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1. OP0001 THE EVALUATION OF SYSTEMIC SCORE IN IDENTIFYING PATIENTS WITH STILL’S DISEASE AT HIGHER RISK OF LIFE-THREATENING EVOLUTION; FINDINGS FROM GIRRCS AOSD-STUDY GROUP AND AIDA NETWORK STILL’S DISEASE REGISTRY

Author: Ruscitti, P., primary, Vitale, A., additional, Caggiano, V., additional, Cola, I. DI, additional, Sensini, F., additional, Cipriani, P., additional, Giacomelli, R., additional, and Cantarini, L., additional
Published: 2024
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2. Risk for cancer development in familial Mediterranean fever and associated predisposing factors: an ambidirectional cohort study from the international AIDA Network registries

Author: Vitale, A, Caggiano, V, Tufan, A, Ragab, G, Batu, Ed, Portincasa, P, Aragona, E, Sota, J, Conti, G, De Paulis, A, Rigante, Donato, Olivieri, An, S ̧ahin, A, La Torre, F, Lopalco, G, Cattalini, M, Maggio, Mc, Insalaco, A, Sfikakis, Pp, Verrecchia, Elena, Yildirim, D, Kucuk, H, Kardas, Rc, Laymouna, Ah, Ghanema, M, Saad, Ma, Sener, S, Ercan Emreol, H, Ozen, S, Jaber, N, Khalil, M, Di Ciaula, A, Gaggiano, C, Malizia, G, Affronti, A, Patroniti, S, Romeo, M, Sbalchiero, J, Della Casa, F, Mormile, I, Silvaroli, Sara, Gicchino, Mf, Çelik, Nç, Tarsia, M, Karamanakos, A, Hernández-Rodríguez, J, Parronchi, P, Opris-Belinski, D, Barone, P, Recke, A, Costi, S, Sfriso, P, Giardini, Ham, Gentileschi, S, Wiesik-Szewczyk, E, Vasi, I, Loconte, R, Jahnz-Różyk, K, Martín-Nares, E, Torres-Ruiz, J, Cauli, A, Conforti, A, Emmi, G, Li Gobbi, F, Biasi, Gr, Terribili, R, Ruscitti, P, Del Giudice, E, Tharwat, S, Brucato, Al, Ogunjimi, B, Hinojosa-Azaola, A, Balistreri, A, Fabiani, C, Frediani, B, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Verrecchia E, Silvaroli S, Vitale, A, Caggiano, V, Tufan, A, Ragab, G, Batu, Ed, Portincasa, P, Aragona, E, Sota, J, Conti, G, De Paulis, A, Rigante, Donato, Olivieri, An, S ̧ahin, A, La Torre, F, Lopalco, G, Cattalini, M, Maggio, Mc, Insalaco, A, Sfikakis, Pp, Verrecchia, Elena, Yildirim, D, Kucuk, H, Kardas, Rc, Laymouna, Ah, Ghanema, M, Saad, Ma, Sener, S, Ercan Emreol, H, Ozen, S, Jaber, N, Khalil, M, Di Ciaula, A, Gaggiano, C, Malizia, G, Affronti, A, Patroniti, S, Romeo, M, Sbalchiero, J, Della Casa, F, Mormile, I, Silvaroli, Sara, Gicchino, Mf, Çelik, Nç, Tarsia, M, Karamanakos, A, Hernández-Rodríguez, J, Parronchi, P, Opris-Belinski, D, Barone, P, Recke, A, Costi, S, Sfriso, P, Giardini, Ham, Gentileschi, S, Wiesik-Szewczyk, E, Vasi, I, Loconte, R, Jahnz-Różyk, K, Martín-Nares, E, Torres-Ruiz, J, Cauli, A, Conforti, A, Emmi, G, Li Gobbi, F, Biasi, Gr, Terribili, R, Ruscitti, P, Del Giudice, E, Tharwat, S, Brucato, Al, Ogunjimi, B, Hinojosa-Azaola, A, Balistreri, A, Fabiani, C, Frediani, B, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Verrecchia E, and Silvaroli S
Abstract: Objective: Inflammation has been associated with an increased risk for cancer development, while innate immune system activation could counteract the risk for malignancies. Familial Mediterranean fever (FMF) is a severe systemic inflammatory condition and also represents the archetype of innate immunity deregulation. Therefore, the aim of this study is to investigate the risk for cancer development in FMF. Methods: The risk ratio (RR) for malignancies was separately compared between FMF patients and fibromyalgia subjects, Still’s disease patients and Behçet’s disease patients. Clinical variables associated with cancer development in FMF patients were searched through binary logistic regression. Results: 580 FMF patients and 102 fibromyalgia subjects, 1012 Behçet’s disease patients and 497 Still’s disease patients were enrolled. The RR for the occurrence of malignant neoplasms was 0.26 (95% Confidence Interval [CI.] 0.10-0.73, p=0.006) in patients with FMF compared to fibromyalgia subjects; the RR for the occurrence of malignant cancer was 0.51 (95% CI. 0.23-1.16, p=0.10) in FMF compared to Still’s disease and 0.60 (95% CI. 0.29-1.28, p=0.18) in FMF compared to Behçet’s disease. At logistic regression, the risk of occurrence of malignant neoplasms in FMF patients was associated with the age at disease onset (b1 = 0.039, 95% CI. 0.001-0.071, p=0.02), the age at the diagnosis (b1 = 0.048, 95% CI. 0.039-0.085, p=0.006), the age at the enrolment (b1 = 0.05, 95% CI. 0.007-0.068, p=0.01), the number of attacks per year (b1 = 0.011, 95% CI. 0.001- 0.019, p=0.008), the use of biotechnological agents (b1 = 1.77, 95% CI. 0.43-3.19, p=0.009), the use of anti-IL-1 agents (b1 = 2.089, 95% CI. 0.7- 3.5, p=0.002). Conclusions: The risk for cancer is reduced in Caucasic FMF patients; however, when malignant neoplasms occur, this is more frequent in FMF cases suffering from a severe disease phenotype and presenting a colchicine-resistant disease.
Published: 2024

3. Preliminary data revealing efficacy of Streptococcus salivarius K12 (SSK12) in Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome: a multicenter study from the AIDA Network PFAPA syndrome registry

Author: La Torre, F, Sota, J, Insalaco, A, Conti, G, Del Giudice, E, Lubrano, R, Breda, L, Maggio, Mc, Civino, A, Mastrorilli, V, Loconte, R, Natale, Mf, Celani, C, Romeo, M, Patroniti, S, Gentile, C, Vitale, A, Caggiano, V, Gaggiano, C, Diomeda, F, Cattalini, M, Lopalco, G, Emmi, G, Parronchi, P, Gentileschi, S, Cardinale, F, Aragona, E, Shahram, F, Marino, A, Barone, P, Moscheo, C, Ozkiziltas, B, Carubbi, F, Alahmed, O, Iezzi, Ludovica, Ogunjimi, B, Mauro, A, Tarsia, M, Mahmoud, Aaa, Mayrink Giardini, Ham, Sfikakis, Pp, Laskari, K, Więsik-Szewczyk, E, Hernàndez-Rodriguez, J, Frediani, B, Gòmez-Caverzaschi, V, Tufan, A, Almaghlouth, Ia, Balistreri, A, Ragab, G, Fabiani, C, Cantarini, L, Rigante, Donato, La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, Maggio MC, Civino A, Mastrorilli V, Loconte R, Natale MF, Celani C, Romeo M, Patroniti S, Gentile C, Vitale A, Caggiano V, Gaggiano C, Diomeda F, Cattalini M, Lopalco G, Emmi G, Parronchi P, Gentileschi S, Cardinale F, Aragona E, Shahram F, Marino A, Barone P, Moscheo C, Ozkiziltas B, Carubbi F, Alahmed O, Iezzi L, Ogunjimi B, Mauro A, Tarsia M, Mahmoud AAA, Mayrink Giardini HAM, Sfikakis PP, Laskari K, Więsik-Szewczyk E, Hernàndez-Rodriguez J, Frediani B, Gòmez-Caverzaschi V, Tufan A, Almaghlouth IA, Balistreri A, Ragab G, Fabiani C, Cantarini L, Rigante D (ORCID:0000-0001-7032-7779), La Torre, F, Sota, J, Insalaco, A, Conti, G, Del Giudice, E, Lubrano, R, Breda, L, Maggio, Mc, Civino, A, Mastrorilli, V, Loconte, R, Natale, Mf, Celani, C, Romeo, M, Patroniti, S, Gentile, C, Vitale, A, Caggiano, V, Gaggiano, C, Diomeda, F, Cattalini, M, Lopalco, G, Emmi, G, Parronchi, P, Gentileschi, S, Cardinale, F, Aragona, E, Shahram, F, Marino, A, Barone, P, Moscheo, C, Ozkiziltas, B, Carubbi, F, Alahmed, O, Iezzi, Ludovica, Ogunjimi, B, Mauro, A, Tarsia, M, Mahmoud, Aaa, Mayrink Giardini, Ham, Sfikakis, Pp, Laskari, K, Więsik-Szewczyk, E, Hernàndez-Rodriguez, J, Frediani, B, Gòmez-Caverzaschi, V, Tufan, A, Almaghlouth, Ia, Balistreri, A, Ragab, G, Fabiani, C, Cantarini, L, Rigante, Donato, La Torre F, Sota J, Insalaco A, Conti G, Del Giudice E, Lubrano R, Breda L, Maggio MC, Civino A, Mastrorilli V, Loconte R, Natale MF, Celani C, Romeo M, Patroniti S, Gentile C, Vitale A, Caggiano V, Gaggiano C, Diomeda F, Cattalini M, Lopalco G, Emmi G, Parronchi P, Gentileschi S, Cardinale F, Aragona E, Shahram F, Marino A, Barone P, Moscheo C, Ozkiziltas B, Carubbi F, Alahmed O, Iezzi L, Ogunjimi B, Mauro A, Tarsia M, Mahmoud AAA, Mayrink Giardini HAM, Sfikakis PP, Laskari K, Więsik-Szewczyk E, Hernàndez-Rodriguez J, Frediani B, Gòmez-Caverzaschi V, Tufan A, Almaghlouth IA, Balistreri A, Ragab G, Fabiani C, Cantarini L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: To evaluate the potential role of Streptococcus salivarius K12 (SSK12) in controlling febrile flares in patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Further aims were to assess the impact of SSK12 on (i) flare duration, (ii) variation in the degree of the highest body temperature during flares, (iii) steroid-sparing effect, and (iv) change of PFAPA accompanying symptoms before and after SSK12 introduction. Patients and methods: The medical charts from 85 pediatric patients with PFAPA syndrome (49 males and 36 females) enrolled in the AIDA registry and treated with SSK12 for a median period of 6.00±7.00 months in the period between September 2017 and May 2022 were examined. Children recruited had a median time of disease duration of 19.00±28.00 months. Results: The number of febrile flares significantly decreased comparing the 12 months before [median (IQR), 13.00 (6.00)] and after SSK12 initiation [median (IQR), 5.50 (8.00), p<0.001]. The duration of fever was significantly reduced from 4.00 (2.00) days to 2.00 (2.00) days [p<0.001]. Similarly, the highest temperature in °C was found significantly lower in the last follow-up assessment [median (IQR), 39.00 (1.00)] compared to the period prior to SSK12 start [median (IQR), 40.00 (1.00), p<0.001]. Steroid load (mg/year) of betamethasone (or any equivalent steroid) significantly decreased between 12 months before treatment with SSK12 [median (IQR), 5.00 (8.00) mg/year] and the last follow-up visit [median (IQR), 2.00 (4.00) mg/year, p<0.001]. The number of patients experiencing symptoms including pharyngitis/tonsillitis (p<0.001), oral aphthae (p<0.001) and cervical lymphadenopathy (p<0.001) significantly decreased following SSK12. Conclusion: SSK12 prophylaxis given for at least 6.00±7.00 months was found to reduce febrile flares of PFAPA syndrome: in particular, it halved the total number per year of fever flares, shortened the
Published: 2023

4. The administration of methotrexate in patients with Still’s disease, “real-life” findings from AIDA Network Still Disease Registry

