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Catapano, Alberico L, Tokgözoğlu, Lale, Banach, Maciej, Gazzotti, Marta, Olmastroni, Elena, Casula, Manuela, Ray, Kausik K, the Lipid Clinics Network, Alaa ABDELRAZIK (University Hospital of North Midland, United Kingdom), Alberto MELLO E SILVA (Sociedade Portuguesa de Aterosclerose, Portugal), Alexander VONBANK (VIVIT Institute, Austria), Alexandros, D TSELEPIS (Dept of Chemistry, Atherothrombosis Research Center, University of Ioannina, Greece), Alper SONMEZ (Department of Endocrinology and Metabolism, Ankara Guven Hospital, Turkey), Angelina PASSARO (Department of Translational Medicine, University of Ferrara &amp, Center for the Study and Treatment of Metabolic Diseases, Atherosclerosis, and Clinical Nutrition, University Hospital of Ferrara Arcispedale Sant’Anna, Italy), Anja VOGT (Medizinische Klinik und Poliklinik IV, Klinikum der Universit¨at München, Germany), Ann MERTENS (Clinical and Experimental Endocrinology, Leuven, Ku, Leuven, Belgium), Ann VERHAEGEN (Antwerp University Hospital, Belgium), Arman, S POSTADZHIYAN (Medical University of Sofia, Saint Anna University Hospital, Departement of Cardiology, Bulgaria), BAHADIR KIRILMAZ (Canakkale Onsekiz Mart University, Medical Faculty Cardiology Dept, Baris GUNGOR (University of Health Sciences Dr. Siyami Ersek Hospital, Turkey), Berit S HEDEGAARD (Aalborg University, Denmark), Bertrand CARIOU (Nantes Universit´e, Chu, Nantes, Cnrs, Inserm, l’institut du thorax, Nantes, France), Britta OTTE (Universit¨atsklinikum Münster, Lipidambulanz, Germany), Bu˘gra ¨OZKAN (Mersin University, Turkey), of cardiology, Christ BERGE (Dept., Unversity Hopsital, Haukeland., Norway), F EBENBICHLER (Department for Internal Medicine I, Christoph, Medical University Innsbruck, Austria), Christoph J BINDER (Medical University of Vienna, Austria), Christoph OLIVIER (Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Conrad AZZOPARDI (Mater Dei Hospital, Malta), Cristina SOLER (Lipid Unit, Hospital de Sta Caterina, Spain), Dan GAITA (Universitatea de Medicina si Farmacie Victor Babes din Timisoara &amp, Clinica de Cardiologie, Institutul de Boli Cardiovasculare Timisoara, Romania), Daniel WEGHUBER (Department of Pediatrics, Paracelsus Medical University, Dilek URAL (Koç University School of Medicine Department of Cardiology, Turkey), Diogo CRUZ (Hospital de Cascais - Dr. Jos´e de Almeida, Portugal), Dragos VINEREANU (University of Medicine and Pharmacy, University and Emergency Hospital, Bucharest, Romania), Elena D PENCU (Grand Hˆopital de Charleroi GHDC, Belgium), Emil HAGSTR¨OM (Dept of medical sciences, Uppsala, University, Sweden), Erik B SCHMIDT (Aalborg University, Denmark), Erik, S STROES (Dept of vascular medicine, Amsterdamumc, The, Netherlands), Evangelos LIBEROPOULOS (1st Department of Propedeutic Medicine, School of Medicine, National and Kapodistrian University of Athens, General Hospital of Athens Laiko, Fabian DEMEURE (CHU UCL Namur - Site Godinne, Belgium), Fabio FIMIANI (Azienda Ospedaliera di Rilievo Nazionale AORN Dei Colli, Monaldi', 'V., Unit of Inherited and Rare Cardiovascular Diseases, Italy, ), Fabio PELLEGATTA (Center for the Study of Atherosclerosis. Bassini Hospital. Cinisello Balsamo, Italy), Fahri BAYRAM (Erciyes University, Turkey), Finn L HENRIKSEN (Department of Cardiology Odense University Hospital, Denmark), Florian H¨OLLERL (1st Medical Department, Landstrasse, Clinic, Vienna Health Association, Francesco CIPOLLONE (Clinica Medica Institute of, Department of Medicine and Aging Sciences, d’Annunzio' University, 'G., Francisco ARAÚJO (Hospital Lusíadas, Portugal), Franck BOCCARA (Sorbonne Universit´e, Groupe de Recherche Clinique number 22, C2MV—Complications Cardiovasculaires et M´etaboliques chez les Patients Vivant avec le Virus de l’Immunod´eficience Humaine, Institut National de la Sant´e et de la Recherche M´edicale Unit´e Mixte de Recherche, S 938, Centre de Recherche Saint-Antoine, Institut Hospital Universitaire de Cardiom ´etabolisme et Nutrition Cardiologie, Hˆopital Saint Antoine Assistance Publique–Hˆopitaux de Paris, Paris, France), François PAILLARD (Cardiologie et Centre Clinico-Biologique des Lipides et Ath´eroscl´erose, Chu, Rennes, France), Imre University Teaching Hospital, Gabor SIMONYI (DBC St., Metabolic, Center, Lipid, Center, Hungary), Gabriella IANNUZZO (Department of Clinical Medicine and Surgery. University of Naples Federico II, Italy), Giuseppe MANDRAFFINO (Department of Clinical and Experimental Medicine, - Lipid Center, University of Messina, Graham BAYLY (Dept Clinical Biochemistry, University Hospitals Bristol, United, Kingdom), Gustavs LATKOVSKIS (Institute of Cardiology and Regenerative Medicine, University of Latvia &amp, Latvian Center of Cardiology, Pauls Stradins Clinical University Hospital &amp, University of Latvia, Latvia), Gy¨orgy PARAGH (Division of Metabolic Disorders, Department of Internal Medicine, University of Debrecen, Debrecen, Hungary), Hana ROSOLOVA (Charles University Prague Medical Hospital in Pilsen, Czech Republic), Handrean SORAN (Central Manchester University Hospital NHS Foundation Trust, United Kingdom), Helle KANSTRUP (Department of cardiology, Aarhus University hospital, Denmark), Hermann TOPLAK (Department of Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Hülya ÇIÇEKÇIO ˘GLU (ankara bilkent city hospital, Turkey), Inanc ARTAC (Department of Cardiology, Kafkas University Hospital, Ioanna GOUNI-BERTHOLD (Center for Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Irfan, V DUZEN (Gaziantep University, Cardiology, Department, Isabel M PALMA (CHUPORTO - Centro Hospitalar Universit ´ario do Porto, Portugal), Istvan REIBER (Szent Gyorgy University Teaching Hospital of Fejer County, Hungary), Iveta DZIVITE-KRISANE (Children’s University Hospital, Latvia), Jeanine, E ROETERS VAN LENNEP (Department of Internal medicine, Erasmus MC University Medical Center, Jean-Luc, J BALLIGAND (Institut de Recherche Exp´erimentale et Clinique, Universite catholique de Louvain, Bruxelles), Joao C PORTO (CHUC, Portugal), Jo˜ao, S DUARTE (Hospital Egas Moniz, Lisboa, Portugal), Johan DE SUTTER (AZ Maria Middelares Hospital Gent, Belgium), Jos´e L´OPEZ-MIRANDA (Lipid and Arteriosclerosis Unit. Department of Internal Medicine. Hospital Universitario Reina Sofia. IMIBIC. University of Cordoba. CiberOBN, Spain), Jose M MOSTAZA (Hospital La Paz-Carlos III, Spain), Jurgita PLISIENE (Lithuanian University of Health sciences, Lithuania), Kadir, U MERT (Eskis ¸ehir Osmangazi University, Department of Cardiology, Kirsten, B HOLVEN (Department of Nutrition, University of Oslo and National Advisory unit on FH, Oslo University Hospital, Kjetil RETTERSTØL (The Lipid Clinic, Oslo University Hospital and Department of Nutrition, University of Oslo, Kristian, K THOMSEN (University Hospital of South Denmark, Esbjerg, Denmark), Lale TOKGOZOGLU (Hacettepe University, Turkey), Laszlo BAJNOK (1st Department of Medicine, Medical, School, University of Pecs, Lia E BANG (Copenhagen University Hospital, Denmark), Liliana GRIGORE (IRCCS Multimedica, Italy), Lluís MASANA (Hospital Universitari Sant Joan. Universitat Rovira i Virgili. CIBERDEM. Reus, Spain), Loukianos S RALLIDIS (University General Hospital Attikon, Greece), Maciej BANACH (Department of Preventive Cardiology and Lipidology, Medical University of Lodz, Poland), Małgorzata WALU´S-MIARKA (Jagiellonian University Medical College, Of Metabolic Diseases and Diabetology, Dept., Manuel CASTRO CABEZAS (Franciscus Gasthuis &amp, Vlietland Rotterdam, The Netherlands), Marcello ARCA (Sapienza University of Rome, Italy), Margus VIIGIMAA (North Estonia Medical Centre, Tallinn University of Technology, Estonia), Martin, P BOGSRUD (Unit for Cardiac and Cardiovascular Genetics, Matej MLINARIˇC (Department of Endocrinology, Diabetes and Metabolism, University Children’s Hospital, University Medical Centre Ljubljana, Slovenia), Matteo PIRRO (Section of Internal Medicine, Angiology and Arteriosclerosis Diseases, Maurizio AVERNA (Department PROMISE-University of Palermo &amp, Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Palermo, Italy), Meral KAYIKCIOGLU (Ege University Medical School Department of Cardiology, Turkey), Merete HEITMANN (Bispebjerg-Frederiksberg University Hospital, Denmark), Mette MOURIDSEN (Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Michal VRABLIK (3rd Department of Internal Medicine, General University Hospital and 1st Medical Faculty, Charles, University, Prague, Czech, Republic), Michel FARNIER (PEC2, University of Bourgogne Franche-Comt´e, Laboratory Medicine, Michel R LANGLOIS (Dept., Jan Hospital, AZ St., Belgium), Milad KHEDR (Department of Clinical Biochemistry and Metabolic Medicine, Royal Liverpool University Hospital, Muge ILDIZLI DEMIRBAS (Kartal Kosuyolu Research and Training Hospital, Turkey), Myra TILNEY (Lipid Clinic, Mater Dei Hospital &amp, Dept of Medicine, University of Malta Medical School, Malta), Nadia CITRONI (Internal Medicine, APSS Trento Hospital, Of Internal Medicine, Niels P RIKSEN (Dept., Radboud university medical center, Nikolay M RUNEV (UMHAT Alexandrovska, Bulgaria), Nora KUPSTYTEKRISTAPONE (Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Lithuania), Olena MITCHENKO (NSC, Clinical and Regenerative Medicine of the NAMS of Ukraine, Ukraine), Oliver WEING¨ARTNER (Universit¨atsklinikum Jena, Department of Internal Medicine, I, Oner OZDOGAN (University of Health Sciences, Izmir Faculty of Medicine, Tepecik Training and Research Hospital, Ovidio MU˜NIZGRIJALVO (Hospital Virgen del Rocío, Spain), Ozcan BASARAN (Mugla Sitki Kocman University, Pankaj GUPTA (University Hospitals of Leicester, United Kingdom), Paolo PARINI (Cardio Metabolic Unit, Karolinska, Institutet, and Theme Inflammation and Ageing, Karolinska University Hospital Huddinge, Patrizia SUPPRESSA (Department of Internal Medicine and rare disease Centre, Bari, Italy), Paul DOWNIE (Salisbury NHS Foundation trust, United Kingdom), Pavel JESINA (Metabolic Center General University Hospital, Czech Republic), of Internal Medicine, Pavel KRAML (Dept., Third Faculty of Medicine, Charles University and Kr´alovsk´e Vinohrady University Hospital Prague, Pawel BURCHARDT (Department of Cardiology, Cardiovascular, Unit, Hospital, J. Stru´s., Pozna´n, &amp, Department of Hypertension, Angiology and Internal Medicine, Poznan University of Medical Sciences, Pozna´n, Poland), Pedro VALDIVIELSO (Hospital VIRGEN DE LA VICTORIA, Spain), Pedro VON HAFE (Instituto Cuf, Portugal), Dept, Peter FASCHING (5th Med., Clinic, Ottakring, Philippe MOULIN (Hospices civils de Lyon/INSERM/Universit ´e Lyon1, Hˆopital Louis Pradel, F´ed´eration, D’Endocrinologie, Quit´eria RATO (Sociedade Portuguesa de Aterosclerose, Portugal), Reinhold INNERHOFER (Medical University Vienna, Austria), Renata C´IFKOV´A (Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer University Hospital, Rene VALERO (Aix Marseille Univ, Aphm, Inserm, Inrae, C2vn, University Hospital La Conception, Department of Nutrition, Metabolic Diseases and Endocrinology, Scicali, Roberto, Robin URB´ANEK (Internal medicine, Obezita-Ormiga, s. r. o., Roma KAVALIAUSKIENE (Klaip˙ eda Seamen’s Hospital, Lituania), Roman CIBULKA (Department of paramedic science, medical diagnostics studies and public health, Faculty of Health Care Studies, University of West Bohemia, Sabina ZAMBON (Department of Medicine, - DIMED, University of Padova, Sergio D’ADDATO (University of Bologna. IRCCS S. Orsola Bologna, Italy), Stanislav ZEMEK (Lipidova ambulance, Czech Republic), Stefano ROMEO (Gothenburg University, Sweden), Stephanie K¨ONEMANN (Department of Internal Medicine, B, University Medicine Greifswald, DZHK (German Centre for Cardiovascular Research), Susanne GREBER-PLATZER (Clinical Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Thomas STULNIG (Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna &amp, Third Medical Department and Karl Landsteiner Institute for Metabolic Diseases and Nephrology, Clinic, Hietzing, Vienna, Austria), Thomas MUHR (Dept of Cardiology, Link¨oping University Hospital, Tina, Z KHAN (Consultant Cardiologist, Royal Brompton and Harefield Hospitals Part of Guy’s and St Thomas’ NHS Foundation Trust, Tomas FREIBERGER (Centre of Cardiovascular Surgery and Transplantation, Brno &amp, Medical, Faculty, Masaryk, University, Brno, Tom´aˇs ˇS´ALEK (Metabolic Clinic, Tomas Bata Hospital, Zlín, Tomas VASYLIUS (Republican Panevezys hospital, Of Cardiology, Dep., Lithuania), Ulrich LAUFS (Klinik und Poliklinik für Kardiologie, Universit ¨atsklinikum Leipzig, Ulrike SCHATZ (University Hospital Carl Gustav Carus Dresden at the Technical University Dresden, Department of Internal Medicine III, Urh GROSELJ (UMC, - University Children’s Hospital Ljubljana, University of Ljubljana, Victoria MARCO-BENEDI (Hospital Universitario Miguel Servet, Iisa, Cibercv, Vincent MAHER (Advanced Lipid Management and Research ALMAR centre, Tallaght University Hospital, Ireland), Vladimír BLAHA (University Hospital Hradec Kr´alov´e and Charles University, Faculty of Medicine in Hradec Kr´alov´e, 3rd Department of Internal Medicine, - Metabolism and Gerontology, Vladimir SOSKA (Department of Clinical Biochemistry, St. Anne’s University Hospital Brno, 2nd Clinic of Internal Medicine, Masaryk University Brno, Volker JJ SCHETTLER (Centre of Nephrology G¨ottingen, Germany), Wolfgang REINHARDT (SUS Malmoe, Sweden), Xavier PINT´O (Hospital Universitari de Bellvitge-Idibell-UB-CiberObn, Spain), Yoto YOTOV (Second Cardiology Clinic, Marina, University Hospital Sv., Medical University of Varna, Zaneta PETRULIONIENE (Vilnius University Medical Faculty, Vilnius University Hospital Santaros klinikos, Lithuania), ˇZeljko REINER (Department for Metabolic Diseases, University Hospital Center Zagreb, and Croatia, ).

