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Objective: The current study discusses torsional wave transmission in a sandy layer across an orthotropic half-space. The interface that lies between the sandy layer and the half-space is governed by a non-linear function that describes the irregularity of the interface in a certain span along the horizontal axis. The inhomogeneity parameter associated with the media has been governed by a non-linear function as the composition of polynomial, exponential, and cosine functions of depth [Bullen (1940) in Bull. Seismol. Soc. Am. 235–250.]. Methodology: By means of suitable substitutions and variable-separable techniques, the displacement components have been derived in a closed form. The intrinsic boundary condition at the free surface and the interface have been imposed to deduce the dispersion relation. Two-dimensional graphs have been plotted for phase velocity against radial components to illustrate the influence of inhomogeneity parameters, initial stress, and rigidity ratios. Conclusion: The phase velocity of the torsional surface wave changes dramatically with respect to the various inhomogeneity parameters. The Biot's gravity parameter alters the velocity appreciably. [ABSTRACT FROM AUTHOR]

This study builds upon Johannes Bremer's thesis that the main theme of the Psalter is YHWH's concern for the poor (the so-called Armentheologie or theology of the poor). I argue that the phrase 'poor and needy' does not occur randomly through the Psalter but at strategic junctures. Traced from its inception to conclusion, seven Psalms (35, 37, 40, 70, 74, 86, 109) utilize this phrase to create a trajectory that moves from suffering to triumph, from oppression to deliverance, from denigration to vindication. Along this plotline, the psalmist identifies himself with the poor and needy in a way that grounds a messianic horizon for the Psalter, foreshadowing its consummation in Jesus Christ, the ultimate royal sage who promises 'blessing' (ashre) for the 'poor in spirit' who inherit the heavenly kingdom alongside the Psalter's poor petitioner (Psalm 72:8-14; Matthew 3:2; Luke 6:20). The Psalter thus provides hope in the midst of suffering, as the poor and needy praise God's name after deliverance and thank him for his abundant steadfast love, culminating in God's ultimate victory through their (eschatological) deliverance. [ABSTRACT FROM AUTHOR]

We investigate the oscillatory behavior of solutions of second‐order linear differential equations with impulses. These equations can be categorized into two types: canonical and non‐canonical. This study examines the canonical and non‐canonical impulsive differential equations in connection with the famous Leighton‐type oscillation theorem. The well‐known theorem states that every solution of (r(t)x′)′+p(t)x=0,t≥t0,$$ {\left(r(t){x}^{\prime}\right)}^{\prime }+p(t)x=0,\kern0.30em t\ge {t}_0, $$ where r$$ r $$ and p$$ p $$ are continuous with r(t)>0$$ r(t)>0 $$, is oscillatory if ∫t0∞dtr(t)=∞(canonical case),(*)$$ \kern3.4cm \int_{t_0}^{\infty}\frac{\mathrm{d}t}{r(t)}=\infty \kern0.30em \left(\mathrm{canonical}\ \mathrm{case}\right),\kern3.4cm \left(\ast \right) $$ and ∫t0∞p(t)dt=∞.(**)$$ \kern4.6cm \int_{t_0}^{\infty }p(t)\kern0.1em \mathrm{d}t=\infty .\kern4.3cm \left(\ast \ast \right) $$ This pioneering work of Leighton has received considerable attention since its inception, and hence, it has been extended to various types of equations, including delay differential equations, dynamic equations, and impulsive differential equations. There are also studies generalizing the Leighton oscillation theorem when the condition (∗)$$ \left(\ast \right) $$ fails, that is, when the equation is of non‐canonical type. Our work focuses on refining the Leighton oscillation theorem to treat the canonical and non‐canonical cases. By doing so, we correct, supplement, and enhance the current literature on the oscillation theory of differential equations with impulses. Examples are also given to illustrate the significance of the obtained results. [ABSTRACT FROM AUTHOR]

Robertson and Seymour proved two fundamental theorems about tangles in graphs: the tree-of-tangles theorem, which says that every graph has a tree-decomposition such that distinguishable tangles live in different nodes of the tree, and the tangle-tree duality theorem, which says that graphs without a \(k\)-tangle have a tree-decomposition that witnesses the non-existence of such tangles, in that \(k\)-tangles would have to live in a node but no node is large enough to accommodate one.Erde combined these two fundamental theorems into one, by constructing a single tree-decomposition such that every node either accommodates a single \(k\)-tangle or is too small to accommodate one. Such a tree-decomposition thus shows at a glance how many \(k\)-tangles a graph has and where they are.The two fundamental theorems have since been extended to abstract separation systems, which support tangles in more general discrete structures. In this paper we extend Erde's unified theorem to such general systems.Mathematics Subject Classifications: 05C83, 05C40, 06A07Keywords: Tree of tangles, tangle-tree duality, abstract separation system, submodularity, canonical

This paper investigates the oscillatory behavior of nonlinear third-order dynamic equations on time scales. Our main approach is to transform the equation from its semi-canonical form into a more tractable canonical form. This transformation simplifies the analysis of oscillation behavior and allows us to derive new oscillation criteria. These criteria guarantee that all solutions to the equation oscillate. Our results extend and improve upon existing findings in the literature, particularly for the special cases where $ \mathbb{T} = \mathbb{R} $ and $ \mathbb{T} = \mathbb{Z} $. Additionally, we provide illustrative examples to demonstrate the practical application of the developed criteria.

