34 results on '"Capital Institute of Pediatrics, China"'
Search Results
2. The Effectiveness and Safety of Vagus Nerve Stimulation for TRE
- Author
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Beijing Tiantan Hospital, The First Hospital of Jilin University, Xuanwu Hospital, Beijing, Capital Medical University, Peking University First Hospital, China-Japan Friendship Hospital, Chinese PLA General Hospital, Fourth Medical Center of PLA General Hospital, Capital Institute of Pediatrics, China, The Second Hospital of Hebei Medical University, Xijing Hospital, First Affiliated Hospital Xi'an Jiaotong University, Children's Hospital of Fudan University, RenJi Hospital, Jining Medical University, Xiamen Humanity Hospital, Xiangya Hospital of Central South University, Wuhan Medical Care Center for Women and Children, Guangdong 999 Brain Hospital, Shenzhen Children's Hospital, Xinqiao Hospital, Army Medical University, West China Hospital, and Shuli Liang, Director of Functional Neurosurgery
- Published
- 2024
3. Registry of IgA Nephropathy in Chinese Children (RACC)
- Author
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Nanjing PLA General Hospital, Beijing Children's Hospital, Central South University, The Children's Hospital of Zhejiang University School of Medicine, First Affiliated Hospital, Sun Yat-Sen University, Tongji Hospital, Hunan Children's Hospital, Shanghai Children's Hospital, Nanjing Children's Hospital, Children's Hospital of Chongqing Medical University, Shandong Provincial Hospital, Fuzhou General Hospital, Second Affiliated Hospital of Wenzhou Medical University, Children's Hospital of Hebei Province, Guangzhou Women and Children's Medical Center, Jiangxi Province Children's Hospital, Guangzhou First People's Hospital, Xian Children's Hospital, Capital Institute of Pediatrics, China, The First Hospital of Jilin University, Wuhan Women and Children's Medical Center, Tianjin Children's Hospital, Chengdu Women's and Children's Central Hospital, The First People's Hospital of Yunnan, and Jie Ding, Prof.
- Published
- 2023
4. Real World App-based CCAAP Management of Children With Asthma
- Author
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Capital Institute of Pediatrics, China, Centers for Disease Control and Prevention, China, and Kunling Shen, Professor
- Published
- 2023
5. Long COVID Symptoms in SARS-CoV-2-positive Children in China
- Author
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Capital Institute of Pediatrics, China and Tim Shi, Director
- Published
- 2023
6. The Efficacy of Huaiqihuang Granule in Children With Primary Nephrotic Syndrome
- Author
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Capital Institute of Pediatrics, China
- Published
- 2022
7. the Effects of Air Pollution on Respiratory Diseases in Children
- Author
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Tianjin Children's Hospital, Jiangxi Province Children's Hospital, Wuhan Children's Hospital, Capital Institute of Pediatrics, China, First Affiliated Hospital of Xinjiang Medical University, Guangzhou Women and Children's Medical Center, The First Affiliated Hospital of Anhui Medical University, Shanxi Provincial Maternity and Children's Hospital, The First Affiliated Hospital of Xiamen University, Shenzhen Children's Hospital, Xian Children's Hospital, The First Affiliated Hospital of Guangzhou Medical University, China-Japan Friendship Hospital, Kunming Children's Hospital, Xianyang Children's Hospital, and Baoping XU, Chief of Respiratory Department Affiliation: Beijing Children's Hospital
- Published
- 2022
8. Clinical Feature and Microbiology Characteristics of Empyema in Children
- Author
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Capital Institute of Pediatrics, China, Tianjin Children's Hospital, Second Hospital affiliated with Tianjin Medical University, Children's Hospital of Hebei Province, Baoding Children's Hospital, and Baoping XU, Director of China National Clinical Research Center for Respiratory Diseases, Chief of Respiratory Department
- Published
- 2021
9. Prognosis and Integrative Assessment of Aortic Coarctation Patients in China
- Author
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Beijing Anzhen Hospital, Bayi Children's Hospital Affiliated to PLA Army General Hospital, China, and Capital Institute of Pediatrics, China
- Published
- 2020
10. Clinical Characteristics and Long-term Prognosis of 2019-nCoV Infection in Children
- Author
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Capital Institute of Pediatrics, China, The First Affiliated Hospital of Anhui Medical University, China-Japan Friendship Hospital, The First Affiliated Hospital of Xiamen University, Guangzhou Women and Children's Medical Center, Shenzhen Children's Hospital, First Affiliated Hospital of Guangxi Medical University, The Affiliated Hospital Of Guizhou Medical University, Hainan People's Hospital, Children's Hospital of Hebei Province, Wuhan Women and Children's Medical Center, Changchun Children's Hospital, Children's Hospital of Nanjing Medical University, Jiangxi Province Children's Hospital, Shengjing Hospital, Shanxi Provincial Maternity and Children's Hospital, Xian Children's Hospital, Children's Hospital of Chongqing Medical University, Tianjin Children's Hospital, Tianjin Medical University Second Hospital, Kunming Children's Hospital, Second Affiliated Hospital of Wenzhou Medical University, and Kunling Shen, Director of National Clinical Research Center for Respiratory Diseases, China
- Published
- 2020
11. Registry Study on Respiratory Monogenic Diseases in Chinese Children
- Author
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Capital Institute of Pediatrics, China, Shengjing Hospital, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, The Children's Hospital of Zhejiang University School of Medicine, Children's Hospital of Chongqing Medical University, The first clinical college of Guangzhou medical university, Guangzhou Women and Children's Medical Center, Yuying Children's Hospital of Wenzhou Medical University, and Kunling Shen, Beijing Children's Hospital
