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2,439 results on '"CHU Saint-Etienne"'

1. EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors (EPIK)

Author

Institut Paoli-Calmettes, CHRU Lille, hematology department, CH Annecy Genevois, Institut Bergonié Bordeaux, hematology department, CHU Nancy, hematology department, CHU Saint-Etienne, hematology department, Institut Universitaire du Cancer de Toulouse - Oncopole, hematology department, CHU Caen, hematology department, CHU Nice, hematology department, CHU Lyon, hematology department, AP-HP, hematology department, AP-HP Hôpital Henri-Mondor, hematology department, Versailles Hospital, Centre Leon Berard, and University Hospital, Grenoble

Published
2024

5. Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Author

Writing Group (denotes joint first author) James, C Glasbey (UK), Dmitri Nepogodiev (UK), Joana FF Simoes (Portugal), Omar Omar (UK), Elizabeth Li (UK), Mary, L Venn (UK), Mohammad Abou Chaar (Jordan), Vita Capizzi (Italy), Daoud Chaudhry (UK), Anant Desai (UK), Jonathan, G Edwards (UK), Jonathan, P Evans (UK), Marco Fiore (Italy), Jose Flavio Videria (Portugal), Samuel, J Ford (UK), Ian Ganyli (USA), Ewen, A Griffiths (UK), Rohan, R Gujjuri (UK), Angelos, G Kolias (UK), Haytham MA Kaafarani (USA), Ana Minaya-Bravo (Spain), Siobhan, C McKay (UK), Helen, M Mohan (Ireland), Keith Roberts (UK), Carlos San Miguel-M&#233, ndez (Spain), Peter Pockney (Australia), Richard Shaw (UK), Neil, J Smart (UK), Grant, D Stewart (UK), Sudha Sundar (UK), Raghavan Vidya (UK), Aneel, A Bhangu (UK, Statistical analysis Glasbey JC, Overall guarantor)., Omar, O (Lead statistician), Bhangu, A CovidSurg Operations Committee Kwabena Siaw-Acheampong, Ruth, A Benson, Edward, Bywater, Daoud, Chaudhry, Brett, E Dawson, Jonathan, P Evans, James, C Glasbey, Rohan, R Gujjuri, Emily, Heritage, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, Rachel, A Khaw, James, M Keatley, Andrew, Knight, Samuel, Lawday, Elizabeth, Li, Harvinder, S Mann, Ella, J Marson, Kenneth, A McLean, Siobhan, C Mckay, Emily, C Mills, Dmitri, Nepogodiev, Gianluca, Pellino, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Joana FF Simoes, Isobel, M Trout, Mary, L Venn, Richard JW Wilkin, International Cancer Leads (denotes specialty Principal Investigators) James C Glasbey (Chair), Aneel Bhangu., Colorectal: Neil, J Smart, Ana, Minaya-Bravo, Susan, Moug, Dale, Vimalchandran, Abigail, Vallance, Peter, Pockney, Oesophagogastric: Ewen, A Griffiths, Richard PT Evans, Philip, Townend, Hepatopancreatobilary: Keith Roberts, Siobhan, McKay, John, Isaac, Sohei, Satoi, Thoracic: John Edwards, Aman, S Coonar, Adrian, Marchbank, Edward, J Caruana, Georgia, R Layton, Akshay, Patel, Alessandro, Brunelli, Sarcoma: Samuel Ford, Anant, Desai, Alessandro, Gronchi, Marco, Fiore, Max, Almond, Fabio, Tirotta, Sinziana, Dumitra, Neurosurgery: Angelos Kolias, Stephen, J Price, Daniel, M Fountain, Michael, D Jenkinson, Peter, Hutchinson, Hani, J Marcus, Rory, J Piper, Laura, Lippa, Franco, Servadei, Ignatius, Esene, Christian, Freyschlag, Iuri, Neville, Gail, Rosseau, Karl, Schaller, Andreas, K Demetriades, Faith, Robertson, Alex, Alamri, Head and neck: Richard Shaw, Andrew, G Schache, Stuart, C Winter, Michael, Ho, Paul, Nankivell, Juan Rey Biel, Martin, Batstone, Ian, Ganly, Breast: Raghavan Vidya, Alex, Wilkins, Jagdeep, K Singh, Dinesh, Thekinkattil, Gynaecology: Sudha Sundar, Christina, Fotopoulou, Elaine, Leung, Tabassum, Khan, Luis, Chiva, Jalid, Sehouli, Anna, Fagotti, Paul, Cohen, Murat, Gutelkin, Rahel, Ghebre, Thomas, Konney, Rene, Pareja, Rob, Bristow, Sean, Dowdy, Shylasree TS Rajkumar, Joe, Ng, Keiiji, Fujiwara, Urology: Grant, D Stewart, Benjamin, Lamb, Krishna, Narahari, Alan, McNeill, Alexandra, Colquhoun, John, McGrath, Steve, Bromage, Ravi, Barod, Veeru, Kasivisvanathan, Dissemination Committee Joana FF Simoes (Chair), Tobias Klatte., Tom EF Abbott, Michel, Adamina, Adesoji, O Ademuyiwa, Arnav, Agarwal, Ehab, Alameer, Derek, Alderson, Felix, Alakaloko, Markus, Albertsmeiers, Osaid, Alser, Muhammad, Alshaar, Sattar, Alshryda, Alexis, P Arnaud, Knut Magne Augestad, Faris, Ayasra, Jos&#233, Azevedo, Brittany, K Bankhead-Kendall, Emma, Barlow, Ruth, Blanco-Colino, Amanpreet, Brar, Kerry, A Breen, Chris, Bretherton, Igor Lima Buarque, Joshua, Burke, Mohammad, Chaar, Sohini, Chakrabortee, Peter, Christensen, Daniel, Cox, Moises, Cukier, Miguel, F Cunha, Giana, H Davidson, Salomone Di Saverio, Thomas, M Drake, John, G Edwards, Muhammed, Elhadi, Sameh, Emile, Shebani, Farik, J Edward Fitzgerald, Samuel, Ford, Tatiana, Garmanova, Gaetano, Gallo, Dhruv, Ghosh, Gustavo Mendon&#231, a Ata&#237, de Gomes, Gustavo, Grecinos, Ewen, A Griffiths, Madalegna, Gr&#252, ndl, Constantine, Halkias, Ewen, M Harrison, Intisar, Hisham, Peter, J Hutchinson, Shelley, Hwang, Arda, Isik, Pascal, Jonker, Haytham MA Kaafarani, Angelos, Kolias, Schelto, Kruijff, Ismail, Lawani, Hans, Lederhuber, Sezai, Leventoglu, Andrey, Litvin, Andrew, Loehrer, Markus, W L&#246, ffler, Maria Aguilera Lorena, Maria Marta Madolo, Piotr, Major, Janet, Martin, Hassan, N Mashbari, Dennis, Mazingi, Symeon, Metallidis, Helen, M Mohan, Rachel, Moore, David, Moszkowicz, Joshua, S Ng-Kamstra, Mayaba, Maimbo, Milagros, Niquen, Faustin, Ntirenganya, Maricarmen, Olivos, Kacimi, Oussama, Oumaima, Outani, Marie Dione Parreno-Sacdalanm, Francesco, Pata, Carlos Jose Perez Rivera, Thomas, D Pinkney, Willemijn van der Plas, Ahmad, Qureshi, Dejan, Radenkovic, Antonio Ramos- De la Medina, Keith, Roberts, April, C Roslani, Martin, Ruteg&#229, Ir&#232, ne, Santos, Raza, Sayyed, Andrew, Schache, Andreas, A Schnitzbauer, Seyi-Olajide, Justina O., Neil, Sharma, Richard, Shaw, Sebastian, Shu, Kjetil, Soreide, Antonino, Spinelli, Grant, D Stewart, Malin, Sund, Sudha, Sundar, Stephen, Tabiri, Georgios, Tsoulfas, Gabrielle, H van Ramshorst, Raghavan, Vidya, Dale, Vimalachandran, Oliver, J Warren, Duane, Wedderburn, Naomi, Wright, EuroSurg, European Society of Coloproctology (ESCP), Global Initiative for Children&#8217, s Surgery (GICS), GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Society of Colorectal Surgery (SICCR), Association of Surgeons in Training (ASiT), Irish Surgical Research Collaborative (ISRC), Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), Collaborators (denotes Site Principal Investigators) Argentina: Allemand C, Italian Society of Surgical Oncology (SICO)., Boccalatte, L, Figari, M, Lamm, M, Larra&#241, aga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L (Hospital Italiano De Buenos Aires), Alurralde, C, Caram, El, Eskinazi, D, Mendoza, Jp, Usandivaras M (Sanatorio, 9 De Julio Sa), Badra, R, Esteban, A, Garc&#237, a, Js, a, Pm, Gerchunoff, Ji, Lucchini, Sm, NIgra, Ma, Armenia: Hovhannisyan T, Vargas L (Sanatorio Allende)., Australia: Gould T, Stepanyan A (Nairi Medical Center)., Gourlay, R, Griffiths, B (Calvary Mater Newcastle), Gananadha S, McLaren M (Canberra Hospital), Cecire, J, Joshi, N, Salindera, S, Sutherland, A (Coffs Harbour Health Campus), Ahn, Jh, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H (Concord Repatriation General Hospital), Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo UG (Fiona Stanley Hospital), Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, Yh, Ong, Bs, Szpytma, M, Watson, D (Flinders Medical Centre), Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, Gj, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M (Gold Coast University Hospital), Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N (John Hunter Hospital), Elliott M, Phung D (Lifehouse), Phan D, Townend D (Lismore Base Hospital), Bong C, Gundara J (Logan Hospital), Frankel, A (Princess Alexandra Hospital), Bowman S, Guerra GR (Queen Elizabeth Ii Jubilee Hospital), Bolt, J, Buddingh, K, Dudi-Venkata, Nn, Jog, S, Kroon, Hm, Sammour, T, Smith, R, Stranz, C (Royal Adelaide Hospital), Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B (Royal Brisbane And Women&#8217, s Hospital), Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, Mw, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Austria: Lanner M (Kardinal Schwarzenberg Klinikum), Wright G (St Vincent&#8217, s Hospital)., K&#246, nigsrainer, I (Landeskrankenhaus Feldkirch), Bauer, M, Freyschlag, C, Kafka, M, Messner, F, 214, fner, D, Tsibulak, I (Medical University Of Innsbruck), Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, hlberger, L, Presl, J, Azerbaijan: Namazov &#304, Wimmer A (Paracelsus Medical University Salzburg)., Barbados: Barker D, Samadov E (Leyla Medical Centerl)., Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O&#8217, Shea, M, Padmore, G, Paquette, N, Phillips, E, John S, St., Belgium: Flamey N, Walkes K (Queen Elizabeth Hospital)., Pattyn, P (Az Delta), Oosterlinck, W, Van den Eynde, J, Brazil: Gatti A, Van den Eynde R (Uz Leuven)., Nardi, C, Oliva, R (Hospital Geral De Pirajussara), De Cicco, R (Instituto De C&#226, ncer Dr Arnaldo Vieira De Carvalho), Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Canada: Kidane B, Terra RM (Instituto Do C&#226, ncer De Estado De S&#227, o Paulo). Bulgaria: Sokolov M (University Hospital Alexandrovska)., Srinathan, S (Health Sciences Centre), Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S (Jewish General Hospital), Dumitra, S, Kouyoumdjian, A (Mcgill University Health Center), Johnston B, Russell C (Saint John Regional Hospital), Demyttenaere, S, Mary&#8217, s Hospital), Garfinkle R (St., Abou-Khalil, J, Nessim, C, Colombia: Almeciga A, Stevenson J (The Ottawa Hospital). Chile: Heredia F (Cl&#237, nica Universitaria De Concepci&#243, n)., Fletcher, A, Merchan A (Centro De Investigaciones Oncol&#243, gicas Cl&#237, nica San Diego, - Ciosad), Puentes LO (Hospital San Jos&#233, Croatia: Ba&#269, i&#263, G, Mendoza Quevedo J (Subred Sur Occidente De Kennedy (Hospital De Kennedy))., Karlovi&#263, D, Kr&#353, ul, D, Zeli&#263, M (University Hospital Center Rijeka), Luksic I, Mamic M (University Hospital Dubrava), Bakmaz, B, 262, oza, I, Dijan, E, Katusic, Z, Mihanovic, J, Cyprus: Frantzeskou K, Rakvin I (Zadar General Hospital)., Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Czechia: Martinek L, Yiallourou A (Nicosia General Hospital)., Skrovina, M, Szubota, I (Hospital &amp, amp, Oncological Centre Novy Jicin), 381, ateck&#253, J (Slezsk&#225, Nemocnice V Opav&#283, P. o. ), Javurkova, V, Denmark: Avlund T, Klat J (University Hospital Ostrava)., Christensen, P, Harbjerg, Jl, Iversen, Lh, Kjaer, Dw, Kristensen, H&#248, Mekhael, M (Aarhus University Hospital), Ebbeh&#248, j, Al, Krarup, P, Schlesinger, N, Egypt: Abdelsamed A, Smith H (Bispebjerg Hospital)., Azzam, Ay, Salem, H, Seleim, A (Al Azhar University Hospitals), Abdelmajeed, A, Abdou, M, Abosamak, Ne, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, Elqasabi, Ms, Elsayed Hewalla ME, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, Ms, Ragab, M, Sabry, A, Saifeldin, H, Saleh Mesbah Mohamed Elkaffas, M, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K (Alexandria Main University Hospital), Attia, D, Kamal, N, Osman, N (Alexandria Medical Research Institute), Abbas, Am, Abd Elazeem HAS, Abdelkarem, Mm, Alaa, S, Ali, Ak, Ayman, A, Azizeldine, Mg, Elkhayat, H, elghazaly S, M., Monib, Fa, Nageh, Ma, Saad, Mm, Salah, M, Shahine, M, Yousof, Ea, Youssef, A (Assiut University Hospital), Eldaly, A (El-Menshawy Hospital), ElFiky, M, Nabil, A (Kasr Alainy Faculty Of Medicine, Cairo, University), Amira, G, Sallam, I, Sherief, M, Sherif, A (Misr Cancer Center), Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G (National Cancer Institute), Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif AE (National Liver Institute, Finland: Kauppila J, Menoufia University). Ethiopia: Bekele D (Maddawalabu University Goba Referral Hospital)., Sarjanoja, E (L&#228, nsi-Pohja Central Hospital), Helminen, O, Huhta, H, France: Beyrne C, Kauppila JH (Oulu University Hospital)., Jouffret, L, Lugans, L, Marie-Macron, L (Centre Hospitalier Avignon), Chouillard E, De Simone B (Centre Hospitalier Intercommunal Poissy Saint Germain En Laye), Bettoni, J, Dakp&#233, S, Devauchelle, B, Lavagen, N, Testelin, S (Chu Amiens), Boucher, S, Breheret, R, Gueutier, A, Kahn, A, K&#252, n-Darbois, J (Chu Angers), Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P (Chu Besan&#231, on), Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, Fr, Truant, S, Zerbib, P (Chu Lille), Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J (Chu Limoges), Bergeat D, Merdrignac A (Chu Rennes - General Surgery), Le Roy, B, Perotto, Lo, Scalabre, A (Chu Saint Etienne), Aim&#233, A, Ezanno, A, Malgras, B (Hia Begin), Bouche P, Tzedakis S (H&#244, pital Cochin - Aphp), Cotte, E, Glehen, O, Lifante, J (Hopital Lyon Sud), D&#8217, Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B (Hus, Pole H&#233, pato-Digestif, / Ihu- Strasbourg), Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-givelet, A, Tribillon, E (Institut Mutualiste Montsouris), Duchalais, E, Espitalier, F, Ferron, C, Germany: Bork U, Malard O (Nantes University Hospital)., Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P (Carl-Gustav-Carus University, Dresden), Tu, Beyer, K, Kamphues, C, Lauscher, J, Loch, Fn, Schineis, C (Charit&#233, University Medicine, Campus Benjamin Franklin), Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J (Department of General, Visceral and Transplantation Surgery, Ludwig- Maximilians-Universitat Munich), Becker R, Jonescheit J (Heilig-Geist Hospital Bensheim), Pergolini I, Reim D (Klinikum Rechts Der Isar Tum School Of Medicine), Boeker, C, Hakami, I, Mall, J (Krh Nordstadt-Siloah Hospitals), Liokatis P, Smolka W (LMU Klinikum Campus Innenstadt), Nowak K, Reinhard T (Romed Klinikum Rosenheim), H&#246, lzle, F, Modabber, A, Winnand, P (University Hospital Aachen), Knitschke, M (University Hospital Giessen And Marburg), Kauffmann P, Wolfer S (University Hospital Goettingen / Universit&#228, tsmedizin Goettingen), Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R (University Hospital Halle (Saale)), Bertolani, E, nigsrainer, A, L&#246, ffler, Mw, Quante, M, Steidle, C, 220, berr&#252, ck, L, Yurttas, C (University Hospital Tuebingen), Betz, Cs, Bewarder, J, B&#246, ttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, Klatte, To, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, Uzunoglu, Fg, Vollkommer, T, Zeller, N (University Medical Center Hamburg- Eppendorf), Battista, Mj, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R (University Of Mainz, Greece: Angelou K, Department Of Gynaecology And Obstetrics)., Haidopoulos, D, Rodolakis, A (Alexandra General Hospital), Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A (Aretaieion Hospital), Antonopoulou, Mi, Manatakis, Dk, Tasis, N (Athens Naval And Veterans Hospital), Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P (Attikon University General Hospital), Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G (Evaggelismos General Hospital), Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, Ntziovara, Am, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S (General Hospital Of Larissa &#8220, Koutlimpaneio And Triantafylleio&#8221, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D (General University Hospital Of Larissa), Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G (George Papanikolaou General Hospital Of Thessaloniki), Karaitianos I, Tsirlis T (Henry Dunant Hospital Center), Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C (Laiko University Hospital), Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D (Papageorgiou General Hospital), Athanasakis, E, Chrysos, E, Tsiaousis, J, Xenaki, S, Hong Kong: Futaba K, Xynos E (University Hospital Of Heraklion Crete And Interclinic Hospital Of Crete)., Ho, Mf, Hon, Sf, Mak, Twc, Ng SSM (Prince Of Wales Hospital), Hungary: Banky B, Foo CC (Queen Mary Hospital)., Ireland: Aremu M, Suszt&#225, k N (Szent Borb&#225, la K&#243, rh&#225, z)., Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L (Connolly Hospital Blanchardstown), Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, Brien, S, Leary, P, Syed, Was, Vernon, L (Cork University Hospital), Callanan, D, Huang, L, Ionescu, A, Sheahan, P (South Infirmary Victoria University Hospital), Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, McCartan, D, McDermott, Ew, Prichard, Rs, Winter, D (St Vincent&#8217, s University Hospital), Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, Em, Donlon, N, Donohue, C, Fahey, Ba, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, Jo, Lennon, P, Maguire, Pj, Mccormick, P, Mehigan, Bj, Mohan, H, Nugent, T, Sullivan, H, Ravi, N, Reynolds, Jv, Rogers, A, Shokuhi, P, Smith, J, Smith, La, James&#8217, s Hospital), Timon C (St., Bashir, Y, Bass, G, Connelly, T, Earley, H, Elliott, Ja, Gillis, A, Kavanagh, D, Neary, P, riordan, J, Reynolds, Is, Rice, D, Ridgway, P, Umair, M, Whelan, M (Tallaght Hospital), Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nizami, K, Ryan, &#201, Samy, A (University Hospital Galway), Coffey, Jc, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S (University Hospital Limerick), Hardy, N, Malley, S, Italy: Macina S (Asst Mantua), Ryan M (University Hospital Waterford/University College Cork)., Mariani, Nm, Opocher, E, Pisani Ceretti A (Asst Santi Paolo, E Carlo), Ferrari, F, Odicino, F, Sartori, E (Asst Spedali Civili, Ospedale Di Brescia), Cotsoglou C, Granieri S (Asst Vimercate), Bianco, F, Camillo&#8217, Colledan, M, Tornese, S, Zambelli MF (Asst-Papa Giovanni Xxiii- Bergamo), Bissolotti, G, Fusetti, S, Lemma, F (Azienda Ospedaliera Di Padova), Marino, M, Mirabella, A, Vaccarella, G (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo), Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, Mn, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R (Azienda Ospedaliera Universitaria Careggi), Bassi, C, Campagnaro, T, Casetti, L, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M (Azienda Ospedaliera Universitaria Integrata Di Verona), Bellora, P, Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H (Azienda Ospedaliero Universitaria Maggiore Della Carit&#224, Bianchini, M, Chiarugi, M, Coccolini, F, Di Franco, G, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D (Azienda Ospedaliero Universitaria Pisana), Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, Sibilla, Mg, Urbani, A (Azienda Ospedaliero Universitaria Sant&#8217, anna), Fabbri, N, Feo, Cv, Gennari, S, Parini, S, Righini E (Azienda Unit&#224, Sanitaria Locale di Ferrara, - University of Ferrara), Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, Angelo, G, Lanfranco, D, Musini, L, Poli, T, Santoro, Gp, Varazzani, A (Azienda Ospedaliero-Universitaria Di Parma), Aguzzoli, L, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, Mandato, Vd, Mastrofilippo, V, Montella, Mt, Annessi, V, Zizzo M (Azienda Unit&#224, Sanitaria Locale, - Irccs Di Reggio Emilia), Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G (Ca&#8217, Foncello Treviso-DISCOG-Universit Di Padova), Esposito, G, Frongia, F, Pisanu, A, Podda, M (Cagliari University Hospital), Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M (Centro Di Riferimento Oncologico Di Aviano (Cro) Irccs), Bussu, F, Carta, Ag, Cossu, Ml, Cottu, P, Fancellu, A, Feo, Cf, Ginesu, Gc, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, Scanu, Am, Tedde, A, Tedde, M (Cliniche San Pietro, Sassari), A. o. u., Delrio, P, Rega D (Colorectal Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale-I. r. c. c. s., ), Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F (Department Of Surgical, University Of Palermo), Oncological And Oral Sciences., Calabr&#242, M, Farnesi, F, Lunghi, Eg, Muratore, A, Pipitone Federico NS (Edoardo Agnelli), B&#224, mbina, F, Andrea, G, Familiari, P, Picotti, V (Fabrizio Spaziani), De Palma, G, Luglio, G, Pagano, G, Tropeano FP (Federico Ii University Hospital), Baldari, L, Beltramini, Ga, Boni, L, Cassinotti, E, Gianni&#8217, Pignataro, L, Torretta S (Fondazione Irccs Ca&#8217, Granda, - Ospedale Maggiore Policlinico), Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, Comini, Lv, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L (Fondazione Irccs Istituto Nazionale Dei Tumori, Milano), Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, Amore, A, Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, Lombardi, Cp, Lorenzon, L, Marra, Aa, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R (Fondazione Policlinico Universitario Agostino Gemelli), Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone R (Hpb Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale- I. r. c. c. s., ), Carrano, Fm, Carvello, Mm, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G (Humanitas Clinical And Research Center Irccs, Rozzano (Mi) &amp, Humanitas, University, Department Of Biomedical Sciences, Pieve Emanuele (Mi)), Donati, Dm, Frisoni, T, Palmerini, E (Irccs Istituto Ortopedico Rizzoli), Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M (Irccs Ospedale Policlinico San Martino), Asti, E, Bernardi, D, Bonavina, L, Lovece, A (University of Milan, IRCCS Policlinico San Donato), Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue M (Istituto Europeo Di Oncologia, - Irccs -Milano), Badellino, E, Ferrero, A, Massobrio, R (Mauriziano Hospital Torino, Italy), De Manzoni Garberini, A (Ospedale Civile Spirito Santo), Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A (Ospedale Del Mare), Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo A (Ospedale Di Circolo, E Fondazione Macchi (Varese)), Baldi, C, Corbellini, C, Sampietro GM (Ospedale Di Rho, - Asst Rhodense), Cellerino P (Ospedale Fatebenefratelli, E Oftalmico), Baldini, E, Capelli, P, Isolani, Sm, Ribolla, M (Ospedale Guglielmo Da Saliceto Piacenza), Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A (Ospedale Luigi Sacco Milano), Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P (Ospedale Maggiore Di Lodi), Baietti, Am, Biasini, M, Maremonti, P, Neri, F, Prucher, Gm, Ricci, S, Ruggiero, F, Zarabini AG (Ospedale Maggiore/Bellaria Carlo Alberto Pizzardi Ausl Bologna), Barmasse, R, Mochet, S, Usai, A (Ospedale Regionale Umberto Parini), Leonardo - Asl Napoli 3 Sud, Incollingo P (Ospedale S., Castellammare Di Stabia), Mancini, S, Marino Cosentino, L, Sagnotta, A (Ospedale San Filippo Neri), Fruscio, R, Grassi, T, Nespoli, Lc, Tamini, N (Ospedale San Gerardo), Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A (Ospedale San Giovanni Di Dio), Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo M (Ospedale Vittorio Emanuele Iii, - Carate Brianza), Arminio, A, Cotoia, A, Lizzi, V, Vovola, F (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia), Vergari, R (Ospedali Riuniti Di Ancona), Ugo, S, Depalma, N, 8220, Vito Fazzi&#8221, Spampinato MG (P. o., Bartolucci, P, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, Cicerchia, Pm, Cirillo, B, De Toma, G, Di bartolomeo, A, Fiori, E, Fonsi, Gb, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, Scafa, Ak, Simonelli, L, Zambon M (Policlinico Umberto, I Sapienza University Of Rome), Capolupo, Gt, Carannante, F, Caricato, M, Mascian&#224, G, Mazzotta, E (Policlinico Universitario Campus Bio Medico Of Rome), Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E (Regina Montis Regalis Hospital, Mondov&#236, Cervellera, M, Gori, A, Sartarelli, L, orsola-Malpighi Hospital), Tonini V (S., Giacometti, M, Zonta, S (Ospedale San Biagio, Asl, VCO), Chessa, A, Fiorini, A, Norcini, C (San Giovanni Di Dio), Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M (San Leopoldo Mandic), Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Ottolina, J, Parise, P, Piloni, M, Sileri, P, Vignali, A (San Raffaele Scientific Institute, Milan), Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Dondi, G, Frio, F, Jovine, E, Mineo Bianchi, F, Neri, J, Parlanti, D, Perrone, Am, Pezzuto, Ap, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Schiavina, R, Serenari, M, Serra, M, Solli, P, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S (Sant&#8217, orsola Hospital, Alma Mater Studiorum University Of Bologna, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, Giuffrida, Mc, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Testa V (Santa Croce, E Carle Hospital, Cuneo), Agresta, F, Prando, D, Zese M (Santa Maria Degli Angeli Hospital Ulss5, - Adria), Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, Santonocito OS (Spedali Riuniti Di Livorno), Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Moritz Hospital), Scotton G (St., Fulginiti, Sf, Gallo, G, Sammarco, G, Vescio, G (University &#8216, Magna Graecia&#8217, Of Catanzaro), Balercia, P, Catarzi, L, Consorti G (University Hospital Umberto, I Ancona), Di Marzo, F (Valtiberina), Japan: Daiko H, Fontana T (Vittorio Emanuele)., Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakatani, F, Oguma, J, Tanase, Y, Jordan: Al Abdallah M, Uno M (National Cancer Center Hospital)., Ayasra, F, Ayasra, Y, Qasem, A (Al-Basheer Hospital), Abu Za&#8217, nouneh FJ, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K (King Abdullah University Hospital), Abdel Al, S, Abdel Jalil, R, Abou Chaar MK, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Libya: Alkadeeki G (Al-Jalaa Hospital), Lataifeh I (King Hussein Cancer Center)., Aldokali, N, Senossi, O, Subhi MT (Alkhadra Hospital), Burgan, D, Kamoka, E, Kilani, Ai, Salamah, A, Salem, M, Shuwayyah, A (National Cancer Institute, Sabratha, - Libya), Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M (Tripoli Central Hospital), Aldayri, Z, Ellojli, I, Lithuania: Bradulskis S, Kredan A (Tripoli University Hospital)., Dainius, E, Kubiliute, E, Kutkevi&#269, ius, J, Parseliunas, A, Subocius, A, Madagascar: Rasoaherinomenjanahary F, Venskutonis D (Lithuanian University Of Health Sciences Kaunas Clinical Hospital)., Razafindrahita, Jb, Malaysia: Ong EC (Bintulu), Samison LH (Joseph Ravoahangy Andrianavalona Hospital)., Hamdan, Kh, Ibrahim, Mr, Tan, Ja, Thanapal MR (Hospital Kuala Lumpur), Amin Sahid, N, Hayati, F, Jayasilan, J, Sriram, Rk, Subramaniam, S (Queen Elizabeth Hospital &amp, Universiti Malaysia Sabah, Kota, Kinabalu, Sabah, Malaysia), Che Jusoh, A, Hussain, Ah, Mohamed Sidek AS, Mohd Yunus MF, Soh, Jy, Wong, Mpk, Zakaria, Ad, Zakaria, Z (School Of Medical Sciences &amp, Hospital, Universiti Sains Malaysia), Fadzli, A, Fathi, Nq, Koh, Ps, Liew, Yt, Roslani, Ac, Tang, Cy, Teoh, Ly, Wong, Wj, Mexico: Alvarez MR, Yahaya AS (University Malaya Medical Centre)., Arrangoiz, R, Cordera, F, De la Rosa Abaroa MA, G&#243, mez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, Posada JA (Abc Medical Center), Becerra Garc&#237, a FC (Hospital San &#193, ngel Inn Chapultepec), Alfaro-Goldaracena, A, Buerba, Ga, Castillejos- Molina RA, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, M&#225, Oropeza- Aguilar, M, Pe&#241, a G&#243, mez Portugal, E, Posadas-Trujillo, Oe, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Morocco: Arkha Y, Vilatoba M (Instituto Nacional De Ciencias M&#233, dicas Y Nutrici&#243, n &#8220, Salvador Zubir&#225, n&#8221, Bechri, H, El Ouahabi, A, Oudrhiri MY (Centre Hospitalier Universitaire Ibn Sina Rabat), Derkaoui hassani F, El abbadi N (Cheikh Zaid International University Hospital), Amrani, L, Belkhadir, Zh, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, Majbar, Am, Mohsine, R, Netherlands: Hompes R, Souadka A (Institut National D&#8217, oncologie)., Meima-van Praag, E, Pronk, Ajm, Sharabiany, S (Amsterdam Umc, University Of Amsterdam), Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W (Antoni Van Leeuwenhoek Ziekenhuis), Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P (Gelre Ziekenhuis), Posma-Bouman, L (Slingeland Ziekenhuis), Derksen, T, Franken, J, Oosterling, S (Spaarne Gasthuis), De Bree, R (University Medical Center Utrecht), Konsten, J, Nigeria: Fidelis L, Van Heinsbergen M (Viecuri Medisch Centrum)., Sholadoye, Tt, Tolani, M (Ahmadu Bello University Teaching Hospital), Olaogun, J (Ekiti State University Teaching Hospital), Egbuchulem, Ik, Lawal, Ta, Ogundoyin, O, Olulana DI (University College Hospital), Abdur-Rahman, L, Adeyeye, A, Aremu, I, Bello, J, Olasehinde, O, Oman: Massoud J, Popoola A (University Of Ilorin Teaching Hospital)., Massoud, R, Pakistan: Jamal A, Sorour TM (Khoula Hospital)., Kerawala AA (Cancer Foundation Hospital), Memon, As, Nafees Ahmed, R, Pfau Civil Hospital), Rai L (Dr Ruth K. m., Ayub, B, Hassan, N, Martins, Rs, Ramesh, P, Sayyed, R (Patel Hospital), Butt, U, Kashif, M, Khan, Wh, Qureshi, A, Umar, M, Waris Farooka, M, Wasim, T (Services Hospital Lahore), Ayubi, A, Rashid, I, Peru: Falcon GM, Waqar SH (The Pakistan Institute Of Medical Sciences)., Philippines: Jocson R, Robles R (Instituto Regional De Enfermedades Neopl&#225, sicas Del Sur)., Teh, C (National Kidney &amp, Poland: Major P (Jagiellonian University Medical College), Transplant Institute)., Bobi&#324, ski, M, Kotarski, J, Rasoul-Peli&#324, ska, K (Medical University Of Lublin, Portugal: Azevedo C, Chair And Department Of Gynaecological Oncology And Gynaecology)., Machado, D, Mendes, F (Centro Hospitalar Cova Da Beira), De Sousa, X (Centro Hospitalar De Set&#250, bal), Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Mar&#231, al, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira B (Centro Hospitalar De Tr&#225, s-Os-Montes, E Alto Douro, E. p. e., ), Almeida, Ji, Correia de S&#225, T, Costa, Mjma, Fernandes, V, Ferraz, I, Gil, Cg, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Reis, R, Ribeiro, A, Santos, R, Saraiva, P, Silva, R, Tavares, F, Teixeira M (Centro Hospitalar Do Tamega, E Sousa), Almeida, Ac, Amaral, Mj, Andrade, R, Athayde Nem&#233, sio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, De Oliveira L&#243, pez AL, Duque, M, Garrido, S, Guerreiro, P, Guimar&#227, es, A, L&#225, zaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, Oliveira, Jm, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Sim&#245, es, J, Valente da Costa A (Centro Hospitalar, E Universit&#225, rio De Coimbra), Almeida, A, Cavaleiro, S, Devezas, V, Faria, Cs, J&#225, come, F, Magalh&#227, es Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira P (Centro Hospitalar, E Universit&#225, rio De S&#227, o Jo&#227, Gomes da Costa A, Lobo Antunes I (Centro Hospitalar Lisboa Norte), Pinto J, Tojal A (Centro Hospitalar Tondela-Viseu), Cardoso, N, Cardoso, P, Domingues, Jc, Henriques, P, Manso, Mi, Martins dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, Ribeiro, Vi, Soares, A, Sousa, S, Teixeira J (Centro Hospitalar Universit&#225, rio Do Algarve, - Unidade De Faro), Amorim, E, Baptista, Vh, Cunha, Mf, Dias, B, Fazenda, A, Melo Neves JP, Policarpo, F, Sampaio da N&#243, voa Gomes Miguel II, Veiga D (Centro Hospitalar Universitario Do Algarve, - Unidade De Portim&#227, Andrade, Ak, Bandovas, Jp, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Maciel, J, Pina, S, Rodrigues, A, Silva, N, Silveira Nunes, I, Sousa, R (Centro Hospitalar Universit&#225, rio Lisboa Central), Ascens&#227, o, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Louren&#231, o, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M (Hospital Beatriz Angelo), Azevedo J (Hospital Da Horta, E. p. e. ), Galv&#227, o, D, Soares, Ac, Vieira, A, Vieira, B (Hospital De Santo Espirito Da Ilha Terceira), Patr&#237, cio, B, Santos, Pmdd, Vieira Paiva Lopes AC (Hospital De Torres Vedras, - Centro Hospitalar Do Oeste), Cunha, R, Faustino, A, Freitas, A, Martins, Ab, Mendes, Jr, Parreira, R, Rosa, J, Teves, M (Hospital Do Divino Esp&#237, rito Santo), Abreu da Silva, A, Claro, M, Costa Santos, D, Deus, Ac, Grilo JV (Hospital Do Litoral Alentejano), Borges, F, Corte Real, J, Henriques, S, Lima, Mj, Matos Costa, P (Hospital Garcia De Orta), Brito da Silva, F, Caiado, A, Fonseca, F (Instituto Portugu&#234, s De Oncologia De Lisboa Francisco Gentil), 194, ngelo, M, Baiao, Jm, Martins Jord&#227, Vieira Caro&#231, o, T (Ipo Coimbra), Messias, J, Millan, A, Salgado, I, Santos, P (Ipo Lisboa), Ba&#237, a, C, Canotilho, R, Correia, Am, Ferreira Pinto AP, Peyroteo, M, Puerto Rico: Escobar P, Videira JF (Ipo Porto)., R&#233, union: Kassir R, Maldonado Santiago M (Instituto Gineco Oncologico)., Romania: Bezede C, Sauvat F (Chu Reunion)., Chitul, A, Ciofic, E, Cristian, D, Grama, F (Coltea Clinical Hospital), Pirtea L, Secosan C (Emergency Clinical City Hospital), Bonci, E, Gata, V, Ion Chiricuta Institute Of Oncology), Titu S (Prof. Dr., Ginghina, O, Iordache, N, Russia: Garmanova T, Iosifescu RV (Saint John Emergency Hospital)., Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I (Clinic Of Coloproctology And Minimally Invasive Surgery, Sechenov Medical State University), Litvina, Y, Provozina, A (Immanuel Kant Baltic Federal University, Regional Clinical Hospital), Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, 1050, 1072, 1084, 1083, 1086, 1074, &#1040, (Moscow Research And Educational Center, Saudi Arabia: Alshahrani M, Lomonosov Moscow State University)., Alsharif, F, Eskander, M (Aseer Central Hospital), Al Raddadi, R, Majrashi, S, Mashat, A (East Jeddah General Hospital), Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Saleem, A, Samkari, A, Trabulsi, N (King Abdulaziz University Hospital), Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said bayazeed, A (King Fahad General Hospital), Alhefdhi, A, Almalik, O, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S (King Faisal Specialist Hospital), Al Habes, H, Alamri, A, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Cort&#233, s Guiral, D, Elawad, A (King Khalid Hospital), AlAamer, O, Alriyees, L, Alselaim, N (King Saud Bin Abdulaziz University For Health Sciences, King Abdullah International Medical Research Center, Ministry Of National Guard, Health, Affairs, General Surgery Department., ), Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, Rabah, Pd, Serbia: Paunovic I, Zubaidi A (King Saud University)., Slijepcevic, N (Centre For Endocrine Surgery, Clinical Centre Of Serbia), Aleksi&#263, L, Antic, A, Barisic, G, Ceranic, M, Galun, D, Gruba&#269, &#381, Jelenkovic, J, Kecmanovi&#263, Kmezi&#263, Knezevic, D, Krivokapic, Z, Latin&#269, Markovic, V, Mati&#263, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Tadic, B, Vasljevi&#263, J, Velickovic, D, Zivanovic, M (Clinic For Digestive Surgery, Perovic M, Srbinovic L (Clinic For Gynecology And Obstetrics Narodni Front), Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z (Clinic For Gynecology And Obstetrics, Clinical Center Of Serbia), Antic, S, Dun&#273, erovi&#263, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazi&#263, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V (Clinic For Maxillofacial Surgery, School Of Dental Medicine, University Of Belgrade), Bascarevic, V, Bogdanovi&#263, I, Gruji&#269, Ilic, R, Mili&#263, evi&#263, Milisavljevi&#263, F, Miljkovi&#263, Paunovic, A, 352, 263, epanovi&#263, V, Stanimirovic, A, Todorovic, M (Clinic For Neurosurgery, Jotic, A, Milovanovic, J, Trivic, A (Clinic For Otorhinolaryngology And Maxillofacial Surgery, Bumbasirevic, U, Dzamic, Z, Kajmakovi&#263, B, Prijovi&#263, N, Zivkovic, M (Clinic Of Urology, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanovi&#263, Nikolic, S, Pejnovic, L, Savkovi&#263, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M (Institute For Oncology And Radiology Of Serbia), Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Singapore: Chan CW, Milutinovi&#263, V (Zvezdara University Medical Center)., Slovakia: G&#225, lis B, Lieske B (National University Hospital)., South Africa: Almgla N, &#352, imko K (University Hospital Bratislava)., Bernon, M, Boutall, A, Cairncross, L, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Van Wyngaard, T, Spain: Casta&#241, o-Leon AM, Vogel J (Groote Schuur Hospital)., Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno- Gomez, L, Paredes, I, P&#233, rez N&#250, 241, ez, A, S&#225, nchez Aniceto, G, Santas, M (12 De Octubre University Hospital), Fern&#225, ndez Rodr&#237, guez, P, Paniagua Garc&#237, a Se&#241, orans, M, Sanchez- Santos, R, Vigorita, V (&#193, lvaro Cunqueiro Hospital), Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, Vives RV (Bellvitge University Hospital), Escol&#224, D, Jim&#233, nez A (Comarcal Alt Pened&#233, Cayetano Paniagua L, G&#243, mez Fern&#225, ndez L (Consorci Sanitari De Terrassa), Artigues, E, Bernal-Sprekelsen, Jc, Catal&#225, Bauset JC (Consorcio Hospital General Universitario), Collera, P, Diaz Del Gobbo, R, Farre Font, R, Flores Clotet, R, mez D&#237, az CJ, Gu&#224, rdia, N, Guariglia, Ca, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos C (Fundaci&#243, Althaia, - Xarxa Assistencial Universit&#224, ria De Manresa), Albi Martin B, Garc&#237, a Villayz&#225, n JE (Fundaci&#243, n Jimenez Diaz University Hospital), Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, a-Quijada, J, Huertas Fernandez MA, Jimenez Miram&#243, n, J, Jimenez, V, Jover, Jm, Landeo Ag&#252, ero SA, Leon, R, Mart&#237, n Salamanca MB, rez Sim&#243, n, V, Ponce, S, Rodriguez, Jl, Salazar, A, Valle Rubio, A (Getafe University Hospital), Aguado, H (Hell&#237, n Hospital), Aldecoa Ansorregui, I, Bravo Infante, R, De Lacy FB, Di Somma, A, D&#237, az-Feijoo, B, Ense&#241, at Nora, J, Fabregas, N, Ferr&#233, s, A, Gil Iba&#241, ez, B, Gonzalez Sanchez JJ, Gracia, I, Hoyos Castro JA, Lacy, Am, Langdon, C, Mombl&#225, n, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, Reyes Figueroa LA, Roldan Ramos, P, Rumia-Arboix, J, Tercero-Uribe, Ai, Topczewski, Te, Torales, J, Torne, A, Torn&#233, R, Turrado-Rodriguez, V, Valero, R, Valverde, S (Hospital Clinic Barcelona), Anula, R, Cano-Valderrama, O, Del Campo Mart&#237, n, M, ez-Valladares, L, Dom&#237, nguez, I, Dziakova, J, a Alonso, M, a Romero, E, mez Latorre, L, Muguerza, Jm, Pizarro, Mj, Saez Carlin, P, nchez del Pueblo, C, nchez-Pernaute, A, Sanz Ortega, G, Sanz-Lopez, R, Torres, A (Hospital Cl&#237, nico De Madrid), Garc&#233, s-Albir, M, Lopez, F, n-Ar&#233, valo, J, Moro-Valdezate, D, Pla-Marti, V (Hospital Cl&#237, nico Universitario De Valencia), Beltr&#225, n de Heredia, J, De Andr&#233, s Asenjo, B, mez Sanz, T, Jezieniecki, C, Nu&#241, ez Del Barrio, H, Ortiz de Sol&#243, rzano Aurusa FJ, Romero de Diego, A, Ruiz Soriano, M, Trujillo D&#237, az, J, Vazquez fernandez, A (Hospital Cl&#237, nico Universitario De Valladolid), Lora-Cumplido P, Sosa MV (Hospital De Cabue&#241, es), Gonzalez-Gonzalez E, Minaya Bravo AM (Hospital Del Henares), Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, Espinosa, Ca, Jimenez Toscano, M, L&#243, pez Campillo, A, Mancebo, G, Martorell, P, Munarriz, M (Hospital Del Mar), Grau-Talens EJ, Martin-Perez B (Hospital Don Benito-Villanueva), Benavides Buleje JA, Carrasco Prats, M, ndez, Pv, ndez-L&#243, pez, A, a Escudero, D, a Porcel VJ, Garcia Soria, V, Gim&#233, nez Franc&#233, s, C, Gonz&#225, lez Valverde FM, Gurrea, E, pez-Morales, P, Marco Garrido, A, nez Alonso JA, Medina, E, Mu&#241, oz Camarena JM, Parra Ba&#241, os PA, a Ros, E, Ramirez Faraco, M, Ruiz-Mar&#237, Sanchez Rodriguez, C, Valero Soriano, M (Hospital General Reina Sof&#237, Estaire G&#243, mez, M, ndez Camu&#241, as, &#193, Garcia Santos EP, Jimenez Higuera, E, nez-Pinedo, C, oz-Atienza, V, Padilla-Valverde, D, Pic&#243, n Rodr&#237, guez, R, Redondo Calvo FJ, nchez-Garc&#237, a, S, Sanchez-Pelaez, D (Hospital General Universitario De Ciudad Real), Colombari, Rc, Del valle, E, ndez, M, Lozano Lominchar, P, n, L, Rey Valcarcel, C, Steiner, Ma, Tudela, M, Zorrilla Ort&#250, zar, J (Hospital General Universitario Gregorio Mara&#241, 243, Alcaide Matas, F, a P&#233, rez JM, Troncoso Pereira, P (Hospital Mateu Orfila), Mora-Guzm&#225, n, I (Hospital Santa B&#225, rbara), Abell&#225, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafr&#233, R (Hospital Universitari De Tarragona Joan Xxiii), Cavall&#233, Busquets, P, Gavalda Pellice MGP, Salinas Pe&#241, a, J (Hospital Universitari Sant Joan), Aragon Achig EJ, Barbier, L, Caja Vivancos, P, Gainza, A, a Gutierrez JJ, Mallabiabarrena Ormaechea, G, Mar&#237, n, H, Martin Playa, P, Melchor Corc&#243, stegui, I, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I (Hospital Universitario Cruces), De Andres Olabarria, U, Dur&#225, n Ballesteros, M, ndez Pablos FJ, Ib&#225, ez-Aguirre, Fj, Sanz Larrainzar, A, Ugarte-Sierra, B (Hospital Universitario De Galdakao), De la Hoz Rodr&#237, guez, &#193, Di Martino, M, a Septiem, J, Martin-Perez, E, oz de Nova JL (Hospital Universitario De La Princesa), Calvo Espino P, Guillamot Ruano P (Hospital Universitario De M&#243, stoles), Colao Garc&#237, a, L, az P&#233, rez, D, Esteban Agust&#237, E, Galindo Jara, P, Gutierrez Samaniego, M, Hernandez Bartolome MA, Serrano Gonz&#225, lez, J (Hospital Universitario De Torrej&#243, n De Ardoz), Alonso Poza, A, Di&#233, guez, B, a-Conde, M, Hern&#225, ndez-Garc&#237, a, M, Losada, M (Hospital Universitario Del Sureste), Chiesa-Estomba, Cm, lez Garc&#237, a J&#193, Larruscain, E, Sistiaga-Su&#225, rez JA (Hospital Universitario Donostia), Alvarez, E, Chavarrias, N, Fr&#237, as, L, a Pineda, V, Geg&#250, ndez Sim&#243, n, A, Gort&#225, zar, S, Gracia, M, Guevara, J, ndez Gutierrez, A, Loayza, A, a Dolores DT, C, Melendez, M, Moreno-Palacios, E, Perez, Y, Prieto Nieto MI, Ramos- Mart&#237, n, P, Rubio-Perez, I, Saavedra, J, Sanchez-Mendez, Ji, Siegrist Ridruejo, J, Urbieta, A, Zapardiel, I (Hospital Universitario La Paz), Cantalejo diaz, M, De Miguel Ardevines MDC, Duque-Mall&#233, Gascon Ferrer, I, lez-Nicol&#225, s Tr&#233, bol MT, Gracia-Roche, C, Herrero Lopez, M, Jariod Ferrer UM, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, nchez Fuentes, N, nchez-Rubio, M, Santero-Ramirez, Ms, Saud&#237, Sim&#243, n Sanz MV, Uson-Bouthelier, T (Hospital Universitario Miguel Servet), Blazquez Martin, A, Diez Alonso, M, a Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C (Hospital Universitario Principe De Asturias), Acebes Garc&#237, a, F, Bail&#243, Bueno Ca&#241, ones AD, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco S&#225, nchez, D, rez-Saborido, B, Sanchez Gonzalez, J, Tejero-Pintor FJ (Hospital Universitario R&#237, o Hortega), Alconchel, F, Conesa, A, Gil Mart&#237, nez, J, Guti&#233, rrez Fern&#225, ndez AI, Lopez Abad, A, Nicol&#225, s-L&#243, pez, T, Ramirez Romero, P, Roca Calvo MJ, Rodrigues, K, Ruiz Manzanera JJ, Soriano AI (Hospital Universitario Virgen De La Arrixaca), Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, rez S&#225, nchez MA, R&#237, o Lafuente FD, Torres Arcos, C, Valdes-Hernandez, J (Hospital Universitario Virgen Macarena), Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, nez Chicote, C, Sancho-Muriel J (Hospital Universitario, Y Polit&#233, cnico La Fe), Landaluce-olavarria A, Lecumberri D (Hospital Urduliz), Abad Gurumeta, A, Abad-Motos, A, nez-Hurtado, E, Ripoll&#233, s-Melchor, J, Ruiz Escobar, A (Infanta Leonor University Hospital), Cuadrado- Garc&#237, a, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Mat&#233, P, Ortega V&#225, zquez, I, Picardo, Al, Rojo L&#243, pez JA, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D (Infanta Sof&#237, a University Hospital), Anchuelo Latorre, J, Cagigas Fernandez, C, Cai&#241, a Ruiz, R, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, nez-P&#233, rez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V (Marqu&#233, s De Valdecilla University Hospital), Moliner-S&#225, nchez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I (Rey Juan Carlos University Hospital), Blas Laina JL, Cros, B, Escartin, J, Garcia Egea, J, Nogu&#233, Talal El-Abur, I, Y&#225, nez, C (Royo Villanova), Cagigal Ortega EP, Cervera, I, az Pe&#241, a, P, Elena, Gdcr, Enjuto, D, ndez Bernab&#233, s Garc&#237, a, R, Gonzalez, J, ndez, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodr&#237, guez G&#243, mez, L (Severo Ochoa University Hospital), Besc&#243, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo Garc&#237, a-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt L&#243, pez de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Sri Lanka: Arulanantham A, Saez barba M (Vall D&#8217, hebron University Hospital)., Bandara, Gbk, Jayarajah, U, Ravindrakumar, S, Rodrigo VS (District General Hospital Chilaw), Srishankar S (Teaching Hospital Anuradhapura). Sudan: Ali karar AA (Al-Rajhi). Sweden: Elbe P, Lindqvist EK (Karolinska University Hospital), Taflin, H (Sahlgrenska University Hospital), 196, lg&#229, Heinius, G, Nordberg, M, Pieniowski, E (South General Hospital), Gkekas, I, fgren, N, Ruteg&#229, rd, M, Switzerland: Arigoni M, Sund M (Umea University Hospital)., Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F (Ente Ospedaliero Cantonale), Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M (Hopital De Pourtales), Klenke, F, Koll&#224, r, A, Kurze, C (Inselspital, Bern University Hospital, University Of Bern), Adamina, M, B&#228, chler, T, Crugnale, As, Giardini, M, Guglielmetti, L, Peros, G, Turkey: Aghayeva A, Solimene F (Kantonsspital Winterthur)., Hamzaoglu, I, Sahin, I (Acibadem Altunizade Hospital), Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, D&#252, lgero&#287, lu, O, Ozben, V, Ozmen, Bb, Uras, C (Acibadem Atakent Hospital), Arikan, Ae, Bilgin, Ia, Bozk&#305, rl&#305, Ceyhan, Go, Kara, H, Karahasano&#287, lu, T, Uras, C (Acibadem Maslak Hospital), Celik, H (Adana Baskent University), Meydanli MM (Ankara City Hospital), Akilli, H, Ayhan, A, Kuscu, E (Baskent University), Onan MA (Gazi University Medical Faculty Hospital), Akgor, U, Dincer, Ha, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, Salman, Mc, Soyak, B (Hacettepe University Hospital), Alhamed, A, Erg&#252, n, S, OZcel&#305, k, Mf, Sanli, An, Uluda&#287, Velidedeoglu, M, Zengin AK (Istanbul Universty, - Cerrahpa&#351, a Medical Faculty), Bozkurt, Ma, Kara, Y, Kocata&#351, A (Kanuni Sultan Suleyman Training And Research Hospital), Cimenoglu, B, Demirhan, R, Lutfi Kirdar Training And Research Hospital), Saracoglu K (Kartal Dr., Azamat, I&#775, f, Balik, E, Bu&#287, ra, D, Giray, B, Kulle, Cb, Taskiran, C, Vatansever, D (Ko&#231, University Medical School), G&#246, zal, K, G&#252, ler, Sa, ken, H, Tatar, Oc, Utkan, Nz, Y&#305, ld&#305, r&#305, m, A, Y&#252, ksel, E (Kocaeli University Teaching Hospital), Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, 199, apo&#287, lu, R, elebi, F, Demir, H, Dikicier, E, Firat, N, n&#252, ll&#252, Kamburo&#287, lu, Mb, Kocer, B, 231, 252, k, If, Mantoglu, B (Sakarya University Faculty Of Medicine), olak, E, Kucuk, Go, Uyanik MS (Samsun Training And Research Hospital), 304, lhan Varank Training And Research Hospital), G&#246, ksoy B (Sehit Prof. dr., Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G (Sisli Hamidiye Etfal Training And Research Hospital), Akalin, M, Arican, C, Avci, Ek, Aydin, C, Demirli At&#305, c&#305, Emiroglu, M, Kaya, T, Kebab&#231, 305, Kilinc, G, Kirmizi, Y, 287, c&#252, H, Salimo&#287, lu, S, Sert, I&#775, Tugmen, C, Tuncer, K, Uslu, G, Ye&#351, ilyurt, D (University Of Health Sciences Tepecik Training And Research Hospital), Karaman, E, Kolusar&#305, A (Van Yuzuncu Yil University, Medical, Faculty), Uganda: Benson O, Yildiz A (Yildirim Beyazit University Yenimahalle Training And Research Hospital)., United Kingdom: Agilinko J, Lule H (Kampala International University Teaching Hospital)., Ahmeidat, A, Barabasz, M, Bekheit, M, Cheung, Lk, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, Kamera, Bs, Mignot, G, Shaikh, S, Sharma, P (Aberdeen Royal Infirmary), Abu-Nayla, I, Agrawal, A, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, Davies, Rj, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Khan, Dz, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, Mitrofan, Cg, Mohan, M, Morris, A, Murphy, S, Neill, R, Price, S, Pushpa-rajah, J, Raby-Smith, W, Ramzi, J, Rooney, S, Santarius, T, Singh, A, Stewart, Gd, Tan, Xs, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S (Addenbrooke&#8217, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Pringle, S, Schache, A, Shaw, R, Sheel, A (Aintree University Hospital), Rossborough, C (Altnagelvin Area Hospital), Angelou, D, Choynowski, M, McAree, B, McCanny, A, Neely, D (Antrim Area Hospital- Northern Health And Social Care Trust), Tutoveanu, G (Barnsley Hospital Nhs Foundation Trust), Ahad, S, De La Cruz Monroy MFI, Mosley, F, Oktseloglou, V (Bradford Royal Infirmary), Alanbuki, A, Patel, M, Shabana, A (Brighton And Sussex Nhs Trust, Princess Royal Hospital), Perera, E, Raveendran, D, Ravi- Shankar, K, Thiruchelvam, J (Broomfield Hospital), Arrowsmith L, Campbell W (Causeway Hospital), Grove, T, Kontovounisios, C, Warren, O (Chelsea And Westminster Hospital), Rolland, P (Cheltenham General Hospital), Aggarwal, A, Brown, S, Jelley, C, Neal, N (Churchill Hospital), Clifford, R, Eardley, N, Krishnan, E, Manu, N, Martin, E, Roy Mahapatra, S, Serevina, Ol, Smith, C, Vimalachandran, D (Countess Of Chester Hospital), Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H (Cumberland Infirmary), Emslie, K, Labib, Pl, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L (Derriford Hospital), Abubakar, A, Akhter Rahman MM, Kyk, Ko, Brien, H, Sasapu, K, Woodun, H (Diana Princess Of Wales Hospital Grimsby), Inglis R, Ng HJ (Dumfries And Galloway Royal Infirmary), De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shrestha, D, Sultana, A, Taggarsi, M, Timbrell, S, Vaz, Op, Vitone, L (East Lancashire Hospitals Nhs Trust), Day, A, Dent, H, Fahim, M, Waheed, S (East Surrey Hospital), Hunt A, Laskar N (East Sussex Healthcare (Conquest Hospital And Eastbourne District General Hospital)), Gupta, A, Steinke, J, Thrumurthy, S (Epsom &amp, St Helier University Hospitals Nhs Trust), Massie, E, McGivern, K, Rutherford, D, Wilson, M (Forth Valley Royal Hospital), Hardie J, Kazzaz S (Frimley Health Nhs Ft - Frimley Park), Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S (Furness General Hospital), Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, McCormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R (Gateshead Health Nhs Foundation Trust), Kretzmer, L, Lalou, L, Manku, B, Parwaiz, I, Stafford, J (George Eliot Hospital), Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G (Glan Clwyd Hospital), Ang, K, Caruana, Ej, Chowdhry, Mf, Mohammad, A, Nakas, A, Rathinam, S (Glenfield Hospital), Boal, M, Brown, O, Dwerryhouse, S, Higgs, S, Vallance, A (Gloucestershire Royal Hospital), Boyd, E, Irvine, V, Kirk, A (Golden Jubilee National Hospital), Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M (Good Hope Hospital), Agoston, P, Bill&#232, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A (Guy&#8217, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Jawad, Z, Jiao, L, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D (Hammersmith Hospital), Laws, S (Hampshire Hospitals Nhs Trust), Hardie C, McNaught C (Harrogate District Hospital), Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A (Heartlands Hospital), Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S (Homerton University Hospital), Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, Akw, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Langstroth, M, Loubani, M, McMillan, A, Nazir, S, Qadri, Ssa, Robinson, A, Ross, E, Sehgal, T, Wilkins, A (Hull University Teaching Hospitals Nhs Trust), Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Lester, S, Madhavan, A, Thulasiraman, Sv, Viswanath, Y (James Cook University Hospital), Curl-Roper, T, Delimpalta, C, Liao, Ccl, Velchuru, V, Westwood, E (James Paget Univeristy Nhs Foundation Trust Hospital), Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, 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H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De Simone, B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., El amrani, M., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. R., Truant, S., Zerbib, P., Ballouhey, Q., Barrat, B., Laloze, J., Salle, H., Taibi, A., Usseglio, J., Bergeat, D., Merdrignac, A., Le Roy, B., Perotto, L. O., Scalabre, A., Aime, A., Ezanno, A., Malgras, B., Bouche, P., Tzedakis, S., Cotte, E., Glehen, O., Kepenekian, V., Lifante, J., Passot, G., D'Urso, A., Felli, E., Mutter, D., Pessaux, P., Seeliger, B., Bardet, J., Berry, R., Boddaert, G., Bonnet, S., Brian, E., Denet, C., Fuks, D., Gossot, D., Grigoroiu, M., Laforest, A., Levy-Zauberman, Y., Louis-Sylvestre, C., Moumen, A., Pourcher, G., Seguin-Givelet, A., Tribillon, E., Duchalais, E., Espitalier, F., Ferron, C., Malard, O., Bork, U., Distler, M., Fritzmann, J., Kirchberg, J., Praetorius, C., Riediger, C., Weitz, J., Welsch, T., Wimberger, P., Beyer, K., Kamphues, C., Lauscher, J., Loch, F. N., Schineis, C., Albertsmeier, M., Angele, M., Kappenberger, A., Niess, H., Schiergens, T., Werner, J., Becker, R., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Liokatis, P., Smolka, W., Nowak, K., Reinhard, T., Holzle, F., Modabber, A., Winnand, P., Knitschke, M., Kauffmann, P., Wolfer, S., Kleeff, J., Lorenz, K., Michalski, C., Ronellenfitsch, U., Schneider, R., Bertolani, E., Konigsrainer, A., Loffler, M. W., Quante, M., Steidle, C., Uberruck, L., Yurttas, C., Betz, C. S., Bewarder, J., Bottcher, A., Burg, S., Busch, C., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Koenig, D., Moeckelmann, N., Nitschke, C., Priemel, M., Smeets, R., Speth, U., Thole, S., Uzunoglu, F. G., Vollkommer, T., Zeller, N., Battista, M. J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I., Diamantis, A., Gkrinia, E., Hajiioannou, J., Korais, C., Koukoura, O., Perivoliotis, K., Saratziotis, A., Skoulakis, C., Symeonidis, D., Tepetes, K., Tzovaras, G., Zacharoulis, D., Alexoudi, V., Antoniades, K., Astreidis, I., Christidis, P., Deligiannidis, D., Grivas, T., Ioannidis, O., Kalaitsidou, I., Loutzidou, L., Mantevas, A., Michailidou, D., Paraskevopoulos, K., Politis, S., Stavroglou, A., Tatsis, D., Tilaveridis, I., Vahtsevanos, K., Venetis, G., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Mpaili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Anthoulakis, C., Christou, C., Papadopoulos, V., Tooulias, A., Tsolakidis, D., Tsoulfas, G., Zouzoulas, D., Athanasakis, E., Chrysos, E., Tsiaoussis, J., Xenaki, S., Xynos, E., Futaba, K., Ho, M. F., Hon, S. F., Mak, T. W. C., Ng, S. S. M., Foo, C. C., Banky, B., Susztak, N., Aremu, M., Canas-Martinez, A., Cullivan, O., Murphy, C., Owens, P., Pickett, L., Akmenkalne, L., Byrne, J., Corrigan, M., Cullinane, C., Daly, A., Fleming, C., Jordan, P., Killeen, S., Lynch, N., Mccarthy, A., Mustafa, H., O'Brien, S., O'Leary, P., Syed, W. A. S., Vernon, L., Callanan, D., Huang, L., Ionescu, A., Sheahan, P., Balasubramanian, I., Boland, M., Conlon, K., Evoy, D., Fearon, N., Gallagher, T., Geraghty, J., Heneghan, H., Kennedy, N., Maguire, D., Mccartan, D., Mcdermott, E. W., Prichard, R. S., Winter, D., Alazawi, D., Barry, C., Boyle, T., Butt, W., Connolly, E. M., Donlon, N., Donohue, C., Fahey, B. A., Farrell, R., Fitzgerald, C., Kinsella, J., Larkin, J. O., Lennon, P., Maguire, P. J., Mccormick, P., Mehigan, B. J., Nugent, T., O'Sullivan, H., Ravi, N., Reynolds, J. V., Rogers, A., Shokuhi, P., Smith, J., Smith, L. A., Timon, C., Bashir, Y., Bass, G., Connelly, T., Creavin, B., Earley, H., Elliott, J. A., Gillis, A., Kavanagh, D., Neary, P., O'Riordan, J., Reynolds, I. S., Rice, D., Ridgway, P., Umair, M., Whelan, M., Carroll, P., Collins, C., Corless, K., Finnegan, L., Fowler, A., Hogan, A., Kerin, M., Lowery, A., Mcanena, P., Mckevitt, K., Nizami, K., Ryan, E., Samy, A., Coffey, J. C., Cunningham, R., Devine, M., Nally, D., Peirce, C., Tormey, S., Hardy, N., O'Malley, S., Ryan, M., Macina, S., Mariani, N. M., Opocher, E., Pisani Ceretti, A., Ferrari, F., Odicino, F., Sartori, E., Cotsoglou, C., Granieri, S., Bianco, F., Camillo, A., Colledan, M., Tornese, S., Zambelli, M. F., Bissolotti, G., Fusetti, S., Lemma, F., Marino, M. V., Mirabella, A., Vaccarella, G., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Tucci, R., Bassi, C., Bortolasi, L., Campagnaro, T., Casetti, L., De Pastena, M., Esposito, A., Fontana, M., Guglielmi, A., Landoni, L., Malleo, G., Marchegiani, G., Nobile, S., Paiella, S., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Salvia, R., Turri, G., Tuveri, M., Bellora, P., D'Aloisio, G., Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva Radica, M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Ampollini, L., Bellanti, L., Bergonzani, M., Bertoli, G., Bocchialini, G., D'Angelo, G., Lanfranco, D., Musini, L., Poli, T., Santoro, G. P., Varazzani, A., Aguzzoli, L., Borgonovo, G., Castro Ruiz, C., Coiro, S., Falco, G., Mandato, V. D., Mastrofilippo, V., Montella, M. T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Gronchi, A., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Fagotti, A., Gasparini, G., Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, C., Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spinelli, A., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli Romario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di bartolomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Lippa, L., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Gallo, G., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi Kato, M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, F., Ayasra, Y., Qasem, A., Abu Za'nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel Al, S., Abdel Jalil, R., Abou Chaar, M. K., Al-Masri, M., Al-Najjar, H., Alawneh, F., Alsaraireh, O., Elayyan, M., Ghanem, R., Lataifeh, I., Alkadeeki, G. Z., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin Sahid, N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che Jusoh, A., Hussain, A. H., Mohamed Sidek, A. S., Mohd Yunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Roslani, A. C., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De La Rosa Abaroa, M. A., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra Garcia, F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. A., Oropeza-Aguilar, M., Pena Gomez Portugal, E., Posadas-Trujillo, O. E., Rodriguez-Covarrubias, F., Salgado-Nesme, N., Vilatoba, M., Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M. Y., Derkaoui hassani, F., El Abbadi, N., Amrani, L., Belkhadir, Z. H., Benkabbou, A., Chakib, O., El Ahmadi, B., El Bouazizi, Y., Essangri, H., Ghannam, A., Majbar, A. M., Mohsine, R., Souadka, A., Hompes, R., Meima-Van Praag, E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Reijers, S., Van Houdt, W., Baaij, J., Bolster-Van Eenennaam, M., De Graaff, M., Sloothaak, D., Van Duijvendijk, P., Posma-Bouman, L., Derksen, T., Franken, J., Oosterling, S., De Bree, R., Konsten, J., Van Heinsbergen, M., Fidelis, L., Sholadoye, T. T., Tolani, M. A., Olaogun, J., Egbuchulem, I. K., Lawal, T. A., Ogundoyin, O., Olulana, D. I., Abdur-Rahman, L., Adeyeye, A., Aremu, I., Bello, J., Olasehinde, O., Popoola, A., Massoud, J., Massoud, R., Sorour, T. M., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees Ahmed, R., Rai, L., Ayub, B., Hassan, N., Martins, R. S., Ramesh, P., Sayyed, R., Butt, U., Kashif, M., Khan, W. H., Qureshi, A., Umar, M., Waris Farooka, M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Major, P., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz Pereira, R., Vieira, B., Almeida, J. I., Correia de Sa, T., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., Lima Da Silva, C., Lopes, L., Machado, N., Marialva, J., Nunes Coelho, M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athayde Nemesio, R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., De Barros, J., De Oliveira Lopez, A. L., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., Simoes, J., Valente Da Costa, A., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes Maia, M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., Gomes Da Costa, A., Lobo Antunes, I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., Martins Dos Santos, G., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Cunha, M. F., Dias, B., Fazenda, A., Melo Neves, J. P., Policarpo, F., Sampaio Da Novoa Gomes Miguel, I. I., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., Figueiredo De Barros, I., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira Nunes, I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre Pinto, A., Peralta Ferreira, M., Ribeiro, J., Rio Rodrigues, L., Sousa Fernandes, M., Azevedo, J., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira Paiva Lopes, A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., Abreu Da Silva, A., Claro, M., Costa Santos, D., Deus, A. C., Grilo, J. V., Borges, F., Corte Real, J., Henriques, S., Lima, M. J., Matos Costa, P., Brito da Silva, F., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins Jordao, D., Vieira Caroco, T., Messias, J., Millan, A., Salgado, I., Baia, C., Canotilho, R., Correia, A. M., Ferreira Pinto, A. P., Peyroteo, M., Videira, J. F., Escobar, P., Maldonado Santiago, M., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Garmanova, T., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Alshahrani, M., Alsharif, F., Eskander, M., Al Raddadi, R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Nasser, M., Said bayazeed, A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M., Abdelrahman, S., Althobaiti, W., Al Habes, H., Alamri, A., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes Guiral, D., Elawad, A., Alaamer, O., Alriyees, L., Alselaim, N., Abdulkareem, A., Ajlan, A., Akkour, K., Al-Habib, A., Al-Khayal, K., Alatar, A., Alburakan, A., Alhalal, H., Alhassan, B., Alhassan, N., Alobeed, O., Alsaif, A., Alsaif, F., Alshammari, S., Alshaygy, I., Barry, M., Bin Nasser, A., Bin Traiki, T., Bokhari, A., Elwatidy, S., Helmi, H., Madkhali, A., Nouh, T., Rabah, P. D., Zubaidi, A., Paunovic, I., Slijepcevic, N., Aleksic, L., Antic, A., Barisic, G., Ceranic, M., Galun, D., Grubac, Z., Jelenkovic, J., Kecmanovic, D., Kmezic, S., Knezevic, D., Krivokapic, Z., Latincic, S., Markovic, V., Matic, S., Miladinov, M., Pavlov, M., Pejovic, I., Radenkovic, D., Tadic, B., Vasljevic, J., Velickovic, D., Zivanovic, M., Perovic, M., Srbinovic, L., Andrijasevic, S., Bozanovic, T., Cerovic Popovic, R., Dokic, M., Janjic, T., Jeremic, K., Kadija, S., Ladjevic Likic, I., Mirkovic, L., Pantovic, S., Pilic, I., Radojevic, M., Stefanovic, A., Vidakovic, S., Vilendecic, Z., Antic, S., Dunderovic, D., Jelovac, D., Jezdic, Z., Konstantinovic, V., Kotlar, B., Kuzmanovic, C., Lazic, M., Petrovic, M., Popovic, F., Pucar, A., Romic, M., Sumrak, S., Vujanac, V., Bascarevic, V., Bogdanovic, I., Grujicic, D., Ilic, R., Milicevic, M., Milisavljevic, F., Miljkovic, A., Paunovic, A., Scepanovic, V., Stanimirovic, A., Todorovic, M., Jotic, A., Milovanovic, J., Trivic, A., Bumbasirevic, U., Dzamic, Z., Kajmakovic, B., Prijovic, N., Zivkovic, M., Buta, M., Cvetkovic, A., Djurisic, I., Gacic, S., Goran, M., Inic, Z., Jeftic, N., Jevric, M., Jokic, V., Markovic, I., Milanovic, M., Nikolic, S., Pejnovic, L., Savkovic, N., Spurnic, I., Stevic, D., Stojiljkovic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Milutinovic, V., Lieske, B., Galis, B., Simko, K., Almgla, N., Bernon, M., Boutall, A., Cairncross, L., Herman, A., Hilton, T., Jonas, E., Kloppers, C., Malherbe, F., Mugla, W., Nel, D., Rayamajhi, S., Van Wyngaard, T., Vogel, J., Castano-Leon, A. M., Delgado Fernandez, J., Eiriz Fernandez, C., Espino Segura-Illa, M., Esteban Sinovas, O., Garcia Perez, D., Gomez, P., Jimenez-Roldan, L., Lagares, A., Moreno-Gomez, L., Paredes, I., Perez Nunez, A., Sanchez Aniceto, G., Santas, M., Fernandez Rodriguez, P., Paniagua Garcia Senorans, M., Sanchez-Santos, R., Vigorita, V., Acrich, E., Baena Sanfeliu, E., Barrios, O., Golda, T., Santanach, C., Serrano-Navidad, M., Sorribas Grifell, M., Vives, R. V., Escola, D., Jimenez, A., Cayetano Paniagua, L., Gomez Fernandez, L., Artigues, E., Bernal-Sprekelsen, J. C., Catala Bauset, J. C., Collera, P., Diaz Del Gobbo, R., Farre Font, R., Flores Clotet, R., Gomez Diaz, C. J., Guardia, N., Guariglia, C. A., Osorio, A., Sanchez Jimenez, R., Sanchon, L., Soto Montesinos, C., Albi Martin, B., Garcia Villayzan, J. E., Alonso-Lamberti, L., Assaf, M., Baeza Pintado, N., Carabias, A., Garcia-Quijada, J., Huertas Fernandez, M. A., Jimenez Miramon, J., Jimenez, V., Jover, J. M., Landeo Aguero, S. A., Leon, R., Martin Salamanca, M. B., Perez Simon, V., Ponce, S., Rodriguez, J. L., Salazar, A., Valle Rubio, A., Aguado, H., Aldecoa Ansorregui, I., Bravo Infante, R., De Lacy, F. B., Di Somma, A., Diaz-Feijoo, B., Ensenat Nora, J., Fabregas, N., Ferres, A., Gil Ibanez, B., Gonzalez Sanchez, J. J., Gracia, I., Hoyos Castro, J. A., Lacy, A. M., Langdon, C., Momblan, D., Morales, X., Oleaga, L., Otero, A., Pedrosa, L., Poblete Carrizo, J., Reyes Figueroa, L. A., Roldan Ramos, P., Rumia-Arboix, J., Tercero-Uribe, A. I., Topczewski, T. E., Torales, J., Torne, A., Torne, R., Turrado-Rodriguez, V., Valero, R., Valverde, S., Anula, R., Cano-Valderrama, O., Del Campo Martin, M., Diez-Valladares, L., Dominguez, I., Dziakova, J., Garcia Alonso, M., Garcia Romero, E., Gomez Latorre, L., Muguerza, J. M., Pizarro, M. J., Saez Carlin, P., Sanchez Del Pueblo, C., Sanchez-Pernaute, A., Sanz Ortega, G., Sanz-Lopez, R., Torres, A., Garces-Albir, M., Lopez, F., Martin-Arevalo, J., Moro-Valdezate, D., Pla-Marti, V., Beltran De Heredia, J., De Andres Asenjo, B., Gomez Sanz, T., Jezieniecki, C., Nunez Del Barrio, H., Ortiz De Solorzano Aurusa, F. J., Romero De Diego, A., Ruiz Soriano, M., Trujillo Diaz, J., Vazquez Fernandez, A., Lora-Cumplido, P., Sosa, M. V., Gonzalez-Gonzalez, E., Minaya Bravo, A. M., Alonso de la Fuente, N., Cazador Labat, M., Cecchini, L., Espinosa, C. A., Jimenez Toscano, M., Lopez Campillo, A., Mancebo, G., Martorell, P., Munarriz, M., Grau-Talens, E. J., Martin-Perez, B., Benavides Buleje, J. A., Carrasco Prats, M., Fernandez, P. V., Fernandez-Lopez, A., Garcia Escudero, D., Garcia Porcel, V. J., Garcia Soria, V., Gimenez Frances, C., Gonzalez Valverde, F. M., Gurrea, E., Lopez-Morales, P., Marco Garrido, A., Martinez Alonso, J. A., Medina, E., Munoz Camarena, J. M., Parra Banos, P. A., Pena Ros, E., Ramirez Faraco, M., Ruiz-Marin, M., Sanchez Rodriguez, C., Valero Soriano, M., Estaire Gomez, M., Fernandez Camunas, A., Garcia Santos, E. P., Jimenez Higuera, E., Martinez-Pinedo, C., Munoz-Atienza, V., Padilla-Valverde, D., Picon Rodriguez, R., Redondo Calvo, F. J., Sanchez-Garcia, S., Sanchez-Pelaez, D., Colombari, R. C., Del valle, E., Fernandez, M., Lozano Lominchar, P., Rey Valcarcel, C., Steiner, M. A., Tudela, M., Zorrilla Ortuzar, J., Alcaide Matas, F., Garcia Perez, J. M., Troncoso Pereira, P., Mora-Guzman, I., Abellan, M., Achalandabaso Boira, M., Jorba, R., Memba Ikuga, R., Olona, C., Sales Mallafre, R., Cavalle Busquets, P., Gavalda Pellice, M. G. P., Salinas Pena, J., Aragon Achig, E. J., Barbier, L., Caja Vivancos, P., Gainza, A., Garcia Gutierrez, J. J., Mallabiabarrena Ormaechea, G., Marin, H., Martin Playa, P., Melchor Corcostegui, I., Prieto Calvo, M., Rodriguez Fraga, A., Villalabeitia Ateca, I., De Andres Olabarria, U., Duran Ballesteros, M., Fernandez Pablos, F. J., Ibanez-Aguirre, F. J., Sanz Larrainzar, A., Ugarte-Sierra, B., De La Hoz Rodriguez, A., Di Martino, M., Garcia Septiem, J., Martin-Perez, E., Munoz De Nova, J. L., Calvo Espino, P., Guillamot Ruano, P., Colao Garcia, L., Diaz Perez, D., Esteban Agusti, E., Galindo Jara, P., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Serrano Gonzalez, J., Alonso Poza, A., Dieguez, B., Garcia-Conde, M., Hernandez-Garcia, M., Losada, M., Chiesa-Estomba, C. M., Gonzalez Garcia, J. A., Larruscain, E., Sistiaga-Suarez, J. A., Alvarez, E., Chavarrias, N., Frias, L., Garcia Pineda, V., Gegundez Simon, A., Gortazar, S., Gracia, M., Guevara, J., Hernandez Gutierrez, A., Loayza, A., Maria Dolores, D. T., Marti, C., Melendez, M., Moreno-Palacios, E., Perez, Y., Prieto Nieto, M. I., Ramos-Martin, P., Rubio-Perez, I., Saavedra, J., Sanchez-Mendez, J. I., Siegrist Ridruejo, J., Urbieta, A., Zapardiel, I., Cantalejo diaz, M., De Miguel Ardevines, M. D. C., Duque-Mallen, V., Gascon Ferrer, I., Gonzalez-Nicolas Trebol, M. T., Gracia-Roche, C., Herrero Lopez, M., Jariod Ferrer, U. M., Lanzon, A., Martinez German, A., Matute, M., Redondo, C., Sanchez Fuentes, N., Sanchez-Rubio, M., Santero-Ramirez, M. S., Saudi, S., Simon Sanz, M. V., Uson-Bouthelier, T., Blazquez Martin, A., Diez Alonso, M., Garcia Rico, E., Garcia-Loarte Gomez, E., Garcia-Moreno Nisa, F., Gutierrez Calvo, A., Hernandez, P., Lasa, I., Mendoza-Moreno, F., Morales Palacios, N., Ovejero Merino, E., Vera Mansilla, C., Acebes Garcia, F., Bailon, M., Bueno Canones, A. D., Choolani Bhojwani, E., Marcos-Santos, P., Miguel, T., Pacheco Sanchez, D., Perez-Saborido, B., Sanchez Gonzalez, J., Tejero-Pintor, F. J., Alconchel, F., Conesa, A., Gil Martinez, J., Gutierrez Fernandez, A. I., Lopez Abad, A., Nicolas-Lopez, T., Ramirez Romero, P., Roca Calvo, M. J., Rodrigues, K., Ruiz Manzanera, J. J., Soriano, A. I., Cano, A., Capitan-Morales, L., Cintas Catena, J., Gomez-Rosado, J., Oliva Mompean, F., Perez Sanchez, M. A., Rio Lafuente, F. D., Torres Arcos, C., Valdes-Hernandez, J., Cholewa, H., Domingo, S., Frasson, M., Lago, V., Marina Martin, T., Martinez Chicote, C., Sancho-Muriel, J., Landaluce-Olavarria, A., Lecumberri, D., Abad Gurumeta, A., Abad-Motos, A., Martinez-Hurtado, E., Ripolles-Melchor, J., Ruiz Escobar, A., Cuadrado-Garcia, A., Garcia-Sancho Tellez, L., Heras Aznar, J., Mate, P., Ortega Vazquez, I., Picardo, A. L., Rojo Lopez, J. A., Sanchez Cabezudo Noguera, F., Serralta De Colsa, D., Anchuelo Latorre, J., Cagigas Fernandez, C., Caina Ruiz, R., Gomez Ruiz, M., Hernanz, F., Jimeno Fraile, J., Martinez-Perez, P., Poch, C., Santarrufina Martinez, S., Valbuena Jabares, V., Moliner-Sanchez, C., Pingarron-Martin, L., Rey-Biel, J., Ruiz Martin, I., Blas Laina, J. L., Cros, B., Escartin, J., Garcia Egea, J., Nogues, A., Talal El-Abur, I., Yanez, C., Cagigal Ortega, E. P., Cervera, I., Diaz Pena, P., Elena, G. D. C. R., Enjuto, D., Fernandez Bernabe, P., Garces Garcia, R., Gonzalez, J., Hernandez, I., Herrera-Merino, N., Marqueta De Salas, M., Martinez Pascual, P., Perez Gonzalez, M., Ramos Bonilla, A., Rodriguez Gomez, L., Bescos, C., Blanco-Colino, R., Brana, I., Caimari, B., De Pablo Garcia-Cuenca, A., Duran-Valles, F., Espin-Basany, E., Giralt Lopez De Sagredo, J., Pamias, J., Pellino, G., Prat, N., Pujol Pina, R., Saez Barba, M., Arulanantham, A., Bandara, G. B. K., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S., Srishankar, S., Ali Karar, A. A., Elbe, P., Lindqvist, E. K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Rutegard, M., Sund, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Adamina, M., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atici, S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Colquhoun, A., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Hutchinson, P., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Lamb, B., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Schache, A., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De La Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Marchbank, A., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Ang, K., Caruana, E. J., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Vallance, A., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Khan, T., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Fotopoulou, C., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Patel, A., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Wilkins, A., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani majd, H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Brunelli, A., Burke, J., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. 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D, Geddes, A, Mccaul, J, Mcmahon, J, H Khan, A, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, L Tan, K, Woodham, A, Adiamah, A, Brewer, H, Chowdhury, A, Evans, J, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D, Cool, P, Cribb, G, Shepherd, K, Bisset, C, Moug, S, Elson, N, Faulkner, G, Saleh, P, Underwood, C, Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R, Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, L Malcolm, F, Theophilidou, E, Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, Mcdermott, F, Mcgrath, J, Mclennan, A, Ng, M, Pascoe, J, Rajaretnam, N, Bulathsinhala, S, Davidson, B, Fusai, G, Hidalgo Salinas, C, Machairas, N, Pissanou, T, M Pollok, J, A Raptis, D, Soggiu, F, Tzerbinis, H, E Xyda, S, Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G, Al-Tamimi, Y, Bacon, A, Beasley, N, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Thompson, A, Varley, I, Drake, T, Harrison, E, Linder, G, Mayes, J, Mcgregor, R, Skipworth, R, Zamvar, V, Hawkin, P, Raymond, T, Ryska, O, Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, Mckinney, R, Mcnicol, F, Russ, J, Szatmary, P, R Tan, J, Thomas, A, Whelan, P, Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, D Jayasinghe, J, Knowles, C, Kocher, H, Leal Silva, I, S Ledesma, F, Minicozzi, A, Navaratne, L, Rahman, R, Ramamoorthy, R, Sohrabi, C, Thaha, M, Thakur, B, Venn, M, Yip, V, Baumber, R, Parry, J, Evans, S, Jeys, L, Morris, G, Parry, M, Ahmadi, N, Aresu, G, M Barrett-Brown, Z, S Coonar, A, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, S Pradeep, I, Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, Mcaleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I, Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D, Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, K Madhuri, T, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D, Aljanadi, F, Jones, M, Mhandu, P, O'Donnell, C, Turkington, R, Al-Ishaq, Z, Bhasin, S, S Bodla, A, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Pickford, S, Rahman, E, Snee, D, Vidya, R, Yassin, N, Fountain, D, T Hasan, M, Karabatsou, K, Laurente, R, Pathmanaban, O, Al-Mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R, Ethunandan, M, K Sekhon, G, Shields, H, Singh, R, Wensley, F, Lawday, S, Lyons, A, Abbott, T, Anwar, S, Ghufoor, K, Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Hall, J, Harris, G, James, G, Kang, C, J Lin, D, D Rajgor, A, Royle, T, Scurrah, R, Steel, B, J Watson, L, Choi, D, Hutchison, R, Jain, A, Luoma, V, Marcus, H, May, R, Menon, A, Pramodana, B, Webber, L, A Aneke, I, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, M, Millward, C, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, S Babar, M, Collard, B, Goodrum, S, Lau, K, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Elhamshary, A, Imam, Smb, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, Mcewen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Jones, Sef, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-Omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar AMcEvoy, K, Naredla, P, Robertson, S, Sait, M, R Sarma, D, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, A Akhtar, M, Brunt, A, Mcintyre, J, Milne, K, M Rashid, M, Sgro, A, E Stewart, K, Turnbull, A, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, Macdonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, S Kolli, V, K Lala, A, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Loehrer, A, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, Mcelhinney, K, Olson, K, C Osterberg, E, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, Dilalla, G, S Hwang, E, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, E Gabre-Kidan AJenny, H, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Ganly, I, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, S Oh, J, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, K Abel, M, Andaya, V, Bigay, K, A Boeck, M, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, Bc, Heaton, C, Hirose, K, M Jablons, D, Kirkwood, K, Z Kornblith, L, R Kratz, J, Lee, R, N Miller, P, Nakakura, E, Nunez-Garcia, B, O'Donnell, R, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, M, Wai, K, Wustrack, R, J Xu, M, Beswick, D, Goddard, J, Manor, J, Song, J, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, L Roland, C, N Zafar, S, Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M, Aoun, S, S Ban, V, H Batjer, H, Caruso, J, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Hawkins, A, Maiga, A, Laufer, J, Scasso, S, Surgery, Graduate School, Glasbey, J, Nepogodiev, D, Simoes, J, Omar, O, Li, E, Abou Chaar, M, Chaudhry, D, Videria, J, Gujjuri, R, Kaafarani, H, Minaya-Bravo, A, Mckay, S, Roberts, K, Miguel-Mendez, C, Smart, N, Stewart, G, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), COVIDSurg Collaborative, Kolias, Angelos [0000-0003-3992-0587], Stewart, Grant [0000-0003-3188-9140], Apollo - University of Cambridge Repository, Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA, COVIDSurg Collaborative, Palmerini Emanuela, Frisoni Tommaso, Donati Davide, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, V Tonini, M Cervellera, A Gori, L Sartarelli, Glasbey, James C, Simoes, Joana F F, Venn, Mary L, Pgdme, null, Abou Chaar, Mohammad K, Edwards, Jonathan G, Evans, Jonathan P, Videria, Jose Flavio, Ford, Samuel J, Griffiths, Ewen A, Gujjuri, Rohan R, Kolias, Angelos G, Kaafarani, Haytham M A, McKay, Siobhan C, Mohan, Helen M, Roberts, Keith J, Smart, Neil J, Stewart, Grant D, Sundar Mrcog, Sudha, and Bhangu, Aneel A, Toia, F