Ana Alcaraz-Serna, Centro Nacional de Investigaciones Cardiovasculares (Cnic), Madrid, Spain., Enrique Vázquez, Ester Marina-Zárate, Juliana Barreto de Alburquerque, Jens V. Stein, Erika Lorenzo-Vivas, Fátima Sánchez-Cabo, Manuel Gómez, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Cibercv), Francisco Sánchez-Madrid, Diego Calzada-Fraile, Irene Fernández-Delgado, Ana Dopazo, Nora Ruef, Daniel Torralba, Eugenio Bustos-Morán, and Almudena R. Ramiro

Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Cibercv), Sebastián Cerdán, Ignacio Prieto, Mª Begoña Ruiz-Larrea, R. Manuel Portero, Antonio Martínez-Ruiz, José Ignacio Ruiz-Sanz, Raquel García-Gómez, Carmen Rubio-Alarcón, n. Leioa (Spain)., Rebeca Berdún, Reinald Pamplona, María Monsalve, Mariona Jové, and Euskal Herriko Unibertsitea. Barrio Sarriena s

Ayelén M Santamans, Elisa Manieri, Eric N. Jimenez Vazquez, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (Cibercv), Madrid, Spain., María del Valle Montalvo, Bárbara González-Terán, Rafael Romero-Becerra, José Jalife, Luis Leiva-Vega, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos Iii, Madrid, Spain., María Elena Rodríguez, Guadalupe Sabio, Luis Jesús Jiménez Borreguero, Ivana Nikolic, Laura Sanz, Víctor Buendía, Roberto Ramos Mondragon, Guadalupe Guerrero Serna, Daniela Ponce-Balbuena, and David Filgueiras

F. Gómez Peña, Cibercv, A. Avila Carrillo, J R Gonzalez Juanatey, X. Sanmartin Pena, B Alvarez Alvarez, D Lopez Otero, A. Redondo Dieguez, B Cid Alvarez, and R. Trillo Nouche

Dpt. Farmacología, Facultad de Medicina, Uam. IdiPAZ. Madrid, Spain., Constanza Ballesteros, María González Amor, Mercedes Salaices, Ana M. Briones, Ana B. García Redondo, Spain. Ciber de enfermedades cardiovasculares (CiberCV), Luis M. Beltrán, and Raquel Rodrígues Díez