- Published
- 2018
12. Clinical Study on Chinese Children's Asthma Action Plan
- Author
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Tian Jing Children's Hospital, Capital Institute of Pediatrics, China, Peking University Third Hospital, Beijing Tsinghua Chang Gung Hospital, Tianjin Medical University Second Hospital, Peking University Bin Hai Hospital, The First Hospital of Qinhuangdao, Tangshan Maternal and Child Health Hospital, Children's Hospital of Hebei Province, and Kunling Shen, Chief of China National Clinical Research Center for Respiratory Diseases
- Published
- 2018
13. Beijing Children and Adolescents Metabolic Syndrome Study (BCAMS Study) (BCAMS)
- Author
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Capital Institute of Pediatrics, China, Beijing Chao Yang Hospital, and Ming Li, Professor
- Published
- 2018
14. Pediatric Primary Immunodeficiency Disease (PID) in China
- Author
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Capital Institute of Pediatrics, China, Shenzhen Children's Hospital, and Kunling Shen, Chief of China National Clinical Research Center for Respiratory Diseases
- Published
- 2018
15. Children-Adult Asthma Cohort Study in China
- Author
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Shengjing Hospital, Capital Institute of Pediatrics, China, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, China-Japan Friendship Hospital, Ruijin Hospital, Xiangya Hospital of Central South University, Beijing Chao Yang Hospital, and Kunling Shen, Chief of China National Clinical Research Center for Respiratory Diseases
- Published
- 2017
16. Registry Study on Cystic Fibrosis in Chinese Children
- Author
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Shengjing Hospital, Capital Institute of Pediatrics, China, Shanghai Children's Medical Center, Shenzhen Children's Hospital, The First Affiliated Hospital of Xiamen University, First Affiliated Hospital of Guangxi Medical University, and Kunling Shen, Chief of China National Clinical Research Center for Respiratory Diseases
- Published
- 2016
17. Registry Study on Primary Ciliary Dyskinesia in Chinese Children
- Author
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Shengjing Hospital, Capital Institute of Pediatrics, China, Shanghai Children's Medical Center, Shenzhen Children's Hospital, The First Affiliated Hospital of Xiamen University, First Affiliated Hospital of Guangxi Medical University, and Baoping XU, Chief of Respiratory Department
- Published
- 2016
18. Short and Long Term Effect of Early Infant Feeding and Nutritional Status on the Children's Health
- Author
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Capital Institute of Pediatrics, China, Peking University, and Beijing Ditan Hospital
- Published
- 2016
19. Research of Systemic Management for Late Preterm Infants Nutrition in China (NLP)
- Author
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Peking University First Hospital, Peking University People's Hospital, Peking University Third Hospital, Beijing Children's Hospital, Capital Institute of Pediatrics, China, Beijing Obstetrics and Gynecology Hospital, Beijing Huaxin Hospital, Beijing Friendship Hospital, Beijing Ditan Hospital, Bayi Children's Hospital Affiliated to Beijing Military Gen Hospital, Beijing Shangdi Hospital, Beijing Tongzhou District Maternal and Child Health Hospital, Beijing Yanqing County Hospital, People's Hospital of Beijing Daxing District, Beijing Hospital, Civil Aviation General Hospital, Beijing Anzhen Hospital, Military 301 Hospital, Beijing Haidian Maternal and Child Health Hospital, Beijing 302 Hospital, Beijing Chaoyang District Maternal and Child Health Hospital, China-Japan Friendship Hospital, Military 306 Hospital, Beijing Chao Yang Hospital, Navy General Hospital, Beijing, and Li zhenghong, associate professor
- Published
- 2015
20. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
- Author
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Ezzati, M. and Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Hajifathalian, K. and Taddei, C. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Bennett, J. and Bilano, V. and Stevens, G.A. and Cowan, M.J. and Riley, L.M. and Chen, Z. and Hambleton, I.R. and Jackson, R.T. and Kengne, A.P. and Khang, Y.-H. and Laxmaiah, A. and Liu, J. and Malekzadeh, R. and Neuhauser, H.K. and Sorić, M. and Starc, G. and Sundström, J. and Woodward, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R.J. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmad, N.A. and Ahmadvand, A. and Ahrens, W. and Ajlouni, K. and Akhtaeva, N. and Al-Raddadi, R. and Ali, M.M. and Ali, O. and Alkerwi, A. and Aly, E. and Amarapurkar, D.N. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L.H. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Arveiler, D. and Aryal, K.K. and Aspelund, T. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bamoshmoosh, M. and Banach, M. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Batyrbek, A. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bista, B. and Bjerregaard, P. and Bjertness, E. and Bjertness, M.B. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Borchini, R. and Bovet, P. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cai, H. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Chirlaque, M.-D. and Cho, B. and Cho, Y. and Christofaro, D.G. and Chudek, J. and Cifkova, R. and Cinteza, E. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and Davletov, K. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and de Oliveira, P.D. and De Smedt, D. and Deepa, M. and Dehghan, A. and Delisle, H. and Deschamps, V. and Dhana, K. and Di Castelnuovo, A.F. and Dias-da-Costa, J.S. and Diaz, A. and Dickerson, T.T. and Do, H.T.P. and Dobson, A.J. and Donfrancesco, C. and Donoso, S.P. and Döring, A. and Dorobantu, M. and Doua, K. and Drygas, W. and Dulskiene, V. and Džakula, A. and Dzerve, V. and Dziankowska-Zaborszczyk, E. and Eggertsen, R. and Ekelund, U. and El Ati, J. and Elliott, P. and Elosua, R. and Erasmus, R.T. and Erem, C. and Eriksen, L. and Eriksson, J.G. and Escobedo-de la Peña, J. and Evans, A. and Faeh, D. and Fall, C.H. and Farzadfar, F. and Felix-Redondo, F.J. and Ferguson, T.S. and Fernandes, R.A. and Fernández-Bergés, D. and Ferrante, D. and Ferrari, M. and Ferreccio, C. and Ferrieres, J. and Finn, J.D. and Fischer, K. and Föger, B. and Foo, L.H. and Forslund, A.-S. and Forsner, M. and Fouad, H.M. and Francis, D.K. and Franco, M.C. and Franco, O.H. and Frontera, G. and Fuchs, F.D. and Fuchs, S.C. and Fujita, Y. and Furusawa, T. and Gaciong, Z. and Galvano, F. and Garcia-de-la-Hera, M. and Gareta, D. and Garnett, S.P. and Gaspoz, J.-M. and Gasull, M. and Gates, L. and Geleijnse, J.M. and Ghasemian, A. and Ghimire, A. and Giampaoli, S. and Gianfagna, F. and Gill, T.K. and Giovannelli, J. and Goldsmith, R.A. and Gonçalves, H. and Gonzalez-Gross, M. and González-Rivas, J.P. and Gorbea, M.B. and Gottrand, F. and Graff-Iversen, S. and Grafnetter, D. and Grajda, A. and Grammatikopoulou, M.G. and Gregor, R.D. and Grodzicki, T. and Grøntved, A. and Grosso, G. and Gruden, G. and Grujic, V. and Gu, D. and Guan, O.P. and Gudmundsson, E.F. and Gudnason, V. and Guerrero, R. and Guessous, I. and Guimaraes, A.L. and Gulliford, M.C. and Gunnlaugsdottir, J. and Gunter, M. and Gupta, P.C. and Gupta, R. and Gureje, O. and Gurzkowska, B. and Gutierrez, L. and Gutzwiller, F. and Hadaegh, F. and Halkjær, J. and Hardy, R. and Kumar, R.H. and Hata, J. and Hayes, A.J. and He, J. and He, Y. and Hendriks, M.E. and Henriques, A. and Cadena, L.H. and Herrala, S. and Heshmat, R. and Hihtaniemi, I.T. and Ho, S.Y. and Ho, S.C. and Hobbs, M. and Hofman, A. and Dinc, G.H. and Horimoto, A.R. and Hormiga, C.M. and Horta, B.L. and Houti, L. and Howitt, C. and Htay, T.T. and Htet, A.S. and Htike, M.M.T. and Hu, Y. and Huerta, J.M. and Huisman, M. and Husseini, A.S. and Huybrechts, I. and Hwalla, N. and Iacoviello, L. and Iannone, A.G. and Ibrahim, M.M. and Wong, N.I. and Ikeda, N. and Ikram, M.A. and Irazola, V.E. and Islam, M. and al-Safi Ismail, A. and Ivkovic, V. and Iwasaki, M. and Jacobs, J.M. and Jaddou, H. and Jafar, T. and Jamrozik, K. and Janszky, I. and Jasienska, G. and Jelaković, A. and Jelaković, B. and Jennings, G. and Jeong, S.-L. and Jiang, C.Q. and Joffres, M. and Johansson, M. and Jokelainen, J.J. and Jonas, J.B. and Jørgensen, T. and Joshi, P. and Jóźwiak, J. and Juolevi, A. and Jurak, G. and Jureša, V. and Kaaks, R. and Kafatos, A. and Kajantie, E.O. and Kalter-Leibovici, O. and Kamaruddin, N.A. and Karki, K.B. and Kasaeian, A. and Katz, J. and Kauhanen, J. and Kaur, P. and Kavousi, M. and Kazakbaeva, G. and Keil, U. and Boker, L.K. and Keinänen-Kiukaanniemi, S. and Kelishadi, R. and Kemper, H.C.G. and Kengne, A.P. and Kerimkulova, A. and Kersting, M. and Key, T. and Khader, Y.S. and Khalili, D. and Khateeb, M. and Khaw, K.-T. and Kiechl-Kohlendorfer, U. and Kiechl, S. and Killewo, J. and Kim, J. and Kim, Y.-Y. and Klumbiene, J. and Knoflach, M. and Kolle, E. and Kolsteren, P. and Korrovits, P. and Koskinen, S. and Kouda, K. and Kowlessur, S. and Koziel, S. and Kriemler, S. and Kristensen, P.L. and Krokstad, S. and Kromhout, D. and Kruger, H.S. and Kubinova, R. and Kuciene, R. and Kuh, D. and Kujala, U.M. and Kulaga, Z. and Kumar, R.K. and Kurjata, P. and Kusuma, Y.S. and Kuulasmaa, K. and Kyobutungi, C. and Laatikainen, T. and Lachat, C. and Lam, T.H. and Landrove, O. and Lanska, V. and Lappas, G. and Larijani, B. and Laugsand, L.E. and Bao, K.L.N. and Le, T.D. and Leclercq, C. and Lee, J. and Lee, J. and Lehtimäki, T. and León-Muñoz, L.M. and Levitt, N.S. and Li, Y. and Lilly, C.L. and Lim, W.-Y. and Lima-Costa, M.F. and Lin, H.-H. and Lin, X. and Lind, L. and Linneberg, A. and Lissner, L. and Litwin, M. and Lorbeer, R. and Lotufo, P.A. and Lozano, J.E. and Luksiene, D. and Lundqvist, A. and Lunet, N. and Lytsy, P. and Ma, G. and Ma, J. and Machado-Coelho, G.L.L. and Machi, S. and Maggi, S. and Magliano, D.J. and Magriplis, E. and Majer, M. and Makdisse, M. and Malhotra, R. and Rao, K.M. and Malyutina, S. and Manios, Y. and Mann, J.I. and Manzato, E. and Margozzini, P. and Marques-Vidal, P. and Marques, L.P. and Marrugat, J. and Martorell, R. and Mathiesen, E.B. and Matijasevich, A. and Matsha, T.E. and Mbanya, J.N. and Posso, A.J.M.D. and McFarlane, S.R. and McGarvey, S.T. and McLachlan, S. and McLean, R.M. and McLean, S.B. and McNulty, B.A. and Mediene-Benchekor, S. and Medzioniene, J. and Meirhaeghe, A. and Meisinger, C. and Menezes, A.B. and Menon, G.R. and Meshram, I.I. and Metspalu, A. and Meyer, H.E. and Mi, J. and Mikkel, K. and Miller, J.C. and Minderico, C.S. and Miquel, J.F. and Miranda, J.J. and Mirrakhimov, E. and Mišigoj-Durakovic, M. and Modesti, P.A. and Mohamed, M.K. and Mohammad, K. and Mohammadifard, N. and Mohan, V. and Mohanna, S. and Yusoff, M.F.M.D. and Møllehave, L.T. and Møller, N.C. and Molnár, D. and Momenan, A. and Mondo, C.K. and Monyeki, K.D.K. and Moon, J.S. and Moreira, L.B. and Morejon, A. and Moreno, L.A. and Morgan, K. and Moschonis, G. and Mossakowska, M. and Mostafa, A. and Mota, J. and Motlagh, M.E. and Motta, J. and Msyamboza, K.P. and ThetMu, T. and Muiesan, M.L. and Müller-Nurasyid, M. and Murphy, N. and Mursu, J. and Musil, V. and Nabipour, I. and Nagel, G. and Naidu, B.M. and Nakamura, H. and Námešná, J. and Nang, E.K. and Nangia, V.B. and Narake, S. and Nauck, M. and Navarrete-Muñoz, E.M. and Ndiaye, N.C. and Neal, W.A. and Nenko, I. and Neovius, M. and Nervi, F. and Nguyen, C.T. and Nguyen, N.D. and Nguyen, Q.N. and Nguyen, Q.V. and Nieto-Martínez, R.E. and Niiranen, T.J. and Ning, G. and Ninomiya, T. and Nishtar, S. and Noale, M. and Noboa, O.A. and Noorbala, A.A. and Norat, T. and Noto, D. and Al Nsour, M. and O'Reilly, D. and Oda, E. and Oehlers, G. and Oh, K. and Ohara, K. and Olinto, M.T.A. and Oliveira, I.O. and Omar, M.A. and Onat, A. and Ong, S.K. and Ono, L.M. and Ordunez, P. and Ornelas, R. and Osmond, C. and Ostojic, S.M. and Ostovar, A. and Otero, J.A. and Overvad, K. and Owusu-Dabo, E. and Paccaud, F.M. and Padez, C. and Pahomova, E. and Pajak, A. and Palli, D. and Palmieri, L. and Pan, W.