Subjects
Male, Cancer Research, Outcome Assessment, International Cooperation, Settore MED/18 - CHIRURGIA GENERALE, Settore MED/19 - Chirurgia Plastica, 030230 surgery, Aged, Aged, 80 and over, COVID-19, Cohort Studies, Critical Care, Elective Surgical Procedures, Epidemics, Female, Humans, Logistic Models, Middle Aged, Neoplasms, Outcome Assessment, Health Care, Postoperative Complications, SARS-CoV-2, 0302 clinical medicine, Operating theater, cohort studies, Health care, middle aged, 80 and over, Medicine, Lung, Cancer, COVID-19/epidemiology, OUTCOMES, Manchester Cancer Research Centre, Pulmonary Complication, ORIGINAL REPORTS, aged, Oncology, 030220 oncology & carcinogenesis, Pneumonia & Influenza, Patient Safety, Elective Surgical Procedure, Life Sciences & Biomedicine, 6.4 Surgery, Cohort study, Human, medicine.medical_specialty, elective surgical procedures/methods, Logistic Model, Health Care, Clinical Sciences, Oncology and Carcinogenesis, Epidemic, [SDV.CAN]Life Sciences [q-bio]/Cancer, cancer surgery, SARS-CoV-2 pandemic, epidemics, COVIDSurg Collaborative, NO, outcome assessment, health care/methods, 03 medical and health sciences, male, Settore MED/28 - Malattie Odontostomatologiche, Clinical Research, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Elective surgery, Elective Cancer Surgery in SARS-CoV-2, Elective Cancer Surgery in COVID-19, covid 19, sars-cov-2, Science & Technology, business.industry, Prevention, ResearchInstitutes_Networks_Beacons/mcrc, Evaluation of treatments and therapeutic interventions, 1103 Clinical Sciences, Pneumonia, Odds ratio, medicine.disease, Good Health and Well Being, neoplasms/surgery, critical care/methods, Emergency medicine, postoperative complications/prevention & control, Neoplasm, Postoperative Complication, Cohort Studie, business, aged, 80 and over, SARS-CoV-2/physiology, logistic models
Abstract

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks. Copyright © 2020 American Society of Clinical Oncology. All rights reserved. Bowel and Cancer Research; Sarcoma UK; Yorkshire Cancer Research; European Society of Coloproctology; National Institute for Health Research: 16.136.79; Bowel Disease Research Foundation; Urology Foundation Supported by a National Institute for Health Research (NIHR) Global Health Research Unit grant (NIHR 16.136.79) using UK aid from the UK government to support global health research, Association of Coloproctology of Great Britain and Ireland, Bowel & Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. The funders had no role in the study design; data collection, analysis, and interpretation; or writing of this report. The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR, or UK Department of Health and Social Care.

