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1. Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor

Author

Boilard, Eric, Rouault, Morgane, Surrel, Fanny, Calvez, Catherine Le, Bezzine, Sofiane, Singer, Alan, Gelb, Michael H., and Lambeau, Gerard

Subjects
Binding proteins -- Structure, Membrane proteins -- Structure, Membrane proteins -- Chemical properties, Phospholipases -- Chemical properties, Biological sciences, Chemistry
Abstract

The impact of Me-Indoxam and other inhibitors on the sPLA2-receptor interaction is investigated. [Ca.sup.2+] loop mutant derived from a venom sPLA2 which is insensitive to hGIIA inhibitors but still binds to the M-type receptor, is used to demonstrate that Me-Indoxam dramatically decreases the affinity of various sPLA2S for the receptor, yet an sPLA2-Me-Indoxam-receptor complex can form at very high sPLA2 concentrations.

Published
2006

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