-H. and Panda-Jonas, S. and Panza, F. and Papandreou, D. and Park, S.-W. and Parnell, W.R. and Parsaeian, M. and Patel, N.D. and Pecin, I. and Pednekar, M.S. and Peer, N. and Peeters, P.H. and Peixoto, S.V. and Peltonen, M. and Pereira, A.C. and Peters, A. and Petersmann, A. and Petkeviciene, J. and Pham, S.T. and Pigeot, I. and Pikhart, H. and Pilav, A. and Pilotto, L. and Pitakaka, F. and Piwonska, A. and Plans-Rubió, P. and Polašek, O. and Porta, M. and Portegies, M.L.P. and Pourshams, A. and Poustchi, H. and Pradeepa, R. and Prashant, M. and Price, J.F. and Puder, J.J. and Puiu, M. and Punab, M. and Qasrawi, R.F. and Qorbani, M. and Bao, T.Q. and Radic, I. and Radisauskas, R. and Rahman, M. and Raitakari, O. and Raj, M. and Rao, S.R. and Ramachandran, A. and Ramos, E. and Rampal, L. and Rampal, S. and Rangel Reina, D.A. and Redon, J. and Reganit, P.M. and Ribeiro, R. and Riboli, E. and Rigo, F. and Rinke de Wit, T.F. and Ritti-Dias, R.M. and Robinson, S.M. and Robitaille, C. and Rodríguez-Artalejo, F. and Rodriguez-Perez, M.C. and Rodríguez-Villamizar, L.A. and Rojas-Martinez, R. and Romaguera, D. and Ronkainen, K. and Rosengren, A. and Roy, J.G.R. and Rubinstein, A. and Ruiz-Betancourt, B.S. and Rutkowski, M. and Sabanayagam, C. and Sachdev, H.S. and Saidi, O. and Sakarya, S. and Salanave, B. and Martinez, E.S. and Salmerón, D. and Salomaa, V. and Salonen, J.T. and Salvetti, M. and Sánchez-Abanto, J. and Sans, S. and Santos, D.A. and Santos, I.S. and Santos, R.N. and Santos, R. and Saramies, J.L. and Sardinha, L.B. and Sarganas, G. and Sarrafzadegan, N. and Saum, K.-U. and Savva, S. and Scazufca, M. and Schargrodsky, H. and Schipf, S. and Schmidt, C.O. and Schöttker, B. and Schultsz, C. and Schutte, A.E. and Sein, A.A. and Sen, A. and Senbanjo, I.O. and Sepanlou, S.G. and Sharma, S.K. and Shaw, J.E. and Shibuya, K. and Shin, D.W. and Shin, Y. and Si-Ramlee, K. and Siantar, R. and Sibai, A.M. and Silva, D.A.S. and Simon, M. and Simons, J. and Simons, L.A. and Sjöström, M. and Skovbjerg, S. and Slowikowska-Hilczer, J. and Slusarczyk, P. and Smeeth, L. and Smith, M.C. and Snijder, M.B. and So, H.-K. and Sobngwi, E. and Söderberg, S. and Solfrizzi, V. and Sonestedt, E. and Song, Y. and Sørensen, T.I.A. and Soric, M. and Jérome, C.S. and Soumare, A. and Staessen, J.A. and Stathopoulou, M.G. and Stavreski, B. and Steene-Johannessen, J. and Stehle, P. and Stein, A.D. and Stergiou, G.S. and Stessman, J. and Stieber, J. and Stöckl, D. and Stocks, T. and Stokwiszewski, J. and Stronks, K. and Strufaldi, M.W. and Sun, C.-A. and Sung, Y.-T. and Suriyawongpaisal, P. and Sy, R.G. and Tai, E.S. and Tammesoo, M.-L. and Tamosiunas, A. and Tan, E.J. and Tang, X. and Tanser, F. and Tao, Y. and Tarawneh, M.R. and Tarqui-Mamani, C.B. and Tautu, O.-F. and Taylor, A. and Theobald, H. and Theodoridis, X. and Thijs, L. and Thuesen, B.H. and Tjonneland, A. and Tolonen, H.K. and Tolstrup, J.S. and Topbas, M. and Topór-Madry, R. and Tormo, M.J. and Torrent, M. and Traissac, P. and Trichopoulos, D. and Trichopoulou, A. and Trinh, O.T.H. and Trivedi, A. and Tshepo, L. and Tulloch-Reid, M.K. and Tullu, F. and Tuomainen, T.-P. and Tuomilehto, J. and Turley, 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Health, Viet Nam, University of Turku, Finland, Universiti Putra Malaysia, Malaysia, University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Universidade Nove de Julho, Brazil, Public Health Agency of Canada, Canada, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, CIBER de Epidemiología y Salud Pública, Spain, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, The University of Tokyo, Japan, Samsung Medical Center, South Korea, Federal University of Santa Catarina, Brazil, St Vincent's Hospital, Australia, Academic Medical Center Amsterdam, Netherlands, University of Bari, Italy, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health- National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, Health Service of Murcia, Spain, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Hellenic Health Foundation, Greece, GovernmentMedical College, India, Sefako Makgatho Health Science University, South Africa, Addis Ababa University, Ethiopia, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, University of Tampere Tays Eye Center, Finland, Utrecht University, Netherlands, Hanoi University of Public Health, Viet Nam, Amsterdam Public Health Research Institute, Netherlands, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, North Karelian Center for Public Health, Finland, University of the Witwatersrand, South Africa, University of Strasbourg, France, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Capital Medical University, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Universitas Indonesia, Indonesia, National Institute of Public Health-National Institute of Hygiene, Poland, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, University of Cyprus, Cyprus, Universiti Teknologi MARA, Malaysia, Inner Mongolia Medical University, China, Universidad Politécnica de Madrid, Spain, State University of Montes Claros, Brazil, and University of Limpopo, South Africa
- Subjects
sense organs - Abstract
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups. © The Author(s) 2018.