Author: 362., Ruscitti P, Sota, J, Vitale, A, Lopalco, G, Iannone, F, Morrone, M, Giardini, Ham, D'Agostin, Ma, Antonelli, Ipb, Almaghlouth, I, Asfina, Kn, Khalil, N, Sfikakis, Pp, Laskari, K, Tektonidou, M, Ciccia, F, Iacono, D, Riccio, F, Ragab, G, Hussein, Ma, Govoni, M, Ruffilli, F, Direskeneli, H, Alibaz-Oner, F, Giacomelli, R, Navarini, L, Bartoloni, E, Riccucci, I, Martín-Nares, E, Torres-Ruiz, J, Cipriani, P, Di Cola, I, Hernández-Rodríguez, J, Gómez-Caverzaschi, V, Dagna, L, Tomelleri, A, Makowska, J, Brzezinska, O, Iagnocco, A, Bellis, E, Caggiano, V, Gaggiano, C, Tarsia, M, Mormile, I, Emmi, G, Sfriso, P, Monti, S, Erten, Ş, Del Giudice, E, Lubrano, R, Conti, G, Olivieri, An, Lo Gullo, A, Tharwat, S, Karamanakos, A, Gidaro, A, Maggio, Mc, La Torre, F, Cardinale, F, Ogunjimi, B, Maier, A, Sebastiani, Gd, Opris-Belinski, D, Frassi, M, Viapiana, O, Bizzi, E, Carubbi, F, Fotis, L, Tufan, A, Kardas, Rc, Więsik-Szewczyk, E, Jahnz-Różyk, K, Fabiani, C, Frediani, B, Balistreri, A, Rigante, Donato, Cantarini, L, 362. Ruscitti P, Sota J, Vitale A, Lopalco G, Iannone F, Morrone M, Giardini HAM, D'Agostin MA, Antonelli IPB, Almaghlouth I, Asfina KN, Khalil N, Sfikakis PP, Laskari K, Tektonidou M, Ciccia F, Iacono D, Riccio F, Ragab G, Hussein MA, Govoni M, Ruffilli F, Direskeneli H, Alibaz-Oner F, Giacomelli R, Navarini L, Bartoloni E, Riccucci I, Martín-Nares E, Torres-Ruiz J, Cipriani P, Di Cola I, Hernández-Rodríguez J, Gómez-Caverzaschi V, Dagna L, Tomelleri A, Makowska J, Brzezinska O, Iagnocco A, Bellis E, Caggiano V, Gaggiano C, Tarsia M, Mormile I, Emmi G, Sfriso P, Monti S, Erten Ş, Del Giudice E, Lubrano R, Conti G, Olivieri AN, Lo Gullo A, Tharwat S, Karamanakos A, Gidaro A, Maggio MC, La Torre F, Cardinale F, Ogunjimi B, Maier A, Sebastiani GD, Opris-Belinski D, Frassi M, Viapiana O, Bizzi E, Carubbi F, Fotis L, Tufan A, Kardas RC, Więsik-Szewczyk E, Jahnz-Różyk K, Fabiani C, Frediani B, Balistreri A, Rigante D (ORCID:0000-0001-7032-7779), Cantarini L, 362., Ruscitti P, Sota, J, Vitale, A, Lopalco, G, Iannone, F, Morrone, M, Giardini, Ham, D'Agostin, Ma, Antonelli, Ipb, Almaghlouth, I, Asfina, Kn, Khalil, N, Sfikakis, Pp, Laskari, K, Tektonidou, M, Ciccia, F, Iacono, D, Riccio, F, Ragab, G, Hussein, Ma, Govoni, M, Ruffilli, F, Direskeneli, H, Alibaz-Oner, F, Giacomelli, R, Navarini, L, Bartoloni, E, Riccucci, I, Martín-Nares, E, Torres-Ruiz, J, Cipriani, P, Di Cola, I, Hernández-Rodríguez, J, Gómez-Caverzaschi, V, Dagna, L, Tomelleri, A, Makowska, J, Brzezinska, O, Iagnocco, A, Bellis, E, Caggiano, V, Gaggiano, C, Tarsia, M, Mormile, I, Emmi, G, Sfriso, P, Monti, S, Erten, Ş, Del Giudice, E, Lubrano, R, Conti, G, Olivieri, An, Lo Gullo, A, Tharwat, S, Karamanakos, A, Gidaro, A, Maggio, Mc, La Torre, F, Cardinale, F, Ogunjimi, B, Maier, A, Sebastiani, Gd, Opris-Belinski, D, Frassi, M, Viapiana, O, Bizzi, E, Carubbi, F, Fotis, L, Tufan, A, Kardas, Rc, Więsik-Szewczyk, E, Jahnz-Różyk, K, Fabiani, C, Frediani, B, Balistreri, A, Rigante, Donato, Cantarini, L, 362. Ruscitti P, Sota J, Vitale A, Lopalco G, Iannone F, Morrone M, Giardini HAM, D'Agostin MA, Antonelli IPB, Almaghlouth I, Asfina KN, Khalil N, Sfikakis PP, Laskari K, Tektonidou M, Ciccia F, Iacono D, Riccio F, Ragab G, Hussein MA, Govoni M, Ruffilli F, Direskeneli H, Alibaz-Oner F, Giacomelli R, Navarini L, Bartoloni E, Riccucci I, Martín-Nares E, Torres-Ruiz J, Cipriani P, Di Cola I, Hernández-Rodríguez J, Gómez-Caverzaschi V, Dagna L, Tomelleri A, Makowska J, Brzezinska O, Iagnocco A, Bellis E, Caggiano V, Gaggiano C, Tarsia M, Mormile I, Emmi G, Sfriso P, Monti S, Erten Ş, Del Giudice E, Lubrano R, Conti G, Olivieri AN, Lo Gullo A, Tharwat S, Karamanakos A, Gidaro A, Maggio MC, La Torre F, Cardinale F, Ogunjimi B, Maier A, Sebastiani GD, Opris-Belinski D, Frassi M, Viapiana O, Bizzi E, Carubbi F, Fotis L, Tufan A, Kardas RC, Więsik-Szewczyk E, Jahnz-Różyk K, Fabiani C, Frediani B, Balistreri A, Rigante D (ORCID:0000-0001-7032-7779), and Cantarini L
Abstract: Objectives: To describe clinical characteristics of patients with Still's disease treated with methotrexate (MTX) and to assess drug effectiveness evaluating change in disease activity, reduction of inflammatory markers, and glucocorticoid (GC)-sparing effect. Methods: Patients with Still's disease treated with MTX were assessed among those included in AIDA Network Still Disease Registry. Results: In this registry, 171 patients with Still's disease were treated with MTX (males 43.3%, age 37.1 ± 16.0 years). They were mainly characterised by joint features and fever without a prominent multiorgan involvement. MTX was administered with GCs in 68.4% of patients, with other conventional synthetic DMARDs in 6.4%, and with biologic DMARDs in 25.1%. A significant reduction of the modified systemic score was observed, and 38.6% patients were codified as being in clinical remission at the end of follow-up. The concomitant administration of a biologic DMARD resulted a predictor of the clinical remission. Furthermore, a reduction of inflammatory markers and ferritin levels was observed following the administration of MTX. Additionally, a marked reduction of the dosage of concomitant GCs was identified, while 36.7% discontinued such drugs. Male gender appeared as a predictor of GC discontinuation. MTX was discontinued in 12.3% of patients because of adverse effects, and in 12.3% for lack of efficacy. Conclusions: Clinical characteristics of patients with Still's disease treated with MTX were described, mainly joint features and fever without a prominent multiorgan involvement. The clinical usefulness of MTX was reported in reducing the disease activity, decreasing the inflammatory markers, and as GC-sparing agent.
Published: 2023

5. Factors Associated with Adherence to an End-of-Study Biopsy: Lessons from the Prostate Cancer Prevention Trial (SWOG-Coordinated Intergroup Study S9217)

Author: Gritz, E. R, Arnold, K. B, Moinpour, C. M, Burton-Chase, A. M, Tangen, C. M, Probstfield, J. F, See, W. A, Lieber, M. M, Caggiano, V., Moody-Thomas, S., Szczepanek, C., Ryan, A., Carlin, S., Hill, S., Goodman, P. J, Padberg, R. M, Minasian, L. M, Meyskens, F. L, and Thompson, I. M
Subjects: Prostate, cancer, prevention, end-of-study, biopsy
Abstract: Background: The Prostate Cancer Prevention Trial (PCPT) was a 7-year randomized, double-blind, placebocontrolled trial of the efficacy of finasteride for the prevention of prostate cancer with a primary outcome of histologically determined prevalence of prostate cancer at the end of 7 years. Methods: A systematic modeling process using logistic regression identified factors available at year 6 that are associated with end-of-study (EOS) biopsy adherence at year 7, stratified by whether participants were ever prompted for a prostate biopsy by year 6. Final models were evaluated for discrimination. At year 6,13,590 men were available for analysis. Results: Participants were more likely to have the EOS biopsy if they were adherent to study visit schedules and procedures and/or were in good health (P < 0.01). Participants at larger sites and/or sites that received retention and adherence grants were also more likely to have the EOS biopsy (P < 0.05). Conclusions: Our results show good adherence to study requirements 1 year before the EOS biopsy was associated with greater odds that a participant would comply with the invasive EOS requirement. Impact: Monitoring adherence behaviors may identify participants at risk of nonadherence to more demanding study end points. Such information could help frame adherence intervention strategies in future trials. © 2014 American Association for Cancer Research.
Published: 2014

6. The AutoInflammatory Diseases Alliance Registry of monogenic autoinflammatory diseases

Author: Gaggiano, C, Vitale, A, Tufan, A, Ragab, G, Aragona, E, Wiesik-Szewczyk, E, Ait-Idir, D, Conti, G, Iezzi, L, Maggio, Mc, Cattalini, M, La Torre, F, Lopalco, G, Verrecchia, E, de Paulis, A, Sahin, A, Insalaco, A, Sfikakis, Pp, Marino, A, Frassi, M, Ogunjimi, B, Opris-Belinski, D, Parronchi, P, Emmi, G, Shahram, F, Ciccia, F, Piga, M, Hernández-Rodríguez, J, Pereira, Rmr, Alessio, M, Naddei, R, Olivieri, An, Giudice, Ed, Sfriso, P, Ruscitti, P, Gobbi, Fl, Kucuk, H, Sota, J, Hussein, Ma, Malizia, G, Jahnz-Różyk, K, Sari-Hamidou, R, Romeo, M, Ricci, F, Cardinale, F, Iannone, F, Casa, Fd, Natale, Mf, Laskari, K, Giani, T, Franceschini, F, Sabato, V, Yildirim, D, Caggiano, V, Hegazy, Mt, Marzo, Rd, Kucharczyk, A, Khellaf, G, Tarsia, M, Almaghlouth, Ia, Laymouna, Ah, Mastrorilli, V, Dotta, L, Benacquista, L, Grosso, S, Crisafulli, F, Parretti, V, Giordano, Hf, Mahmoud, Aaa, Nuzzolese, R, Musso, M, Chighizola, Cb, Gentileschi, S, Morrone, M, Cola, Id, Spedicato, V, Giardini, Ham, Vasi, I, Renieri, A, Fabbiani, A, Mencarelli, Ma, Frediani, B, Balistreri, A, Tosi, Gm, Fabiani, C, Lidar, M, Rigante, D, Cantarini, L, Gaggiano C, Vitale A, Tufan A, Ragab G, Aragona E, Wiesik-Szewczyk E, Ait-Idir D, Iezzi L, Maggio MC, Cattalini M, La Torre F, Lopalco G, Verrecchia E, de Paulis A, Sahin A, Insalaco A, Sfikakis PP, Marino A, Frassi M, Ogunjimi B, Opris-Belinski D, Parronchi P, Emmi G, Shahram F, Ciccia F, Piga M, Hernández-Rodríguez J, Pereira RMR, Alessio M, Naddei R, Olivieri AN, Giudice ED, Sfriso P, Ruscitti P, Gobbi FL, Kucuk H, Sota J, Hussein MA, Malizia G, Jahnz-Różyk K, Sari-Hamidou R, Romeo M, Ricci F, Cardinale F, Iannone F, Casa FD, Natale MF, Laskari K, Giani T, Franceschini F, Sabato V, Yildirim D, Caggiano V, Hegazy MT, Marzo RD, Kucharczyk A, Khellaf G, Tarsia M, Almaghlouth IA, Laymouna AH, Mastrorilli V, Dotta L, Benacquista L, Grosso S, Crisafulli F, Parretti V, Giordano HF, Mahmoud AAA, Nuzzolese R, Musso M, Chighizola CB, Gentileschi S, Morrone M, Cola ID, Spedicato V, Giardini HAM, Vasi I, Renieri A, Fabbiani A, Mencarelli MA, Frediani B, Balistreri A, Tosi GM, Fabiani C, Lidar M, Rigante D (ORCID:0000-0001-7032-7779), Cantarini L, Conti G, Gaggiano, C, Vitale, A, Tufan, A, Ragab, G, Aragona, E, Wiesik-Szewczyk, E, Ait-Idir, D, Conti, G, Iezzi, L, Maggio, Mc, Cattalini, M, La Torre, F, Lopalco, G, Verrecchia, E, de Paulis, A, Sahin, A, Insalaco, A, Sfikakis, Pp, Marino, A, Frassi, M, Ogunjimi, B, Opris-Belinski, D, Parronchi, P, Emmi, G, Shahram, F, Ciccia, F, Piga, M, Hernández-Rodríguez, J, Pereira, Rmr, Alessio, M, Naddei, R, Olivieri, An, Giudice, Ed, Sfriso, P, Ruscitti, P, Gobbi, Fl, Kucuk, H, Sota, J, Hussein, Ma, Malizia, G, Jahnz-Różyk, K, Sari-Hamidou, R, Romeo, M, Ricci, F, Cardinale, F, Iannone, F, Casa, Fd, Natale, Mf, Laskari, K, Giani, T, Franceschini, F, Sabato, V, Yildirim, D, Caggiano, V, Hegazy, Mt, Marzo, Rd, Kucharczyk, A, Khellaf, G, Tarsia, M, Almaghlouth, Ia, Laymouna, Ah, Mastrorilli, V, Dotta, L, Benacquista, L, Grosso, S, Crisafulli, F, Parretti, V, Giordano, Hf, Mahmoud, Aaa, Nuzzolese, R, Musso, M, Chighizola, Cb, Gentileschi, S, Morrone, M, Cola, Id, Spedicato, V, Giardini, Ham, Vasi, I, Renieri, A, Fabbiani, A, Mencarelli, Ma, Frediani, B, Balistreri, A, Tosi, Gm, Fabiani, C, Lidar, M, Rigante, D, Cantarini, L, Gaggiano C, Vitale A, Tufan A, Ragab G, Aragona E, Wiesik-Szewczyk E, Ait-Idir D, Iezzi L, Maggio MC, Cattalini M, La Torre F, Lopalco G, Verrecchia E, de Paulis A, Sahin A, Insalaco A, Sfikakis PP, Marino A, Frassi M, Ogunjimi B, Opris-Belinski D, Parronchi P, Emmi G, Shahram F, Ciccia F, Piga M, Hernández-Rodríguez J, Pereira RMR, Alessio M, Naddei R, Olivieri AN, Giudice ED, Sfriso P, Ruscitti P, Gobbi FL, Kucuk H, Sota J, Hussein MA, Malizia G, Jahnz-Różyk K, Sari-Hamidou R, Romeo M, Ricci F, Cardinale F, Iannone F, Casa FD, Natale MF, Laskari K, Giani T, Franceschini F, Sabato V, Yildirim D, Caggiano V, Hegazy MT, Marzo RD, Kucharczyk A, Khellaf G, Tarsia M, Almaghlouth IA, Laymouna AH, Mastrorilli V, Dotta L, Benacquista L, Grosso S, Crisafulli F, Parretti V, Giordano HF, Mahmoud AAA, Nuzzolese R, Musso M, Chighizola CB, Gentileschi S, Morrone M, Cola ID, Spedicato V, Giardini HAM, Vasi I, Renieri A, Fabbiani A, Mencarelli MA, Frediani B, Balistreri A, Tosi GM, Fabiani C, Lidar M, Rigante D (ORCID:0000-0001-7032-7779), Cantarini L, and Conti G
Abstract: Objective: The present manuscript aims to describe an international, electronic-based, user-friendly and interoperable patient registry for monogenic autoinflammatory diseases (mAIDs), developed in the contest of the Autoinflammatory Diseases Alliance (AIDA) Network. Methods: This is an electronic platform, based on the Research Electronic Data Capture (REDCap) tool, used for real-world data collection of demographics, clinical, laboratory, instrumental and socioeconomic data of mAIDs patients. The instrument has flexibility, may change over time based on new scientific acquisitions, and communicate potentially with other similar registries; security, data quality and data governance are corner stones of the platform. Results: AIDA project will share knowledge and expertise on mAIDs. Since its start, 118 centers from 24 countries and 4 continents have joined the AIDA project. Fifty-nine centers have already obtained the approval from their local Ethics Committees. Currently, the platform counts 337 users (122 Principal Investigators, 210 Site Investigators, 2 Lead Investigators, and 3 data managers). The Registry collects baseline and follow-up data using 3,748 fields organized into 21 instruments, which include demographics, patient history, symptoms, trigger/risk factors, therapies, and healthcare information for mAIDs patients. Conclusions: The AIDA mAIDs Registry, acts both as a research tool for future collaborative real-life studies on mAIDs and as a service to connect all the figures called to participate. On this basis, the registry is expected to play a pivotal role in generating new scientific evidence on this group of rare diseases, substantially improving the management of patients, and optimizing the impact on the healthcare system. NCT 05200715 available at https://clinicaltrials.gov
Published: 2022