Classical curl forces are position-dependent Newtonian forces (accelerations) that are not the gradient of a scalar potential, and in general cannot be described by Hamiltonians. However, a special class of curl forces can be described by Hamiltonians, with the unusual feature that the kinetic energy is anisotropic in the momentum components. Therefore they can be quantised conventionally. We quantise the simplest such case: motion in the plane, with a curl force azimuthally directed and linear. As expected, the quantum propagator, and the way this drives Gaussian wavepackets, directly reflects the spiralling classical curl force dynamics. Two classes of stationary states—eigenfunctions of a continuous spectrum for the unbounded Hamiltonian—are described. They possess unusual singularities and an unfamiliar quantisation condition; their explanation requires asymptotics and unfamiliar singularities in the underlying families of classical trajectories. The analysis is supported and illustrated numerically. [ABSTRACT FROM AUTHOR]

Several factors that play a characteristic role in the formation of an individual are analyzed in the article. With reference to scientific, philosophical, psychological and other objects, the researches conducted directly around the family, school and state model were analyzed against the background of a unified consensus, comparisons were made, and the necessity of synergistic principles was highlighted. The author tried to analyze the importance of the listed formations as well as the negative manifestations that may arise from them, and tried to prove them with visual references. [ABSTRACT FROM AUTHOR]

This paper investigates the oscillatory behavior of nonlinear third-order dynamic equations on time scales. Our main approach is to transform the equation from its semi-canonical form into a more tractable canonical form. This transformation simplifies the analysis of oscillation behavior and allows us to derive new oscillation criteria. These criteria guarantee that all solutions to the equation oscillate. Our results extend and improve upon existing findings in the literature, particularly for the special cases where T = R and T = Z . Additionally, we provide illustrative examples to demonstrate the practical application of the developed criteria [ABSTRACT FROM AUTHOR]

Simple Summary: The Wnt signaling pathway plays a pivotal role in governing developmental processes and maintaining stem cell characteristics, while also exhibiting significant implications in cancer pathogenesis. While initially characterized in colorectal cancer, aberrations in Wnt signaling are pervasive across various cancer types. Both intrinsic and extrinsic factors modulate Wnt signaling, mainly influencing the strictly coordinated kinase cascade within Wnt signaling. Understanding the complex interplay of canonical and non-canonical Wnt pathways and their potential dysregulation in disorders holds promise for the development of innovative therapeutic strategies in cancer treatment. Since the initial identification of oncogenic Wnt in mice and Drosophila, the Wnt signaling pathway has been subjected to thorough and extensive investigation. Persistent activation of Wnt signaling exerts diverse cancer characteristics, encompassing tumor initiation, tumor growth, cell senescence, cell death, differentiation, and metastasis. Here we review the principal signaling mechanisms and the regulatory influence of pathway-intrinsic and extrinsic kinases on cancer progression. Additionally, we underscore the divergences and intricate interplays of the canonical and non-canonical Wnt signaling pathways and their critical influence in cancer pathophysiology, exhibiting both growth-promoting and growth-suppressing roles across diverse cancer types. [ABSTRACT FROM AUTHOR]

Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) and tau aggregates within the neuronal milieu. To prevent their neurotoxicity, these pathological aggregates will be cleared from the neuronal environment by extracellular, intracellular, and excretory mechanisms. As these compensatory mechanisms become overwhelmed, these left-behind aggregates will instigate neuronal loss via varied downstream signaling events. As a result, neurons undergo cell death through apoptosis and necrosis leading to the accumulation of cellular debris. Timely clearance of this cellular debris is critical, otherwise it can further potentiate neuronal loss by perpetuating pro-inflammatory environment. Results: Microglial cells migrate and engulf these dead neurons by a process known as canonical efferocytosis. On the other hand, normal living neurons will be cleared by microglial cells through extracellular exposure of phosphatidyl serine (PS) under the pathological influence of Aβ and tau through non-canonical efferocytosis. Canonical efferocytosis should be predominant with the absence of the non-canonical efferocytosis during the physiological conditions. Upregulation of cytokines, and chemokines in AD creates a fertile ground for the amplification of non-canonical efferocytosis in parallel to canonical efferocytosis. The preponderance of the non-canonical over canonical pathways leads to exuberant clearance of stressed and normal living neurons along with dead neurons, thereby leading to exacerbated neuronal loss, brain tissue thinning and severe cognitive disturbances in AD. Conclusions: Research efforts should be directed to understanding the factors that fine-tune the balance between these clearance processes. Novel therapeutic strategies that reinforce canonical efferocytosis will be beneficial by improving tissue repair, healing, and regeneration in AD. [ABSTRACT FROM AUTHOR]

The Morada Nova sheep breed is essential for the economy of the semi-arid region of Northeast Brazil, standing out for its adaptability, resistance to parasites and reproductive ability. However, the white variant is endangered, highlighting the importance of studies on its productivity to support conservation efforts. This study focuses on the growth curve of the Morada Nova sheep breed, using nonlinear models and analyzing flock profiles. Total of 764 observations of 165 animals from four farms in Ceará and Rio Grande do Norte, Brazil, were analyzed. Canonical discriminant analysis (CDA) was used for the exploratory analysis and four nonlinear models were used to study the growth curve. Weight from birth to 270 days of age, absolute growth rate (AGR), and the impact of sex on growth curves were assessed. Sex and farm are significant discriminating variables (P < 0.05) for the studied effects (weight and age). Weight was the primary phenotypic biomarker that discriminated between the two indicators, while age was a discriminating indicator only for the core effect. The Gompertz model was the most efficient, presenting the lowest residuals and greatest convergence. The study reveals new information about the growth of Morada Nova sheep, the white variety, including weight differences between the sexes at all analyzed ages and an inflection point before 90 days of age. These discoveries contribute to the understanding of the breed's growth and help in the formulation of conservation strategies. [ABSTRACT FROM AUTHOR]