- Published
- 2018
21. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
- Author
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and Garnett, S.P. and Gaspoz, J.-M. and Gasull, M. and Gates, L. and Gavrila, D. and Geleijnse, J.M. and Ghasemian, A. and Ghimire, A. and Giampaoli, S. and Gianfagna, F. and Giovannelli, J. and Goldsmith, R.A. and Gonçalves, H. and Gross, M.G. and González Rivas, J.P. and Gottrand, F. and Graff-Iversen, S. and Grafnetter, D. and Grajda, A. and Gregor, R.D. and Grodzicki, T. and Grøntved, A. and Gruden, G. and Grujic, V. and Guan, O.P. and Gudnason, V. and Guerrero, R. and Guessous, I. and Guimaraes, A.L. and Gulliford, M.C. and Gunnlaugsdottir, J. and Gunter, M. and Gupta, P.C. and Gureje, O. and Gurzkowska, B. and Gutierrez, L. and Gutzwiller, F. and Hadaegh, F. and Halkjær, J. and Hambleton, I.R. and Hardy, R. and Harikumar, R. and Hata, J. and Hayes, A.J. and He, J. and Hendriks, M.E. and Henriques, A. and Cadena, L.H. and Herqutanto and Herrala, S. and Heshmat, R. and Hihtaniemi, I.T. and Ho, S.Y. and Ho, S.C. and Hobbs, M. and Hofman, A. and Dinc, G.H. and Hormiga, C.M. and 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University of Edinburgh, United Kingdom, University College Dublin, Ireland, Penang Medical College, Malaysia, Institut National de la Santé et de la Recherche Médicale, France, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, University of Limpopo, South Africa, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, University of Brescia, Italy, Ulm University, Germany, Institute of Public Health, Malaysia, Kobe University, Japan, Suraj Eye Institute, India, INSERM, France, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, University of Bari, Italy, Zayed University, United Arab Emirates, University Medical Center Utrecht, Netherlands, Public Health Agency of Canada, Canada, Heart Institute, Brazil, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Vietnam National Heart Institute, Viet Nam, Federal Ministry of Health, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, University of New South Wales, Australia, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Alborz University of Medical Sciences, Iran, Turku University Hospital, Finland, Julius Centre University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, University of Madeira, Portugal, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Robert Koch Institut, Germany, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, Digestive Diseases Research Institute, Iran, The University of Tokyo, Japan, St Vincent's Hospital, Australia, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Heart Foundation, Australia, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health-National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Harvard T H Chan School of Public Health, United States, Hellenic Health Foundation, Greece, Government Medical College, India, Sefako Makgatho Health Science University, South Africa, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, University of Tampere Tays Eye Center, Finland, Centro di Prevenzione Cardiovascolare Udine, Italy, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, Centre for Research in Environmental Epidemiology, Spain, University of the Witwatersrand, South Africa, University of Strasbourg, France, University College Cork, Ireland, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Beijing Tongren Hospital, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, Chinese Center for Disease Control and Prevention, China, University of Cyprus, Cyprus, Ministry of Health, Malaysia, and Inner Mongolia Medical University, China
- Abstract
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license
- Published
- 2017
22. Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1.
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Li X, Cui J, Ding Z, Tian Z, Kong Y, Li L, Liu Y, Zhao W, Chen X, Guo H, Cui Z, Li X, Yuan J, and Zhang H
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- Humans, Animals, Male, Endothelium, Vascular metabolism, Superoxides metabolism, Sirtuin 1 metabolism, Extracellular Vesicles metabolism, Klebsiella pneumoniae physiology, Human Umbilical Vein Endothelial Cells
- Abstract
Background: The potential role of Klebsiella pneumoniae (K.pn) in hypertension development has been emphasized, although the specific mechanisms have not been well understood. Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions by delivering bacterial components to host cells. Endothelial dysfunction is an important early event in the pathogenesis of hypertension, yet the impact of K.pn-secreted EVs (K.pn EVs) on endothelial function remains unclear. This study aimed to investigate the effects of K.pn EVs on endothelial function and to elucidate the underlying mechanisms., Methods: K.pn EVs were purified from the bacterial suspension using ultracentrifugation and characterized by transmission electron microscopy nanoparticle tracking analysis, and EV marker expression. Endothelium-dependent relaxation was measured using a wire myograph after in vivo or ex vivo treatment with K.pn EVs. Superoxide anion production was measured by confocal microscopy and HUVEC senescence was assessed by SA-β-gal activity. SIRT1 overexpression or activator was utilized to investigate the underlying mechanisms., Results: Our data showed that K.pn significantly impaired acetylcholine-induced endothelium-dependent relaxation and increased superoxide anion production in endothelial cells in vivo. Similarly, in vivo and ex vivo studies showed that K.pn EVs caused significant endothelial dysfunction, endothelial provocation, and increased blood pressure. Further examination revealed that K.pn EVs reduced the levels of SIRT1 and p-eNOS and increased the levels of NOX2, COX-2, ET-1, and p53 in endothelial cells. Notably, overexpression or activation of SIRT1 attenuated the adverse effects and protein changes induced by K.pn EVs on endothelial cells., Conclusion: This study reveals a novel role of K.pn EVs in endothelial dysfunction and dissects the relevant mechanism involved in this process, which will help to establish a comprehensive understanding of K.pn EVs in endothelial dysfunction and hypertension from a new scope., Competing Interests: Declarations. Ethics approval and consent to participate: The animal procedures conducted in this study were ethically approved by the Animal Experimentation Ethics Committee of Capital Medical University. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)
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- 2025
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23. Geocultural differences in pre-schooler sleep profiles and family practices: an analysis of pooled data from 37 countries.
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Zhang Z, Abdeta C, Chelly MS, Del Pozo-Cruz J, Draper CE, Engberg E, Florindo A, Germana L, Ghofranipour F, Guan H, Ha AS, Hamdouchi AEL, Tang HK, Hossain MS, Jambaldorj B, Kim DH, Koh D, Kontsevaya A, Löf M, Lubree H, Jáuregui A, Munambah N, Mwase-Vuma T, Oluwayomi A, Pham BN, Reilly JJ, Staiano AE, Suherman A, Tanaka C, Tanui S, Teo WP, Tremblay MS, Turab A, Užičanin E, Veldman SLC, Webster EK, Wickramasinghe VP, Widyastari DA, and Okely A
- Abstract
Study Objectives: To examine 1) multidimensional sleep profiles in pre-schoolers (3-6 years) across geocultural regions and 2) differences in sleep characteristics and family practices between Majority World regions (Pacific Islands, Sub-Saharan Africa, Eastern Europe, Northeast Asia, Southeast Asia, South Asia, the Middle East and North Africa, Latin America) and the Minority World (the Western world)., Methods: Participants were 3507 pre-schoolers from 37 countries. Nighttime sleep characteristics and nap duration (accelerometer: n=1950) and family practices (parental questionnaire) were measured. Mixed models were used to estimate the marginal means of sleep characteristics by region and examine the differences., Results: Geocultural region explained up to 30% of variance in sleep characteristics. A pattern of short nighttime sleep duration, low sleep efficiency, and long nap duration was observed in Eastern Europe, Northeast Asia, and Southeast Asia. The second pattern, with later sleep midpoints and greater night-to-night sleep variability, was observed in South Asia, the Middle East and North Africa, and Latin America. Compared to the Minority World, less optimal sleep characteristics were observed in several Majority World regions, with medium-to-large effect sizes (∣d∣=0.48-2.35). Several Majority World regions reported more frequent parental smartphone use during bedtime routines (Northeast Asia, Southeast Asia: 0.77-0.99 units) and were more likely to have electronic devices in children's bedroom (Eastern Europe, Latin America, South Asia: OR=5.97-16.57) and co-sleeping arrangement (Asia, Latin America: OR=7.05-49.86), compared to the Minority World., Conclusions: Pre-schoolers' sleep profiles and related family practices vary across geocultural regions, which should be considered in sleep health promotion initiatives and policies., (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.)