7. POS0756 EFFICACY AND SAFETY OF ADALIMUMAB IN PEDIATRIC NON-INFECTIOUS NON-ANTERIOR UVEITIS: REAL-LIFE EXPERIENCE FROM AIDA INTERNATIONAL REGISTRY

Author: Fabiani, C., primary, Vitale, A., additional, Della Casa, F., additional, Guerriero, S., additional, Ragab, G., additional, Brucato, A., additional, Cattalini, M., additional, Del Giudice, E., additional, Marino, A., additional, Paroli, M. P., additional, Gaggiano, C., additional, Sota, J., additional, Caggiano, V., additional, Tarsia, M., additional, Frediani, B., additional, and Cantarini, L., additional
Published: 2023
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8. AB0431 CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL’S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONIC-ARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY

Author: Vitale, A., primary, Caggiano, V., additional, Maggio, M. C., additional, Lopalco, G., additional, Emmi, G., additional, Sota, J., additional, La Torre, F., additional, Ruscitti, P., additional, Bartoloni, E., additional, Conti, G., additional, Fabiani, C., additional, Mattioli, I., additional, Gaggiano, C., additional, Cardinale, F., additional, Dagna, L., additional, Campochiaro, C., additional, Giacomelli, R., additional, Balistreri, A., additional, Laskari, K., additional, Tufan, A., additional, Ragab, G., additional, Almaghlouth, I., additional, Więsik-Szewczyk, E., additional, Pereira, R. M., additional, Frediani, B., additional, Iannone, F., additional, Sfikakis, P., additional, and Cantarini, L., additional
Published: 2023
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9. Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoinflammatory diseases (USAIDs)

Author: Vitale, A, Caggiano, V, Silva, I, Oliveira, Dg, Ruscitti, P, Ciccia, F, Vasi, I, Tufan, A, Lopalco, G, Almaghlouth, Ia, Sota, J, Wiesik-Szewczyk, E, Gaggiano, C, Giardini, Ham, Spedicato, V, Ragab, G, Iannone, F, Balistreri, A, Frassi, M, Hernández-Rodríguez, J, Fabiani, C, Falsetti, P, Di Meglio, N, Frediani, B, Mazzei, Ma, Rigante, Donato, Faria, R, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Vitale, A, Caggiano, V, Silva, I, Oliveira, Dg, Ruscitti, P, Ciccia, F, Vasi, I, Tufan, A, Lopalco, G, Almaghlouth, Ia, Sota, J, Wiesik-Szewczyk, E, Gaggiano, C, Giardini, Ham, Spedicato, V, Ragab, G, Iannone, F, Balistreri, A, Frassi, M, Hernández-Rodríguez, J, Fabiani, C, Falsetti, P, Di Meglio, N, Frediani, B, Mazzei, Ma, Rigante, Donato, Faria, R, Cantarini, L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Background: Despite the recent advances in the field of autoinflammatory diseases, most patients with recurrent fever episodes do not have any defined diagnosis. The present study aims at describing a cohort of patients suffering from apparently unexplained recurrent fever, in whom non-radiographic axial spondylarthritis (SpA) represented the unique diagnosis identified after a complete clinical and radiologic assessment. Materials and methods: Patients' data were obtained from the international registry on Undifferentiated Systemic AutoInflammatory Diseases (USAIDs) developed by the AutoInflammatory Disease Alliance (AIDA) network. Results: A total of 54 patients with recurrent fever episodes were also affected by non-radiographic axial SpA according to the international classification criteria. SpA was diagnosed after the start of fever episodes in all cases; the mean age at the diagnosis of axial SpA was 39.9 ± 14.8 years with a diagnostic delay of 9.3 years. The highest body temperature reached during flares was 42°C, with a mean temperature of 38.8 ± 1.1°C. The most frequent manifestations associated to fever were: arthralgia in 33 (61.1%) cases, myalgia in 24 (44.4%) cases, arthritis in 22 (40.7%) cases, headache in 15 (27.8%) cases, diarrhea in 14 (25.9%) cases, abdominal pain in 13 (24.1%) cases, and skin rash in 12 (22.1%) cases. Twenty-four (44.4%) patients have taken daily or on-demand non-steroidal anti-inflammatory drugs (NSAIDs) and 31 (57.4%) patients have been treated with daily or on demand oral glucocorticoids. Colchicine was used in 28 (51.8%) patients, while other conventional disease modifying anti-rheumatic drugs (cDMARDs) were employed in 28 (51.8%) patients. Forty (74.1%) patients underwent anti-tumor necrosis factor (TNF) agents and 11 (20.4%) were treated with interleukin (IL)-1 inhibitors. The response to TNF inhibitors on recurrent fever episodes appeared more effective than that observed with anti-IL-1 agents; colchicine and other cDMARD
Published: 2023

10. A patient-driven registry on Behçet's disease: the AIDA for patients pilot project

Author: Gaggiano, C, Del Bianco, A, Sota, J, Gentileschi, S, Ruscitti, P, Giacomelli, R, Piga, M, Crisafulli, F, Monti, S, Emmi, G, De Paulis, A, Vitale, A, Tarsia, M, Caggiano, V, Nuzzolese, R, Parretti, V, Fabiani, C, Lopalco, G, Maier, A, Cattalini, M, Rigante, Donato, Govoni, M, Li Gobbi, F, Guiducci, S, Parronchi, P, Marino, A, Ciccia, F, Maggio, Mc, Aragona, E, Bartoloni, E, Iagnocco, A, Viapiana, O, Sebastiani, Gd, Guerriero, S, Insalaco, A, Del Giudice, E, Conti, G, Barone, P, Olivieri, An, Brucato, A, Carubbi, F, Triggianese, P, Mauro, A, Tosi, Gm, Fonollosa, A, Giardini, Ham, Ragab, G, Tharwat, S, Hernández-Rodríguez, J, Sfikakis, Pp, Laskari, K, Karamanakos, A, Espinosa, G, Shahram, F, Direskeneli, H, Hinojosa-Azaola, A, Opris-Belinski, D, Almaghlouth, Ia, Hatemi, G, Eksin, Ma, Önen, F, Więsik-Szewczyk, E, Akkoç, N, Tufan, A, Şahin, A, Erten, Ş, Ozen, S, Batu, Ed, Frediani, B, Balistreri, A, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Gaggiano, C, Del Bianco, A, Sota, J, Gentileschi, S, Ruscitti, P, Giacomelli, R, Piga, M, Crisafulli, F, Monti, S, Emmi, G, De Paulis, A, Vitale, A, Tarsia, M, Caggiano, V, Nuzzolese, R, Parretti, V, Fabiani, C, Lopalco, G, Maier, A, Cattalini, M, Rigante, Donato, Govoni, M, Li Gobbi, F, Guiducci, S, Parronchi, P, Marino, A, Ciccia, F, Maggio, Mc, Aragona, E, Bartoloni, E, Iagnocco, A, Viapiana, O, Sebastiani, Gd, Guerriero, S, Insalaco, A, Del Giudice, E, Conti, G, Barone, P, Olivieri, An, Brucato, A, Carubbi, F, Triggianese, P, Mauro, A, Tosi, Gm, Fonollosa, A, Giardini, Ham, Ragab, G, Tharwat, S, Hernández-Rodríguez, J, Sfikakis, Pp, Laskari, K, Karamanakos, A, Espinosa, G, Shahram, F, Direskeneli, H, Hinojosa-Azaola, A, Opris-Belinski, D, Almaghlouth, Ia, Hatemi, G, Eksin, Ma, Önen, F, Więsik-Szewczyk, E, Akkoç, N, Tufan, A, Şahin, A, Erten, Ş, Ozen, S, Batu, Ed, Frediani, B, Balistreri, A, Cantarini, L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Introduction: This paper describes the creation and preliminary results of a patient-driven registry for the collection of patient-reported outcomes (PROs) and patient-reported experiences (PREs) in Behçet’s disease (BD). Methods: The project was coordinated by the University of Siena and the Italian patient advocacy organization SIMBA (Associazione Italiana Sindrome e Malattia di Behçet), in the context of the AIDA (AutoInflammatory Diseases Alliance) Network programme. Quality of life, fatigue, socioeconomic impact of the disease and therapeutic adherence were selected as core domains to include in the registry. Results: Respondents were reached via SIMBA communication channels in 167 cases (83.5%) and the AIDA Network affiliated clinical centers in 33 cases (16.5%). The median value of the Behçet’s Disease Quality of Life (BDQoL) score was 14 (IQR 11, range 0–30), indicating a medium quality of life, and the median Global Fatigue Index (GFI) was 38.7 (IQR 10.9, range 1–50), expressing a significant level of fatigue. The mean Beliefs about Medicines Questionnaire (BMQ) necessity-concern differential was 0.9 ± 1.1 (range – 1.8–4), showing that the registry participants prioritized necessity belief over concerns to a limited extent. As for the socioeconomic impact of BD, in 104 out of 187 cases (55.6%), patients had to pay from their own pocket for medical exams required to reach the diagnosis. The low family socioeconomic status (p < 0.001), the presence of any major organ involvement (p < 0.031), the presence of gastro-intestinal (p < 0.001), neurological (p = 0.012) and musculoskeletal (p = 0.022) symptoms, recurrent fever (p = 0.002), and headache (p < 0.001) were associated to a higher number of accesses to the healthcare system. Multiple linear regression showed that the BDQoL score could significantly predict the global socioeconomic impact of BD (F = 14.519, OR 1.162 [CI 0.557–1.766], p < 0.001). Discussion: Preliminary results from the AID
Published: 2023

11. Musculoskeletal manifestations in children with Behçet's syndrome: data from the AIDA Network Behçet's Syndrome Registry

Author: Gaggiano, C, Maselli, A, Sfikakis, Pp, Laskari, K, Ragab, G, Hegazy, Mt, Laymouna, Ah, Lopalco, G, Almaghlouth, Ia, Asfina, Kn, Alahmed, O, Giardini Mayrink, Ha, Parente de Brito Antonelli, I, Cattalini, M, Piga, M, Sota, J, Gentileschi, S, Maggio, Mc, Opris-Belinski, D, Hatemi, G, Insalaco, A, Olivieri, An, Tufan, A, Karadeniz, H, Kardaş, Rc, La Torre, F, Cardinale, F, Marino, A, Guerriero, S, Ruscitti, P, Tarsia, M, Vitale, A, Caggiano, V, Telesca, S, Iannone, F, Parretti, V, Frassi, M, Aragona, E, Ciccia, F, Wiesik-Szewczyk, E, Ionescu, R, Şahin, A, Akkoç, N, Hinojosa-Azaola, A, Tharwat, S, Hernández-Rodríguez, J, Espinosa, G, Conti, G, Del Giudice, E, Govoni, M, Emmi, G, Fabiani, C, Balistreri, A, Frediani, B, Rigante, Donato, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Gaggiano, C, Maselli, A, Sfikakis, Pp, Laskari, K, Ragab, G, Hegazy, Mt, Laymouna, Ah, Lopalco, G, Almaghlouth, Ia, Asfina, Kn, Alahmed, O, Giardini Mayrink, Ha, Parente de Brito Antonelli, I, Cattalini, M, Piga, M, Sota, J, Gentileschi, S, Maggio, Mc, Opris-Belinski, D, Hatemi, G, Insalaco, A, Olivieri, An, Tufan, A, Karadeniz, H, Kardaş, Rc, La Torre, F, Cardinale, F, Marino, A, Guerriero, S, Ruscitti, P, Tarsia, M, Vitale, A, Caggiano, V, Telesca, S, Iannone, F, Parretti, V, Frassi, M, Aragona, E, Ciccia, F, Wiesik-Szewczyk, E, Ionescu, R, Şahin, A, Akkoç, N, Hinojosa-Azaola, A, Tharwat, S, Hernández-Rodríguez, J, Espinosa, G, Conti, G, Del Giudice, E, Govoni, M, Emmi, G, Fabiani, C, Balistreri, A, Frediani, B, Rigante, Donato, Cantarini, L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: This study aims to describe musculoskeletal manifestations (MSM) in children with Behçet’s syndrome (BS), their association with other disease manifestations, response to therapy, and long-term prognosis. Data were retrieved from the AIDA Network Behçet’s Syndrome Registry. Out of a total of 141 patients with juvenile BS, 37 had MSM at disease onset (26.2%). The median age at onset was 10.0 years (IQR 7.7). The median follow-up duration was 21.8 years (IQR 23.3). Recurrent oral (100%) and genital ulcers (67.6%) and pseudofolliculitis (56.8%) were the most common symptoms associated with MSM. At disease onset, 31 subjects had arthritis (83.8%), 33 arthralgia (89.2%), and 14 myalgia (37.8%). Arthritis was monoarticular in 9/31 cases (29%), oligoarticular in 10 (32.3%), polyarticular in 5 (16.1%), axial in 7 (22.6%). Over time, arthritis became chronic-recurrent in 67.7% of cases and 7/31 patients had joint erosions (22.6%). The median Behçet's Syndrome Overall Damage Index was 0 (range 0–4). Colchicine was inefcacious for MSM in 4/14 cases (28.6%), independently from the type of MSM (p=0.46) or the concomitant therapy (p=0.30 for cDMARDs, p=1.00 for glucocorticoids); cDMARDs and bDMARDs were inefcacious for MSM in 6/19 (31.4%) and 5/12 (41.7%) cases. The presence of myalgia was associated with bDMARDs inefcacy (p=0.014). To conclude, MSM in children with BS are frequently associated with recurrent ulcers and pseudofolliculitis. Arthritis is mostly mono- or oligoarticular, but sacroiliitis is not unusual. Prognosis of this subset of BS is overall favorable, though the presence of myalgia negatively afects response to biologic therapies.
Published: 2023

12. Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry

Author: Vitale, A., Casa, F. D., Guerriero, S., Ragab, G., Mauro, A., Caggiano, V., Cattalini, M., Del Giudice, E., Favale, R., Gaggiano, C., Bellicini, I., Paroli, M. P., Hegazy, M. T., Sota, J., Tufan, A., Balistreri, A., Almaghlouth, I., La Torre, F., Więsik-Szewczyk, E., Tarsia, M., Hinojosa-Azaola, A., Martín-Nares, E., Frediani, B., Tosi, G. M., Fonollosa, A., Hernández-Rodríguez, J., Amin, R. H., Lopalco, G., Rigante, Donato, Cantarini, L., Fabiani, C., Rigante D. (ORCID:0000-0001-7032-7779), Vitale, A., Casa, F. D., Guerriero, S., Ragab, G., Mauro, A., Caggiano, V., Cattalini, M., Del Giudice, E., Favale, R., Gaggiano, C., Bellicini, I., Paroli, M. P., Hegazy, M. T., Sota, J., Tufan, A., Balistreri, A., Almaghlouth, I., La Torre, F., Więsik-Szewczyk, E., Tarsia, M., Hinojosa-Azaola, A., Martín-Nares, E., Frediani, B., Tosi, G. M., Fonollosa, A., Hernández-Rodríguez, J., Amin, R. H., Lopalco, G., Rigante, Donato, Cantarini, L., Fabiani, C., and Rigante D. (ORCID:0000-0001-7032-7779)
Abstract: Introduction: Scientific evidence of the effectiveness of the tumor necrosis factor inhibitor adalimumab (ADA) in pediatric patients with non-infectious non-anterior uveitis is still limited. The aim of this study is to investigate the therapeutic role of ADA in a cohort of pediatric patients with non-anterior uveitis. MethodsThis is an international multicenter study analyzing real-life data referred to pediatric patients treated with ADA for intermediate uveitis/pars planitis, posterior uveitis and panuveitis. Data were drawn from the AutoInflammatory Disease Alliance (AIDA) registry for patients with uveitis. ResultsTwenty-one patients (36 affected eyes) were enrolled, and all patients benefited from ADA administration. In detail, 11 patients (19 affected eyes) did not experience further ocular inflammation after ADA introduction; 10 cases (17 affected eyes) showed a significant clinical improvement consisting of a decrease in severity and/or frequency of ocular relapses. The number of ocular flares dropped from 3.91 to 1.1 events/patient/year after ADA introduction (p = 0.0009); macular edema and retinal vasculitis were respectively observed in 18 eyes and 20 eyes at the start of ADA and in 4 eyes and 2 eyes at the last assessment. The mean daily glucocorticoid dosage significantly decreased from 26.8 +/- 16.8 mg/day at the start of ADA to 6.25 +/- 6.35 mg/day at the last assessment (p = 0.002). Intermediate uveitis/pars planitis (p = 0.01) and posterior uveitis (p = 0.03) were more frequently observed in patients with full response to ADA; panuveitis (p = 0.001) was significantly more frequent among patients continuing to experience uveitic flares. This could be related to a higher use of systemic glucocorticoids (p = 0.002) and conventional immunosuppressants (p = 0.007) at the start of ADA when treating intermediate uveitis/pars planitis. Regarding the safety profile, only one adverse event was reported during ADA treatment, consisting of the development of g
Published: 2023

13. Soft Skills In University Teachers: A Cross-Sectional Study

Author: valeria Caggiano, Ragusa A., Caggiano V., Trigueros Ramos, R. González-Bernal, J. J. Gentil-Gutiérrez, A. Bastos, S. A. M. C., Santamaría-Peláez, M, Caggiano, Valeria, Ragusa, A., Caggiano, V., Trigueros, Ramo, González-Bernal, R., Gentil-Gutiérrez, J. J., Bastos, A., amp, S. A. M. C., and Santamaría-Peláez, M
Subjects: European education system, soft skill, cultural value, teaching competence [Keywords]
Abstract: In the era of globalization and technology, society demands young generations of citizens able to work in a kind of environment characterized by complexity and diversity. Therefore, the education system faces a new kind of challenge, as graduates are reported to need transversal skills, which are unlikely to be learned through traditional classroom teaching. The overall aim of this article is to examine the needs for these skills and their acquisition by higher education teachers to cope with the evolving European labour market of the 2020s. The article envisions the importance of soft skills in the teaching profession. The empirical part consists of a comparative study with Italian and Portuguese teachers, highlighting the status of a set of crucial soft skills (assertiveness, networking skills, teamwork, sensitivity, socialization, action-orientation, ability to work under pressure and social desirability)
Published: 2022

14. Probabilistic Detection and Tracking of Faces in Video

Author: Boccignone, G., Caggiano, V., Di Fiore, G., Marcelli, A., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Roli, Fabio, editor, and Vitulano, Sergio, editor
Published: 2005
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15. Development and implementation of the AIDA International Registry for patients with undifferentiated systemic autoinflammatory diseases

Author: Della Casa, F, Vitale, A, Lopalco, G, Ruscitti, P, Ciccia, F, Emmi, G, Cattalini, M, Wiesik-Szewczyk, E, Maggio, Mc, Ogunjimi, B, Sfikakis, Pp, Tufan, A, Al-Mayouf, Sm, Del Giudice, E, Aragona, E, La Torre, F, Sota, J, Colella, S, Di Cola, I, Iacono, D, Mattioli, I, Jahnz-Rózyk, K, Joos, R, Laskari, K, Gaggiano, C, Abbruzzese, A, Cipriani, P, Rozza, G, Alsaleem, A, Yildirim, D, Tarsia, M, Ragab, G, Ricci, F, Cardinale, F, Korzeniowska, M, Frassi, M, Caggiano, V, Saad, Ma, Pereira, Rm, Berlengiero, V, Gentileschi, S, Guerriero, S, Giani, T, Gelardi, V, Iannone, F, Giardini, Ham, Almaghlouth, Ia, Kardas, Rc, Ait-Idir, D, Frediani, B, Balistreri, A, Fabiani, C, Rigante, Donato, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Della Casa, F, Vitale, A, Lopalco, G, Ruscitti, P, Ciccia, F, Emmi, G, Cattalini, M, Wiesik-Szewczyk, E, Maggio, Mc, Ogunjimi, B, Sfikakis, Pp, Tufan, A, Al-Mayouf, Sm, Del Giudice, E, Aragona, E, La Torre, F, Sota, J, Colella, S, Di Cola, I, Iacono, D, Mattioli, I, Jahnz-Rózyk, K, Joos, R, Laskari, K, Gaggiano, C, Abbruzzese, A, Cipriani, P, Rozza, G, Alsaleem, A, Yildirim, D, Tarsia, M, Ragab, G, Ricci, F, Cardinale, F, Korzeniowska, M, Frassi, M, Caggiano, V, Saad, Ma, Pereira, Rm, Berlengiero, V, Gentileschi, S, Guerriero, S, Giani, T, Gelardi, V, Iannone, F, Giardini, Ham, Almaghlouth, Ia, Kardas, Rc, Ait-Idir, D, Frediani, B, Balistreri, A, Fabiani, C, Rigante, Donato, Cantarini, L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: This paper points out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients affected with Undifferentiated Systemic AutoInflammatory Diseases (USAIDs). Methods: This is a physician-driven, population- and electronic-based registry employed for real-world data collection about demographics, clinical, laboratory, instrumental and socioeconomic data of USAIDs patients. Data recruitment, based on the Research Electronic Data Capture (REDCap) tool, is thought to gain standardised information for real-life research and has been developed to change over time according to the scientific acquisitions and potentially communicate with other similar instruments; this platform ensures security, data quality and data governance. Results: The focus of the AIDA project is connecting physicians and researchers from all over the world to shed a new light on heterogeneous rare diseases. Since its birth, 99 centres from 20 countries and 4 continents have joined the AIDA project. Forty-eight centres have already obtained the approval from their local Ethics Committees. Currently, the platform counts 265 users (99 Principal Investigators, 162 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry is collecting baseline and follow-up data using 3357 fields organised into 23 instruments, which include demographics, history, symptoms, trigger/risk factors, therapies, and healthcare access for USAIDs patients. Conclusions: The development of the AIDA International Registry for USAIDs patients will facilitate the on-line collection of standardised data, connecting a worldwide group of researchers: the Registry constitutes an international multicentre observational groundwork aimed at increasing the study cohort of patients with USAIDs in order to improve our knowledge of this peculiar cluster of autoinflammatory diseases.
Published: 2022

16. Development and implementation of the AIDA International Registry for patients with Behçet's disease

Author: Vitale, A, Della Casa, F, Ragab, G, Almaghlouth, Ia, Lopalco, G, Pereira, Rm, Guerriero, S, Govoni, M, Sfikakis, Pp, Giacomelli, R, Ciccia, F, Monti, S, Ruscitti, P, Piga, M, Lomater, C, Tufan, A, Opris-Belinski, D, Emmi, G, Hernández-Rodríguez, J, Şahin, A, Sebastiani, Gd, Bartoloni, E, Akkoç, N, Gündüz, Ö, Cattalini, M, Conti, Giorgio, Hatemi, G, Maier, A, Parronchi, P, Del Giudice, E, Erten, S, Insalaco, A, Li Gobbi, F, Maggio, Mc, Shahram, F, Caggiano, V, Hegazy, Mt, Asfina, Kn, Morrone, M, Prado, Ll, Dammacco, R, Ruffilli, F, Arida, A, Navarini, L, Pantano, I, Cavagna, L, Conforti, A, Cauli, A, Marucco, Em, Kucuk, H, Ionescu, R, Mattioli, I, Espinosa, G, Araújo, O, Karkaş, B, Canofari, C, Sota, J, Laymouna, Ah, Bedaiwi, Aa, Colella, S, Giardini, Ham, Albano, V, Lo Monaco, A, Fragoulis, Ge, Kardas, Rc, Berlengiero, V, Hussein, Ma, Ricci, F, La Torre, F, Rigante, Donato, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Tosi, Gm, Dagostin, Ma, Mahmoud, Aaa, Tarsia, M, Alessio, G, Cimaz, R, Giani, T, Gaggiano, C, Iannone, F, Cipriani, P, Mourabi, M, Spedicato, V, Barneschi, S, Aragona, E, Balistreri, A, Frediani, B, Fabiani, C, Cantarini, L &amp, Autoinflammatory Diseases Alliance (AIDA), Network, Conti G (ORCID:0000-0002-8566-9365), Rigante D (ORCID:0000-0001-7032-7779), Vitale, A, Della Casa, F, Ragab, G, Almaghlouth, Ia, Lopalco, G, Pereira, Rm, Guerriero, S, Govoni, M, Sfikakis, Pp, Giacomelli, R, Ciccia, F, Monti, S, Ruscitti, P, Piga, M, Lomater, C, Tufan, A, Opris-Belinski, D, Emmi, G, Hernández-Rodríguez, J, Şahin, A, Sebastiani, Gd, Bartoloni, E, Akkoç, N, Gündüz, Ö, Cattalini, M, Conti, Giorgio, Hatemi, G, Maier, A, Parronchi, P, Del Giudice, E, Erten, S, Insalaco, A, Li Gobbi, F, Maggio, Mc, Shahram, F, Caggiano, V, Hegazy, Mt, Asfina, Kn, Morrone, M, Prado, Ll, Dammacco, R, Ruffilli, F, Arida, A, Navarini, L, Pantano, I, Cavagna, L, Conforti, A, Cauli, A, Marucco, Em, Kucuk, H, Ionescu, R, Mattioli, I, Espinosa, G, Araújo, O, Karkaş, B, Canofari, C, Sota, J, Laymouna, Ah, Bedaiwi, Aa, Colella, S, Giardini, Ham, Albano, V, Lo Monaco, A, Fragoulis, Ge, Kardas, Rc, Berlengiero, V, Hussein, Ma, Ricci, F, La Torre, F, Rigante, Donato, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Tosi, Gm, Dagostin, Ma, Mahmoud, Aaa, Tarsia, M, Alessio, G, Cimaz, R, Giani, T, Gaggiano, C, Iannone, F, Cipriani, P, Mourabi, M, Spedicato, V, Barneschi, S, Aragona, E, Balistreri, A, Frediani, B, Fabiani, C, Cantarini, L &amp, Autoinflammatory Diseases Alliance (AIDA), Network, Conti G (ORCID:0000-0002-8566-9365), and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: Purpose of the present paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to pediatric and adult patients with Behçet’s disease (BD). Methods: The Registry is a clinical physician-driven population- and electronic-based instrument implemented for the retrospective and prospective collection of real-life data about demographics, clinical, therapeutic, laboratory, instrumental and socioeconomic information from BD patients; the Registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical real-life research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing and future Registries dedicated to BD. Results: Starting from January 31st to November 23rd, 2021, 99 centres from 20 countries in 4 continents have been involved. Forty-eight of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 265 users (99 Principal Investigators, 162 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 5474 fields organised into 15 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: The development of the AIDA International Registry for BD patients will facilitate the collection of standardised data leading to real-world evidence, enabling international multicentre collaborative research through data sharing, international consultation, dissemination of knowledge, inclusion of patients and families, and ultimately optimisation of scientific efforts and implementation of standardised care.
Published: 2022