Published
2021

6. Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Author

Bhangu, A, Global variation in anastomosis and end colostomy formation following left-sided colorectal resection GlobalSurg Collaborative Appendix S1 Collaborators Authors (all the following are PubMed citable): Writing group: James, C Glasbey (UK), Adewale, O Adisa (Nigeria), Ainhoa Costas-Chavarri (Rwanda), Ahmad, U Qureshi (Pakistan), Jean, C Allen-Ingabire (Rwanda), Hosni Khairy Salem (Egypt), Anyomih Theophilus Teddy Kojo (Ghana), Stephen Tabiri (Ghana), Dmitri Nepogodiev (UK), Richard, J Lilford (UK), Ewen, M Harrison (UK), Thomas, D Pinkney (UK), Neil Smart (UK), Aneel Bhangu (UK, denotes joint first author Patient representatives: Azmina Verjee (UK), study guarantor)., Emmy Runigamugabo (Rwanda) Statistical analysis: James Glasbey, Aneel Bhangu Protocol development and project steering: Adesoji, O Ademuyiwa, Adewale, O Adisa, Maria Lorena Aguilera, Afnan, Altamini, Philip, Alexander, Sara, W Al-Saqqa, Giuliano, Borda-Luque, Jen, Cornick, Ainhoa, Costas-Chavarri, Thomas, M Drake, Stuart, J Fergusson, J Edward Fitzgerald, James, Glasbey, Allen Ingabire, J. C., Lawani, Ismaïl, Zahra, Jaffry, Hosni Khairy Salem, Chetan, Khatri, Andrew, Kirby, Anyomih Theophilus Teddy Kojo, Marie Carmela Lapitan, Richard, Lilford, Andre, L Mihaljevic, Midhun, Mohan, Dion, Morton, Alphonse Zeta Mutabazi, Dmitri, Nepogodiev, Faustin, Ntirenganya, Riinu, Ots, Francesco, Pata, Thomas, Pinkney, Tomas, Poškus, Ahmad Uzair Qureshi, Antonio Ramos-De la Medina, Sarah, Rayne, Gustavo, Recinos, Kjetil, Søreide, Catherine, A Shaw, Sebastian, Shu, Richard, Spence, Neil, Smart, Stephen, Tabiri, Ewen, M Harrison, Aneel Bhangu National leads (GlobalSurg-1) Lead coordinator, Australia, Neel Gobin, Brazil, Ana Vega Freitas, Canada, Nigel Hall, China, &amp, Hong Kong, Sung-Hee Kim, Egypt, Ahmed, Negida, Hosni, Khairy, England, Stephen, J Chapman, France, Alexis P Arnaud, Ghana, Stephen Tabiri, Guatemala, Gustavo Recinos, India, Cutting Edge Manipal, Indonesia, Radhian Amandito, Iraq, Marwan Shawki, Ireland, Michael Hanrahan, Italy, Francesco Pata, Lithuania, Justas Zilinskas, Malaysia, April Camilla Roslani, Cheng Chun Goh, Nigeria, Adesoji O Ademuyiwa, Northern Ireland, Gareth Irwin, Peru, Laura, Luque, Saudi, Arabia, Hunain, Shiwani, Afnan, Altamimi, Mohammed Ubaid Alsaggaf, Scotland, Stuart J Fergusson, South, Africa, Sri Lanka, Jenifa Jeyakumar, Sweden, Yucel Cengiz, Switzerland, Dmitri A Raptis, Wales, James, C Glasbey National leads (GlobalSurg-2) Argentina, Maria Marta Modolo, Australia, Dushyant, Iyer, Sebastian, King, Tom, Arthur, Bangladesh, Sayeda Nazmum Nahar, Barbados, Ade Waterman, Benin, Lawani Ismaïl, Botswana, Michael Walsh, Canada, Arnav, Agarwal, Augusto, Zani, Mohammed, Firdouse, Tyler, Rouse, China, Qinyang Liu, Colombia, Juan Camilo Correa, Egypt, Hosni Khairy Salem, Estonia, Peep Talving, Ethiopia, Mengistu Worku, France, Alexis Arnaud, Greece, Vassilis Kalles, Guatemala, Basant, Kumar, Sunil, Kumar, Ireland, Roy Quek, Italy, Luca, Ansaloni, Jordan, Ahmed Altibi, Lithuania, Donatas, Venskutonis, Justas, Zilinskas, Tomas, Poskus, Madagascar, John Whitaker, Malawi, Vanessa Msosa, Malaysia, Yong Yong Tew, Malta, Alexia, Farrugia, Elaine, Borg, Mexico, Antonio Ramos-De la Medina, Morocco, Zineb Bentounsi, Norway, Kjetil Søreide, Pakistan, Tanzeela Gala, Palestinian, Territory, Ibrahim, Al-Slaibi, Haya, Tahboub, Alser, Osaid H., Diego, Romani, Sebestian, Shu, Poland, Piotr Major, Romania, Aurel, Mironescu, Matei, Bratu, Amar, Kourdouli, Saint Kitts and Nevis, Aliyu Ndajiwo, Abdulaziz, Altwijri, Ahmad, Gudal, Al Faifi Jubran, Sierra Leone, Sam Seisay, Singapore, Bettina Lieske, Spain, Irene Ortega, Sri, Lanka, Jenifa, Jeyakumar, Senanayake, Kithsiri J., Sudan, Omar Abdulbagi, Switzerland, Dmitri Raptis, Turkey, Yuksel Altinel, United, Kingdom, Chia, Kong, Ella, Teasdale, Gareth, Irwin, Michael, Stoddart, Rakan, Kabariti, Sukrit, Suresh, United, States, Katherine, Gash, Ragavan, Narayanan, Zambia, Mayaba Maimbo Local collaborators (GlobalSurg-1) Argentina: Claudio Fermani, Ruben, Balmaceda, Australia: Ewan Macdermid, Maria Marta Modolo (Hospital Luis Lagomaggiore)., Neel, Gobin, Roxanne, Chenn, Cheryl Ou Yong, Michael Edye (Blacktown Hospital), Martin, Jarmin, Scott, K D'amours, Dushyant Iyer (Liverpool Hospital, The University Of New South Wales), Daniel, Youssef, Nicholas, Phillips, Jason Brown (Royal Brisbane &amp, Women'S, Hospital), Robert, George, Cherry, Koh, Oliver Warren (The Royal Prince Alfred Hospital, Australia), Isaac Hanley (The Tweed Hospital), Austria: Clemens Nawara, Marilla Dickfos (Toowoomba Hospital)., Dietmar, Öfner, Florian Primavesi (Department Of Surgery, Bangladesh: Ashrarur Rahman Mitul, Paracelsus Medical University Salzburg)., Khalid Mahmud (Dhaka Shishu (Children) Hospital), Margub, Hussain, Hafiz, Hakim, Tapan Kumar (Dhaka Medical College Hospital), Benin: Pamphile A Assouto, Antje Oosterkamp (Lamb Hospital)., Ismail, Lawani, Brunei: Aung Kyaw Tun, Yacoubou Imorou Souaibou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga)., Chean Leung Chong (Pmmpmhamb Hospital) Giridhar, H Devadasar, Chean Leung Chong, Muhammad Rashid Minhas Qadir (Ssb Hospital), Kyaw Phyo Aung, Lee Shi Yeo, Brazil: Vanessa Dina Palomino Castillo, Chean Leung Chong (Ripas Hospital)., Monique Moron Munhoz, Gisele Moreira (Conjunto Hospitalar De Sorocaba), Luiz Carlos Barros De Castro Segundo, Salim Anderson Khouri Ferreira, Maíra Cassa Careta (Hospital Da Santa Casa De Misericórdia De Vitória), Stella Binna Kim, Alexandre Venancio De Sousa, Alyne Daltri Lazzarini Cury (Hospital De Caridade Sãƒo De Paula), Gustavo Peixoto Soares Miguel, Ana Vega Carreiro De Freitas, Barbara Pereira Silvestre (Hospital Estadual Doutor Jayme Dos Santos Neves), Julia Guasti Pinto Vianna, Carolina Oliveira Felipe, Luis Alberto Valente Laufer (Hospital Estadual Doutor Jayme Santos Neves), Fernanda, Altoe, Luana Ayres Da Silva, Marina Luiza Pimenta, Thiago Fernandes Giuriato, Paulo Alves Bezerra Morais, Jessica Souza Luiz (Hospital Estadual Dr Jayme Santos Neves), Rafael, Araujo, Juliana, Menegussi, Marisa, Leal, Caio Vinícius Barroso de Lima, Luiza Sarmento Tatagiba, Antônio Leal (Hospital Infantil Nosa Senhora Da Gloria), Diogo Vinicius dos Santos, Gustavo Pereira Fraga, Romeo Lages Simoes (Hospital De Clinicas, Cameroon: Samuel Nigo, University Of Campinas). Cambodia: Simon Stock (World Mate Emergency Hospital)., Juana, Kabba, Tagang Ebogo Ngwa, Canada: Sebastian King, James Brown (Mbingo Baptist Hospital)., Georges, Azzie, Sameer, Kushwaha, Arnav Agarwal (The Hospital For Sick Children), Karen, Bailey, Brian, Cameron, Michael Livingston (McMaster Children's Hospital), Alexandre, Horobjowsky, Dan, L Deckelbaum, Tarek Razek (Centre for Global Surgery, Chile: Boris Marinkovic, McGill University Health Centre)., Eugenio, Grasset, Nicole D'aguzan (Hospital Del Salvador), Julio, Jimenez, China: Zhongtao Zhang, Roberto Macchiavello (Hospital Luis Tisne)., Wei, Guo, Junyeong, Oh, Colombia: Irene Montes, Fei Zheng (Beijing Friendship Hospital)., Sebastian, Sierra, Manuela Mendez (Clinica Ces), Maria Isabel Villegas, Maria Clara Mendoza Arango, Ivan Mendoza (Clinica Las Vegas), Fred Alexander Naranjo Aristizã¡bal, Jaime Andres Montoya Botero, Victor Manuel Quintero Riaza (Hospital Pablo Tobon Uribe), Jakeline, Restrepo, Carlos, Morales, Maria Clara Mendoza Arango (Hospital Universitario San Vicente Fundacion), Herman, Cruz, Alejandro, Munera, Croatia: Robert Karlo, Maria Clara Mendoza Arango (Ips Universitaria Clinica Leon Xiii)., Edgar, Domini, Jakov Mihanovic (Zadar General Hospital), Mihael, Radic, Kresimir, Zamarin, Dominican Republic: Manuel Hache-Marliere, Nikica Pezelj (General Hospital Sibenik)., Sylvia Batista Lemaire, Ruben Rivas (Cedimat, - Centro De Diagnostico Medicina Avanzada, Egypt: Ahmed Khyrallh, Laboratorio Y Telemedicina)., Ahamed, Hassan, Gamal, Shimy, Mohamed, A Baky Fahmy (Al-Azher Universty Hospital), Ayman, Nabawi, Mohamed, Elfil, Mohamed, Ghoneem, Muhammad El-Saied Ahmad Muhammad Gohar, Mohamed, Asal, Mostafa, Abdelkader, Mahmoud, Gomah, Hayssam, Rashwan, Mohamed, Karkeet, Ahmed Gomaa (Alexandria Main University Hospital), Amr, Hasan, Ahmed, Elgebaly, Omar, Saleh, Ahmad Abdel Fattah, Abdullah, Gouda, Abd Elrahman Elshafay, Abdalla, Gharib, Ahmed, Menshawy, Mohammed, Hanafy, Abdullah, Al-Mallah, Mahmoud, Abdulgawad, Mohamad, Baheeg, Mohammed, Alhendy, Ibrahim, Abdelfattah, Abdalla, Kenibar, Omar, Osman, Mostafa, Gemeah, Ahmed, Mohammed, Abdalrahman, Adel, Abdelrahman, Mohammed, Abdelrahman, Sayed, Mohamed Abozaid (Al-Hussein Hospital), Ahmed Hafez El-Badri Kotb, Ali Amin Ahmed Ata, Mohammed, Nasr, Abdelrahman, Alkammash, Mohammed, Saeed, Nader Abd El Hamid, Attia Mohamed Attia, Ahmed Abd El Galeel, Eslam, Elbanby, Khalid Salah El-Dien, Usama, Hantour, Omar, Alahmady, Billal, Mansour, Amr Muhammad Elkorashy (Bab El-Shareia Hospital), Emad Mohamed Saeed Taha, Kholod Tarek Lasheen, Salma Said Elkolaly, Nehal Yosri Elsayed Abdel-Wahab, Mahmoud Ahmed Fathi Abozyed, Ahmed, Adel, Ahmed Moustafa Saeed, Gehad Samir El Sayed, Jehad Hassan Youssif (Banha University Hospital), Soliman Magdy Ahmed, Nermeen Soubhy El-Shahat, Abd El-Rahman Hegazy Khedr (Belbes Central Hospital), Abdelrhman Osama Elsebaaye, Mohamed, Elzayat, Mohamed, Abdelraheim, Ibrahim, Elzayat, Mahmoud, Warda, Khaled Naser El Deen, Abdelrhman Essam Elnemr, Omar, Salah, Mohamed, Abbas, Mona, Rashad, Ibrahim, Elzayyat, Dalia, Hemeda, Gehad, Tawfik, Mai, Salama, Hazem, Khaled, Mohamed Seisa (El Dawly Hospital, - Mansoura), Kareem, Elshaer, Abdelfatah, Hussein, Mahmoud Elkhadrawi (El Mahalla General Hospital), Ahmed Mohamed Afifi, Osama Saadeldeen Ebrahim, Mahmoud Mohamed Metwally (El, - Mataria Educational Hospital), Rowida, Elmelegy, Diaa Moustafa Elbendary Elsawahly, Hisham, Safa, Eman, Nofal, Mohamed, Elbermawy, Ahmed Abdelmotaleb Ghazy, Hisham, Samih, Asmaa, Abdelgelil, Sarah, Abdelghany, Ahmed El Kholy, Metwally, Aboraya, Fatma, Elkady, Mahmoud, Salma, Sarah, Samy, Reem, Fakher, Aya, Aboarab, Ahmed, Samir, Ahmed, Sakr, Abdelrahman, Haroun, Asmaa Abdel-Rahman Al-Aarag, Ahmed, Elkholy, Sally Elshanwany (El-Menshawy Hospital), Esraa Ghanem (Elshohadaa Central Hospital), Ahmed, Tammam, Ali Mohamed Hammad, Yousra El Shoura, Gehad El Ashal, Hosni Khairy (Kasr Alainy School Of Medicine), Sarah, Antar, Sara, Mehrez, Mahmoud, Abdelshafy, Maha Gamal Mohamad Hamad, Mona, Hosh, Emad, Abdallah, Basma, Magdy, Thuraya, Alzayat, Elsayed, Gamaly, Hossam, Elfeki, Amany, Abouzahra, Shereen, Elsheikh, Fatimah, I Elgendy (Mansoura University Hospitals), Fathia Abd El-Salam, Osama, Seifelnasr, Mohamed, Ammar, Athar, Eysa, Aliaa, Sadek, Aliaa Gamal Toeema, Aly, Nasr, Mohamed, Abuseif, Hagar, Zidan, Sara Abd Elmageed Barakat, Nadin, Elsayed, Yasmin Abd Elrasoul, Ahmed, Elkelany, Mohamed Sabry Ammar, Mennat-Allah, Mustafa, Yasmin, Hegazy, Mohamed, Etman, Samar, Saad, Mahmoud, Alrahawy, Ahmed, Raslan, Mahmoud, Morsi, Ahmed, Rslan, Ahmed, Sabry, Hager, Elwakil, Heba, Shaker, Yasmin, Abd-Elrasoul, Ahmed Elkelany (Menoufia University Hospitals), Hussein, El-Kashef, Mohamed, Shaalan, Areej Tarek (Minia University Hospital), Ayman, Elwan, Ahmed Ragab Nayel, Mostafa, Seif, Doaa, Emadeldin, Mohamed Ali Ghonaim, Ahmad, Almallah, Ahmed, Fouad, Eman Adel Sayma (New Damietta University Hospital), Ahmad, Elbatahgy, Angham Solaiman El-Ma'doul, Ahmed, Mosad, Hager, Tolba, Diaa Eldin Abdelazeem Amin Elsorogy, Hassan Ali Mostafa, Amira Atef Omar, Ola Sherief Abd El Hameed, Ahmed Lasheen (Quweisna Central Hospital In Quweisna), Yasser Abd El Salam, Ashraf, Morsi, Mohammed Ismail (Ras El Tin General Hospital), Hager Ahmed El-badawy, Mohamed, A Amer, Ahmed Sabry El-Hamouly, Attallah, Noura A., Omnia, Mosalum, Ahmed, Afandy, Ahmed, Mokhtar, Alaa, Abouelnasr, Sara, Ayad, Ramdan, Shaker, Rokia, Sakr, Ramadan, Shaker, Mahmoud, Amreia, Soaad, Elsobky, Mohamed, Mustafa, Ahmed Abo El Magd, Abeer, Marey, Amr Tarek Hafez, Mohamed, F Zalabia (Shebin Elkom Teaching Hospital, Menoufia), Mohamed Moamen Mohamed, Amr, Fadel, Emad Ali Ahmed (Sohag University Hospital), Ahmad, Ali, Mohammad Ghassan Alwafai, Abdullah, Dwydar, Sara, Kharsa, Ehab, Mamdouh, Hatem, El-Sheemy, Ibrahim, Alyoussef, Abouelatta Khairy Aly, Ahmad, Aldalaq, Ehab, Alnawam, Dalia Alkhabbaz (Souad Kafafi University Hospital), Mahmoud, Saad, Shady, Hussein, Ahmed Abo Elazayem, Ahmed, Meshref, Marwa, Elashmawy, Mohammed, Mousa, Ahmad, Nashaat, Sara, Ghanem, Zaynab, M Elsayed, Aya, Elwaey, Iman Elkadsh (Suez Canal University Hospitals), Mariam, Darweesh, Ahmed, Mohameden, Mennaallah Hafez (Suez General Hospital), Ahmed, Badr, Assmaa, Badwy, Mohamed Abd El Slam (Talla Central Hospital), Mohamed, Elazoul, Safwat, Al-Nahrawi, Lotfy, Eldamaty, Fathee, Nada, Mohamed, Ameen, Aya, Hagar, Mohamed, Elsehimy, Mohammad, Aboraya, Hossam, Dawoud, Shorouk El Mesery, Abeer El Gendy, Ahmed, Abdelkareem, Ahmed Safwan Marey, Mostafa, Allam, Sherif, Shehata, Khaled, Abozeid, Marwa, Elshobary, Ahmed, Fahiem, Sameh, Sarsik, Amel, Hashish, Mohamed, Zidan, Mohamed, Hashish, Shaimaa, Aql, Abdelaziz Osman Abdelaziz Elhendawy (Tanta University Hospital), Mohamed, Husseini, Esraa, Kasem, Ahmed, Gheith, Yasmin, Elfouly, Ahmed Ragab Soliman, Yasmein, Ibrahim, Nesma, Elfouly, Ahmed, Fawzy, Ahmed, Hassan, Mohammad, Rashid, Abdallah Salah Elsherbiny, Basem, Sieda, Nermin, M Badwi, Mohammed Mustafa Hassan Mohammed, Osama, Mohamed, Ethiopia: Mengistu Worku, Mohammad Abdulkhalek Habeeb (Zagazig University Hospitals)., Nichole Starr (Dessie Referral Hospital), Semay, Desta, Sahlu, Wondimu, Nebyou Seyoum Abebe (Minilik Ii Hospital), Efeson, Thomas, Frehun Ayele Asele, Daniel Dabessa (Myungsung Christian Medical Center), Nebiyou Seyoum Abebe, Finland: Panu Mentula, Abebe Bekele Zerihun (Tikur Anbessa Hospital)., Ari, Leppäniemi, France: Aurelien Scalabre, Ville Sallinen (Helsinki University Central Hospital)., Fernanda, Frade, Sabine Irtan (Trousseau Hospital Sorbonnes Universités, Upmc Univ Paris), Vivien, Graffeille, Elodie, Gaignard, Quentin Alimi (Chu De Rennes), Quentin, Alimi, Vivien, Graffieille, Elodie Gaignard (Fr Rennes University), Olivier, Abbo, Sofia, Mouttalib, Ourdia Bouali (Hopital Des Enfants), Erik, Hervieux, Yves, Aigrain, Nathalie Botto (Hopital Necker Enfants Malades), Alice, Faure, Lucile, Fievet, Nicoleta Panait (Hopitâl Nord), Emilie, Eyssartier, Francoise, Schmitt, Guillaume Podevin (Pediatric Surgery Department, University Hospital Of Angers, France), Valentine, Parent, Amandine, Martin, Alexis Pierre Arnaud (Rennes University Hospital), Cecile, Muller, Arnaud, Bonnard, Ghana: Francis Abantanga, Matthieu Peycelon (Robert Debré Children University Hospital)., Kwaku, Boakye-Yiadom, Mohammed Bukari (Komfo Anokye Teaching Hospital), Frank Owusu (Offinso District Hospital), Joseph, Awuku-Asabre, Lemuel Davies Bray (University For Development Studies, School Of Medicine And Health Sciences, General Surgery Department, Greece: Dimitrios Lytras, Tamale Teaching Hospital)., Kyriakos, Psarianos, Anastasia Bamicha (Achillopoyleio General Hospital Of Volos), Eirini Kefalidi (Attikon General Hospital), Georgios Gemenetzis (Attikon University Hospital), Christos, Dervenis, Nikolaos, Gouvas, Christos Agalianos (Konstantopouleio General Hospital Of Athens), Michail, Kontos, Gregory, Kouraklis, Dimitrios Karousos (Laiko University Hospital), Stylianos, Germanos, Constantinos Marinos (Larissa General Hospital), Christos, Anthoulakis, Nikolaos, Nikoloudis, Guatemala: Gustavo Recinos, Nikolaos Mitroudis (Serres General Hospital)., Sergio, Estupinian, Walter Forno (Hospital De Accidentes Ceibal), José René Arévalo Azmitia (Hospital General De Enfermedades, Cirugia De Emergencia, Instituto Guatemalteco De Seguridad Social), Carla Cecilia Ramã­rez Cabrera (Hospital General De Enfermedades, Servicio De Cirugia Abdominal, Romeo, Guevara, Maria, Aguilera, Napoleon, Mendez, Cesar Augusto Azmitia Mendizabal, Pablo, Ramazzini, Mario Contreras Urquizu (Hospital General San Juan De Dios), Fernando, Tale, Rafael, Soley, Emanuel, Barrios, Emmanuel Barrios (Hospital Juan Jose Arevalo Bermejo), Daniel Estuardo Marroquín Rodríguez, Carlos Iván Pérez Velásquez, Sara María Contreras Mérida (Hospital Regional De Retalhuleu), Francisco, Regalado, Mario, Lopez, Miguel Siguantay (Hospital Roosevelt, Hong Kong: Fong Yee Lam, Guatemala)., Kylie Joan-yi Szeto, Charing Cheuk Ling Szeto, Wing Sum Li, Kieran Ka Kei Li, Man Fung Leung, Tony, Mak, India: SS Prasad, Simon Ng (Prince of Wales Hospital)., Anand, Kirishnan, Nidhi Gyanchandani (KMC Hospital), Bylapudi Seshu Kumar, Muthukumaran Rangarajan (Kovai Medical Centre &amp, Hospital), Sriram, Bhat, Anjana, Sreedharan, Kinnera (Kasturba Medical College), S. V., Yella, Reddy, Caranj, Venugopal, Sunil Kumar (Pes Institute Of Medical Sciences &amp, Research), Abhishek Mittal (Safdarjung Hospital, New, Delhi), Shravan, Nadkarni, Harish Neelamraju Lakshmi, Puneet Malik (Sawai Man Singh Medical College &amp, Hospitals, Jaipur, Rajasthan), Neel, Limaye, Srinivas, Pai, Pratik Jain (Sdm College Of Medical Sciences And Hospital), Monty, Khajanchi, Savni, Satoskar, Rajeev Satoskar (Seth Gordhandas Sunderdas Medical College And King Edward Memorial Hospital), Indonesia: Eldaa Prisca Refianti Sutanto, Abid Bin Mahamood (Travancore Medical College Hospital)., Daniel Ardian Soeselo, Chintya Tedjaatmadja (Atmajaya Hospital), Fitriana Nur Rahmawati, Radhian, Amandito, Maria Mayasari (Dr Cipto Mangunkusumo General Hospital, Iraq: Ruqaya Kadhim Mohammed Jawad Al-Hasani, Jakarta)., Hasan Ismael Ibraheem Al-Hameedi, Hasan Ismael Ibraheem, Israa Abdullah Aziz Al-Azraqi (Alsader Medical City), Lubna, Sabeeh, Rahma, Kamil, Marwan Shawki (Baghdad Medical City), Muwaffaq Mezeil Telfah (Department Of Surgery, College Of Medicine, University Of Mosul, Ireland: Amoudtha Rasendran, Al-Jumhoori Teaching Hospital)., Jacqueline, Sheehan, Robert, Kerley, Caoimhe, Normile, Richard William Gilbert, Jiheon, Song, Mohamed, Dablouk, Linnea, Mauro, Mohammed Osman Dablouk, Michael, Hanrahan, Paul, Kielty, Eleanor Marks (Cork University Hospital), Simon, Gosling, Michelle, Mccarthy, Amoudtha Rasendran (Cork University Hospital &amp, University College Cork), Diya, Mirghani, Syed Altaf Naqvi, Chee Siong Wong (Limerick University Hospital), Siyi, Chung, Reuban, D'Cruz, Ronan Cahill (Mater Misericordiae University Hospital), Simon George Gosling, Amoudtha, Rasendran, Ciara, Fahy, Diana Duarte Cadogan, Anna, Powell, Richard, Gilbert, Caroline, Clifford, Aoife Driscoll (Mercy University Hospital), Stassen, Paul, Chris, Lee, Ross Bowe (Midlands Regional Hospital Mullingar), William, Hutch, Michael Hanrahan (University College Cork), Helen, Mohan, Maeve, O'Neill, Italy: Piergiorgio Danelli, Kenneth Mealy (Wexford General Hospital)., Andrea, Bondurri, Anna Maffioli (Azienda Ospedaliera Luigi Sacco, - Polo Universitario), Mario, Pasini, Giacomo, Pata, Stefano Roncali (Azienda Ospedaliera Spedali Civili Di Brescia, - Chirurgia Generale), Paolo, Silvani, Michele, Carlucci, Roberto Faccincani (Irccs Ospedale San Raffaele), Luigi, Bonavina, Yuri, Macchitella, Chiara Ceriani (University of Milan, IRCCS Policlinico San Donato), Gregorio, Tugnoli, Salomone Di Saverio, Khaled Khattab (Maggiore Hospital), Miguel Angel Paludi, Domenica, Pata, Luigi Maria Cloro (Nicola Giannettasio Hospital), Andrea, Allegri, Federico Coccolini (Papa Giovanni Xxiii Hospital), Ezio, Veronese, Luca, Bortolasi, Alireza Hasheminia (San Bonifacio Hospital), Giacomo, Nastri, Massimiliano Dal Canto, Stefano Cucumazzo (Santa Croce Hospital), Angelo, Benevento, Gaetano Tessera (Sant'Antonio Abate Hospital, Gallarate), Pier Paolo Grandinetti, Alessio, Maniscalco, Giovanni Luca Lamanna (Santi Benvenuto, E Rocco Hospital Asur), Luca, Turati, Giovanni, Sgroi, Emanuele Rausa (Treviglio Hospital), Roberta, Villa, Michela, Monteleone, David Merlini (Unita' Di Chirurgia D'urgenza Azienda Ospedaliera Salvini), Federico, Coccolini, Andrea Allegri (Unit Of General Surgery, I, Papa Giovanni Xxiii Hospital), Veronica, Grassi, Roberto, Cirocchi, Libya: Hamza Waleed, Alban Cacurri (University Of Perugia)., Ahmed, Diab, Lithuania: Mantas Jokubauskas, Fathi Elzowawi (Misurata Central Hospital)., Karolis, Varkalys, Donatas Venskutonis (Kaunas Clinical Hospital), Robertas, Pranevicius, Viktorija Ambrozeviciute (Klaipedas Seaman Hospital), Simona, Juciute, Austė Skardžiukaitė (Lietuvos Sveikatos Mokslų Universitetas), Saulius, Bradulskis, Linas, Urbanavicius, Aiste, Austraite, Romualdas, Riauka, Zilvinas Dambrauskas (Lithuanian University Of Health Sciences), Paulius, Karumnas, Zigmantas, Urniezius, Reda Zilinskiene (Republic Hospital Of Kaunas), Anele Rudzenskaite (Republic Hospital Of Panevezys), Ausrine, Usaityte, Margarita, Montrimaite, Nerijus Kaselis (Republic Klaipeda Hospital), Andrius, Strazdas, Kristijonas Jokubonis (Stasys Kudirka Regional Hospital Of Alytus), Kornelija, Maceviciute, Virgilijus, Beisa, Kestutis, Strupas, Erikas Laugzemys (Vilnius University, Center Of Abdominal Surgery), Andrej, Kolosov, Valdemaras, Jotautas, Ignas Rakita (Vilnius University Hospital Santariskiu Clinics), Saulius, Mikalauskas, Darius, Kazanavicius, Rokas, Rackauskas, Virgilijus Beisa (Vilnius University Hospital Santariskiu Klinikos), Ritauras, Rakauskas, Malawi: Ross Coomber, Egle Preckailaite (Vsi Jonavos Ligonine)., Kenneth, Johnson, Malaysia: Dineshwary Periasammy, Jennifer Nowers (Queen Elizabeth Hospital)., Afizah, Salleh, Andre Das (Hospital Kajang), Reuben Goh Ern Tze, Milaksh Nirumal Kumar, Nik Azim Nik Abdullah (Sarawak General Hospital), Nik Ritza Kosai, Mustafa, Taher, Reynu Rajan (Universiti Kebangsaan Malaysia Medical Centre), Hoong Yin Chong, Malta: Marija Agius, Cheng Chun Goh (University Malaya Medical Centre)., Maureen, Bezzina, Roberta, Bugeja, Martinique, Vella-Baldacchino, Andrew, Spina, Josephine Psaila (Mater Dei Hospital, Martinique: Helene Francois-Coridon, Malta)., Cecilia, Tolg, Jean-Francois Colombani (Department Of Pediatric Surgery, Mother And Children's Hospital, Mexico: Carmina Diaz-Zorrilla, University Hospital Of Martinique)., Antonio Ramos-De La Medina, Mozambique: Mário Jacobe, Samantha Corro-Diaz Gonzalez (Hospital Español de Veracruz)., Domingos, Mapasse, New Zealand: Ramadan Oumer, Elizabeth Snyder (Hospital Central Maputo)., Mohammed Osman (Whangarei Hospital, Nigeria: Aminu Mohammad, Northland District Health Board)., Lofty-John, Anyanwu, Abdulrahman Sheshe (Aminu Kano Teaching Hospital), Alaba, Adesina, Olubukola, Faturoti, Ogechukwu Taiwo (Babcock University Teaching Hospital), Muhammad Habib Ibrahim, Abdulrasheed, A Nasir, Siyaka Itopa Suleiman (Federal Medical Centre, Birnin, Kebbi), Adewale, Adeniyi, Opeoluwa, Adesanya, Ademola Adebanjo (Federal Medical Centre), Roland, Osuoji, Kazeem, Atobatele, Ayokunle, Ogunyemi, Omolara, Williams, Mobolaji, Oludara, Olabode Oshodi (Lagos State University Teaching Hospital), Adesoji, Ademuyiwa, AbdulRazzaq Oluwagbemiga Lawal, Felix, Alakaloko, Olumide, Elebute, Adedapo, Osinowo, Christopher Bode(Lagos University Teaching Hospital), Abidemi Adesuyi (National Hospital Abuja), Adesoji, Tade, Adeleke, Adekoya, Collins Nwokoro (Olabisi Onabanjo University Teaching Hospital), Omobolaji, O Ayandipo, Taiwo Akeem Lawal, Akinlabi, E Ajao (University College Hospital), Samuel Sani Ali, Babatunde, Odeyemi, Samson Olori (University of Abuja Teaching Hospital), Ademola, Popoola, Ademola, Adeyeye, Lossius (Department Of Gastrointestinal Surgery, James Adeniran (University of Ilorin Teaching Hospital). Norway: William J., Olavs Hospital, St., Trondheim University Hospital), Ingemar Havemann (Soerlandet Hospital Kristiansand), Kenneth, Thorsen, Jon Kristian Narvestad, Kjetil Soreide (Stavanger University Hospital), Trude Beate Wold, Linn Nymo (University Hospital Of North Norway, Oman: Mohammed Elsiddig, Troms)., Pakistan: Kamran Faisal Bhopal, Manzoor Dar (Sohar Hospital)., Zainab, Iftikhar, Muhammad Mohsin Furqan (Bahawal Victoria Hospital), Bakhtiar, Nighat, Masood, Jawaid, Abdul Khalique (Dow University Hospital), Ahsan, Zil-E-Ali, Anam Rashid (Fatima Memorial Hospital), Hasnain Abbas Dharamshi, Tahira, Naqvi, Ahmad Faraz (Karachi Medical And Dental College, Abbasi Shaheed Hospital), Abdul Wahid Anwar, Tahir Muhammad Yaseen, Ghina Shamim Shamsi, Ghina, Shamsi, Tahir, Yaseen, Paraguay: Horacio Paredes Decoud, Wahid Anwer (The Indus Hospital)., Omar, Aguilera, Ismael Isaac Zelada Alvarez, Juan Marcelo Delgado, Gustavo Miguel Machain Vega, Peru: Wendy Leslie Messa Aguilar, Helmut Alfredo Segovia Lohse (Hospital De Clínicas)., Jose Antonio Cabala Chiong, Essalud), Ana Cecilia Manchego Bautista (Carlos Alberto Seguin Escobedo National Hospital., Eduardo, Huaman, Sergio, Zegarra, Rony Camacho (Hospital Necional Guillermo Almenara), Jose María Vergara Celis, Diego Alonso Romani Pozo (Hospital De Emergencias Pediatricas), José, Hamasaki, Edilberto, Temoche, Jaime Herrera-Matta (Hospital De Policia), Carla Pierina García Torres, Luis Miguel Alvarez Barreda, Ronald Renato Barrionuevo Ojeda (Hospital Goyeneche), Octavio Garaycochea (Hospital Ii -1 Minsa Moyobamba), Melanie Castro Mollo, Mitchelle Solange De Fã Tima Linares Delgado, Francisco Fujii (Hospital Maria Auxiliadora), Ana Cecilia Manchego Bautista, Wendy Leslie Messa Aguilar, Jose Antonio Cabala Chiong (Hospital Nacional Carlos Alberto Seguin), Susana Yrma Aranzabal Durand, Carlos Alejandro Arroyo Basto, Nelson Manuel Urbina Rojas (Hospital Nacional Edgardo Rebagliati Martins-Essalud), Sebastian Bernardo Shu Yip, Ana Lucia Contreras Vergara, Andrea Echevarria Rosas Moran, Giuliano Borda Luque, Manuel Rodriguez Castro, Ramon Alvarado Jaramillo (Hospital Nacional Cayetano Heredia), George Manrique Sila, Crislee Elizabeth Lopez, Mardelangel Zapata Ponze De Leon, Massiell, Machaca, Ronald Coasaca Huaraya, Andy, Arenas, Crislee, López, Clara Milagros Herrera Puma, Wilfredo, Pino, Christian, Hinojosa, Melanie Zapata Ponze De Leon, Susan, Limache, George Manrrique Sila, Portugal: Renato Melo, Layza-Alejandra Mercado Rodriguez (Hospital Regional Honorio Delgado Espinoza)., Jose, Costa-Maia, Romania: Ionasc Dan, Nuno Muralha (Servico De Cirurgia Geral - Centro Hospitalar Sao Joao - Porto). Reunion: Frederique Sauvat (Chu Reunion)., Mircea, Hogea, Pandi Eduard (Emergency Clinical Hospital Brasov), Razvan-Matei, Bratu, Mircea, Beuran, Ionut-Bogdan, Diaconescu, Bogdan-Valeriu, Martian, Florin-Mihail, Iordache, Mihaela Vartic (Emergency Clinical Hospital Bucharest), Lucian Corneliu Vida, Liviu Iuliu Muntean, Rwanda: Vizir Jean Paul Nsengimana (Chuk), Aurel Sandu Mironescu (Spitalul Clinic De Copii Brasov)., Alice, Niragire, Jean De La Croix Allen Ingabire, San Marino: Nicola Zanini, Eugene Niyirera (University Teaching Hospital Of Kigali)., Elio, Jovine, Alomar, Giovanni Landolfo (San Marino State Hospital). Saudi Arabia: Ibrahim N., Alnuqaydan, Saleh A., Altwigry (Buraydah Central Hospital), Abdulrahman M., Moayad, Othman, Nohad Osman (Imam Abdulrahman Al Faisal Hospital), Enas Alqahtani (King Abdulaziz Hospital Al Ahsa National Guard), Mohammed, Alzahrani, Rifan, Alyami, Emad Aljohani (King Abdulaziz Medical City), Ibrahim, Alhabli, Zaher, Mikwar, Sultan Almuallem (King Abdulaziz Medical City (King Khalid National Guard Hospital, Jeddah), Emad, Aljohani, Mohammed Alzahrani (King Abdulaziz Medical City, Riyadh), Abrar, Nawawi, Mohamad, Bakhaidar, Maghrabi, Ashraf A., Mohammed, Alsaggaf, Murad, Aljiffry, Abdulmalik, Altaf, Ahmad, Khoja, Alaa, Habeebullah, Nouf Akeel (Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi, Arabia), Nashat, Ghandora, Abdullah, Almoflihi, Abdulmalik Huwait (King Fahad General Hospital), Abeer, Al-shammari, Mashael Al-Mousa (King Fahad Hospital), Masood, Alghamdi, Walid, Adham, Bandar, Albeladi, Muayad Ahmed Alfarsi, Atif, Mahdi, Saad Al Awwad (King Fahd Hospital), Thamer, Nouh, Mazen Hassanain (King Khaled University Hospital, King Saud University), Salman, Aldhafeeri, Nawal, Sadig, Osama Algohary (King Khalid General Hospital), Mohannad, Aledrisy, Ahmad Alrifaie (King Khalid National Guard Hospital), Mohammed, Alrowais, Amani Althwainy (Department of Surgery, Alaa, Shabkah, Uthman, Alamoudi, Mawaddah Alrajraji (National Guard Hospital), Basim, Alghamdi, Saud, Aljohani, Abdullah Daqeeq (Rcymc), South Africa: Vicky Jennings, Jubran J Al-Faifi (Security Forces Hospital)., Nyawira, Ngayu, Rachel Moore (Chris Hani Baragwanath Academic Hospital), Victor Kong (Edendale Hospital), Hayden, Kretzmann, Katie, Connor, Daniel Nel (Frere Hospital), Colleen, Sampson, Eugenio Panieri (Groote Schuur), Nosisa Sishuba (Helen Joseph Hospital, Department Of Surgery, University Of The Witwatersrand), Myint, Tun, Albert Mohale Mphatsoe, Jo-Anne Carreira (Leratong Hospital), Mark Wagener (Ngwelezana Hospital), Stefan, Botes, Spain: Fernando Fernandez-Bueno (Hospital Central De La Defensa Gomez Ulla), Danelo Du Plessis (Rob Ferreira Hospital)., Jose, Aguilar-Jimenez, Sms), Jose Andres Garcia-Marin (Hospital Morales Meseguer., Lorena Solar García, Luis Joaquín García Florez, Rubén Darío Arias Pacheco (Hospital San Agustín), Janet, Pagnozzi, Jimy Harold Jara Quezada, Jose Luis Rodicio, German, Minguez, Raquel, Rodríguez-Uría, Paul, Ugalde, Camilo, Lopez-Arevalo, Luis, Barneo, Jessica Patricia Gonzales Stuva (Hospital Universitario Central De Asturias), Irene, Ortega-Vazquez, Lorena, Rodriguez, Sri Lanka: Prasad Pitigala Arachchi, Norberto Herrera (Severo Ochoa University Hospital)., Wanigasekara Senanayake Mudiyanselage Kithsiri Janakantha Senanayake, Lalith Asanka Jayasooriya Jayasooriya Arachchige (Department Of General Surgery, Teaching Hospital Kandy), Sivasuriya, Sivaganesh, Dulan Irusha Samaraweera, Sudan: Ahmed Elgaili Khalid Musa, Vimalakanthan Thanusan (National Hospital Of Sri Lanka)., Reem Mohammed Hassan Balila, Mohamed Awad Elkarim Hamad Mohamed (Ibrahim Malik Teaching Hospital), Hussein, Ali, Hagir Zain Elabdin, Alaa Hassan (Jarash International Specialized Hospital), Sefeldin, Mahdi, Hala, Ahmed, Sahar Abdoun Ishag Idris (Khartoum Teaching Hospital), Makki, Elsayed, Mohammed, Elsayed, Sweden: Magnus Boijsen, Mohamed Mahmoud (Omdurman Teaching Hospital)., Per-Olof Lundgren (Capio St Goran Hospital), Ulf, Gustafsson, Ali Kiasat (Danderyds Hospital), Fredrik, Wogensen, Emma, Jurdell, Anders Thorell (Department Of Surgery, Ersta, Hospital, Stockholm), Hildur, Thorarinsdottir, Maria Utter (Helsingborgs Lasarett), Sami Martin Sundstrom (Hudiksvall Sjukhus), Cecilia, Wredberg, Ann Kjellin (Karolinska Universitetssjukhuset), Johanna, Nyberg, Bjorn Frisk (Skaraborg Hospital Skovde), Malin, Sund, Linda, Andersson, Ulf Gunnarsson (Department Of Surgical And Perioperative Sciences, Umea University and Umea University Hospital), Yücel, Cengiz, Sandra, Ahlqvist, Ida Björklund (Sundsvall Hostpital) Hanna Royson, Per Weber (Vaexjoe Central Hospital), Hans-Ivar, Pahlsson, Eva Borin (Visby Hospital, Department Of Surgery), Maria Hjertberg (Vrinnevi Hospital), Hanna, Royson, Switzerland: Roger Schmid, Per Weber (Vaxjo Central Hospital)., Debora, Schivo, Vasileios Despotidis (Bürgerspital Solothurn), Stefan, Breitenstein, Ralph, F Staerkle, Erik Schadde (Kantonsspital Winterthur), Fabian, Deichsel, Alexandra, Gerosa, Antonio Nocito (Kantonsspital Baden), Dimitri Aristotle Raptis, Barbara, Mijuskovic, Markus, Zuber, Lukas Eisner (Kantonsspital Olten), Swantje, Kruspi, Katharina Beate Reinisch, Christin Schoewe (Kreisspital Fuer Das Freiamt Muri Ag), Allan, Novak, Palma, Adrian F., Gerfried Teufelberger (Kreisspital Muri, Tanzania: Msafiri Kimaro, Department Of Surgery)., Rachel King (Mbalizi Christian Designated Hospital) Turkey: Ali Zeynel Abidin Balkan, Mehmet, Gumar, Mehmet Ali Yavuz (Harran University Research And Treatment Hospital), Ufuk, Karabacak, Gokhan, Lap, Bahar Busra Ozkan (Ondokuz Mayis University, Medical, Faculty), Bahar Busra Ozkan, United Kingdom: Ryan Adams, Murat Karakahya (Ordu University Training And Research Hospital)., Robert, Morton, Liam, Henderson, Ruth, Gratton, Keiran David Clement, Kate Yu-Ching Chang, David, Mcnish, Ryan, Mcintosh, William Milligan (Aberdeen Royal Infirmary), Brendan, Skelly, Hannah, Anderson-Knight, Roger Lawther (Altnagelvin Area Hospital), Jemina, Onimowo, Veereanna, Shatkar, Shivanee Tharmalingam (Barking, Havering And Redbridge University Hospitals Trust (Queens Hospital, Romford), Evelina, Woin, Tessa, Fautz, Oliver Ziff (Barnet General Hospital), Shiva, Dindyal, Sam, Arman, Shagorika, Talukder, Vijay, Gadhvi, Shagorika Talukder (Basildon And Thurrock University Foundation Trust), Luen Shaun Chew, Jonathan Heath (Blackpool Victoria Teaching Hospitals), Natalie, Blencowe, Sally, Hallam, Katherine Gash (Bristol Royal Infirmary), Gurdeep Singh Mannu, Dimitris-Christos, Zachariades, Ailsa Claire Snaith (Buckinghamshire NHS Trust), Thusitha Sampath Hettiarachchi, Arjun, Nesaratnam, James Wheeler (Cambridge University Hospitals NHS Foundation Trust), Darragh, Mccullagh, Joshua Michael Clements, Ata Khan (Causeway Hospital), Foteini, Koumpa, Christina, Neophytou, Jessica, Roth, Wai Cheong Soon, Mohammed, Deputy, Ahmed, Ahmed, Annelisse, Ashton, Joe, Vincent, Jack, Almy, Taufiq, Khan, John Lee, Y Allen, Charlotte Jane Mcintyre, Dominic Charles Marshall (Charing Cross Hospital, Imperial College Healthcare NHS Trust), Mark, Sykes, Nebil, Behar, Harriet Jordan (Chelsea And Westminster Hospital), Yaseen, Rajjoub, Thomas Sherman (Cheltenham General Hospital), Timothy, White, Anna, Watts, Rohan Ardley (Chesterfield Royal Hospital NHS Foundation Trust), Tan, Arulampalam, Apar, Shah, Damien Brown (Colchester Hospital University NHS Foundation Trust), Emma, Blower, Paul, Sutton, Konstantinos, Gasteratos, Dale Vimalachandran (Countess Of Chester Hospital), Cathy, Magee, Andrew Mcguigan (Craigavon Area Hospital), Stephen, Mcaleer, Clare Morgan (Daisy Hill Hospital), Sarah Braungart (Department Of Paediatric Surgery, Leeds General Infirmary), Kirsten, Lafferty, Peter, Labib, Andrei, Tanase, Clodagh, Mangan, Lillian, Reza, Clodagh Mangan (Derriford Hospital), Helen, Woodward, Craig, Gouldthorpe, Megan Turner (Diana Princess Of Wales Hospital), Jonathan R, L Wild, Tom AM Malik, Victoria, K Proctor (Doncaster Royal Infirmary NHS Foundation Trust), Kalon, Hewage, James Davies (Dorset County Hospital), Andre, Dubois, Sayed, Sarwary, Ali, Zardab, Alan, Grant, Robert Mcintyre (Dr Grays Hospital), Yogendra Praveen Mogan, Weiguang, Ho, Bryon Frankie Hon Khi Chong (Dumfries And Galloway Royal Infirmary), Shirish, Tewari, Gemma, Humm, Eriberto Farinella (East And North Hertfordshire NHS Trust Lister Hospital) Nigel, J Hall, Naomi, J Wright, Christina, P Major (Evelina Children's Hospital), Thelma, Xerri, Phoebe De Bono, Jasim, Amin, Mustafa, Farhad, Camilleri-Brennan, John F., Andrew G, N Robertson, Joanna, Swann, James, Richards, Aijaz, Jabbar, Myranda, Attard, Hannah, Burns, Euan, Macdonald, Matthew, Baldacchino, Jennifer, Skehan, Julian Camilleri-Brennan (Forth Valley Royal Hospital), Tom Falconer Hall, Madelaine, Gimzewska, Greta Mclachlan (Frimley Park Hospital), Jamie, Shah, James Giles (George Elliot Hospital), Selina, Chiu, Beatrix, Weber, Selina Man Yeng Chiu, Saskia Highcock (Gilbert Bain Hospital), Maleeha, Hassan, William, Beasley, Apostolos, Vlachogiorgos, Stephen, Dias, Geta, Maharaj, Rosie Mcdonald (Glangwili General Hospital), Alisdair, Macdonald, Paul, Witherspoon, Alan Baird (Glasgow Southern General Hospital), Panchali, Sarmah, Nikki, Green, Haney Youssef (Good Hope Hospital), Kate, Cross, Clare, M Rees, Bernard Van Duren (Great Ormond Street Hospital For Children NHS Foundation Trust), Emma Upchurch (Great Western Hospital), Khurram, Khan, Haytham, Abudeeb, Ahmed Hammad (Hairmyres Hospital, Nhs, Lanarkshire), Sharad, Karandikar, Doug, Bowley, Ahmed Karim (Heart Of England Foundation Trust), Witold, Chachulski, Liam, Richardson, Giles, Dawnay, Ben, Thompson, Ajayesh, Mistry, Aneel, Bhangu, Millika, Ghetia, Sudipta, Roy, Ossama, Al-Obaedi, Kaustuv Das (Hereford County Hospital), Ash, Prabhudesai, Cocker, Dm, Jessica Juliana Tan (Hillingdon Hospital), Robert, Tyler, Filippo Di Franco, Shruti Ayyar (Hinchingbrooke Hospital), Sayinthen, Vivekanantham, Shyam Gokani (Imperial College London), Michael, Gillespie, Katrin Gudlaugsdottir (Inverclyde Royal Hospital), Theodore, Pezas, Chelise, Currow, Matthew Young-Han Kim (Ipswich Hospital NHS Trust), Amerdip, Birring, Joanne, Edwards, Ased, Ali, Suparna, Das, Madan, Jha, Kieran Atkinson (James Cook University Hospital), Joshua, Luck, Thomas, Fozard, Michael Puttick (John Radcliffe Hospital), Yahya, Salama, Rohi, Shah, Ahmad Aboelkassem Ibrahem, Hamdi, Ebdewi, Gianpiero, Gravante, Saleem El-Rabaa (Kettering General Hospital), Henry, Nnajiuba, Rebecca, Allott, Aman Bhargava (King George Hospital), Zoe, Chan, Zaffar Hassan (Kings College Hospital), Misty, Makinde, David, Hemingway, Ramzana, Dean, Alexander, Boddy, Ahmed, Aber, Vijay Patel (Leicester Royal Infirmary), Jehangirshaw Parakh (Leighton Hospital, - Mid Cheshire NHS Foundation Trust), Sunil Parthiban (Lister Hospital), Harmony Kaur Ubhi, Simon-Peter Hosein (Luton And Dunstable Hospital), Simon, Ward, Kamran Malik (Macclesfield District General Hospital), Leifa, Jennings, Tom, Newton, Mirna, Alkhouri, Min Kyu Kang, Christopher, Houlden, Jonathan Barry (Morriston Hospital), Imtanan, Raza, Alistair, Farquharson, Sanjeet Bhattacharya (NHS Ayrshire), William, Milligan, Kate, Chang, Liam Henderson (NHS Grampian), Michael S, J Wilson, Yan Ning Neo, Ibrahim, Ibrahim, Emily, Chan, Fraser, S Peck, Pei, J Lim, Alexander, S North, Rebecca, Blundell, Adam Williamson (Ninewells Hospital, NHS), Dina, Fouad, Ashish Minocha (Norfolk And Norwich University Hospital), Kathryn, Mccarthy, Emma, Court, Alice Chambers (North Bristol NHS Trust), Jenna, Yee, Ji Chung Tham, Ceri Beaton (North Devon District Hospital), Una, Walsh, Joseph, Lockey, Salman, Bokhari, Lara, Howells, Megan, Griffiths, Laura Yallop (Northwick Park Hospital), Shailinder, Singh, Omar, Nasher, Paul Jackson (Nottingham Children's Hospital At Queens Medical Centre Campus), Michael, Puttick, Thomas Fozard (Oxford University Hospitals), Abdul Muiz Shariffuddin, Weng Chee Ho, Michael Sj Wilson, Gurpreet Pabla (Perth Royal Infirmary), Saed, Ramzi, Shady, Zeidan, Jennifer Doughty (Plymouth Hospitals NHS Trust), Sidhartha, Sinha, Ross, Davenport, Jason Lewis (Princess Alexandra Hospital), Leo, Duffy, Elizabeth, Mcaleer, Eleanor Williams (Princess Of Wales Hospital), Robin, Som, Omar Javed (Queen Elizabeth Hospital Woolwich), Matthew, Boal, Nicola, Harrison, Habib, Tafazal, Omar, Javed, Tom, Brogden, Ewen Griffiths (Queen Elizabeth Hospital Birmingham) Rhalumi Daniel Obute, Thomas, E Glover, David, J Clark (Queen Elizabeth Hospital King's Lynn), Mohamed, Boshnaq, Mansoor, Akhtar, Pascale, Capleton, Samer, Doughan, Mohamed, Rabie, Ismail Mohamed (Queen Elizabeth The Queen Mother Hospital), Duncan, Samuel, Lauren, Dickson, Matthew, Kennedy, Eleanor, Dempster, Emma, Brown, Natalie, Maple, Eimear, Monaghan, Bernhard, Wolf, Alicia Garland (Raigmore Hospital), Arthur, Mcphee, David, Anderson, Robert Anderson (Royal Alexandria Hospital), Sarah, Hassan, Dave Smith (Royal Bolton Hospital), Jonathan, Lund, Catherine, Boereboom, Jennifer, Murphy, Gillian, Tierney, Samson Tou (Royal Derby Hospital), Eleanor Franziska Zimmermann, Neil James Smart, Andrea Marie Warwick (Royal Devon And Exeter National Health Service Foundation Trust), Theodora, Stasinou, Ian, Daniels, Kim Findlay-Cooper (Royal Devon &amp, Exeter NHS Foundation Trust), Stefan, Mitrasinovic, Swayamjyoti, Ray, Massimo, Varcada, Rovan, D'Souza, Sharif Omara (Royal Free Hospital), Matthew, Spurr, Lucienne, Parkinson, Anthony Hanks (Royal Glamorgan Hospital), Jennifer, Ma, Emily, Abington, Meera, Ramcharn, Gethin Williams (Royal Gwent Hospital), Joseph, Winstanley, Kennedy, Ewan D., Emily NW Yeung (Royal Hospital For Sick Children), Catrin, Jones, Stephen, O'Neill, Shujing Jane Lim, Ignatius, Liew, Hari, Nair, Cameron, Fairfield, Julia, Oh, Samantha, Koh, Andrew, Wilson, Catherine Fairfield (Royal Infirmary Of Edinburgh), Delran, Anandkumar, Ashok, Kirupagaran, Timothy, F Jones, Hew Dt Torrance, Alexander, J Fowler, Charmilie, Chandrakumar, Priyank, Patel, Syed Faaz Ashraf, Lakhani, Sonam M., Aaron Lawson Mclean, Sonia Basson (Royal London Hospital), Jeremy, Batt, Catriona, Bowman, Natasha Benons (Royal United Hospital Bath), Clare, Mason, Rebecca, Harrison, John Quayle (Salford Royal NHS Foundation Trust), Tom, Barker, Virginia, Summerour, Edward Harper (Sandwell And West Birmingham Hospitals NHS Trust), Caroline, Smith, Matthew Hampton (Sheffield Children's Hospital), Sophie, K Pitt, Alex, E Ward, Timothy, O’Connor, Emily, G Heywood, Thomas, M Drake (Sheffield Teaching Hospitals NHS Foundation Trust), Abeed, Chowdhury, Sina, Hossaini, Nicholas Fs Watson (Sherwood Forest Hospitals NHS Foundation Trust), Doug, Mckechnie, Ayaan, Farah, Anita Chun (Southend University Hospital), Hoey, Koh, Grace, Lim, Graham Sunderland (Southern General Hospital), Laura, Gould, Alice Chambers (Southmead Hospital), C Munipalle, P, Rooney, H, D R, L Browning (Southmead Hospital, North Bristol NHS Trust), Bernadette, Pereira, Kristof Nemeth (St Georges Healthcare NHS Trust), Emily, Decker, Stefano, Giuliani, George's Healthcare NHS Trust And University), Aly Shalaby (St., Shafaque, Shaikh, Chern Yan Tan, James's University Hospital), Ebrahim Y A Palkhi (St., Aleksandra, Szczap, Swathikan, Chidambaram, Chee Yang Chen, Kavian, Kulasabanathan, Srishti Chhabra (St Mary's Hospital), Elisabeth, Kostov, Philippe, Harbord, Mary's Hospital), James Barnacle (St., Madan Mohan Palliyil, Mina, Zikry, Johnathan, Porter, Charef, Raslan, Shazia, Hafiz, Niksa, Soltani, Katie Baillie (Stockport NHS Foundation Trust), Priyanka, Singh, Shailee, Sheth, Kishen, Patel, Mahry, Khalili, Jeesoo, Choi, Matthew Benger (St Thomas' Hospital), Lucy, Marples, Alastair, Macfarlane, Thomas Hospital), Ramesh Thurairaja (St., Tamsin, Boyce, Harriet, Whewell, Elin Jones (The Royal Gwent Hospital), Francesca, Th'Ng, Nichola Robertson (The Royal Infirmary Of Edinburgh), Ahmad, Mirza, Haroon, Saeed, Simon Galloway (The University Hospital Of South Manchester), Gia, Elena, Mohammad, Afzal, Mohamed Zakir (United Lincolnshire Hospitals, - Pilgrim Hospital), Peter, Sodde, Charles, Hand, Aiesha, Sriram, Tamsyn, Clark, Patrick, Holton, Amy Livesey (University Hospital Coventry And Warwickshire), Yashashwi, Sinha, Fahad Mujtaba Iqbal, Indervir Singh Bharj (University Hospital Of North Midlands), Adriana, Rotundo, Cara, Jenvey, Robert Slade (University Hospital Of North Staffordshire NHS Trust), David, Golding, Samuel, Haines, Ali Adel Ne'ma Abdullah, Thomas, W Tilston, Dafydd, Loughran, Danielle, Donoghue, Lorenzo, Giacci, Mohamed Ashur Sherif, Peter, Harrison, Alethea Tang (University Hospital Of Wales), Deevia Kotecha (University Hospitals Leicester, - Leicester Royal Infirmary), Mohamed, Elshaer, Tomas, Urbonas, Amjid, Riaz, Annie, Chapman, Parisha, Acharya, Joseph Shalhoub (Watford General Hospital), Cathleen, Grossart, David McMorran (Western General Hospital), Makhosini, Mlotshwa, William, Hawkins, Sofronis Loizides (Western Sussex Hospitals NHS Trust), Kandaswamy, Krishna, Melanie, Orchard, Chik Wai Ho (Weston General Hospital), Peter, Thomson, Shahab, Khan, Fiona, Taylor, Jalak, Shukla, Emma Elizabeth Howie (Whipps Cross University Hospital), Linda, Macdonald, Olusegun, Komolafe, Neil Mcintyre (Wishaw General Hospital), James, Cragg, Jody, Parker, Duncan Stewart (Wrexham Maelor Hospital), Luke, Lintin, Julia, Tracy, United States: George Molina, Tahir Farooq (Yeovil District Hospital)., Haytham, Kaafarani, Laura Luque (Massachusetts General Hospital), Robel, Beyene, Jack, Sava, Mark Scott (Medstar Washington Hospital Center), Mamta, Swaroop, Raelene Kennedy (Northwestern Memorial Hospital), Ijeoma, A Azodo, Daithi, Heffernan, Tristen, Chun, Andrew Stephen (The Rhode Island Hospital), Melanie, Sion, Weinstein, Michael S., Viren Punja (Thomas Jefferson University Hospital), Nikolay, Bugaev, Monica, Goodstein, Shadi Razmdjou (Tufts Medical Center), Eric, Etchill, Juan Carlos Puyana, Matthew Kesinger (University of Pittsburgh Medical Center, - Presbyterian Hospital), Lena, Napolitano, Kathleen, To, Zambia: Oliver Todd, Mark Hemmila (University Of Michigan)., Edward, Jenner, Local collaborators (GlobalSurg-2) Albania: Besmir Grizhja, Ellen Hoogakker (St Francis Hospital)., Shpetim, Ymeri, Gezim Galiqi (Spitali Rajonal Shkoder), Argentina: Roberto Klappenbach, Diego, Antezana, Alvaro Enrique Mendoza Beleño, Cecilia, Costa, Belen, Sanchez, Susan Aviles (Hospital Zonal General De Agudos Simplemente Evita), Claudio Gabriel Fermani, Rubén, Balmaceda, Santiago, Villalobos, Lagomaggiore, Juan Manuel Carmona (Hospital Luis C., Mendoza), Australia: Daniel Hamill, Peter, Deutschmann, Simone, Sandler, Daniel Cox (Alice Springs Hospital), Ram, Nataraja, Claire, Sharpin, Damir Ljuhar (Monash Medical Center), Demi Gray, Morgan Haines (Port Macquarie Base Hospital), Dush, Iyer, Nithya, Niranjan, Scott D'Amours (Liverpool Hospital), Morvarid, Ashtari, Bangladesh: Ashrarur Rahman Mitul, Helena Franco (Gold Coast University Hospital)., Sabbir Karim (Dhaka Shishu (Children) Hospital), Nowrin F. Aman, Mahnuma Mahfuz Estee (Holy Family Red Crescent Medical College &amp, Umme, Salma, Joyeta, Razzaque, Tasnia Hamid Kanta (Dhaka Medical College And Hospital), Sayeeda Aktar Tori, Shadid, Alamin, Swapnil, Roy, Shadid Al Amin, Rezaul Karim (Armed Forces Medical College), Muhtarima, Haque, Amreen, Faruq, Farhana Iftekhar (Birdem Bangladesh Institute Of Research And Rehabilitation In Diabetes Endocrine And Metabolic Disorder General Hospital), Barbados: Margaret O'Shea, Greg, Padmore, Belarus: Andrey Litvin, Ramesh Jonnalagadda (Queen Elizabeth Hospital)., Aliaksandr, Filatau, Dzmitry, Paulouski, Maryna, Shubianok, Tatsiana Shachykava (Gomel Regional Clinical Hospital), Dzianis, Khokha, Vladimir Khokha (City Hospital) Benin: Fernande Djivoh, Francis Dossou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga), Djifid Morel Seto, Dansou Gaspard Gbessi, Bruno, Noukpozounkou, Yacoubou Imorou Souaibou (Centre National Hospitalier Et Universitaire Hubert Koutoukou Maga), Kpèmahouton René Keke, Fred Hodonou (Clinique Vignon), Ernest Yemalin Stephane Ahounou, Thierry Alihonou (Hopital El Fateh), Max, Dénakpo, Burundi: Carlos Nsengiyumva, Germain Ahlonsou (Hospital Saint Luc). Botswana: Alemayehu Ginbo Bedada (Princess Marina Hospital)., Sandrine, Kwizera, Cambodia: Philip Choi, Venerand Barendegere (Hopital Militaire De Kamenge)., Simon Stock (World Mate Emergency Hospital) Canada: Luai Jamal, China: Tzu-Ling Chen, Arnav Agarwal (The Hospital For Sick Children)., Colombia: Irene Montes, Chingwan Yip (Fudan University Affiliated Huashan Hospital)., Felipe, Zapata, Sebastian Sierra (Clinica CES), Maria Isabel Villegas Lanau, Ivan Mendoza Restrepo (Clinica Las Vegas), Ruben Santiago Restrepo Giraldo, Croatia: Edgar Domini, Maria Clara Mendoza Arango (Hospital Universitario San Vicente Fundación)., Robert, Karlo, Egypt: Mohamed Youssef, Jakov Mihanovic (Zadar General Hospital)., Waleed, Thabet, Aly, Sanad, Ahmed, Zaki, Noran, Abdel-Hameed, Mohamed, Mostafa, Muhammad Fathi Waleed Omar, Ahmed, Ghanem, Adel, Denewar, Eman, Emara, Eman, Rashad, Ahmad, Sakr, Rehab, Elashry, Sameh Emile (Mansoura University Hospital), Toqa, Khafagy, Sara, Elhamouly, Arwa, Elfarargy, Amna Mamdouh Mohamed, Ghada Saied Nagy, Abeer, Esam, Eman, Elwy, Aya, Hammad, Salwa, Khallaf, Eman, Ibrahim, Ahmed, Saidbadr, Ahmed, Moustafa, Amany Eldosouky Mohammed, Mohammed, Elgheriany, Eman, Abdelmageed, Eman Abd Al Raouf, Esraa Samir Elbanby, Maha, Elmasry, Mahitab Morsy Farahat, Eman Yahya Mansor, Eman Magdy Hegazy, Esraa, Gamal, Heba, Gamal, Hend, Kandil, Doaa Maher Abdelrouf, Mohamed Moaty (Menofiya University Hospital), Dina, Gamal, Nada, El-Sagheer, Mohamed, Salah, Salma, Magdy, Asmaa, Salah, Ahmed, Essam, Ahmed, Ali, Mahmoud, Badawy, Sara Ahmed (Beni Suef University Hospital), Mazed, Mohamed, Abdelrahman, Assal, Mohamed, Sleem, Mai, Ebidy, Aly Abd Elrazek, Diaaaldin, Zahran, Nourhan, Adam, Mohamed, Nazir, Adel, B Hassanein, Ahmed, Ismail, Amira, Elsawy, Rana, Mamdouh, Mohamed, Mabrouk, Lopna Ahmed Mohamed Ahmed, Mohamed Hassab Alnaby, Eman, Magdy, Manar, Abd-Elmawla, Marwan, Fahim, Bassant, Mowafy, Moustafa Ibrahim Mahmoud, Meran, Allam, Muhammad, Alkelani, Noran Halim El Gendy, Mariam Saad Aboul-Naga, Reham Alaa El-Din, Alyaa Halim Elgendy, Mohamed, Ismail, Mahmoud, Shalaby, Aya Adel Elsharkawy, Mahmoud Elsayed Moghazy, Khaled Hesham Elbisomy, Hend Adel Gawad Shakshouk, Mohamed Fouad Hamed, Mai Mohamed Ebidy, Mohamed Karkeet (Alexandria Main UniversIty Hospital), Hayam, Ahmed, Israa, Adel, Mohammad Elsayed Omar, Mohamed, Ibrahim, Omar, Ghoneim, Omar, Hesham, Shimaa, Gamal, Karim, Hilal, Omar, Arafa, Sawsan Adel Awad, Menatalla, Salem, Fawzia Abdellatif Elsherif, Nourhan, Elsabbagh, Aboelsoud, Moustafa R., Ahmed Hossam Eldin Fouad Rida, Amr, Hossameldin, Ethar, Hany, Yomna Hosny Asar, Nourhan, Anwar, Mohamed, Gadelkarim, Samar, Abdelhady, Eman Mohamed Morshedy, Reham, Saad, Nourhan, Soliman, Mahmoud Salama (Alexandria Medical Research Institute), Eslam, Ezzat, Arwa, Mohamed, Arwa, Ibrahim, Alaa, Fergany, Sara, Mohammed, Aya, Reda, Yomna, Allam, Hanan Adel Saad, Afnan, Abdelfatah, Aya Mohamed Fathy, Ahmed, El-Sehily, Esraa Abdalmageed Kasem, Ahmed Tarek Abdelbaset Hassan, Ahmed Rabeih Mohammed, Abdalla Gamal Saad, Arij, Ibrahim, Amr, Hassaan, Mohammed Mustafa Mohammed, Ghada, Elhoseny, Mohamed, Magdy, Esraa Abd Elkhalek, Yehia, Zakaria, Tarek, Ezzat, Ali Abo El Dahab, Mohamed, Kelany, Sara, Arafa, Osama Mokhtar Mohamed Hassan, Nermin Mohamed Badwi, Ahmad Saber Sleem, Hussien, Ahmed, Kholoud, Abdelbadeai, Mohamed Abozed Abdullah (Faculty Of Medicine, Zagazig, University), Muhammad Amsyar Auni Lokman, Suraya, Bahar, Anan Rady Abdelazeam, Abdelrahman, Adelshone, Muhammad Bin Hasnan, Athirah, Zulkifli, Siti Nur Alia Kamarulzamil, Abdelaziz, Elhendawy, Aliang, Latif, Ahmad Bin Adnan, Shahadatul, Shaharuddin, Aminah Hanum Haji Abdul Majid, Dina, Al-Marakby, Mohamad Jeffrey Bin Ismail, Elissa Rifhan Mohd Basir, Citra Dewi Mohd Ali, Aya Yehia Ata (Faculty Of Medicine, Tanta, University), Maha, Nasr, Asmaa, Rezq, Ahmed, Sheta, Sherif, Tariq, Abd Elkhalek Sallam, Abdelrhman KZ Darwish, Sohaila, Elmihy, Shady, Elhadry, Ahmed, Farag, Haidar, Hajeh, Abdelaziz, Abdelaal, Amro, Aglan, Ahmed, Zohair, Mahitab, Essam, Omar, Moussa, Esraa, El-Gizawy, Mostafa, Samy, Safia, Ali, Esraa, Elhalawany, Ahmed, Ata, Mohamed El Halawany, Mohamed, Nashat, Samar, Soliman, Alaa, Elazab, Mostada Samy (El-Menshawy General Hospital), Mohamed, A Abdelaziz, Khaled, Ibrahim, Ahmed mohamed Ibrahim, Ammar, Gado, Usama Hantour (Al-Hussein Hospital), Esraa Alm Eldeen, Mohamed Reda loaloa, Arwa, Abouzaid, Mostafa Ahmed Bahaa Eldin, Eman, Hashad, Fathy, Sroor, Doaa, Gamil, Eman Mahmoud Abdulhakeem, Mahmoud, Zakaria, Fawzy, Mohamed, Marwan, Abubakr, Elsayed, Ali, Hesham, Magdy, Menna Tallah Ramadan, Mohamed Abdelaty Mohamed, Salma, Mansour, Hager Abdul Aziz Amin, Ahmed Rabie Mohamed, Mahmoud, Saami, Nada Ahmed Reda Elsayed, Adham, Tarek, Sabry Mohy Eldeen Mahmoud, Islam Magdy El Sayed, Amira, Reda, Martina Yusuf Shawky, Mohammed Mousa Salem, Shahinaz Alaa El-Din, Noha Abdullah Soliman, Muhammed, Talaat, Shahinaz, Alaael-Dein, Ahmed Abd Elmoen Elhusseiny, Noha, Abdullah, Mohammed, Elshaar, Aya AbdelFatah Ibraheem, Hager, Abdulaziz, Mohammed Kamal Ismail, Mona Hamdy Madkor, Mohamed, Abdelaty, Sara Mahmoud Abdel-Kader, Osama Mohamed Salah (Benha Faculty Of Medicine), Mahmoud, Eldafrawy, Ahmed Zaki Eldeeb, Mostafa Mahmoud Eid (October, 6 University Hospital), Attia, Attia, Ayman Shwky (Bab El-Shareia University Hospital), Mohamed Adel Badenjki, Abdelrahman, Soliman, Samaa Mahmoud Al Attar (The Memorial Soaad Kafafi University Hospital), Farrag, Sayed, Fahd Abdel Sabour, Azizeldine, Mohammed G., Muhammad, Shawqi, Abdullah, Hashim, Ahmed, Aamer, Ahmed Mahmoud Abdelraouf, Mahmoud, Abdelshakour, Amal, Ibrahim, Basma, Mahmoud, Mohamed Ali Mahmoud, Mostafa, Qenawy, Rashed, Ahmed M., Ahmed, Dahy, Marwa, Sayed, Shamsedine, Ahmed W., Bakeer, Mohamed, Ahmad, Hasan, Saad, Mahmoud M., Khalil Abdul Bassit (Assiut University Hospital), Nadia Khalid Abd El-Latif, Nada, Elzahed, Ahmed El Kashash, Nada Mohamed Bekhet, Sarah, Hafez, Ahmed, Gad, Mahmoud Elkhadragy Maher, Ahmed Abd Elsameea, Mohamed, Hafez, Ahmad, Sabe, Ataa, Ahmed, Ahmed, Shahine, Khaled, Dawood, Shireen, Gaafar, Reem, Husseiny, Omnia, Aboelmagd, Ahmed, Soliman, Nourhan, Mesbah, Hossam, Emadeldin, Amgad Al Meligy, Amira Hassan Bekhet, Doaa, Hasan, Khaled, Alhady, Ahmad Khaled Sabe, Elnajjar, Mahmoud A., Majed, Aboelella, Ward, Hamsho, Ihab, Hassan, Hala, Saad, Galaleldin, Abdelazim, Hend, Mahmoud, Noha, Wael, Ahmedali, M Kandil, Ahmed, Magdy, Shimaa Said Elkholy, Badr Eldin Adel, Kareem, Dabbour, Saged, Elsherbiney, Omar, Mattar, Abdulshafi Khaled Abdrabou, Mohammed Yahia Mohamed Aly, Abdelrahman, Geuoshy, Ahmedglal, Elnagar, Saraibrahim, Ahmed, Ibrahem, Abdelmotaleb, Amr Ahmed Saleh, Manar, Saeed, Shady, Mahmoud, Badreldin Adel Tawfik, Samar Adel Ismail, Esraay, Zakaria, Gad‏, Mariam O., Mohamed Salah Elhelbawy, Monica, Bassem, Noha, Maraie, Nourhan Medhat Elhadary, Nourhan, Semeda, Shaza Rabie Mohamed, Hesham Mohammed Bakry, AA Essam (Kasr Al-Ainy Faculty Of Medicine, Cairo, University), Dina, Tarek, Khlood, Ashour, Alaa, Elhadad, Abdulrahman, Abdel-Aty, Ibrahim, Rakha, Sara Mamdouh Matter, Rasha, Abdelhamed, Omar, Abdelkader, Ayat, Hassaan, Yasmin, Soliman, Amna, Mohamed, Sara Amr Mohamed Farouk, Eman Mohamed Ibrahim, Esraa El-Taher (Faculty Of Medicine Seuz Canal University), Merna, Mostafa, Mohamed Fawzy Mahrous Badr, Rofida, Elsemelawy, Aya, El-Sawy, Ahmad, Bakr, Ahmad Abdel Razaq Al Rafati (Smouha University Hospital), Estonia: Sten Saar, Arvo, Reinsoo, Peep Talving (The North Estonia Medical Centre), Ethiopia: Nebyou Seyoum, Tewodros, Worku, Agazi Fitsum (Addis Ababa University, College Of Health Sciences, School Of Medicine), Finland: Matti Tolonen, Ville Sallinen (Helsinki University Hospital), France: Benoît Parmentier, Matthieu, Peycelon, Sabine Irtan (Trousseau Hospital, APHP), Sabrina Dardenne, Elsa Robert (GHICL), Betty, Maillot, Etienne, Courboin, Alexis Pierre Arnaud, Juliette Hascoet (CHU Rennes), Amir Ait Kaci, Thomas Prudhomme (CHU Toulouse), Quentin, Ballouhey, Céline, Grosos, Laurent Fourcade (CHU Limoges), Tolg, Cecilia, Colombani, Jean-Francois, Francois-Coridon Helene (CHU Martinique), Xavier Delforge, Elodie Haraux (CHU Amiens Picardie), Bertrand, Dousset, Roberto, Schiavone, Sebastien Gaujoux (Cochin, - APHP), Jean-Baptiste, Marret, Aurore, Haffreingue, Julien Rod (CHU Caen), Mariette Renaux-Petel (CHU Rouen), Jean-François, Lecompte, Jean, Bréaud, Pauline Gastaldi (CHU Lenval Nice), Chouikh, Taieb, Raquillet, Claire, Echaieb Anis (Hopital Robert Ballanger, Paris), Nasir, Bustangi, Manuel, Lopez, Aurelien Scalabre (CHU De Saint Etienne), Maria Giovanna Grella (CHU Poitiers), Aurora, Mariani, Guillaume, Podevin, Françoise Schmitt (CHU Angers), Aline, Broch, Cecile Muller (Hopital Necker Enfants Malades, Ghana: Stephen Tabiri, APHP)., Dickson, Bandoh, Francis, Abantanga, Martin, Kyereh, Hamza, Asumah, Eric Kofi Appiah, Paul Wondoh (Tamale Teaching Hospital), Adam, Gyedu, Charles, Dally, Kwabena, Agbedinu, Michael, Amoah, Abiboye Yifieyeh (Kwame Nkrumah University of Science and Technology/Komfo Anokye Teaching Hospital), Particks Hospital), Frank Owusu (St., Mabel, Amoako-Boateng, Makafui, Dayie, Richmond, Hagan, Sam Debrah (Cape Coast Teaching Hosital), Micheal, Ohene-Yeboah, Joe-Nat, Clegg-Lampety, Victor, Etwire, Jonathan, Dakubo, Samuel, Essoun, William, Bonney, Hope, Glover-Addy, Samuel, Osei-Nketiah, Joachim, Amoako, Niiarmah, Adu-Aryee, William, Appeadu-Mensah, Antoinette, Bediako-Bowan, Florence Dedey (Korle Bu Teaching Hospital), Mattew, Ekow, Emmanuel, Akatibo, Musah Yakubu (Baptist Medical Center, Nalerigu), Hope Edem Kofi Kordorwu, Kwasi, Asare-Bediako, Enoch Tackie (Keta Hospital District Hospital, Keta), Kenneth, Aaniana, Emmanuel, Acquah, Richard, Opoku-Agyeman, Anthony, Avoka, Kwasi, Kusi, Kwame Maison (Techiman Holy Family Hospital), Frank Enoch Gyamfi (Berekum Holy Family Hospital), Gandau Naa Barnabas, Saiba Abdul-Latif (Upper West Regional Hospital), Philip Taah Amoako (Samapa Government Hospital), Anthony Davor, Victor Dassah (Upper East Regional Hospital), Mary's Hospital), Enoch Dagoe (St., Prince Kwakyeafriyie (Essumejaman Sda Hospital, Dominase), Elliot, Akoto, Eric, Ackom, Ekow Mensah (Dormaa Presbyterian Hospital), Ebenezer Takyi Atkins, Christian Lari Coompson (Brongho-Ahafo Regional Hospital, Sunyani) Greece: Nikolaos Ivros, Christoforos, Ferousis, Vasileios, Kalles, Christos, Agalianos, Ioannis, Kyriazanos, Christos, Barkolias, Angelos, Tselos, Georgios, Tzikos, Evangelos Voulgaris (Naval And Veterans Hospital), Dimitrios, Lytras, Athanasia, Bamicha, Kyriakos Psarianos (Achillopoyleio General Hospital Of Volos), Anastasios Stefanopoulos (General Hospital Of Nafplio, Department Of Surgery), Ioannis, Patoulias, Dimitrios, Sfougaris, Gennimatas Hospital), Ioannis Valioulis (G., Dimitrios, Balalis, Dimitrios, Korkolis, Dimitrios, K Manatakis (Saint Savvas Cancer Hospital), Georgios, Kyrou, Georgios, Karabelias, Iason-Antonios Papaskarlatos (General And Oncological Hospital Of Kifissia-Athens), Kolonia, Konstantina, Nikolaos, Zampitis, Stylianos Germanos (General Hospital Of Larissa), Aspasia, Papailia, Theodosios, Theodosopoulos, Georgios Gkiokas (2nd Dept Of Surgery, Aretaieion, Hospital, National, &amp, Kapodistrian University Of Athens School Of Medicine), Magdalini, Mitroudi, Christina, Panteli, Thomas, Feidantsis, Gennimatas General Hospital), Konstantinos Farmakis (G., Dimitrios, Kyziridis, Orestis, Ioannidis, Styliani Parpoudi (4th Surgical Department, Aristotle University Of Thessaloniki, General, Hospital, Papanikolaou), Georgios Gemenetzis, Stavros Parasyris (Attikon University Hospital), Michail Margaritis (Serres General Hospital), Guatemala: Maria-Lorena Aguilera-Arevalo, Otto, Coyoy-Gaitan, Javier Rosales (Hospital General San Juan De Dios), Luis, Tale, Emmanuel Barrios (Juan Josè Arevalo Bermejo), Servio Tulio Torres Rodriguez, Carlos Paz Galvez, Danilo Herrera Cruz (Hospital San Vicente), Guillermo Sanchez Rosenberg, Alejandro, Matheu, David Monterroso Cohen (Hospital Herrera Llerandi), Haiti: Marie Paul, Angeline Charles (Hopital Universitaire De Mirebalais), Hong Kong SAR, China: Justin Chak Yiu Lam, Man Hon Andrew Yeung, Chi Ying Jacquelyn Fok, Ka Hin Gabriel Li, Anthony Chuk-Him Lai, Yuk Hong Eric Cheung, Hong Yee Wong, Ka Wai Leung, Tien Seng Bryan Lee, Wai Him Lam, Weihei, Dao, Stephanie Hiu-wai Kwok, Tsz-Yan Katie Chan, Yung Kok Ng, TWC Mak (Prince Of Wales Hospital), Qinyang, Liu, Chi Chung Foo, James Yang (University Of Hong Kong), India: Basant Kumar, Ankur, Bhatnagar, Vijaid Upadhyaya (Sanjay Gandhi Post Graduate Institute Of Medical Sciences), Sunil Kumar (Excelcare Hospital), Uday, Muddebihal, Wasim, Dar, KC Janardha (Manipal Hospital), Philip Alexander, Neerav Aruldas (Lady Willingdon Hospital), Indonesia: Fidelis Jacklyn Adella, Anthonius Santoso Rulie, Ferdy, Iskandar, Jonny Setiawan (Atma Jaya Hospital), Cicilia Viany Evajelista, Hani, Natalie, Oen Surakarta Hospital), Arlindawati Suyadi (Dr., Rudy, Gunawan, Herlin, Karismaningtyas, Lusi Padma Sulistianingsih Mata, Ferry Fitriya Ayu Andika, Afifatun, Hasanah, T Ariani Widiastini, Nurlaila Ayu Purwaningsih, Annisa Dewi Fitriana Mukin, Dina Faizatur Rahmah, Hazmi Dwinanda Nurqistan, Hasbi Maulana Arsyad, Novia Adhitama (Rsd Dr Soebandi), Wifanto Saditya Jeo, Nathania, Sutandi, Audrey, Clarissa, Phebe Anggita Gultom, Matthew, Billy, Andreass, Haloho, Nadya, Johanna, Felix Lee (Rsupn Cipto Mangunkusumo), Ireland: Radin Mohd Nurrahman Radin Dorani, Martha, Glynn, Mohammad, Alherz, Wennweoi, Goh, Shiwani, Haaris A., Lorraine, Sproule, Conlon (Tallaght Hospital, Kevin C., Trinity College Dublin) Israel: Miklosh Bala, Asaf Kedar (Hadassah Hebrew University Medical Center), Italy: Luca Turati, Federica, Bianco, Francesca Steccanella (Treviglio Hospital), Gaetano, Gallo, Mario, Trompetto, Giuseppe Clerico (Department of Colorectal Surgery, Rita Clinic, S., Vercelli), Matteo, Papandrea, Giuseppe, Sammarco, Rosario Sacco (Department of Medical and Surgical Sciences, Policlinico Universitario Mater Domini Campus Salvatore Venuta, Catanzaro), Luisa Giavarini (Sant'Antonio Abate Hospital, Mariano Cesare Giglio, Luigi, Bucci, Gianluca, Pagano, Viviana, Sollazzo, Roberto, Peltrini, Gaetano Luglio (Federico II University Of Naples), Arianna, Birindelli, Gregorio Tugnoli (Maggiore Hospital), Pietro, Mingrone, Domenica Pata (Nicola Giannettasio Hospital, Rossano), Francesco, Selvaggi, Lucio, Selvaggi, Gianluca, Pellino, Natale Di Martino (Universitá della Campania 'Luigi Vanvitelli', Naples), Gianluca, Curletti, Paolo, Aonzo, Raffaele Galleano (Ospedale Santa Corona, Pietra Ligure (SV)), Stefano, Berti, Elisa, Francone, Andrea Hospital, Silvia Boni (S., Poll-Asl, 5, Spezia), La, Lorenzon, Laura, Annalisa lo Conte, Genoveffa Balducci (Sant’Andrea Hospital, Sapienza University of Rome), Gianmaria Confalonieri, Giovanni Pesenti (Azienda Ospedaliera Alessandro Manzoni), Laura, Gavagna, Giorgio, Vasquez, Simone, Targa, Savino, Occhionorelli, Dario Andreotti (Azienda Ospedaliero-Universitaria Di Ferrara), Andrea, Armellini, Spedali Civili Di Brescia), Deborah Chiesa (A. O., Fabrizio, Aquilino, Nicola, Chetta, Arcangelo Picciariello (Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari), Mohamed, Abdelkhalek, Andrea, Belli, Silvia De Franciscis (Istituto Nazionale Tumori Fondazione, Pascale-, I. R. C. C. S. )., Annamaria, Bigaran, Alessandro, Favero, 5 Friuli Occidentale), Stefano M. M Basso (Azienda Per L'assistenza Sanitaria N., Paola, Salusso, Martina, Perino, Sylvie, Mochet, Diego, Sasia, Francesco, Riente, Marco Migliore (Azienda Sanitaria Ospedaliera San Luigi Gonzaga), David, Merlini, Silvia, Basilicò, Carlo Corbellini (Ospedale Di Rho, - ASST Rhodense), Veronica, Lazzari, Luigi Bonavina (IRCCS Policlinico, University of Milano, San, Donato), Daniele, Angelieri, Diego, Coletta, Federica, Falaschi, Marco, Catani, Claudia, Reali, Mariastella, Malavenda, Celeste Del Basso, Sergio, Ribaldi, Massimo, Coletti, Andrea, Natili, Norma, Depalma, Immacolata, Iannone, Angelo, Antoniozzi, Davide Rossi (Policlinico Umberto, I Emergency Surgery Department), Daniele, Gui, Gerardo, Perrotta, Matteo, Ripa, Francesco Ruben Giardino, Maurizio Foco (Fondazione Policlinico Universitario Agostino Gemelli), Erika, Vicario, Gabriela Elisa Nita (AO Papa Giovanni XXIII), Nicoletta, Leone, Anna Maffioli (Ospedale Sacco), Andrea, Simioni, Davide De Boni, Sandro Pasquali (IOV, - Istituto Oncologico Veneto), Elena, Goldin, Elena, Vendramin, Eleonora Ciccioli (Azienda Ospedaliera di Padova), Umberto, Tedeschi, Paola, Violi, Tommaso, Campagnaro, Simone, Conci, Giovanni, Lazzari, Calogero, Iacono, Alfredo, Gulielmi, Serena Manfreda (Azienda Ospedaliera Universitaria Integrata di Verona), Anna, Rinaldi, Maria Novella Ringressi, Beatrice Brunoni (Azienda Ospedaliera Universitaria Careggi), Giuseppe, Salamone, Mirko, Mangiapane, Paolino De Marco, Antonella La Brocca, Roberta, Tutino, Vania, Silvestri, Leo, Licari, Tommaso, Fontana, Nicolò, Falco, Gianfranco Cocorullo (Policlinico Paolo Giaccone di Palermo), Mostafa, Shalaby, Pierpaolo, Sileri, Claudio Arcudi (Policlinico Tor Vergata Hospital, Rome) Jordan: Isam Bsisu, Khaled, Aljboor, Lana, Abusalem, Aseel, Alnusairat, Ahmad, Qaissieh, Emad, Al-Dakka, Ali, Ababneh, Oday Halhouli (Jordan University Hospital), Kenya: Taha Yusufali, Hussein Mohammed (Kenyatta National Hospital), Justus, Lando, Robert, Parker, Wairimu Ndegwa (Tenwek Hospital), Lithuania: Mantas Jokubauskas, Jolanta, Gribauskaite, Donatas Venskutonis (Lithuanian University Of Health Sciences), Justas, Kuliavas, Audrius, Dulskas, Samalavicius (Klaipeda University Hospital, Narimantas E., National Cancer Institute), Kristijonas, Jasaitis, Audrius, Parseliunas, Viktorija, Nevieraite, Evelina, Slapelyte, Edvinas, Dainius, Zilvinas, Dambrauskas, Andrejus, Subocius, Linas, Venclauskas, Antanas, Gulbinas, Simona, Kasputyte, Deimante, Mikuckyte, Mindaugas, Kiudelis, Tomas, Jankus, Steponas Petrikenas (Lithuanian University of Health Sciences), Matas, Pažuskis, Zigmantas, Urniežius, Mantas Vilčinskas (Republican Hospital of Kaunas), Vincas Jonas Banaitis, Vytautas, Gaižauskas, Edvard, Grisin, Povilas, Mazrimas, Mantas, Drungilas, Karolis, Lagunavicius, Vytautas, Lipnickas, Dovilè, Majauskyté, Tomas, Abaliksta, Laimonas, Uščinas, Gintaras, Simutis, Adomas, Ladukas, Donatas, Danys, Erikas, Laugzemys, Elena Zdanyte Sruogiene (Vilnius University Hospital), Petras, Višinskas, Reda, Žilinskienė, Deividas Dragatas (Hospital Of Jonava), Andrius Burmistrovas, Zygimantas Tverskis (Taurage Hospital), Arturas, Vaicius, Ruta, Mazelyte, Antanas Zadoroznas (Viesoji Istaiga Rokiskio Rajono Ligonine), Nerijus Kaselis, Greta Žiubrytė (Republican Hospital Of Klaipeda), Madagascar: Finaritra Casimir Fleur Prudence Rahantasoa, Luc Hervé Samison, Fanjandrainy, Rasoaherinomenjanahary, Todisoa Emmanuella Christina Tolotra (Joseph Ravoahangy Andrianavalona Hospital), Malawi: Cornelius Mukuzunga, Vanessa, Msosa, Chimwemwe, Kwatiwani, Nelson Msiska (Kamuzu Central Hospital), Malaysia: Feng Yih Chai, Siti Mohd Desa Asilah, Khuzaimah Zahid Syibrah (Hospital Keningau), Pui Xin Chin, Nur Zulaika Riswan (Kajang Hospital), Hoong-Yin, Chong, Nora Abdul Aziz, Keat-Seong, Poh, Chu-Ann, Chai, Sandip Kumar (University Malaya Medical Centre), Mustafa Mohammed Taher, Dayang Nita Abdul Aziz, Reynu Rajan (Universiti Kebangsaan Malaysia Medical Centre UKMMC), Rokayah, Julaihi, Durvesh Lacthman Jethwani, Muhammad Taqiyuddin Yahaya, Nik Azim Nik Abdullah, Susan Wndy Mathew, Kuet Jun Chung, Milaksh Kumar Nirumal, Goh Ern Tze, R., Syed Abdul Wahhab Eusoffee Wan Ali (Sarawak General Hospital), Yiing Yee Gan, Jesse Ron Swire Ting (Hospital Sibu), Sii, Samuel S. Y., Kean Leong Koay, Yi Koon Tan, Alvin Ee Zhiun Cheah, Chui Yee Wong, Tuan Nur'Azmah Tuan Mat, Crystal Yern Nee Chow, Har, Prisca A. L., Yishan Der (Hospital Sultanah Aminah), Yong Yong Tew, Fitjerald, Henry, Xinwei Low (Selayang Hospital), Ya Theng Neo, Hian Ee Heng, Shu Ning Kong, Cheewei, Gan, Yi Ting Mok, Yee Wen Tan, Kandasami, Palayan, Mahadevan Deva Tata, Yih Jeng Cheong (Hospital Tuanku Ja'afar), Kuhaendran, Gunaseelan, Wan Nurul 'Ain Wan Mohd Nasir, Pigeneswaren Yoganathan (Hospital Keningau), Eu Xian Lee, Jian Er Saw, Li Jing Yeang, Pei Ying Koh, Shyang Yee Lim, Shuang Yi Teo (Hospital Pulau Pinang, / Penang Medical College), Malta: Nicole Grech, Daniela, Magri, Kristina, Cassar, Christine, Mizzi, Malcolm, Falzon, Nihaal, Shaikh, Ruth, Scicluna, Stefan, Zammit, Sean, Mizzi, Svetlana Doris Brincat, Thelma, Tembo, Vu Thanh Hien Le, Tara, Grima, Keith, Sammut, Kurt, Carabott, Ciskje, Zarb, Andre, Navarro, Thea, Dimech, Georgette Marie Camilleri, Isaac, Bertuello, Jeffrey, Dalli, Karl Bonavia (Mater Dei Hospital), Mexico: Samantha Corro-Diaz, Marisol, Manriquez-Reyes, Antonio Ramos-De la Medina (Hospital Español de Veracruz), Morocco: Amina Abdelhamid, Abdelmalek, Hrora, Sarah, Benammi, Houda, Bachri, Meryem, Abbouch, Khaoula, Boukhal, Redouane Mammar Bennai, Abdelkader, Belkouchi, Mohamed Sobhi Jabal, Chaymae Benyaiche (IBN Sina Hospital) Netherlands: Maarten Vermaas, Lucia Duinhouwer (Ijsselland Hospital) Nicaragua: Javier Pastora, Greta, Wood, Maria Soledad Merlo (Hospital Escuela Oscar Danilo Rosales Arguello), Nigeria: Akinlabi Ajao, Omobolaji, Ayandipo, Taiwo, Lawal, Abdussemiu Abdurrazzaaq (University College Hospital, Ibadan), Muslimat, Alada, Abdulrasheed, Nasir, James, Adeniran, Olufemi, Habeeb, Ademola