Gimeno, Juan R., Olivotto, Iacopo, Isabel Rodriguez, Ana, Ho, Carolyn Y., Fernandez, Adrian, Quiroga, Alejandro, Angeles Espinosa, Mari, Gomez-Gonzalez, Cristina, Robledo, Maria, Tojal-Sierra, Lucas, Day, Sharlene M., Owens, Anjali, Barriales-Villa, Roberto, Maria Larranaga, Jose, Rodriguez-Palomares, Jose, Gonzalez-del-Hoyo, Maribel, Piqueras-Flores, Jesus, Reza, Nosheen, Chumakova, Olga, Ashley, Euan A., Parikh, Victoria, Wheeler, Matthew, Jacoby, Daniel, Pereira, Alexandre C., Saberi, Sara, Helms, Adam S., Villacorta, Eduardo, Gallego-Delgado, Maria, Castro, Daniel, Dominguez, Fernando, Ripoll-Vera, Tomas, Zorio-Grima, Esther, Carlos Sanchez-Martinez, Jose, Garcia-Alvarez, Ana, Arbelo, Elena, Victoria Mogollon, Maria, Eugenia Fuentes-Canamero, Maria, Grande, Elias, Pena, Carlos, Monserrat, Lorenzo, Lakdawala, Neal K., Dilema Int Cardiomyopathy Heart Fa, [Gimeno, Juan R.] Univ Murcia, Dept Med Interns, Ctra Finca Buenavista S-N,Campus Ciencias Salud, Murcia 30120, Spain, [Isabel Rodriguez, Ana] Univ Murcia, Dept Med Interns, Ctra Finca Buenavista S-N,Campus Ciencias Salud, Murcia 30120, Spain, [Gimeno, Juan R.] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Isabel Rodriguez, Ana] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Castro, Daniel] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Dominguez, Fernando] European Reference Networks Rare Low Prevalence &, Amsterdam, Netherlands, [Gimeno, Juan R.] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Angeles Espinosa, Mari] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gomez-Gonzalez, Cristina] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Barriales-Villa, Roberto] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Maria Larranaga, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Rodriguez-Palomares, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gonzalez-del-Hoyo, Maribel] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Villacorta, Eduardo] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Gallego-Delgado, Maria] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Castro, Daniel] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Dominguez, Fernando] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Zorio-Grima, Esther] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Carlos Sanchez-Martinez, Jose] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Garcia-Alvarez, Ana] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Arbelo, Elena] Ctr Biomed Network Res Cardiovasc Dis CIBERCV, Madrid, Spain, [Olivotto, Iacopo] Careggi Univ Hosp, Cardiomyopathy Unit, Florence, Italy, [Ho, Carolyn Y.] Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA, [Lakdawala, Neal K.] Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA, [Fernandez, Adrian] Favaloro Fdn Univ Hosp, Unidad Cardiopatias Familiares, Buenos Aires, DF, Argentina, [Quiroga, Alejandro] Favaloro Fdn Univ Hosp, Unidad Cardiopatias Familiares, Buenos Aires, DF, Argentina, [Angeles Espinosa, Mari] Hosp Gen Univ Gregorio Maranon, Unidad Cardiopatias Familiares, Madrid, Spain, [Gomez-Gonzalez, Cristina] Hosp Gen Univ Gregorio Maranon, Unidad Cardiopatias Familiares, Madrid, Spain, [Robledo, Maria] Hosp Univ Araba Txagorritxu, Alava, Spain, [Tojal-Sierra, Lucas] Hosp Univ Araba Txagorritxu, Alava, Spain, [Day, Sharlene M.] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Owens, Anjali] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Reza, Nosheen] Hosp Univ Penn, Dept Med, Philadelphia, PA 19104 USA, [Barriales-Villa, Roberto] Complexo Hosp Univ A Coruna, Unidad CSUR Cardiopatias Familiares, La Coruna, Spain, [Maria Larranaga, Jose] Complexo Hosp Univ A Coruna, Unidad CSUR Cardiopatias Familiares, La Coruna, Spain, [Rodriguez-Palomares, Jose] Hosp Univ Vall dHebron, Dept Cardiol, Barcelona, Spain, [Gonzalez-del-Hoyo, Maribel] Hosp Univ Vall dHebron, Dept Cardiol, Barcelona, Spain, [Rodriguez-Palomares, Jose] Univ Autonoma Barcelona, Vall dHebron Inst Recerca VHIR, Barcelona, Spain, [Gonzalez-del-Hoyo, Maribel] Univ Autonoma Barcelona, Vall dHebron Inst Recerca VHIR, Barcelona, Spain, [Piqueras-Flores, Jesus] Hosp Gen Univ Ciudad Real, Cardiac Dept, Ciudad Real, Spain, [Chumakova, Olga] Municipal Clin Hosp 17, Moscow, Russia, [Ashley, Euan A.] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Parikh, Victoria] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Wheeler, Matthew] Stanford Univ, Med Ctr, Ctr Inherited Heart Dis, Stanford, CA 94305 USA, [Jacoby, Daniel] Yale New Haven Hosp, New Haven, CT USA, [Pereira, Alexandre C.] Univ Sao Paulo, Hosp Clin, Sao Paulo, Brazil, [Saberi, Sara] Univ Michigan Hosp, Dept Internal Med, Ann Arbor, MI 48109 USA, [Helms, Adam S.] Univ Michigan Hosp, Dept Internal Med, Ann Arbor, MI 48109 USA, [Villacorta, Eduardo] Complejo Asistencial Univ Salamanca, Serv Cardiol, Unidad Cardiopatias Familiares, Salamanca, Spain, [Gallego-Delgado, Maria] Complejo Asistencial Univ Salamanca, Serv Cardiol, Unidad Cardiopatias Familiares, Salamanca, Spain, [Villacorta, Eduardo] Inst Invest Biomed Salamanca IBSAL, Gerencia Reg Salud Castilla & Leon SACYL, Salamanca, Spain, [Gallego-Delgado, Maria] Inst Invest Biomed Salamanca IBSAL, Gerencia Reg Salud Castilla & Leon SACYL, Salamanca, Spain, [Villacorta, Eduardo] Univ Salamanca, Dept Med, Salamanca, Spain, [Gallego-Delgado, Maria] Univ Salamanca, Dept Med, Salamanca, Spain, [Castro, Daniel] Hosp Univ Puerta Hierro Majadahonda, Unidad CSUR ERN Cardiopatias Familiares, Madrid, Spain, [Dominguez, Fernando] Hosp Univ Puerta Hierro Majadahonda, Unidad CSUR ERN Cardiopatias Familiares, Madrid, Spain, [Ripoll-Vera, Tomas] Hosp Univ Son Llatzer, Unidad Cardiopatias Familiares, Mallorca, Spain, [Zorio-Grima, Esther] Hosp Univ & Politecn La Fe, Unidad Cardiopatias Familiares, Valencia, Spain, [Carlos Sanchez-Martinez, Jose] Hosp Univ & Politecn La Fe, Unidad Cardiopatias Familiares, Valencia, Spain, [Garcia-Alvarez, Ana] Univ Barcelona, Hosp Clin, Cardiol Dept, Arrhythmia Sect, Barcelona, Spain, [Arbelo, Elena] Univ Barcelona, Hosp Clin, Cardiol Dept, Arrhythmia Sect, Barcelona, Spain, [Garcia-Alvarez, Ana] Inst Invest August Pi & Sunyer IDIBAPS, Barcelona, Spain, [Arbelo, Elena] Inst Invest August Pi & Sunyer IDIBAPS, Barcelona, Spain, [Victoria Mogollon, Maria] Hosp San Pedro Alcantara, Cardiac Dept, Caceres, Spain, [Eugenia Fuentes-Canamero, Maria] Badajoz Univ Hosp, Cardiac Dept, Badajoz, Spain, [Grande, Elias] Dilemma Solut SL, La Coruna, Spain, [Pena, Carlos] Dilemma Solut SL, La Coruna, Spain, [Monserrat, Lorenzo] Dilemma Solut SL, La Coruna, SpainHosp Univ Virgen de la Victoria, Unidad Insuficiencia Cardiaca & Cardiopatias Fami, Serv Cardiol, Malaga, SpainHosp Vega Baja, Cardiac Dept, Alicante, SpainHosp Univ Virgen del Rocio, Unidad Cardiopatias Familiares, Seville, SpainUniv Trieste, Azienda Sanitaria Univ Giuliano Isontina ASUGI, Cardiothoracovasc Dept, Trieste, ItalyHosp Univ Infanta Leonor, Cardiac Dept, Madrid, SpainHosp Gen Univ Alicante, Unidad Cardiopatias Familiares, Alicante, SpainHosp Arquitecto Morcide, Cardiac Dept, Ferrol, Spain, Instituto de Salud Carlos III (ICSIII), MyoKardia/Bristol Myers Squibb, Institut Català de la Salut, [Gimeno JR] Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain. European Reference Networks for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart), Amsterdam, The Netherlands. Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Olivotto I] Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy. [Rodríguez AI] Departamento de Medicina Interna, Universidad de Murcia, Murcia, Spain. European Reference Networks for rare, low prevalence and complex diseases of the heart (ERN GUARD-Heart), Amsterdam, The Netherlands. [Ho CY] Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA. [Fernández A, Quiroga A] Unidad de Cardiopatías Familiares, Favaloro Foundation University Hospital, Buenos Aires, Argentina. [Rodríguez-Palomares J, González-del-Hoyo M] Center for Biomedical Network Research on Cardiovascular Diseases (CIBERCV), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Marta Consegal, Ignasi Barba, Bruno García del Blanco, Imanol Otaegui, José F. Rodríguez-Palomares, Gerard Martí, Bernat Serra, Neus Bellera, Manuel Ojeda-Ramos, Filipa Valente, Maria Ángeles Carmona, Elisabet Miró-Casas, Antonia Sambola, Rosa María Lidón, Jordi Bañeras, José Antonio Barrabés, Cristina Rodríguez, Begoña Benito, Marisol Ruiz-Meana, Javier Inserte, Ignacio Ferreira-González, Antonio Rodríguez-Sinovas, Institut Català de la Salut, [Consegal M, Benito B, Ruiz-Meana M, Inserte J, Rodríguez-Sinovas A] Grup de Recerca de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. [Barba I] Grup de Recerca de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. Faculty of Medicine, University of Vic - Central University of Catalonia (UVicUCC), Vic, Spain. [García Del Blanco B, Otaegui I, Rodríguez-Palomares JF, Martí G, Serra B, Bellera N, Ojeda-Ramos M, Valente F, Carmona MÁ, Miró-Casas E, Sambola A, Lidón RM, Bañeras J, Barrabés JA] Grup de Recerca de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain. [Ferreira-González I] Grup de Recerca de Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Epidemiología y Salud Pública, CIBERESP, Instituto de Salud Carlos III, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Maria Antonia Pijuan-Domènech, Silvia Montserrat, Victor Pineda, Filipa Valente, Ignacio Ferreira-Gonzalez, Josep-Ramon Marsal, Miguel Angel Castro-Alba, Carlos Sureda-Barbosa, Berta Miranda-Barrio, Maria Teresa Subirana-Domènech, Laura Dos-Subirà, Jaume Casaldàliga-Ferrer, Institut Català de la Salut, [Pijuan-Domènech MA, Miranda-Barrio B, Dos-Subirà L] Unitat Integrada de Cardiopaties Congènites de l’Adolescent i l’Adult, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Hospital Sant Pau, Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. [Montserrat S] Department of Cardiology, Cardiovascular Institute, Hospital Clinic Barcelona, Spain. [Pineda V] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Valente F] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Spain. [Ferreira-Gonzalez I] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación en Red de Epidemiología CIBER-ESP, Spain. [Marsal JR] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Castro-Alba MA, Sureda-Barbosa C] Servei de Cirurgia Cardíaca, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Subirana-Domènech MT] Unitat Integrada de Cardiopaties Congènites de l’Adolescent i l’Adult, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Hospital Sant Pau, Barcelona, Spain. Department of Cardiology, Hospital Universitari Santa Creu I Sant Pau, Barcelona, Spain. [Casaldàliga-Ferrer J] Unitat Integrada de Cardiopaties Congènites de l’Adolescent i l’Adult, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Hospital Sant Pau, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