17. Development and implementation of the AIDA International Registry for patients with VEXAS syndrome

Author: Vitale, A, Caggiano, V, Della Casa, F, Hernández-Rodríguez, J, Frassi, M, Monti, S, Tufan, A, Telesca, S, Conticini, E, Ragab, G, Lopalco, G, Almaghlouth, I, Pereira, Rmr, Yildirim, D, Cattalini, M, Marino, A, Giani, T, La Torre, F, Ruscitti, P, Aragona, E, Wiesik-Szewczyk, E, Del Giudice, E, Sfikakis, Pp, Govoni, M, Emmi, G, Maggio, Mc, Giacomelli, R, Ciccia, F, Conti, Giorgio, Ait-Idir, D, Lomater, C, Sabato, V, Piga, M, Sahin, A, Opris-Belinski, D, Ionescu, R, Bartoloni, E, Franceschini, F, Parronchi, P, de Paulis, A, Espinosa, G, Maier, A, Sebastiani, Gd, Insalaco, A, Shahram, F, Sfriso, P, Minoia, F, Alessio, M, Makowska, J, Hatemi, G, Akkoç, N, Li Gobbi, F, Gidaro, A, Olivieri, An, Al-Mayouf, Sm, Erten, S, Gentileschi, S, Vasi, I, Tarsia, M, Mahmoud, Aaa, Frediani, B, Fares Alzahrani, M, Laymouna, Ah, Ricci, F, Cardinale, F, Jahnz-Rózyk, K, Tosi, Gm, Crisafulli, F, Balistreri, A, Dagostin, Ma, Ghanema, M, Gaggiano, C, Sota, J, Di Cola, I, Fabiani, C, Giardini, Ham, Renieri, A, Fabbiani, A, Carrer, A, Bocchia, M, Caroni, F, Rigante, Donato, Cantarini, L, Conti G (ORCID:0000-0002-8566-9365), Rigante D (ORCID:0000-0001-7032-7779), Vitale, A, Caggiano, V, Della Casa, F, Hernández-Rodríguez, J, Frassi, M, Monti, S, Tufan, A, Telesca, S, Conticini, E, Ragab, G, Lopalco, G, Almaghlouth, I, Pereira, Rmr, Yildirim, D, Cattalini, M, Marino, A, Giani, T, La Torre, F, Ruscitti, P, Aragona, E, Wiesik-Szewczyk, E, Del Giudice, E, Sfikakis, Pp, Govoni, M, Emmi, G, Maggio, Mc, Giacomelli, R, Ciccia, F, Conti, Giorgio, Ait-Idir, D, Lomater, C, Sabato, V, Piga, M, Sahin, A, Opris-Belinski, D, Ionescu, R, Bartoloni, E, Franceschini, F, Parronchi, P, de Paulis, A, Espinosa, G, Maier, A, Sebastiani, Gd, Insalaco, A, Shahram, F, Sfriso, P, Minoia, F, Alessio, M, Makowska, J, Hatemi, G, Akkoç, N, Li Gobbi, F, Gidaro, A, Olivieri, An, Al-Mayouf, Sm, Erten, S, Gentileschi, S, Vasi, I, Tarsia, M, Mahmoud, Aaa, Frediani, B, Fares Alzahrani, M, Laymouna, Ah, Ricci, F, Cardinale, F, Jahnz-Rózyk, K, Tosi, Gm, Crisafulli, F, Balistreri, A, Dagostin, Ma, Ghanema, M, Gaggiano, C, Sota, J, Di Cola, I, Fabiani, C, Giardini, Ham, Renieri, A, Fabbiani, A, Carrer, A, Bocchia, M, Caroni, F, Rigante, Donato, Cantarini, L, Conti G (ORCID:0000-0002-8566-9365), and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities of dissemination. Methods: The present registry is a clinical, physician-driven, population- and electronic-based instrument designed for the retrospective and prospective collection of real-life data. Data gathering is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain real-world evidence for daily patients’ management; the registry may potentially communicate with other on-line tools dedicated to VEXAS syndrome, enhancing international collaboration and data sharing for research purposes. The registry is handy enough to be easily modified to meet future needs regarding VEXAS syndrome. Results: To date (April 2022), 105 Centers from 23 Countries in 4 continents have been involved; 287 users (106 Principal Investigators, 177 Site Investigators, 2 Lead Investigators, and 2 data managers) may already enter the registry for data collection and sharing. The registry includes 4950 fields organised into 18 instruments designed to fully describe patient’s details about demographics, clinical manifestations, symptoms, histologic details about skin and bone marrow biopsies and aspirate, laboratory features, complications, comorbidities, therapies, and healthcare access. Conclusions: This international Registry for patients with VEXAS syndrome will allow the achievement of a comprehensive knowledge about this new disease in a relatively short time with the final goal to obtain real-world evidence data for daily clinical practice. This project can be found on https://clinicaltrials.gov NCT 05200715
Published: 2022

18. Development and implementation of the AIDA International Registry for patients with Schnitzler’s syndrome

Author: Sota, J, Vitale, A, Więsik-Szewczyk, E, Frassi, M, Lopalco, G, Emmi, G, Govoni, M, de Paulis, A, Marino, A, Gidaro, A, Monti, S, Opris-Belinski, D, Pereira, Rmr, Jahnz-Rózyk, K, Gaggiano, C, Crisafulli, F, Iannone, F, Mattioli, I, Ruffilli, F, Mormile, I, Rybak, K, Caggiano, V, Airò, P, Tufan, A, Gentileschi, S, Ragab, G, Almaghlouth, Ia, Aboul-Fotouh Khalil, A, Cattalini, M, La Torre, F, Tarsia, M, Giardini, Ham, Ali Saad, M, Bocchia, M, Caroni, F, Giani, T, Cinotti, E, Ruscitti, P, Rubegni, P, Dagostin, Ma, Frediani, B, Guler, Aa, Della Casa, F, Maggio, Mc, Recke, A, von Bubnoff, D, Krause, K, Balistreri, A, Fabiani, C, Rigante, Donato, Cantarini, L, Rigante D (ORCID:0000-0001-7032-7779), Sota, J, Vitale, A, Więsik-Szewczyk, E, Frassi, M, Lopalco, G, Emmi, G, Govoni, M, de Paulis, A, Marino, A, Gidaro, A, Monti, S, Opris-Belinski, D, Pereira, Rmr, Jahnz-Rózyk, K, Gaggiano, C, Crisafulli, F, Iannone, F, Mattioli, I, Ruffilli, F, Mormile, I, Rybak, K, Caggiano, V, Airò, P, Tufan, A, Gentileschi, S, Ragab, G, Almaghlouth, Ia, Aboul-Fotouh Khalil, A, Cattalini, M, La Torre, F, Tarsia, M, Giardini, Ham, Ali Saad, M, Bocchia, M, Caroni, F, Giani, T, Cinotti, E, Ruscitti, P, Rubegni, P, Dagostin, Ma, Frediani, B, Guler, Aa, Della Casa, F, Maggio, Mc, Recke, A, von Bubnoff, D, Krause, K, Balistreri, A, Fabiani, C, Rigante, Donato, Cantarini, L, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: The present paper describes the design, development, and implementation of the AutoInflammatory Disease Alliance (AIDA) International Registry specifically dedicated to patients with Schnitzler syndrome. Methods: This is a clinical physician-driven, population- and electronic-based registry implemented for the retrospective and prospective collection of real-life data from patients with Schnitzler’s syndrome; the registry is based on the Research Electronic Data Capture (REDCap) tool, which is thought to collect standardised information for clinical research, and has been realised to change over time according to future scientific acquisitions and potentially communicate with other existing or future similar registries. Results: Since its launch, 112 centres from 23 countries in 4 continents have been involved. Fifty-four have already obtained the approval from their local Ethics Committees. The platform counts 303 users (113 Principal Investigators, 186 Site Investigators, 2 Lead Investigators, and 2 data managers) at current (April 12th 2022). The registry collects baseline and follow-up data using 3922 fields organised into 25 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, laboratory, instrumental exams, therapies, socioeconomic information, and healthcare access. Conclusions: This International Registry for patients with Schnitzler syndrome facilitates standardised data collection, enabling international collaborative projects through data sharing and dissemination of knowledge; in turn, it will shed light into many blind spots characterizing this complex autoinflammatory disorder
Published: 2022

19. Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome

Author: Della Casa, F, Vitale, A, Cattalini, M, La Torre, F, Capozio, G, Del Giudice, E, Maggio, Mc, Conti, Giorgio, Alessio, M, Ogunjimi, B, Ragab, G, Emmi, G, Aragona, E, Giani, T, Lopalco, G, Parronchi, P, Shahram, F, Verrecchia, Elena, Ricci, F, Cardinale, F, Di Noi, Silvia, Nuzzolese, R, Lubrano, R, Patroniti, S, Naddei, R, Sabato, V, Hussein, Ma, Dotta, L, Mastrorilli, V, Gentileschi, S, Tufan, A, Caggiano, V, Hegazy, Mt, Sota, J, Almaghlouth, Ia, Ibrahim, A, Wiȩsik-Szewczyk, E, Ozkiziltas, B, Grosso, S, Frassi, M, Tarsia, M, Pereira, Rmr, Taymour, M, Gaggiano, C, Colella, S, Fabiani, C, Morrone, M, Ruscitti, P, Frediani, B, Spedicato, V, Giardini, Ham, Balistreri, A, Rigante, Donato, Cantarini, L, Conti G (ORCID:0000-0002-8566-9365), Verrecchia E, Di Noi S, Rigante D (ORCID:0000-0001-7032-7779), Della Casa, F, Vitale, A, Cattalini, M, La Torre, F, Capozio, G, Del Giudice, E, Maggio, Mc, Conti, Giorgio, Alessio, M, Ogunjimi, B, Ragab, G, Emmi, G, Aragona, E, Giani, T, Lopalco, G, Parronchi, P, Shahram, F, Verrecchia, Elena, Ricci, F, Cardinale, F, Di Noi, Silvia, Nuzzolese, R, Lubrano, R, Patroniti, S, Naddei, R, Sabato, V, Hussein, Ma, Dotta, L, Mastrorilli, V, Gentileschi, S, Tufan, A, Caggiano, V, Hegazy, Mt, Sota, J, Almaghlouth, Ia, Ibrahim, A, Wiȩsik-Szewczyk, E, Ozkiziltas, B, Grosso, S, Frassi, M, Tarsia, M, Pereira, Rmr, Taymour, M, Gaggiano, C, Colella, S, Fabiani, C, Morrone, M, Ruscitti, P, Frediani, B, Spedicato, V, Giardini, Ham, Balistreri, A, Rigante, Donato, Cantarini, L, Conti G (ORCID:0000-0002-8566-9365), Verrecchia E, Di Noi S, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: Aim of this paper is to illustrate the methodology, design, and development of the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to patients with the Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis (PFAPA) syndrome. Methods: This is a physician-driven, population- and electronic-based registry proposed to gather real-world demographics, clinical, laboratory, instrumental and socioeconomic data from patients suffering from PFAPA syndrome. Data recruitment is realized through the on-line Research Electronic Data Capture (REDCap) tool. This registry is thought to collect standardized information for clinical research leading to solid real-life evidence. The international scope and the flexibility of the registry will facilitate the realization of cutting-edge study projects through the constant updating of variables - as required by future scientific acquisitions - and the possible merging and transfer of data between current and future registries devoted to this disease. Results: One hundred and twelve centers have already been involved from 23 countries and 4 continents starting from August 24th, 2021, to March 21st, 2022. Fifty-five out of 112 have already obtained the formal approval from their local Ethics Committees. At current, the platform counts 287 users (108 principal investigators, 179 site investigators, 2 lead investigators, and 2 data managers). The registry collects retrospective and prospective data using 3845 fields organized into 24 instruments, including PFAPA patient’s demographics, medical histories, symptoms, triggers/risk factors, therapies, and impact on the healthcare systems. Conclusions: The development of the AIDA International Registry for patients with PFAPA syndrome will enable the on-line collection of standardized data prompting real-life studies through the connection of worldwide groups of physicians and researchers. This project can be found on https://clinicaltrials.gov
Published: 2022