In all cell types, small EVs, very abundant extracellular vesicles, are generated and accumulated within MVB endocytic cisternae. Upon MVB fusion and exocytosis with the plasma membrane, the EVs are released to the extracellular space. In the central nervous system, the release of neuronal EVs was believed to occur only from the surface of the body and dendrites. About 15 years ago, MVB cisternae and EVs were shown to exist and function at synaptic boutons, the terminals' pre- and post-synaptic structures essential for canonical neurotransmitter release. Recent studies have revealed that synaptic EVs are peculiar in many respects and heterogeneous with respect to other neuronal EVs. The distribution of synaptic EVs and the effect of their specific molecules are found at critical sites of their distribution. The role of synaptic EVs could consist of the modulation of canonical neurotransmitter release or a distinct, non-canonical form of neurotransmission. Additional roles of synaptic EVs are still not completely known. In the future, additional investigations will clarify the role of synaptic EVs in pathology, concerning, for example, circuits, trans-synaptic transmission, diagnosis and the therapy of diseases. [ABSTRACT FROM AUTHOR]

Biscuit bran (BB) is a co-product with worldwide distribution, with Brazil as the second largest cookie producer in the world with 1,157,051 tons. We evaluate the impact of completely replacing corn with BB on the characteristics and morphometry of carcass of purebred and crossbred Morada Nova lambs using machine learning techniques as an auxiliary method. Twenty male lambs from two genetic groups (GG) were used: purebred red-coated Morada Nova (MNR) and crossbred MNR × white-coated Morada Nova (MNF1). Supervised and unsupervised machine learning techniques were used. No interaction (P > 0.05) was observed between diets (D) and genetic groups (GG) and no simple isolated effect was observed for carcass characteristics, qualitative-quantitative typification of the Longissimus dorsi muscle, weight of non-carcass components, weight and yield of commercial cuts and carcass morphometric measurements. The formation of two horizontal clusters was verified: (i) crossed lambs with corn and BB and (ii) purebred lambs fed corn and BB. Vertically, three clusters were formed based on carcass and meat characteristics of native lambs: (i) thermal insulation, body capacity, true yield, and commercial cuts; (ii) choice, performance, physical carcass traits, and palatability; and (iii) yield cuts and non-carcass components. The heatmap also allowed us to observe that pure MN lambs had a greater body capacity when fed BB, while those fed corn showed superiority in commercial cuts, true yields, and non-carcass components. Crossbred lambs, regardless of diet, showed a greater association of physical characteristics of the carcass, performance, palatability, and less noble cuts. Crossbred lambs, regardless of diet, showed a greater association of physical characteristics of the carcass, performance, palatability, and less noble cuts. BB can be considered an alternative energy source in total replacement of corn. Integrating of machine learning techniques is a useful statistical tool for studies with large numbers of variables, especially when it comes to analyzing complex data with multiple effects in the search for data patterns and insights in decision-making on the farm. [ABSTRACT FROM AUTHOR]

The Verkhovna Rada adopted a generally revised draft law prohibiting the activity of religious organizations on the territory of Ukraine, particularly those related to the Russian Federation. There will be no Moscow church in Ukraine, the church in Ukraine will be deprived of Moscow influence. This event opened up a space for discussion, as a conscious citizen of Ukraine, a representative of the clergy, I cannot stand aside, I have been waiting for this event for 24 long years since my stay in the UAOC, and then without thinking I entered the united local Ukrainian Church of the OCU. Therefore, what happened before my eyes and what I myself directly suffered in the church environment during these years, I will add to the collected material with short comments. I will try to make an analysis of those materials that have recently appeared in various mass media on live broadcasts on television. Metropolitan Klimenta, the head of the information and educational department of the Ukrainian Orthodox Church of Ukraine, tries to claim that this law is no longer about the church itself, but about its property, that the Ukrainian Orthodox Church has no administrative ties with foreign centers, and they say that there is no Ukrainian document that would confirm this [ABSTRACT FROM AUTHOR]

Abstract Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs). Gut microbiota plays a pivotal role in maintaining gut homeostasis. Inflammasome activation needs to be tightly regulated to limit aberrant activation and bystander damage to the host cells. Several types of inflammasomes, including Node-like receptor protein family (e.g., NLRP1, NLRP3, NLRP6, NLRP12, NLRC4), PYHIN family, and pyrin inflammasomes, interact with gut microbiota to maintain gut homeostasis. This review discusses the current understanding of how inflammasomes and microbiota interact, and how this interaction impacts human health. Additionally, we introduce novel biologics and antagonists, such as inhibitors of IL-1β and inflammasomes, as therapeutic strategies for treating gastrointestinal disorders when inflammasomes are dysregulated or the composition of gut microbiota changes.