González-Juanatey, Carlos, Anguita-Sánchez, Manuel, Barrios, Vivencio, Núñez-Gil, Iván, Gómez-Doblas, Juan José, García-Moll, Xavier, Lafuente-Gormaz, Carlos, Rollán-Gómez, María Jesús, Peral-Disdier, Vicente, Martínez-Dolz, Luis, Rodríguez-Santamarta, Miguel, Viñolas-Prat, Xavier, Soriano-Colomé, Toni, Muñoz-Aguilera, Roberto, Plaza, Ignacio, Curcio-Ruigómez, Alejandro, Orts-Soler, Ernesto, Segovia, Javier, Fanjul, Víctor, Cequier, Ángel, Savana Research Group, Institut Català de la Salut, [González-Juanatey C] Hospital Universitario Lucus Augusti, Lugo, Spain. [Anguita-Sánchez M] Hospital Universitario Reina Sofía, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba, Spain. [Barrios V] Hospital Universitario Ramón y Cajal, Madrid, Spain. [Núñez-Gil I] Hospital Clínico Universitario San Carlos, Madrid, Spain. [Gómez-Doblas JJ] Hospital Universitario Virgen de la Victoria CIBERCV (Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares) and IBIMA (Instituto de Investigación Biomédica de Málaga), Málaga, Spain. [García-Moll X] Hospital Universitario Santa Creu i Sant Pau, Barcelona, Spain. [Soriano-Colomé T] Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Guler, Melisa N., Tscheiller, Nathalie M., Sabater-Molina, M. (Maria), Gimeno, Juan R., Nebigil-Désaubry, C. (Canan), Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares [Spain] (CIBERCV), univOAK, Archive ouverte, Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), and NEBIGIL Desaubry, Canan

Evangelista Masip, Arturo, Galian-Gay, Laura, Guala, Andrea, Lopez-Sainz, Angela, Teixido-Turà, Gisela, Ruiz Muñoz, Aroa, Valente, Filipa, Gutierrez, Laura, Fernandez-Galera, Ruben, Casas, Guillem, Panaro, Alejandro, Marigliano, Alba, Huguet, Marina, González-Alujas, Teresa, Rodríguez-Palomares, José F., Universitat Autònoma de Barcelona, Institut Català de la Salut, [Evangelista Masip A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Teknon Heart Institute-Quiron Salud, Barcelona, Spain. [Galian-Gay L, Guala A, Lopez-Sainz A, Teixido-Turà G, Ruiz Muñoz A, Valente F, Gutierrez L, Fernandez-Galera R, Casas G, González-Alujas T, Rodriguez-Palomares J] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Claudia Álvarez-Martín, Aida Ribera, Josep Ramon Marsal, Albert Ariza-Solé, Santiago Pérez-Hoyos, Gerard Oristrell, Toni Soriano-Colomé, Rafael Romaguera, Jose Ignacio Pijoan, Rosa M. Lidón, Josepa Mauri, Ignacio Ferreira-González, Institut Català de la Salut, [Álvarez-Martín C, Marsal JR] Unitat de Recerca Cardiovascular i Epidemiologia, Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Ribera A] Unitat de Recerca Cardiovascular i Epidemiologia, Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Recerca en Envelliment, Fragilitat i Transicions (REFiT) Barcelona Research Group, Parc Sanitari Pere Virgili and Vall d’Hebron Institute of Research, Barcelona, Spain. [Ariza-Solé A] Cardiology Department, Hospital Universitari de Bellvitge, Barcelona, Spain. Bioheart, Grup de Malalties Cardiovasculars, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain. Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Pérez-Hoyos S] Unitat d'Estadística i Bioinformàtica (UEB), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Statistics Department, Faculty of Biology, University of Barcelona, Barcelona, Spain. [Oristrell G, Lidón RM] Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Soriano-Colomé T] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ferreira-González I] Unitat de Recerca Cardiovascular i Epidemiologia, Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

José Rodríguez-Palomares, Sergio Moral, María Celeste Carrero, Laura Galian, Rodolfo Citro, Laura Gutierrez, Josep M. Alegret, Ilaria Dentamaro, Arturo Evangelista, Francisco Calvo, Antonella Moreo, Violeta Sánchez, Paolo Colonna, Augusto Sao-Aviles, Gisela Teixido-Tura, Angela Lopez, Eduardo Bossone, Fabio Chirillo, Institut Català de la Salut, [Lopez A, Dentamaro I, Galian L, Sao-Aviles A, Gutiérrez L, Teixido-Tura G, Rodríguez-Palomares J] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. [Calvo F] Cardiology Department, Hospital Alvaro Cunqueiro, Vigo, Spain. [Alegret JM] Cardiology Department, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Reus, Spain. [Sanchez V] Cardiology Department, University Hospital 12 de Octubre, Madrid, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. Heart Institute, Teknon Medical Center-Quirón Salud, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Lopez, A., Dentamaro, I., Galian, L., Calvo, F., Alegret, J. M., Sanchez, V., Citro, R., Moreo, A., Chirillo, F., Colonna, P., Carrero, M. C., Bossone, E., Moral, S., Sao-Aviles, A., Gutierrez, L., Teixido-Tura, G., Rodriguez-Palomares, J., and Evangelista, A.

Ignacio Ferreira, Laura Galian-Gay, Maria Luz Servato, Gisela Teixido-Tura, Laura Gutierrez, Rubén Fernández-Galera, Filipa Valente, Guillem Casas, Anna Sabaté-Rotés, Arturo Evangelista, Ángela López-Sainz, M. Teresa González-Alujas, José Rodríguez-Palomares, Augusto Sao-Aviles, Institut Català de la Salut, [Servato ML, Teixidó-Turá G, Galian-Gay L, Gutiérrez L, Valente F, Fernandez-Galera R, Casas G, López-Sainz A, González-Alujas MT, Sao-Aviles A, Ferreira I, Rodríguez-Palomares J] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. [Sabate-Rotes A] Servei de Cardiologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. [Evangelista A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERCV, Barcelona, Spain. Teknon Medical Center-Quirón Salud, Heart Institute, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Gonzalo Luis Alonso Salinas, Sergio Raposeiras-Roubín, Alberto Cordero, Francisco Marcos Marín, Pablo Díez-Villanueva, Manuel Martínez-Sellés, Eduardo Núñez, Alfredo Bardají, Albert Ariza-Solé, Nuria Vicente-Ibarra, Juan M. Ruiz-Nodar, Juan Sanchis, Belén Cid-Álvarez, José María García-Acuña, Julio Núñez, Emad Abu Assi, F Formiga, José A. Barrabés, Institut Català de la Salut, [Díez-Villanueva P] Servicio de Cardiología, Hospital Universitario La Princesa, Madrid, Spain. [García-Acuña JM] Servicio de Cardiología, Hospital Clínico Universitario de Santiago, CIBERCV, Santiago de Compostela, A Coruña, Spain. [Raposeiras-Roubin S] Servicio de Cardiología, Hospital Álvaro Cunqueiro de Vigo, Vigo, Pontevedra, Spain. [Barrabés JA] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERCV, Barcelona, Spain. [Cordero A] Servicio de Cardiología, Hospital Clínico Universitario de San Juan, Alicante, Spain. [Martínez-Sellés M] Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Universidad Europea, Universidad Complutense, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Albert Roque, María N Pizzi, Nuria Fernández-Hidalgo, Guillermo Romero-Farina, Gemma Burcet, José Luis Reyes-Juarez, Carina Espinet, Joan Castell-Conesa, Manuel Escobar, Ignacio Ferreira-González, Santiago Aguadé-Bruix, Hug Cuellar-Calabria, Institut Català de la Salut, [Roque A, Burcet G, Reyes-Juarez JL, Cuellar-Calabria H] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. IDI (Institut de Diagnòstic per la Imatge), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Pizzi MN] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomedica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Fernández-Hidalgo N] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Romero-Farina G] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Espinet C, Castell-Conesa J] IDI (Institut de Diagnòstic per la Imatge), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Escobar M] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. IDI (Institut de Diagnòstic per la Imatge), Barcelona, Spain. [Ferreira-González I] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBER de Epidemiologıa y Salud Pública (CIBERESP), Madrid, Spain. [Aguadé-Bruix S] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomedica en Red en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Servei de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Judith Bouchardy, Berto J. Bouma, Pastora Gallego, Harald Gabriel, Daniel Tobler, Laura Dos, Joaquín Rueda Soriano, Matthias Greutmann, Markus Schwerzmann, Magalie Ladouceur, Francisco Javier Ruperti-Repilado, Cardiology, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis, [Ruperti-Repilado, Francisco Javier] Univ Bern, Univ Hosp, Ctr Congenital Heart Dis, Inselspital,Cardiol, Bern, Switzerland, [Schwerzmann, Markus] Univ Bern, Univ Hosp, Ctr Congenital Heart Dis, Inselspital,Cardiol, Bern, Switzerland, [Ladouceur, Magalie] Univ Paris, Hop Europeen Georges Pompidou, AP HP,Adult Congenital Heart Dis Unit,M3C Inserm, Paris Ctr Rech Cardiovasc,Ctr Reference Malformat, Paris, France, [Gallego, Pastora] Hosp Univ Virgen del Rocio, Adult Congenital Heart Dis Unit, Dept Cardiol, Inst BioMed Sevilla, Seville, Spain, [Gallego, Pastora] CIBERCV, Seville, Spain, [Dos, Laura] Hosp Univ Vall dHebron, Unitat Cardiopaties Congenites Adolescent & Adult, Barcelona, Spain, [Rueda Soriano, Joaquin] Hosp Univ & Politecn La Fe, Adult Congenital Heart Dis Unit, Dept Cardiol, Valencia, Spain, [Rueda Soriano, Joaquin] CIBERCV, Valencia, Spain, [Bouma, Berto] Acad Med Ctr, Dept Cardiol, Amsterdam, Netherlands, [Gabriel, Harald] Med Univ Vienna, Dept Cardiol, Adult Congenital Heart Dis Program, Vienna, Austria, [Bouchardy, Judith] Univ Hosp Lausanne, Dept Cardiol & Cardiac Surg, Lausanne, Switzerland, [Bouchardy, Judith] Univ Hosp Geneva, Div Cardiol, Geneva, Switzerland, [Tobler, Daniel] Univ Basel, Univ Hosp Basel, Div Cardiol, Basel, Switzerland, [Greutmann, Matthias] Univ Zurich, Univ Heart Ctr, Dept Cardiol, Zurich, Switzerland, and EPOCH-ASO

