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Your search keyword '"Cardia -- Genetic aspects"' showing total 3 results
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3 results on '"Cardia -- Genetic aspects"'

1. Effects of phosphorylation and mutation R145G on human cardiac troponin I function

Author

Deng, Yi, Schmidtmann, Anja, Redlich, Alexander, Westerdorf, Barbara, Jaquet, Kornelia, and Thieleczek, Rolf

Subjects
Biochemistry -- Research, Phosphorylation -- Physiological aspects, Gene mutations -- Physiological aspects, Cardia -- Genetic aspects, Proteins -- Genetic aspects, Serine -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the human cardiac troponin I mutations. The effect of these mutations and the adjacent N-terminal serine residue phosphorylation on the wild-type human cardiac troponin I and the mutated proteins has been investigated and the results are reported.

Published
2001

2. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA

Author

Charron, Frederic, Tsimiklis, George, Arcand, Mathieu, Robitaille, Lynda, Liang, Qiangrong, Molkentin, Jeffrey D., Meloche, Sylvain, and Nemer, Mona

Subjects
Genetic research -- Analysis, Genetic transcription -- Regulation, Heart cells -- Genetic aspects, Cardia -- Genetic aspects, Biological sciences
Abstract

Research has been conducted on the RhoA-like GTPases. Results indicate that the transcription factor GATA-4, a cardiac gene regulator, is the RhoA signaling mediator and is involved in the sarcomere assembly control in cardiomyocytes.

Published
2001

3. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Author

Bruneau, Benoit G., Nemer, Georges, Schmitt, Joachim P., Charron, Frederic, Robitaille, Lynda, Caron, Sophie, Conner, David A., Gessler, Manfred, Nemer, Mona, Seidman, Christine E., and Seidman, J. G.

Subjects
Cell research -- Analysis, Genetic transcription -- Genetic aspects, Proteins -- Genetic aspects, Gene mutations -- Physiological aspects, Cardia -- Genetic aspects, Biological sciences
Abstract

Research has been conducted on the T-box proteins. The role of these proteins in cardiac development and the consequences of the TBX5 mutations have been investigated via the engineered mice containing a deletion in Tbx5 alleles and the results are discussed.

Published
2001

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