20. Development and implementation of the AIDA International Registry for patients with Still’s disease

Author: Vitale, A, Della Casa, F, Lopalco, G, Pereira, Rm, Ruscitti, P, Giacomelli, R, Ragab, G, La Torre, F, Bartoloni, E, Del Giudice, E, Lomater, C, Emmi, G, Govoni, M, Maggio, Mc, Maier, A, Makowska, J, Ogunjimi, B, Sfikakis, Pp, Sfriso, P, Gaggiano, C, Iannone, F, Dagostin, Ma, Di Cola, I, Navarini, L, Ahmed Mahmoud, Aa, Cardinale, F, Riccucci, I, Paroli, Mp, Marucco, Em, Mattioli, I, Sota, J, Abbruzzese, A, Antonelli, Ipb, Cipriani, P, Tufan, A, Fabiani, C, Ramadan, Mm, Cattalini, M, Kardas, Rc, Sebastiani, Gd, Giardini, Ham, Hernández-Rodríguez, J, Mastrorilli, V, Więsik-Szewczyk, E, Frassi, M, Caggiano, V, Telesca, S, Giordano, Hf, Guadalupi, E, Balistreri, A, Rigante, Donato, Cantarini, L., Rigante D (ORCID:0000-0001-7032-7779), Vitale, A, Della Casa, F, Lopalco, G, Pereira, Rm, Ruscitti, P, Giacomelli, R, Ragab, G, La Torre, F, Bartoloni, E, Del Giudice, E, Lomater, C, Emmi, G, Govoni, M, Maggio, Mc, Maier, A, Makowska, J, Ogunjimi, B, Sfikakis, Pp, Sfriso, P, Gaggiano, C, Iannone, F, Dagostin, Ma, Di Cola, I, Navarini, L, Ahmed Mahmoud, Aa, Cardinale, F, Riccucci, I, Paroli, Mp, Marucco, Em, Mattioli, I, Sota, J, Abbruzzese, A, Antonelli, Ipb, Cipriani, P, Tufan, A, Fabiani, C, Ramadan, Mm, Cattalini, M, Kardas, Rc, Sebastiani, Gd, Giardini, Ham, Hernández-Rodríguez, J, Mastrorilli, V, Więsik-Szewczyk, E, Frassi, M, Caggiano, V, Telesca, S, Giordano, Hf, Guadalupi, E, Balistreri, A, Rigante, Donato, Cantarini, L., and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder. Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients’ management. The collection of standardized data is thought to bring knowledge about real-life clinical research and potentially communicate with other existing and future Registries dedicated to Still’s disease. Moreover, it has been conceived to be flexible enough to easily change according to future scientific acquisitions. Results: Starting from June 30th to February 7th, 2022, 110 Centers from 23 Countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 4449 fields organized into 14 instruments, including patient’s demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: This international Registry for patients with Still’s disease will allow a robust clinical research through collection of standardized data, international consultation, dissemination of knowledge, and implementation of observational studies based on wide cohorts of patients followed-up for very long periods. Solid evidence drawn from “real-life” data represents the ultimate goal of t
Published: 2022

21. Development and implementation of the AIDA International Registry for patients with non-infectious uveitis

Author: Della Casa, F, Vitale, A, Guerriero, S, Sota, J, Cimaz, R, Ragab, G, Ruscitti, P, Pereira, Rmr, Minoia, F, Del Giudice, E, Emmi, G, Lomater, C, Monti, S, Canofari, C, Gaggiano, C, Alessio, G, Miserocchi, E, Conforti, A, Dagostin, Ma, Mapelli, C, Paroli, Mp, Parretti, V, Albano, V, Favale, R, Marelli, L, Hegazy, Mt, Cipriani, P, Antonelli, Ipb, Caggiano, V, Aragona, E, Laymouna, Ah, Tosi, Gm, Tarsia, M, Cattalini, M, La Torre, F, Lopalco, G, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Giordano, Hf, Frediani, B, Shinjo, Sk, Rigante, Donato, Sfikakis, Pp, Balistreri, A, Hussein, Ma, Amin, Rh, Cantarini, L, Fabiani, C, Rigante D (ORCID:0000-0001-7032-7779), Della Casa, F, Vitale, A, Guerriero, S, Sota, J, Cimaz, R, Ragab, G, Ruscitti, P, Pereira, Rmr, Minoia, F, Del Giudice, E, Emmi, G, Lomater, C, Monti, S, Canofari, C, Gaggiano, C, Alessio, G, Miserocchi, E, Conforti, A, Dagostin, Ma, Mapelli, C, Paroli, Mp, Parretti, V, Albano, V, Favale, R, Marelli, L, Hegazy, Mt, Cipriani, P, Antonelli, Ipb, Caggiano, V, Aragona, E, Laymouna, Ah, Tosi, Gm, Tarsia, M, Cattalini, M, La Torre, F, Lopalco, G, Więsik-Szewczyk, E, Frassi, M, Gentileschi, S, Giordano, Hf, Frediani, B, Shinjo, Sk, Rigante, Donato, Sfikakis, Pp, Balistreri, A, Hussein, Ma, Amin, Rh, Cantarini, L, Fabiani, C, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Introduction: The aim of this paper is to point out the design, development and deployment of the AutoInflammatory Disease Alliance(AIDA) International Registry for paediatric and adult patients with non-infectious uveitis(NIU). Methods: This is a physician-driven, population- and electronic-based registry implemented for both retrospective and prospective collection of real-world demographics, clinical, laboratory, instrumental and socioeconomic data of patients with uveitis and other non-infectious inflammatory ocular diseases recruited through the AIDA Network. Data recruitment, based on the Research Electronic Data Capture (REDCap) tool, is thought to collect standardised information for real-life research and has been developed to change over time according to future scientific acquisitions and potentially communicate with other similar instruments. Security, data quality and data governance are cornerstones of this platform. Results: Ninety-five centres have been involved from 19 countries and four continents from 24 March to 16 November 2021. Forty-eight out of 95 have already obtained the approval from their local ethics committees. At present, the platform counts 259 users (95 principal investigators, 160 site investigators, 2 lead investigators, and 2 data managers). The AIDA Registry collects baseline and follow-up data using 3943 fields organised into 13 instruments, including patient’s demographics, history, symptoms,trigger/risk factors, therapies and health care utilization for patients with NIU. Conclusions: The development of the AIDA Registry for patients with NIU will facilitate the collection of standardised data leading to real-world evidence and enabling international multicentre collaborative research through inclusion of patients and their families worldwide.
Published: 2022

22. Development and implementation of the AIDA International Registry for patients with non-infectious scleritis

Author: Della Casa, F, Vitale, A, Pereira, Rm, Guerriero, S, Ragab, G, Lopalco, G, Cattalini, M, Mattioli, I, Parronchi, P, Paroli, Mp, Del Giudice, E, Gaggiano, C, Dagostin, Ma, Albano, V, Soliman, Mm, Colella, S, Nascimbeni, G, Sota, J, Antonelli, Ipb, Alessio, G, Caggiano, V, Tufan, A, Amin, Rh, Tarsia, M, Ghanema, M, Iannone, F, Ricci, F, La Torre, F, Więsik-Szewczyk, E, Conticini, E, Gentileschi, S, Dammacco, R, Cimaz, R, Frediani, B, Abbruzzese, A, Ruscitti, P, Tosi, Gm, Giordano, Hf, Conforti, A, Balistreri, A, Rigante, Donato, Cantarini, L, Fabiani, C, Rigante D (ORCID:0000-0001-7032-7779), Della Casa, F, Vitale, A, Pereira, Rm, Guerriero, S, Ragab, G, Lopalco, G, Cattalini, M, Mattioli, I, Parronchi, P, Paroli, Mp, Del Giudice, E, Gaggiano, C, Dagostin, Ma, Albano, V, Soliman, Mm, Colella, S, Nascimbeni, G, Sota, J, Antonelli, Ipb, Alessio, G, Caggiano, V, Tufan, A, Amin, Rh, Tarsia, M, Ghanema, M, Iannone, F, Ricci, F, La Torre, F, Więsik-Szewczyk, E, Conticini, E, Gentileschi, S, Dammacco, R, Cimaz, R, Frediani, B, Abbruzzese, A, Ruscitti, P, Tosi, Gm, Giordano, Hf, Conforti, A, Balistreri, A, Rigante, Donato, Cantarini, L, Fabiani, C, and Rigante D (ORCID:0000-0001-7032-7779)
Abstract: Introduction: This article points out the design, methods, development and deployment of the international registry promoted by the AutoInflammatory Disease Alliance (AIDA) Network with the aim to define and assess paediatric and adult patients with immune-mediated scleritis. Methods: This registry collects both retrospec-tive and prospective real-world data from patients with non-infectious scleritis through the Research Electronic Data Capture (REDCap) tool and aims to promote knowledge and real-life evidence from patients enrolled worldwide; the registry also allows the collection of standardised data, ensuring the highest levels of security and anonymity of patients’ data and flexibility to change according to scientific acquisitions over time. The communication with other similar registries has been also ensured in order to pursue the sustainability of the project with respect to the adaptation of collected data to the most diverse research projects. Results: Since the launch of the registry, 99 centres have been involved from 20 countries and four continents. Forty-eight of the centres have already obtained a formal approval from their local ethics committees. At present, the platform counts 259 users (95 principal investigators, 160 site investigators, 2 lead investigators, and 2 data managers); the platform collects baseline and follow-up data using 3683 fields organised into 13 instruments, including patient’s demographics, history, symptoms, trigger or risk factors, therapies and health care utilization. Conclusions: The development of the AIDA International Registry for patients with non-infectious scleritis will allow solid research on this rare condition. Real-world evidence result-ing from standardised real-life data will lead to the optimisation of routine clinical and therapeutic management, which are currently limited by the rarity of this ocular inflammatory condition.
Published: 2022

23. AB1265 BIOTECHNOLOGICAL AGENTS IN PEDIATRIC-ONSET SCLERITIS

Author: Vitale, A., primary, Gaggiano, C., additional, Berlengiero, V., additional, Fabiani, C., additional, Ricci, F., additional, Nascimbeni, G., additional, Caggiano, V., additional, Tosi, G. M., additional, Frediani, B., additional, Cattalini, M., additional, and Cantarini, L., additional
Published: 2022
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24. POS1373 THE DIAGNOSTIC ROLE OF PATHERGY TEST IN PATIENTS WITH BEHÇET’S DISEASE FROM WESTERN EUROPE

Author: Vitale, A., primary, Berlengiero, V., additional, Sota, J., additional, Barneschi, S., additional, Mourabi, M., additional, Fabiani, C., additional, Gentileschi, S., additional, Caggiano, V., additional, Tosi, G. M., additional, Frediani, B., additional, and Cantarini, L., additional
Published: 2022
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25. Development and Implementation of the AIDA International Registry for Patients With Still's Disease

Author: Vitale, A. Della Casa, F. Lopalco, G. Pereira, R.M. Ruscitti, P. Giacomelli, R. Ragab, G. La Torre, F. Bartoloni, E. Del Giudice, E. Lomater, C. Emmi, G. Govoni, M. Maggio, M.C. Maier, A. Makowska, J. Ogunjimi, B. Sfikakis, P.P. Sfriso, P. Gaggiano, C. Iannone, F. Dagostin, M.A. Di Cola, I. Navarini, L. Ahmed Mahmoud, A.A. Cardinale, F. Riccucci, I. Paroli, M.P. Marucco, E.M. Mattioli, I. Sota, J. Abbruzzese, A. Antonelli, I.P.B. Cipriani, P. Tufan, A. Fabiani, C. Ramadan, M.M. Cattalini, M. Kardas, R.C. Sebastiani, G.D. Giardini, H.A.M. Hernández-Rodríguez, J. Mastrorilli, V. Więsik-Szewczyk, E. Frassi, M. Caggiano, V. Telesca, S. Giordano, H.F. Guadalupi, E. Giani, T. Renieri, A. Colella, S. Cataldi, G. Gentile, M. Fabbiani, A. Al-Maghlouth, I.A. Frediani, B. Balistreri, A. Rigante, D. Cantarini, L. The Autoinflammatory Diseases Alliance (AIDA) Network
Abstract: Objective: Aim of this paper is to present the design, construction, and modalities of dissemination of the AutoInflammatory Disease Alliance (AIDA) International Registry for patients with systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), which are the pediatric and adult forms of the same autoinflammatory disorder. Methods: This Registry is a clinical, physician-driven, population- and electronic-based instrument implemented for the retrospective and prospective collection of real-world data. The collection of data is based on the Research Electronic Data Capture (REDCap) tool and is intended to obtain evidence drawn from routine patients' management. The collection of standardized data is thought to bring knowledge about real-life clinical research and potentially communicate with other existing and future Registries dedicated to Still's disease. Moreover, it has been conceived to be flexible enough to easily change according to future scientific acquisitions. Results: Starting from June 30th to February 7th, 2022, 110 Centers from 23 Countries in 4 continents have been involved. Fifty-four of these have already obtained the approval from their local Ethics Committees. Currently, the platform counts 290 users (111 Principal Investigators, 175 Site Investigators, 2 Lead Investigators, and 2 data managers). The Registry collects baseline and follow-up data using 4449 fields organized into 14 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, therapies and healthcare access. Conclusions: This international Registry for patients with Still's disease will allow a robust clinical research through collection of standardized data, international consultation, dissemination of knowledge, and implementation of observational studies based on wide cohorts of patients followed-up for very long periods. Solid evidence drawn from “real-life” data represents the ultimate goal of this Registry, which has been implemented to significantly improve the overall management of patients with Still's disease. NCT 05200715 available at https://clinicaltrials.gov/. Copyright © 2022 Vitale, Della Casa, Lopalco, Pereira, Ruscitti, Giacomelli, Ragab, La Torre, Bartoloni, Del Giudice, Lomater, Emmi, Govoni, Maggio, Maier, Makowska, Ogunjimi, Sfikakis, Sfriso, Gaggiano, Iannone, Dagostin, Di Cola, Navarini, Ahmed Mahmoud, Cardinale, Riccucci, Paroli, Marucco, Mattioli, Sota, Abbruzzese, Antonelli, Cipriani, Tufan, Fabiani, Ramadan, Cattalini, Kardas, Sebastiani, Giardini, Hernández-Rodríguez, Mastrorilli, Więsik-Szewczyk, Frassi, Caggiano, Telesca, Giordano, Guadalupi, Giani, Renieri, Colella, Cataldi, Gentile, Fabbiani, Al-Maghlouth, Frediani, Balistreri, Rigante and Cantarini.
Published: 2022