With self‐renewal and pluripotency features, embryonic stem cells (ESCs) provide an invaluable tool to investigate early cell fate decisions. Pluripotency exit and lineage commitment depend on precise regulation of gene expression that requires coordination between transcription (TF) and chromatin factors in response to various signaling pathways. SET domain‐containing 3 (SETD3) is a methyltransferase that can modify histones in the nucleus and actin in the cytoplasm. Through an shRNA screen, we previously identified SETD3 as an important factor in the meso/endodermal lineage commitment of mouse ESCs (mESC). In this study, we identified SETD3‐dependent transcriptomic changes during endoderm differentiation of mESCs using time‐course RNA‐seq analysis. We found that SETD3 is involved in the timely activation of the endoderm‐related gene network. The canonical Wnt signaling pathway was one of the markedly altered signaling pathways in the absence of SETD3. The assessment of Wnt transcriptional activity revealed a significant reduction in Setd3‐deleted (setd3∆) mESCs coincident with a decrease in the nuclear pool of the key TF β‐catenin level, though no change was observed in its mRNA or total protein level. Furthermore, a proximity ligation assay (PLA) found an interaction between SETD3 and β‐catenin. We were able to rescue the differentiation defect by stably re‐expressing SETD3 or activating the canonical Wnt signaling pathway by changing mESC culture conditions. Our results suggest that alterations in the canonical Wnt pathway activity and subcellular localization of β‐catenin might contribute to the endoderm differentiation defect of setd3∆ mESCs. [ABSTRACT FROM AUTHOR]

Robertson and Seymour constructed for every graph G a tree-decomposition that efficiently distinguishes all the tangles in G. While all previous constructions of these decompositions are either iterative in nature or not canonical, we give an explicit one-step construction that is canonical. The key ingredient is an axiomatisation of 'local properties' of tangles. Generalisations to locally finite graphs and matroids are also discussed. [ABSTRACT FROM AUTHOR]

This paper delves into the investigation of quasi-linear neutral differential equations in the third-order canonical case. In this study, we refine the relationship between the solution and its corresponding function, leading to improved preliminary results. These enhanced results play a crucial role in excluding the existence of positive solutions to the investigated equation. By building upon the improved preliminary results, we introduce novel criteria that shed light on the nature of these solutions. These criteria help to distinguish whether the solutions exhibit oscillatory behavior or tend toward zero. Moreover, we present oscillation criteria for all solutions. To demonstrate the relevance of our results, we present an illustrative example. This example validates the theoretical framework we have developed and offers practical insights into the behavior of solutions for quasi-linear third-order neutral differential equations. [ABSTRACT FROM AUTHOR]

This paper delves into the analysis of oscillation characteristics within third-order quasilinear delay equations, focusing on the canonical case. Novel sufficient conditions are introduced, aimed at discerning the nature of solutions—whether they exhibit oscillatory behavior or converge to zero. By expanding the literature, this study enriches the existing knowledge landscape within this field. One of the foundations on which we rely in proving the results is the symmetry between the positive and negative solutions, so that we can, using this feature, obtain criteria that guarantee the oscillation of all solutions. The paper enhances comprehension through the provision of illustrative examples that effectively showcase the outcomes and implications of the established findings. [ABSTRACT FROM AUTHOR]

In Gen 12–50 the interactions between the patriarchs and the Canaanites are more positive than in the later Hebrew Scriptures, with the exception of the ban on marriage. This article examines the relevant passages in Genesis (24; 26:34–28:9; 34 and especially 38), reading them canonically, particularly in light of the patriarchal promises which form a key underlying theme of the patriarchal narratives. It is argued that while the passages discourage exogamy, the situation is more complex than a simple ban. This is particularly so in the case of Tamar (Gen 38). While (probably) Canaanite she is the hero of the story and the ancestor of both David and Jesus, becoming an important part of the fulfilment of the promises. A brief comparison with the conquest narratives suggest that this complexity is also evident there, and that the focus is not on ethnicity but on one's attitude to YHWH. [ABSTRACT FROM AUTHOR]

Crossbreeding is carried out with the aim of enhancing and combining favorable traits between different breeds. The results of crossbreeding can be analyzed through genetic distance measured by various parameters, including morphometric measurements of livestock bodies. This study aims to analyze the morphometric diversity based on body measurements and canonical analysis in PE, Saanen, and Sapera goats to determine their genetic proximity. The research utilized a quantitative descriptive method using primary and secondary data from the BALITNAK Ciawi dairy goat station through a canonical analysis approach. The study and collection of primary and secondary data were conducted from March to April 2022. The research was carried out at the BALITNAK Dairy Goat Research Station in Ciawi Subdistrict, Bogor Regency. The results of this study indicate that the genetic distance between Sapera and Saanen goats is closer than between Sapera and PE goats. Furthermore, in terms of body measurements, the measurements of Sapera goats are closer to the Saanen goats compared to the PE goats. It can be concluded that the body size of Sapera goats is more similar to that of PE goats, while their external appearance is closer to the Saanen goats, which have predominantly white fur color. [ABSTRACT FROM AUTHOR]