Adeyeye (University Of Ilorin Teaching Hospital, Ilorin), Ademola, Adebanjo, Adewale Adeniyi (Federal Medical Centre, Abeokuta, ), Henry, Mendel, Bashir, Bello, Umar Muktar (Usmanu Danfodiyo University Teaching Hospital), Thomas Olagboyega Olajide, Oyindamola, Oshati, George, Ihediwa, Babajide, Adenekan, Victor, Nwinee, Abdulrazzaq, Lawal, Chris, Bode, Mojolaoluwa Olugbemi (Lagos University Teaching Hospital), Oluwatomi, Odutola, Oluwaseyi, Adebola, Clement, Onuoha, Fatai, Balogun, Olalekan, Ajai, Iloba, Njokanma, Roland Osuoji (Lagos State University Teaching Hospital), Stephen, Kache, Jonathan, Ajah, Jerry Makama (Barau Dikko Teaching Hospital, Kaduna State University, Kaduna), Ahmed, Adamu, Suleiman, Baba, Mohammad, Aliyu, Shamsudeen, Aliyu, Yahaya, Ukwenya, Halima, Aliyu, Tunde, Sholadoye, Muhammad, Daniyan, Oluseyi Ogunsua (Ahmadu Bello University Teaching Hospital Zaria), Abdurrahaman, Sheshe, Aminu Mohammad (Aminu Kano Teaching Hospital), Samson, Olori, Philip, Mshelbwala, Garba, Samson, Oyediran Kehinde Timothy, Sani Ali Samuel (University Of Abuja Teaching Hospital, Anthony, Ajiboye, Isaac, Amole, Olajide, Abiola, Akin Olaolorun (Bowen University Teaching Hospital), Norway: Kjetil Søreide, Torhild, Veen, Arezo, Kanani, Kristian, Styles, Ragnar, Herikstad, Johannes Wiik Larsen, Jon Arne Søreide (Stavanger University Hospital), Elisabeth, Jensen, Mads, Gran, Eirik Kjus Aahlin (University Hospital Of Northern Norway), Tina, Gaarder, Peter Wiel Monrad-Hansen, Pål Aksel Næss (Oslo University Hospital), Giedrius, Lauzikas, Joachim, Wiborg, Silje Holte (Sykehuset Telemark HF), Knut Magne Augestad, Gurpreet Singh Banipal, Thomas Tetens Moe, Johannes Kurt Schultz (Akershus University Hospital), Palestine: Taher Al-taher, Ayah, Hamdan, Ayman, Salman, Rana, Saadeh, Aseel, Musleh, Dana, Jaradat, Soha, Abushamleh, Sakhaa, Hanoun, Amjad Abu Qumbos, Aseel, Hamarshi, Ayman And Taher (Al Makassed Islamic Charitable Society Hospital, Jerusalem), Israa, Qawasmi, Khalid, Qurie, Marwa, Altarayra, Mohammad, Ghannam, Alaa, Shaheen, Azher Herebat (Alia Governmental Hospital), Aram, Abdelhaq, Ahmad, Shalabi, Maram, Abu-toyour, Fatema, Asi, Ala, Shamasneh, Anwar, Atiyeh, Mousa, Mustafa, Rula, Zaa'Treh, Majd Dabboor (Palestine Medical Complex), Enas, Alaloul, Heba, Baraka, Jehad, Meqbil, Alaa, Al-Buhaisi, Mohamedraed, Elshami, Samah, Afana, Sahar, Jaber, Said, Alyacoubi, Yousef Abuowda (Islamic University of Gaza Medical School, European Gaza Hospital &amp, Shifa, Hospital), Tasneem Idress, Eman Abuqwaider (Mizan hospital), Sara, Al-saqqa, Alaa, Bowabsak, Alaa El Jamassi, Doaa, Hasanain, Hadeel, Al-farram, Maram, Salah, Aya, Firwana, Marwa, Hamdan, Israa Awad (Al-Shifa Hospital), Ahmad Ashour, Fayez Elian Al Barrawi (Bit Hanoun Hospital), Ahmed, Al-khatib, Maha, Al-faqawi, Mohamed Fares (Nasser Hospital), Amjad, Elmashala, Mohammad, Adawi, Ihdaa Adawi (Beit Jala Governmental Hospital), Reem, Khreishi, Rose Khreishi (Martyr Thabet Govermental hospital, Tulkarem), Ahmad, Ashour, Ahed Ghaben (Indonesian Hospital, Gaza) Pakistan: Najwa Nadeem, Muhammad Saqlain (Allied Hospital, Faisalabad), Jibran, Abbasy, Abdul Rehman Alvi, Tanzeela, Gala, Noman Shahzad (Aga Khan University), Kamran Faisal Bhopal, Muhammad Talha Butt, Syed Asaat ul Razi, Asdaq, Ahmed, Ali Khan Niazi (Bahawal Victoria Hospital), Ibrahim, Raza, Fatima, Baluch, Ahmed, Raza, Ahmad, Bani-Sadar, Muhammad, Adil, Awais Raza (King Edward Medical University, Mayo, Hospital, Lahore), Mahnoor, Javaid, Muhammad, Waqar, Maryam Ali Khan (CMH Lahore Medical And Dental College), Mohammad Mohsin Arshad, Mohammadasim Amjad (Nishtar Medical College And Hospital), Paraguay: Gustavo Miguel Machain Vega, Jorge Torres Cardozo, Marcelo O´Higgins Roche, Gustavo Rodolfo Pertersen Servin, Helmut Alfredo Segovia Lohse, Larissa Ines Páez Lopez, Ramón Augusto Melo Cardozo (Hospital de Clínicas, II Cátedra de Clínica Quirúrgica, Universidad Nacional de Asunción) Peru: Fernando Espinoza, Angel David Pérez Rojas, Diana, Sanchez, Camila Sanchez Samaniego, Shalon Guevara Torres, Alexander Canta Calua, Cesar, Razuri, Nadia, Ortiz, Xianelle, Rodriguez, Nahilia, Carrasco, Fridiz, Saravia, Hector Shibao Miyasato, María, Valcarcel-Saldaña, Ysabel Esthefany Alejos Bermúdez, Juan, Carpio, Walter Ruiz Panez, Pedro Angel Toribio Orbegozo (Hospital Nacional Arzopispo Loayza), Carolina Guzmán Dueñas, Kevin Turpo Espinoza, Ana Maria Sandoval Barrantes, Jorge Armando Chungui Bravo, Lorena, Fuentes-Rivera, Carmen, Fernández, Bárbara, Málaga, Joselyn Ye (Hospital Cayetano Heredia), Ricardo Velasquez, Jannin Salcedo (Clínica De Especialidades Médicas), Ana Lucia Contreras-Vergara, Angelica Genoveva Vergara Mejia, Maria Soledad Gonzales Montejo (Hospital Nacional Guillermo Almenara Irigoyen), Marilia Del Carmen Escalante Salas, Willy Alcca Ticona, Marvin, Vargas, George Christian Manrique Sila, Robinson, Mas, Arazzelly del Pilar Paucar (Hospital Regional De Ayacucho), Armando José Román Velásquez, Alina, Robledo-Rabanal, Ludwing Alexander Zeta Solis (Hospital III José Cayetano Heredia), Kenny Turpo Espinoza (Hospital Nacional Maria Auxiliadora), José Luis Hamasaki Hamaguchi, Erick Samuel Florez Farfan, Linda Alvi Madrid Barrientos, Juan Jaime Herrera Matta (Hospital De Policia), Mora, Philippines: John Jemuel V., Redota, Menold Archee P., Manuel Francisco Roxas, Maño (The Medical City), Maria Jesusa B., Marie Dione Parreno-Sacdalan, Christel Leanne Almanon (Department Of Surgery, Philippine General Hospital, University Of The Philippines Manila), Poland: Maciej Walędziak, Rafał, Roszkowski, Michał Janik (Department Of General, Oncological, Metabolic And Thoracic Surgery, Military Institute Of Medicine, Warsaw), Anna, Lasek, Piotr, Major, Dorota, Radkowiak, Mateusz Rubinkiewicz (2nd Department Of Surgery, Jagiellonian University Medical College), Portugal: Cristina Fernandes, Renato Melo (Centro Hospitalar De São João), Romania: Liviu Muntean, Aurel Sandu Mironescu, Lucian Corneliu Vida (Spitalul Clinic De Copii Brasov), Amar Kourdouli, Mariuca Popa (Spital Judetean De Urgenta Din Craiova), Hogea Mircea (Spitalul Clinic Judetean Brasov), Mihaela, Vartic, Bogdan, Diaconescu, Matei Razvan Bratu, Ionut, Negoi, Cezar Ciubotaru (Emergency Hospital of Bucharest), Allen Ingabire, Rwanda: J. C., Norbert Uzabumwana (University Teaching Hospital Of Kigali), Dieudonne Duhoranenayo (Kibungo Hospital), San Marino: Elio Jovine, Nicola, Zanini, Giovanni Landolfo (San Marino State Hospital), Saudi Arabia: Murad Aljiffry, Faisal, Idris, Alghamdi, Mohammed Saleh A., Ashraf, Maghrabi, Aroub, Alkaaki, Sondos Turkustani (Department of Surgery, King Abdulaziz University Hospital, Jeddah) Eyad Khalifah, Adel, Albiety, Sarah, Sahel, Reham, Alshareef, Mohammed Najjar (Department of Surgery, King Abdulaziz University Hospital and Oncology Center, Jeddah) Ahmed Alzahrani, Ahmed, Alghamdi, Wedyan Alhazmi (King Fahad Hospital, Jeddah) Ghiath Al Saied, Mohammed, Alamoudi, Muhammed Masood Riaz (King Fahad Medical City, Mazen, Hassanain, Basmah, Alhassan, Abdullah, Altamimi, Reem, Alyahya, Norah Al Subaie, Fatema Al Bastawis, Roaa Khan (King Khaled University Hospital), Serbia: Milan Radojkovic, Ljiljana, Jeremic, Milica Nestorovic (Clinic For General Surgery, Clinical Center Nis), Singapore: Jia Hao Law, Keith Say Kwang Tan, Ryan Choon Kiat Tan, Joel Kin Tan, Lau Wen Liang Joel, Bettina, Lieske, Xue Wei Chan, Faith Qi Hui Leong, Choon Seng Chong, Sharon, Koh, Kai Yin Lee, Kuok Chung Lee (National University Hospital) South Africa: Kent Pluke, Britta, Dedekind, Puyearashid, Nashidengo, Mark Ian Hampton (Victoria Hospital Wynberg), Johanna, Joosten, Sanju, Sobnach, Liana, Roodt, Anthony, Sander, James, Pape, Richard Spence (Groote Schuur), Niveshni Maistry (Charlotte Maxeke Johannesburg Academic Hospital), Phumudzo, Ndwambi, Kamau, Kinandu, Myint Tun (Leratong Hospital), Frederick Du Toit, Quinn, Ellison, Sule, Burger, Grobler, Dc, Lawrence Bongani Khulu (Tembisa Tertiary Provincial Hospital), Rachel, Moore, Vicky, Jennings, Astrid Leusink (Chris Hani Baragwanath Academic Hospital), Nazmie, Kariem, Juan, Gouws, Kathryn, Chu, Heather, Bougard, Fazlin, Noor, Angela Dell (New Somerset Hospital), Stephanie Van Straten (Helen Joseph Hospital, University Of Witwatersrand), Arvin, Khamajeet, Serge Kapenda Tshisola, Kalangu Kabongo (Stanger Hospital), Yoshan, Moodley, Frank, Anderson, Thandinkosi Madiba (Inkosi Albert Luthuli Central Hospital), Flip du Plooy (Mediclinic Potchefstroom), Leila, Hartford, Gareth, Chilton, Parveen Karjiker (Mitchell's Plain District Hospital), Matlou Ernest Mabitsela, Sibongile Ruth Ndlovu (Dr George Mukhari Academic Hospital), Maria Badicel, Robert Jaich (Milpark Hospital) Spain: Jaime Ruiz-Tovar (University Hospital Rey Juan Carlos), Luis, Garcia-Florez, Otero-Díez, Jorge L., Virginia Ramos Pérez, Nuria Aguado Suárez (Hospital Universitario San Agustín), Javier Minguez García, Sara Corral Moreno, Maria Vicenta Collado, Virginia Jiménez Carneros, Javier García Septiem (Hospital Universitario de Getafe), Mariana, Gonzalez, Antonio, Picardo, Enrique, Esteban, Esther, Ferrero, Irene Ortega (Infanta Sofía University Hospital), Eloy, Espin-Basany, Ruth, Blanco-Colino, Valeria Andriola (Hospital Valle De Hebron), Elisa, Contreras, Carmen García Bernardo, Sandra, Sanz, Alberto Miyar de León, Asnel, Dorismé, Joseluis, Rodicio, Aida, Suarez, Jessica, Stuva, Tamara Diaz Vico (Central University Hospital Of Asturias), Laura, Fernandez-Vega, Carla, Soldevila-Verdeguer, Fatima, Sena-Ruiz, Natalia, Pujol-Cano, Paula, Diaz-Jover, José Maria Garcia-Perez, Juan Jose Segura-Sampedro, Cristina, Pineño-Flores, David, Ambrona-Zafra, Andrea, Craus-Miguel, Patricia, Jimenez-Morillas, Angela Mazzella (Hospital Universitario Son Espases), B Jayathilake, Sri Lanka: A., Thalgaspitiya, S. P. B., Wijayarathna, L. S., Wimalge (University Surgical Unit, P. M. S. N., Teaching Hospital Anuradhapura), Kitts And Nevis: Hakeem Ayomi Sanni, St., Aliyu, Ndajiwo, Ogheneochuko Okenabirhie (Joseph, N France Hospital) Sudan: Anmar Homeida, Abobaker, Younis, Omer Abdelbagi Omer, Mustafa, Abdulaziz, Ali, Mussad, Ali Adam (University of Gezira), Sweden: Yucel Cengiz, Ida, Björklund, Sandra Ahlqvist (Sundsvall Hospital), Anders Thorell, Fredrik Wogensen (Ersta Hospital), Arestis Sokratous, Michaela Breistrand (Mora Hospital), Hildur Thorarinsdottir (Helsingborgs Lasarett), Johanna, Sigurdadottir, Maziar, Nikberg, Abbas Chabok (Västmanlands Hospital Västerås), Maria Hjertberg (Department Of Surgery And Department Of Clinical And Experimental Medicine, Linköping, University, Norrköping, Sweden), Peter, Elbe, Deborah, Saraste, Wiktor, Rutkowski, Louise Forlin (Karolinska Universitetssjukhuset, Solna), Karoliina, Niska, Malin Sund (Umea University Hospital) Switzerland: Dennis Oswald, Georgios, Peros, Rafael, Bluelle, Katharina, Reinisch, Daniel, Frey, Adrian Palma (Gzo Spital Wetzikon), Lucius, Zumbühl, Markus Zuber (Kantonsspital Olten), Roger Schmid, Gabriela Werder (Buergerspital Solothurn), Antonio, Nocito, Silke Mahanty (Kantonsspital Baden), Lukas Werner Widmer, Julia, Müller, Alissa Gübeli (Hospital Davos), Grzegorz Zuk (Gzo Spital Wetzikon), Turkey: Osman Bilgin Gulcicek, Yuksel, Altinel, Talar Vartanoglu (Bagcilar Research And Training Hospital), Emin, Kose, Servet Rustu Karahan, Mehmet Can Aydin (Okmeydanı Training And Research Hospital), Nuri Alper Sahbaz, Ilkay, Halicioglu, Sadi Konuk Training And Research Hospital), Halil Alis (Bakirkoy Dr., Ipek, Sapci, Can, Adıyaman, Ahmet Murat Pektaş, Turgut Bora Cengiz, Ilkan, Tansoker, Vedatcan, Işler, Muazzez, Cevik, Deniz, Mutlu, Volkan, Ozben, Berk Baris Ozmen, Sefa, Bayram, Sinem, Yolcu, Berna Buse Kobal, Ömer Faruk Toto, Haluk Cem Çakaloğlu (Acibadem University School of Medicine, Atakent, Hospital), Kagan, Karabulut, Vahit, Mutlu, Bahar Busra Ozkan (Ondokuz Mayis University Medical Faculty), Saban, Celik, Anil, Semiz, Selim, Bodur, Enisburak, Gül, Busra, Murutoglu, Reyyan, Yildirim, Bahadir Emre Baki, Ekin, Arslan, Mehmet, Ulusahin, Ali Guner (Karadeniz Technical University Faculty Of Medicine), United Kingdom: Nathan Walker, Nikhita, Shrimanker, Simon Cole (Royal United Hospital Bath), Ryan Breslin, Ravi Srinivasan (Blackpool Victoria Hospital), Kristina, Hunter, Ahmed Al-Bahrani (Watford General Hospital), Nora Grace Mairs, Alistair, Rocke, Lachlan, Dick, Mobeen Qureshi (Inverclyde Royal Hospital), Debkumar Chowdhury (University Hospital Ayr), Naomi, Wright, Clare, Skerritt, Thomas' Hospitals), Dorothy Kufeji (Guy's And St., Adrienne, Ho, Tharindra, Dissanayake, Athula, Tennakoon, Wadah Ali (Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust), Charlene, Tan, Catrin Jones (Victoria Hospital Kirkcaldy), Stephen, Knight, Dima, Nassif, Abhishek Sharma (Perth Royal Infirmary), Oliver, Warren, Rebecca, White, Aia, Mehdi, Nathan, Post, Eliana, Kalakouti, Enkhbat, Dashnyam, Frederick Stourton (Chelsea And Westminster Hospital), Ioannis Mykoniatis, Chelise Currow (Northampton General Hospital), Francisca, Wong, Ashish, Gupta, Veeranna Shatkar (Queen's Hospital, BHR University Hospitals NHS Trust), Suraj, Kadiwar, Alexander Smedley (North Middlesex University Hospital), Rebecca, Wakefield, Philip, Herrod, James, Blackwell, Jonathan Lund (Royal Derby Hospital), Fraser, Cohen, Ashwath, Bandi, Stefano Giuliani (St George's Hospital), Giles, Bond-Smith, Neda, Farhangmehr, Miklos Perenyei (John Radcliffe Hospital, Oxford), Philip, Ireland, Kirk, Bowling, David Bunting (Gloucestershire Royal Hospital), Lydia, Longstaff, Kenneth Keogh (Royal Devon &amp, Exeter, Hospital), Hyunjin, Jeon, Muhammad Rafaih Iqbal, Shivun, Khosla, Anna, Jeffery, James Perera (Maidstone &amp, Tunbridge Wells NHS Trust), Ella Teasdale (Western Isles Hospital), Tariq, Alhammali, Yahya Salama (Kettering General Hospital NHS Trust), Rakan Kabariti, Shaun Oram (Nevill Hall Hospital), Thomas, Kidd, Fraser, Cullen, Christopher, Owen, Michael, Wilson, Seehui, Chiu, Hannah Sarafilovic (Ninewells Hospital), Jennifer, Ploski, Elizabeth, Evans, Athar, Abbas, Sylvia, Kamya, Norzawani, Ishak, Carly, Bisset, Cedar, Andress, Ye Ru Chin (Royal Alexandra Hospital, Paisley), Priya, Patel, David Evans (University Hospital, Wales), Anna Jeffery, James Perera (Maistone and Tunbridge Wells NHS Trust), Aidan, Haslegrave, Adam, Boggon, Kirsten, Laurie, Thomas Mann (Borders General Hospital), Anahita, Mansuri, Rachel, Davies, Ewen Griffiths (University Hospitals Birmingham NHS Trust), Aized Raza Shahbaz, Calvin, Eng, Farhat, Din, Ariadne, L'Heveder, Park, Esther H. G., Ramanish, Ravishankar, Kirsten, Mcintosh, Jih Dar Yau, Luke, Chan, Susan McGarvie (Western General Hospital, Edinburgh), Lingshan, Tang, Hui, Lim, Suhhuey, Yap, Jay, Park, Zhan Herr Ng, Shahrukh, Mirza, Yun Lin Ang, Luke, Walls, Chloe, Roy, Simon, Paterson-Brown, Julian, Camilleri-Brennan, Kenneth, Mclean, Michelle, S D'Souza, Savva, Pronin, David Ewart Henshall, Eunice Zuling Ter (Royal Infirmary Of Edinburgh), Dina Fouad, Ashish Minocha (Norfolk And Norwich University Hospital), William, English, Catrin, Morgan, Dominic, Townsend, Laura, Maciejec, Shareef, Mahdi, Onyinye, Akpenyi, Elisabeth, Hall, Hanaan, Caydiid, Zakaria, Rob, Tom, Abbott, Hew, D Torrance (The Royal London Hospital), Gareth Irwin, Robin Johnston (Ulster Hospital Dundonald), Mohammed Akil Gani, Gianpiero Gravante (Leicester Royal Infirmary), Shivanchan, Rajmohan, Kiran, Majid, Christopher Smith (West Middlesex University Hospital), Madanmohan, Palliyil, Sanjay, Patel, Luke, Nicholson, Neil, Harvey, Katie, Baillie, Sam, Shillito, Suzanne, Kershaw, Rebecca, Bamford, Peter Orton (Stockport NHS Foundation Trust), Elke, Reunis, Wai Cheong Soon (Good Hope Hospital), Jama, Guled M., Dharminder, Dhillon, Khyati Patel (Walsall Manor Hospital, Walsall), Shayanthan, Nanthakumaran, Rachel, Heard, Kar Yan Chen (Aberdeen Royal Infirmary), Behrad, Barmayehvar, Uttaran, Datta, Sivesh, K Kamarajah, Sharad Karandikar (Heartlands Hospital), Sobhana Iftekhar Tani (Nottingham University Hospital NHS Trust), Philippa, Donnelly, Michael Walker (Raigmore Hospital), Jehangirshaw, Parakh, Sarah, Blacker, Anil Kaul (Whiston Hospital), Arjun Paramasivan (Darlington Memorial Hospital), Sameh, Farag, Ashrafun, Nessa, Salwa Awadallah (Worthing Hospital, Western Sussex Hospital NHS Foundation Trust), Jieqi, Lim, James Chean Khun Ng (Queen Elizabeth University Hospital, Glasgow), United States: Katherine Gash, Kiran, Ravi P., Alice Murray (New York Presbyterian Hospital, / Columbia University Medical Center), Mohini, Dasari, Juan Puyana (University Of Pittsburgh Medical Center, - Presbyterian), Nadeem, Haddad, Martin, Zielinski, Asad Choudhry (Mayo Clinic), Celeste, Caliman, Mieshia, Beamon, Therese Duane (John Peter Smith Hospital), Ragavan Narayanan, Mamta Swaroop (Northwestern Memorial Hospital / Northwestern University), Jonathan, Myers, Rebecca, Deal, Erik Schadde (Rush University Medical Centre), Mark, Hemmila, Kathleen To (University Of Michigan Medical Center) Zambia: Alex Makupe, Joseph, Musowoya, Mayaba Maimbo (Ndola Central Hospital), Niels Van Der Naald, Dayson, Kumwenda, Alex, Reece-Smith, Kars, Otten, Anna, Verbeek, Marloes Prins (St Francis Mission Hospital) Data validators (GlobalSurg-2) Argentina: Alibeth Andres Baquero Suarez (Simplemente Evita), Ruben Balmaceda (Hospital Lagomaggiore), Barbados: Chelsea Deane (Queen Elizabeth Hospital), Croatia: Emilio Dijan (Zadar General Hospital), Egypt: Mahmoud Elfiky (Kasr Al Ainy Faculty of Medicine, Cairo University), Finland: Laura Koskenvuo (Helsinki University Hospital), France: Aurore Thollot (CHU Poitiers), Bernard Limoges (CHU Limoges), Carmen Capito (Hopital Necker Enfants Malades, Challine Alexandre (Hopital Cochin, Henri Kotobi (Trousseau Hospital, Julien Leroux (CHU Rouen), Kalitha Pinnagoda (CHU Toulouse), Nicolas Henric (CHU Angers), Olivier Azzis (CHU Rennes), Olivier Rosello (CHU Nice), Poddevin Francois (GHICL), Sara Etienne (CHU Saint Etienne), Philippe Buisson (CHU Amiens Picardie), Sophian Hmila (Hopital Robert Ballanger, Ghana: Joe-Nat Clegg-Lamptey (Korle Bu Teaching Hospital), Osman Imoro (Baptist Medical Centre), Owusu Emmanuel Abem (Komfo Anokye Teaching Hospital), Paul Wondoh (Upper West Regional Hospital), Greece: Dimitrios Papageorgiou (Naval And Veterans Hospital Of Athens), Vasiliki Soulou (Anticancer Hospital Of Athens Agios Savvas), Guatemala: Sabrina Asturias (Hospital Herrera Llerandi Amedesgua), Lenin Peña (Hospital General San Juan De Dios), India: Basant Kumar (Sanjay Gandhi Post Graduate Institute Of Medical College Lucknow), Ireland: Donal B O’Connor (Tallaght Hospital, Trinity College Dublin), Italy: Alberto Realis Luc (Santa Rita Clinic, Alfio Alessandro Russo (Treviglio Hospital), Andrea Ruzzenente (Azienda Ospedaliera Universitaria Integrata di Verona), Antonio Taddei (Azienda Ospedaliera Universitaria Careggi), Camilla Cona (IOV, - Istituto Oncologico Veneto), Corrado Bottini (Sant'Antonio Abate Hospital, Giovanni Pascale (Azienda Ospedaliero-Universitaria di Ferrara), Giuseppe Rotunno (Nicola Giannettasio Hospital, Leonardo Solaini (University Of Brescia, Spedali Civili Di Brescia, ), Marco Maria Pascale (Fondazione Policlinico Universitario 'Agostino Gemelli', ), Margherita Notarnicola (University Of Bari 'Aldo Moro'), Mario Corbellino (Ospedale Luigi Sacco Milano), Michele Sacco (Federico II University of Naples), 5 'Friuli Occidentale', Paolo Ubiali (Azienda per L'Assistenza Sanitaria N., Pordenone), Roberto Cautiero (Second University Of Naples), Tommaso Bocchetti (Sant’Andrea Hospital, Andrea Hospital, Elena Muzio (S., Vania Guglielmo (Policlinico Umberto I, Emergency Surgery Department), Eugenio Morandi (Ospedale di Rho, – ASST Rhodense), Patrizio Mao (San Luigi Gonzaga Hospital, Orbassano), Emilia De Luca (Department of Medical and Surgical Sciences, Jordan: Farah Mahmoud Ali (Jordan University Hospital), Margherita Notarnicola (Azienda Ospedaliero Universitaria Consorziale Policlinico Di Bari)., Lithuania: Justas Žilinskas (Klaipeda Republic), Kestutis Strupas (Vilnius University Hospital), Paulius Kondrotas (Taurage County Hospital), Robertas Baltrunas (Rokiskis District Municipality Hospital), Juozas Kutkevicius (Department Of General Surgery, Lithuanian University Of Health Sciences), Povilas Ignatavicius (Hospital Of Lithuanian University Of Health Sciences Kaunas Clinics), Malaysia: Choy Ling Tan (Hospital Sultanah Aminah), Jia Yng Siaw (Hospital Sibu), Sir Young Yam (Penang Medical College), Ling Wilson (Sarawak General Hospital), Mohamed Rezal Abdul Aziz (University Malaya Medical Centre), Malta: John Bondin (Mater Dei Hospital), Mexico: Carmina Diaz Zorrilla (Hospital Espanol De Veracruz), Morocco: Anass Majbar (Centre Hospitalier Ibn Sina Rabat), Nigeria: Danjuma Sale (Barau Dikko Teaching Hospital), Lawal Abdullahi (Aminu KanoTeaching Hospital), Olabisi Osagie (University Of Abuja Teaching Hospital), Omolara Faboya (Lagos State Teaching Hospital), Adedeji Fatuga (Lagos University Teaching Hospital), Agboola Taiwo (Babcock University Teaching Hospital), Emeka Nwabuoku (Ahmadu Bello University Teaching Hospital), Norway: Marte Bliksøen (Oslo University Hospital), Pakistan: Zain Ali Khan (Bahawal Victoria Hospital, Bahawalpur), Paraguay: Jazmin Coronel (Hospital de Clínicas, Universidad Nacional de Asunción) Peru: Cesar Miranda (Hospital Nacional Cayetano Heredia), Idelso Vasquez (Lima Almenara), Helguero-Santin (Hospital Regional III Jose Cayetano Heredia – Piura), Luis M., Rwanda: Jennifer Rickard (Centre Hospitalier Universitaire De Kigali), Romania: Aurel Mironescu (Spitalul Clinic De Copii Brasov), Saint Kitts and Nevis: Adesina Adedeji (Joseph, N France Hospital), Saudi Arabia: Saleh Alqahtani (King Fahad General Hospital), South Africa: Max Rath (Groote Schuur Hospital), Michael Van Niekerk (New Somerset Hospital), Modise Zacharia Koto (Dr George Mukhari Academic Hospital), Roel Matos-Puig (Stanger Hospital), Sweden: Leif Israelsson (Sundsvall), Switzerland: Tobias Schuetz (Kantonsspital Olten), Turkey: Mahmut Arif Yuksek (Ondokuz Mayis University), Meric Mericliler (Acibadem University School of Medicine, Mehmet Uluşahin (Karadeniz Technical University Farabi Hospital), United Kingdom: Bernhard Wolf (Raigmore Hospital Inverness), Cameron Fairfield (Royal Infirmary Of Edinburgh), Guo Liang Yong (Perth Royal Infirmary), Katharine Whitehurst (Royal Devon And Exeter), Michael Wilson (Ninewells Hospital And Medical School), Natalie Redgrave (John Radcliffe Hospital, Caroluce, K Musyoka (Royal Alexandra Hospital), James Olivier (Royal United Hospital Bath), Kathryn Lee (Queen Elizabeth Birmingham), Michael Cox (Royal Derby Hospital), Muhamed M, H Farhan-Alanie (Inverclyde Royal Hospital), Rory Callan (North Middlesex University Hospital) Zambia: Chali Chibuye (Ndola Central Hospital) Protocol translators (GlobalSurg-2) Arabic, Tebian Hassanein Ahmed Ali, Syrine, Rekhis, Muna, Rommaneh, Oday, Halhouli, Chinese, Zi Hao Sam, Jacky Hong Chieh Chen, French, Dylan, Roi, Greek, Vasileios Kalles, Italian, Gabriela Elisa Nita, Portuguese, Thays Brunelli Pugliesi, Gabriel, Pardo, Spanish, Ruth, Blanco, Eugenio Grasset, Escobar., Gallo, Gaetano, Adisa, A. O., Costas-Chavarri, A., Allen-Ingabire, J. C., Lilford, R. J., Harrison, E. M., Pinkney, T. D., Verjee, A., Runigamugabo, E., Altamini, A., Borda-Luque, G., Cornick, J., Fitzgerald, J. E., Kirby, A., Mihaljevic, A. L., Morton, D., Ntirenganya, F., Ots, R., Shaw, C. A., Khatri, C., Gobin, N., Freitas, A. V., Hall, N., Kim, S. -H., Negida, A., Jaffry, Z., Chapman, S. J., Arnaud, A. P., Tabiri, S., Recinos, G., Manipal, C. E., Mohan, M., Amandito, R., Shawki, M., Hanrahan, M., Zilinskas, J., Roslani, A. C., Goh, C. C., Ademuyiwa, A. O., Irwin, G., Shu, S., Luque, L., Shiwani, H., Altamimi, A., Alsaggaf, M. U., Spence, R., Rayne, S., Jeyakumar, J., Raptis, D. A., Glasbey, J. C., Modolo, M. M., Iyer, D., King, S., Arthur, T., Nahar, S. N., Waterman, A., Walsh, M., Agarwal, A., Zani, A., Firdouse, M., Rouse, T., Liu, Q., Correa, J. C., Salem, H. K., Talving, P., Worku, M., Kalles, V., Kumar, B., Kumar, S., Quek, R., Pata, F., Ansaloni, L., Altibi, A., Venskutonis, D., Poskus, T., Whitaker, J., Msosa, V., Tew, Y. Y., Farrugia, A., Borg, E., Ramos-De La Medina, A., Bentounsi, Z., Soreide, K., Gala, T., Al-Slaibi, I., Tahboub, H., Alser, O. H., Romani, D., Major, P., Mironescu, A., Bratu, M. R., Kourdouli, A., Ndajiwo, A., Altwijri, A., Gudal, A., Jubran, A. F., Seisay, S., Lieske, B., Ortega, I., Senanayake, K. J., Abdulbagi, O., Altinel, Y., Kong, C., Teasdale, E., Stoddart, M., Kabariti, R., Suresh, S., Gash, K., Narayanan, R., Maimbo, M., Fermani, C., Macdermid, E., Chenn, R., Yong, C. O., Edye, M., Jarmin, M., D'Amours, S. K., Youssef, D., Phillips, N., Brown, J., George, R., Koh, C., Warren, O., Hanley, I., Dickfos, M., Nawara, C., Ofner, D., Primavesi, F., Mitul, A. R., Mahmud, K., Hussain, M., Hakim, H., Kumar, T., Oosterkamp, A., Assouto, P. A., Lawani, I., Souaibou, Y. I., Tun, A. K., Chong, C. L., Devadasar, G. H., Qadir, M. R. M., Aung, K. P., Yeo, L. S., Castillo, V. D. P., Munhoz, M. M., Moreira, G., De Castro Segundo, L. C. B., Ferreira, S. A. K., Careta, M. C., Kim, S. B., De Sousa, A. V., Cury, A. D. L., Miguel, G. P. S., De Freitas, A. V. C., Silvestre, B. P., Vianna, J. G. P., Felipe, C. O., Laufer, L. A. V., Altoe, F., Da Silva, L. A., Pimenta, M. L., Giuriato, T. F., Morais, P. A. B., Luiz, J. S., Araujo, R., Menegussi, J., Leal, M., De Lima, C. V. B., Tatagiba, L. S., Leal, A., Dos Santos, D. V., Fraga, G. P., Simoes, R. L., Stock, S., Nigo, S., Kabba, J., Ngwa, T. E., Azzie, G., Kushwaha, S., Bailey, K., Cameron, B., Livingston, M., Horobjowsky, A., Deckelbaum, D. L., Razek, T., Marinkovic, B., Grasset, E., D'Aguzan, N., Jimenez, J., Macchiavello, R., Zhang, Z., Guo, W., Oh, J., Zheng, F., Montes, I., Sierra, S., Mendez, M., Villegas, M. I., Arango, M. C. M., Mendoza, I., Aristizabal, F. A. N., Botero, J. A. M., Riaza, V. M. 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Fahiem, Ahmed, Sarsik, Sameh, Hashish, Amel, Zidan, Mohamed, Hashish, Mohamed, Aql, Shaimaa, Elhendawy, Abdelaziz Osman Abdelaziz, Husseini, Mohamed, Kasem, Esraa, Gheith, Ahmed, Elfouly, Yasmin, Soliman, Ahmed Ragab, Ibrahim, Yasmein, Elfouly, Nesma, Fawzy, Ahmed, Hassan, Ahmed, Rashid, Mohammad, Elsherbiny, Abdallah Salah, Sieda, Basem, Badwi, Nermin M, Mohammed, Mohammed Mustafa Hassan, Mohamed, Osama, Habeeb, Mohammad Abdulkhalek, Starr, Nichole, Desta, Semay, Wondimu, Sahlu, Abebe, Nebyou Seyoum, Thomas, Efeson, Asele, Frehun Ayele, Dabessa, Daniel, Abebe, Nebiyou Seyoum, Zerihun, Abebe Bekele, Mentula, Panu, Leppäniemi, Ari, Sallinen, Ville, Scalabre, Aurelien, Frade, Fernanda, Irtan, Sabine, Graffeille, Vivien, Gaignard, Elodie, Alimi, Quentin, Graffieille, Vivien, Abbo, Olivier, Mouttalib, Sofia, Bouali, Ourdia, Hervieux, Erik, Aigrain, Yve, Botto, Nathalie, Faure, Alice, Fievet, Lucile, Panait, Nicoleta, Eyssartier, Emilie, Schmitt, Francoise, Podevin, Guillaume, Parent, 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Kylie Joan‐yi, Szeto, Charing Cheuk Ling, Li, Wing Sum, Li, Kieran Ka Kei, Leung, Man Fung, Mak, Tony, Ng, Simon, Prasad, SS, Kirishnan, Anand, Gyanchandani, Nidhi, Kumar, Bylapudi Seshu, Rangarajan, Muthukumaran, Bhat, Sriram, Sreedharan, Anjana, Kinnera, S.V., Reddy, Yella, Venugopal, Caranj, Mittal, Abhishek, Nadkarni, Shravan, Lakshmi, Harish Neelamraju, Malik, Puneet, Limaye, Neel, Pai, Sriniva, Jain, Pratik, Khajanchi, Monty, Satoskar, Savni, Satoskar, Rajeev, Mahamood, Abid Bin, Sutanto, Eldaa Prisca Refianti, Soeselo, Daniel Ardian, Tedjaatmadja, Chintya, Rahmawati, Fitriana Nur, Mayasari, Maria, Al‐Hasani, Ruqaya Kadhim Mohammed Jawad, Al‐Hameedi, Hasan Ismael Ibraheem, Ibraheem, Hasan Ismael, Al‐Azraqi, Israa Abdullah Aziz, Sabeeh, Lubna, Kamil, Rahma, Telfah, Muwaffaq Mezeil, Rasendran, Amoudtha, Sheehan, Jacqueline, Kerley, Robert, Normile, Caoimhe, Gilbert, Richard William, Song, Jiheon, Dablouk, Mohamed, Mauro, Linnea, Dablouk, Mohammed Osman, Kielty, Paul, Marks, Eleanor, Gosling, Simon, Mccarthy, Michelle, Mirghani, Diya, Naqvi, Syed Altaf, Wong, Chee Siong, Chung, Siyi, D'cruz, Reuban, Cahill, Ronan, Gosling, Simon George, Fahy, Ciara, Cadogan, Diana Duarte, Powell, Anna, Gilbert, Richard, Clifford, Caroline, Driscoll, Aoife, Paul, Stassen, Lee, Chri, Bowe, Ro, Hutch, William, Mohan, Helen, O'neill, Maeve, Mealy, Kenneth, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Pasini, Mario, Pata, Giacomo, Roncali, Stefano, Silvani, Paolo, Carlucci, Michele, Faccincani, Roberto, Bonavina, Luigi, Macchitella, Yuri, Ceriani, Chiara, Tugnoli, Gregorio, Di Saverio, Salomone, Khattab, Khaled, Paludi, Miguel Angel, Pata, Domenica, Cloro, Luigi Maria, Allegri, Andrea, Coccolini, Federico, Veronese, Ezio, Bortolasi, Luca, Hasheminia, Alireza, Nastri, Giacomo, Canto, Massimiliano Dal, Cucumazzo, Stefano, Benevento, Angelo, Tessera, Gaetano, Grandinetti, Pier Paolo, Maniscalco, Alessio, Lamanna, Giovanni Luca, Turati, Luca, Sgroi, Giovanni, Rausa, Emanuele, Villa, Roberta, Monteleone, Michela, Merlini, David, Grassi, Veronica, Cirocchi, Roberto, Cacurri, Alban, Waleed, Hamza, Diab, Ahmed, Elzowawi, Fathi, Jokubauskas, Manta, Varkalys, Karoli, Pranevicius, Roberta, Ambrozeviciute, Viktorija, Juciute, Simona, Skardžiukaitė, Austė, Bradulskis, Sauliu, Urbanavicius, Lina, Austraite, Aiste, Riauka, Romualda, Dambrauskas, Zilvina, Karumnas, Pauliu, Urniezius, Zigmanta, Zilinskiene, Reda, Rudzenskaite, Anele, Usaityte, Ausrine, Montrimaite, Margarita, Kaselis, Neriju, Strazdas, Andriu, Jokubonis, Kristijona, Maceviciute, Kornelija, Beisa, Virgiliju, Strupas, Kestuti, Laugzemys, Erika, Kolosov, Andrej, Jotautas, Valdemara, Rakita, Igna, Mikalauskas, Sauliu, Kazanavicius, Dariu, Rackauskas, Roka, Rakauskas, Ritaura, Preckailaite, Egle, Coomber, Ro, Johnson, Kenneth, Nowers, Jennifer, Periasammy, Dineshwary, Salleh, Afizah, Das, Andre, Tze, Reuben Goh Ern, Kumar, Milaksh Nirumal, Abdullah, Nik Azim Nik, Kosai, Nik Ritza, Taher, Mustafa, Rajan, Reynu, Chong, Hoong Yin, Agius, Marija, Bezzina, Maureen, Bugeja, Roberta, Vella‐Baldacchino, Martinique, Spina, Andrew, Psaila, Josephine, Francois‐Coridon, Helene, Tolg, Cecilia, Colombani, Jean‐Francoi, Diaz‐Zorrilla, Carmina, De La Medina, Antonio Ramos‐, Gonzalez, Samantha Corro‐Diaz, Jacobe, Mário, Mapasse, Domingo, Snyder, Elizabeth, Oumer, Ramadan, Osman, Mohammed, Mohammad, Aminu, Anyanwu, Lofty‐John, Sheshe, Abdulrahman, Adesina, Alaba, Faturoti, Olubukola, Taiwo, Ogechukwu, Ibrahim, Muhammad Habib, Nasir, Abdulrasheed A, Suleiman, Siyaka Itopa, Adeniyi, Adewale, Adesanya, Opeoluwa, Adebanjo, Ademola, Osuoji, Roland, Atobatele, Kazeem, Ogunyemi, Ayokunle, Williams, Omolara, Oludara, Mobolaji, Oshodi, Olabode, Ademuyiwa, Adesoji, Lawal, AbdulRazzaq Oluwagbemiga, Alakaloko, Felix, Elebute, Olumide, Osinowo, Adedapo, Bode, Christopher, Adesuyi, Abidemi, Tade, Adesoji, Adekoya, Adeleke, Nwokoro, Collin, Ayandipo, Omobolaji O, Lawal, Taiwo Akeem, Ajao, Akinlabi E, Ali, Samuel Sani, Odeyemi, Babatunde, Olori, Samson, Popoola, Ademola, Adeyeye, Ademola, Adeniran, Jame, Lossius, William J., Havemann, Ingemar, Thorsen, Kenneth, Narvestad, Jon Kristian, Soreide, Kjetil, Wold, Trude Beate, Nymo, Linn, Elsiddig, Mohammed, Dar, Manzoor, Bhopal, Kamran Faisal, Iftikhar, Zainab, Furqan, Muhammad Mohsin, Nighat, Bakhtiar, Jawaid, Masood, Khalique, Abdul, Zil‐E‐Ali, Ahsan, Rashid, Anam, Dharamshi, Hasnain Abba, Naqvi, Tahira, Faraz, Ahmad, Anwar, Abdul Wahid, Yaseen, Tahir Muhammad, Shamsi, Ghina Shamim, Shamsi, Ghina, Yaseen, Tahir, Anwer, Wahid, Decoud, Horacio Parede, Aguilera, Omar, Alvarez, Ismael Isaac Zelada, Delgado, Juan Marcelo, Vega, Gustavo Miguel Machain, Lohse, Helmut Alfredo Segovia, Aguilar, Wendy Leslie Messa, Chiong, Jose Antonio Cabala, Bautista, Ana Cecilia Manchego, Huaman, Eduardo, Zegarra, Sergio, Camacho, Rony, Celis, Jose María Vergara, Pozo, Diego Alonso Romani, Hamasaki, José, Temoche, Edilberto, Herrera‐Matta, Jaime, Torres, Carla Pierina García, Barreda, Luis Miguel Alvarez, Ojeda, Ronald Renato Barrionuevo, Garaycochea, Octavio, Mollo, Melanie Castro, Delgado, Mitchelle Solange De Fã Tima Linare, Fujii, Francisco, Durand, Susana Yrma Aranzabal, Basto, Carlos Alejandro Arroyo, Rojas, Nelson Manuel Urbina, Yip, Sebastian Bernardo Shu, Vergara, Ana Lucia Contrera, Moran, Andrea Echevarria Rosa, Luque, Giuliano Borda, Castro, Manuel Rodriguez, Jaramillo, Ramon Alvarado, Sila, George Manrique, Lopez, Crislee Elizabeth, De Leon, Mardelangel Zapata Ponze, Machaca, Massiell, Huaraya, Ronald Coasaca, Arenas, Andy, López, Crislee, Puma, Clara Milagros Herrera, Pino, Wilfredo, Hinojosa, Christian, De Leon, Melanie Zapata Ponze, Limache, Susan, Sila, George Manrrique, Rodriguez, Layza‐Alejandra Mercado, Melo, Renato, Costa‐Maia, Jose, Muralha, Nuno, Sauvat, Frederique, Dan, Ionasc, Hogea, Mircea, Eduard, Pandi, Bratu, Razvan‐Matei, Beuran, Mircea, Diaconescu, Ionut‐Bogdan, Martian, Bogdan‐Valeriu, Iordache, Florin‐Mihail, Vartic, Mihaela, Vida, Lucian Corneliu, Muntean, Liviu Iuliu, Mironescu, Aurel Sandu, Nsengimana, Vizir Jean Paul, Niragire, Alice, Ingabire, Jean De La Croix Allen, Niyirera, Eugene, Zanini, Nicola, Jovine, Elio, Landolfo, Giovanni, Alomar, Ibrahim N., Alnuqaydan, Saleh A., Altwigry, Abdulrahman M., Othman, Moayad, Osman, Nohad, Alqahtani, Ena, Alzahrani, Mohammed, Alyami, Rifan, Aljohani, Emad, Alhabli, Ibrahim, Mikwar, Zaher, Almuallem, Sultan, Nawawi, Abrar, Bakhaidar, Mohamad, Maghrabi, Ashraf A., Alsaggaf, Mohammed, Aljiffry, Murad, Altaf, Abdulmalik, Khoja, Ahmad, Habeebullah, Alaa, Akeel, Nouf, Ghandora, Nashat, Almoflihi, Abdullah, Huwait, Abdulmalik, Al‐shammari, Abeer, Al‐Mousa, Mashael, Alghamdi, Masood, Adham, Walid, Albeladi, Bandar, Alfarsi, Muayad Ahmed, Mahdi, Atif, Al Awwad, Saad, Nouh, Thamer, Hassanain, Mazen, Aldhafeeri, Salman, Sadig, Nawal, Algohary, Osama, Aledrisy, Mohannad, Alrifaie, Ahmad, AlRowais, Mohammed, Althwainy, Amani, Shabkah, Alaa, Alamoudi, Uthman, Alrajraji, Mawaddah, Alghamdi, Basim, Aljohani, Saud, Daqeeq, Abdullah, Al‐Faifi, Jubran J, Jennings, Vicky, Ngayu, Nyawira, Moore, Rachel, Kong, Victor, Kretzmann, Hayden, Connor, Katie, Nel, Daniel, Sampson, Colleen, Panieri, Eugenio, Sishuba, Nosisa, Tun, Myint, Mphatsoe, Albert Mohale, Carreira, Jo‐Anne, Wagener, Mark, Botes, Stefan, Du Plessis, Danelo, Fernandez‐Bueno, Fernando, Aguilar‐Jimenez, Jose, Garcia‐Marin, Jose Andre, García, Lorena Solar, Florez, Luis Joaquín García, Pacheco, Rubén Darío Aria, Pagnozzi, Janet, Quezada, Jimy Harold Jara, Rodicio, Jose Lui, Minguez, German, Rodríguez‐Uría, Raquel, Ugalde, Paul, Lopez‐Arevalo, Camilo, Barneo, Lui, Stuva, Jessica Patricia Gonzale, Ortega‐Vazquez, Irene, Rodriguez, Lorena, Herrera, Norberto, Arachchi, Prasad Pitigala, Senanayake, Wanigasekara, Senanayake, Mudiyanselage Kithsiri Janakantha, Arachchige, Lalith Asanka Jayasooriya Jayasoori, Sivaganesh, Sivasuriya, Samaraweera, Dulan Irusha, Thanusan, Vimalakanthan, Musa, Ahmed Elgaili Khalid, Balila, Reem Mohammed Hassan, Mohamed, Mohamed Awad Elkarim Hamad, Ali, Hussein, Elabdin, Hagir Zain, Hassan, Alaa, Mahdi, Sefeldin, Ahmed, Hala, Idris, Sahar Abdoun Ishag, Elsayed, Makki, Elsayed, Mohammed, Mahmoud, Mohamed, Boijsen, Magnu, Lundgren, Per‐Olof, Gustafsson, Ulf, Kiasat, Ali, Wogensen, Fredrik, Jurdell, Emma, Thorell, Ander, Thorarinsdottir, Hildur, Utter, Maria, Sundstrom, Sami Martin, Wredberg, Cecilia, Kjellin, Ann, Nyberg, Johanna, Frisk, Bjorn, Sund, Malin, Andersson, Linda, Gunnarsson, Ulf, Cengiz, Yücel, Ahlqvist, Sandra, Björklund, Ida, Royson, Hanna, Weber, Per, Pahlsson, Hans‐Ivar, Borin, Eva, Hjertberg, Maria, Schmid, Roger, Schivo, Debora, Despotidis, Vasileio, Breitenstein, Stefan, Staerkle, Ralph F, Schadde, Erik, Deichsel, Fabian, Gerosa, Alexandra, Nocito, Antonio, Raptis, Dimitri Aristotle, Mijuskovic, Barbara, Zuber, Marku, Eisner, Luka, Kruspi, Swantje, Reinisch, Katharina Beate, Schoewe, Christin, Novak, Allan, Palma, Adrian F., Teufelberger, Gerfried, Kimaro, Msafiri, King, Rachel, Balkan, Ali Zeynel Abidin, Gumar, Mehmet, Yavuz, Mehmet Ali, Karabacak, Ufuk, Lap, Gokhan, Ozkan, Bahar Busra, Karakahya, Murat, Adams, Ryan, Morton, Robert, Henderson, Liam, Gratton, Ruth, Clement, Keiran David, Chang, Kate Yu‐Ching, Mcnish, David, Mcintosh, Ryan, Milligan, William, Skelly, Brendan, Anderson‐Knight, Hannah, Lawther, Roger, Onimowo, Jemina, Shatkar, Veereanna, Tharmalingam, Shivanee, Woin, Evelina, Fautz, Tessa, Ziff, Oliver, Dindyal, Shiva, Arman, Sam, Talukder, Shagorika, Gadhvi, Vijay, Chew, Luen Shaun, Heath, Jonathan, Blencowe, Natalie, Hallam, Sally, Mannu, Gurdeep Singh, Zachariades, Dimitris‐Christo, Snaith, Ailsa Claire, Hettiarachchi, Thusitha Sampath, Nesaratnam, Arjun, Wheeler, Jame, McCullagh, Darragh, Clements, Joshua Michael, Khan, Ata, Koumpa, Foteini, Neophytou, Christina, Roth, Jessica, Soon, Wai Cheong, Deputy, Mohammed, Ahmed, Ahmed, Ashton, Annelisse, Vincent, Joe, Almy, Jack, Khan, Taufiq, 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Eleanor Franziska, Smart, Neil Jame, Warwick, Andrea Marie, Stasinou, Theodora, Daniels, Ian, Findlay‐Cooper, Kim, Mitrasinovic, Stefan, Ray, Swayamjyoti, Varcada, Massimo, D'Souza, Rovan, Omara, Sharif, Spurr, Matthew, Parkinson, Lucienne, Hanks, Anthony, Ma, Jennifer, Abington, Emily, Ramcharn, Meera, Williams, Gethin, Winstanley, Joseph, Kennedy, Ewan D., Yeung, Emily NW, Jones, Catrin, O'neill, Stephen, Lim, Shujing Jane, Liew, Ignatiu, Nair, Hari, Fairfield, Cameron, Oh, Julia, Koh, Samantha, Wilson, Andrew, Fairfield, Catherine, Anandkumar, Delran, Kirupagaran, Ashok, Jones, Timothy F, Torrance, Hew Dt, Fowler, Alexander J, Chandrakumar, Charmilie, Patel, Priyank, Ashraf, Syed Faaz, Lakhani, Sonam M., Mclean, Aaron Lawson, Basson, Sonia, Batt, Jeremy, Bowman, Catriona, Benons, Natasha, Mason, Clare, Harrison, Rebecca, Quayle, John, Barker, Tom, Summerour, Virginia, Harper, Edward, Smith, Caroline, Hampton, Matthew, Pitt, Sophie K, Ward, Alex E, O'Connor, Timothy, Heywood, Emily 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Tamsyn, Holton, Patrick, Livesey, Amy, Sinha, Yashashwi, Iqbal, Fahad Mujtaba, Bharj, Indervir Singh, Rotundo, Adriana, Jenvey, Cara, Slade, Robert, Golding, David, Haines, Samuel, Ne'ma Abdullah, Ali Adel, Tilston, Thomas W, Loughran, Dafydd, Donoghue, Danielle, Giacci, Lorenzo, Sherif, Mohamed Ashur, Harrison, Peter, Tang, Alethea, Kotecha, Deevia, Elshaer, Mohamed, Urbonas, Toma, Riaz, Amjid, Chapman, Annie, Acharya, Parisha, Shalhoub, Joseph, Grossart, Cathleen, McMorran, David, Mlotshwa, Makhosini, Hawkins, William, Loizides, Sofroni, Krishna, Kandaswamy, Orchard, Melanie, Ho, Chik Wai, Thomson, Peter, Khan, Shahab, Taylor, Fiona, Shukla, Jalak, Howie, Emma Elizabeth, Macdonald, Linda, Komolafe, Olusegun, Mcintyre, Neil, Cragg, Jame, Parker, Jody, Stewart, Duncan, Lintin, Luke, Tracy, Julia, Farooq, Tahir, Molina, George, Kaafarani, Haytham, Beyene, Robel, Sava, Jack, Scott, Mark, Swaroop, Mamta, Kennedy, Raelene, Azodo, Ijeoma A, Heffernan, Daithi, Chun, Tristen, Stephen, Andrew, Sion, Melanie, Weinstein, Michael S., Punja, Viren, Bugaev, Nikolay, Goodstein, Monica, Razmdjou, Shadi, Etchill, Eric, Puyana, Juan Carlo, Kesinger, Matthew, Napolitano, Lena, To, Kathleen, Hemmila, Mark, Todd, Oliver, Jenner, Edward, Hoogakker, Ellen, Grizhja, Besmir, Ymeri, Shpetim, Galiqi, Gezim, Klappenbach, Roberto, Antezana, Diego, Beleño, Alvaro Enrique Mendoza, Costa, Cecilia, Sanchez, Belen, Aviles, Susan, Fermani, Claudio Gabriel, Balmaceda, Rubén, Villalobos, Santiago, Carmona, Juan Manuel, Hamill, Daniel, Deutschmann, Peter, Sandler, Simone, Cox, Daniel, Nataraja, Ram, Sharpin, Claire, Ljuhar, Damir, Gray, Demi, Haines, Morgan, Iyer, Dush, Niranjan, Nithya, D'Amours, Scott, Ashtari, Morvarid, Franco, Helena, Karim, Sabbir, Aman, Nowrin F., Estee, Mahnuma Mahfuz, Salma, Umme, Razzaque, Joyeta, Kanta, Tasnia Hamid, Tori, Sayeeda Aktar, Alamin, Shadid, Roy, Swapnil, Al Amin, Shadid, Karim, Rezaul, Haque, Muhtarima, Faruq, Amreen, Iftekhar, Farhana, O'Shea, Margaret, Padmore, Greg, Jonnalagadda, Ramesh, Litvin, Andrey, Filatau, Aliaksandr, Paulouski, Dzmitry, Shubianok, Maryna, Shachykava, Tatsiana, Khokha, Dziani, Khokha, Vladimir, Djivoh, Fernande, Dossou, Franci, Seto, Djifid Morel, Gbessi, Dansou Gaspard, Noukpozounkou, Bruno, Keke, Kpèmahouton René, Hodonou, Fred, Ahounou, Ernest Yemalin Stephane, Alihonou, Thierry, Dénakpo, Max, Ahlonsou, Germain, Bedada, Alemayehu Ginbo, Nsengiyumva, Carlo, Kwizera, Sandrine, Barendegere, Venerand, Choi, Philip, Jamal, Luai, Chen, Tzu‐Ling, Yip, Chingwan, Zapata, Felipe, Lanau, Maria Isabel Villega, Restrepo, Ivan Mendoza, Giraldo, Ruben Santiago Restrepo, Youssef, Mohamed, Thabet, Waleed, Sanad, Aly, Zaki, Ahmed, Abdel‐Hameed, Noran, Mostafa, Mohamed, Omar, Muhammad Fathi Waleed, Ghanem, Ahmed, Denewar, Adel, Emara, Eman, Rashad, Eman, Sakr, Ahmad, Elashry, Rehab, Emile, Sameh, Khafagy, Toqa, Elhamouly, Sara, Elfarargy, Arwa, Mohamed, Amna Mamdouh, Nagy, Ghada Saied, Esam, Abeer, Elwy, Eman, Hammad, Aya, Khallaf, Salwa, Ibrahim, Eman, Saidbadr, Ahmed, Moustafa, Ahmed, Mohammed, Amany Eldosouky, Elgheriany, Mohammed, Abdelmageed, Eman, Al Raouf, Eman Abd, Elbanby, Esraa Samir, Elmasry, Maha, Farahat, Mahitab Morsy, Mansor, Eman Yahya, Hegazy, Eman Magdy, Gamal, Esraa, Gamal, Heba, Kandil, Hend, Abdelrouf, Doaa Maher, Moaty, Mohamed, Gamal, Dina, El‐Sagheer, Nada, Salah, Mohamed, Magdy, Salma, Salah, Asmaa, Essam, Ahmed, Ali, Ahmed, Badawy, Mahmoud, Ahmed, Sara, Mohamed, Mazed, Assal, Abdelrahman, Sleem, Mohamed, Ebidy, Mai, Elrazek, Aly Abd, Zahran, Diaaaldin, Adam, Nourhan, Nazir, Mohamed, Hassanein, Adel B, Ismail, Ahmed, Elsawy, Amira, Mamdouh, Rana, Mabrouk, Mohamed, Ahmed, Lopna Ahmed Mohamed, Alnaby, Mohamed Hassab, Magdy, Eman, Abd‐Elmawla, Manar, Fahim, Marwan, Mowafy, Bassant, Mahmoud, Moustafa Ibrahim, Allam, Meran, Alkelani, Muhammad, El Gendy, Noran Halim, Aboul‐Naga, Mariam Saad, El‐Din, Reham Alaa, Elgendy, Alyaa Halim, Ismail, Mohamed, Shalaby, Mahmoud, Elsharkawy, Aya Adel, Moghazy, Mahmoud Elsayed, Elbisomy, Khaled Hesham, Shakshouk, Hend Adel Gawad, Hamed, Mohamed Fouad, Ebidy, Mai Mohamed, Ahmed, Hayam, Adel, Israa, Omar, Mohammad Elsayed, Ibrahim, Mohamed, Ghoneim, Omar, Hesham, Omar, Gamal, Shimaa, Hilal, Karim, Arafa, Omar, Awad, Sawsan Adel, Salem, Menatalla, Elsherif, Fawzia Abdellatif, Elsabbagh, Nourhan, Aboelsoud, Moustafa R., Rida, Ahmed Hossam Eldin Fouad, Hossameldin, Amr, Hany, Ethar, Asar, Yomna Hosny, Anwar, Nourhan, Gadelkarim, Mohamed, Abdelhady, Samar, Morshedy, Eman Mohamed, Saad, Reham, Soliman, Nourhan, Salama, Mahmoud, Ezzat, Eslam, Mohamed, Arwa, Ibrahim, Arwa, Fergany, Alaa, Mohammed, Sara, Reda, Aya, Allam, Yomna, Saad, Hanan Adel, Abdelfatah, Afnan, Fathy, Aya Mohamed, El‐Sehily, Ahmed, Kasem, Esraa Abdalmageed, Hassan, Ahmed Tarek Abdelbaset, Mohammed, Ahmed Rabeih, Saad, Abdalla Gamal, Ibrahim, Arij, Hassaan, Amr, Mohammed, Mohammed Mustafa, Elhoseny, Ghada, Magdy, Mohamed, Elkhalek, Esraa Abd, Zakaria, Yehia, Ezzat, Tarek, El Dahab, Ali Abo, Kelany, Mohamed, Arafa, Sara, Hassan, Osama Mokhtar Mohamed, Badwi, Nermin Mohamed, Sleem, Ahmad Saber, Ahmed, Hussien, Abdelbadeai, Kholoud, Abdullah, Mohamed Abozed, Lokman, Muhammad Amsyar Auni, Bahar, Suraya, Abdelazeam, Anan Rady, Adelshone, Abdelrahman, Hasnan, Muhammad Bin, Zulkifli, Athirah, Kamarulzamil, Siti Nur Alia, Elhendawy, Abdelaziz, Latif, Aliang, Adnan, Ahmad Bin, Shaharuddin, Shahadatul, Majid, Aminah Hanum Haji Abdul, Al‐Marakby, Dina, Ismail, Mohamad Jeffrey Bin, Basir, Elissa Rifhan Mohd, Ali, Citra Dewi Mohd, Ata, Aya Yehia, Nasr, Maha, Rezq, Asmaa, Sheta, Ahmed, Tariq, Sherif, Sallam, Abd Elkhalek, Darwish, Abdelrhman KZ, Elmihy, Sohaila, Elhadry, Shady, Farag, Ahmed, Hajeh, Haidar, Abdelaal, Abdelaziz, Aglan, Amro, Zohair, Ahmed, Essam, Mahitab, Moussa, Omar, El‐Gizawy, Esraa, Samy, Mostafa, Ali, Safia, Elhalawany, Esraa, Ata, Ahmed, El Halawany, Mohamed, Nashat, Mohamed, Soliman, Samar, Elazab, Alaa, Samy, Mostada, Abdelaziz, Mohamed A, Ibrahim, Khaled, Ibrahim, Ahmed mohamed, Gado, Ammar, Eldeen, Esraa Alm, loaloa, Mohamed Reda, Abouzaid, Arwa, Eldin, Mostafa Ahmed Bahaa, Hashad, Eman, Sroor, Fathy, Gamil, Doaa, Abdulhakeem, Eman Mahmoud, Zakaria, Mahmoud, Mohamed, Fawzy, Abubakr, Marwan, Ali, Elsayed, Magdy, Hesham, Ramadan, Menna Tallah, Mohamed, Mohamed Abdelaty, Mansour, Salma, Amin, Hager Abdul Aziz, Mohamed, Ahmed Rabie, Saami, Mahmoud, Elsayed, Nada Ahmed Reda, Tarek, Adham, Mahmoud, Sabry Mohy Eldeen, El Sayed, Islam Magdy, Reda, Amira, Shawky, Martina Yusuf, Salem, Mohammed Mousa, El‐Din, Shahinaz Alaa, Soliman, Noha Abdullah, Talaat, Muhammed, Alaael‐Dein, Shahinaz, Elhusseiny, Ahmed Abd Elmoen, Abdullah, Noha, Elshaar, Mohammed, Ibraheem, Aya AbdelFatah, Abdulaziz, Hager, Ismail, Mohammed Kamal, Madkor, Mona Hamdy, Abdelaty, Mohamed, Abdel‐Kader, Sara Mahmoud, Salah, Osama Mohamed, Eldafrawy, Mahmoud, Eldeeb, Ahmed Zaki, Eid, Mostafa Mahmoud, Attia, Attia, Shwky, Ayman, Badenjki, Mohamed Adel, Soliman, Abdelrahman, Al Attar, Samaa Mahmoud, Sayed, Farrag, Sabour, Fahd Abdel, Azizeldine, Mohammed G., Shawqi, Muhammad, Hashim, Abdullah, Aamer, Ahmed, Abdelraouf, Ahmed Mahmoud, Abdelshakour, Mahmoud, Ibrahim, Amal, Mahmoud, Basma, Mahmoud, Mohamed Ali, Qenawy, Mostafa, Rashed, Ahmed M., Dahy, Ahmed, Sayed, Marwa, Shamsedine, Ahmed W., Mohamed, Bakeer, Hasan, Ahmad, Saad, Mahmoud M., Bassit, Khalil Abdul, El‐Latif, Nadia Khalid Abd, Elzahed, Nada, El Kashash, Ahmed, Bekhet, Nada Mohamed, Hafez, Sarah, Gad, Ahmed, Maher, Mahmoud Elkhadragy, Elsameea, Ahmed Abd, Hafez, Mohamed, Sabe, Ahmad, Ahmed, Ataa, Shahine, Ahmed, Dawood, Khaled, Gaafar, Shireen, Husseiny, Reem, Aboelmagd, Omnia, Soliman, Ahmed, Mesbah, Nourhan, Emadeldin, Hossam, Al Meligy, Amgad, Bekhet, Amira Hassan, Hasan, Doaa, Alhady, Khaled, Sabe, Ahmad Khaled, Elnajjar, Mahmoud A., Aboelella, Majed, Hamsho, Ward, Hassan, Ihab, Saad, Hala, Abdelazim, Galaleldin, Mahmoud, Hend, Wael, Noha, Kandil, Ahmedali M, Magdy, Ahmed, Elkholy, Shimaa Said, Adel, Badr Eldin, Dabbour, Kareem, Elsherbiney, Saged, Mattar, Omar, Abdrabou, Abdulshafi Khaled, Aly, Mohammed Yahia Mohamed, Geuoshy, Abdelrahman, Elnagar, Ahmedglal, Ahmed, Saraibrahim, Abdelmotaleb, Ibrahem, Saleh, Amr Ahmed, Saeed, Manar, Mahmoud, Shady, Tawfik, Badreldin Adel, Ismail, Samar Adel, Zakaria, Esraay, Gad, Mariam O., Elhelbawy, Mohamed Salah, Bassem, Monica, Maraie, Noha, Elhadary, Nourhan Medhat, Semeda, Nourhan, Mohamed, Shaza Rabie, Bakry, Hesham Mohammed, Essam, AA, Tarek, Dina, Ashour, Khlood, Elhadad, Alaa, Abdel‐Aty, Abdulrahman, Rakha, Ibrahim, Matter, Sara Mamdouh, Abdelhamed, Rasha, Abdelkader, Omar, Hassaan, Ayat, Soliman, Yasmin, Mohamed, Amna, Farouk, Sara Amr Mohamed, Ibrahim, Eman Mohamed, El‐Taher, Esraa, Mostafa, Merna, Badr, Mohamed Fawzy Mahrou, Elsemelawy, Rofida, El‐Sawy, Aya, Bakr, Ahmad, Al Rafati, Ahmad Abdel Razaq, Saar, Sten, Reinsoo, Arvo, Seyoum, Nebyou, Worku, Tewodro, Fitsum, Agazi, Tolonen, Matti, Parmentier, Benoît, Dardenne, Sabrina, Robert, Elsa, Maillot, Betty, Courboin, Etienne, Hascoet, Juliette, Kaci, Amir Ait, Prudhomme, Thoma, Ballouhey, Quentin, Grosos, Céline, Fourcade, Laurent, Cecilia, Tolg, Jean‐Francois, Colombani, Helene, Francois‐Coridon, Delforge, Xavier, Haraux, Elodie, Dousset, Bertrand, Schiavone, Roberto, Gaujoux, Sebastien, Marret, Jean‐Baptiste, Haffreingue, Aurore, Rod, Julien, Renaux‐Petel, Mariette, Lecompte, Jean‐Françoi, Bréaud, Jean, Gastaldi, Pauline, Taieb, Chouikh, Claire, Raquillet, Anis, Echaieb, Bustangi, Nasir, Lopez, Manuel, Grella, Maria Giovanna, Mariani, Aurora, Schmitt, Françoise, Broch, Aline, Bandoh, Dickson, Kyereh, Martin, Asumah, Hamza, Appiah, Eric Kofi, Wondoh, Paul, Gyedu, Adam, Dally, Charle, Agbedinu, Kwabena, Amoah, Michael, Yifieyeh, Abiboye, Amoako‐Boateng, Mabel, Dayie, Makafui, Hagan, Richmond, Debrah, Sam, Ohene‐Yeboah, Micheal, Clegg‐Lampety, Joe‐Nat, Etwire, Victor, Dakubo, Jonathan, Essoun, Samuel, Bonney, William, Glover‐Addy, Hope, Osei‐Nketiah, Samuel, Amoako, Joachim, Adu‐Aryee, Niiarmah, Appeadu‐Mensah, William, Bediako‐Bowan, Antoinette, Dedey, Florence, Ekow, Mattew, Akatibo, Emmanuel, Yakubu, Musah, Kordorwu, Hope Edem Kofi, Asare‐Bediako, Kwasi, Tackie, Enoch, Aaniana, Kenneth, Acquah, Emmanuel, Opoku‐Agyeman, Richard, Avoka, Anthony, Kusi, Kwasi, Maison, Kwame, Gyamfi, Frank Enoch, Barnabas, Gandau Naa, Abdul‐Latif, Saiba, Amoako, Philip Taah, Davor, Anthony, Dassah, Victor, Dagoe, Enoch, Kwakyeafriyie, Prince, Akoto, Elliot, Ackom, Eric, Mensah, Ekow, Atkins, Ebenezer Takyi, Coompson, Christian Lari, Ivros, Nikolao, Ferousis, Christoforo, Kalles, Vasileio, Kyriazanos, Ioanni, Barkolias, Christo, Tselos, Angelo, Tzikos, Georgio, Voulgaris, Evangelo, Bamicha, Athanasia, Stefanopoulos, Anastasio, Patoulias, Ioanni, Sfougaris, Dimitrio, Valioulis, Ioanni, Balalis, Dimitrio, Korkolis, Dimitrio, Manatakis, Dimitrios K, Kyrou, Georgio, Karabelias, Georgio, Papaskarlatos, Iason‐Antonio, Konstantina, Kolonia, Zampitis, Nikolao, Papailia, Aspasia, Theodosopoulos, Theodosio, Gkiokas, Georgio, Mitroudi, Magdalini, Panteli, Christina, Feidantsis, Thoma, Farmakis, Konstantino, Kyziridis, Dimitrio, Ioannidis, Oresti, Parpoudi, Styliani, Parasyris, Stavro, Margaritis, Michail, Aguilera‐Arevalo, Maria‐Lorena, Coyoy‐Gaitan, Otto, Rosales, Javier, Tale, Lui, Rodriguez, Servio Tulio Torre, Galvez, Carlos Paz, Cruz, Danilo Herrera, Rosenberg, Guillermo Sanchez, Matheu, Alejandro, Cohen, David Monterroso, Paul, Marie, Charles, Angeline, Lam, Justin Chak Yiu, Yeung, Man Hon Andrew, Fok, Chi Ying Jacquelyn, Li, Ka Hin Gabriel, Lai, Anthony Chuk‐Him, Cheung, Yuk Hong Eric, Wong, Hong Yee, Leung, Ka Wai, Lee, Tien Seng Bryan, Lam, Wai Him, Dao, Weihei, Kwok, Stephanie Hiu‐wai, Chan, Tsz‐Yan Katie, Ng, Yung Kok, Mak, TWC, Foo, Chi Chung, Yang, Jame, Bhatnagar, Ankur, Upadhyaya, Vijaid, Muddebihal, Uday, Dar, Wasim, Janardha, KC, Aruldas, Neerav, Adella, Fidelis Jacklyn, Rulie, Anthonius Santoso, Iskandar, Ferdy, Setiawan, Jonny, Evajelista, Cicilia Viany, Natalie, Hani, Suyadi, Arlindawati, Gunawan, Rudy, Karismaningtyas, Herlin, Mata, Lusi Padma Sulistianingsih, Andika, Ferry Fitriya Ayu, Hasanah, Afifatun, Widiastini, T Ariani, Purwaningsih, Nurlaila Ayu, Mukin, Annisa Dewi Fitriana, Rahmah, Dina Faizatur, Nurqistan, Hazmi Dwinanda, Arsyad, Hasbi Maulana, Adhitama, Novia, Jeo, Wifanto Saditya, Sutandi, Nathania, Clarissa, Audrey, Gultom, Phebe Anggita, Billy, Matthew, Haloho, Andrea, Johanna, Nadya, Lee, Felix, Dorani, Radin Mohd Nurrahman Radin, Glynn, Martha, Alherz, Mohammad, Goh, Wennweoi, Shiwani, Haaris A., Sproule, Lorraine, Conlon, Kevin C., Bala, Miklosh, Kedar, Asaf, Bianco, Federica, Steccanella, Francesca, Gallo, Gaetano, Trompetto, Mario, Clerico, Giuseppe, Papandrea, Matteo, Sammarco, Giuseppe, Sacco, Rosario, Giavarini, Luisa, Giglio, Mariano Cesare, Bucci, Luigi, Pagano, Gianluca, Sollazzo, Viviana, Peltrini, Roberto, Luglio, Gaetano, Birindelli, Arianna, Mingrone, Pietro, Selvaggi, Francesco, Selvaggi, Lucio, Pellino, Gianluca, Di Martino, Natale, Curletti, Gianluca, Aonzo, Paolo, Galleano, Raffaele, Berti, Stefano, Francone, Elisa, Boni, Silvia, Lorenzon, Laura, lo Conte, Annalisa, Balducci, Genoveffa, Confalonieri, Gianmaria, Pesenti, Giovanni, Gavagna, Laura, Vasquez, Giorgio, Targa, Simone, Occhionorelli, Savino, Andreotti, Dario, Armellini, Andrea, Chiesa, Deborah, Aquilino, Fabrizio, Chetta, Nicola, Picciariello, Arcangelo, Abdelkhalek, Mohamed, Belli, Andrea, De Franciscis, Silvia, Bigaran, Annamaria, Favero, Alessandro, Basso, Stefano M.M, Salusso, Paola, Perino, Martina, Mochet, Sylvie, Sasia, Diego, Riente, Francesco, Migliore, Marco, Basilicò, Silvia, Corbellini, Carlo, Lazzari, Veronica, Angelieri, Daniele, Coletta, Diego, Falaschi, Federica, Catani, Marco, Reali, Claudia, Malavenda, Mariastella, Del Basso, Celeste, Ribaldi, Sergio, Coletti, Massimo, Natili, Andrea, Depalma, Norma, Iannone, Immacolata, Antoniozzi, Angelo, Rossi, Davide, Gui, Daniele, Perrotta, Gerardo, Ripa, Matteo, Giardino, Francesco Ruben, Foco, Maurizio, Vicario, Erika, Nita, Gabriela Elisa, Leone, Nicoletta, Simioni, Andrea, De Boni, Davide, Pasquali, Sandro, Goldin, Elena, Vendramin, Elena, Ciccioli, Eleonora, Tedeschi, Umberto, Violi, Paola, Campagnaro, Tommaso, Conci, Simone, Lazzari, Giovanni, Iacono, Calogero, Gulielmi, Alfredo, Manfreda, Serena, Rinaldi, Anna, Ringressi, Maria Novella, Brunoni, Beatrice, Salamone, Giuseppe, Mangiapane, Mirko, De Marco, Paolino, La Brocca, Antonella, Tutino, Roberta, Silvestri, Vania, Licari, Leo, Fontana, Tommaso, Falco, Nicolò, Cocorullo, Gianfranco, Shalaby, Mostafa, Sileri, Pierpaolo, Arcudi, Claudio, Bsisu, Isam, Aljboor, Khaled, Abusalem, Lana, Alnusairat, Aseel, Qaissieh, Ahmad, Al‐Dakka, Emad, Ababneh, Ali, Halhouli, Oday, Yusufali, Taha, Mohammed, Hussein, Lando, Justu, Parker, Robert, Ndegwa, Wairimu, Gribauskaite, Jolanta, Kuliavas, Justa, Dulskas, Audriu, Samalavicius, Narimantas E., Jasaitis, Kristijona, Parseliunas, Audriu, Nevieraite, Viktorija, Slapelyte, Evelina, Dainius, Edvina, Subocius, Andreju, Venclauskas, Lina, Gulbinas, Antana, Kasputyte, Simona, Mikuckyte, Deimante, Kiudelis, Mindauga, Jankus, Toma, Petrikenas, Stepona, Pažuskis, Mata, Urniežius, Zigmanta, Vilčinskas, Manta, Banaitis, Vincas Jona, Gaižauskas, Vytauta, Grisin, Edvard, Mazrimas, Povila, Drungilas, Manta, Lagunavicius, Karoli, Lipnickas, Vytauta, Majauskyté, Dovilè, Abaliksta, Toma, Uščinas, Laimona, Simutis, Gintara, Ladukas, Adoma, Danys, Donata, Sruogiene, Elena Zdanyte, Višinskas, Petra, Žilinskienė, Reda, Dragatas, Deivida, Burmistrovas, Andriu, Tverskis, Zygimanta, Vaicius, Artura, Mazelyte, Ruta, Zadoroznas, Antana, Žiubrytė, Greta, Rahantasoa, Finaritra Casimir Fleur Prudence, Samison, Luc Hervé, Rasoaherinomenjanahary, Fanjandrainy, Tolotra, Todisoa Emmanuella Christina, Mukuzunga, Corneliu, Kwatiwani, Chimwemwe, Msiska, Nelson, Chai, Feng Yih, Asilah, Siti Mohd Desa, Syibrah, Khuzaimah Zahid, Chin, Pui Xin, Riswan, Nur Zulaika, Chong, Hoong‐Yin, Aziz, Nora Abdul, Poh, Keat‐Seong, Chai, Chu‐Ann, Kumar, Sandip, Taher, Mustafa Mohammed, Aziz, Dayang Nita Abdul, Julaihi, Rokayah, Jethwani, Durvesh Lacthman, Yahaya, Muhammad Taqiyuddin, Mathew, Susan Wndy, Chung, Kuet Jun, Nirumal, Milaksh Kumar, Tze, R. Goh Ern, Ali, Syed Abdul Wahhab Eusoffee Wan, Gan, Yiing Yee, Ting, Jesse Ron Swire, Sii, Samuel S. Y., Koay, Kean Leong, Tan, Yi Koon, Cheah, Alvin Ee Zhiun, Wong, Chui Yee, Nur'Azmah Tuan Mat, Tuan, Chow, Crystal Yern Nee, Har, Prisca A.L., Der, Yishan, Henry, Fitjerald, Low, Xinwei, Neo, Ya Theng, Heng, Hian Ee, Kong, Shu Ning, Gan, Cheewei, Mok, Yi Ting, Tan, Yee Wen, Palayan, Kandasami, Tata, Mahadevan Deva, Cheong, Yih Jeng, Gunaseelan, Kuhaendran, 'Ain Wan Mohd Nasir, Wan Nurul, Yoganathan, Pigeneswaren, Lee, Eu Xian, Saw, Jian Er, Yeang, Li Jing, Koh, Pei Ying, Lim, Shyang Yee, Teo, Shuang Yi, Grech, Nicole, Magri, Daniela, Cassar, Kristina, Mizzi, Christine, Falzon, Malcolm, Shaikh, Nihaal, Scicluna, Ruth, Zammit, Stefan, Mizzi, Sean, Brincat, Svetlana Dori, Tembo, Thelma, Le, Vu Thanh Hien, Grima, Tara, Sammut, Keith, Carabott, Kurt, Zarb, Ciskje, Navarro, Andre, Dimech, Thea, Camilleri, Georgette Marie, Bertuello, Isaac, Dalli, Jeffrey, Bonavia, Karl, Corro‐Diaz, Samantha, Manriquez‐Reyes, Marisol, Abdelhamid, Amina, Hrora, Abdelmalek, Benammi, Sarah, Bachri, Houda, Abbouch, Meryem, Boukhal, Khaoula, Bennai, Redouane Mammar, Belkouchi, Abdelkader, Jabal, Mohamed Sobhi, Benyaiche, Chaymae, Vermaas, Maarten, Duinhouwer, Lucia, Pastora, Javier, Wood, Greta, Merlo, Maria Soledad, Ajao, Akinlabi, Ayandipo, Omobolaji, Lawal, Taiwo, Abdurrazzaaq, Abdussemiu, Alada, Muslimat, Nasir, Abdulrasheed, Habeeb, Olufemi, Mendel, Henry, Bello, Bashir, Muktar, Umar, Olajide, Thomas Olagboyega, Oshati, Oyindamola, Ihediwa, George, Adenekan, Babajide, Nwinee, Victor, Lawal, Abdulrazzaq, Bode, Chri, Olugbemi, Mojolaoluwa, Odutola, Oluwatomi, Adebola, Oluwaseyi, Onuoha, Clement, Balogun, Fatai, Ajai, Olalekan, Njokanma, Iloba, Kache, Stephen, Ajah, Jonathan, Makama, Jerry, Adamu, Ahmed, Baba, Suleiman, Aliyu, Mohammad, Aliyu, Shamsudeen, Ukwenya, Yahaya, Aliyu, Halima, Sholadoye, Tunde, Daniyan, Muhammad, Ogunsua, Oluseyi, Sheshe, Abdurrahaman, Mshelbwala, Philip, Samson, Garba, Timothy, Oyediran Kehinde, Samuel, Sani Ali, Ajiboye, Anthony, Amole, Isaac, Abiola, Olajide, Olaolorun, Akin, Veen, Torhild, Kanani, Arezo, Styles, Kristian, Herikstad, Ragnar, Larsen, Johannes Wiik, Søreide, Jon Arne, Jensen, Elisabeth, Gran, Mad, Aahlin, Eirik Kju, Gaarder, Tina, Monrad‐Hansen, Peter Wiel, Næss, Pål Aksel, Lauzikas, Giedriu, Wiborg, Joachim, Holte, Silje, Augestad, Knut Magne, Banipal, Gurpreet Singh, Moe, Thomas Teten, Schultz, Johannes Kurt, Al‐taher, Taher, Hamdan, Ayah, Salman, Ayman, Saadeh, Rana, Musleh, Aseel, Jaradat, Dana, Abushamleh, Soha, Hanoun, Sakhaa, Qumbos, Amjad Abu, Hamarshi, Aseel, Taher, Ayman And, Qawasmi, Israa, Qurie, Khalid, Altarayra, Marwa, Ghannam, Mohammad, Shaheen, Alaa, Herebat, Azher, Abdelhaq, Aram, Shalabi, Ahmad, Abu‐toyour, Maram, Asi, Fatema, Shamasneh, Ala, Atiyeh, Anwar, Mustafa, Mousa, Zaa'treh, Rula, Dabboor, Majd, Alaloul, Ena, Baraka, Heba, Meqbil, Jehad, Al‐Buhaisi, Alaa, Elshami, Mohamedraed, Afana, Samah, Jaber, Sahar, Alyacoubi, Said, Abuowda, Yousef, Idress, Tasneem, Abuqwaider, Eman, Al‐saqqa, Sara, Bowabsak, Alaa, El Jamassi, Alaa, Hasanain, Doaa, Al‐farram, Hadeel, Salah, Maram, Firwana, Aya, Hamdan, Marwa, Awad, Israa, Ashour, Ahmad, Al Barrawi, Fayez Elian, Al‐khatib, Ahmed, Al‐faqawi, Maha, Fares, Mohamed, Elmashala, Amjad, Adawi, Mohammad, Adawi, Ihdaa, Khreishi, Reem, Khreishi, Rose, ashour, Ahmad, Ghaben, Ahed, Nadeem, Najwa, Saqlain, Muhammad, Abbasy, Jibran, Alvi, Abdul Rehman, Shahzad, Noman, Butt, Muhammad Talha, Asaat ul Razi, Syed, Ahmed, Asdaq, Niazi, Ali Khan, Raza, Ibrahim, Baluch, Fatima, Raza, Ahmed, Bani‐Sadar, Ahmad, Adil, Muhammad, Raza, Awai, Javaid, Mahnoor, Waqar, Muhammad, Khan, Maryam Ali, Arshad, Mohammad Mohsin, Amjad, Mohammadasim, Cardozo, Jorge Torre, Roche, Marcelo O'Higgin, Servin, Gustavo Rodolfo Pertersen, Lopez, Larissa Ines Páez, Cardozo, Ramón Augusto Melo, Espinoza, Fernando, Rojas, Angel David Pérez, Sanchez, Diana, Samaniego, Camila Sanchez, Torres, Shalon Guevara, Calua, Alexander Canta, Razuri, Cesar, Ortiz, Nadia, Rodriguez, Xianelle, Carrasco, Nahilia, Saravia, Fridiz, Miyasato, Hector Shibao, Valcarcel‐Saldaña, María, Bermúdez, Ysabel Esthefany Alejo, Carpio, Juan, Panez, Walter Ruiz, Orbegozo, Pedro Angel Toribio, Dueñas, Carolina Guzmán, Espinoza, Kevin Turpo, Barrantes, Ana Maria Sandoval, Bravo, Jorge Armando Chungui, Fuentes‐Rivera, Lorena, Fernández, Carmen, Málaga, Bárbara, Ye, Joselyn, Velasquez, Ricardo, Salcedo, Jannin, Contreras‐Vergara, Ana Lucia, Mejia, Angelica Genoveva Vergara, Montejo, Maria Soledad Gonzale, Salas, Marilia Del Carmen Escalante, Ticona, Willy Alcca, Vargas, Marvin, Sila, George Christian Manrique, Mas, Robinson, Pilar Paucar, Arazzelly, Velásquez, Armando José Román, Robledo‐Rabanal, Alina, Solis, Ludwing Alexander Zeta, Espinoza, Kenny Turpo, Hamaguchi, José Luis Hamasaki, Farfan, Erick Samuel Florez, Barrientos, Linda Alvi Madrid, Matta, Juan Jaime Herrera, Mora, John Jemuel V., Redota, Menold Archee P., Roxas, Manuel Francisco, Maño, Maria Jesusa B., Parreno‐Sacdalan, Marie Dione, Almanon, Christel Leanne, Walędziak, Maciej, Roszkowski, Rafał, Janik, Michał, Lasek, Anna, Radkowiak, Dorota, Rubinkiewicz, Mateusz, Fernandes, Cristina, Muntean, Liviu, Popa, Mariuca, Mircea, Hogea, Diaconescu, Bogdan, Bratu, Matei Razvan, Negoi, Ionut, Ciubotaru, Cezar, Uzabumwana, Norbert, Duhoranenayo, Dieudonne, Idris, Faisal, Alghamdi, Mohammed Saleh A., Maghrabi, Ashraf, Alkaaki, Aroub, Turkustani, Sondo, Khalifah, Eyad, Albiety, Adel, Sahel, Sarah, Alshareef, Reham, Alzahrani, Mohammed Najjar Ahmed, Alghamdi, Ahmed, Alhazmi, Wedyan, Al Saied, Ghiath, Alamoudi, Mohammed, Riaz, Muhammed Masood, Alhassan, Basmah, Altamimi, Abdullah, Alyahya, Reem, Al Subaie, Norah, Al Bastawis, Fatema, Khan, Roaa, Radojkovic, Milan, Jeremic, Ljiljana, Nestorovic, Milica, Law, Jia Hao, Tan, Keith Say Kwang, Tan, Ryan Choon Kiat, Tan, Joel Kin, Joel, Lau Wen Liang, Chan, Xue Wei, Leong, Faith Qi Hui, Chong, Choon Seng, Koh, Sharon, Lee, Kai Yin, Lee, Kuok Chung, Pluke, Kent, Dedekind, Britta, Nashidengo, Puyearashid, Hampton, Mark Ian, Joosten, Johanna, Sobnach, Sanju, Roodt, Liana, Sander, Anthony, Pape, Jame, Maistry, Niveshni, Ndwambi, Phumudzo, Kinandu, Kamau, Du Toit, Frederick, Ellison, Quinn, Burger, Sule, Grobler, DC, Khulu, Lawrence Bongani, Leusink, Astrid, Kariem, Nazmie, Gouws, Juan, Chu, Kathryn, Bougard, Heather, Noor, Fazlin, Dell, Angela, Van Straten, Stephanie, Khamajeet, Arvin, Tshisola, Serge Kapenda, Kabongo, Kalangu, Moodley, Yoshan, Anderson, Frank, Madiba, Thandinkosi, Plooy, Flip, Hartford, Leila, Chilton, Gareth, Karjiker, Parveen, Mabitsela, Matlou Ernest, Ndlovu, Sibongile Ruth, Badicel, Maria, Jaich, Robert, Ruiz‐Tovar, Jaime, Garcia‐Florez, Lui, Otero‐Díez, Jorge L., Pérez, Virginia Ramo, Suárez, Nuria Aguado, García, Javier Minguez, Moreno, Sara Corral, Collado, Maria Vicenta, Carneros, Virginia Jiménez, Septiem, Javier García, Gonzalez, Mariana, Picardo, Antonio, Esteban, Enrique, Ferrero, Esther, Espin‐Basany, Eloy, Blanco‐Colino, Ruth, Andriola, Valeria, Contreras, Elisa, Bernardo, Carmen García, Sanz, Sandra, León, Alberto Miyar, Dorismé, Asnel, Rodicio, Joselui, Suarez, Aida, Stuva, Jessica, Vico, Tamara Diaz, Fernandez‐Vega, Laura, Soldevila‐Verdeguer, Carla, Sena‐Ruiz, Fatima, Pujol‐Cano, Natalia, Diaz‐Jover, Paula, Garcia‐Perez, José Maria, Segura‐Sampedro, Juan Jose, Pineño‐Flores, Cristina, Ambrona‐Zafra, David, Craus‐Miguel, Andrea, Jimenez‐Morillas, Patricia, Mazzella, Angela, Jayathilake, A.B, Thalgaspitiya, S.P.B, Wijayarathna, L.S., Wimalge, P.M.S.N., Sanni, Hakeem Ayomi, Okenabirhie, Ogheneochuko, Homeida, Anmar, Younis, Abobaker, Omer, Omer Abdelbagi, Abdulaziz, Mustafa, Mussad, Ali, Adam, Ali, Sokratous, Aresti, Breistrand, Michaela, Sigurdadottir, Johanna, Nikberg, Maziar, Chabok, Abba, Elbe, Peter, Saraste, Deborah, Rutkowski, Wiktor, Forlin, Louise, Niska, Karoliina, Oswald, Denni, Peros, Georgio, Bluelle, Rafael, Reinisch, Katharina, Frey, Daniel, Palma, Adrian, Zumbühl, Luciu, Werder, Gabriela, Mahanty, Silke, Widmer, Lukas Werner, Müller, Julia, Gübeli, Alissa, Zuk, Grzegorz, Gulcicek, Osman Bilgin, Vartanoglu, Talar, Kose, Emin, Karahan, Servet Rustu, Aydin, Mehmet Can, Sahbaz, Nuri Alper, Halicioglu, Ilkay, Alis, Halil, Sapci, Ipek, Adıyaman, Can, Pektaş, Ahmet Murat, Cengiz, Turgut Bora, Tansoker, Ilkan, Işler, Vedatcan, Cevik, Muazzez, Mutlu, Deniz, Ozben, Volkan, Ozmen, Berk Bari, Bayram, Sefa, Yolcu, Sinem, Kobal, Berna Buse, Toto, Ömer Faruk, Çakaloğlu, Haluk Cem, Karabulut, Kagan, Mutlu, Vahit, Celik, Saban, Semiz, Anil, Bodur, Selim, Gül, Enisburak, Murutoglu, Busra, Yildirim, Reyyan, Baki, Bahadir Emre, Arslan, Ekin, Ulusahin, Mehmet, Guner, Ali, Walker, Nathan, Shrimanker, Nikhita, Cole, Simon, Breslin, Ryan, Srinivasan, Ravi, Hunter, Kristina, Al‐Bahrani, Ahmed, Mairs, Nora Grace, Rocke, Alistair, Dick, Lachlan, Qureshi, Mobeen, Chowdhury, Debkumar, Wright, Naomi, Skerritt, Clare, Kufeji, Dorothy, Ho, Adrienne, Dissanayake, Tharindra, Tennakoon, Athula, Ali, Wadah, Tan, Charlene, O'Neill, Stephen, Knight, Stephen, Nassif, Dima, Sharma, Abhishek, White, Rebecca, Mehdi, Aia, Post, Nathan, Kalakouti, Eliana, Dashnyam, Enkhbat, Stourton, Frederick, Mykoniatis, Ioanni, Wong, Francisca, Gupta, Ashish, Shatkar, Veeranna, Kadiwar, Suraj, Smedley, Alexander, Wakefield, Rebecca, Herrod, Philip, Blackwell, Jame, Cohen, Fraser, Bandi, Ashwath, Bond‐Smith, Gile, Farhangmehr, Neda, Perenyei, Miklo, Ireland, Philip, Bowling, Kirk, Bunting, David, Longstaff, Lydia, Keogh, Kenneth, Jeon, Hyunjin, Iqbal, Muhammad Rafaih, Khosla, Shivun, Jeffery, Anna, Perera, Jame, Alhammali, Tariq, Oram, Shaun, Kidd, Thoma, Cullen, Fraser, Owen, Christopher, Wilson, Michael, Chiu, Seehui, Sarafilovic, Hannah, Ploski, Jennifer, Evans, Elizabeth, Abbas, Athar, Kamya, Sylvia, Ishak, Norzawani, Bisset, Carly, Andress, Cedar, Chin, Ye Ru, Patel, Priya, Evans, David, Haslegrave, Aidan, Boggon, Adam, Laurie, Kirsten, Mann, Thoma, Mansuri, Anahita, Davies, Rachel, Shahbaz, Aized Raza, Eng, Calvin, Din, Farhat, L'Heveder, Ariadne, Park, Esther H.G., Ravishankar, Ramanish, McIntosh, Kirsten, Yau, Jih Dar, Chan, Luke, McGarvie, Susan, Tang, Lingshan, Lim, Hui, Yap, Suhhuey, Park, Jay, Ng, Zhan Herr, Mirza, Shahrukh, Ang, Yun Lin, Walls, Luke, Roy, Chloe, Paterson‐Brown, Simon, Mclean, Kenneth, D'Souza, Michelle S, Pronin, Savva, Henshall, David Ewart, Ter, Eunice Zuling, English, William, Morgan, Catrin, Townsend, Dominic, Maciejec, Laura, Mahdi, Shareef, Akpenyi, Onyinye, Hall, Elisabeth, Caydiid, Hanaan, Rob, Zakaria, Abbott, Tom, Torrance, Hew D, Johnston, Robin, Gani, Mohammed Akil, Rajmohan, Shivanchan, Majid, Kiran, Smith, Christopher, Palliyil, Madanmohan, Patel, Sanjay, Nicholson, Luke, Harvey, Neil, Shillito, Sam, Kershaw, Suzanne, Bamford, Rebecca, Orton, Peter, Reunis, Elke, Jama, Guled M., Dhillon, Dharminder, Patel, Khyati, Nanthakumaran, Shayanthan, Heard, Rachel, Chen, Kar Yan, Barmayehvar, Behrad, Datta, Uttaran, Kamarajah, Sivesh K, Tani, Sobhana Iftekhar, Donnelly, Philippa, Walker, Michael, Blacker, Sarah, Kaul, Anil, Paramasivan, Arjun, Farag, Sameh, Nessa, Ashrafun, Awadallah, Salwa, Lim, Jieqi, Ng, James Chean Khun, Kiran, Ravi P., Murray, Alice, Dasari, Mohini, Puyana, Juan, Haddad, Nadeem, Zielinski, Martin, Choudhry, Asad, Caliman, Celeste, Beamon, Mieshia, Duane, Therese, Myers, Jonathan, Deal, Rebecca, Makupe, Alex, Musowoya, Joseph, Van Der Naald, Niel, Kumwenda, Dayson, Reece‐Smith, Alex, Otten, Kar, Verbeek, Anna, Prins, Marloe, Suarez, Alibeth Andres Baquero, Deane, Chelsea, Dijan, Emilio, Elfiky, Mahmoud, Koskenvuo, Laura, Thollot, Aurore, Limoges, Bernard, Capito, Carmen, Alexandre, Challine, Kotobi, Henri, Leroux, Julien, Pinnagoda, Kalitha, Henric, Nicola, Azzis, Olivier, Rosello, Olivier, Francois, Poddevin, Etienne, Sara, Buisson, Philippe, Hmila, Sophian, Clegg‐Lamptey, Joe‐Nat, Imoro, Osman, Abem, Owusu Emmanuel, Papageorgiou, Dimitrio, Soulou, Vasiliki, Asturias, Sabrina, Peña, Lenin, O'Connor, Donal B, Luc, Alberto Reali, Russo, Alfio Alessandro, Ruzzenente, Andrea, Taddei, Antonio, Cona, Camilla, Bottini, Corrado, Pascale, Giovanni, Rotunno, Giuseppe, Solaini, Leonardo, Pascale, Marco Maria, Notarnicola, Margherita, Corbellino, Mario, Sacco, Michele, Ubiali, Paolo, Cautiero, Roberto, Bocchetti, Tommaso, Muzio, Elena, Guglielmo, Vania, Morandi, Eugenio, Mao, Patrizio, De Luca, Emilia, Ali, Farah Mahmoud, Žilinskas, Justa, Kondrotas, Pauliu, Baltrunas, Roberta, Kutkevicius, Juoza, Ignatavicius, Povila, Tan, Choy Ling, Siaw, Jia Yng, Yam, Sir Young, Wilson, Ling, Aziz, Mohamed Rezal Abdul, Bondin, John, Zorrilla, Carmina Diaz, Majbar, Ana, Sale, Danjuma, Abdullahi, Lawal, Osagie, Olabisi, Faboya, Omolara, Fatuga, Adedeji, Taiwo, Agboola, Nwabuoku, Emeka, Bliksøen, Marte, Khan, Zain Ali, Coronel, Jazmin, Miranda, Cesar, Vasquez, Idelso, Helguero‐Santin, Luis M., Rickard, Jennifer, Adedeji, Adesina, Alqahtani, Saleh, Rath, Max, Van Niekerk, Michael, Koto, Modise Zacharia, Matos‐Puig, Roel, Israelsson, Leif, Schuetz, Tobia, Yuksek, Mahmut Arif, Mericliler, Meric, Uluşahin, Mehmet, Yong, Guo Liang, Whitehurst, Katharine, Redgrave, Natalie, Musyoka, Caroluce K, Olivier, Jame, Lee, Kathryn, Cox, Michael, Farhan‐Alanie, Muhamed M H, Callan, Rory, Chibuye, Chali, Ali, Tebian Hassanein Ahmed, Rekhis, Syrine, Rommaneh, Muna, Sam, Zi Hao, Chen, Jacky Hong Chieh, Roi, Dylan, Pugliesi, Thays Brunelli, Pardo, Gabriel, Blanco, Ruth, Escobar, Eugenio Grasset, GlobSurg Collaboration, Group, and Sileri, P