26. Plural skills for the learning organization. The Little Genius International School project

Author: Caggiano, V. and Caggiano, V.
Subjects: soft skills, learning organization, school, emotional literacy. [soft skills, organizzazione dell’apprendimento, scuola, alfabetizzazione emotiva. Keywords]
Abstract: Nella società, i cambiamenti quotidiani e nei luoghi di lavoro, la percezione delle soft skills sta superando la formazione delle hard skills. La discussione nasce dai cambiamenti necessari per interagire nell’ecosistema e nell’organizzazione dell’apprendimento. Da diversi studi condotti da organizzazioni internazionali, il quadro per un’educazione del futuro deve coinvolgere lo sviluppo, durantela scuola, delle competenze trasversali per lavoratori e organizzazioni. Le scuole quindi come organizzazioni che apprendono, definiscono una serie di azioni per rafforzare la gestione della conoscenza e l’apprendimento organizzativo. Gli individui e le organizzazioni dovranno imparare per tutta la vita a sviluppare le proprie capacità di interagire nell’ecosistema educativo. In particolare, le qualità delle comunità di apprendimento (riflessive, dialogiche, cooperative) saranno la condizione per affrontare le difficoltà del nostro tempo. Se si vuole diventare cittadini attivi in una democrazia giusta e istruttiva all’inizio del nuovo secolo, le scuole dovrebbero incoraggiare i giovani ad acquisire una capacità di discernimento. Questo contributo mira a sviluppare l’auspicata riflessione pedagogica in dialogo con l’Esempio di Little Genius International School, ormai diventato un criterio di classificazione e identificazione nelle classifiche internazionali, e, in casi virtuosi, sembra rispondere alle esigenze negoziate con gli stakeholder. The daily changes in society and working places, the perception about soft skills is overcoming the hard skills training in society. The discussion arises from the necessary changes needed to interact in ecosystem and learning organization. From several studies carried out by international organizations, the framework for an education for the future must engage the development, while at school, of the soft skills for workers and organizations. Schools as learning organizations, define a set of actions to strengthen knowledge management and organizational learning. Individuals and organizations will need to learn throughout their lives to develop their skills to interact in educational ecosystem. In particular, the qualities of learning communities (reflexive, dialogic, cooperative) will be the condition for addressing these predicaments of our time. The distinctive capability which schools should encourage young people to acquire if all are to become active citizens in a just, learning democracy at the turn of a new century. This contribution aims to develop the desired pedagogical reflection in dialogue with the Example of Little Genius International School, which has become a criterion of classification and identification in international rankings, and, in virtuous cases, seems to respond to the needs negotiated with the stakeholders.
Published: 2021

27. Nuova Secondaria – n. 2, ottobre 2021 - Anno XXXIX - ISSN 1828-4582 Pandemia & Tecnologia. Competenze per l’insegnamento: confronto tra insegnanti delle secondarie portoghesi e italiani

Author: caggiano, V. and Caggiano, V.
Abstract: The present study aimed to assess how teachers, from Portugal and Italian, perceive the use of IT in the teaching process, especially during the pandemic period of the new coronavirus. the scientific literature was first reviewed and then a questionnaire was elaborated, which was used to identify the teacher’s perception regard the use of IT in teaching, especially during the period of education. pandemic of COVID-19, where they continued teaching in the remote format. The paper reports a descriptive analysis integrated by a network analysis and a search for causal relationships among the variables that have been investigated. Throughout the development of this study, there were situations that ended up limiting some aspects of the research.
Published: 2021

28. Pandemic & Technology Teaching Skills: Comparison of Portuguese and Italian secondary school teachers

Author: Caggiano V. and Caggiano, V.
Subjects: Pedagogy, technology, teaching skill, life skills, distance course
Abstract: The present study aimed to assess how teachers, from Portugal and Italian, perceive the use of IT in the teaching process, especially during the pandemic period of the new coronavirus. the scientific literature was first reviewed and then a questionnaire was elaborated, which was used to identify the teacher’s perception regard the use of IT in teaching, especially during the period of education. pandemic of COVID- 19, where they continued teaching in the remote format. The paper reports a descriptive analysis integrated by a network analysis and a search for causal relationships among the variables that have been investigated. Throughout the development of this study, there were situations that ended up limiting some aspects of the research.
Published: 2021

29. Plural skills for the learning organization. The Little Genius International School

Author: Caggiano, V. and Caggiano, V.
Subjects: soft skills, organizzazione dell’apprendimento, scuola, alfabetizzazione emotiva
Abstract: Nella società, i cambiamenti quotidiani e nei luoghi di lavoro, la percezione delle soft skills sta superando la formazione delle hard skills. La discussione nasce dai cambiamenti necessari per interagire nell’ecosistema e nell’organizzazione dell’apprendimento. Da diversi studi condotti da organizzazioni internazionali, il quadro per un’educazione del futuro deve coinvolgere lo sviluppo, durante la scuola, delle competenze trasversali per lavoratori e organizzazioni. Le scuole quindi come organizzazioni che apprendono, definiscono una serie di azioni per rafforzare la gestione della conoscenza e l’apprendimento organizzativo. Gli individui e le organizzazioni dovranno imparare per tutta la vita a sviluppare le proprie capacità di interagire nell’ecosistema educativo. In particolare, le qualità delle comunità di apprendimento (riflessive, dialogiche, cooperative) saranno la condizione per affrontare le difficoltà del nostro tempo. Se si vuole diventare cittadini attivi in una democrazia giusta e istruttiva all’inizio del nuovo secolo, le scuole dovrebbero incoraggiare i giovani ad acquisire una capacità di discernimento. Questo contributo mira a sviluppare l’auspicata riflessione pedagogica in dialogo con l’Esempio di Little Genius International School, ormai diventato un criterio di classificazione e identificazione nelle classifiche internazionali, e,in casi virtuosi, sembra rispondere alle esigenze negoziate con gli stakeholder. The daily changes in society and working places, the perception about soft skills is overcoming the hard skills training in society. The discussion arises from the necessary changes needed to interact in ecosystem and learning organization. From several studies carried out by international organizations, the framework for an education for the future must engage the development, while at school, of the soft skills for workers and organizations. Schools as learning organizations, define a set of actions to strengthen knowledge management and organizational learning. Individuals and organizations will need to learn throughout their lives to develop their skills to interact in educational ecosystem. In particular, the qualities of learning communities (reflexive, dialogic, cooperative) will be the condition for addressing these predicaments of our time. The distinctive capability which schools should encourageyoung people to acquire if all are to become active citizens in a just, learning democracy at the turn of a new century. This contribution aims to develop the desired pedagogical reflection in dialogue with the Example of Little Genius International School, which has become a criterion of classification and identification in international rankings, and, in virtuous cases, seems to respond to the needs negotiated with the stakeholders. Keywords: soft skills, learning organization, school, emotional literacy
Published: 2021

30. Le pedagogie della Musica e le competenze degli insegnanti nella scuola dell’infanzia. Dalle Voci italiane all’Atelier Creativo

Author: Caggiano, V. and Caggiano, V.
Subjects: ComputingMilieux_COMPUTERSANDEDUCATION, pedagogy, music, skills, teacher, school
Abstract: The contribution focuses on topics on the skills of kindergarten teachers with respect to teaching music. These issues are addressed in a historical dimension that sees the changing role of music pedagogies, exploring and gathering inspiration for new models of teaching and learning music from Italian voices. We present a case study created within the Department of Education of the University of Rome TRE. The presented Atelier model represents a learning path that can be transferred to kindergarten teachers called to the pedagogy of music. The analysis of the literature and the presentation of the case allow to bring to light the need to train in the crucial skills of the individual human resources involved, even at the organizational level of the school system. The conclusions reached make it possible to highlight the need to activate projects and interventions that can innovate and encourage the teaching and study of music in Italian schools.
Published: 2021

31. Rilevazione e valutazione delle competenze sociali e comunicative (social soft skills) in docenti di scuola secondaria superiore / Detection and evaluation of social and communication skills (social soft skills) in high secondary school teachers

Author: Biasi V., Caggiano V., Ciraci A. M., AAVV, Biasi, V., Caggiano, V., and Ciraci, A. M.
Subjects: valutazione BIP questionnaire, evaluation, questionario BIP, competenze sociali, competenze trasversali degli insegnanti, social competence, teachers’ soft skills
Abstract: Today we are witnessing a gradual institutional legitimization of a mission of the education and training system aimed to developing transversal skills. Here we present the results of an empirical survey for evaluate some social competences recognized in the international literature as fundamental for the teaching profession: Sociability, Ability to make contacts, Sensitivity, Team orientation, Assertiveness. They were detected through the administration – to 80 teachers of upper secondary schools of different disciplines - of the scale on Social Competences of BIP Questionnaire (Business-focused Inventory of Personality, by Hossiep & Paschen, 2003), adapted to the Italian population by Fossati and Ciancaleoni (2013). The Sociability score is below the average of the Italian population: so, the professors examined should improve the relational ability and reduce conflict situations. With regard to the other factors, scores are around the average, confirming that soft skills of this teachers, have not been really developed and specific teacher training programs are needed. There are no significant differences with respect to age, while, as far as gender is concerned, women are more sensitive, capable of establishing contacts and team-oriented. Assertiveness levels are common for both sexes. Furthermore, the “multi-dimensional” character of transversal social competences is highlighted.
Published: 2020

32. Soft Skills in Engineers, a Relevant Field of Research:Exploring and Assessing Skills in Italian Engineering Students

Author: Caggiano V., Redomero-Echeverría T., Poza-Lujan J. L., andBelleza A., Caggiano, V., Redomero-Echeverría, T., Poza-Lujan, J. L., and Andbelleza, A.
Published: 2020

33. Soft skills and Jazz in Curriculum design

Author: Caggiano, V., D’Amante M. F., Caggiano, V., and D’Amante, M. F.
Subjects: ComputingMilieux_THECOMPUTINGPROFESSION, ComputingMilieux_COMPUTERSANDEDUCATION, soft skills, music education, humanistic approach [Key words]
Abstract: Continuous changing in educational trends and availability of mass qualified personnel has made tougher the competition for job acquisition and job sustainability. The focus of Higher Education Institutions has turned to the value of human capital and its ability to produce creative and independent leaders as a primary investment for future growth. To get an edge over the competitors, students are left with no choice but to add value to their hard skills with soft skills to exhibit their true potential. Hard skills are academic skills, experience and level of expertise, while soft skills are self-developed, interactive, communicative, human and transferable skills. In this article, the authors present a methodological intervention used during a summer school, in which, behind the jazz metaphor the authors discuss suggestions for improving methods and materials, and why this practice can generate an authentic human development.
Published: 2020

34. Midbrain circuits that set locomotor speed and gait selection

Author: Caggiano, V., Leiras, R., Goi-Erro, H., Masini, D., Bellardita, C., Bouvier, J., Caldeira, V., Fisone, G., and Kiehn, O.
Subjects: Neural circuitry -- Physiological aspects, Mesencephalon -- Physiological aspects, Human locomotion -- Observations -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Locomotion is a fundamental motor function common to the animal kingdom. It is implemented episodically and adapted to behavioural needs, including exploration, which requires slow locomotion, and escape behaviour, which necessitates faster speeds. The control of these functions originates in brainstem structures, although the neuronal substrate(s) that support them have not yet been elucidated. Here we show in mice that speed and gait selection are controlled by glutamatergic excitatory neurons (GlutNs) segregated in two distinct midbrain nuclei: the cuneiform nucleus (CnF) and the pedunculopontine nucleus (PPN). GlutNs in both of these regions contribute to the control of slower, alternating-gait locomotion, whereas only GlutNs in the CnF are able to elicit high-speed, synchronous-gait locomotion. Additionally, both the activation dynamics and the input and output connectivity matrices of GlutNs in the PPN and the CnF support explorative and escape locomotion, respectively. Our results identify two regions in the midbrain that act in conjunction to select context-dependent locomotor behaviours., Author(s): V. Caggiano (corresponding author) [1]; R. Leiras (corresponding author) [1, 2]; H. Goi-Erro [1, 2]; D. Masini [3]; C. Bellardita [1, 2]; J. Bouvier [1]; V. Caldeira [1]; G. [...]
Published: 2018
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35. Crowdsourcing digital health measures to predict Parkinson’s disease severity: the Parkinson’s Disease Digital Biomarker DREAM Challenge

Author: Sieberts, S.K., Schaff, J., Duda, M., Pataki, B.Á., Sun, M., Snyder, P., Daneault, J.F., Parisi, F., Costante, G., Rubin, U., Banda, P., Chae, Y., Chaibub Neto, E., Dorsey, E.R., Aydın, Z., Chen, A., Elo, L.L., Espino, C., Glaab, E., Goan, E., Golabchi, F.N., Görmez, Y., Jaakkola, M.K., Jonnagaddala, J., Klén, R., Li, D., McDaniel, C., Perrin, D., Perumal, T.M., Rad, N.M., Rainaldi, E., Sapienza, S., Schwab, P., Shokhirev, N., Venäläinen, M.S., Vergara-Diaz, G., Zhang, Y., Abrami, A., Adhikary, A., Agurto, C., Bhalla, S., Bilgin, H., Caggiano, V., Cheng, J., Deng, E., Gan, Q., Girsa, R., Han, Z., Heisig, S., Huang, K., Jahandideh, S., Kopp, W., Kurz, C.F., Lichtner, G., Norel, R., Raghava, G.P.S., Sethi, T., Shawen, N., Tripathi, V., Tsai, M., Wang, T., Wu, Y., Zhang, J., Zhang, X., Wang, Y., Guan, Y., Brunner, D., Bonato, P., Mangravite, L.M., Omberg, L., AGÜ, Mühendislik Fakültesi, Elektrik - Elektronik Mühendisliği Bölümü, Aydin, Zafer, Fonds National de la Recherche - FnR [sponsor], and Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group) [research center]
Subjects: Movement disorders, Parkinson's disease, Biotechnologie [F06] [Sciences du vivant], Neurology [D14] [Human health sciences], Medicine (miscellaneous), Disease, Multidisciplinaire, généralités & autres [F99] [Sciences du vivant], 0302 clinical medicine, Health Information Management, Evaluation methods, Biotechnology [F06] [Life sciences], Multidisciplinary, general & others [D99] [Human health sciences], 0303 health sciences, Outcome measures, Computer Science Applications, machine learning, smart sensors, bradykinesia, Biomarker (medicine), Technology Platforms, medicine.symptom, medicine.medical_specialty, Multidisciplinaire, généralités & autres [D99] [Sciences de la santé humaine], Computer applications to medicine. Medical informatics, R858-859.7, Health Informatics, Multidisciplinary, general & others [F99] [Life sciences], Digital Biomarker, Crowdsourcing, Article, VALIDATION, Parkinson’s Disease, 03 medical and health sciences, Physical medicine and rehabilitation, Machine learning, medicine, 030304 developmental biology, mobile phone, GENDER-DIFFERENCES, Neurologie [D14] [Sciences de la santé humaine], business.industry, biomarkers, medicine.disease, tremor, Digital health, nervous system diseases, Clinical trial, dyskinesia, Dyskinesia, Cardiovascular and Metabolic Diseases, HYPOTHESIS TESTS, business, Biomarkers, 030217 neurology & neurosurgery
Abstract: Consumer wearables and sensors are a rich source of data about patients’ daily disease and symptom burden, particularly in the case of movement disorders like Parkinson’s disease (PD). However, interpreting these complex data into so-called digital biomarkers requires complicated analytical approaches, and validating these biomarkers requires sufficient data and unbiased evaluation methods. Here we describe the use of crowdsourcing to specifically evaluate and benchmark features derived from accelerometer and gyroscope data in two different datasets to predict the presence of PD and severity of three PD symptoms: tremor, dyskinesia, and bradykinesia. Forty teams from around the world submitted features, and achieved drastically improved predictive performance for PD status (best AUROC = 0.87), as well as tremor- (best AUPR = 0.75), dyskinesia- (best AUPR = 0.48) and bradykinesia-severity (best AUPR = 0.95)., npj Digital Medicine, 4 (1), ISSN:2398-6352
Published: 2021