Sandra Díaz del Moral, Silvia Barrena, Francisco Hernández-Torres, Amelia Aránega, José Manuel Villaescusa, Juan José Gómez Doblas, Diego Franco, Manuel Jiménez-Navarro, Ramón Muñoz-Chápuli, Rita Carmona, [Díaz del Moral,S, Barrena,S, Muñoz-Chápuli,R, Carmona,R] Department of Animal Biology, University of Málaga, Málaga, Spain. [Hernández-Torres,F] Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. [Hernández-Torres,F, Aránega,A] Medina Foundation, Technology Park of Health Sciences, Granada, Spain. [Aránega,A, Franco,D] Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain. [Villaescusa,JM, Gómez Doblas,JJ, Jiménez-Navarro,M] Heart Area Clinical Management Unit, University Hospìtal Virgen de la Victoria, CIBERCV Enfermedades Cardiovasculares Health Institute Carlos III, Biomedical Research Institute of Malaga (IBIMA), University of Málaga, Málaga, Spain., and This work was supported by: Spanish Ministry of Economy, Industry and Competitivity (BFU2017-83907-P to RM-C and RC and PID2019-107492GB-I00 to AA and DF), Consejería de Salud, Junta de Andalucía (PC0066?2017/PC-0081-2017 to RC, JV, and JG), Instituto de Salud Carlos III-TERCEL network (RD16/0011/0030 to RM-C and RC), Instituto de Salud Carlos III-CIBERCV 'Enfermedades Cardiovasculares' (CB16/11/00360 to MJ-N), and Consejería de Economía yConocimiento, Junta de Andalucía (UMA18-FEDERJA-146 to RM-C and RC and FEDER-UJA to AA and DF).

Melania Guerrero-Hue, Valérie Metzinger-Le Meuth, Eya Hamza, Cristina García-Caballero, Sandra Rayego-Mateos, Juan Antonio Moreno, Laurent Metzinger, Mercedes Vallejo-Mudarra, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), [Moreno,JA, Guerrero-Hue,M, García-Caballero,C, Vallejo-Mudarra,M] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofía, Córdoba, Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain. [Hamza,E, Metzinger,L, Metzinger-Le Meuth,V] HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne (UPJV), CEDEX 1, Amiens, France. [Rayego-Mateos,S] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Metzinger-Le Meuth,V] INSERM UMRS 1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, Université Sorbonne Paris Nord, CEDEX, Bobigny, France., This research was funded by SFNDT, Vifor. (L.M., V.M.-L.M. and E.H.), Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130 and PI20/00375), Spanish Biomedical Research Centre in Cardiovascular Diseases (CIBERCV), Spanish Ministry of Science and Innovation (RYC-2017-22369), and Spanish Society of Nephrology (SEN). The 'PFIS' and 'Sara Borrell' training program of the ISCIII supported the salary of MGH (FI18/00310) and SR-M (CD19/00021)., Hospital Universitario Reina Sofia [Cordoue, Espagne], Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares [Spain] (CIBERCV), Universidad de Córdoba = University of Córdoba [Córdoba], HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Autónoma de Madrid (UAM), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, UFR Santé, Médecine et Biologie Humaine (UFR SMBH), Université Sorbonne Paris Nord, and DESSAIVRE, Louise

Begoña Benito, Marisol Ruiz-Meana, Javier Inserte, Norberto Núñez, Marta Consegal, Ignacio Ferreira-González, Antonio Rodríguez-Sinovas, Ignasi Barba, Institut Català de la Salut, [Consegal M, Benito B, Ruiz-Meana M, Inserte J, Rodríguez-Sinovas A] Grup de Recerca en Malalties Cardiovasculars, Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. [Núñez N] Unitat d'Alta Tecnologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Barba I] Grup de Recerca en Malalties Cardiovasculars, Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. Faculty of Medicine, University of Vic-Central University of Catalonia (UVicUCC), Can Baumann. Ctra. de Roda, 70, 08500 Vic, Spain. [Ferreira-González I] Grup de Recerca en Malalties Cardiovasculars, Servei de Cardiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red (CIBER) de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Javier Martín-Moreiras, Ignacio J. Amat-Santos, Juan Caballero Borrego, Jesús Jiménez-Mazuecos, Gema Miñana, Julio Núñez, Pablo Salinas, Sergio Rojas, José M. de la Torre Hernández, Guillermo Galeote, Manuel Fuentes, Eva Rumiz, Sandra Santos-Martínez, Fernando Lozano, Soledad Ojeda, José Antonio Fernández-Díaz, Javier Cuesta, Daniela Dubois, Javier Lacunza, Javier Goicolea, Javier Escaned, Alejandro Diego-Nieto, Alfonso Jurado, Sergio Rodríguez-Leiras, Manel Sabaté, Victoria Martin-Yuste, Francisco J Morales-Ponce, Juan Sanchis, Nieves Gonzalo, Miriam Jiménez-Fernández, Raúl Millán, Alejandro Gutiérrez, María M. López, Juan Rondan, Manuel Pan, Francisco Bosa Ojeda, Víctor H Moreno, Beatriz Vaquerizo, Fernando Rivero, J. Robles, Dae-Hyun Lee, Mohsen Mohandes, [Salinas,P, Gonzalo,N, Moreno,VH, Escaned,J] Cardiology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Fuentes,M] Servicio de Medicina Preventiva, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain. [Santos-Martinez,S, Amat-Santos,IJ] Instituto de Ciencias del Corazón (ICICOR), Hospital Clínico Universitario de Valladolid, Valladolid, Spain. [Fernandez-Diaz,JA, Goicolea,J] Interventional Cardiology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain. [Bosa Ojeda,F] Servicio de Cardiología, H. Tenerife, Tenerife, Spain. [Caballero Borrego,J, Jiménez-Fernández,M] Servicio de Cardiología, HU. San Cecilio, Granada, Spain. [Cuesta,J, Rivero,F] Servicio de Cardiología, H. de la Princesa, Madrid, Spain. [de la Torre Hernández,JM, Lee,DH] Servicio de Cardiología, H. Valdecilla, Santander, Spain. [Diego-Nieto,A, Martin-Moreiras,J] Servicio de Cardiología, Complejo Asistencial Universitario de Salamanca, IBSAL, CIBERCV, Salamanca, España. [Dubois,D, Millán,R, Vaquerizo,B] Servicio de Cardiología, H. del Mar, Barcelona, Spain. [Galeote,G, Jurado,A] Servicio de Cardiología, H. la Paz, Madrid, Spain. [Gutiérrez,A] Servicio de Cardiología, H. Jerez, Jerez, Spain. [Jiménez-Mazuecos,J] Servicio de Cardiología, H. Albacete, Albacete, Spain. [Jurado,A, Lozano,F] Servicio de Cardiología, H. Ciudad Real, Ciudad Real, Spain. [Lacunza,J] Servicio de Cardiología, H. de la Arrixaca, Murcia, Spain. [López,M] Servicio de Cardiología, H. León, León, Spain. [Martin-Yuste,V, Sabaté,M] CIBER CV, IDIBAPS, Instituto Cardiovascular, Servicio de Cardiología, H. Clinic Barcelona, Spain. [Miñana,G, Núñez,J, Sanchís,J] Servicio de Cardiología, H. Clínico de Valencia. Universidad de Valencia, CIBERCV, Valencia, Spain. [Mohandes,M, Rojas,S] Servicio de Cardiología, H. Joan XXIII, Tarragona, Spain. [Morales-Ponce,FJ] Servicio de Cardiología, H. Puerto Real, Puerto Real, Spain. [Ojeda,S, and Pan,M] Reina Sofia Hospital, Maimonides Institute for Research in Biomedicine of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain. [Robles,J] Servicio de Cardiología, H. Burgos, Burgos, Spain. [Rodríguez-Leiras,S] Servicio de Cardiología, H. Virgen de la Macarena, Málaga, Spain. [Rondán,J] Servicio de Cardiología, H. Cabueñes, Gijón, Spain. [Rumiz,E] Servicio de Cardiología, H. General de Valencia, Valencia, Spain.

Jordà, Paloma, Toro, Rocío, Diez, Carles, Salazar-Mendiguchía, Joel, Fernandez-Falgueras, Anna, Perez-Serra, Alexandra, Coll, Monica, Puigmulé, Marta, Arbelo, Elena, García-Álvarez, Ana, Sarquella-Brugada, Georgia, Cesar, Sergi, Tiron, Coloma, Iglesias, Anna, Brugada, Josep, Brugada, Ramon, Campuzano, Oscar, [Jordà,P, Arbelo,E, García-Álvarez,A, Brugada,J] Cardiology Department, Hospital Clinic, University of Barcelona-IDIBAPS, Barcelona, Spain. [Toro,R] Medicine Department, School of Medicine, University of Cadiz, Cadiz, Spain. [Toro,R] Biomedical Research and Innovation Institute of Cadiz (INiBICA), Cadiz, Spain. [Diez,C, Salazar-Mendiguchía,J] Cardiovascular Diseases Research Group Bellvitge Biomedical Research Institute (IDIBELL) Hospitalet de Llobregat, Barcelona, Spain. [Diez,C] Advanced Heart Failure and Heart Transplant Unit Department of Cardiology Bellvitge University Hospital Hospitalet de Llobregat, Barcelona, Spain. [Fernandez-Falgueras,A, Perez-Serra,A, Coll,M, Puigmulé,M, Iglesias,A, Brugada,R, Campuzano,O] Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain. [Perez-Serra,A, Brugada,J, Campuzano,O] Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Sarquella-Brugada,G, Cesar,S, Campuzano,O] Pediatric Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Cardiology Department, Hospital Sant Joan de Déu, University of Barcelona, Barcelona, Spain. [Sarquella-Brugada,G, Campuzano,O] Medical Science Department, School of Medicine, University of Girona, Girona, Spain. [Tiron,C, Brugada,R] Cardiology Service, Hospital Josep Trueta, University of Girona, Girona, Spain., and This work was supported by Obra Social 'La Caixa Foundation' (LCF/PR/GN16/50290001 and LCF/PR/GN19/50320002), Fondo Investigacion Sanitaria (FIS PI16/01203 and FIS, PI17/01690) from Instituto Salud Carlos III (ISCIII), and 'Fundacio Privada Daniel Bravo Andreu'. CIBERCV is an initiative of the ISCIII, Spanish Ministry of Economy and Competitiveness.