Subjects
Male, modelos logísticos, medicine.medical_treatment, humanos, surgial care, Colorectal Neoplasm, países desarrollados, Logistic regression, outcomes, Global Health, urgencias médicas, 0302 clinical medicine, países en desarrollo, Surgical, estudios prospectivos, Colostomy, 80 and over, globalsurg, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Multivariate Analysi, mediana edad, Cancer, Aged, 80 and over, Emergencie, anciano, Anastomosis, colorectal resection, colostomy, Anastomosis, Surgical, General Medicine, Middle Aged, adulto, colostomy, colorectal cancer, human developlment index, 3. Good health, Colo-Rectal Cancer, traditional healers, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Female, Colorectal Neoplasms, 6.4 Surgery, low income, Cohort study, Human, Developed Countrie, Adult, Aged, Emergencies, Humans, Logistic Models, Multivariate Analysis, Developed Countries, Developing Countries, medicine.medical_specialty, neoplasias colorrectales, Logistic Model, cancer, anastomosis, surgical, income, stomas, colostomy procedure, colorectal resection, end colostomy, emergency surgical procedure, human development index, delay, Anastomosis, Perforation (oil well), lcsh:Surgery, GlobalSurg Collaborative, NO, 03 medical and health sciences, Case mix index, Clinical Research, medicine, cancer, análisis multifactorial, emergency abdominal surgery, low income, surgial care, traditional healers, cancer, mortality, outcomes, delay, Elective Surgical Procedure, business.industry, Kirurgi, left colon resection, anastomosis, end colostomy, Evaluation of treatments and therapeutic interventions, lcsh:RD1-811, Odds ratio, mortality, Surgery, Prospective Studie, business, Digestive Diseases, colostomía, emergency abdominal surgery
Abstract

