Multidisciplinary
Acrodynia
Dose-Response Relationship, Drug
Infant
Mercury
gamma-Glutamyltransferase
Pesticide
Phenylmercury Compounds
medicine.disease
Fungicides, Industrial
Mercury (element)
Fungicide
Proteinuria
Urodynamics
chemistry
Biochemistry
Creatinine
Mercury Poisoning
Toxicity
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 227
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....7660fb369402ad4d047dfa3c42a53c2c