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- 2024
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24. Elevated type I IFN signalling directly affects CD8 + T-cell distribution and autoantigen recognition of the skeletal muscles in active JDM patients.
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Huang B, Li H, Jiang Q, Li Y, Jiang Z, Cao H, Wang S, Wang X, Li J, and Li G
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- Humans, Animals, Mice, Female, Male, Child, Disease Models, Animal, Adolescent, Child, Preschool, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes metabolism, Interferon Type I metabolism, Muscle, Skeletal immunology, Muscle, Skeletal metabolism, Muscle, Skeletal pathology, Signal Transduction immunology, Autoantigens immunology, Dermatomyositis immunology, Dermatomyositis pathology, Dermatomyositis metabolism
- Abstract
The link between type I IFN and adaptive immunity, especially T-cell immunity, in JDM still remained largely unclear. This study aimed to understand the effect of elevated type I IFN signaling on CD8
+ T cell-associated muscle damage in juvenile dermatomyositis (JDM). This study used flow cytometry (FC) and RT‒PCR were used to examine the circulating cell ratio and type I IFN response. And scRNA-seq was used to examine peripheral immunity in 6 active JDM patients, 3 stable JDM patients, 3 juvenile IMNM patients and 3 age-matched healthy children. In vivo validation experiments were conducted using a mouse model induced by STING agonists and an experimental autoimmune myositis model (EAM). In vitro experiments were conducted using isolated CD8+ T-cells from JDM patients and mice. We found that active JDM patients showed an extensive type I IFN response and a decreased CD8+ T-cell ratio in the periphery (P < 0.05), which was correlated with muscle involvement (P < 0.05). Both new active JDM patients and all active JDM patients showed decreased CD8+ TCM cell ratios compared with age and gender matched stable JDM patients (P < 0.05). Compared with new pediatirc systemic lupus erythematosus (SLE) patients, new active JDM patients displayed decreased CD8+ T-cell and CD8+ TCM cell ratios (P < 0.05). Active JDM patient skeletal muscle biopsies displayed an elevated type I IFN response, upregulated MHC-I expression and CD8+ T-cell infiltration, which was validated in EAM mice. sc-RNAseq demonstrated that type I IFN signalling is the kinetic factor of abnormal differentiation and enhances the cytotoxicity of peripheral CD8+ T cells in active JDM patients, which was confirmed by in vivo and in vitro validation experiments. In summary, the elevated type I IFN signalling affected the differentiation and function of CD8+ T cells in active JDM patients. Skeletal muscle-infiltrating CD8+ T cells might migrate from the periphery under the drive of type I IFN and increased MHC I signals. Therapies targeting autoantigen-specific CD8+ T cells may represent a potential new treatment direction., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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25. Generation of a human iPSC line CIPi003-A from a patient with focal epilepsy harboring a heterozygous mutation in DEPDC5 gene.
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Shen M, Fan S, Wu F, Cheng P, Gao Y, Zheng P, Feng S, Ji X, Chen Q, and Zhang X
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- Child, Humans, Mutation genetics, Heterozygote, GTPase-Activating Proteins genetics, Induced Pluripotent Stem Cells metabolism, Epilepsies, Partial genetics, Epilepsies, Partial metabolism, Epilepsies, Partial pathology
- Abstract
The DEPDC5 gene (OMIM 614191) has been proven to be a frequent cause of familial and sporadic focal epilepsy. A human induced pluripotent stem cell (iPSC) line was generated from a child diagnosed with focal epilepsy, which was caused by DEDPC5 mutation. The iPSC line expresses high pluripotency markers, carries the DEDPC5 mutation, and can differentiate into three germ layers in vitro. The iPSC lines offer a promising technique for studying the pathogenesis and conducting drug screening of DEDPC5-related epilepsy., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2023
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26. Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process.
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Zhang Y, Li Q, Niu Y, Wei K, Wang X, Niu B, and Zhang L
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- Animals, Humans, Resveratrol pharmacology, Polyphenols pharmacology, Stem Cells, Mammals, Aging, Longevity
- Abstract
There have been many discussions on longevity from ancient times to the present day. In the Laozi, it is said, "Heaven and earth are long and enduring because they do not arise from themselves, so they can live forever." In Zhuangzi - Zai You, it is also said, "Keep your mental peace, and your body will be healthy. Don't strain your body and don't consume your spirit to live a long life." It is clear that people attach importance to anti-aging and the desire for longevity. Throughout human history, we have treated aging as an inevitable process, but with the development of medical science, we have become more aware of the various molecular changes in the human body. In an aging society, more people are suffering from age-related diseases such as osteoporosis, Alzheimer's disease, and cardiovascular disease, which has led to a search for anti-aging. However, by 'living longer' we mean not only living but also living longer in good health. The mechanisms of aging are still unclear and there is a great deal of interest and curiosity in how to combat aging effectively. Some potential criteria exist for the determination of anti-aging drugs: the first criterion is the ability to exert life-extending effects in model organisms, preferably in mammals; the second criterion is the ability to prevent or delay several age-related diseases in mammals; and the third criterion is the ability to inhibit the transition of cells from a quiescent to a senescent state. Based on these criteria, the current anti-aging drugs often involved are rapamycin, metformin, curcumin and other polyphenols, polysaccharides, resveratrol, etc. The most studied and relatively well-understood pathways and factors of aging are currently known to include seven enzymes, six biological factors, and one chemical, which mainly involve more than ten pathways such as Nrf2/SKN-1; NFκB; AMPK; P13K/AKT; IGF; and NAD., Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare., (Copyright © 2023. Published by Elsevier Inc.)