Background: End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods: This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results: In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6.9 per cent) from low-HDI, 254 (15.5 per cent) from middle-HDI and 1268 (77.6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57.5, 40.9 and 35.4 per cent; P, Medical Research Council, MR/N022114/1; National Institute for Health Research, 16/136/79

Published
2019

7. Long-term results of the treatment of secondary aorto-enteric fistulae by in situ replacement with cryopreserved arterial allografts

Author

Daniel, Guillaume, primary, Ahmed, Sabrina Ben, additional, Della Schiava, Nellie, additional, Louvancourt, Adrien, additional, Duprey, Ambroise, additional, Albertini, Jean Noel, additional, Favre (CHU Saint Etienne), Jean Pierre, additional, Millon, Antoine, additional, Feugier, Patrick, additional, and Rosset, Eugenio, additional

Published
2017
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8. Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications

Author

Cécile Louveau, Pierre Ellul, Anton Iftimovici, Julien Dubreucq, Charles Laidi, Quentin Leyrolle, Diane Purper-Ouakil, Sebastien Jacquemont, Stanislas Lyonnet, Catherine Barthélémy, Marie-Odile Krebs, Jing Bai, Paul Olivier, Boris Chaumette, GHU Paris Psychiatrie et Neurosciences, AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Etienne, Child Mind Institute, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Hôpital Saint Eloi (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), CHU Necker - Enfants Malades [AP-HP], GIS autisme et troubles du neuro-développement (GIS-Autisme et TND), Université de Tours (UT), McGill University = Université McGill [Montréal, Canada], Martinez Rico, Clara, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (ISC-MJ), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)

Subjects
Psychiatry and Mental health, Neurology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Biological Psychiatry
Abstract

International audience; On June 2022, the 2nd Webinar "Neurodevelopmental Disorders (NDD) without boundaries took place at the Imagine Institute in Paris and was broadcasted live and in replay. The aim of this webinar is to address NDD in a dimensional rather than in a categorical approach. Several speakers were invited to present their researches on the subject. Classifications in NDD were discussed: irritability in NDD, involvement of the immune system in neurodevelopment, nutrition and gut microbiota modulate brain inflammation and neurodevelopment, co-occurring conditions in autistic adolescents and adults without intellectual disability. Classifications in psychiatric disorders were asked: mapping the effect of genes on cognition and autism risk, epigenetics and symptomatic trajectory in neurodevelopmental disorders, the autism-schizophrenia continuum in two examples: minor neurological signs and EEG microstates, the cerebellum in schizophrenia and autism: from imaging to intervention perspectives. Both genetic and environmental factors, along with clinical and imaging features, argue toward a continnum between NDD but also with adult psychiatric presentations. This new paradigm could modify the therapeutic strategy, with the development of large-spectrum treatments or new psychotherapies addressing co-occuring symptoms. The complexity and the heterogeneity of NDD apply well to the next scientific and political challenges: developing international convergence to push back the frontiers of our knowledge. This article is a summary of the 2nd webinar "Neurodevelopmental Disorders (NDD) without boundaries: research and interventions beyond classifications" sponsored by the French National Academy of Medicine, the autism and neurodevelopmental disorders scientific interest group (GIS), the International Research Network Dev-O-Psy and the French Institute of Psychiatry (GDR3557). Oral presentations are available as a replay on the following website (in French): https://autisme-neurodev.org/evenements/2022/04/12/tnd-sans-frontieres-la-recherche-et-les-interventions-au-dela-des-classifications/ .

Published
2023

9. Pulmonary embolism detection on venous thrombosis ultrasound images with bi-dimensional entropy measures: preliminary results

Author

Jamin, Antoine, Hoffmann, Clément, Mahé, Guillaume, Bressollette, Luc, Humeau-Heurtier, Anne, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA), Laboratoire d'Etudes et de Recherche en Informatique d'Angers (LERIA), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Open access funding provided by University of Angers.

Subjects
[SPI]Engineering Sciences [physics], pulmonary embolism, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, bidimensional entropy, ultrasound images
Abstract

International audience; Background: Venous thromboembolism (VTE) is a common health issue. A clinical expression of VTE is a deep vein thrombosis (DVT) that may lead to pulmonary embolism (PE), a critical illness. When DVT is suspected, an ultrasound exam is performed.However, the characteristics of the clot observed on ultrasound images cannot be linked with the presence of PE. Computed tomography angiography is the gold standard to diagnose PE. Nevertheless, the latter technique is expensive and requires the use of contrast agents.Purpose: In this article, we present an image processing method based on ultrasound images to determine whether PE is associated or not with lower limb DVT. In terms of medical equipment, this new approach (Doppler ultrasound image processing) is inexpensive and quite easy.Methods: With the aim to help medical doctors in detecting PE, we herein propose to process ultrasound images of patients with DVT. After a first step based on histogram equalization, the analysis procedure is based on the use of bi-dimensional entropy measures. Two different algorithms are tested: the bi-dimensional dispersion entropy (DispEn2D) mesure and the bi-dimensional fuzzy entropy (FuzEn2D) mesure. Thirty-two patients (12 women and 20 men, 67.63±16.19 years old), split into two groups (16 with and 16 without PE), compose our database of around 1490 ultrasound images (split into seven different sizes from 32x32 px to 128x128 px). p-values, computed with the Mann-Whitney test, are used to determine if entropy values of the two groups are statistically significantly different. Receiver operating characteristic (ROC) curves are plotted and analyzed for the most significant cases to define if entropy values are able to discriminate the two groups.Results: p-values show that there are statistical differences between FuzEn2D of patients with PE and patients without PE for 112x112 px and 128x128px images. Area under the ROC curve (AUC) is higher than 0.7 (threshold for a fair test) for 112x112 and 128x128 images. The best value of AUC (0.72) is obtained for 112x112 px images.

Published
2023

10. Effect of weight-adjusted intermediate-dose versus fixed-dose prophylactic anticoagulation with low-molecular-weight heparin on venous thromboembolism among noncritically and critically ill patients with COVID-19: the COVI-DOSE trial, a multicenter, randomised, open-label, phase 4 trial

Author

Zuily, Stéphane, Lefèvre, Benjamin, Sanchez, Olivier, Empis de Vendin, Ombeline, de Ciancio, Guillaume, Arlet, Jean-Benoît, Khider, Lina, Terriat, Béatrice, Greigert, Hélène, Robert, Céline, Louis, Guillaume, Trinh-Duc, Albert, Rispal, Patrick, Accassat, Sandrine, Thiery, Guillaume, Montani, David, Azarian, Réza, Meneveau, Nicolas, Soudet, Simon, Le Mao, Raphaël, Maurier, François, Le Moing, Vincent, Quéré, Isabelle, Yelnik, Cécile, Lefebvre, Nicolas, Martinot, Martin, Delrue, Maxime, Benhamou, Ygal, Parent, Florence, Roy, Pierre-Marie, Presles, Emilie, Goehringer, François, Mismetti, Patrick, Bertoletti, Laurent, Rossignol, Patrick, Couturaud, Francis, Wahl, Denis, Thilly, Nathalie, Laporte, Silvy, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de Cardiologie [CHRU Nancy], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHR de Metz-Thionville, Centre Hospitalier Agen-Nérac, Hôpital Bicêtre, Université Paris-Saclay, Centre Hospitalier de Versailles André Mignot (CHV), Department of Cardiology, University Hospital Jean Minjoz, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), UNEOS, Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Lapeyronie [Montpellier] (CHU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Lille, CHU Lille, Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpitaux Civils de Colmar, Service d’Hématologie Biologique [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA), CHU d'Angers [Département Urgences], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Université Jean Monnet - Saint-Étienne (UJM), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Service de Chirurgie Vasculaire [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Centre Hospitalier Princesse Grace, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), French Ministry of Health, CAPNET, Grand-Est Region, Grand-Nancy Métropole., and COVI-DOSE investigators: Stéphane Zuily, Francis Couturaud, François Goehringer, Silvy Laporte, Patrick Mismetti, Emilie Presles, Patrick Rossignol, Nathalie Thilly, Denis Wahl, Thomas Lecompte, Emmanuel Oger, Marie-Antoinette Sevestre, Florence Parent, Ygal Benhamou, Pierre-Marie Roy, Tristan Gigante, Morgane Gilg, Pierre-Luc Maclot, Bénédicte Rossignol, Jonathan Udot, Hélène Bouteille, Andréa Buchmuller, Céline Peurière, El Mehdi Siaghy, Valérie Bouaziz, Charlotte Daguin, Benjamin Grosjean, Véronique Saunier, Laurence Verger, Madlyne Jacquot, Nadine Petitpain, Martin Charly, Laurent Tordella, Emilie Presles, Guillaume Baronnet, Elisabeth Baux, Athanase Benetos, Jean-Baptiste Blanvillain, Marie Conrad, Guilhem Courte, Aurélie Cravoisy-Popovic, Virginie Dufrost, Sébastien Gibot, Philippe Guerci, Laure Joly, Antoine Kimmoun, Matthieu Koszutski, Alexandrine Larue, Bruno Levy, Marie-Reine Losser, Mathieu Mattei, Lionel Nace, Emmanuel Novy, Pierre Perez, Jean-Pierre Pertek, Camille Rigaux, Alexis Sauvage, Evelyne Schvoerer, Carine Thivilier, Lev Volkov, Piotr Zieminski, Manil Benlounes, Charles Cheng, Jean-Baptiste de Fréminville, Grégoire Détriché, Emmanuel Flammarion, Guillaume Goudot, Amer Hamdan, Raphaël Hindré, Corina Manoli, Emmanuel Messas, Adrien Michon, Tristan Mirault, Jean Pastré, Marie-Aude Penet, Benjamin Planquette, Geoffroy Volle, Rémy Hamdan, Aline Laubriet-Jazayeri, Vincent Petit, Lionel Piroth, Jean Pierre Quenot, Mélissa Saccu, Damien Barraud, Zoé Cavalli, Rostane Gaci, Mathilde Andreu, Laurent Bertoletti, Andréa Buchmuller, Elodie De Magalhaes, Sophie Bulifon, Athénaïs Boucly, Nathan Ebstein, Marc Humbert, Xavier Jaïs, Mitja Jevnikar, Laurent Savale, Andrei Horia Seferian, Charlotte Colin, Timothée Ganem, Mehdi Roumila, Romain Chopard, Matthieu Besutti, Basile Mouhat, Claire Andrejak, Stéphane Dupas, Gaëlle Le Roy, Santhi Samy-Modeliar, Anne Coste, Alexandre Fauche, David Goetghebeur, Christophe Gut-Gobert, Clément Hoffmann, Baptiste Hourmant, Cécile L'hévéder, Emmanuelle Lemoigne, Olivier Nepveu, Raphaël Paret, Gaël Picart, Saïd Azerkan, Chadia Boudaa, Julien Campagne, Peter Eszto, Benoît Godbert, Jean-François Guichard, Marion Heschung, Antoine Legoff, Jacques Mariot, Pascale Martin, Magalie Mercy, Julie Perrin, Stéphane Raymond, Nathalie Vernier, Pierre Fesler, Pierrick Henneton, Cédric Mercuzot, Nathalie Pansu, Lucas Perez, Loïc Andre, Edgar Bakhache, Marie-Charlotte Chopin, Marie Gilbert, Marc Lambert, Mohammad Ryadh Pokeerbux, François Danion, Yves Hansmann, Estelle Rougier, Yvon Ruch, Dominique Stéphan, Axel Ursenbach, Isabelle Connerade, Simon Gravier, Damien Kayser, Jean-Marc Michel, Mahsa Mohseni, Waël Younes, Ruxandra Burlacu, Amanda Lopes, Stéphane Mouly, Kladoum Nassarmadji, Damien Sène, Virginie Siguret, Alain Stepanian, Cédric Annweiler, Antoine Brangier, Vincent Dubee, Samir Henni, Jeanne Hersant, Jocelyne Loison, Léa Kern, Jean-Baptiste Laine, Claire Neveux-Brecheteau, Lucia Perez, Ruben Benainous, Bénédicte Giroux-Leprieur, Marilucy Lopez-Sublet, Saïda Khaled-Jousselin, Yohann Bernard, Amélie Amiot, Jessica Breistroff, Emilie Detry, Kadidiatou Diallo, Agnès Didier, Nathalie Dumont, Julie Egensperger, Aurélie Emmerich, Nelly François, Fanny Gallo, Valérie George, Quentin Gérome, Aurélie Gutehrle, Laure Lehman, Séverine Petit, Vanessa Piard, Maximilien Saint-Gilles, Olivier Terenzi, Amélie Marquette, Hélène Mortelette, Mathilde Audry, Amélie Cransac, Marine Maillard, Anaïs Boyer, Floriana Gallo, Arielle Urbing, Imane Zahaf, Alexandra Byczko, Amina Chaalal, Georgette Berlier, Corinne Bernabe, Souad Bezzeghoud, Caroline Chaudier, Carole Chauvet, Marina Davier, Carine Labruyere, Estelle Perrin, Michaël Pierre, Claire-Annissa Chekirine, Florence Voivret, Ramdane Meftali, Ouaffa Sabri, Anaïs Beulaygue, Julie Gall, Laure Girard, Soumia Haddaoui, Scheherazade Rami, Auriane Couderc, Aude Le Breton, Marie-Line Perruche, Cindy Claudon, Ludivine Roussel, Aude Barnier, Tiphaine Blanchard, Bénédicte Le Gall, Mélanie Pelouin, Anne-Sophie Veillon, Quam Aquereburu, Charlène Delaygue, Zahoua Ait Idir, Jérémy Drugeon, Déborah Dubrulle, Rabah Tezkratt, Anne-Sophie Frantz, Julie Drouaine, Jacqueline Dubois, Magali Eyriey, Elina Haerrel, Mélinda Beaudenon, Mialy Guenet, Thibaud Lecerf, Stéphanie Marechal-Girault, Sami Rehaiem, Romain Simon, Florence Dangeul-Potier, Morgane Goulvent, Souha Fliss, Fadhila Messani, Béatrice Mizejewski, Brigitte Mugnier, Valérie Opderbeck, Brigitte Risse

Subjects
Anticoagulation, Heparin, [SDV]Life Sciences [q-bio], COVID-19, Venous thromboembolism
Abstract

International audience; Background: Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that a weight-adjusted intermediate dose of anticoagulation may decrease the risk of venous thromboembolism COVID-19 patients.Methods: In this multicenter, randomised, open-label, phase 4, superiority trial with blinded adjudication of outcomes, we randomly assigned adult patients hospitalised in 20 French centers and presenting with acute respiratory SARS-CoV-2. Eligible patients were randomly assigned (1:1 ratio) to receive an intermediate weight-adjusted prophylactic dose or a fixed-dose of subcutaneous low-molecular-weight heparin during the hospital stay. The primary outcome corresponded to symptomatic deep-vein thrombosis (fatal) pulmonary embolism during hospitalization (COVI-DOSE ClinicalTrials.gov number: NCT04373707).Findings: Between May 2020, and April 2021, 1000 patients underwent randomisation in medical wards (noncritically ill) (80.1%) and intensive care units (critically ill) (19.9%); 502 patients were assigned to receive a weight-adjusted intermediate dose, and 498 received fixed-dose thromboprophylaxis. Symptomatic venous thromboembolism occurred in 6 of 502 patients (1.2%) in the weight-adjusted dose group and in 10 of 498 patients (2.1%) in the fixed-dose group (subdistribution hazard ratio, 0.59; 95% CI, 0.22-1.63; P = 0.31). There was a twofold increased risk of major or clinically relevant nonmajor bleeding: 5.9% in the weight-adjusted dose group and 3.1% in the fixed-dose group (P = 0.034).Interpretation: In the COVI-DOSE trial, the observed rate of thromboembolic events was lower than expected in patients hospitalized for COVID-19 infection, and the study was unable to show a significant difference in the risk of venous thromboembolism between the two low-molecular-weight-heparin regimens.

Published
2023

11. Thermal male contraception: A study of users’ motivation, experience, and satisfaction

Author

Samuel Joubert, Jessica Tcherdukian, Roger Mieusset, Jeanne Perrin, Département de Médecine Générale [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), University Department of General Medicine, Faculty of Medicine of Marseille, Aix-Marseille University, Marseille, France, Service Médecine de la Reproduction [CHU Toulouse], Pôle Femme-Mère-Couple [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Développement Embryonnaire, Fertilité et Environnement (DEFE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), AMP-CECOS Clinical-Biological Centre, AP-HM La Conception University Hospital, Marseille, France, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Aix Marseille Université (AMU)

Subjects
Male, contraceptive devices, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Motivation, men acceptance of health care, contraceptive devices couple male thermal contraception men acceptance of health care men satisfaction sexual satisfaction, Urology, Endocrinology, Diabetes and Metabolism, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Personal Satisfaction, Hormones, men satisfaction, Contraception, Endocrinology, Contraceptive Agents, couple, Reproductive Medicine, Humans, male thermal contraception, Experience And Satisfaction, sexual satisfaction
Abstract

International audience; Study question: What are the motivations, experience, and acceptability of thermal male contraception (TMC) in men using TMC as the only couple contraceptive ? Summary answer: Men wished to share the role of providing contraception in a couple and to avoid the use of hormones. Sexual satisfaction was significantly improved.What is known already: Two male contraceptive methods inducing spermatogenesis suppression have achieved contraceptive efficacy, on a large population for hormonal contraception and a smaller one for thermalcontraception (TC). The suppression of sperm counts to below 1 million/mL results in fertility rates commensurate with female pills. TC is obtained by wearing 15 hours/day a contraceptive underwear (CU) inducing a 2C increase in testicular temperature (Mieusset & Bujan 1994). As no commercially available male thermal contraceptive exists, little information regarding the acceptability of this approach to men has been reported and only one publication analysed the hypothetical acceptability of TMC (Amouroux et al. 2018). Study design, size, duration: We contacted 72 men who had started the CU testing phase between June 2011 and September 2019. The participants completed an anonymous online survey of 93 questions exploring population characteristics, contraceptive histories, motivations for choosing TC, patient experience at the successive phases of use, relations with partner and environment, and satisfaction with TC. Sexual life was evaluated by rating (1 to 4): frequency and pleasure of sexual intercourse, sexual desire, morning and intercourse erections. Participants/materials, setting, methods: Among men who had reached the contraception use phase, the quality ratings of sexual life were compared over time, from the contraceptive method used before TC (“N-1” method) to the 2 previous methods (“N-2” and “N-3”)): “N-3” versus “contraception use phase”, “N-3” versus “CU testing phase,” and “CU testing phase” versus “contraception use phase.” These comparisons were made for all 5 sexual life parameters by a paired samples Wilcoxon signed rank test. Main results and the role of chance: Sixty-seven men responded (93% response rate);63 participated in the survey (94% participation rate). The median age was 31 [21-52], 30 men (48%) had a Master’s degree or more, 49 (78%) had no child and 24 (38%) no parental project. Among the men whose couple’s contraception method immediately before TC (N-1) was a female method (n ¼ 36/63, 57%), the 2 main reasons for switching to a male method were the wish to share the role of providing contraception in a couple (n ¼ 31/36, 86%) and the willingness to take responsibility for contraception (n ¼ 21/36, 58%). The main motivations for choosing TC were “not using hormones” (n ¼ 59/63, 94%) and using a method regarded as “natural” (n ¼ 49/63, 78%). Most of men (68%) adopted the method in less than 2 weeks. During the contraception use phase (n ¼ 59 men), they described: i) significantly improved sexual satisfaction (3,49§0,29/4) compared to that experienced with previous contraceptive methods (3,27§0,58/4;p

Published
2022

12. Obesity in adult patients with inflammatory bowel disease: Clinical features and impact on disability. A cross-sectional survey from the GETAID

Author

Rose Al Bacha, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, Xavier Roblin, Anne Bourrier, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered Abitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Mathieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Matthieu Allez, Stephanie Viennot, Catherine Le Berre, David Laharie, Maria Nachury, Aurelien Amiot, Sara Tadbiri, Charlotte Gagniere, Jenny Tannoury, Benjamin Pariente, Pauline Wils, Carmen Stefanescu, Xavier Treton, Carole Martins, Mathieu Uzzan, Xavier Hébuterne, Nadia Arab, Virginie Cluzeau, Emilie Del Tedesco, Laurent Beaugerie, Philippe Seksik, Cecilia Landmann, Julien Kirchgesner, Harry Sokol, Laurent Siproudhis, Marie DeWitte, Catherine Reenaers, Gilles Boschetti, Claire Gay, Pauline Danion, Bernard Flourié, Georgia Malamut, Benedicte Caron, Olivier DeWitt, Sandie Pestour, Thomas Chateau, Camille Zallot, Jean-Marc Gornet, Clotilde Baudry, Arnaud Bourreille, Caroline Trang-Poisson, Nina Dib, Hedi Brixi, Guillaume Cadiot, Medina Boualit, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Lucile Boivineau, Mathurin Fumery, Ludovic Caillo, Pauline Riviere, Florian Poullenot, Benoit Coffin, Henri Duboc, Stephane Nahon, Noemie Tavernier, Marion Simon, Baya Coulibaly, Morgane Amil, Duveau Nicolas, Sherine Khater, Mehdi Kaassis, Felix Goutorbe, Driffa Moussata, Laurence Picon, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Nord [CHU - APHM], Immunité muqueuse et vaccination, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), CHU Rouen, Normandie Université (NU), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Liège (CHU-Liège), Hospices Civils de Lyon (HCL), Hôpital Cochin [AP-HP], Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Grenoble, Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hopital Saint-Louis [AP-HP] (AP-HP), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Groupe d’Étude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID), and This study was supported by Abbvie.

Subjects
Crohn's disease, Disability, Ulcerative colitis, Hepatology, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Fatigue, Inflammatory bowel disease, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background: In recent years, an increasing prevalence of obesity in inflammatory bowel disease (IBD) has been observed. However, only a few studies have focused on the impact of overweight and obesity on IBD-related disability.Aims: To identify the factors associated with obese and overweight patients with IBD, including IBD-related disability.Patients and methods: In this cross-sectional study, we included 1704 consecutive patients with IBD in 42 centres affiliated with the Groupe d'Etude Therapeutique des Affections Inflammatoires du tube Digestif (GETAID) using a 4-page questionnaire. Factors associated with obesity and overweight were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals).Results: The prevalence rates of overweight and obesity were 24.1% and 12.2%, respectively. Multivariable analyses were stratified by age, sex, type of IBD, clinical remission and age at diagnosis of IBD. Overweight was significantly associated with male sex (OR = 0.52, 95% CI [0.39-0.68], p < 0.001), age (OR = 1.02, 95% CI [1.01-1.03], p < 0.001) and body image subscore (OR = 1.15, 95% CI [1.10-1.20], p < 0.001) (Table 2). Obesity was significantly associated with age (OR = 1.03, 95% CI [1.02-1.04], p < 0.001), joint pain subscore (OR = 1.08, 95% CI [1.02-1.14], p < 0.001) and body image subscore (OR = 1.25, 95% CI [1.19-1.32], p < 0.001) (Table 3).Conclusion: The increasing prevalence of overweight and obesity in patients with IBD is associated with age and poorer body image. A holistic approach to IBD patient care should be encouraged to improve IBD-related disability and to prevent rheumatological and cardiovascular complications.

Published
2023

13. Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID

Author

Amiot, Aurelien, Chaibi, Sayma, Bouhnik, Yoram, Serrero, Melanie, Filippi, Jerome, Roblin, Xavier, Bourrier, Anne, Bouguen, Guillaume, Franchimont, Denis, Savoye, Guillaume, Buisson, Anthony, Louis, Edouard, Nancey, Stephane, Abitbol, Vered, Reimund, Jean-Marie, Dewit, Olivier, Vuitton, Lucine, Mathieu, Nicolas, Peyrin-Biroulet, Laurent, Gilletta, Cyrielle, Allez, Matthieu, Viennot, Stephanie, Le Berre, Catherine, Dib, Nina, Brixi, Hedia, Painchart, Claire, Plastaras, Laurianne, Altwegg, Romain, Fumery, Mathurin, Caillo, Ludovic, Laharie, David, Nachury, Maria, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Henri Mondor, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Nord [CHU - APHM], Immunité muqueuse et vaccination, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Liège (CHU-Liège), Hospices Civils de Lyon (HCL), Service de Gastro-entérologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Grenoble, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hopital Saint-Louis [AP-HP] (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Bordeaux [Bordeaux], Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and This study was supported by Abbvie

Subjects
Crohn’s disease, disability, inflammatory bowel disease, fatigue, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ulcerative colitis
Abstract

International audience; Background: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined.Aims: To identify the factors associated with fatigue in a large population of patients with IBD.Patients and methods: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals).Results: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5.Conclusion: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.

Published
2023

14. Correction: Efficacy of ustekinumab, vedolizumab, or a second anti-TNF agent after the failure of a first anti-TNF agent in patients with Crohn’s disease: a multicentre retrospective study

Author

Rayer, Cassandra, Nachury, Maria, Bourreille, Arnaud, Roblin, Xavier, Peyrin-Biroulet, Laurent, Viennot, Stephanie, Flamant, Mathurin, Laharie, David, Caron, Bénédicte, Dewitte, Marie, Siproudhis, Laurent, Fumery, Mathurin, Bouguen, Guillaume, CHU Pontchaillou [Rennes], Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Clinique Jules-Vernes [Nantes], CHU Bordeaux [Bordeaux], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Nutrition, Métabolismes et Cancer (NuMeCan), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Gastroenterology, General Medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2023

15. Effectiveness of golimumab intensification in ulcerative colitis: A multicentric prospective study

Author

Mathurin Fumery, Stéphane Nancey, Jérôme Filippi, Romain Altwegg, Xavier Hébuterne, Gilles Boshetti, Mathilde Barraud, Jonathan Meynier, Stéphane Paul, Xavier Roblin, CHU Amiens-Picardie, Registre EPIMAD, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Immunité muqueuse et vaccination, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Infection bactérienne, inflammation, et carcinogenèse digestive, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université Pierre et Marie Curie - Paris 6 (UPMC), Direction de la recherche clinique et de l'innovation [CHU Amiens], Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Service d'hépato-gastroentérologie

Subjects
Hepatology, Gastroenterology, Pharmacology (medical), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Introduction: Loss of response to golimumab occurs in nearly 40% of patients with ulcerative colitis (UC). Unlike others anti-TNF, no study has reported a correlation between serum golimumab level and response to drug intensification. The objective of this study was to evaluate the effectiveness and safety of golimumab intensification and to identify the best threshold of serum golimumab before drug intensification predictive of response.Patients and methods: We included all consecutive patients with active UC with loss of response to golimumab in a prospective multicentric cohort study. Patients with loss of response at 50 mg q4 weeks (W) and 100 mg q4W underwent therapeutic intensification at 100 mg q4W and 100 mg q2W, respectively. Effectiveness and safety were assessed between Weeks 2 and 4 (visit 2) and between Weeks 4 and 8 (visit 3) after intensification. Serum level and anti-golimumab antibodies were evaluated at each medical visit (Lisa Tracker, Theradiag France).Results: A total of 47 UC patients (Female, 50%; median age, 39 years (IQR, 27-52)) treated with golimumab for a median of 20.4 weeks (IQR, 10.7-38.3) were included. The median partial Mayo score was 6 (IQR, 5-7), and the median endoscopic Mayo score was 3 (IQR, 2-3). The median golimumab serum level before intensification was 2.23 μg/mL (IQR, 1.02-3.96) and only one patient (2.1%) had anti-drug antibodies. At Visit 2 (Week 2-4), 40% patients experienced clinical response, 10% clinical remission, 33% endoscopic response and 23% endoscopic remission. At Visit 3 (Week 4-8), 44% of patients had clinical response, 22% of patients had clinical remission, 45% of patients had endoscopic response, and 41% of patients had endoscopic remission. The median golimumab levels before intensification do not differ between responders and non-responders (2.13 μg/ml (0.76-2.76) and 3.37 μg/ml (IQR, 1.08-4.67), respectively; p = 0.14) assessed at Visit 3. Golimumab intensification to 100 mg q4W (vs q2W) (OR 1.98, 95% CI [1.06-3.70]; p = 0.032) was significantly associated with clinical remission at Visit 3. Serum drug level at baseline or the presence of antidrug antibodies were not associated with clinical or endoscopic remission/response. Two serious adverse events (one infection and one UC flare) were reported during the 24-week follow-up.Conclusion: In this prospective multicentric study, half of patients recaptured response following golimumab intensification in UC. Therapeutic drug monitoring did not predict response after optimisation of golimumab.

Published
2023

16. Local Food Systems under Global Influence: The Case of Food, Health and Environment in Five Socio-Ecosystems

Author

Michael Rapinski, Richard Raymond, Damien Davy, Thora Herrmann, Jean-Philippe Bedell, Abdou Ka, Guillaume Odonne, Laine Chanteloup, Pascal Jean Lopez, Éric Foulquier, Eduardo Ferreira da Silva, Nathalie El Deghel, Gilles Boëtsch, Véronique Coxam, Fabienne Joliet, Anne-Marie Guihard-Costa, Laurence Tibère, Julie-Anne Nazare, Priscilla Duboz, Éco-Anthropologie (EA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), German Centre for Integrative Biodiversity Research (iDiv), University of Oulu, Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte Internationale 'Environnement Santé Sociétés' (ESS), Centre National de la Recherche Scientifique (CNRS), Université de Lausanne = University of Lausanne (UNIL), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Littoral, Environnement, Télédétection, Géomatique (LETG - Brest), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université (Nantes Univ)-Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Humanités, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université (Nantes Univ), Departamento de Geociencias, Ambiente e Ordenamento do Territorio (DGAOT), Universidade do Porto = University of Porto, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Espaces et Sociétés (ESO), Normandie Université (NU)-Normandie Université (NU)-Le Mans Université (UM)-Université d'Angers (UA)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (Nantes Univ - IGARUN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité (BABEL), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre d'Etude et de Recherche Travail Organisation Pouvoir (CERTOP), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), UNH Space Science Center [Durham] (SSC), University of New Hampshire (UNH), Lyvet, Nathalie, Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux - - DRIIHM / IRDHEI2011 - ANR-11-LABX-0010 - LABX - VALID, Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (NantesUniv – IGARUN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (NantesUniv – IGARUN), Normandie Université (NU)-Normandie Université (NU)-Le Mans Université (UM)-Université d'Angers (UA)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (NantesUniv – IGARUN), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)

Subjects
[SDE] Environmental Sciences, Canada, Portugal, Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction, Management, Monitoring, Policy and Law, Senegal, epidemiologic transition, French Guiana, chronic diseases, [SDE]Environmental Sciences, One Health, nutrition and food transition, Guadeloupe, globalization
Abstract

International audience; Globalization is transforming food systems around the world. With few geographical areas spared from nutritional, dietary and epidemiological transitions, chronic diseases have reached pandemic proportions. A question therefore arises as to the sustainability of local food systems. The overall purpose of this article is to put in perspective how local food systems respond to globalization through the assessment of five different case studies stemming from an international research network of Human-Environment Observatories (OHM), namely Nunavik (Québec, Canada), Oyapock (French Guiana, France), Estarreja (Portugal), Téssékéré (Senegal) and Littoral-Caraïbes (Guadeloupe, France). Each region retains aspects of its traditional food system, albeit under different patterns of influence modelled by various factors. These include history, cultural practices, remoteness and accessibility to and integration of globalized ultra-processed foods that induce differential health impacts. Furthermore, increases in the threat of environmental contamination can undermine the benefits of locally sourced foods for the profit of ultra-processed foods. These case studies demonstrate that: (i) the influence of globalization on food systems can be properly understood by integrating sociohistorical trajectories, socioeconomic and sociocultural context, ongoing local environmental issues and health determinants; and (ii) long-term and transverse monitoring is essential to understand the sustainability of local food systems vis-à-vis globalization.

Published
2023

17. Use of imaging modalities for decision-making in inflammatory bowel disease

Author

Stéphane Nancey, Mathurin Fumery, Mathias Faure, Gilles Boschetti, Claire Gay, Laurent Milot, Xavier Roblin, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Université de La Réunion - UFR Santé (UR UFRS), Université de La Réunion (UR), Hôpital Edouard Herriot [CHU - HCL], Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)

Subjects
Crohn’s disease, ultrasound, Gastroenterology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MRI, clinical decision, ulcerative colitis
Abstract

Cross-sectional magnetic resonance enterography (MRE) and intestinal ultrasonography (IUS) provide valuable and noninvasive information to accurately assess disease activity, severity, and extent; detect complications; and monitor the response to treatment, as well as predict the postoperative recurrence of Crohn’s disease and a negative disease course. Therefore, both imaging modalities are emerging as pivotal diagnostic tools to achieve the emerging therapeutic target of transmural healing associated with better disease outcomes. Despite its numerous potential advantages over endoscopy and even MRE and its good availability, IUS is still widely underused to monitor and manage inflammatory bowel disease (IBD) patients and help in making clinical decisions in routine practice. This situation is clearly due to the absence of validated, reliable, and responsive indices, as well as the lack of trained gastroenterologists and radiologists, as IUS is a component of radiologist expertise in several countries but not yet integrated into the training program of gastroenterologists. However, there is an increasing body of evidence in the literature that IUS and MRE are both becoming essential imaging resources to help clinicians in making reliable decisions. Here, we discuss the up-to-date evidence about the usefulness and performance of cross-sectional imaging, focusing on the ability of bowel US and MRE to aid clinical decision-making for the optimal management and monitoring of IBD.

Published
2023

18. How can we improve the acceptability of vaccination against Human Papillomavirus (HPV) in France? An original qualitative study with focus groups comprising parents and school staff, interviewed separately

Author

Ailloud, Julien, Branchereau, Marion, Fall, Estelle, Juneau, Catherine, Partouche, Henri, Bonnay, Stéphanie, Oudin-Doglioni, Damien, Michel, Morgane, Gagneux-Brunon, Amandine, Bruel, Sébastien, Thilly, Nathalie, Gauchet, Aurélie, Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social (LIP-PC2S), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Grenoble Alpes (UGA), Centre Régional de Coordination des Dépistages des Cancers [Angers] (CRCDC Pays de la Loire), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), McGill University = Université McGill [Montréal, Canada], Département de Médecine Générale, Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Hôpital Robert Debré, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Faculté de Médecine Jacques Lisfranc [Université Saint-Etienne], Université Jean Monnet - Saint-Étienne (UJM), Département Méthodologie Promotion Investigation [CHRU Nancy] (MPI), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), and The PrevHPV study is conducted with the support of IreSP and Inserm, and with financial support from ITMO Cancer AVIESAN (Alliance Nationale pour les Sciences de la Vie et de la Santé/ National Alliance for Life Sciences & Health) within the framework of the Cancer Plan

Subjects
Hpv, Vaccine Acceptance/Hesitancy, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Vaccination, Human Papillomavirus, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Decision-making
Abstract

International audience; Background: It has been proven that vaccination is effective against Human Papillomavirus (HPV) infections, genital warts, and pre-cancerous and cancerous cervical lesions. Nevertheless, the HPV vaccine coverage of 37.4% in 2021 in France is one of the lowest in Europe. To explore and understand the reason why French population is so late compared to its neighbours, we carried out focus groups with mothers and with National Education school staff. We aimed to identify knowledge and perceptions of HPV in both study populations, as well as factors influencing HPV vaccination.Methods: Between January 2020 and March 2021, we performed a qualitative study using an inductive approach with a thematic content analysis (TCA). We conducted semi-structured focus groups with 29 people including 15 mothers of adolescents in middle schools and 14 school staff from the national education system.Results: Different factors influenced the decision-making process of parents and school staff: knowledge and perceptions of HPV and its vaccine, sources of information about HPV and vaccination. Mothers' discourses differed from those of school staff. They mentioned the importance of gynaecological monitoring and the negative image of pharmaceutical companies, and questioned internet as a reliable source of information. For their part, school staff mentioned cultural and/or religious affiliation, municipalities’ role to inform the population, and ethical dilemma or logistical challenges regarding HPV vaccination in schools.Conclusion: The results of these focus groups provided information on which elements may harm or help HPV vaccination. Identified perceptions, beliefs, knowledge, barriers, and facilitators will help us to build an intervention program focus on general practitioners (GP), school staff, parents, and adolescents.