Programmed cell death pathways play important roles in a wide variety of physiological processes. Although it has similarities with apoptosis pyroptosis is a different type of programmed cell death. Pyroptosis can be triggered by different molecules originating from the cells or their environment. Once a pyroptotic pathway is started, it is followed by different molecular steps, and, it ends with the disruption of cell membrane integrity and the onset of inflammatory processes. In addition to the role of pyroptosis in the host's innate immunity against pathogens, uncontrolled pyroptosis can lead to increased inflammation and lead various diseases. The contradictory role of pyroptosis-related molecular changes in the pathogenesis of cancer has attracted attention lately. Excessive or decreased expression of molecules involved in pyroptotic pathways is associated with various cancers. There are ongoing studies on the use of different treatment methods for cancer in combination with new therapies targeting pyroptosis. The potential beneficial effects or side-effect profiles of these protocols targeting pyroptosis still need to be investigated. This will provide us with more efficient and safer options to treat cancer. This review aims to overview the main pathways and mechanisms of pyroptosis and to discuss its role in cancer. [ABSTRACT FROM AUTHOR]

This paper delves into the investigation of quasi-linear neutral differential equations in the third-order canonical case. In this study, we refine the relationship between the solution and its corresponding function, leading to improved preliminary results. These enhanced results play a crucial role in excluding the existence of positive solutions to the investigated equation. By building upon the improved preliminary results, we introduce novel criteria that shed light on the nature of these solutions. These criteria help to distinguish whether the solutions exhibit oscillatory behavior or tend toward zero. Moreover, we present oscillation criteria for all solutions. To demonstrate the relevance of our results, we present an illustrative example. This example validates the theoretical framework we have developed and offers practical insights into the behavior of solutions for quasi-linear third-order neutral differential equations.

Scholars and critics that gauge Lin-Manuel Miranda’s hit musical Hamilton in terms of its historical accuracy or inaccuracy miss the point about Miranda’s creative endeavor. Hamilton represents a highly visible example of what might be called “Founders fanfiction”; although the musical is rooted deeply in historical fact, primarily via Ron Chernow’s magisterial biography of Hamilton, nonetheless, as a narrative the production is a piece of popular wish-fulfilment. Certainly, the show elides or ignores some of his more unpalatable characteristics, such as his deep elitism and love of military display and power. The elaboration of certain aspects of one’s character over another is a practice common to the creative endeavor of fanfiction. In fanfic, writers often create idealized or otherwise fantastical versions of beloved media characters, placing them in situations unreflective of the traditionally established narrative. This practice lets fanfic creators craft their own narratives with their own sense of agency and identity and make them more meaningful. Miranda performs the same kind of narrative reshaping of Hamilton’s life to conform to a particular view of Hamilton, much as historians and authors before him have done in the creation of what is known as “Founders chic”—the stressing of American Founders’ virtues and character at the expense of historical dimensionality and reality. Furthermore, the play has itself become a source of multiple instances of fanfiction, signifying significant emotional connections in the story that reflect Miranda’s own self-identification with Hamilton.

Scholars and critics that gauge Lin-Manuel Miranda's hit musical Hamilton in terms of its historical accuracy or inaccuracy miss the point about Miranda's creative endeavor. Hamilton represents a highly visible example of what might be called "Founders fanfiction"; although the musical is rooted deeply in historical fact, primarily via Ron Chernow's magisterial biography of Hamilton, nonetheless, as a narrative the production is a piece of popular wish-fulfilment. Certainly, the show elides or ignores some of his more unpalatable characteristics, such as his deep elitism and love of military display and power. The elaboration of certain aspects of one's character over another is a practice common to the creative endeavor of fanfiction. In fanfic, writers often create idealized or otherwise fantastical versions of beloved media characters, placing them in situations unreflective of the traditionally established narrative. This practice lets fanfic creators craft their own narratives with their own sense of agency and identity and make them more meaningful. Miranda performs the same kind of narrative reshaping of Hamilton's life to conform to a particular view of Hamilton, much as historians and authors before him have done in the creation of what is known as "Founders chic"--the stressing of American Founders' virtues and character at the expense of historical dimensionality and reality. Furthermore, the play has itself become a source of multiple instances of fanfiction, signifying significant emotional connections in the story that reflect Miranda's own self-identification with Hamilton. [ABSTRACT FROM AUTHOR]

Bishop Teofil Herineanu (who later became archbishop), belongs to the category of Transylvanian personalities who militated for the interests of Romanians in quite turbulent times, and the moment of starting his ecclesiastical activity, the political situation was unfavorable, taking place at time in which there were significant changes in all respects for the Church and the Nation; namely the second half of the twentieth century, a period that culminated with the establishment of communism. Being a bishop in those troubled years in which the Christian faith was long challenged by the new leadership of the state, and yet to stand upright, animating and comforting a sad and troubled people was not an easy mission for Herineanu. Bishop Teofil, "the man of prayer and compassion" was put in front of such trials, and he succeeded to remain in the memory of the faithful of Cluj as a reliable support. After a brief biography of this ecclesiastical personality, the aspects related to philanthropy will be highlighted, as well as the missionary activity carried aut by Teofil Herineanu both as bishop of Roman and Huși, and as archbishop of Vad, Feleac and Cluj. Converting to orthodoxy in the context of the changes that took place in 1948, throughout his pastorate as a bishop of Roman and Huși, as well as his pastorate as archbishop of Vad, Feleac and Cluj, Teofil Herineanu was noted for his many acts of philanthropy towards the poor, sick and helpless. He also helped the families of priests in communist prisons and to windows and orphans who asked for his support. [ABSTRACT FROM AUTHOR]