Calvet-Mirabent, Marta, Sánchez-Cerrillo, Ildefonso, Martín-Cófreces, Noa, Martínez-Fleta, Pedro, de la Fuente, Hortensia, Tsukalov, Ilya, Delgado-Arevalo, Cristina, Calzada García, María Josefa, Santos Gil, Ignacio de los, Sanz Sanz, Jesús, García-Fraile, Lucio, Sánchez Madrid, Francisco, Alfranca González, Arantzazu, Muñoz Fernández, María Angeles, Buzón, Maria J., Martín-Gayo, Enrique, Institut Català de la Salut, [Calvet-Mirabent M, Sánchez-Cerrillo I] Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain. Universidad Autónoma de Madrid, Madrid, Spain. [Martín-Cófreces N] Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain. Universidad Autónoma de Madrid, Madrid, Spain. Centro de Investigación Biomédica en Red Cardiovascular, CIBERCV, Madrid, Spain. [Martínez-Fleta P] Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain. [de la Fuente H] Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain. Centro de Investigación Biomédica en Red Cardiovascular, CIBERCV, Madrid, Spain. [Tsukalov I] Universidad Autónoma de Madrid, Madrid, Spain. [Buzón MJ] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Ministerio de Ciencia y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Comunidad de Madrid (España), Gilead Sciences (Spain), Fundación La Caixa, Instituto de Salud Carlos III, and Ministerio de Ciencia e Innovación (España)

[Penela P, Mayor Jr F] Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (UAM-CSIC), Madrid, Spain. Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Inserte J, Rodriguez-Sinovas A, Garcia-Dorado D] CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Ramos P] Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (UAM-CSIC), Madrid, Spain and Hospital Universitari Vall d'Hebron

[Valls-Lacalle L, Negre-Pujol C, Valera-Cañellas A, Consegal M, Rodríguez-Sinovas A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Rodríguez C] Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Institut de Recerca del Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona, Spain. [Varona S] Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC), Barcelona, Spain. Institut de Recerca del Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona, Spain and Hospital Universitari Vall d'Hebron

Sandra Rayego-Mateos, Mercedes Vallejo-Mudarra, Isabel Cortegano, María Luisa Gaspar, Carmen Herencia-Bellido, Lucas Opazo-Ríos, Melania Guerrero-Hue, Cristina Vázquez-Carballo, José Luis Morgado-Pascual, Cristina García-Caballero, Juan Antonio Moreno, Belén de Andrés, Jesús Egido, [Vázquez-Carballo,C, Rayego-Mateos,S, Opazo-Ríos,L, Herencia-Bellido,C, Egido,J] Renal, Vascular and Diabetes Research Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain. [Guerrero-Hue,M, García-Caballero,C, Morgado-Pascual,JL, Vallejo-Mudarra,M, Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Hospital Universitario Reina Sofía, Córdoba, Spain. [Opazo-Ríos,L, Egido,J] Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. [Cortegano,I, Gaspar,ML, de Andrés,B] Immunobiology Department, Carlos III Health Institute, Majadahonda (Madrid), Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Moreno,JA] Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, The authors work has been supported by grants from Instituto de Salud Carlos III (ISCIII, FIS-FEDER PI17/00130, PI17/01495, PI20/00375, PI20/00487), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Spanish Ministry of Science and Innovation (RTI2018-099114-B-100, RTI2018-098788-B-100, DTS19/00093, RYC-2017-22369), and Spanish Societies of Cardiology (SEC), Nephrology (SEN) and Atherosclerosis (SEA). The 'PFIS' and 'Sara Borrell' training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021) and CH-B (CP16/00017). Córdoba University supported the salary of C.G.C. No other relevant affiliations or financial involvement exist with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties., Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Sociedad Española de Cardiología, Sociedad Española de Nefrología, Sociedad Española de Arteriosclerosis, University of Córdoba (España), UAM. Departamento de Farmacología, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), and Universidad de Córdoba

Bermejo, Javier, González-Mansilla, Ana, Mombiela, Teresa, Fernández, Ana I., Martínez-Legazpi, Pablo, Yotti, Raquel, García-Orta, Rocío, Sánchez-Fernández, Pedro L., Castaño, Mario, Segovia-Cubero, Javier, Escribano-Subias, Pilar, San Román, J.Alberto, Borràs Pino, Xavier, Alonso-Gómez, Ángel María, Botas, Javier, Crespo-Leiro, Maria Generosa, Velasco, Sonia, Bayés-Genís, Antoni, López, Amador, Muñoz-Aguilera, Roberto, Jiménez-Navarro, Manuel, González-Juanatey, José R., Evangelista, Arturo, Elízaga, Jaime, Martín-Moreiras, Javier, González-Santos, José M., Moreno-Escobar, Eduardo, Fernández Avilés, F., García-Robles, José A., Pérez-David, Esther, Pérez Del Villar, Candelas, Sanz, Ricardo, Gutierrez-Ibanes, Enrique, Vázquez, María E., Mur, Ana, Benito, Yolanda, Barrio, Alicia, Vázquez, Alexandra, Uribe, Inés, González, Mercedes, Arribas, Antonio, Clemente Lorenzo, M. Milagros, Nieto, Alejandro Diego, Pérez De Prado, Armando, Alonso, David, Gómez-Bueno, Manuel, Sayago Silva, Inés, Cavero, Miguel Ángel, Domínguez, Laura, Tello De Meneses, Rocío, Ruíz Cano, María José, Jiménez López-Guarch, Carmen, Mota, Pedro, Amorós Galitó, Carmen, Belló Mora, M. Concepción, Mesa Rubio, Dolores, Campuzano, Raquel, Marzoa, Raquel, Cuenca, José, Muñoz, Roberto, Suberviola, Verónica, Beltrán Herrera, Cristina, Mora, Laura, Sarrión, M. Mar, Vaqueriza, David, Ferrer, Elena, Cid-Álvarez, Belén, Martínez Monzonís, Amparo, Arizón De Prado, José M., Santisteban, Marta, García-Dorado, David, De Teresa, Eduardo, Carrasco-Chinchilla, Fernando, Alonso, Joaquín, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), European Regional Development Fund (ERDF/FEDER), Centro de Investigación Biomedica en Red - CIBER, Institut Català de la Salut, [Bermejo J, González-Mansilla A, Mombiela T, Fernández AI, Martínez-Legazpi P] Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, and CIBERCV Madrid Spain. [Yotti R] Instituto de Salud Carlos III Madrid Spain. [Evangelista A] Vall d'Hebron Hospital Universitari, Barcelona, Spain. CIBERCV Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Ivan Milinković, Antoni Bayes-Genis, Henrike Arfsten, Tiny Jaarsma, Patrick Rossignol, Arantxa González, Pardeep S. Jhund, James L. Januzzi, Rudolf A. de Boer, A. Mark Richards, Andrew J.S. Coats, Michele Emdin, Giuseppe M.C. Rosano, Christian Mueller, Petar M. Seferovic, Julio Núñez, BOZEC, Erwan, Heart Institute, Hospital Universitari Germans Trias i Pujol, CIBERCV, Instituto de Salud Carlos III, Massachusetts General Hospital [Boston], Baim Institute for Clinical Research Boston MA, Harvard Medical School [Boston] (HMS), Cardiovascular Research Institute, National University Heart Centre, University of Otago [Dunedin, Nouvelle-Zélande], Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, University Medical Center Groningen [Groningen] (UMCG), Fondazione Toscana Gabriele Monasterio, Institute of Life Sciences, Scuola Superiore Sant'Anna, Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA, Pamplona, Spain, CIBERCV, Carlos III Institute of Health, Division of Nursing Sciences and Reproductive Health, Department of Health, Medicine and Caring Sciences, Linköping University, British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC), University of Glasgow-NHS Greater Glasgow and Clyde, University Hospital Basel [Basel], University of Basel (Unibas), Biomedical Research Institute [Valencia, Spain] (INCLIVA ), Universitat de València (UV), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University of Belgrade [Belgrade], niversity and IRCCS San Raffaele, University of Warwick [Coventry], Monash University [Melbourne], Serbian Academy of Sciences and Arts (SASA), and Cardiovascular Centre (CVC)

Simon Colreavy-Donnelly, Saul Calderon-Ramirez, Shengxiang Yang, Ezequiel López-Rubio, David Elizondo, Manuel F. Jiménez-Navarro, Armaghan Moemeni, Luis Oala, Jorge Rodriguez-Capitan, Miguel A. Molina-Cabello, [Calderon-Ramirez, Saul] De Montfort Univ, Sch Comp Sci & Informat, Leicester LE1 9BH, Leics, England, [Yang, Shengxiang] De Montfort Univ, Sch Comp Sci & Informat, Leicester LE1 9BH, Leics, England, [Colreavy-Donnelly, Simon] De Montfort Univ, Sch Comp Sci & Informat, Leicester LE1 9BH, Leics, England, [Elizondo, David A.] De Montfort Univ, Sch Comp Sci & Informat, Leicester LE1 9BH, Leics, England, [Calderon-Ramirez, Saul] Inst Tecnol Costa Rica, Cartago 30101, Costa Rica, [Moemeni, Armaghan] Univ Nottingham, Sch Comp Sci, Nottingham NG8 1BB, England, [Oala, Luis] Fraunhofer Heinrich Hertz Inst, XAI Grp, Artificial Intelligence Dept, D-10587 Berlin, Germany, [Rodriguez-Capitan, Jorge] Hosp Univ Virgen Victoria, CIBERCV, Malaga 29010, Spain, [Jimenez-Navarro, Manuel] Hosp Univ Virgen Victoria, CIBERCV, Malaga 29010, Spain, [Lopez-Rubio, Ezequiel] Univ Malaga, Dept Comp Languages & Comp Sci, Malaga 29071, Spain, [Molina-Cabello, Miguel A.] Univ Malaga, Dept Comp Languages & Comp Sci, Malaga 29071, Spain, [Lopez-Rubio, Ezequiel] Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain, [Molina-Cabello, Miguel A.] Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain, Universidad de Malaga, Instituto de Investigacion Biomedica de Malaga (IBIMA), and Publica