Published
2023

19. Adalimumab in biologic-naïve patients with Crohn’s disease after resolution of an intra-abdominal abscess: a prospective study from the GETAID

Author

Yoram Bouhnik, Guillaume Pineton de Chambrun, Jérôme Lambert, Maria Nachury, Philippe Seksik, Romain Altwegg, Lucine Vuitton, Carmen Stefanescu, Stéphane Nancey, Alexandre Aubourg, Mélanie Serrero, Jérôme Filippi, Kristell Desseaux, Stéphanie Viennot, Vered Abitbol, Madina Boualit, Arnaud Bourreille, Cyrielle Giletta, Anthony Buisson, Xavier Roblin, Nina Dib, Georgia Malamut, Aurélien Amiot, Mathurin Fumery, Edouard Louis, Yasmine Elgharabawy, Laurent Peyrin-Biroulet, Jacques Moreau, Xavier Treton, Charlotte Mailhat, Justine Pollet, Carole Martins, Guillaume Savoye, Noémie Tavernier, Jean-Yves Mary, Magali Zappa, Claire Painchart, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Hopital Saint-Louis [AP-HP] (AP-HP), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire de Nice (CHU Nice), Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Gastro-entérologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Service d'Hépato Gastroenterologie [CHU Amiens-Picardie], CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), and Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie

Subjects
Crohn’s disease, surgery, Hepatology, adalimumab, Gastroenterology, abscess, anti-TNF, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background & aims: The management of intra-abdominal abscesses complicating Crohn's disease (CD) is challenging and surgery with delayed intestinal resection is often recommended. The aims of this study were to estimate the success rate of adalimumab (ADA) in CD patients with an intra-abdominal abscess resolved without surgery, and to identify predictive factors for success.Methods: A multicenter, prospective study was conducted in biologic-naïve CD patients with resolved intra-abdominal abscess treated with ADA with a two-year follow-up. The primary endpoint was ADA failure at W24 defined as a need for steroids after W12, intestinal resection, abscess recurrence, and clinical relapse. Secondary post-hoc endpoint was the long-term success defined as the survival without abscess relapse or intestinal resection at W104. The factors associated with ADA failure at W24 and W104 were identified using a logistic and a cox regression, respectively.Results: From April 2013 to December 2017, 190 patients from 27 GETAID centers were screened, and 117 were included in the analysis. Fifty-eight (50%) patients were male and the median age at baseline was 28 years. At W24, 87 (74%, 95%CI: 65.5-82.0, n=117) patients achieved ADA success. Among the 30 patients with ADA failure, 15 underwent surgery. At W104, the survival rate without abscess recurrence or surgery was 72·9% (95%CI: 62.1-79.8, n=109). Abscess drainage was significantly associated with ADA failure at W24 (OR=4.18; 95%CI: 1.06-16.5; p=0.043). Disease duration (HR=1.32, 95%CI: 1.09-1.59, p=0.008), abscess drainage (HR=5.59, 95%CI: 2.21-14.15, p=0.001), and inflammatory changes in mesenteric fat (HR=0.4, 95%CI: 0.17-0.94, p=0.046) were significantly associated with ADA failure at W104.Conclusion: Provided that the abscess was carefully managed before initiating medical treatment, this study showed the high efficacy of ADA in the short and long term in biologic-naïve patients with CD complicated by an intra-abdominal abscess.

Published
2023

20. Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination

Author

Véronique Barateau, Loïc Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Hélénie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stéphane Paul, Thierry Walzer, Sophie Trouillet-Assant, Thierry Defrance, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Laboratoire Commun de Recherche Hospices Civils de Lyon – bioMérieux (Cancer Biomarkers Research Group), Hospices Civils de Lyon (HCL)-BIOMERIEUX, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR_T9405), Université de Lyon-Université de Lyon-Université Gustave Eiffel, BIOASTER Microbiology Technology Institute [Lyon], Service de Biostatistiques [Lyon], and Hôpital Edouard Herriot [CHU - HCL]

Subjects
EPIDEMIOLOGIE, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, SANTE, TOLERANCE HUMAINE, VACCINATION, PANDEMIE, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, SARS-COV-2, MEDICAMENT, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
Abstract

The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein–specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein–specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced T H 1 polarization of their SARS-CoV-2 spike protein–specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein–specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein–specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.

Published
2023

21. Efficacy of ustekinumab, vedolizumab, or a second anti-TNF agent after the failure of a first anti-TNF agent in patients with Crohn’s disease: a multicentre retrospective study

Author

Rayer, Cassandra, Maria, Nachury, Bourreille, Arnaud, Roblin, Xavier, Peyrin-Biroulet, Laurent, Viennot, Stephanie, Flamant, Mathurin, Laharie, David, Caron, Bénédicte, Dewitte, Marie, Siproudhis, Laurent, Fumery, Mathurin, Bouguen, Guillaume, Centre Hospitalier Universitaire [Rennes], Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Clinique Jules-Vernes [Nantes], CHU Bordeaux [Bordeaux], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, and Service des Maladies de l'Appareil Digestif [CHU Rennes]

Subjects
Anti-TNF, Crohn’s disease, Biological Products, Second line, Treatment strategy, Crohn Disease, Humans, Tumor Necrosis Factor Inhibitors, Ustekinumab, Vedolizumab, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Retrospective Studies
Abstract

International audience; Background - No study has performed a face-to-face comparison of biologics after the failure of the first anti-TNF agent in patients with Crohn's disease (CD). The aim of the study was to compare the efficacy of biologics in this setting. Methods - Patients with CD who were refractory to a first anti-TNF agent, and treated with ustekinumab (UST), vedolizumab (VDZ), or a second anti-TNF drug as a second-line biological agent at 10 French tertiary centres from 2013 to 2019 were retrospectively included in this study. Results - Among the 203 patients included, 90 (44%) received UST, 42 (21%) received VDZ and 71 (35%) received a second anti-TNF agent. The first anti-TNF agent was discontinued due to a primary nonresponse in 42 (21%) patients. At weeks 14-24, the rates of steroid-free remission were similar between the UST, VDZ and second anti-TNF groups (29%, 38% and 44%, respectively, p = 0.15). With a mean follow-up of 118 weeks, drug survival was shorter for patients who received ustekinumab treatment (p = 0.001). In the case of trough level less than 5 µg/ml, patients treated with a second anti-TNF agent had a higher postinduction remission rate (p = 0.002), and drug survival (p = 0.0005). No other relevant factors were associated with treatment efficacy, including trough levels greater than 5 µg/ml. Conclusions - VDZ, UST and a second anti-TNF agent exhibit similar efficacy in the short term, as second-biological line treatment in patients with CD who are refractory to a first anti-TNF agent, but shorter drug maintenance is observed for patients treated with UST.

Published
2022

22. The Economic Burden of Severe Osteoporotic Fractures in the French Healthcare Database: The FRACTOS Study

Author

Thierry Thomas, Florence Tubach, Geoffray Bizouard, Anne Crochard, Frédérique Maurel, Laure Perrin, Cédric Collin, Christian Roux, Julien Paccou, Service de Rhumatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), IQVIA, UCB Pharma S.A.[Braine-l'Alleud], UCB Pharma [Brussels], Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 (MABLab (ex-pmoi)), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Male, MESH: Humans, Hip Fractures, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], HEALTH ECONOMICS, MESH: Health Care Costs, Financial Stress, Health Care Costs, MESH: Hip Fractures, OSTEOPOROSIS, FRACTURE PREVENTION, MESH: Male, MESH: Osteoporotic Fractures, THERAPEUTICS, Humans, Orthopedics and Sports Medicine, GENERAL POPULATION STUDIES, MESH: Financial Stress, Osteoporotic Fractures, MESH: Osteoporosis
Abstract

International audience; Osteoporosis carries a high medical, economic, and societal burden principally because of the risk of severe fractures. The objective of this cost-of-illness study was to describe health resource utilization and associated costs in all patients aged ≥50 years hospitalized for a severe osteoporotic fracture over a 6-year period (2009 to 2014) in France. Data were extracted from the French national healthcare database (SNDS) on all health care resource utilization between the index date (date of hospitalization for first fracture during the enrollment period) and study end (December 31, 2016) or until the patient died. Costing was restricted to direct costs and determined from the payer perspective. Variables related to costs were identified through multivariate logistic regression analysis. A total of 356,895 patients were included (median follow-up 39.1 months). In the year after the index fracture, 36,622 patients (10.5%) were rehospitalized for a fracture-related reason. Only 18,474 (5.3%) underwent bone densitometry and 58,220 (16.7%) received a specific treatment. The total annual per capita osteoporosis-related cost in the year after the index severe osteoporotic fracture was €18,040 (from €8598 for multiple ribs to €21,085 for hip fracture) of which €17,905 was incurred by fracture-related costs. The cost incurred by management of osteoporosis was €135. Over years 2 to 5, the mean annual per capita costs of fracture treatment (€806, mostly attributable to the treatment of refractures) continued to dominate those of osteoporosis management (€99). Total annual cost of care was €1260 million (year 2014). Variables associated with higher cost were older age, male sex, site of fracture, a history of prior osteoporotic fracture, and the number of refracture events. The 5-year cost of severe osteoporotic fractures to the French health care system is high and mostly attributable to the treatment of refractures. Improved fracture prevention measures in patients with osteoporosis is crucial to reduce the economic burden of the disease. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

Published
2022

23. Prevalence of Self-Reported Venous Thromboembolism and Cardiovascular Risk Factors in Patients with Ulcerative Colitis: The GETAID FOCUS Study

Author

Guillo, Lucas, Amiot, Aurélien, Serrero, Mélanie, Altwegg, Romain, Roblin, Xavier, Atanasiu, Calina, Buisson, Anthony, Le Berre, Catherine, Reenaers, Catherine, Gornet, Jean-Marc, Laharie, David, Abitbol, Vered, Biron, Amélie, Caron, Bénédicte, Nancey, Stéphane, Chupin, Antoine, Blain, Antoine, Vuitton, Lucine, Caillo, Ludovic, Kirchgesner, Julien, Nachury, Maria, Peyrin-Biroulet, Laurent, Pariente, Benjamin, Beaugerie, Laurent, Seksik, Phillipe, Bourrier, Anne, Bourrreille, Arnaud, Desjeux, Ariadne, Savoye, Guillaume, Auzou, Stéphanie, Cadiot, Guillaume, Benezech, Alban, Mathieu, Nicolas, Malamut, Georgia, Amouriaux, Karine, Brixi, Hédia, Simon, Marion, Benitah, Daniel, Ah-Soune, Philippe, Fumery, Mathurin, Boschetti, Gilles, Gay, Claire, Vidon, Mathias, Fotsing, Ginette, Coffin, Benoit, Gilletta, Cyrielle, Reimund, Jean Marie, Bonnet-Dodel, Marie, Hôpital Nord [CHU - APHM], Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375) (EC2M3), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de gastro-entérologie [Henri Mondor AP-HP, Créteil], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Service de Gastro entérologie [Hôpital Paris Saint-Joseph], Hôpital Paris Saint-Joseph, Service d'Hépatologie Gastro-entérologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] (3IHP ), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre hospitalier universitaire de Nantes (CHU Nantes), Institut des maladies de l'appareil digestif [Nantes] (IMAD), Centre Hospitalier Universitaire de Liège (CHU-Liège), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Bordeaux [Bordeaux], Service de Gastro-entérologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Centre Hospitalier Universitaire de Reims (CHU Reims), Hôpital de Hautepierre [Strasbourg], Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC)-Fédération de Médecine Translationelle de Strasbourg (FMTS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Paris-Saclay, Institut Mutualiste de Montsouris (IMM), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Pfizer, Service de gastroentérologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Disease progression, Venous thromboembolism, Ulcerative colitis, Physiology, Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Heart disease risk factors
Abstract

FOCUS Study Group: Benjamin Pariente, Laurent Beaugerie, Phillipe Seksik, Anne Bourrier, Arnaud Bourrreille, Ariadne Desjeux, Guillaume Savoye, Stéphanie Auzou, Guillaume Cadiot, Alban Benezech, Nicolas Mathieu, Georgia Malamut, Karine Amouriaux, Hédia Brixi, Marion Simon, Daniel Benitah, Philippe Ah-Soune, Mathurin Fumery, Gilles Boschetti, Claire Gay, Mathias Vidon, Ginette Fotsing, Benoit Coffin, Cyrielle Gilletta, Jean Marie Reimund, Marie Bonnet-Dodel; International audience; Background and aims: Patients with inflammatory bowel disease have an increased risk of venous thromboembolism (VTE) and cardiovascular disease (CVD). The study aims to determine the prevalence of CVD and VTE risk factors in a large population of patients with ulcerative colitis (UC).Methods: We conducted a cross-sectional study in 33 French and Belgium referral centers. A questionnaire was developed to explore self-reported risk factors for VTE and CVD, based on the latest international guidelines, in consecutive patients with UC.Results: A total of 1071 patients with UC were included. There were 539 women (50.3%), and the median age of patients was 44 years [32; 57]. The median disease duration was 10 years [6; 17]. In the cohort, 36.5% of patients reported no cardiovascular risk factor (CVRF) and 72% had ≤ 1 CVRF. Regarding cardiovascular risk markers (CVRM) 36.9% of patients reported no CVRM and 78% had ≤ 1 CVRM. Of the 1071 patients, 91.3% of patients reported no VTE strong risk factor and 96% had ≤ 1 VTE moderate risk factor.Conclusion: This is the first cohort specifically designed to assess both VTE and CVD risks in patients with UC. More than one third of patients with UC had no CVRF and around three quarters had ≤ 1 CVRF. In addition, more than nine out of ten patients had no VTE strong risk factor and ≤ 1 moderate risk factor. Physicians should be aware of these factors in their patients.

Published
2022

24. Attitudes towards monkeypox vaccination among healthcare workers in France and Belgium: an element of complacency?

Author

Gagneux-Brunon, A., Dauby, N., Launay, O., Botelho-Nevers, E., Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université libre de Bruxelles (ULB), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
Microbiology (medical), Health Knowledge, Attitudes, Practice, Health Personnel, Vaccination, General Medicine, Infectious Diseases, Belgium, Attitude, Influenza Vaccines, Influenza, Human, Humans, France, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, Smallpox Vaccine
Abstract

International audience; No abstract available

Published
2022

25. Frequency and Predictors for Chronic Thromboembolic Pulmonary Hypertension after a first Unprovoked Pulmonary Embolism: results from PADIS studies

Author

Alexandre Fauché, Emilie Presles, Olivier Sanchez, Xavier Jaïs, Raphael Le Mao, Philippe Robin, Gilles Pernod, Laurent Bertoletti, Patrick Jego, Florence Parent, Catherine A. Lemarié, Florent Leven, Pierre‐Yves Le Roux, Pierre‐Yves Salaun, Michel Nonent, Philippe Girard, Karine Lacut, Laurent Savale, Solen Mélac, Marie Guégan, Patrick Mismetti, Silvy Laporte, Christophe Leroyer, David Montani, Francis Couturaud, Cécile Tromeur, Guy Meyer, Elisabeth Duhamel, Karine Provost, Dominique Mottier, Aurélia Le Hir, Stéphane Lenoir, Christian Lamer, Jean François Bergmann, Denis Wahl, Ludovic Drouet, Patrick Chevarier, Nicolas Monte, Florence Morvan, Véronique Kouassi, Nabahats Ibrir, Gaid El Asri, Pierre Yves Salaun, Pierre Yves Le Roux, Luc Bressollette, Philippe Quéhé, Simon Gestin, Jérôme Bahuon, Lucille Deloire, Benjamin Planquette, Yannick Jobic, Yves Etienne, Romain Didier, Loic Leroux, Hubert Galinat, Cédric Le Maréchal, Lénaïck Gourhant, Fanny Mingant, Emmanuelle Lemoigne, Luc De Saint Martin, Aurélien Delluc, Grégoire Le Gal, Nicolas Paleiron, Raphaël Le Mao, Christophe Pison, Philippe Guéret, Hervé Décousus, Sandrine Accassat, CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Etienne, F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Bicêtre, Pôle des Cardiopathies Congénitales du Nouveau-Né à L'adulte - Centre Constitutif Cardiopathies Congénitales Complexes M3C, Groupe Hospitalier Paris Saint-Joseph, Hôpital Marie-Lannelongue, Inserm U999, Université Paris-Saclay, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Grenoble, Université Grenoble Alpes (UGA), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), Université de Rennes (UR), CHU Pontchaillou [Rennes], Institut Mutualiste de Montsouris (IMM), PADIS-PE Investigators: Francis Couturaud, Patrick Mismetti, Christophe Leroyer, Guy Meyer, Olivier Sanchez, Patrick Jego, Gilles Pernod, Elisabeth Duhamel, Karine Provost, Florence Parent, Laurent Bertoletti, Cécile Tromeur, Dominique Mottier, Marie Guégan, Solen Mélac, Aurélia Le Hir, Philippe Girard, Stéphane Lenoir, Christian Lamer, Jean François Bergmann, Denis Wahl, Ludovic Drouet, Emilie Presles, Silvy Laporte, Patrick Chevarier, Nicolas Monte, Florence Morvan, Véronique Kouassi, Nabahats Ibrir, Gaid El Asri, Pierre Yves Salaun, Philippe Robin, Pierre Yves Le Roux, Luc Bressollette, Philippe Quéhé, Simon Gestin, Michel Nonent, Jérôme Bahuon, Lucille Deloire, Benjamin Planquette, Yannick Jobic, Yves Etienne, Romain Didier, Florent Leven, Loic Leroux, Hubert Galinat, Cédric Le Maréchal, Lénaïck Gourhant, Fanny Mingant, Karine Lacut, Emmanuelle Lemoigne, Luc De Saint Martin, Aurélien Delluc, Grégoire Le Gal, Nicolas Paleiron, Raphaël Le Mao, Christophe Pison, Philippe Guéret, Hervé Décousus, Sandrine Accassat, Jonchère, Laurent, Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], Pulmonary Hypertension, Risk Factors, Hypertension, Pulmonary, Incidence, [SDV]Life Sciences [q-bio], Chronic Disease, Clinical Studies, Humans, Anticoagulants, Hematology, Pulmonary Embolism, Aged
Abstract

International audience; Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary embolism's (PE) complication whose incidence and predictors are not precisely determined.Objective: To determine the frequency and predictors for CTEPH after a first unprovoked PE.Patients/methods: In a randomized trial comparing an additional 18-month warfarin versus placebo in patients after a first unprovoked PE initially treated with vitamin K antagonist for 6 months, we applied recommended CTEPH screening strategies through 8-year follow-up to determine cumulative incidence of CTEPH. CTEPH predictors were estimated using Cox models. Pulmonary vascular obstruction (PVO) and systolic pulmonary arterial pressure (sPAP) at PE diagnosis and 6 months were studied by receiver operating curves analysis. All CTEPH cases and whether they were incident or prevalent were adjudicated.Results: During a median follow-up of 8.7 years, 9 CTEPH cases were diagnosed among 371 patients, with a cumulative incidence of 2.8% (95% confidence interval [CI], 0.95-4.64), and of 1.31% (95%CI, 0.01-2.60) after exclusion of 5 cases adjudicated as prevalent. At PE diagnosis, PVO>45% and sPAP>56mmHg were associated with CTEPH with a hazard ratio (HR) of 33.00 (95%CI 1.64-667.00, p=0.02) and 12.50 (95%CI 2.10-74.80, p65 years, lupus anticoagulant antibodies and non-O blood groups were also predictive of CTEPH. PVO>14% and sPAP>34mmHg at 6-month were associated with CTEPH (HRs 63.90 [95%CI, 3.11-1310.00, p

Published
2022

26. Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review

Author

Marie-Fleur Durieux, Jean-Guillaume Lopez, Maher Banjari, Karine Passebosc-Faure, Marie-Pierre Brenier-Pinchart, Luc Paris, Gilles Gargala, Sabine Berthier, Julie Bonhomme, Cathy Chemla, Isabelle Villena, Pierre Flori, Emilie Fréalle, Coralie L’Ollivier, Florian Lussac-Sorton, José Gilberto Montoya, Estelle Cateau, Christelle Pomares, Loïc Simon, Dorothée Quinio, Florence Robert-Gangneux, Hélène Yera, Marc Labriffe, Anne-Laure Fauchais, Marie-Laure Dardé, Hôpital Dupuytren [CHU Limoges], Assistance Publique - Hôpitaux de Marseille (APHM), Service de Parasitologie Mycologie [CHU Limoges], CHU Limoges, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), COVID-Mucor study group, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Aliments Bioprocédés Toxicologie Environnements (ABTE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Microbiologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Reims (CHU Reims), Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE), Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Service des Agents Infectieux et Hygiène [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Service de Parasitologie-Mycologie [CHRU LIlle], Institut de Microbiologie [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Laboratoire de Parasitologie-Mycologie (CHU de Poitiers), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Laboratoire de Parasitologie-Mycologie, Nice, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Centre méditerranéen de médecine moléculaire (C3M), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], and The French National Reference Center for Toxoplasmosis received financial support by Santé Publique France (the national public health agency, https://www.santepubliquefrance.fr) for genotyping study, but no author has personally received grant.

Subjects
Infectious Diseases, Adrenal Cortex Hormones, Toxoplasmosis, Cerebral, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, Humans, Multicenter Studies as Topic, Toxoplasma, Immunosuppressive Agents, Autoimmune Diseases
Abstract

Background Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS therapy, excluded HIV-positive and transplant patients. Methods A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated with clinical data. Other cases were retrieved through a questionnaire sent to all French parasitology and internal medicine departments. Furthermore, a systematic literature review was conducted. Results 61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) were cerebral toxoplasmosis. The most common associated AID were rheumatoid arthritis (28%) and most frequent treatments were antimetabolites (44.3%). Corticosteroids were involved in 60.7% of cases. Patients had a favorable outcome (50.8%) but nine did not survive. For 12 cases, a successful Toxoplasma strain characterization suggested the possible role of this parasitic factor in ocular cases. Conclusion Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment.

Published
2022

27. Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: Ancillary data from a prospective outcome study

Author

Righini, Marc, Robert‐Ebadi, Helia, Cremonesi, Alessio, Elias, Antoine, Sanchez, Olivier, Le Moigne, Emmanuelle, Schmidt, Jeannot, Le Gall, Catherine, Cornuz, Jacques, Aujesky, Drahomir, Roy, Pierre‐Marie, Chauleur, Céline, Rouyer, Frédéric, Poletti, Pierre‐Alexandre, Moreau, Caroline, Le Gal, Grégoire, CT-PE-Pregnancy group, Faculté de médecine [Genève], Geneva University Hospitals and Geneva University, University Children’s Hospital Zurich, Universität Zürich [Zürich] = University of Zurich (UZH), Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), CHU Louise Michel [Clermont-Ferrand], CHU Clermont-Ferrand, Centre hospitalier Argenteuil (CH Argenteuil), Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Bern University Hospital [Berne] (Inselspital), University of Bern, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Biologie Intégrative du Tissu Osseux (LBTO), Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Canadian Institutes of Health Research [Ottawa, Canada] (CIHR), Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [FNS32003B-120760], University of Zurich, Innovations thérapeutiques en hémostase (IThEM - U1140), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Biologie intégrative du tissu osseux, and Jonchère, Laurent

Subjects
diagnosis, [SDV]Life Sciences [q-bio], Infant, Newborn, Female, Humans, Pregnancy, Pulmonary Embolism/epidemiology, Prospective Studies, Angiography/methods, Outcome Assessment, Health Care, Hypothyroidism/epidemiology, Thyrotropin, Guthrie test, hypothyroidism, pregnancy, pulmonary embolism, Angiography, 610 Medicine & health, Hematology, [SDV] Life Sciences [q-bio], Hypothyroidism, 10036 Medical Clinic, Pulmonary Embolism
Abstract

International audience; Background Neonatal hypothyroidism is often raised as a potential concern for the use of computed tomography pulmonary angiography (CTPA) in pregnant women with suspected pulmonary embolism (PE). Objectives To assess the incidence of neonatal hypothyroidism among newborns from mothers exposed to CTPA. Patients/Methods Pregnant women with clinically suspected PE were included in a multicenter, multinational prospective diagnostic management outcome study, based on pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower limb venous compression ultrasonography, and CTPA. Results of Guthrie tests were systematically collected for newborns of all women who required CTPA as part of the diagnostic strategy. A thyroid-stimulating hormone (TSH) level above 15 U/ml was used to define hypothyroidism. Results Out of the 166 women included in the Swiss participating centers, 149 underwent a CTPA including 14 with twin pregnancies. Eight women suffered a pregnancy loss and results of the Guthrie test could not be retrieved for four newborns. All TSH levels were reported as being below 15 U/ml. The incidence of neonatal hypothyroidism was 0/151 (0.0%, 95% confidence interval: 0.0%-2.5%). Conclusions We did not identify any cases of neonatal hypothyroidism in our cohort of 149 pregnant women investigated for suspected PE using a CTPA. Along with previous literature data, this provides further reassuring data regarding the use of CTPA in this indication.

Published
2022

28. Factors associated with COVID-19 vaccine uptake among French population aged 65 years and older: results from a national online survey

Author

Yu-Jin Jung, Amandine Gagneux-Brunon, Marion Bonneton, Elisabeth Botelho-Nevers, Pierre Verger, Jeremy K. Ward, Odile Launay, CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et biothérapies des infections muqueuses (GIMAP), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), and École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
Vaccines, COVID-19 Vaccines, Cross-Sectional Studies, Vaccination, COVID-19, Humans, Geriatrics and Gerontology, Aged, [SHS]Humanities and Social Sciences
Abstract

Background In France, the increase in COVID-19 vaccine uptake among older adults slowed down between May and June 2021. Using the data from a national survey, we aimed to assess COVID-19 vaccine uptake among French residents aged 65 years and older, particularly at risk of severe form of the infection, and identify factors associated with non-vaccination. Methods A cross-sectional online survey collected the immunization status/intention to get the COVID-19 vaccine, reasons for vaccination/non-vaccination and factors potentially associated with vaccine uptake between May 10 and 23, 2021 among a large sample of French residents. Characteristics of participants were compared according to immunization status. Factors potentially associated with non-vaccination were computed into a multivariate logistic regression. Results Among the 1941 survey participants, 1612 (83%) reported having received at least one dose of COVID-19 vaccine. Among the 329 unvaccinated, 197 (60%) declared having the intention to get vaccinated. Younger age (adjusted odds ratio (aOR) = 1.50; 95% confidence interval (CI), 1.05–2.14), thinking previously having COVID-19 (aOR = 4.01; 95% CI, 2.17–7.40), having suffered economic impact due to the pandemic (aOR = 2.63; 95% CI, 1.71–4.04), reporting an “unsafe” opinion about COVID-19 vaccine safety (aOR = 6.79; 95% CI, 4.50–10.26), reporting an “unsupportive” opinion about vaccination in general (aOR = 4.24; 95% CI, 2.77–6.49) were independent risk factors for non-vaccination. On the other hand, trust in COVID-19 vaccine information delivered by the doctor (aOR = 0.28; 95% CI, 0.16–0.48) and trust in the government’s actions (aOR = 0.50; 95% CI, 0.34–0.74) were independent protective factors for non-vaccination. Political affiliation also remained significantly associated with vaccine uptake. Conclusions Despite high overall COVID-19 vaccine uptake among the study participants, differences in vaccine uptake according to the level of concerns regarding COVID-19 vaccine safety, socioeconomic profile and trust in the government were observed. Our results reinforce the importance of “reaching out” vaccination strategy that specifically targets the most vulnerable fringe of older adult population.

Published
2022

29. PET metabolic imaging of time-dependent reorganization of olfactory cued fear memory networks in rats

Author

Anne-Marie Mouly, Philippe Litaudon, Nadine Ravel, Nicolas Costes, Caroline Bouillot, Luc Zimmer, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Hospices Civils de Lyon (HCL), RAVEL, Nadine, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MOULY, Anne-Marie, and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Cognitive Neuroscience, [SDV]Life Sciences [q-bio], Hippocampus, Sensory system, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Piriform cortex, Odor, Animals, Fear conditioning, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Prefrontal cortex, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Memory Consolidation, Cued speech, 0303 health sciences, Recall, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Fear, Cued Fear conditioning, Recent memory, Odor fear conditioning, Rats, [SDV] Life Sciences [q-bio], [18F]FDG micro PET, Positron-Emission Tomography, Mental Recall, Memory consolidation, System-level consolidation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Remote memory, Cues, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract

Memory consolidation involves reorganization at both the synaptic and system levels. The latter involves gradual reorganization of the brain regions that support memory and has been mostly highlighted using hippocampal-dependent tasks. The standard memory consolidation model posits that the hippocampus becomes gradually less important over time in favor of neocortical regions. In contrast, this reorganization of circuits in amygdala-dependent tasks has been less investigated. Moreover, this question has been addressed using primarily lesion or cellular imaging approaches thus precluding the comparison of recent and remote memory networks in the same animals. To overcome this limitation, we used microPET imaging to characterize, in the same animals, the networks activated during the recall of a recent versus remote memory in an olfactory cued fear conditioning paradigm. The data highlighted the drastic difference between the extents of the two networks. Indeed, although the recall of a recent odor fear memory activates a large network of structures spanning from the prefrontal cortex to the cerebellum, significant activations during remote memory retrieval are limited to the piriform cortex. These results strongly support the view that amygdala-dependent memories also undergo system-level reorganization, and that sensory cortical areas might participate in the long-term storage of emotional memories.

Published
2022

30. Immunogenicity and Safety of Beta-Adjuvanted Recombinant Booster Vaccine

Author

Odile Launay, Marine Cachanado, Liem B. Luong Nguyen, Laetitia Ninove, Marie Lachâtre, Inès Ben Ghezala, Marc Bardou, Catherine Schmidt-Mutter, Karine Lacombe, Fabrice Laine, Jean-Sébastien Allain, Elisabeth Botelho-Nevers, Marie-Pierre Tavolacci, Christian Chidiac, Patricia Pavese, Bertrand Dussol, Stéphane Priet, Dominique Deplanque, Amel Touati, Laureen Curci, Eleine Konate, Nadine Ben Hamouda, Anissa Besbes, Eunice Nubret, Florence Capelle, Laurence Berard, Alexandra Rousseau, Eric Tartour, Tabassome Simon, Xavier de Lamballerie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin [AP-HP], Aix Marseille Université (AMU), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Strasbourg, Université Sorbonne Paris Nord, Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Centre d'Investigation Clinique [CHU Rouen] (CIC Rouen), Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civil de Lyon, CHU Grenoble, CHU Marseille, CHU Lille, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Saint-Etienne, and douville, sabine

Subjects
Vaccines, Synthetic, Immunogenicity, Vaccine, Adjuvants, Immunologic, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Immunization, Secondary, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, General Medicine, Antibodies, Viral, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

31. Major gastrointestinal bleeding in patients receiving anticoagulant therapy for venous thromboembolism

Author

Judith Catella, Laurent Bertoletti, Farès Moustafa, José Antonio Nieto, Reina Valle, José María Pedrajas, Aurora Villalobos, Isabelle Quere, Gabrielle Sarlon-Bartoli, Manuel Monreal, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305 (LBTI), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), CHU Clermont-Ferrand, Hospital Virgen De La Luz, Hospital Sierrallana, Partenaires INRAE, Hospital Clínico San Carlos [Madrid, Spain], Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain], Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de la Timone [CHU - APHM] (TIMONE), Germans Trias i Pujol University Hospital [Badalona, Barcelona, Spain] (GTPUH), and Universidad Católica San Antonio de Murcia (UCAM)

Subjects
Male, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Humans, Anticoagulants, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology, Registries, Gastrointestinal Hemorrhage, Pulmonary Embolism, Gastrointestinal bleeding, Aged, Venous thromboembolism
Abstract

International audience; Introduction: The gastrointestinal (GI) tract is a frequent site of bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE). At-risk patients have not been consistently identified yet. Methods: We used the RIETE registry to assess the clinical characteristics of patients developing major GI bleeding during the course of anticoagulation. Then, we built a predictive score based on multivariable analysis, aiming to identify patients at increased risk for major GI bleeding. Results: We included 87,431 patients with acute VTE. During the course of anticoagulation, 778 (0.89%) suffered major GI bleeding, 815 (0.93%) non-major GI bleeding and 1462 (1.67%) had major bleeding outside the GI tract. During the first 30 days after major GI bleeding, 7.6% of patients re-bled, 3.9% had VTE recurrences and 33% died. On multivariable analysis, male sex, age >= 70 years, initial VTE presentation as pulmonary embolism, active cancer, prior VTE, recent major bleeding in the GI tract, esophageal varicosities, anemia, abnormal prothrombin time, renal insufficiency and use of corticosteroids were associated to an increased risk for major GI bleeding. Using the predictive score, 39,591 patients (45%) were at low risk; 36,602 (42%) at intermediate-risk; 9315 (11%) at high-risk; and 1923 (2.2%) at very high risk. Their rates of major GI bleeding were: 0.21%, 0.96%, 2.41% and 6.08%, respectively. The c-statistics was 0.771 (95%CI. 0.755-0.786). Conclusions: We have developed a score which has the potential to identify patients at increased risk for GI bleeding, but needs to be externally validated."

Published
2022

32. Ustekinumab is more effective than azathioprine to prevent endoscopic postoperative recurrence in Crohn's disease

Author

Buisson, Anthony, Nancey, Stéphane, Manlay, Luc, Rubin, David, Hebuterne, Xavier, Pariente, Benjamin, Fumery, Mathurin, Laharie, David, Roblin, Xavier, Bommelaer, Gilles, Pereira, Bruno, Peyrin‐biroulet, Laurent, Vuitton, Lucine, Post-Op Study Grp, Ustek, Service d'Hépatologie Gastro-entérologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service d'Hépatogastroentérologie [CHU Lyon-Sud], Hospices Civils de Lyon (HCL), The University of Chicago Medicine [Chicago], Servcie Hépato-gastroentérolgie et Nutrition clinique [CHU Nice], Centre Hospitalier Universitaire de Nice (CHU Nice), Service Gastro-entérologie adulte – Maladies de l’appareil digestif [CHU Lille], CHU Lille, Service d'Hépato Gastroenterologie [CHU Amiens-Picardie], CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Service Gastroentérologie [CHU Bordeaux], Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Gastro-Entérologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), 'Francois Aupetit' Association (AFA CrohnRCH), CHU Clermont-Ferrand (DRCI), Centre Hospitalier Universitaire de Lille (CHU Lille), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, Service de gastroentérologie [CHU Saint-Etienne], and Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Azathioprine, Antibodies, Monoclonal, Humanized, Gastroenterology, ustekinumab, law.invention, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, Gastrointestinal Agents, Randomized controlled trial, Recurrence, law, Internal medicine, Ustekinumab, Secondary Prevention, medicine, Clinical endpoint, Humans, postoperative recurrence, Propensity Score, Retrospective Studies, Crohn's disease, azathioprine, business.industry, Inflammatory Bowel Disease, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Bowel resection, medicine.disease, Control Groups, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Cohort, Propensity score matching, Original Article, Female, 030211 gastroenterology & hepatology, business, Immunosuppressive Agents, medicine.drug
Abstract

International audience; Background: Preventing postoperative recurrence (POR) is a major concern in Crohn's disease (CD). While azathioprine is an option, no data is available on ustekinumab efficacy in this situation.Aims: We compared the effectiveness of ustekinumab versus azathioprine in preventing endoscopic POR in CD.Methods: We retrospectively collected data from all consecutive CD patients treated with ustekinumab after intestinal resection in 9 centers. The control group (azathioprine alone) was composed of patients who participated in a randomized controlled trial conducted in the same centers comparing azathioprine alone or in combination with curcumin. Propensity score analyses (inversed probability of treatment weighting = IPTW) were applied to compare the two groups. The primary endpoint was endoscopic POR (Rutgeerts' index ≥ i2) at 6 months.Results: Overall, 32 patients were included in the ustekinumab group and 31 in the azathioprine group. The propensity score analysis was adjusted on the main risk factors (smoking, fistulizing phenotype, prior bowel resection, resection length >30 cm and ≥2 biologics before surgery) and thiopurines or ustekinumab exposure prior to surgery making the two arms comparable (∣d∣ < 0.2). After IPTW, the rate of endoscopic POR at 6 months was lower in patients treated with ustekinumab compared to azathioprine (28.0% vs. 54.5%, p = 0.029). After IPTW, the rates of i2b-endoscopic POR (Rutgeerts' index ≥ i2b) and severe endoscopic POR (Rutgeerts' index ≥ i3) were 20.8% versus 42.5% (p = 0.066) and 16.9% versus 27.9% (p = 0.24), in the ustekinumab and azathioprine groups, respectively.Conclusion: Ustekinumab seemed to be more effective than azathioprine in preventing POR in this cohort of CD patients.

Published
2021

33. Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges

Author

Adrian Newman-Tancredi, Luc Zimmer, Oriane Razakarivony, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Neurolixis, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Rayet, Béatrice, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
Agonist, medicine.drug_class, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Neuroimaging, medicine, Radioligand, Receptor, Antipsychotic, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Biological Psychiatry, business.industry, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Schizophrenia, Serotonin, business, Neuroscience, 030217 neurology & neurosurgery, Preclinical imaging, Biomarkers
Abstract

The serotonin 5-HT1A receptor has attracted wide attention as a target for treatment of psychiatric disorders. Although this receptor is important in the pharmacological mechanisms of action of new-generation antipsychotics, its characterization remains incomplete. Studies based on in vitro molecular imaging on brain tissue by autoradiography, and more recently in vivo PET imaging, have not yielded clear results, in particular due to the limitations of current 5-HT1A radiotracers, which lack specificity and/or bind to all 5-HT1A receptors, regardless of their functional status. The new concept of PET neuroimaging of functionally active G-protein-coupled receptors makes it possible to revisit PET brain exploration by enabling new research paradigms. For the 5-HT1A receptor it is now possible to use [18F]-F13640, a 5-HT1A receptor radioligand with high efficacy agonist properties, to specifically visualize and quantify functionally active receptors, and to relate this information to subjects’ pathophysiological or pharmacological state. We therefore propose imaging protocols to follow changes in the pattern of functional 5-HT1A receptors in relation to mood deficits or cognitive processes. This could allow improved discrimination of different schizophrenia phenotypes and greater understanding of the basis of therapeutic responses to antipsychotic drugs. Finally, as well as targeting functionally active receptors to gain insights into the role of 5-HT1A receptors, the concept can also be extended to the study of other receptors involved in the pathophysiology or therapy of psychiatric disorders.

Published
2021

34. Automated Coding in Case Mix Databases of Bacterial Infections Based on Antimicrobial Susceptibility Test Results

Author

Radia Spiga, François-Elie Calvier, Anne Carricajo, Bruno Pozzetto, Béatrice Trombert-Paviot, Cédric Bousquet, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, Commission Spécialisée Maladies infectieuses et maladies émergentes (CSMime), Haut Conseil de la Santé Publique (HCSP), Service de santé publique et d'information médicale [CHU Saint-Etienne] (SSPIM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Breuil, Florent, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Institut Henri Fayol, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), and Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS)

Subjects
Bacteria, Clinical Coding, Electronic Health Records, Health care payment system, France, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract

International audience; Our objective was to improve the accuracy of bacteria and resistance coding in a hospital case mix database. Data sources consisted of 50,074 files on bacteriological susceptibility tests transmitted with the HPRIM protocol from laboratory management system to electronic health record of the University hospital of Saint Etienne in July 2017. An algorithm was implemented to detect susceptibility tests containing information corresponding to codes whose addition in the case mix database was susceptible to increase the severity level of a diagnosis related group. Among 132 hospital stays fulfilling the conditions, 27 were lacking bacteria and/or resistance codes, and the tariff was increased for 9 stays, with earnings of €54,612. Analyzing Antimicrobial susceptibility tests helps to improve clinical coding and optimize the financial gain.

Published
2022

35. Prevalence of anti-TNF contraindications in Crohn’s disease: A cross-sectional survey from the GETAID

Author

Aurelien Amiot, Philippe Seksik, Jean-Marie Reimund, Maria Nachury, Romain Altwegg, Arnaud Bourreille, Stephanie Viennot, Mathurin Fumery, Xavier Roblin, Melanie Serrero, Matthieu Allez, Claire Painchart, Elise Chanteloup, Lucine Vuitton, Ginette Fotsing, Anthony Buisson, Baya Coulibaly, Stephane Nancey, Cyrielle Gilletta, Laurianne Plastaras, Vered Abitbol, Lucas Guillo, Marion Simon, Stephane Nahon, David Laharie, Laurent Peyrin-Biroulet, Guillaume Bouguen, Charlotte Gagniere, Pauline Wils, Yoram Bouhnik, Carmen Stefanescu, Xavier Treton, Carole Martins, Mathieu Uzzan, Emilie Del Tedesco, Laurent Beaugerie, Anne Bourrier, Cecilia Landmann, Julien Kirchgesner, Harry Sokol, Gilles Boschetti, Claire Gay, Pauline Danion, Bernard Flourié, Georgia Malamut, Benedicte Caron, Camille Zallot, Jean-Marc Gornet, Clotilde Baudry, Caroline Trang-Poisson, Medina Boualit, Lucile Boivineau, Pauline Riviere, Florian Poullenot, Benoit Coffin, Henri Duboc, Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375) (EC2M3), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Voies de Signalisation du Développement et du Stress Cellulaire dans les Cancers Digestifs et Urologiques, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University Hospital of Montpellier, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Groupe d’Étude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Aix Marseille Université (AMU), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier [Valenciennes, Nord], Hôpital Saint-Joseph [Marseille], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre hospitalier universitaire de Poitiers (CHU Poitiers), CHU Clermont-Ferrand, Centre Hospitalier Henri Duffaut (Avignon), Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CH Colmar, Hôpital Cochin [AP-HP], Institut Mutualiste de Montsouris (IMM), Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, CHU Bordeaux [Bordeaux], Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], This study was supported by an institutional grant by Takeda, CRHU Nancy, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Saint-Etienne, and CHU Toulouse [Toulouse]

Subjects
Crohn’s disease, Hepatology, Contraindications, [SDV]Life Sciences [q-bio], Gastroenterology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Inflammatory bowel disease, Anti-TNF, Cross-Sectional Studies, Treatment Outcome, Crohn Disease, Prevalence, Humans, Tumor Necrosis Factor Inhibitors, Ustekinumab, Contraindication
Abstract

International audience; BACKGROUND: The exact rate of contraindications to anti-TNF therapy and physician perspectives on treatment choices facing to anti-TNF contraindication, are poorly reported. METHODS: A two-week cross-sectional study was conducted in 31 centres. Physicians completed a questionnaire for a total of 1,314 consecutive outpatients with Crohn’s disease, assessing each patient’s potential contraindications to anti-TNF therapy, the choice of alternative therapy to anti-TNFs, and their preference in an unrestricted reimbursement setting. RESULTS: Among the 1,293 responses to the first item, 148 (11.5%) reported 32 absolute contraindications (2.5%) and 116 relative contraindications (9.0%) to anti-TNF therapy. When asked about their preference of alternative therapies in those cases with contraindications to anti-TNF, physicians chose ustekinumab and vedolizumab, 75.6% and 23.9%, respectively. In multivariable analysis, the choice of vedolizumab was the preferred choice for patients aged > 60 years with the L2 phenotype and the absence of perianal lesions. In a hypothetical setting of unrestricted reimbursement, anti-TNFs remained physicians’ preferred first-line biological therapy choice for 78.2%. CONCLUSION: Anti-TNF contraindications occurred in up to 11.5% of patients with Crohn’s disease. Physicians’ choices for alternative therapy to anti-TNF relied on ustekinumab in 75.6% and vedolizumab in 23.9% of these cases. This choice was driven mainly by phenotypical criteria and age.

Published
2022

36. Elucidating the role of the gut microbiota in the physiological effects of dietary fiber

Author

Edward C. Deehan, Zhengxiao Zhang, Alessandra Riva, Anissa M. Armet, Maria Elisa Perez-Muñoz, Nguyen K. Nguyen, Jacqueline A. Krysa, Benjamin Seethaler, Yuan-Yuan Zhao, Janis Cole, Fuyong Li, Bela Hausmann, Andreas Spittler, Julie-Anne Nazare, Nathalie M. Delzenne, Jonathan M. Curtis, Wendy V. Wismer, Spencer D. Proctor, Jeffrey A. Bakal, Stephan C. Bischoff, Dan Knights, Catherine J. Field, David Berry, Carla M. Prado, Jens Walter, University of Alberta, Jimei University [Fujian, China] (JMU), University of Vienna [Vienna], University of Hohenheim, Medizinische Universität Wien = Medical University of Vienna, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French-Clinical Research Infrastructure Network / F-CRIN [Lyon] (Cardiovascular & Renal Clinical Trialists - INI-CRCT ), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Minnesota [Twin Cities] (UMN), University of Minnesota System, University College Cork (UCC), National University of Ireland [Galway] (NUI Galway), CarMeN, laboratoire, and UCL - SSS/LDRI - Louvain Drug Research Institute

Subjects
Inflammation, Adult, Dietary Fiber, Male, Microbiology (medical), Bacteria, [SDV]Life Sciences [q-bio], Insulin resistance, Gut microbiota, Microbiology, Satiety, Gastrointestinal Microbiome, [SDV] Life Sciences [q-bio], Bile Acids and Salts, Feces, Adults, Humans, Female, Obesity, Leukocyte L1 Antigen Complex, Biomarkers
Abstract

BackgroundDietary fiber is an integral part of a healthy diet, but questions remain about the mechanisms that underlie effects and the causal contributions of the gut microbiota. Here, we performed a 6-week exploratory trial in adults with excess weight (BMI: 25–35 kg/m2) to compare the effects of a high-dose (females: 25 g/day; males: 35 g/day) supplement of fermentable corn bran arabinoxylan (AX;n= 15) with that of microbiota-non-accessible microcrystalline cellulose (MCC;n= 16). Obesity-related surrogate endpoints and biomarkers of host-microbiome interactions implicated in the pathophysiology of obesity (trimethylamineN-oxide, gut hormones, cytokines, and measures of intestinal barrier integrity) were assessed. We then determined whether clinical outcomes could be predicted by fecal microbiota features or mechanistic biomarkers.ResultsAX enhanced satiety after a meal and decreased homeostatic model assessment of insulin resistance (HOMA-IR), while MCC reduced tumor necrosis factor-α and fecal calprotectin. Machine learning models determined that effects on satiety could be predicted by fecal bacterial taxa that utilized AX, as identified by bioorthogonal non-canonical amino acid tagging. Reductions in HOMA-IR and calprotectin were associated with shifts in fecal bile acids, but correlations were negative, suggesting that the benefits of fiber may not be mediated by their effects on bile acid pools. Biomarkers of host-microbiome interactions often linked to bacterial metabolites derived from fiber fermentation (short-chain fatty acids) were not affected by AX supplementation when compared to non-accessible MCC.ConclusionThis study demonstrates the efficacy of purified dietary fibers when used as supplements and suggests that satietogenic effects of AX may be linked to bacterial taxa that ferment the fiber or utilize breakdown products. Other effects are likely microbiome independent. The findings provide a basis for fiber-type specific therapeutic applications and their personalization.Trial registrationClinicaltrials.gov,NCT02322112, registered on July 3, 2015.

Published
2022

37. Impact of the COVID-19 pandemic on disease stage and treatment for patients with pancreatic adenocarcinoma: A French comprehensive multicentre ambispective observational cohort study (CAPANCOVID)

Author

Mathias Brugel, Léa Letrillart, Camille Evrard, Aurore Thierry, David Tougeron, Mehdi El Amrani, Guillaume Piessen, Stéphanie Truant, Anthony Turpin, Christelle d'Engremont, Gaël Roth, Vincent Hautefeuille, Jean M. Regimbeau, Nicolas Williet, Lilian Schwarz, Frédéric Di Fiore, Christophe Borg, Alexandre Doussot, Aurélien Lambert, Valérie Moulin, Hélène Trelohan, Marion Bolliet, Amalia Topolscki, Ahmet Ayav, Anthony Lopez, Damien Botsen, Tulio Piardi, Claire Carlier, Olivier Bouché, Centre Hospitalier Universitaire de Reims (CHU Reims), Université de Reims Champagne-Ardenne (URCA), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes (UGA), CHU Amiens-Picardie, Chirurgie digestive [CHU Amiens], Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service de chirurgie digestive [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Etablissement Français du Sang de Bourgogne Franche-Comté (site de Dijon) (EFS BFC (site de Dijon)), Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Groupe hospitalier de La Rochelle, CH Colmar, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Lorraine (UL), Institut Jean Godinot [Reims], Vieillissement, Fragilité (VIEFRA - EA 3797), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Universitaire de Reims [CHU Reims], Institut des Mondes Africains [IMAF], Centre hospitalier universitaire de Poitiers [CHU Poitiers], Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP], Hôpital Claude Huriez [Lille], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], Cooperator Multidisciplinary Oncology Group [GERCOR], Service de Gastro-Entérologie [CHRU Besançon], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB], Simplification des soins chez les patients complexes - UR UPJV 7518 [SSPC], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] [CHU ST-E], Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen [CLCC Henri Becquerel], CHU Dijon, and Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] [UNICANCER/ICL]

Subjects
Cancer Research, Care pathway, Pancreatic neoplasms, Pandemic, SARS-CoV-2, COVID-19, Adenocarcinoma, Cohort Studies, Oncology, Communicable Disease Control, Humans, Pandemics, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cancer
Abstract

International audience; Background: The COVID-19 pandemic caused major oncology care pathway disruption. The CAPANCOVID study aimed to evaluate the impact on pancreatic adenocarcinoma (PA) - from diagnosis to treatment - of the reorganisation of the health care system during the first lockdown.Methods: This multicentre ambispective observational study included 833 patients diagnosed with PA between September 1, 2019 and October 31, 2020 from 13 French centres. Data were compared over three periods defined as before the outbreak of COVID-19, during the first lockdown (March 1 to May 11, 2020) and after lockdown.Results: During the lockdown, mean weekly number of new cases decreased compared with that of pre-pandemic levels (13.2 vs. 10.8, -18.2%; p = 0.63) without rebound in the post-lockdown period (13.2 vs. 12.9, -1.7%; p = 0.97). The number of borderline tumours increased (13.6%-21.7%), whereas the rate of metastatic diseases rate dropped (47.1%-40.3%) (p = 0.046). Time-to-diagnosis and -treatment were not different over periods. Waiting neoadjuvant chemotherapy in resectable tumours was significantly favoured (24.7%-32.6%) compared with upfront surgery (13%-7.8%) (p = 0.013). The use of mFOLFIRINOX preoperative chemotherapy regimen decreased (84.9%-69%; p = 0.044). After lockdown, the number of borderline tumours decreased (21.7%-9.6%) and advanced diseases increased (59.7%-69.8%) (p = 0.046). SARS-CoV-2 infected 39 patients (4.7%) causing 5 deaths (12.8%).Conclusion: This cohort study suggests the existence of missing diagnoses and of a shift in disease stage at diagnosis from resectable to advanced diseases with related therapeutic modifications whose prognostic consequences will be known after the planned follow-up.Trial registration: Clinicaltrials.gov NCT04406571.