Abstract Introduction: cell's correct functionality and surveillance are brokered by a wide range of essential proceedings. The delicate equilibrium required between those phenomenon means that an error in the control mechanisms provoke the carcinogenesis commencement. In those metabolic pathways in charge of controlling the mechanisms are found the Wnt signaling pathways. Therefore, molecules that interact with the pathways mentioned, where secreted Frizzled - Related Protein 4 is located, will play a key role in the pathology knowledge. Method: a bibliographic research has been done in referral databases, such as Medline and Scopus. Results: sFRP4 has been identified as a negative modulator of the Wnt signaling pathways. This is due to its capacity of competing for the Wnt ligands and avoiding the commencement of the pathways. Otherwise, sFRP4 is essential for the control of the cancer beginning and development in those tissues where the protein is expressed, being mammary tissues considered into them. Conclusions: recent studies about the implications of sFRP4 in the development of several pathologies justify that the protein had garnered attention in recent years. Furthermore, it can be affirmed that sFRP4 presents an interesting potential as biomarker in the breast cancer treatment, diagnosis and prognosis, among other pathologies.

This study aims to find out whether the Rongga language (hereinafter abbreviated as bR) is a vocal language, and the reasons why bR is said to be a vocal language. This study uses a qualitative method. Data was collected using observation methods, field linguistics, literature assisted by elicitation techniques, record keeping, and recording. Data were analyzed qualitatively and presented descriptively. Based on the results of this study it was found that bR is a vocal language. This is based on (1) segmentation the series of letters , , constitute a sound segment: labial prenasal inhibition [ᵐb], alveolar prenasal inhibition [ⁿd], and velar prenasal inhibition [ᵑg] so that the word -words in bR like are pronounced as [ᵐbalu] 'storm', [ⁿdate] 'create', and [ᵑgare] 'gali', and are not pronounced as [ǝmbalu], [ǝndate], and [ǝngare]. (2) Based on the canonical pattern of syllables and words, bR has a canonical pattern that always ends in a vowel, and, (3) every word from the Indonesian language that ends in a consonant, both in the middle and final positions of syllables and words when absorbed in bR always conforms to the canonical pattern of bR syllables and words. For example, [paɠa].'fence', [aɗa] 'custom', [gapa] 'easy'. Thus, the Rongga language is a vocalic language. Abstrak Penelitian ini bertujuan untuk mengetahui apakah bahasa Rongga (selanjutnya disingkat bR) merupakan bahasa vokalik, dan alasan bR mengapa dikatakan sebagai bahasa vokalik. Penelitian ini menggunakan metode kualitatif. Data dikumpulkan dengan menggunakan metode observasi, linguistik lapangan, kepustakaan dibantu teknik elisitasi, pencatatan, dan perekaman. Data dianalisis secara kualitatif dan disajikan secara deskriptif. Berdasarkan hasil penelitian ini ditemukan bahwa ternyata bR merupakan bahasa vokalik. Hal ini didasarkan pada (1) secara segmentasi rangkaian huruf , , merupakan sebuah segmen bunyi: hambat pranasal labial [ᵐb], hambat pranasal alveolar [ⁿd], dan hambat pranasal velar [ᵑg] sehingga kata-kata dalam bR seperti dilafalkan sebagai [ᵐbalu] ‘badai’, [ⁿdate] ‘buat’, dan [ᵑgare] ‘gali’, dan tidak dilafalkan sebagai [ǝmbalu], [ǝndate], dan [ǝnggare]. (2) Secara pola kanonik sukukata dan kata, bR mempunyai pola kanonik yang selalu berakhir dengan vokal, dan, (3) setiap kata dari bahasa Indonesia yang berakhir dengan konsonan, baik pada posisi tengah maupun akhir sukukata dan kata ketika terserap dalam bR selalu menyesuaikan diri dengan pola kanonik sukukata dan kata bR. Contohnya [paɠa].’pagar’, [aɗa] ‘adat’, [gapa] ‘gampang’. Dengan demikian, bahasa Rongga merupakan bahasa vokalik.

This paper delves into the analysis of oscillation characteristics within third-order quasilinear delay equations, focusing on the canonical case. Novel sufficient conditions are introduced, aimed at discerning the nature of solutions—whether they exhibit oscillatory behavior or converge to zero. By expanding the literature, this study enriches the existing knowledge landscape within this field. One of the foundations on which we rely in proving the results is the symmetry between the positive and negative solutions, so that we can, using this feature, obtain criteria that guarantee the oscillation of all solutions. The paper enhances comprehension through the provision of illustrative examples that effectively showcase the outcomes and implications of the established findings.