36. Il mio nonno preferito. Relazioni, stili e valore educativo. Uno studio comparativo internazionale

Author: Caggiano, V. and Caggiano, V.
Subjects: Nonni, stili educativi, Famiglia, Valori
Abstract: Il contributo intende esaminare il tema della relazione tra nonni e nipoti, avvalendosi di un approccio multidisciplinare. Si esplora il vissuto esperenziale di due gruppi diversi, uno composto da famiglie italiane e l’altro da famiglie nigeriane. Al campione rappresentativo di nipoti africani e italiani è stato somministrato un questionario che approfondisce tre aree tematiche: il tipo di attività svolte in compagnia del nonno/a preferito,la frequenza delle attività, la funzione educativa in relazione al ruolo. I risultati hanno rivelato che i nipoti hanno un nonno preferito, e che i nipoti italiani dichiarano di avere relazioni più intense con le nonne rispetto ai nonni, confermando così la letteratura empirica internazionale. Sono emerse, inoltre, ulteriori differenze nella partecipazione alle attività che scandiscono il tempo con i nonni. Naturalmente, l’elaborazione dei dati ottenuti deve tener conto dei fattori culturali che possono aver influenzato le percezioni e le interazioni dei nipoti con i nonni. Tuttavia, sono necessarie ulteriori ricerche per accertare la coerenza e la generalizzabilità dei risultati.
Published: 2019

37. Soft Skills degli insegnanti: verso un nuovo ambito di ricerca e formazione nella scuola secondaria italiana Soft Skills of teachers: towards a new field of research and training

Author: Biasi V., Caggiano V., Ciraci A. M., Biasi, V., Caggiano, V., and Ciraci, A. M.
Subjects: BIP questionnaire, Evaluation, Socio-relational and Communicative compe- tences, Teachers’ Soft skills, Teacher training Competenze socio-relazionali e comunicative, Competenze trasversali degli insegnanti, Formazione degli insegnanti, Questionario BIP, Valutazione
Abstract: Il riconoscimento del ruolo delle competenze trasversali nella scuola rende necessario l’approfondimento di tale ambito di ricerca per rispondere alla ne- cessità di una formazione di tali competenze per la professione docente. Dopo una rassegna di studi nazionali e internazionali, sia teorici sia empirici, si evidenzia il carattere ‘multidimensionale’ delle competenze trasversali di tipo sociale cercando di identificare i principali fattori comuni alle varie clas- sificazioni proposte in letteratura. Le evidenze presentate contribuiscono a definire il significato delle competenze trasversali socio-relazionali e comu- nicative del docente come la capacità di mettersi in relazione con l’altro ascol- tando le sue esigenze in modo empatico e collaborativo. Vengono riassunti gli esiti principali di un’indagine empirica volta ad esplorare alcune compe- tenze socio-relazionali (Socievolezza, Capacità di stabilire contatti, Sensibilità, Orientamento al team, Assertività), rilevate attraverso la somministrazione a 80 docenti di scuole secondarie superiori, della scala sulle “Competenze So- ciali” del Questionario BIP (Business-focused Inventory of Personality) di Hos- siep, Paschen (2003), adattato alla popolazione italiana da Fossati e Ciancaleoni (2013). In sintesi, si rileva che i docenti esaminati necessitano di sviluppare ul- teriormente le loro competenze trasversali di tipo socio-relazionale e comu- nicativo: ciò è possibile grazie specifici programmi di formazione. The recognition of the role of transversal skills in the school makes it neces- sary to deepen this field of research in order to respond to the need for train- ing of these skills for the teaching profession. After a review of national and international studies, both theoretical and empirical, the “multi-dimensional” character of transversal social competences is highlighted, trying to identify the main factors common to the various classifications proposed in the liter- ature. The evidence presented helps to define the significance of the socio- relational and communicative transversal skills of the teacher as the ability to relate to the other by listening to his needs in an empathic and collaborative way. The main outcomes of an empirical survey are also presented, aimed at exploring some socio-relational competences recognized in international lit- erature as relevant for the teaching profession (Sociability, Ability to establish contacts, Sensitivity, Team orientation, Assertiveness); detected through the administration to 80 teachers of high schools of different disciplines, of the “Social Competence” scale of BIP Questionnaire (Business-focused Inventory of Personality, by Hossiep, Paschen (2003), adapted to the Italian population by Fossati and Ciancaleoni (2013). In summary, it is noted that the professors examined need to further develop their transversal socio-relational and com- municative skills: this is possible thanks to specific training programs.
Published: 2019

38. Hard work on soft skills

Author: Caggiano,V. and Caggiano, V.
Published: 2019

39. Education to leadership: Shakespeare’s exempla and soft skills

Author: Caggiano, V. and Caggiano, V.
Subjects: Education, Shakespeare, Exempla, Leadership, Transversal skills
Abstract: This article comes from the proposal of an educational laboratory provided within the summer school program at the Department of Pedagogy of Innovation of the University of Turku (Finland). The laboratory is thought as an educational activity aimed at the improvement of transversal skills, specifically the competence of leadership. Through the study of two works by Shakespeare, Richard II and King Lear, the two plays and their protagonists are analyzed in order to explore leadership put into practice. This positive experience leads us to reflect and propose new educational models that place the study of the classics at the center of an integral education
Published: 2018

40. Talent AndTalent Management In Organizations

Author: KARAMI, M., CAGGIANO, V., BELLEZZA, A., Karami, M., Caggiano, V., and Bellezza, A.
Subjects: InformationSystems_GENERAL, Talent, Talent Management, Talent Pool, Employee [KEYWORDS], ComputingMilieux_THECOMPUTINGPROFESSION, GeneralLiterature_MISCELLANEOUS
Abstract: The main aim of this paper is to develop a conceptual framework for literature on the consequences of talented employees and talent management. Talent management is one of the most important issues in all organizations. It is very important to identify the talented employees and use them in strategic jobs. This article is to review near the past twenty years of the importance of using talents. At the result of this research, provide the necessary information and knowledge in the field of discovering and employing valuecreation and talent management process in the all organizations.
Published: 2018

41. Probabilistic Detection and Tracking of Faces in Video

Author: Boccignone, G., primary, Caggiano, V., additional, Di Fiore, G., additional, and Marcelli, A., additional
Published: 2005
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42. Liderazgo educativo en centros de secundaria. Relación con la percepción y la satisfacción laboral del profesorado

Author: De la Fuente-Anuncibay, González-Bernal J., De Diego-Vallejo R., Caggiano V., De la, Fuente-Anuncibay, González-Bernal, J., De Diego-Vallejo, R., and Caggiano, V.
Subjects: School organization, beliefs, organizational culture, secondary education. [Keywords]
Abstract: The culture throughout the years has been to refer to a product of the interaction of society, to be a key success factor in organizations activity. The importance of this concept for an organization is the transmission of values and philosophies, socialization of its members, staff motivation, cohesion and commitment to important goals. The aim of this study is to analyze aspects of organizational culture building on the perception of teachers in Spanish schools. We performed a study on variables related to organizational culture drawing on the Icoe inventory, based on a sample of 52 schools and 661 teachers. The statistical analyses, the factor analysis and Anova are perfomed through SPSS 21. The results obtained indicate that teachers perceive their center’s organizational culture quite positive and homogeneaous, feeling a good social environment, communication, relationships and integration, work commitment, impartiality, equity and recognition. The existence of differences in scores by type of center and episodic knowledge of severe physical or verbal violence. By contrasts, they are less significant in terms of age and experience, the size of the center, gender and type of population. Learning a center’s culture starting from participants’ perceptions, gives us an approximate idea of what is ideologically shared about a center and, this analysis helps us to reflect on the strength or weakness of the existing culture in schools to address the challenges of education in today’s society.
Published: 2017

43. Abstract P4-10-09: The impact of Charlson comorbidity index on survival of triple negative breast cancer

Author: Parise, C, primary and Caggiano, V, additional
Published: 2019
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44. Abstract P4-10-04: Assessment of clinical trial participation on breast cancer survival

Author: Parise, C, primary and Caggiano, V, additional
Published: 2019
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45. CANAKINUMAB AS FIRST-LINE BIOLOGICAL THERAPY IN STILL'S DISEASE AND DIFFERENCES BETWEEN THE SYSTEMIC AND THE CHRONICARTICULAR COURSES: REAL-LIFE EXPERIENCE FROM THE INTERNATIONAL AIDA REGISTRY.

Author: Vitale, A., Caggiano, V., Maggio, M. C., Lopalco, G., Emmi, G., Sota, J., La Torre, F., Ruscitti, P., Bartoloni, E., Conti, G., Fabiani, C., Mattioli, I., Gaggiano, C., Cardinale, F., Dagna, L., Campochiaro, C., Giacomelli, R., Balistreri, A., Laskari, K., and Tufan, A.
Published: 2023
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46. EFFICACY AND SAFETY OF ADALIMUMAB IN PEDIATRIC NON-INFECTIOUS NON-ANTERIOR UVEITIS: REAL-LIFE EXPERIENCE FROM AIDA INTERNATIONAL REGISTRY.

Author: Fabiani, C., Vitale, A., Casa, F. Della, Guerriero, S., Ragab, G., Brucato, A., Cattalini, M., Del Giudice, E., Marino, A., Paroli, M. P., Gaggiano, C., Sota, J., Caggiano, V., Tarsia, M., Frediani, B., and Cantarini, L.
Published: 2023
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47. El emprendedor desde el enfoque de la psicología positiva

Author: Sánchez García, José Carlos, Gutiérrez García, Andrea, Carballo, T., Quintana, R., Caggiano, V., Sanchez, J. C, Guierrez, A, Carballo, T, and Caggiano, Valeria
Abstract: In this paper, we expect to analyse the relationship between Positive Psychology and entrepreneur behaviour. Originally and since no some much time ago, psychology only concentrated in the pathology, weakness and suffering. Nowadays the emphasis is on the mental welfare or quality of life, so that the human being could, in addition of living healthy, get stronger in adversity or crisis that could experience. Typical concepts of Positive Psychology as resilience, motivation and happiness, are qualities of the entrepreneur. The entrepreneur has an special feeling to detect opportunities, mobilize resources, link information or has innovative ideas. In short, to find opportunities where other people don´t see it or make thoughts real. Having entrepreneur´s nature is to do things, to get up with more strength when you have fallen and to be optimist living with uncertainty. Therefore, the study of entrepreneur´s behaviour and sucess can´t be understood if we don´t take the point of view of Positive Psychology. En el presente trabajo se pretende analizar la conexión entre la psicología positiva y el comportamiento emprendedor. Desde sus orígenes y hasta hace no tanto tiempo atrás, la psicología sólo se centraba en la patología, en la debilidad y en el sufrimiento. Actualmente, el acento se pone sobre el bienestar mental o la calidad de vida para que el ser humano pueda, además de vivir saludablemente, salir fortalecido ante las adversidades o crisis que puedan presentársele. Conceptos propios de la psicología positiva como son resiliencia, motivación o felicidad, son cualidades propias del emprendedor, el cual tiene una sensibilidad especial para detectar oportunidades, movilizar recursos, interconectar información o tener ideas innovadoras. En definitiva, para hallar oportunidades donde otros no las ven o convertir en hechos lo pensado. Tener espíritu emprendedor es hacer las cosas, levantarse con más fuerza cada vez que se cae y ser capaz de convivir con la incertidumbre manteniéndose optimista. Por consiguiente, el estudio del comportamiento y el éxito emprendedor no puede ser correctamente entendido si no se aborda desde la óptica de la psicología positiva.
Published: 2010

48. Job insecurity, autoefficacia e stress psicologico

Author: Chirumbolo, Antonio, Areni, Alessandra, and Caggiano, V.
Subjects: stress psicologico, salute fisica, analisi di moderazione, Job insecurity, autoefficacia, salute mentale
Published: 2009

49. Anthropic inverse kinematics of robot manipulators in handwriting tasks

Author: DE SANTIS, A., Caggiano, V., Siciliano, B., Villani, L., and Boccignone, Giuseppe
Published: 2005

50. Attentive video analysis using spatial-based and object-based cues

Author: Boccignone, G., Caggiano, V., DI FIORE, G., Napoletano, P., and Marcelli, Angelo
Published: 2005

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