Published
2022

38. Kappa Free Light Chain Biomarkers Are Efficient for the Diagnosis of Multiple Sclerosis: A Large Multicenter Cohort Study

Author

Michael Levraut, Sabine Laurent-Chabalier, Xavier Ayrignac, Kévin Bigaut, Manon Rival, Sanae Squalli, Hélène Zéphir, Tifanie Alberto, Jean-David Pekar, Jonathan Ciron, Damien Biotti, Bénédicte Puissant-Lubrano, Jean-Philippe Camdessanché, Yannick Tholance, Olivier Casez, Bertrand Toussaint, Jeanne Marion, Thibault Moreau, Daniela Lakomy, Audrey Thomasset, Elisabeth Maillart, Delphine Sterlin, Aude Maurousset, Auriane Rocher, David Axel Laplaud, Edith Bigot-Corbel, Pierre-Olivier Bertho, Jean Pelletier, Joseph Boucraut, Pierre Labauge, Thierry Vincent, Jérôme De Sèze, Isabelle Jahn, Barbara Seitz-Polski, Eric Thouvenot, Christine Lebrun-Frenay, Université Côte d'Azur - Faculté de Médecine (UCA Faculté Médecine), Université Côte d'Azur (UCA), Unité de Recherche Clinique de la Côte d’Azur (URRIS UR2CA), Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Les Hôpitaux Universitaires de Strasbourg (HUS), Thèses d'exercice et mémoires - UFR de Médecine Montpellier-Nîmes, Université de Montpellier (UM), Laboratoire de Biochimie [CHRU Nîmes], Département de neurologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Pôle Neurosciences [CHU Toulouse], Institut Fédératif de Biologie (IFB), Service de Neurologie [CHU de Saint-Étienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Universitaire [Grenoble] (CHU), Translational microbial Evolution and Engineering (TIMC-TrEE), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Pathologie cellulaire : aspects moléculaires et viraux / Pathologie et Virologie Moléculaire, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service de Biochimie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Team 5 : Neuroinflammation, mechanisms, therapeutic options (NEMO) (U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Laboratoire de Biochimie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Département de Biochimie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Nord Laennec [CHU Nantes], Hôpital de la Timone [CHU - APHM] (TIMONE), Aix Marseille Université (AMU), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], CHU Strasbourg, Laboratoire Immunologie [Nice], Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Hôpital de l'Archet-Université Côte d'Azur (UCA), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Service de Neurologie [CHU Nice], Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), Société Francophone de la Sclérose En Plaques (SFSEP)., and Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
MESH: Humans, MESH: Multiple Sclerosis, Multiple Sclerosis, MESH: Demyelinating Diseases* / diagnosis, [SDV]Life Sciences [q-bio], Oligoclonal Bands, MESH: Immunoglobulin kappa-Chains, MESH: Central Nervous System Diseases, MESH: Oligoclonal Bands, Cohort Studies, Immunoglobulin kappa-Chains, Neurology, Central Nervous System Diseases, MESH: Biomarkers, Humans, Female, Neurology (clinical), MESH: Cohort Studies, MESH: Female, Biomarkers, Demyelinating Diseases
Abstract

Background and ObjectivesKappa free light chains (KFLC) seem to efficiently diagnose MS. However, extensive cohort studies are lacking to establish consensus cut-offs, notably to rule out non-MS autoimmune CNS disorders. Our objectives were to (1) determine diagnostic performances of CSF KFLC, KFLC index, and KFLC intrathecal fraction (IF) threshold values that allow us to separate MS from different CNS disorder control populations and compare them with oligoclonal bands' (OCB) performances and (2) to identify independent factors associated with KFLC quantification in MS.MethodsWe conducted a retrospective multicenter study involving 13 French MS centers. Patients were included if they had a noninfectious and nontumoral CNS disorder, eligible data concerning CSF and serum KFLC, albumin, and OCB. Patients were classified into 4 groups according to their diagnosis: MS, clinically isolated syndrome (CIS), other inflammatory CNS disorders (OIND), and noninflammatory CNS disorder controls (NINDC).ResultsOne thousand six hundred twenty-one patients were analyzed (675 MS, 90 CIS, 297 OIND, and 559 NINDC). KFLC index and KFLC IF had similar performances in diagnosing MS from nonselected controls and OIND (p= 0.123 andp= 0.991 for area under the curve [AUC] comparisons) and performed better than CSF KFLC (p< 0.001 for all AUC comparisons). A KFLC index of 8.92 best separated MS/CIS from the entire nonselected control population, with better performances than OCB (p< 0.001 for AUC comparison). A KFLC index of 11.56 best separated MS from OIND, with similar performances than OCB (p= 0.065). In the multivariate analysis model, female gender (p= 0.003), young age (p= 0.013), and evidence of disease activity (p< 0.001) were independent factors associated with high KFLC index values in patients with MS, whereas MS phenotype, immune-modifying treatment use at sampling, and the FLC analyzer type did not influence KFLC index.DiscussionKFLC biomarkers are efficient tools to separate patients with MS from controls, even when compared with other patients with CNS autoimmune disorder. Given these results, we suggest using KFLC index or KFLC IF as a criterion to diagnose MS.Classification of EvidenceThis study provides Class III evidence that KFLC index or IF can be used to differentiate patients with MS from nonselected controls and from patients with other autoimmune CNS disorders.

Published
2022

39. Impact of a school-based and primary care-based multicomponent intervention on HPV vaccination coverage among French adolescents: a cluster randomised controlled trial protocol (the PrevHPV study)

Author

Bocquier, Aurélie, Michel, Morgane, Giraudeau, Bruno, Bonnay, Stéphanie, Gagneux-Brunon, Amandine, Gauchet, Aurélie, Gilberg, Serge, Le Duc-Banaszuk, Anne-Sophie, Mueller, Judith E., Chevreul, Karine, Thilly, Nathalie, Raude, Jocelyn, Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Hôpital Robert Debré, MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR des Sciences Pharmaceutiques et Biologiques (Nantes Univ - UFR Pharmacie), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre d’Investigation Clinique [Tours] CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie et biothérapies des infections muqueuses (GIMAP), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Centre d'Investigation Clinique - Epidémiologie Clinique Saint-Etienne (CIC-EC), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social (LIP-PC2S), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Grenoble Alpes (UGA), Université Paris Cité (UPCité), Centre régional de coordination des dépistages des cancers-Pays de la Loire, Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Université Paris Cité (UPCité)-Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodologie Promotion Investigation [CHRU Nancy] (MPI), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Département des sciences humaines et sociales (SHS), The study is conducted with the support of IReSP and with financial support from ITMO Cancer AVIESAN (Alliance Nationale pour les Sciences de la Vie et de la Santé/ National Alliance for Life Sciences & Health) within the framework of the Cancer Plan 2014–2019, and PrevHPV Study group: Nelly Agrinier, Estelle Fall, Céline Pulcini, Sébastien Bruel, Marie Ecollan, Dragos-Paul Hagiu, Josselin Le Bel, Henri Partouche, Juliette Pinot, Louise Rossignol, Arthur Tron, Minghui Zuo, Gaëlle Vareilles, Julie Bros, Catherine Juneau, Marion Branchereau, Elisabeth Botelho-Nevers, Géraldine Jambon, Florian Jeanleboeuf, Julie Kalecinski, Christine Lasset, Laetitia Marie DitAsse, Jonathan Sicsic, Jocelyn Raude, Sandra Chyderiotis, Damien Oudin-Doglioni, Anne-Sophie Barret, Isabelle Bonmarin, Daniel Levy-Bruhl, Clémence Castagnet, Mélanie Simony

Subjects
Public health, Schools, Vaccination Coverage, Adolescent, Primary Health Care, Papillomavirus Infections, Vaccination, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Papillomavirus Vaccines, Medical education & training, Randomized Controlled Trials as Topic
Abstract

IntroductionVaccination is an effective and safe strategy to prevent Human papillomavirus (HPV) infection and related harms. Despite various efforts by French authorities to improve HPV vaccine coverage (VC) these past few years, VC has remained far lower than in most other high-income countries. To improve it, we have coconstructed with stakeholders a school-based and primary care-based multicomponent intervention, and plan to evaluate its effectiveness, efficiency and implementation through a cluster randomised controlled trial (cRCT).Methods and analysisThis pragmatic cRCT uses an incomplete factorial design to evaluate three components applied alone or in combination: (1) adolescents and parents’ education and motivation at school, using eHealth tools and participatory learning; (2) general practitioners’ training on HPV using motivational interviewing techniques and provision of a decision aid tool; (3) free-of-charge access to vaccination at school. Eligible municipalities (clusters) are located in one of 14 preselected French school districts and must have only one secondary school which enrols at least 2/3 of inhabitants aged 11–14 years. A randomisation stratified by school district and deprivation index allocated 90 municipalities into 6 groups of 15. The expected overall sample size estimate is 41 940 adolescents aged 11–14 years. The primary endpoint is the HPV VC (≥1 dose) among adolescents aged 11–14 years, at 2 months, at the municipality level (data from routine databases). Secondary endpoints include: HPV VC (≥1 dose at 6 and 12 months; and 2 doses at 2, 6 and 12 months); differences in knowledge, attitudes, behaviours, and intention among adolescents, parents and general practitioners between baseline and 2 months after intervention (self-administered questionnaires); incremental cost-effectiveness ratio. Implementation measures include dose, fidelity, adaptations, reached population and satisfaction (activity reports and self-administered questionnaires).Ethics and disseminationThis protocol was approved by the French Ethics Committee ‘CPP Sud-Est VI’ on 22 December 2020 (ID-RCB: 2020-A02031-38). No individual consent was required for this type of research; all participants were informed of their rights, in particular not to participate or to oppose the collection of data concerning them. Findings will be widely disseminated (conference presentations, reports, factsheets and academic publications).Trial registration numberNCT04945655.

Published
2022

40. Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk

Author

Harimalala Ranaivo, Florence Thirion, Christel Béra-Maillet, Susie Guilly, Chantal Simon, Monique Sothier, Laurie Van Den Berghe, Nathalie Feugier-Favier, Stéphanie Lambert-Porcheron, Isabelle Dussous, Loïc Roger, Hugo Roume, Nathalie Galleron, Nicolas Pons, Emmanuelle Le Chatelier, Stanislav Dusko Ehrlich, Martine Laville, Joël Doré, Julie-Anne Nazare, CarMeN, laboratoire, Démonstrateurs - MetaGenoPolis - - MGP2011 - ANR-11-DPBS-0001 - DPBS - VALID, Intensity mapping of the atomic carbon CII line - CONCERTO - - Intensity mapping of the atomic carbon CII line: the promise of a new observational probe of dusty star-formation in post-reionization and reionization epoch2017-01-01 - 0000-00-00 - PE9, ERC-2017-ADG - VALID, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French-Clinical Research Infrastructure Network / F-CRIN [Lyon] (Cardiovascular & Renal Clinical Trialists - INI-CRCT ), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bridor - Groupe LE DUFF [Rennes] (BGLD), This study was funded by Bridor and in part by Metagenopolis grant Agence Nationale de la Recherche ANR-11-DPBS-0001. JD acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement ERC-2017-AdG No. 788191 - Homo.symbiosus). We thank all the subjects who participated in this study. We thank Bernard Henrissat who annotated the IGC2 with CAZy., ANR-11-DPBS-0001,MGP,MetaGenoPolis(2011), European Project: PE9, ERC-2017-ADG, Intensity mapping of the atomic carbon CII line: the promise of a new observational probe of dusty star-formation in post-reionization and reionization epoch,Advanced Grant (AdG), PE9, ERC-2017-ADG,CONCERTO(2017), FCRIN/FORCE Network, Centre d'Edition Numérique Scientifique (CENS), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-CHU Grenoble-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)

Subjects
Microbiology (medical), Dietary Fiber, gut microbiota, [SDV]Life Sciences [q-bio], Gastroenterology, Dietary fiber diversity, Bread, Microbiology, Gastrointestinal Microbiome, [SDV] Life Sciences [q-bio], Infectious Diseases, Eisenbergiella sp, Cardiovascular Diseases, Parabacteroides distasonis, Metabolome, glycoside hydrolases, Humans, cardiometabolic profile
Abstract

International audience; Some cardiometabolic risk factors such as dyslipidemia and insulin resistance are known to be associated with low gut microbiota richness. A link between gut microbiota richness and the diversity of consumed dietary fibers (DF) has also been reported. We introduced a larger diversity of consumed DF by using a daily consumed bread in subjects at cardiometabolic risk and assessed the impacts on the composition and functions of gut microbiota as well as on cardiometabolic profile. Thirty-nine subjects at cardiometabolic risk were included in a double-blind, randomized, cross-over, twice 8-week study, and consumed daily 150 g of standard bread or enriched with a 7-dietary fiber mixture (5.55 g and 16.05 g of fibers, respectively). Before and after intervention, stool samples were collected for gut microbiota analysis from species determination down to gene-level abundance using shotgun metagenomics, and cardiometabolic profile was assessed. Multi-fiber bread consumption significantly decreased Bacteroides vulgatus, whereas it increased Parabacteroides distasonis, Fusicatenibacter saccharivorans, an unclassified Acutalibacteraceae and an unclassified Eisenbergiella (q \textless 0.1). The fraction of gut microbiota carrying the gene coding for five families/subfamilies of glycoside hydrolases (CAZymes) were also increased and negatively correlated with peaks and total/incremental area under curve (tAUC/iAUC) of postprandial glycemia and insulinemia. Compared to control bread, multi-fiber bread decreased total cholesterol (-0.42 mM; q \textless 0.01), LDL cholesterol (-0.36 mM; q \textless 0.01), insulin (-2.77 mIU/l; q \textless 0.05), and HOMA (-0.78; q \textless 0.05). In conclusion, increasing the diversity of DF in a daily consumed product modifies gut microbiota composition and function and could be a relevant nutritional tool to improve cardiometabolic profile.

Published
2022

41. Cardiac radioablation for ventricular tachycardia: Which approach for incorporating cardiorespiratory motions into the planning target volume?

Author

Julien, Bellec, Louis, Rigal, Aurélien, Hervouin, Raphaël, Martins, Mathieu, Lederlin, Nicolas, Jaksic, Joël, Castelli, Karim, Benali, Renaud, de Crevoisier, Antoine, Simon, CRLCC Eugène Marquis (CRLCC), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), the French Federation of Cardiology (FFC)., Jonchère, Laurent, and CHU Saint-Etienne

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, Cardiac radioablation, Lung Neoplasms, Radiotherapy Planning, Computer-Assisted, Respiration, ITV, Biophysics, General Physics and Astronomy, Ventricular tachycardia, General Medicine, Motion, 4D CT, Tachycardia, Ventricular, cardiovascular system, Humans, Radiology, Nuclear Medicine and imaging, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Four-Dimensional Computed Tomography, Motion management
Abstract

International audience; PURPOSE: To evaluate different approaches for generating a cardiorespiratory ITV for cardiac radioablation. METHODS: Four patients with ventricular tachycardia were included in this study. For each patient, cardiac-gated and respiration-correlated 4D-CT scans were acquired. The cardiorespiratory ITV was defined using registrations of the cardiac and respiratory 4D-CT images. Five different approaches, which differed in the number of incorporated cardiac phases (1, 2, 10, or 1 with a fixed 3 mm margin (FM) expansion) and respiratory phases (2 or 10), were evaluated. For each approach, a VMAT treatment plan was simulated. Target coverage (TC) and spill were evaluated geometrically and dosimetrically for each approach. RESULTS: When employing one cardiac phase, the TC did not exceed 85%. Using the two extreme phases of the cardiac and respiratory cycles resulted in a geometric TC 89%, dosimetric TC > 92%) was only achieved when combining 10 respiratory phases with either 2 or 10 cardiac phases or a single cardiac phase with FM. The use of a single cardiac phase with FM combined with 10 respiratory phases lead to a mean geometric and dosimetric spill of 43% and 35%, respectively. CONCLUSION: For cardiac radioablation, the use of two extreme cardiac phases combined with 10 respiratory phases is a robust approach to generate a cardiorespiratory ITV. The use of a single cardiac phase with or without fixed margin expansion is not recommended based on this study.

Published
2022

42. Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness

Author

Magnus Bäck, Constance Xhaard, Raphael Rouget, Quentin Thuillier, Oscar Plunde, Susanna C. Larsson, Nicolas Girerd, João Pedro Ferreira, Jean-Marc Boivin, Erwan Bozec, Ludovic Mercklé, Faiez Zannad, Axelle Hoge, Michèle Guillaume, Claire Dandine-Roulland, Edith Le Floch, Delphine Bacq-Daian, Jean-François Deleuze, Laurie Van den Berghe, Julie-Anne Nazare, Martine Laville, Christiane Branlant, Isabelle Behm-Ansmant, Sandra Wagner, Patrick Rossignol, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Uppsala University, Université de Liège, Centre National de Recherche en Génomique Humaine (CNRGH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hospices Civils de Lyon (HCL), BEHM-ANSMANT, Isabelle, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)

Subjects
Inflammation, Kardiologi, Prevention, STANISLAS cohort, Dietary, Omega-3 fatty acids, Cardiac and Cardiovascular Systems, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Arterial stiffness
Abstract

Aims Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality and cardiovascular events. The aim of the present study was to determine the association of PUFA intake, FADS1 genotype, and FADS expression with arterial stiffness. Methods and results A cross-sectional population-based cohort study of 1464 participants without overt cardiovascular disease was conducted. Dietary intake was assessed using a food frequency questionnaire. Arterial stiffness was assessed by carotid–femoral pulse wave velocity (cfPWV), and the FADS1 locus variant was determined. Blood cell transcriptomics was performed in a subset of 410 individuals. Pulse wave velocity was significantly associated with the FADS1 locus variant. Differential associations between PWV and omega-3 PUFA intake were observed depending on the FADS1 genotype. High omega-3 PUFA intake attenuated the FADS1 genotype-dependent associations. Carriers of the minor FADS1 locus variant exhibited increased expression of FADS2, which is associated with PWV. Conclusion Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention.

Published
2022

43. Public opinion on a mandatory COVID-19 vaccination policy in France: a cross-sectional survey

Author

Pierre Verger, Amandine Gagneux-Brunon, Patrick Peretti-Watel, Jeremy K. Ward, Marion Bonneton, Odile Launay, Elisabeth Botelho-Nevers, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Université Jean Monnet - Saint-Étienne (UJM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), CHU Saint-Etienne, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), COMBE, Isabelle, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), and ANR-20-COV8-0009,SLAVACO,Suivi Longitudinal des Attitudes à l'égard d'un VAccin contre la COVID-19.(2020)

Subjects
Adult, Microbiology (medical), COVID-19 Vaccines, Multivariate analysis, Adolescent, Cross-sectional study, Population, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Humans, Medicine, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, education, Reference group, Aged, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, education.field_of_study, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, SARS-CoV-2, business.industry, Vaccination, COVID-19, General Medicine, Odds ratio, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Confidence interval, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cross-Sectional Studies, Policy, Infectious Diseases, Vaccination policy, Public Opinion, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, France, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Demography
Abstract

Objectives Reaching the last pockets of unvaccinated people is challenging, and has led to consider COVID-19 mandatory vaccination. Our aim was to assess attitudes toward COVID-19 mandatory vaccination in France before the announcement and factors associated with opposition to this type of policy. Methods Between the 10th and the 23rd of May 2021, we conducted a cross-sectional online survey among a representative sample of the French population aged 18 and over and a specific sample of the French Senior Population over 65. Results Among 3,056 respondents, 1,314 (43.0 %) were in favor of mandatory COVID-19 vaccination, 1,281 (41.9 %) were opposed to such a policy, and 461 (15.1 %) were undecided. Among opponents to COVID-19 mandatory vaccination for the general population, 385 (30.05 %) were in favor of a mandatory COVID-19 vaccination for healthcare workers (HCWs). In multivariate analysis, age groups 18-24 years, and 25-34 years were significantly more opposed than the reference group (>75 years old) with respective adjusted odds ratio (aOR) and 95 % confidence interval (95 % CI) 4.67 (1.73-12.61) and 3.74 (1.57-8.93). No intention of getting COVID-19 vaccine was strongly associated with opposition to mandatory vaccination with aOR 10.67 (95 % CI 6.41-17.76). In comparison with partisans of the center, partisans of the far left and green parties were more likely to be opposed to COVID-19 mandatory vaccine with respective aOR (95 % CI) 1;89 (1.06-3.38) and 2.08 (1.14-3.81). Conclusion Attitudes toward mandatory COVID-19 vaccination are split in the French general population, and the debate might become politicized.

Published
2022

44. Resistance to lean mass gain in constitutional thinness in free‐living conditions is not overpassed by overfeeding

Author

James Minnion, Christophe Montaurier, François-Pierre Martin, Jacques Epelbaum, Joyceline Cuenco, Jörg Hager, Dominique Grouselle, Sylvie Mure, Yves Boirie, Jérôme Carayol, Sofia Moco, Bogdan Galusca, Bruno Estour, Yiin Ling, Thierry Thomas, Nele Gheldof, Natacha Germain, Simona Bartova, CHU Saint-Etienne, University Hospital and University Jean Monnet, Metabolic Health, Nestlé Research, EPFL Innovation Park, Lausanne, INSERM UMR894-Centre de Psychiatrie et Neurosciences (CPN), Universite´ Paris Descartes, Sorbonne Paris Cite, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Imperial College London, Nestle Research, Switzerland, ROSSI, Sabine, and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Nitrogen balance, lcsh:Diseases of the musculoskeletal system, Adolescent, Anabolism, Constitutional Thinness, Urine, Weight Gain, Bodyweight gain, lcsh:QM1-695, Excretion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Thinness, Physiology (medical), Internal medicine, medicine, Humans, Orthopedics and Sports Medicine, Overfeeding, 2. Zero hunger, business.industry, Original Articles, lcsh:Human anatomy, Energy gap, 3. Good health, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, Endocrinology, Social Conditions, 030220 oncology & carcinogenesis, Body Composition, Anorectic, Lean body mass, Original Article, Female, lcsh:RC925-935, Underweight, medicine.symptom, Energy Metabolism, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Weight gain
Abstract

International audience; BackgroundConstitutional thinness (CT), a non‐malnourished underweight state with no eating disorders, is characterized by weight gain resistance to high fat diet. Data issued from muscle biopsies suggested blunted anabolic mechanisms in free‐living state. Weight and metabolic responses to protein caloric supplementation has not been yet explored in CT.MethodsA 2 week overfeeding (additional 600 kcal, 30 g protein, 72 g carbohydrate, and 21 g fat) was performed to compare two groups of CTs (12 women and 11 men) to normal‐weight controls (12 women and 10 men). Bodyweight, food intake, energy expenditure, body composition, nitrogen balance, appetite hormones profiles, and urine metabolome were monitored before and after overfeeding.ResultsBefore overfeeding, positive energy gap was found in both CT genders (309 ± 370 kcal in CT‐F and 332 ± 709 kcal in CT‐M) associated with higher relative protein intake per kilo (1.74 ± 0.32 g/kg/day in CT‐F vs. 1.16 ± 0.23 in C‐F, P < 0.0001; 1.56 ± 0.36 in CT‐M vs. 1.22 ± 0.32 in C‐M, P = 0.03), lower nitrogen (7.26 ± 2.36 g/day in CT‐F vs. 11.41 ± 3.64 in C‐F, P = 0.003; 9.70 ± 3.85 in CT‐M vs. 14.14 ± 4.19 in C‐M, P = 0.02), but higher essential amino acids urinary excretion (CT/C fold change of 1.13 for leucine and 1.14 for arginine) in free‐living conditions. After overfeeding, CTs presented an accentuated positive energy gap, still higher than in controls (675 ± 540 in CTs vs. 379 ± 427 in C, P = 0.04). Increase in lean mass was induced in both controls genders but not in CTs (a trend was noticed in CT women), despite a similar nitrogen balance after overfeeding (5.06 ± 4.33 g/day in CTs vs. 4.28 ± 3.15 in controls, P = 0.49). Higher anorectic gut hormones' tone, glucagon‐like peptide 1 and peptide tyrosine tyrosine, during test meal and higher snacking frequency were noticed before and after overfeeding in CTs.ConclusionsThe blunted muscle energy mechanism, previously described in CTs in free‐living state, is associated with basal saturated protein turn over suggested by the concordance of positive nitrogen balance and an increased urine excretion of several essential amino acids. This saturation cannot be overpassed by increasing this spontaneous high‐protein intake suggesting a resistance to lean mass gain in CT phenotype.

Published
2020

45. Electrophysiological features of chronic inflammatory demyelinating polyradiculoneuropathy associated with IgG4 antibodies targeting neurofascin 155 or contactin 1 glycoproteins

Author

Kouton, Ludivine, Boucraut, José, Devaux, Jérome, Rajabally, Yusuf, Adams, David, Antoine, Jean Christophe, Bourdain, Frédéric, Brodovitch, Alexandre, Camdessanché, Jean-Philippe, Cauquil, Cécile, Ciron, Jonathan, Dubard, Thierry, Echaniz-Laguna, Andoni, Grapperon, Aude-Marie, Juntas-Morales, Raul, Kremer, Laurent, Kuntzer, Thierry, Labeyrie, Céline, Lanfranco, Luca, Léger, Jean-Marc, Maisonobe, Thierry, Mavroudakis, Nicolas, Mecharles-Darrigol, Sylvie, Merle, Philippe, Noury, Jean-Baptiste, Rouaud, Violaine, Tard, Céline, Théaudin, Marie, Vallat, Jean-Michel, Viala, Karine, Attarian, Shahram, Delmont, Emilien, Ludivine, Kouton, José, Boucraut, Jérome, Devaux, Yusuf, Rajabally, David, Adams, Christophe, Antoine, Frédéric, Bourdain, Alexandre, Brodovitch, Jean-Philippe, Camdessanché, Cécile, Cauquil, Jonathan, Ciron, Thierry, Dubard, Andoni, Echaniz-Laguna, Aude-Marie, Grapperon, Raul, Juntas-Morales, Laurent, Kremer, Thierry, Kuntzer, Céline, Labeyrie, Luca, Lanfranco, Jean-Marc, Léger, Thierry, Maisonobe, Nicolas, Mavroudakis, Sylvie, Mecharles-Darrigol, Philippe, Merle, Jean- Baptiste, Noury, Violaine, Rouaud, Céline, Tard, Marie, Théaudin, Jean-Michel, Vallat, Karine, Viala, Shahram, Attarian, Emilien, Delmont, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Laboratoire d'Immunologie [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University Hospitals Birmingham [Birmingham, Royaume-Uni], Hôpital Foch [Suresnes], Adhésion et Inflammation (LAI), Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie, CHU Saint-Etienne, Institut des Neurosciences de Montpellier (INM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)

Subjects
Male, Pathology, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Neural Conduction, Nerve conduction velocity, 0302 clinical medicine, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Node of Ranvier, biology, 05 social sciences, Middle Aged, Sensory Systems, 3. Good health, medicine.anatomical_structure, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Neurology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Antibody, Contactin 1, medicine.medical_specialty, 050105 experimental psychology, 03 medical and health sciences, Physiology (medical), medicine, Humans, 0501 psychology and cognitive sciences, Nerve Growth Factors, Aged, Autoantibodies, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Polyradiculoneuropathy, medicine.disease, Median nerve, Median Nerve, Electrophysiology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, chemistry, Immunoglobulin G, biology.protein, Neurology (clinical), Glycoprotein, business, Cell Adhesion Molecules, 030217 neurology & neurosurgery
Abstract

Objective Chronic inflammatory demyelinating polyradiculoneuropathies (CIDP) with antibodies against neurofascin 155 (Nfasc155) or contactin-1 (CNTN1) have distinctive clinical features. Knowledge on their electrophysiological characteristics is still scarce. In this study, we are investigating whether these patients have specific electrophysiological characteristics. Methods The electrophysiological data from 13 patients with anti-Nfasc155 IgG4 antibodies, 9 with anti-CNTN1 IgG4 antibodies were compared with those of 40 consecutive CIDP patients without antibodies. Results All the patients with antibodies against Nfasc155 or CNTN1 fulfilled the EFNS/PNS electrodiagnostic criteria for definite CIDP. There was no electrophysiological difference between patients with anti-CNTN1 and anti-Nfasc155 antibodies. Nerve conduction abnormalities were heterogeneously distributed along nerves trunks and roots. They were more pronounced than in CIDP without antibodies. Motor conduction velocity on median nerve 7.4 ms were predictive of positive antibodies against the node of Ranvier with a sensitivity of 59% and a specificity of 93%. Conclusions Marked conduction abnormalities may suggest the presence of positive antibodies against the node of Ranvier. Significance Anti-Nfasc155 and anti-CNTN1 antibodies target the the paranodal axo-glial domain but are associated with nerve conduction abnormalities mimicking a “demyelinating” neuropathy.

Published
2020

46. Comparative efficacy and safety of vedolizumab and infliximab in ulcerative colitis after failure of a first subcutaneous anti-TNF agent: a multicentre cohort study

Author

Pauline Rivière, Jérôme Filippi, Mathurin Fumery, Xavier Roblin, Arnaud Bourreille, Laurent Peyrin-Biroulet, Felix Goutorbe, Marianne Hupé, David Laharie, Mireille Simon, Guillaume Bouguen, Stéphane Nancey, Romain Altwegg, L Caillo, CHU Pessac, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Service de gastroentérologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nice (CHU Nice), Service d'Hépato Gastroenterologie [CHU Amiens-Picardie], CHU Amiens-Picardie, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Adult, Male, Comparative Effectiveness Research, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Injections, Subcutaneous, Antibodies, Monoclonal, Humanized, Gastroenterology, Vedolizumab, Cohort Studies, Biological Factors, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Internal medicine, medicine, Adalimumab, Humans, Pharmacology (medical), Retrospective Studies, Hepatology, Drug Substitution, Tumor Necrosis Factor-alpha, business.industry, Antibodies, Monoclonal, Retrospective cohort study, Odds ratio, Middle Aged, medicine.disease, Ulcerative colitis, Infliximab, Golimumab, 3. Good health, Discontinuation, Treatment Outcome, 030220 oncology & carcinogenesis, Colitis, Ulcerative, Female, 030211 gastroenterology & hepatology, business, medicine.drug
Abstract

International audience; Background - Few data exist to help select a second biologic agent in patients with refractory ulcerative colitis (UC). Aim - To compare the efficacy of infliximab (IFX) and vedolizumab (VDZ) in UC patients who failed a first subcutaneous anti-tumor necrosing factor (TNF) agent. Methods - Consecutive UC patients from 12 French centres starting IFX or VDZ after at least one injection of adalimumab or golimumab have been included in a retrospective study. Outcomes were clinical remission at week 14, survival without treatment discontinuation and survival without UC-related event. Results - Among the 225 patients included, clinical remission at week 14 was achieved in 40/154 (26%) patients treated with IFX and in 35/71 (49%) treated with VDZ (P = 0.001). After a propensity score matching analysis, this difference remained significant (odds ratio: 1.67; 95% confidence interval: 1.08-2.56; P = 0.02). With a median follow-up of 117 weeks, survival rates without treatment discontinuation at years 1 and 3 were 50% and 29% with IFX, and 80% and 55% with VDZ, respectively (P

Published
2020

47. Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency

Author

Ashley N. Sigafoos, Salima El Chehadeh, Marcia C. Willing, Ela Akay, Florian Cherik, Anne-Marie E. Goyette, Vinodh Narayanan, Diane Masser-Frye, Catherine Karimov, Rhonda E. Schnur, Rebekah Bressi, Rhys H. Thomas, Gary D. Clark, Tina Barbaro-Dieber, Jill A. Rosenfeld, Carlos A. Bacino, Maria J. Guillen Sacoto, Laura Russell, Kristin Lindstrom, Caroline Schluth-Bolard, Xia Wang, Yvonne Hilhorst-Hofstee, Marcelo Vargas, Zehua Zhu, Ash Zawerton, Boris Keren, Mariëtte J.V. Hoffer, Isabelle Marey, Alice Poisson, Daphné Lehalle, Maries Joseph, Gaetan Lesca, Simon Zwolinski, Laurence Perrin, Rhoda Akilapa, Emilia K. Bijlsma, Christel Depienne, Amélie Piton, Claire G. Salter, Lucie Dupuis, Daryl A. Scott, Jolien S. Klein Wassink-Ruiter, Benjamin Cogné, Mathilde Nizon, Richard Chang, Kirsty McWalter, Myriam Srour, Perrine Charles, Anne-Claude Tabet, Natalie Canham, Sylvie Odent, Caroline Nava, Karl J. Clark, Elizabeth J. Bhoj, Jonathan Levy, Keri Ramsey, Yves Alembik, Lucia Ortega, Sophie Dupuis-Girod, Shoji Ichikawa, Christine Francannet, Marta Bertoli, Christèle Dubourg, Eric W. Klee, Ange-Line Bruel, Sebastien Moutton, Emily Fassi, Anthony Vandersteen, Abdul Haseeb, Antonina Wojcik, Patrick R. Blackburn, Lynne M. Bird, Patrick Rump, Véronique Lefebvre, Alma Kuechler, Sophie Nambot, Keren Machol, Cyril Mignot, Andreas Hartmann, Rossana Sanchez Russo, Erica H. Gerkes, Sylvie Jaillard, Roberto Mendoza-Londono, Trevor Cole, Pauline Monin, Cleveland Clinic, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Département de génétique [Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Center for Human and Clinical Genetics, Leiden University Medical Center (LUMC), Service de génétique médicale - Unité de génétique clinique [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Health Sciences Research [Mayo Clinic] (HSR), Mayo Clinic, This research was funded in part by the Agence Nationale de la Recherche and European High-Functioning Autism Network (ANR EUHFAUTISM), the Assistance Publique–Hôpitaux de Paris (AP-HP), the Institut National de la Santé et de la Recherche Médicale (INSERM), the BioPsy labex (to Christel Depienne and C.N.) and the Association Française du Syndrome Gilles de la Tourette (AFSGT) to Christel Depienne. It was also funded by the Cleveland Clinic Lerner Research Institute (LRI Chair’s Innovative Research Award to V.L.), and by Harper’s Quest and the LAMSHF Syndrome Research Fund (donations to V.L.) and the Center for Individualized Medicine, Mayo Clinic. This study makes use of data generated by the DECIPHER community and the Deciphering Developmental Disorders (DDD) Study, which is funded by the Wellcome Trust. The DDD study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between Wellcome and the Department of Health, and the Wellcome Sanger Institute (grant number WT098051). The views expressed in this publication are those of the author(s) and not necessarily those of Wellcome or the Department of Health. The study has UK Research Ethics Committee approval (10/H0305/83, granted by the Cambridge South REC, and GEN/284/12 granted by the Republic of Ireland REC). The research team acknowledges the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network., We thank the patients and their families for their participation in this study, and the C4RCD Research Group (Newell Belnap, Amanda Courtright, Ana Claasen, David Craig, Matt Huentelman, Madison LaFleur, Sampathkumar Rangasamy, Ryan Richholt, Isabelle Schrauwen, Ashley L. Siniard, and Szabolics Szelinger) for providing clinical information on patient P18., Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Génétique et Cytogénétique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital universitaire Robert-Debré [Paris], Centre d'Exploration et de Recherche Médicales par Émission de Positons (CERMEP), Université Joseph Fourier - Grenoble 1 (UJF)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, Medizin, Haploinsufficiency, L-SOX5, VARIANTS, 0302 clinical medicine, Neurodevelopmental disorder, Intellectual disability, Missense mutation, 2.1 Biological and endogenous factors, Aetiology, Child, Genetics (clinical), Genetics, Pediatric, Genetics & Heredity, 0303 health sciences, Pedigree, FAMILY, DNA-Binding Proteins, developmental delay, TRANSCRIPTION FACTORS, Phenotype, intellectual disability, Child, Preschool, missense variants, Female, SOXD Transcription Factors, Adult, EXPRESSION, Adolescent, Intellectual and Developmental Disabilities (IDD), Clinical Sciences, Mutation, Missense, autism, Cell fate determination, Biology, LONG FORM, SEQUENCE, Article, 03 medical and health sciences, Young Adult, Rare Diseases, Clinical Research, CARTILAGE, Intellectual Disability, medicine, Animals, Humans, Language Development Disorders, Genetic Predisposition to Disease, Preschool, Transcription factor, Gene, 030304 developmental biology, [SDV.GEN]Life Sciences [q-bio]/Genetics, MUTATIONS, Human Genome, Infant, medicine.disease, Brain Disorders, Neurodevelopmental Disorders, Deciphering Developmental Disorder Study, Mutation, Autism, epilepsy, Missense, 030217 neurology & neurosurgery, GENERATION
Abstract

International audience; PURPOSE: Lamb-Shaffer syndrome (LAMSHF) is a neurodevelopmental disorder described in just over two dozen patients with heterozygous genetic alterations involving SOX5, a gene encoding a transcription factor regulating cell fate and differentiation in neurogenesis and other discrete developmental processes. The genetic alterations described so far are mainly microdeletions. The present study was aimed at increasing our understanding of LAMSHF, its clinical and genetic spectrum, and the pathophysiological mechanisms involved.METHODS: Clinical and genetic data were collected through GeneMatcher and clinical or genetic networks for 41 novel patients harboring various types of SOX5 alterations. Functional consequences of selected substitutions were investigated.RESULTS: Microdeletions and truncating variants occurred throughout SOX5. In contrast, most missense variants clustered in the pivotal SOX-specific high-mobility-group domain. The latter variants prevented SOX5 from binding DNA and promoting transactivation in vitro, whereas missense variants located outside the high-mobility-group domain did not. Clinical manifestations and severity varied among patients. No clear genotype-phenotype correlations were found, except that missense variants outside the high-mobility-group domain were generally better tolerated.CONCLUSIONS:This study extends the clinical and genetic spectrum associated with LAMSHF and consolidates evidence that SOX5 haploinsufficiency leads to variable degrees of intellectual disability, language delay, and other clinical features.

Published
2020

48. OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions

Author

António L. Palmeira, Thorkild I. A. Sørensen, Martin Neovius, Martine Laville, Mikael Rydén, Andrea Natali, Maud Alligier, Romain Barrès, Kristina Campbell, David Jacobi, I. Sadaf Farooqi, Jean-Michel Oppert, Helen M. Roche, André Scheen, Karine Clément, Ellen E. Blaak, Yves Boirie, Gijs H. Goossens, Jason C.G. Halford, Luc Tappy, Nathalie Farpour-Lambert, Hannele Yki-Järvinen, Uberto Pagotto, Chantal Simon, Jörg Hager, Jildau Bouwman, Paul Brunault, Gema Frühbeck, Dominique Langin, Olivier Ziegler, Chantal Julia, Hans Hauner, Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), University of Copenhagen = Københavns Universitet (KU), Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], CHU Clermont-Ferrand, Netherlands Organization for Applied Scientific Research (TNO), TNO Science and Industry, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), KC Microbiome Communications Group, Nutrition et obésités: approches systémiques (nutriomics) (UMR-S 1269 INSERM - Sorbonne Université), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, University of Cambridge [UK] (CAM), Université de Genève (UNIGE), Geneva University Hospitals and Geneva University, Clínica Universidad de Navarra [Pamplona], Nestlé Institute of Health Sciences SA [Lausanne, Switzerland], University of Liverpool, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Klinikums rechts der Isar, Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pisa - Università di Pisa, Karolinska Institutet [Stockholm], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Alma Mater Studiorum University of Bologna (UNIBO), Université de Lisbonne, University College Dublin [Dublin] (UCD), Centre Hospitalier Universitaire de Liège (CHU-Liège), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Lausanne (UNIL), Minerva Foundation Institute for Medical Research, University of Helsinki, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Joint Programming Initiative Heathy Diet for Healthy Life, Alligier M., Barres R., Blaak E.E., Boirie Y., Bouwman J., Brunault P., Campbell K., Clement K., Farooqi I.S., Farpour-Lambert N.J., Fruhbeck G., Goossens G.H., Hager J., Halford J.C.G., Hauner H., Jacobi D., Julia C., Langin D., Natali A., Neovius M., Oppert J.M., Pagotto U., Palmeira A.L., Roche H., Ryden M., Scheen A.J., Simon C., Sorensen T.I.A., Tappy L., Yki-Jarvinen H., Ziegler O., Laville M., FCRIN/FORCE Network, Centre de Recherche en Nutrition Humaine Rhône-Alpes, Novo Nordisk, Department of Human Biology, Maastricht University Medical Center (MUMC), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, TNO,Netherlands Organisation for Applied Scientific Research, UMR U 1253, Université de Tours, Nutrition et obésité : approches systémiques, Sorbonne Université, Wellcome-MRC Institute of Metabolic Science and NIHR Biomedical Research Centre, University of Cambridge, Service of Therapeutic Education for Chronic Diseases, Department of Community Health, Primary Care and Emergency, Geneva University Hospitals, Department of Endocrinology and Nutrition, Navarra Public Health Institute, Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición - Biomedical Research Center in Red-Physiopathology of Obesity and Nutrition (CIBEROBN), University of Navarra, University of Cape Town, Metabolic Phenotyping, Nestlé Institute of Health Sciences, Psychological Sciences, University of Liverpool (University of Liverpool), Institut für Ernährungsmedizin des Klinikums Rechts der Isar, Technical University of Munich (TUM), Institut du Thorax, Centre Hospitalier Universitaire de Nantes, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université Toulouse III - Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Department of Medicine (Solna), Nutrition, Institut de Cardiométabolisme et Nutrition (ICAN), CHU Pitié-Salpêtrière [APHP], Department of Medical and Surgical Sciences, Universita degli Studi di Padova, CIPER, PANO-SR, Faculty of Human Kinetics, University of Lisbon, UCD Institute of Food and Health, University College Dublin (UCD), Department of Medicine, The University of Sydney, Diabètes, Nutrition et maladies métaboliques, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Physiologie, Université de Picardie Jules Verne (UPJV), Helsinki University Central Hospital, Endocrinologie, Diabetes et Nutrition, Hôpital Brabois, Maastricht University [Maastricht]-Maastricht University [Maastricht], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, ProdInra, Archive Ouverte, Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), University of Copenhagen = Københavns Universitet (UCPH), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Université de Genève = University of Geneva (UNIGE), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lausanne = University of Lausanne (UNIL), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, HUS Internal Medicine and Rehabilitation, Humane Biologie, and RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health

Subjects
0301 basic medicine, Research design, Gerontology, Health (social science), Psychological intervention, Choice Behavior, 0302 clinical medicine, QUALITY-OF-LIFE, OBSTRUCTIVE SLEEP-APNEA, Medicine, Medical History Taking, lcsh:RC620-627, Interventions, METABOLIC SYNDROME, Randomized Controlled Trials as Topic, ddc:616, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Precision medicine, Prognosis, C-REACTIVE PROTEIN, 3. Good health, Europe, lcsh:Nutritional diseases. Deficiency diseases, CARDIOVASCULAR-DISEASE, Research Design, Variable, lcsh:Nutrition. Foods and food supply, Human, Prognosi, education, WEIGHT-LOSS, lcsh:TX341-641, Intervention, 030209 endocrinology & metabolism, GASTRIC BYPASS-SURGERY, Guidelines, Patient care, 03 medical and health sciences, Variables, Physiology (medical), Humans, CORONARY-HEART-DISEASE, Obesity, Expert Testimony, Core set, 030109 nutrition & dietetics, business.industry, Stratification, medicine.disease, Diet, BODY-MASS INDEX, Clinical trial, PHYSICAL-ACTIVITY, Biological Variation, Population, 3121 General medicine, internal medicine and other clinical medicine, Metabolic syndrome, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing - focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals' responses to an intervention for obesity - ultimately leading to better patient care and improved obesity outcomes. © 2020 The Author(s) Published by S. Karger AG, Basel.

Published
2020

49. Diuretic vs. placebo in intermediate-risk acute pulmonary embolism: a randomized clinical trial

Author

Roger Rosario, Jacques Mansourati, Clément Delmas, Gwénolé Rohel, Pierre-André Natella, Sylvie Bastuji-Garin, Muriel Paul, Pascal Lim, Jean-Luc Dubois-Randé, Anne Bernard, Olivier Lairez, Bernard Tardy, Olivier Sanchez, Caroline Biendel, Nicolas Meneveau, Romain Gallet, Tabassome Simon, Pierre Coste, Hélène Bouvaist, Gilles Chatelier, Mustapha Sebbane, Fabrice Ivanes, Damien Fard, Richard Layese, Francis Couturaud, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), F-Crin Innovte [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Department of Cardiology, University Hospital Jean Minjoz, Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Departement de Cardiologie [Hôpital Saint-Joseph - Marseille], Aix Marseille Université (AMU)-Hôpital Saint-Joseph [Marseille], CHU Grenoble, Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Université de Brest (UBO), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), CHU Bordeaux [Bordeaux], Université de Bordeaux (UB), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Université de Tours (UT), CHU Henri Mondor [Créteil], Hôpital Henri Mondor, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Clinical Research Unit (URC Mondor), Hôpitaux Universitaires Henri-Mondor AP-HP, IMRB - CEPIA/'Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cardiology, Hôpital Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], CHU Toulouse [Toulouse], and CHU Henri Mondor

Subjects
Randomization, medicine.medical_treatment, Ventricular Dysfunction, Right, [SDV]Life Sciences [q-bio], Critical Care and Intensive Care Medicine, Placebo, law.invention, Randomized controlled trial, Double-Blind Method, law, Furosemide, medicine, Humans, Diuretics, business.industry, General Medicine, medicine.disease, Pulmonary embolism, Blood pressure, Treatment Outcome, Anesthesia, Acute Disease, Diuretic, Bolus (digestion), Cardiology and Cardiovascular Medicine, business, Pulmonary Embolism, medicine.drug
Abstract

Aims The role of diuretics in patients with intermediate-risk pulmonary embolism (PE) is controversial. In this multicentre, double-blind trial, we randomly assigned normotensive patients with intermediate-risk PE to receive either a single 80 mg bolus of furosemide or a placebo. Methods and results Eligible patients had at least a simplified PE Severity Index (sPESI) ≥1 with right ventricular dysfunction. The primary efficacy endpoint assessed 24 h after randomization included (i) absence of oligo-anuria and (ii) normalization of all sPESI items. Safety outcomes were worsening renal function and major adverse outcomes at 48 hours defined by death, cardiac arrest, mechanical ventilation, or need of catecholamine. A total of 276 patients underwent randomization; 135 were assigned to receive the diuretic, and 141 to receive the placebo. The primary outcome occurred in 68/132 patients (51.5%) in the diuretic and in 49/132 (37.1%) in the placebo group (relative risk = 1.30, 95% confidence interval 1.04–1.61; P = 0.021). Major adverse outcome at 48 h occurred in 1 (0.8%) patients in the diuretic group and 4 patients (2.9%) in the placebo group (P = 0.19). Increase in serum creatinine level was greater in diuretic than placebo group [+4 µM/L (−2; 14) vs. −1 µM/L (−11; 6), P Conclusion In normotensive patients with intermediate-risk PE, a single bolus of furosemide improved the primary efficacy outcome at 24 h and maintained stable renal function. In the furosemide group, urine output increased, without a demonstrable improvement in heart rate, systolic blood pressure, or arterial oxygenation. ClinicalTrials.gov identifier NCT02268903.

Published
2022

50. Quality of Beverage Intake and Cardiometabolic and Kidney Outcomes: Insights From the STANISLAS Cohort

Author

Sandra Wagner, Thomas Merkling, Nicolas Girerd, Erwan Bozec, Laurie Van den Berghe, Axelle Hoge, Michèle Guillaume, Mehmet Kanbay, Céline Cakir-Kiefer, Simon N. Thornton, Jean-Marc Boivin, Ludovic Mercklé, Martine Laville, Patrick Rossignol, Julie-Anne Nazare, Kanbay, Mehmet (ORCID 0000-0002-1297-0675 & YÖK ID 110580), Wagner, S., Merkling, T., Girerd, N., Bozec, E., Van den Berghe, L., Hoge, A., Guillaume, M., Cakir Kiefer, C., Thornton, S.N., Boivin, J.M., Merckle, L., Laville, M., Rossignol, P., Nazare J.A., School of Medicine, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Liège, Koç University, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The fourth examination of the STANISLAS study was sponsored by the Centre Hospitalier Régional Universitaire of Nancy (CHRU) and supported by the French Ministry of Health (Programme Hospitalier de Recherche Clinique Inter-régional 2013), the Contrat de Plan Etat-Lorraine IT2MP and the Fonds Européen de Développement Régional (FEDER Lorraine), a public grant overseen by the French National Research Agency (ANR) as part of the second Investissements d'Avenir program FIGHT-HF (reference: ANR-15-RHU-0004), and the French Projet investissement d'avenir (PIA) project Lorraine Université d'Excellence (reference ANR-15-IDEX-04-LUE). The STANISLAS study is also supported by the sixth European Union—Framework Program (EU-FP) Network of Excellence Ingenious HyperCare (#LSHM-CT-2006–037093), the seventh EU-FP MEDIA (Européen Cooperation—Theme Health/FP7-HEALTH-2010-single-stage #261409), HOMAGE (Heart Omics in Aging, 7th Framework Program grant #305507), FOCUS-MR (reference: ANR-15-CE14-0032-01), and FIBRO-TARGETS (FP7#602904) projects, and by ERA-CVD EXPERT (reference: ANR-16-ECVD-0002-02)., ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), ANR-15-CE14-0032,MR-focus,Régulation, Diagnostique et Thérapeutique ciblée du récepteur minéralocorticoïde dans le remodelage cardiaque(2015), ANR-16-ECVD-0002,EXPERT,Exploring new pathways in age-related heart diseases(2016), European Project: #LSHM-CT-2006–037093, European Project: 602904,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,FIBRO-TARGETS(2013), European Project: 261409,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,MEDIA(2011), European Project: 305507, BOZEC, Erwan, Combattre l'insuffisance cardiaque - - FIGHT-HF2015 - ANR-15-RHUS-0004 - RHUS - VALID, ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID, Régulation, Diagnostique et Thérapeutique ciblée du récepteur minéralocorticoïde dans le remodelage cardiaque - - MR-focus2015 - ANR-15-CE14-0032 - AAPG2015 - VALID, Exploring new pathways in age-related heart diseases - - EXPERT2016 - ANR-16-ECVD-0002 - ERA-CVD - VALID, sixth European union – framework program (EU-FP) Network of Excellence Ingenious HyperCare (#LSHM-CT-2006–037093) - #LSHM-CT-2006–037093 - INCOMING, Targeting cardiac fibrosis for heart failure treatment - FIBRO-TARGETS - - EC:FP7:HEALTH2013-09-01 - 2017-08-31 - 602904 - VALID, The MEtabolic Road to DIAstolic Heart Failure - MEDIA - - EC:FP7:HEALTH2011-01-01 - 2016-06-30 - 261409 - VALID, HOMAGE (Heart Omics in Ageing consortium) - 305507 - INCOMING, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)

Subjects
2. Zero hunger, metabolic health, beverages, Nutrition and Dietetics, Nutrition. Foods and food supply, Endocrinology, Diabetes and Metabolism, Healthy Beverage Index, adult consumption, cardiovascular health, 030204 cardiovascular system & hematology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Nutrition and dietetics, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, parasitic diseases, TX341-641, 030212 general & internal medicine, kidney function, Nutrition, Original Research, Adult consumption, Beverages, Cardiovascular health, Healthy beverage index, Kidney function, Metabolic health, Food Science
Abstract

Background and aims: beverages are an important aspect of diet, and their quality can possibly affect health. The Healthy Beverage Index (HBI) has been developed to take into account these effects. This study aimed to highlight the relationships between health and beverage quality by assessing the association of the HBI and its components with kidney and cardiometabolic (CM) outcomes in an initially healthy population-based familial cohort. Methods: this study included 1,271 participants from the STANISLAS cohort. The HBI, which includes 10 components of habitual beverage consumption, was calculated. Associations of the HBI and its components with estimated glomerular filtration rate (eGFR), albuminuria, hypertriglyceridemic waist (HTG waist), metabolic syndrome (MetS), carotid-femoral pulse wave velocity (cfPWV), carotid intima-media thickness (cIMT), and left ventricular mass (LV mass) were analyzed using multivariable linear or logistic regression models. Results: the median HBI score was 89.7 (78.6–95) out of 100 points. While the overall HBI score was not significantly associated with any of the studied outcomes, individual HBI components were found differently associated with the outcomes. cfPWV and cIMT were lower in participants who did not meet the full-fat milk criteria (p = 0.03 and 0.001, respectively). In men, higher cfPWV was observed for the “low Fat milk” (p = 0.06) and “alcohol” (p = 0.03) non-adherence criteria. Odds of HTG waist were higher with the non-adherence to sugar-sweetened beverages criteria (p < 0.001). eGFR was marginally higher with non-adherence to the coffee/tea criteria (p = 0.047). Conclusions: In this initially healthy population, HBI components were differently associated with kidney and cardiometabolic outcomes, despite a good overall HBI score. Our results highlight specific impacts of different beverage types and suggest that beverages could have an impact on kidney and cardiometabolic health., Centre Hospitalier Regional Universitaire of Nancy (CHRU); French Ministry of Health (Programme Hospitalier de Recherche Clinique Inter-regional 2013); Fonds Europeen de Developpement Regional (FEDER Lorraine); French National Research Agency (ANR); European Union (EU); Horizon 2020; 6th EU Research Framework Programme Network of Excellence Ingenious HyperCare; 7th Research Framework Programme Europeen Cooperation-Theme Health/FP7HEALTH-2010-single-stage; Heart OMics in AGEing (HOMEGA); FOCUS-MR; FIBROTARGETS; ERA-CVD EXPERT; Contrat de Plan Etat-Lorraine IT2MP

Published
2022
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