The Signal Transducer and Activator of Transcription (STAT) family of transcription factors is involved in inflammation, immunity, development, cancer, and response to injury, among other biological phenomena. Canonical STAT signaling is often represented as a 3‐step pathway involving the sequential activation of a membrane receptor, an intermediate kinase, and a STAT transcription factor. The rate‐limiting phosphorylation at a highly conserved C‐terminal tyrosine residue determines the nuclear translocation and transcriptional activity of STATs. This apparent simplicity is actually misleading and can hardly explain the pleiotropic nature of STATs, the existence of various noncanonical STAT pathways, or the key role of the N‐terminal domain in STAT functions. More than 80 post‐translational modifications (PTMs) have been identified for STAT3, but their functions remain barely understood. Here, we provide a brief but comprehensive overview of these underexplored PTMs and their role on STAT3 canonical and noncanonical functions. A less tyrosine‐centric point of view may be required to advance our understanding of STAT signaling. [ABSTRACT FROM AUTHOR]

The abnormal expression of nuclear factor kappa B (NF-κB) target genes is closely related to the occurrence, metastasis, and invasion of tumor cells and is an inhibitor of their apoptosis. In recent years, the unique biodiversity in the marine environment has aroused great interest. Many studies indicate that some marine compounds exert anticancer effects on most common human tumors by modulating the NF-κB signaling pathway. In this study, 26 marine compounds that reduce cancer cell survival by suppressing the NF-κB signaling pathway were reviewed. They were derived from a wide range of sources, including sponges, fungi, algae and their derivatives or metabolites. These marine compounds exert antitumor effects through the canonical, noncanonical and atypical NF-κB signaling pathways; however, most of their anticancer targets and mechanisms remain unclear, and more research is needed in the future. Our article provides comprehensive information for researchers investigating the bioactivities of marine compounds and developing marine-derived anticancer drugs. [ABSTRACT FROM AUTHOR]

The aim of this study was to understand the temporal and spatial distribution of canonical endochondral ossification (CEO) and non-canonical endochondral ossification (NCEO) of the normal growing rat condyle, and to evaluate their histomorphological changes following the simultaneous hypotrophy of the unilateral masticatory closing muscles with botulinum toxin (BTX). 46 rats at postnatal 4 weeks were used for the experiment and euthanized at postnatal 4, 8, and 16 weeks. The right masticatory muscles of rats in experimental group were injected with BTX, the left being injected with saline as a control. The samples were evaluated using 3D morphometric, histological, and immunohistochemical analysis with three-dimensional regional mapping of endochondral ossifications. The results showed that condylar endochondral ossification changed from CEO to NCEO at the main articulating surface during the experimental period and that the BTX-treated condyle presented a retroclined smaller condyle with an anteriorly-shifted narrower articulating surface. This articulating region showed a thinner layer of the endochondral cells, and a compact distribution of flattened cells. These were related to the load concentration, decreased cellular proliferation with thin cellular layers, reduced extracellular matrix, increased cellular differentiation toward the osteoblastic bone formation, and accelerated transition of the ossification types from CEO to NCEO. The results suggest that endochondral ossification under loading tended to show more NCEO, and that masticatory muscular hypofunction by BTX had deleterious effects on endochondral bone formation and changed the condylar growth vector, resulting in a retroclined, smaller, asymmetrical, and deformed condyle with thin cartilage. • spatial and temporal patterns of endochondral ossification in growing rat condyle. • normal transition from canonical to non-canonical endochondral ossification under loading over time. • accelerated endochondral transition due to BTX-induced masticatory muscular hypofunction. • retroclined condyle with anteriorly shifted narrower articulating surface following BTX treatment. [ABSTRACT FROM AUTHOR]

The present contribution bears an attempt to take a novel synchronic perspective on derivational morphology in Persian namely canonical derivation. Introduced by Corbett (2010) and being a sub branch of canonical typology approach, canonical derivation viewpoint looks for canonical instances of single grammatical categories which are the best, the clearest and the indisputable ones rendering spectacular typological definitions. In this paper, by analyzing (195) derivational affixes including (22) prefixes and (173) suffixes, we endeavored to discover whether derivational morphology is canonical in Persian or the derivational affixes are far from canonicity in some degrees. The data analysis revealed that (%34) of derivational affixes rejected the substitutability criterion and just one suffix rejected 2 criteria. In sum, among 975 points for the fully canonical system, Persian gained 904which portrayed (%7.29) deviation from the canon; in other words, it is (%93) canonical. This amount of canonicity illustrates that derivation system in Persian is so close to the canonicity of derivation systems worldwide.

This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.This paper is an attempt to find out the canonical meaning of the insertion of the text of Deuteronomy 1: 1-8 in the overall framework of Deuteronomy. The method used in this research is canonical hermeneutics developed by Brevard S. Childs, this approach enables the interpreter to see the intent of the editor of the Scriptures in the preparation of text sequences in such a way as to the perspective of the final canon. The canonical analysis shows that Deuteronomy 1: 1-8 is the initial part of the minor form (chapters 1-4) that is deliberately inserted and placed at the front as a close link to the previous book (even the first four books of the holy book) and is both an introduction and legitimacy of authority Deuteronomy even for the whole Deuteronomic History. This text comes from the editor of the exile and gives a message of new hope for the exiled Israeli community.

Abstract Vine copula had a great impact on the study and analysis of dependence structures in various sciences. In multivariate analyses with dimensions of more than two variables, it is associated with computational complexities that solve vine copulas and these problems. In this study, in order to provide an approach to simulate potential evapotranspiration based on meteorological parameters in Birjand meteorological station from different family copulas including R‐vine, independent R‐vine, Gaussian, independent Gaussian, C‐vine, C‐vine independent, D‐vine and D‐vine independent were used. In this regard, vine copula simulation and conditional density were used. In pair correlation analysis of the studied variables using Kendall's tau statistic, dependence structure confirmed the studied parameters. The results showed a minimum correlation of −0.32 and a maximum of 0.77. The results of Akaike's information criteria (AIC), Bayesian information criteria (BIC) and LogLike statistics in evaluating the performance of vine copula dependency structure introduced the C‐vine copula as the superior copula for analysing the pair dependence of the studied variables. By introducing the superior dependency structure and internal copulas, the tree sequence of the pair of values under study was obtained. Pair of simulated values was performed using vine copula. Comparison of Kendall's tau values in both simulation and observation modes showed that Kendall's tau values were close to each other in both modes and were approximately similar. The simulation results of vine copula potential evapotranspiration values and precipitation, temperature and relative humidity values showed 92% efficiency. The efficiency of C‐vine copula in dependence analysis and simulation of potential evapotranspiration (PET) values is very high, which shows the ability of vine family copulas in multivariate analysis.

