Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor

Authors :: Boilard, Eric
Rouault, Morgane
Surrel, Fanny
Calvez, Catherine Le
Bezzine, Sofiane
Singer, Alan
Gelb, Michael H.
Lambeau, Gerard
Source :: Biochemistry. Nov 7, 2006, Vol. 45 Issue 44, p13203, 16 p.
Publication Year :: 2006
Abstract: The impact of Me-Indoxam and other inhibitors on the sPLA2-receptor interaction is investigated. [Ca.sup.2+] loop mutant derived from a venom sPLA2 which is insensitive to hGIIA inhibitors but still binds to the M-type receptor, is used to demonstrate that Me-Indoxam dramatically decreases the affinity of various sPLA2S for the receptor, yet an sPLA2-Me-Indoxam-receptor complex can form at very high sPLA2 concentrations.

Subjects :: Binding proteins -- Structure
Membrane proteins -- Structure
Membrane proteins -- Chemical properties
Phospholipases -- Chemical properties
Biological sciences
Chemistry

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