Francesc E. Borràs, S. Roura, Adriana Cserkóová, Paloma Gastelurrutia, Miriam Morón-Font, Anna Rosell, Carolina Gálvez-Montón, Alexandra Calle, Marta Monguió-Tortajada, Anna Morancho, Antoni Bayes-Genis, Marta Clos-Sansalvador, Miguel Ángel Ramírez, Cristina Prat-Vidal, Institut Català de la Salut, [Monguió-Tortajada M] ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Spain. REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERCV, Instituto de Salud Carlos III, Madrid, Spain. [Prat-Vidal C, Gastelurrutia P] ICREC Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Spain. CIBERCV, Instituto de Salud Carlos III, Madrid, Spain. Institut d’Investigació Biomèdica de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Spain. [Moron-Font M] REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Spain. [Clos-Sansalvador M] REMAR-IVECAT Group, Health Science Research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Calle A] Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid, Spain. [Morancho A, Rosell A] Laboratori d'Investigació Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Sergio Rius-Pérez, Carmen Choya-Foces, Jordi Muntané, María A. Rodríguez-Hernández, Antonio Miranda-Vizuete, C. Alicia Padilla, Raúl González, Antonio Martínez-Ruiz, Juan Sastre, María Negrete, Patricia de la Cruz-Ojeda, Kalina Ranguelova, Anne-Odile Hueber, José Antonio Bárcena, Aurélie Rossin, [González,R, Rodríguez-Hernández,MA, Negrete,M, de la Cruz-Ojeda,P, Miranda-Vizuete,A, Muntané,J] Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen Del Rocío'/CSIC/University of Seville, Seville, Spain. [Ranguelova,K] Bruker BioSpin Corporation, Billerica, MA, USA. [Rossin,A, Hueber,AO] Université Côte D'Azur, CNRS, Inserm, iBV, Nice, France. [Choya-Foces,C, Martínez-Ruiz,A] Research Unit, Hospital University 'Santa Cristina', Health Research Institute 'La Princesa' (IIS-IP), Madrid, Spain. [Choya-Foces,C, Martínez-Ruiz,A] Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Rius-Pérez,S, Sastre,J] Department of Physiology, Faculty of Pharmacy, University of Valencia. Burjassot, Valencia, Spain. [Bárcena,JA, Padilla,CA] Department of Biochemistry and Molecular Biology, University of Cordoba, Cordoba, Spain. [Bárcena,JA, Padilla,CA] Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain. [Muntané,J] Department of General Surgery, Hospital University 'Virgen del Rocío'/IBiS/CSIC/University of Seville, Seville, Spain. [González,R, Muntané,J] Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd), Madrid, Spain., This study was funded by Institute of Health Carlos III (ISCIII) (PI13/00021, PI15/00107, PI16/00090 and PI19/01266), Spanish Ministry of Economy and Competitiveness (SAF2015-71208-R, BFU2016-8006-P, PGC2018-094276-B-I00 and RED2018-102576-T), Andalusian Ministry of Economy, Innovation, Science and Employment (BIO-216 and CTS-6264) and Andalusian Ministry of Equality, Health and Social Policies (PI-00025-2013 and PI-0198-2016). P de la C–O was supported by FPU predoctoral fellowship (FPU17/00026) from Ministry of Education, Culture and Sports. We thank the Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), and the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCIII and co-financed by European Development Regional Fund 'A way to achieve Europe' ERDF for their financial support., Institute of Biomedicine of Seville (IBIS), Bruker Biospin Corporation, Billerica, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Santa Cristina University Hospital, University of Valencia, Valencia, University of Córdoba [Córdoba], Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Servicio de Immunologia, Hospital Universitario de la Princesa-Instituto de Investigacion Sanitaria Princesa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), and European Commission

de la Fuente-Alonso, Andrea, Toral, Marta, Alfayate, Alvaro, Ruiz-Rodríguez, María Jesús, Bonzon-Kulichenko, Elena, Teixido-Tura, Gisela, Martínez-Martínez, Sara, Méndez-Olivares, María José, López-Maderuelo, Dolores, González-Valdés, Ileana, Garcia-Izquierdo, Eusebio, Mingo, Susana, Martín, Carlos E., Muiño-Mosquera, Laura, De Backer, Julie, Nistal, J. Francisco, Forteza, Alberto, Evangelista Masip, Arturo, Vázquez, Jesús, Campanero, Miguel R., Redondo, Juan Miguel, Universidad Autònoma de Barcelona, La Caixa, Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Institut Català de la Salut, [de la Fuente-Alonso A, Toral M, Ruiz-Rodríguez MJ] Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Alfayate A] Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Cardiovascular Proteomics Laboratoy, CNIC, Madrid, Spain. [Bonzón-Kulichenko E] Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Cardiovascular Proteomics Laboratoy, CNIC, Madrid, Spain. [Teixido-Tura G, Evangelista A] Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Santiago Aguadé-Bruix, Guillermo Romero-Farina, Institut Català de la Salut, [Romero-Farina G] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERCV, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Aguadé-Bruix S] Servei de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERCV, Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Sandra Rayego-Mateos, José Luis Morgado-Pascual, Javier Egea, Sebastian Mas, José M. Villalba, Alfonso Rubio-Navarro, Lucas Opazo-Ríos, Alejandra Palomino-Antolín, Jesús Egido, Cristina García-Caballero, Melania Guerrero-Hue, Alberto Ortiz, Juan Antonio Moreno, Carmen Herencia, Cristina Vázquez-Carballo, UAM. Departamento de Medicina, [Guerrero-Hue,M, Rayego-Mateos,S, García-Caballero,C, Morgado-Pascual,JL, Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. [Vázquez-Carballo,C, Opazo-Rios,L, Herencia,C, Mas,S, Ortiz,A, Egido,J] Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, Madrid, Spain. [Palomino-Antolín,A, Egea,J] Research Unit, Hospital Universitario Santa Cristina, IIS-Hospital Universitario de la Princesa, Madrid, Spain. [Palomino-Antolín,A, Egea,J] Departament of Pharmacology and Therapeutics, Medicine Faculty, Instituto Teófilo Hernando, Autónoma University, Madrid, Spain. [Opazo-Rios,L, Egido,J] Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. [Ortiz,A] Red Nacional Investigaciones Nefrológicas (REDINREN), Madrid, Spain. [Rubio-Navarro,A] Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. [Villalba,JM, Moreno,JA] Department of Cell Biology, Physiology, and Immunology, Agrifood Campus of International Excellence (ceiA3), University of Cordoba, Cordoba, Spain. [Moreno,JA] Hospital Universitario Reina Sofia, Cordoba, Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain., and The authors’ work has been supported by grants FIS/Fondos FEDER (PI17/00130, PI17/00257, PI17/01495, PI18/01386, PI19/00815, PI20/00375, PI20/00487 ISCIII-RETIC REDinREN RD016/0009), Sociedad Española de Nefrología, FRIAT, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM) and Cardiovascular (CIBERCV), Spanish Ministry of Science and Innovation (RTI2018-098788-B-100, DTS17/00203, DTS19/00093, RYC-2017-22369, FJC2019-042028), The 'PFIS'and 'Sara Borrell' training program of the ISCIII supported the salary of MGH (FI18/00310), SR-M (CD19/00021), and CH-B (CP16/00017). Spanish Ministerio de Ciencia, Innovación y Universidades (MICIU) grant RTI2018-100695-B-I00, Junta de Andalucía grants P18-RT-4264, 1263735-R and BIO-276, the FEDER Funding Program from the European Union, and Universidad de Córdoba (to J.M.V.). No other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Valls de Lacalle, Laura, Rodríguez, Cristina, Negre-Pujol, Corall, Varona, Saray, Antoni Valera Cañellas, Consegal, Marta, Martínez-González, Jose, Rodríguez-Sinovas, Antonio, Universitat Autònoma de Barcelona, [Valls-Lacalle L, Negre-Pujol C, Valera-Cañellas A, Consegal M, Rodríguez-Sinovas A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Rodríguez C] Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Institut de Recerca del Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona, Spain. [Varona S] Centro de Investigación Biomédica en Red sobre Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC), Barcelona, Spain. Institut de Recerca del Hospital de la Santa Creu i Sant Pau (IIB-Sant Pau), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Fundació La Marató de TV3, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Generalitat de Catalunya, Rodríguez, Cristina [0000-0002-6472-5647], Rodríguez-Sinovas, Antonio [0000-0003-2930-8773], Rodríguez, Cristina, and Rodríguez-Sinovas, Antonio

David Garcia-Dorado, Federico Mayor, Javier Inserte, Antonio Rodríguez-Sinovas, Petronila Penela, Paula Ramos, Instituto de Salud Carlos III, Ministerio de Economía, Industria y Competitividad (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), European Commission, Comunidad de Madrid, Fundación Ramón Areces, UAM. Departamento de Biología Molecular, [Penela P, Mayor Jr F] Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (UAM-CSIC), Madrid, Spain. Instituto de Investigación Sanitaria La Princesa, Madrid, Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Inserte J, Rodriguez-Sinovas A, Garcia-Dorado D] CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Grup de Recerca en Malalties Cardiovasculars, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. [Ramos P] Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (UAM-CSIC), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

José M. Melero, Concepción Santiago-Fernández, Luis Morcillo-Hidalgo, Lourdes Garrido-Sánchez, Amalio Ruiz-Salas, Mercedes Millán-Gómez, Fernando Carrasco-Chinchilla, Manuel F. Jiménez-Navarro, Inmaculada Moreno-Santos, Luis M. Pérez-Belmonte, [Santiago-Fernández,C, Garrido-Sánchez,L] Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, Malaga, Spain. [Santiago-Fernández,C, Garrido-Sánchez,L] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Malaga, Spain. [Pérez-Belmonte,LM, Millán-Gómez,M, Moreno-Santos,I, Carrasco-Chinchilla,F, Ruiz-Salas,A, Morcillo-Hidalgo,L, Melero,JM, Jiménez-Navarro,M] Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Malaga, Spain. [Pérez-Belmonte,LM, Jiménez-Navarro,M] Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Malaga, Spain., and This work was supported by Grants from the Spanish Ministry of Health (FIS) (PI13/02542, PI11/01661) and Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV) (CB16/11/00360), Instituto de Salud Carlos III co-funded by the Fondo Europeo de Desarrollo Regional (FEDER).