Introduction: cell’s correct functionality and surveillance are brokered by a wide range of essential proceedings. The delicate equilibrium required between those phenomenon means that an error in the control mechanisms provoke the carcinogenesis commencement. In those metabolic pathways in charge of controlling the mechanisms are found the Wnt signaling pathways. Therefore, molecules that interact with the pathways mentioned, where secreted Frizzled – Related Protein 4 is located, will play a key role in the pathology knowledge. Method: a bibliographic research has been done in referral databases, such as Medline and Scopus. Results: sFRP4 has been identified as a negative modulator of the Wnt signaling pathways. This is due to its capacity of competing for the Wnt ligands and avoiding the commencement of the pathways. Otherwise, sFRP4 is essential for the control of the cancer beginning and development in those tissues where the protein is expressed, being mammary tissues considered into them. Conclusions: recent studies about the implications of sFRP4 in the development of several pathologies justify that the protein had garnered attention in recent years. Furthermore, it can be affirmed that sFRP4 presents an interesting potential as biomarker in the breast cancer treatment, diagnosis and prognosis, among other pathologies. [ABSTRACT FROM AUTHOR]

Vine copula had a great impact on the study and analysis of dependence structures in various sciences. In multivariate analyses with dimensions of more than two variables, it is associated with computational complexities that solve vine copulas and these problems. In this study, in order to provide an approach to simulate potential evapotranspiration based on meteorological parameters in Birjand meteorological station from different family copulas including R-vine, independent R-vine, Gaussian, independent Gaussian, C-vine, C-vine independent, D-vine and D-vine independent were used. In this regard, vine copula simulation and conditional density were used. In pair correlation analysis of the studied variables using Kendall's tau statistic, dependence structure confirmed the studied parameters. The results showed a minimum correlation of −0.32 and a maximum of 0.77. The results of Akaike's information criteria (AIC), Bayesian information criteria (BIC) and LogLike statistics in evaluating the performance of vine copula dependency structure introduced the C-vine copula as the superior copula for analysing the pair dependence of the studied variables. By introducing the superior dependency structure and internal copulas, the tree sequence of the pair of values under study was obtained. Pair of simulated values was performed using vine copula. Comparison of Kendall's tau values in both simulation and observation modes showed that Kendall's tau values were close to each other in both modes and were approximately similar. The simulation results of vine copula potential evapotranspiration values and precipitation, temperature and relative humidity values showed 92% efficiency. The efficiency of C-vine copula in dependence analysis and simulation of potential evapotranspiration (PET) values is very high, which shows the ability of vine family copulas in multivariate analysis. [ABSTRACT FROM AUTHOR]

The analysis of the most common mechanisms of pragmatic focusing used by modern English-speaking authors in the reinterpretation of canonical, “roving” plots is proposed. Particular attention is paid to the context as one of the types of foregrounding, possessing ontological salience and realizing text-forming, expressive, evaluative, ludic functions. A comparative structural, compositional, and linguistic-stylistic analysis of eight literary texts intertextually correlated with the classic story of the Blue Beard made it possible to identify such methods of attention distribution in the modeled by A. Carter, D. Bartelmi, J. Updike, J. K. Oates, S. King, M. Atwood, W. Vernon, and F. Block as a ludic mode of formulating narratives, changing narrative perspectives, introducing “text within the text”, meta- fictional commentary. Along with focusing mechanisms, the article also pays attention to the defocusing of some traditional narrative elements, which is believed to be an integral part of the interpretation program of the literary texts under consideration. The authors of numerous versions of the story about Bluebeard, foregrounding various language “games of focus”, highlight the creative transformations of archetypal images and cross-cutting motives that reflect gender, socioeconomic, cultural changes in modern society.

Lesions to posterior temporo-parietal brain regions are associated with deficits in perception of global, hierarchical shapes, but also with impairments in the processing of objects presented under demanding viewing conditions. Evidence from neuroimaging studies and lesion patterns observed in patients with simultanagnosia and agnosia for object orientation suggest similar brain regions to be involved in perception of global shapes and processing of objects in atypical (‘non-canonical’) orientation. In a localizer experiment, we identified individual temporo-parietal brain areas involved in global shape perception and found significantly higher BOLD signals during the processing of non-canonical compared to canonical objects. In a multivariate approach, we demonstrated that posterior temporo-parietal brain areas show distinct voxel patterns for non-canonical and canonical objects and that voxel patterns of global shapes are more similar to those of objects in non-canonical compared to canonical viewing conditions. These results suggest that temporo-parietal brain areas are not only involved in global shape perception but might serve a more general mechanism of complex object perception. Our results challenge a strict attribution of object processing to the ventral visual stream by suggesting specific dorsal contributions in more demanding viewing conditions.