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- 2023
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27. Expert consensus on microtransplant for acute myeloid leukemia in elderly patients -report from the international microtransplant interest group.
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Ai H, Chao NJ, Rizzieri DA, Huang X, Spitzer TR, Wang J, Guo M, Keating A, Krakow EF, Blaise D, Ma J, Wu D, Reagan J, Gergis U, Duarte RF, Chaudhary PM, Hu K, Yu C, Sun Q, Fuchs E, Cai B, Huang Y, Qiao J, Gottlieb D, Schultz KR, Liu M, Chen X, Chen W, Wang J, Zhang X, Li J, Huang H, Sun Z, Li F, Yang L, Zhang L, Li L, Liu K, Jin J, Liu Q, Liu D, Gao C, Fan C, Wei L, Zhang X, Hu L, Zhang W, Tian Y, Han W, Zhu J, Xiao Z, Zhou D, Zhang B, Jia Y, Zhang Y, Wu X, Shen X, Lu X, Zhan X, Sun X, Xiao Y, Wang J, Shi X, Zheng B, Chen J, Ding B, Wang Z, Zhou F, Zhang M, Zhang Y, Sun J, Xia B, Chen B, and Ma L
- Abstract
Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment., (© 2023 The Authors.)
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- 2023
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28. Was Wuhan the early epicenter of the COVID-19 pandemic?-A critique.
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Cao Y, Chen L, Chen H, Cun Y, Dai X, Du H, Gao F, Guo F, Guo Y, Hao P, He S, He S, He X, Hu Z, Hoh BP, Jin X, Jiang Q, Jiang Q, Khan A, Kong HZ, Li J, Li SC, Li Y, Lin Q, Liu J, Liu Q, Lu J, Lu X, Luo S, Nie Q, Qiu Z, Shi T, Song X, Su J, Tao SC, Wang C, Wang CC, Wang GD, Wang J, Wu Q, Wu S, Xu S, Xue Y, Yang W, Yang Z, Ye K, Ye YN, Yu L, Zhao F, Zhao Y, Zhai W, Zhang D, Zhang L, Zheng H, Zhou Q, Zhu T, and Zhang YP
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- 2022
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29. Validity of low-cost measures for global surveillance of physical activity in pre-school children: The SUNRISE validation study.
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Mwase-Vuma TW, Janssen X, Okely AD, Tremblay MS, Draper CE, Florindo AA, Tanaka C, Koh D, Hongyan G, Tang HK, Chong KH, Löf M, Hossain MS, Cross P, Chathurangana PWP, and Reilly JJ
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- Female, Child, Preschool, Humans, Child, Male, Cross-Sectional Studies, Actigraphy, Costs and Cost Analysis, Accelerometry, Exercise
- Abstract
Objectives: To validate parent-reported child habitual total physical activity against accelerometry and three existing step-count thresholds for classifying 3 h/day of total physical activity in pre-schoolers from 13 culturally and geographically diverse countries., Design: Cross-sectional validation study., Methods: We used data involving 3- and 4-year-olds from 13 middle- and high-income countries who participated in the SUNRISE study. We used Spearman's rank-order correlation, Bland-Altman plots, and Kappa statistics to validate parent-reported child habitual total physical activity against activPAL™-measured total physical activity over 3 days. Additionally, we used Receiver Operating Characteristic Area Under the Curve analysis to validate existing step-count thresholds (Gabel, Vale, and De Craemer) using step-counts derived from activPAL™., Results: Of the 352 pre-schoolers, 49.1 % were girls. There was a very weak but significant positive correlation and slight agreement between parent-reported total physical activity and accelerometer-measured total physical activity (r: 0.140; p = 0.009; Kappa: 0.030). Parents overestimated their child's total physical activity compared to accelerometry (mean bias: 69 min/day; standard deviation: 126; 95 % limits of agreement: -179, 316). Of the three step-count thresholds tested, the De Craemer threshold of 11,500 steps/day provided excellent classification of meeting the total physical activity guideline as measured by accelerometry (area under the ROC curve: 0.945; 95 % confidence interval: 0.928, 0.961; sensitivity: 100.0 %; specificity: 88.9 %)., Conclusions: Parent reports may have limited validity for assessing pre-schoolers' level of total physical activity. Step-counting is a promising alternative - low-cost global surveillance initiatives could potentially use pedometers for assessing compliance with the physical activity guideline in early childhood., Competing Interests: Declaration of interest statement None., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2022
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30. Generation of a human induced pluripotent stem cell line (CIPi002-A) from an early infantile epileptic encephalopathy patient with a heterozygous mutation in SCN8A.
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Zhang P, Zheng P, Ji X, Gao Y, Zhang X, and Chen Q
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- Cell Culture Techniques, Cells, Cultured, Humans, Infant, Mutation genetics, NAV1.6 Voltage-Gated Sodium Channel genetics, NAV1.6 Voltage-Gated Sodium Channel metabolism, Epilepsy genetics, Induced Pluripotent Stem Cells metabolism, Intellectual Disability, Spasms, Infantile genetics
- Abstract
SCN8A is linked to early infantile epileptic encephalopathy type 13 (EIEE13). We generate a human induced pluripotent stem cell (iPSC) line from a child diagnosed with EIEE, caused by SCN8A variation. The iPSC line expresses high pluripotency markers, retains SCN8A variation and is able to differentiate into three germ layers in vitro. The iPSC lines will provide useful resources for studying the pathogenesis and drug screening of SCN8A-related epilepsy., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2022
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31. Generation of a human iPSC line CIPi001-A from a benign familial infantile epilepsy patient related 16p11.2 deletion.
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Ji X, Gao Y, Zhang P, Jin Z, Zhang Y, Yang M, Zhang X, and Chen Q
- Abstract
The features of 16p11.2 deletion phenotype is developmental delay, intellectual disability, and autism spectrum disorder. Seizures are observed in approximately 20% of individuals with the microdeletion. Induced pluripotent stem cells (iPSCs) were generated from erythroblasts obtained from a child diagnosed with benign familial infantile epilepsy, caused by 16p11.2 deletion. These iPSCs exhibited stable amplification, expressed pluripotent markers, and differentiated spontaneously into three germ layers in vitro., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
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- 2022
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32. Coxsackievirus B3 induces autophagy in HeLa cells via the AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways.