Juan P. Rodriguez-Escudero, Abhiram Prasad, Daniel J. Crusan, Ray W. Squires, Luis M. Pérez-Belmonte, Kashish Goel, Randal J. Thomas, Carlos M Diaz-Melean, Francisco Lopez-Jimenez, Ryan J. Lennon, Manuel F. Jiménez-Navarro, [Jimenez-Navarro, Manuel F.] Univ Malaga, Inst Biomed Malaga, Hosp Univ Virgen de la Victoria, UGC Corazon,CIBERCV Enfermedades Cardiovasc, Malaga, Spain, [Perez-Belmonte, Luis M.] Univ Malaga, Inst Biomed Malaga, Hosp Univ Virgen de la Victoria, UGC Corazon,CIBERCV Enfermedades Cardiovasc, Malaga, Spain, [Lopez-Jimenez, Francisco] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Lennon, Ryan J.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Diaz-Melean, Carlos] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Rodriguez-Escudero, J. P.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Goel, Kashish] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Crusan, Daniel] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Prasad, Abhiram] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Squires, Ray W.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Thomas, Randal J.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA, [Lopez-Jimenez, Francisco] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Lennon, Ryan J.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Diaz-Melean, Carlos] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Rodriguez-Escudero, J. P.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Goel, Kashish] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Crusan, Daniel] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Prasad, Abhiram] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Squires, Ray W.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, [Thomas, Randal J.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA, Mayo Clinic Division of Cardiovascular Disease, Instituto de Salud Carlos III (ISCIII) (Ministry of Economy and Competitiveness) (Spain) (Beca BAE), Spanish Ministry of Health, Spanish Cardiovascular Research Network, Fondo Europeo de Desarrollo Regional, Sociedad Andaluza de Cardiologia (Beca Estancia Extranjero), and Red de Investigacion Cardiovascular

Ana Campos, José Ruiz-Cantador, Raquel Prieto, Ana Elvira González-García, Pablo Ávila, Francisco Fernández-Avilés, Pastora Gallego, Raquel Yotti, Esther Cambronero, José M. Oliver, Fernando Sarnago, María José Rodríguez-Puras, Rafael Peinado, [Avila, Pablo] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Maria Oliver, Jose] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Peinado, Rafael] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Sarnago, Fernando] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Yotti, Raquel] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Fernandez-Aviles, Francisco] Univ Complutense Madrid, Fac Med, IiSGM, Dept Cardiol,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Avila, Pablo] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Maria Oliver, Jose] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Peinado, Rafael] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Sarnago, Fernando] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Yotti, Raquel] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Fernandez-Aviles, Francisco] Univ Complutense Madrid, Fac Med, IiSGM, CIBERCV,Hosp Gen Univ Gregorio Maranon, Madrid, Spain, [Maria Oliver, Jose] Hosp Univ La Paz, Adult Congenital Heart Dis Unit, Madrid, Spain, [Gonzalez-Garcia, Ana] Hosp Univ La Paz, Adult Congenital Heart Dis Unit, Madrid, Spain, [Cambronero, Esther] Hosp Univ La Paz, Adult Congenital Heart Dis Unit, Madrid, Spain, [Ruiz-Cantador, Jose] Hosp Univ La Paz, Adult Congenital Heart Dis Unit, Madrid, Spain, [Prieto, Raquel] Hosp Univ La Paz, Adult Congenital Heart Dis Unit, Madrid, Spain, [Gallego, Pastora] Hosp Virgen Rocio & Virgen Macarena, Interctr Congenital Heart Dis Unit, Seville, Spain, [Jose Rodriguez-Puras, Maria] Hosp Virgen Rocio & Virgen Macarena, Interctr Congenital Heart Dis Unit, Seville, Spain, [Campos, Ana] Hosp Virgen Rocio & Virgen Macarena, Interctr Congenital Heart Dis Unit, Seville, Spain, Instituto de Salud Carlos III, Ministerio de Economia y Competividad, Spain, and Instituto de Salud Carlos III - European Regional Development Funds (ERDF)

José R. González-Juanatey, Jose Luis Górriz, Alberto Ortiz, Alfonso Valle, Maria Jose Soler, Lorenzo Facila, Institut Català de la Salut, [González-Juanatey JR] Cardiology Department, Hospital Clínico Universitario Santiago de Compostela, Centro de investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Santiago de Compostela, Spain. [Górriz JL] Nephrology Department, Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain. [Ortiz A] Nephrology Department, Fundación Jiménez Díaz, Madrid, Spain. [Valle A] Cardiology Department, Hospital La Salud, Valencia, Spain. [Soler MJ] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Facila L] Cardiology Department, Consorcio Hospital General Universitario de Valencia, Valencia, Spain, and Vall d'Hebron Barcelona Hospital Campus

Abumayyaleh, Mohammad, Nuñez Gil, Ivan Javier, Viana-Llamas, María C., RAPOSEIRAS-ROUBIN, SERGIO, Romero, Rodolfo, Alfonso, Emilio, Uribarri, Aitor, Institut Català de la Salut, [Abumayyaleh M] Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, Mannheim, Germany. [Núñez Gil IJ] Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación, Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Viana-LLamas MC] Hospital Universitario Guadalajara, Guadalajara, Spain. [Raposeiras Roubin S] University Hospital Álvaro Cunqueiro, Vigo, Spain. [Romero R] Hospital Universitario Getafe, Getafe, Universidad Europea, Madrid, Spain. [Alfonso-Rodríguez E] Hospital University of Bellvitge, Barcelona, Spain. [Uribarri A] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigacion Biomedica en Red para Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Almudena Val-Blasco, Patricia Prieto, Rafael Iñigo Jaén, Marta Gil-Fernández, Marta Pajares, Nieves Domenech, Verónica Terrón, María Tamayo, Inmaculada Jorge, Jesús Vázquez, Andrea Bueno-Sen, María Teresa Vallejo-Cremades, Jorge Pombo-Otero, Sergio Sanchez-García, Gema Ruiz-Hurtado, Ana María Gómez, Carlos Zaragoza, María Generosa Crespo-Leiro, Eduardo López-Collazo, Antonio Cuadrado, Carmen Delgado, Lisardo Boscá, María Fernández-Velasco, Ministerio de Economía y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Instituto de Salud Carlos III, Sociedad Española de Cardiología, Unión Europea. Fondo Social Europeo (ESF/FSE), Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares), Ministerio de Ciencia, Innovación y Universidades (España), Fundación La Caixa, Agencia Estatal de Investigación (España), and Fundación 'la Caixa'

Domènec Serrano, Ruth Martí-Lluch, Mérida Cárdenas, Pascual Solanas, Jaume Marrugat, Joan Vilalta-Franch, Josep Garre-Olmo, [Serrano D] Institut de Recerca Biomèdica de Girona (IDIBGI), Salt, Spain. Institut d'Assistència Sanitària, Salt, Spain. Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. [Martí-Lluch R] Institut de Recerca Biomèdica de Girona (IDIBGI), Salt, Spain. Grup de Recerca en Salut Vascular (ISV-Girona), Fundació Institut Universitari d'Investigació en Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain. [Cárdenas M] Servei de Cardiologia, Hospital Dr. Josep Trueta, Girona, Spain. [Solanas P] Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. Grup de Recerca en Salut Vascular (ISV-Girona), Fundació Institut Universitari d'Investigació en Atenció Primària de Salut Jordi Gol i Gurina, Barcelona, Spain. [Marrugat J] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. CIBERCV de recerca en Malalties Cardiovasculars, Madrid, Spain. [Vilalta-Franch J] Institut de Recerca Biomèdica de Girona (IDIBGI), Salt, Spain. [Garre-Olmo J] Institut de Recerca Biomèdica de Girona (IDIBGI), Salt, Spain. Institut d'Assistència Sanitària, Salt, Spain, and Institut d'Assistència Sanitària

Isabel Mayoral-González, Eva M. Calderón-Sánchez, Isabel Galeano-Otero, Marta Martín-Bórnez, Encarnación Gutiérrez-Carretero, María Fernández-Velasco, Nieves Domenech, María Generosa Crespo-Leiro, Ana María Gómez, Antonio Ordóñez-Fernández, Abdelkrim Hmadcha, Tarik Smani, Universidad de Sevilla / University of Sevilla, Biomedicine Institute of Sevilla [Seville, Spain], Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares [Spain] (CIBERCV), La Paz University Hospital, Universidade da Coruña, Signalisation et physiopathologie cardiovasculaire (CARPAT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Alicante [Spain], Universidad Pablo de Olavide [Sevilla] (UPO), Gomez, Ana Maria, European Commission, Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Junta de Andalucía, and Agence Nationale de la Recherche (France)

Sergio Garcia-Segura, Javier del Rey, Laia Closa, Iris Garcia-Martínez, Carlos Hobeich, Ana Belén Castel, Francisco Vidal, Jordi Benet, Maria Oliver-Bonet, Institut Català de la Salut, [Garcia-Segura S, Del Rey J] Unit of Cell Biology and Medical Genetics, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Closa L] Histocompatibility and Immunogenetics Laboratory, Banc de Sang i Teixits (BST), Barcelona, Spain. Medicina Transfusional, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. [Garcia-Martínez I, Hobeich C] Grup de Recerca de Medicina Transfusional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Coagulopaties Congènites, Banc de Sang i Teixits (BST), Barcelona, Spain. [Castel AB] Instituto de Fertilidad, Palma de Mallorca, Spain. [Vidal F] Grup de Recerca de Medicina Transfusional, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Coagulopaties Congènites, Banc de Sang i Teixits (BST), Barcelona, Spain. CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus

Girerd, Nicolas, Leclercq, Christophe, Hanon, Olivier, Bayés-Genís, Antoni, Januzzi, James, Damy, Thibaut, Lequeux, Benoit, Meune, Christophe, Sabouret, Pierre, Roubille, François, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Hôpitaux Universitaires Paris Centre, Université Paris Cité (UPCité), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain] (GTPUH), Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Baim Institute for Clinical Research Boston MA, CHU Henri Mondor [Créteil], Service de cardiologie [CHU de Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)