A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

Authors :: Bruneau, Benoit G.
Nemer, Georges
Schmitt, Joachim P.
Charron, Frederic
Robitaille, Lynda
Caron, Sophie
Conner, David A.
Gessler, Manfred
Nemer, Mona
Seidman, Christine E.
Seidman, J. G.
Source :: Cell. Sept 21, 2001, Vol. 106 Issue 6, p709, 14 p.
Publication Year :: 2001
Abstract: Research has been conducted on the T-box proteins. The role of these proteins in cardiac development and the consequences of the TBX5 mutations have been investigated via the engineered mice containing a deletion in Tbx5 alleles and the results are discussed.

Subjects :: Cell research -- Analysis
Genetic transcription -- Genetic aspects
Proteins -- Genetic aspects
Gene mutations -- Physiological aspects
Cardia -- Genetic aspects
Biological sciences

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