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Xin L, Ma X, Xiao Z, Yao H, and Liu Z
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- AMP-Activated Protein Kinases metabolism, Adenosine Triphosphate metabolism, Calcium metabolism, Cells, Cultured, Extracellular Signal-Regulated MAP Kinases metabolism, HeLa Cells, Humans, Membrane Potential, Mitochondrial, Mitochondria metabolism, Phagosomes metabolism, Autophagy, Enterovirus B, Human physiology, MAP Kinase Signaling System, Signal Transduction, raf Kinases metabolism, ras Proteins metabolism
- Abstract
In a previous study, the number of autophagosomes increased after coxsackievirus B3 (CVB3) infection. However, the exact mechanism by which CVB3 regulates the number of autophagosomes is unclear. Earlier studies have found that infection with CVB3 activates extracellular signal-regulated kinase (ERK). ERK is essential for CVB3 replication and can increase the number of autophagosomes. In the current study, extracellular signal-regulated kinase 1/2 was activated in HeLa cells after CVB3 infection. The ERK kinase inhibitor, U0126, was then used to inhibit the activity of ERK. Treatment with U0126 led to a significant reduction in the number of autophagosomes indicating that the CVB3-induced autophagosome accumulation may have occurred via the ERK pathway. The relationship between CVB3 infection and ERK pathway activation was also investigated. The results showed that the RasGAP protein could be further cleaved, leading to the activation of the Ras/Raf/MEK (mitogen/extracellular signal-regulated kinase)/ERK pathway and that CVB3 infection could result in an increase in the concentration of calcium in the cytoplasm, resulting in mitochondrial damage, a decrease in the concentration of ATP and activation of the AMPK (AMP-activated protein kinase)/MEK/ERK pathway. In summary, CVB3 might directly or indirectly induce autophagy via AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways in the host cells, representing a pivotal mechanism for CVB3 pathogenesis., (Copyright © 2015 Elsevier B.V. All rights reserved.)
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- 2015
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33. Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins.
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Xin L, Xiao Z, Ma X, He F, Yao H, and Liu Z
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- Cell Line, Coxsackievirus Infections genetics, Coxsackievirus Infections metabolism, Coxsackievirus Infections virology, Humans, Transcription, Genetic, Apoptosis, Autophagy, Caspases metabolism, Enterovirus B, Human physiology, Phagosomes metabolism, Phagosomes virology, Virus Release, Virus Replication
- Abstract
Coxsackievirus B3 (CVB3) is known to induce both autophagy and apoptosis, but whether a relationship exists between these processes upon infection, and whether and how they influence the viral life cycle are currently unknown. We observed here that while autophagosome formation increased in CVB3-infected HeLa cells at the early stage of infection, it decreased at the late stage of infection along with increased apoptosis. Examining whether a functional relationship existed between autophagy and apoptosis during CVB3 infection, we found that increasing levels of autophagy inhibited apoptosis and that some apoptotic proteins in the endogenous and exogenous apoptosis pathways played a role in the transition from autophagy to apoptosis by cleaving the autophagy-related proteins Beclin-1 and Atg5. However, the transcription and translation of full-length Atg5 and Beclin-1 also increased, which likely counteracted the cleavage effect in order to prevent cells from dying too early and to ensure that CVB3 replication was complete in the autophagosomes. Using pharmacological inducers and inhibitors of autophagy as well as inhibitors of apoptosis, we found that while CVB3 replication relied on the autophagosomes, its release from the cell depended on apoptosis. Therefore, autophagy and apoptosis are two important processes that interact with each other during CVB3 infection, promoting the CVB3 life cycle., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
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34. Combination of symptoms and oxygen desaturation index in predicting childhood obstructive sleep apnea.
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Chang L, Wu J, and Cao L
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- Child, Child, Preschool, Female, Humans, Infant, Logistic Models, Male, Polysomnography, ROC Curve, Retrospective Studies, Sensitivity and Specificity, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive physiopathology, Surveys and Questionnaires, Mass Screening methods, Oxygen analysis, Sleep Apnea, Obstructive diagnosis
- Abstract
Objective: To develop a screening process of obstructive sleep apnea in children based on a combination of symptoms and oxygen desaturation index (ODI)., Materials and Methods: We performed a retrospective study of 141 Chinese patients who were referred to a pediatric sleep laboratory for possible obstructive sleep apnea (OSA). The parents of each patient answered a questionnaire before their child underwent polysomnography (PSG) in the laboratory. An apnea-hypopnea index (AHI) greater than five on nocturnal PSG was defined as OSA. The nocturnal PSG was interpreted by a sleep laboratory physician. The ODI and occurrence ratio of sleep problems such as snoring, observable apnea during sleep, mouth breathing, and restless sleep, among others were compared between the OSA and non-OSA groups using the chi-square test. Items that indicated statistically significant differences were tested with non-parametric Spearman correlation tests to determine the correlation between these items and AHI. ODI and the items that indicated a statistically significant difference between the OSA and non-OSA groups were analyzed using binary logistic regression. The ODI cut-off point was determined through ODI receiver operating characteristic analysis to distinguish between OSA and non-OSA. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to determine the combination of OSA predictors that exhibited the best diagnostic performance., Results: Among the 141 patients, 78 (55%) were diagnosed with OSA by PSG. The occurrences of observable apnea during sleep, mouth breathing, and restless sleep were significantly different between the OSA and non-OSA groups (20.5% vs. 4.8%, 85.9% vs. 71.4%, 69.2% vs. 52.4%, respectively, with P<0.05). The median of ODI in the OSA group was significantly higher than that in the non-OSA group. The ODI and the occurrences of observable apnea during sleep, mouth breathing, and restless sleep were correlated with AHI and were important diagnostic factors of OSA in children, as determined through binary logistic regression. The presence of observable apnea during sleep had 95% specificity, 84% PPV, and 4.31 positive likelihood ratio (PLR). When score ≥3 (i.e., 3 or 4) was used as the cut-off point, specificity, PLR, and PPV were 0.86, 4.22, and 0.84, respectively. When score ≥2 was used as the as cut-off point, sensitivity, NLR, and NPV were 0.92, 0.2, and 0.80, respectively., Conclusions: Observable apnea during sleep was an independent positive predictive factor for OSA in children. A child with observable apnea during sleep should be referred to a special sleep laboratory for PSG diagnosis. When the total score is 3 or 4 based on a combination of symptoms and ODI, OSA can be diagnosed and the child should be referred to a sleep pediatrician for appropriate intervention. When the total score is 0 or 1, the child can be considered normal but should be monitored. When the total score is 2, the result cannot be determined and the child should be referred to a special sleep laboratory for PSG diagnosis. Thus, a screening process is developed based on a combination of symptoms and ODI., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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